gentamicin has been researched along with Interstitial Nephritis in 24 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report a case of a 51-year-old male who was treated with vancomycin and gentamicin for primary osteomyelitis with methicillin resistant Staphyloccocus aureus bacteremia." | 7.76 | Biopsy proven interstitial nephritis following treatment with vancomycin: a case report. ( Ehsan, M; Graeber, C; Matthews, M; Posadas, A; Salazar, MN, 2010) |
| "These data show that inhibition of NF-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin." | 7.72 | Inhibition of nuclear factor-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin. ( Coimbra, TM; Costa, RS; da Silva, CG; Volpini, RA, 2004) |
| "Two patients developed acute interstitial nephritis (AIN) following treatment with mezlocillin sodium." | 7.67 | Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection. ( Bauman, J; Copley, JB; Cushner, HM; Hill, SC, 1985) |
| " We report a case of a 51-year-old male who was treated with vancomycin and gentamicin for primary osteomyelitis with methicillin resistant Staphyloccocus aureus bacteremia." | 3.76 | Biopsy proven interstitial nephritis following treatment with vancomycin: a case report. ( Ehsan, M; Graeber, C; Matthews, M; Posadas, A; Salazar, MN, 2010) |
| " We report a case of acute interstitial nephritis induced by immunoallergic drug mechanisms, in a 3-week-old infant who presented with acute renal failure associated with eosinophilia and hepatitis and who had received cefotaxime and gentamicin." | 3.76 | [A neonatal case of immunoallergic acute interstitial nephritis]. ( Allani-Essid, N; Bataille, J; Essid, A; Estournet, B; Rubinsztajn, R, 2010) |
| "These data show that inhibition of NF-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin." | 3.72 | Inhibition of nuclear factor-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin. ( Coimbra, TM; Costa, RS; da Silva, CG; Volpini, RA, 2004) |
| "Two patients developed acute interstitial nephritis (AIN) following treatment with mezlocillin sodium." | 3.67 | Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection. ( Bauman, J; Copley, JB; Cushner, HM; Hill, SC, 1985) |
| "Interstitial nephritis with acute renal failure was observed in 5 cases out of 6 treated by the association of methicillin and gentamycin, wheras no case, was observed when each of these antibodies was used separately." | 3.65 | [The nephrotoxicity of the methicillin-gentamycin combination. Apropos of 5 cases]. ( Becq-Giraudon, B; Pourrat, O; Sudre, Y; Yver, L, 1976) |
| "Gentamicin is an aminoglycoside antibiotic that induces severe nephrotoxicity and acute renal failure." | 1.35 | Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury. ( Bledsoe, G; Chao, J; Chao, L; Grass, D; Hagiwara, M; Mizell, B; Shen, B; Teuton, M; Yao, YY, 2008) |
| "Gentamicin-treated rats presented a transitory increase in plasma creatinine levels." | 1.33 | Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. ( Balbi, AP; Coimbra, TM; Costa, RS; Volpini, RA, 2006) |
| "Kidney histology of the tissue from GM-treated rats showed necrosis and desquamation of tubular epithelial cells in renal cortex as well as interstitial nephritis." | 1.31 | Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. ( Al-Majed, AA; Al-Rikabi, AC; Al-Shabanah, OA; Mostafa, AM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (66.67) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salazar, MN | 1 |
| Matthews, M | 1 |
| Posadas, A | 1 |
| Ehsan, M | 1 |
| Graeber, C | 1 |
| Essid, A | 1 |
| Allani-Essid, N | 1 |
| Rubinsztajn, R | 1 |
| Estournet, B | 1 |
| Bataille, J | 1 |
| Al-Majed, AA | 1 |
| Mostafa, AM | 1 |
| Al-Rikabi, AC | 1 |
| Al-Shabanah, OA | 1 |
| Volpini, RA | 2 |
| Costa, RS | 2 |
| da Silva, CG | 1 |
| Coimbra, TM | 2 |
| Rangan, GK | 1 |
| Wang, Y | 1 |
| Tay, YC | 1 |
| Coombes, JD | 1 |
| Harris, DC | 1 |
| Balbi, AP | 1 |
| Bledsoe, G | 1 |
| Shen, B | 1 |
| Yao, YY | 1 |
| Hagiwara, M | 1 |
| Mizell, B | 1 |
| Teuton, M | 1 |
| Grass, D | 1 |
| Chao, L | 1 |
| Chao, J | 1 |
| Pusey, CD | 3 |
| Saltissi, D | 3 |
| Bloodworth, L | 1 |
| Rainford, DJ | 3 |
| Christie, JL | 1 |
| Kourilsky, O | 1 |
| Solez, K | 1 |
| Morel-Maroger, L | 1 |
| Whelton, A | 1 |
| Duhoux, P | 1 |
| Sraer, JD | 1 |
| Cronin, RE | 1 |
| Bulger, RE | 1 |
| Southern, P | 1 |
| Henrich, WL | 1 |
| Bell, GM | 1 |
| Thomson, D | 1 |
| Thomsen, HS | 1 |
| Dorph, S | 1 |
| Larsen, S | 1 |
| Horn, T | 1 |
| Hemmingsen, L | 1 |
| Skaarup, P | 1 |
| Golman, K | 1 |
| Svendsen, O | 1 |
| Yver, L | 1 |
| Becq-Giraudon, B | 1 |
| Pourrat, O | 1 |
| Sudre, Y | 1 |
| Flynn, CT | 1 |
| Sweet, R | 1 |
| Houghton, DC | 1 |
| English, J | 1 |
| Bennett, WM | 1 |
| Chakŭrski, I | 1 |
| Minkova, V | 1 |
| Belovezhdov, N | 1 |
| Cushner, HM | 1 |
| Copley, JB | 1 |
| Bauman, J | 1 |
| Hill, SC | 1 |
| Fillastre, JP | 1 |
| Woodroffe, AJ | 1 |
| Thomson, NM | 1 |
| Meadows, R | 1 |
| Lawrence, JR | 1 |
| Plafker, J | 1 |
| Mioli, V | 1 |
| Albertazzi, A | 1 |
| Scolari, P | 1 |
| Bortolotti, GC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Randomized, Placebo-Controlled, First-in-Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Administered DF-003 Following Single (Part 1) and Multiple (Part 2) Ascending Doses in Healthy Subjects[NCT05997641] | Phase 1 | 96 participants (Anticipated) | Interventional | 2023-09-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for gentamicin and Interstitial Nephritis
| Article | Year |
|---|---|
Biopsy proven interstitial nephritis following treatment with vancomycin: a case report.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Biopsy; Gentamicins; Humans; Male; Methicillin-Resi | 2010 |
[A neonatal case of immunoallergic acute interstitial nephritis].
