gentamicin and Inner Ear Disease studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

Excerpt	Relevance	Reference
" Serum levels of gentamicin should be maintained within therapeutic ranges but below toxic levels."	5.27	Gentamicin-induced ototoxicity complicating treatment of chronic osteomyelitis. ( Bednar, J; Esterhai, JL; Kimmelman, CP, 1986)
"We have recently developed a novel inner ear drug delivery system using chitosan glycerophosphate (CGP) hydrogel loaded with drugs commonly used for treatment of inner ear diseases, significantly improving the drugs' sustained delivery."	3.79	A regulated delivery system for inner ear drug application. ( Bezpalko, O; Bur, A; Chi, FL; Gu, R; Han, Z; Lajud, SA; Li, D; Nagda, DA; O'Malley, BW; Sanyal, S, 2013)
"Histological evaluation of vestibular and cochlear damage was performed on Mongolian gerbils after a known dosage of gentamicin in different delivery vehicles."	1.32	Direct round window application of gentamicin with varying delivery vehicles: a comparison of ototoxicity. ( Pack, A; Sheppard, WM; Slepecky, N; Wanamaker, HH; Yamamoto, S, 2004)
"Dibekacin-treated animals showed a significant (P less than 0."	1.27	Comparative ototoxicity of dibekacin and netilmicin in guinea pigs. ( Arpini, A; Forlani, A; Marzanatti, M; Parravicini, L, 1983)
" Serum levels of gentamicin should be maintained within therapeutic ranges but below toxic levels."	1.27	Gentamicin-induced ototoxicity complicating treatment of chronic osteomyelitis. ( Bednar, J; Esterhai, JL; Kimmelman, CP, 1986)
" Dosage of gentamicin sulfate was 1."	1.26	Vestibular toxicity of gentamicin. Incidence in patients receiving long-term hemodialysis therapy. ( Dominguez-Moreno, M; Gailiunas, P; Gottlieb, MN; Lazarus, M; Lowrie, EG; Merrill, JP, 1978)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (84.48)	18.7374
1990's	2 (3.45)	18.2507
2000's	4 (6.90)	29.6817
2010's	3 (5.17)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Haran, FJ	1
Keshner, EA	1
Faucher, K	1
Aas-Hansen, Ø	1
Damsgård, B	1
Laukli, E	1
Stenklev, NC	1
McCall, AA	1
Swan, EE	1
Borenstein, JT	1
Sewell, WF	1
Kujawa, SG	1
McKenna, MJ	1
Salt, A	1
Lajud, SA	1
Han, Z	2
Chi, FL	1
Gu, R	1
Nagda, DA	1
Bezpalko, O	1
Sanyal, S	1
Bur, A	1
O'Malley, BW	1
Li, D	1
JAO, RL	1
JACKSON, GG	2
Sheppard, WM	1
Wanamaker, HH	1
Pack, A	1
Yamamoto, S	1
Slepecky, N	1
Liu, Y	1
Sun, JJ	1
Yokota, M	1
Takeda, U	1
Sakamoto, K	1
Seto, N	1
Igarashi, M	1
Johnsson, LG	3
Hawkins, JE	3
Kingsley, TC	1
Black, FO	1
Matz, GJ	1
Wilson, WR	1
Wilkowske, CJ	1
Wright, AJ	1
Sande, MA	1
Geraci, JE	1
Longridge, NS	1
Mallinson, AI	1
Parravicini, L	1
Forlani, A	1
Marzanatti, M	1
Arpini, A	1
Vergnon, L	1
Fraisse, P	1
Bismuth, A	1
Bismuth, C	1
Noone, P	1
Ramsden, RT	1
Ackrill, P	1
Eviatar, L	1
Eviatar, A	1
Proctor, LR	1
Tange, RA	2
Conijn, EA	1
van Zeijl, LG	1
Huizing, EH	3
Aran, JM	1
Schönenberger, U	1
Streit, C	1
Hoigné, R	1
Duckert, LG	1
Rubel, EW	2
Hybels, RL	1
Kollias, G	1
Lyon-Caen, O	1
Schwartz, FD	1
Gailiunas, P	1
Dominguez-Moreno, M	1
Lazarus, M	1
Lowrie, EG	1
Gottlieb, MN	1
Merrill, JP	1
Bernard, PA	1
Christensen, EF	1
Reiffenstein, JC	1
Madissoo, H	1
Magnusson, M	1
Padoan, S	1
Karlberg, M	1
Johansson, R	1
Brahams, D	1
Marra, TR	1
Reynolds, NC	1
Stoddard, JJ	1
Esterhai, JL	1
Bednar, J	1
Kimmelman, CP	1
Elidan, J	1
Lin, J	1
Honrubia, V	1
Hinojosa, R	1
Lerner, SA	1
Cruz, RM	1
Lambert, PR	1
Backus, RM	1
De Groot, JC	1
Buchanan, N	1
Ohtani, I	1
Ohtsuki, K	1
Aikawa, T	1
Sato, Y	1
Anzai, T	1
Ouchi, J	1
Saito, T	1
Bailey, RR	1
Lynn, KL	1
Paparella, MM	1
Ylikoski, J	3
Federspil, P	2
Wersäll, J	1
Björkroth, B	1
Flock, A	1
Lundquist, PG	1
Cox, CE	1
von Wasielewski, E	1
Bredehorst, HG	1
Falco, FG	1
Schwarz, GA	1
Blumenkrantz, MJ	1
Sundmäker, WL	1
Preston, RE	1
Arcieri, G	1
Küpper, K	1
Lange, G	1
Wysocki, S	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pharmacokinetics of Tobramycin Administered at the Beginning of Intermittent Hemodialysis Session[NCT03904836]			Phase 1	11 participants (Actual)	Interventional	2019-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Drug delivery for treatment of inner ear disease: current state of knowledge. Ear and hearing, 2010, Volume: 31, Issue:2 Topics: Anti-Bacterial Agents; Drug Delivery Systems; Gentamicins; Humans; Hydrogel, Polyethylene Glycol Dim	2010
[Progress in the study of administration of drugs of the inner ear]. Zhonghua yi xue za zhi, 2005, Jan-26, Volume: 85, Issue:4 Topics: Administration, Topical; Animals; Dexamethasone; Ear, Inner; Gentamicins; Humans; Labyrinth Diseases	2005
Gentamicin. The Medical clinics of North America, 1970, Volume: 54, Issue:5 Topics: Absorption; Drug Synergism; Enterobacteriaceae; Enterobacteriaceae Infections; Gentamicins; Humans;	1970
[Significant side effects of antibiotics]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1971, Volume: 77 Topics: Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Cephalosporins; Child; Child, Preschool; Ch	1971
Review of bacteriology and preclinical studies and clinical pharmacology of gentamicin sulfate. Therapeutische Umschau. Revue therapeutique, 1969 Topics: Animals; Cats; Clinical Trials as Topic; Cochlea; Enterobacter; Enterobacteriaceae; Escherichia coli	1969

Article	Year
[Approach to cochleovestibular tolerability of aminoglycosides in man. Demonstration of a methodology apropos of a controlled comparative trial of dibekacin versus gentamicin]. La Nouvelle presse medicale, 1982, Nov-18, Volume: 11, Issue:46 Topics: Clinical Trials as Topic; Cochlea; Dibekacin; Gentamicins; Humans; Kanamycin; Labyrinth Diseases; Ve	1982
Review of bacteriology and preclinical studies and clinical pharmacology of gentamicin sulfate. Therapeutische Umschau. Revue therapeutique, 1969 Topics: Animals; Cats; Clinical Trials as Topic; Cochlea; Enterobacter; Enterobacteriaceae; Escherichia coli	1969

gentamicin and Inner Ear Disease

Research Excerpts

Research

Studies (58)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Sensory reweighting as a method of balance training for labyrinthine loss. Journal of neurologic physical therapy : JNPT, 2008, Volume: 32, Issue:4 Topics: Aged; Anti-Bacterial Agents; Female; Gentamicins; Humans; Kinesthesis; Labyrinth Diseases; Physical	2008
Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin. International journal of audiology, 2009, Volume: 48, Issue:7 Topics: Acoustic Maculae; Acoustic Stimulation; Analysis of Variance; Animals; Anti-Bacterial Agents; Audito	2009
Guest editorial: drug delivery for treatment of inner ear disease: current state of knowledge. Ear and hearing, 2010, Volume: 31, Issue:2 Topics: Anti-Bacterial Agents; Drug Delivery Systems; Gentamicins; Humans; Labyrinth Diseases	2010
A regulated delivery system for inner ear drug application. Journal of controlled release : official journal of the Controlled Release Society, 2013, Mar-28, Volume: 166, Issue:3 Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Chitosan; Delayed-Action Preparations; Drug Carri	2013
GENTAMICIN SULFATE, NEW ANTIBIOTIC AGAINST GRAM-NEGATIVE BACILLI. LABORATORY, PHARMACOLOGICAL, AND CLINICAL EVALUATION. JAMA, 1964, Sep-14, Volume: 189 Topics: Adolescent; Anti-Bacterial Agents; Biomedical Research; Blood; Child; Drug Therapy; Escherichia coli	1964
Direct round window application of gentamicin with varying delivery vehicles: a comparison of ototoxicity. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2004, Volume: 131, Issue:6 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Drug Delivery Systems; Fibrin; Gelatin Spon	2004
The comparative ototoxicities of panimycin and gentamicin in cynomolgus monkeys (Macaca fascicularis). Chemotherapy, 1984, Volume: 30, Issue:4 Topics: Acoustic Maculae; Aminoglycosides; Animals; Body Weight; Dibekacin; Female; Gentamicins; Kanamycin;	1984