Topics: Acute Disease; Anti-Bacterial Agents; Cefotaxime; Eosinophilia; Gentamicins; Hepatitis; Humans; Infa | 2010 |
Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats.
Topics: Administration, Oral; Animals; Gentamicins; Gum Arabic; Injections, Intraperitoneal; Kidney Tubules, | 2002 |
Inhibition of nuclear factor-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin.
Topics: Animals; Creatinine; Female; Gentamicins; Immunohistochemistry; Kidney; Kidney Cortex; Macrophages; | 2004 |
Effect of nephrotoxins on tubulointerstitial injury and NF-kappaB activation in Adriamycin nephropathy.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Ferr | 2005 |
Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Creatinine; Female; Fibrosis; Gentamicins; Immuno | 2006 |
Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Apoptosis; Blood Pressure; Blood Urea Nitrogen; | 2008 |
Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy.
Topics: Acetaminophen; Acute Disease; Adult; Ampicillin; Anti-Infective Agents, Urinary; Bendroflumethiazide | 1983 |
The pathology of acute renal failure due to interstitial nephritis in man with comments on the role of interstitial inflammation and sex in gentamicin nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Creatinine; Female; Fluorescent Antibody Technique; Gentamicins; Human | 1982 |
Natural history of aminoglycoside nephrotoxicity in the dog.
Topics: Animals; Dogs; Electrolytes; Gentamicins; Glomerular Filtration Rate; Glucose; Glycosuria; Kidney Tu | 1980 |
Acute interstitial nephritis associated with gentamicin and lincomycin therapy.
Topics: Acute Disease; Aged; Female; Gentamicins; Humans; Kidney Tubules; Lincomycin; Nephritis, Interstitia | 1980 |
Urine profiles and kidney histologic findings after intravenous injection of mannitol and iohexol in the degeneration phase of gentamicin nephropathy in rats.
Topics: Animals; Blood Chemical Analysis; Disease Models, Animal; Gentamicins; Injections, Intravenous; Iohe | 1993 |
[The nephrotoxicity of the methicillin-gentamycin combination. Apropos of 5 cases].
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Eosinophilia; Fever; Gentamicins; Hematuria; Hum | 1976 |
Recurrent acute renal failure due to antibiotic-induced interstitial nephritis.
Topics: Acute Kidney Injury; Drug Combinations; Gentamicins; Humans; Male; Middle Aged; Nephritis, Interstit | 1979 |
Antibiotic-induced interstitial nephritis?
Topics: Drug Combinations; Gentamicins; Humans; Male; Nephritis, Interstitial; Sulfamethoxazole; Trimethopri | 1979 |
Antibiotic-induced interstitial nephritis?
Topics: Gentamicins; Humans; Kidney; Nephritis, Interstitial | 1979 |
Ampicillin sodium and nephrotoxicity.
Topics: Acute Kidney Injury; Ampicillin; Gentamicins; Humans; Kidney; Nephritis, Interstitial | 1977 |
Chronic tubulointerstitial nephritis and renal insufficiency associated with long-term "subtherapeutic" gentamicin.
Topics: Animals; Autoradiography; Gentamicins; Glomerular Filtration Rate; Inulin; Kidney Failure, Chronic; | 1988 |
[Acute interstitial nephritis following the use of gentamycin].
Topics: Acute Disease; Gentamicins; Humans; Male; Middle Aged; Nephritis, Interstitial; Time Factors | 1986 |
Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection.
Topics: Acute Disease; Aged; Creatinine; Drug Synergism; Gentamicins; Humans; Male; Mezlocillin; Nafcillin; | 1985 |
[Tubulointerstitial nephropathies due to antibiotics].
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Cephalexin; Cephaloridine; Cephalothin; Drug Hypersensit | 1973 |
Nephropathy associated with methicillin administration.
Topics: Acidosis; Aged; Biopsy; Chlorides; Eosinophilia; Female; Gentamicins; Humans; Immunoglobulins; Kanam | 1974 |
Penicillin-related nephritis and myocarditis: a case report.
Topics: Aged; Ampicillin; Cephalothin; Chloramphenicol; Gentamicins; Humans; Kidney; Male; Myocarditis; Myoc | 1971 |
[Study of the nephrotoxicity of gentamicin in humans].
Topics: Adult; Aged; Female; Gentamicins; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Male; Midd | 1971 |