Aminoglycoside-induced cochlear pathology in man. Acta oto-laryngologica. Supplementum, 1981, Volume: 383 Topics: Adult; Amikacin; Aminoglycosides; Anti-Bacterial Agents; Child; Cochlea; Female; Gentamicins; Hair C	1981
Treatment of streptomycin-susceptible and streptomycin-resistant enterococcal endocarditis. Annals of internal medicine, 1984, Volume: 100, Issue:6 Topics: Adult; Aged; Drug Therapy, Combination; Endocarditis, Bacterial; Enterococcus faecalis; Female; Gent	1984
A discussion of the dynamic illegible "E" test: a new method of screening for aminoglycoside vestibulotoxicity. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1984, Volume: 92, Issue:6 Topics: Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Female; Gentamicins; Head; Humans; Labyrinth Di	1984
Comparative ototoxicity of dibekacin and netilmicin in guinea pigs. Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:3 Topics: Action Potentials; Animals; Auditory Threshold; Cochlea; Dibekacin; Evoked Potentials, Auditory; Fem	1983
Clinical application of aminoglycosides. British journal of audiology, 1982, Volume: 16, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; Gentamicins; Humans; Kidney Diseases; Labyrinth Diseases; La	1982
Bobbing oscillopsia from gentamicin toxicity. British journal of audiology, 1982, Volume: 16, Issue:2 Topics: Gentamicins; Humans; Kidney Failure, Chronic; Labyrinth Diseases; Renal Dialysis; Vestibule, Labyrin	1982
Development of head control and vestibular responses in infants treated with aminoglycosides. Developmental medicine and child neurology, 1982, Volume: 24, Issue:3 Topics: Cerebral Palsy; Female; Follow-Up Studies; Gentamicins; Humans; Infant; Infant, Newborn; Infant, Pre	1982
Disability from aminoglycoside-induced vestibular paralysis. The Johns Hopkins medical journal, 1982, Volume: 151, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Gentamicins; Humans; Labyrinth Diseases; Male; Middle Aged;	1982
Pattern of gentamicin-induced cochlear degeneration in the guinea pig. A morphological and electrophysiological study. Archives of oto-rhino-laryngology, 1982, Volume: 236, Issue:2 Topics: Animals; Audiometry; Audiometry, Evoked Response; Auditory Threshold; Cochlea; Gentamicins; Guinea P	1982
[Evaluation of the ototoxicity of aminoglycosides. Comparative study of dibekacin, gentamicin and tobramycin]. La Nouvelle presse medicale, 1982, Nov-18, Volume: 11, Issue:46 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Dibekacin; Evaluation Studies as Topic; Gentamicins	1982
[Nephro- and ototoxicity of aminoglycoside-antibiotics, with special reference to gentamicin (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1981, Jan-27, Volume: 70, Issue:5 Topics: Acute Kidney Injury; Aminoglycosides; Dose-Response Relationship, Drug; Drug Interactions; Gentamici	1981
Morphological correlates of functional recovery in the chicken inner ear after gentamycin treatment. The Journal of comparative neurology, 1993, May-01, Volume: 331, Issue:1 Topics: Animals; Animals, Newborn; Chickens; Cochlea; Ear, Inner; Gentamicins; Hair Cells, Auditory; Labyrin	1993
Drug toxicity of the inner ear. The Medical clinics of North America, 1979, Volume: 63, Issue:2 Topics: Animals; Chloroquine; Dihydrostreptomycin Sulfate; Ethacrynic Acid; Furosemide; Gentamicins; Humans;	1979
[Gentamicin therapy in 1272 hospitalized patients with urinary tract infections. Clinical study]. MMW, Munchener medizinische Wochenschrift, 1979, Feb-09, Volume: 121, Issue:6 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administrat	1979
[Cochleovestibular complications of gentamicin]. La Revue du praticien, 1978, Jan-01, Volume: 28, Issue:1 Topics: Cochlea; Gentamicins; Humans; Labyrinth Diseases; Vestibule, Labyrinth	1978
Vestibular toxicity of gentamicin in the presence of renal disease. Archives of internal medicine, 1978, Volume: 138, Issue:11 Topics: Gentamicins; Humans; Kidney Cortex; Kidney Diseases; Labyrinth Diseases; Renal Dialysis; Vestibule,	1978
Vestibular toxicity of gentamicin. Incidence in patients receiving long-term hemodialysis therapy. Archives of internal medicine, 1978, Volume: 138, Issue:11 Topics: Adult; Aged; Body Weight; Female; Gentamicins; Humans; Kidney Failure, Chronic; Labyrinth Diseases;	1978
Correlations between ultrastructural findings and electrocochleographic recordings in experimental aminoside intoxication. The Journal of otolaryngology, 1977, Volume: 6, Issue:6 Topics: Animals; Anti-Bacterial Agents; Cochlea; Endoplasmic Reticulum; Evoked Potentials; Gentamicins; Guin	1977
Comparative ototoxicity of amikacin and gentamicin in cats. Antimicrobial agents and chemotherapy, 1977, Volume: 12, Issue:2 Topics: Acoustic Stimulation; Action Potentials; Amikacin; Animals; Behavior, Animal; Cats; Ear Diseases; Fe	1977
Delayed onset of ototoxic effects of gentamicin in patients with Meniére's disease. Acta oto-laryngologica. Supplementum, 1991, Volume: 485 Topics: Adult; Audiometry, Pure-Tone; Caloric Tests; Cochlea; Electrooculography; Female; Gentamicins; Human	1991
Dosage of gentamicin and monitoring of blood levels: an action fails. Lancet (London, England), 1986, Jun-14, Volume: 1, Issue:8494 Topics: Drug Therapy, Combination; Endocarditis, Bacterial; Female; Gentamicins; Humans; Labyrinth Diseases;	1986
Subjective oscillopsia ("jiggling" vision) presumably due to aminoglycoside ototoxicity. A report of two cases. Journal of clinical neuro-ophthalmology, 1988, Volume: 8, Issue:1 Topics: Anti-Bacterial Agents; Drug Therapy, Combination; Female; Gentamicins; Humans; Labyrinth Diseases; L	1988
Gentamicin-induced ototoxicity complicating treatment of chronic osteomyelitis. Clinical orthopaedics and related research, 1986, Issue:209 Topics: Adult; Chronic Disease; Cochlea; Female; Gentamicins; Humans; Labyrinth Diseases; Male; Middle Aged;	1986
Vestibular ototoxicity of gentamicin assessed by the recording of a short-latency vestibular-evoked response in cats. The Laryngoscope, 1987, Volume: 97, Issue:7 Pt 1 Topics: Animals; Cats; Evoked Potentials; Gentamicins; Labyrinth Diseases; Reaction Time; Vestibule, Labyrin	1987
Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity. The Journal of infectious diseases, 1987, Volume: 156, Issue:3 Topics: Adult; Cochlea; Female; Gentamicins; Hair Cells, Auditory; Hearing Disorders; Humans; Labyrinth Dise	1987
Light microscopic evidence of hair cell regeneration after gentamicin toxicity in chick cochlea. Archives of otolaryngology--head & neck surgery, 1987, Volume: 113, Issue:10 Topics: Animals; Chickens; Cochlea; Gentamicins; Hair Cells, Auditory; Labyrinth Diseases; Regeneration	1987
Pathological findings in the human auditory system following long-standing gentamicin ototoxicity. Archives of oto-rhino-laryngology, 1987, Volume: 244, Issue:2 Topics: Adult; Audiometry, Pure-Tone; Cochlea; Gentamicins; Hearing Loss, Sensorineural; Humans; Injections,	1987
Aminoglycoside monitoring in neonates--a re-appraisal. Australian and New Zealand journal of medicine, 1985, Volume: 15, Issue:4 Topics: Amikacin; Aminoglycosides; Gentamicins; Humans; Infant, Newborn; Kidney Diseases; Labyrinth Diseases	1985
Low ototoxicity and its mechanism of netilmicin. ORL; journal for oto-rhino-laryngology and its related specialties, 1985, Volume: 47, Issue:2 Topics: Amikacin; Aminoglycosides; Animals; Dibekacin; Gentamicins; Hair Cells, Auditory; Kanamycin; Kidney;	1985
Letter: Serum levels of gentamicin after intravenous bolus injection. Lancet (London, England), 1974, Apr-20, Volume: 1, Issue:7860 Topics: Gentamicins; Humans; Injections, Intravenous; Labyrinth Diseases; Male; Methods; Time Factors; Vesti	1974
The dizzy patient. Postgraduate medicine, 1972, Volume: 52, Issue:2 Topics: Diazepam; Drainage; Ear; Ear Neoplasms; Ethacrynic Acid; Gentamicins; Hearing Disorders; Humans; Inf	1972
Correlative studies on the cochlear pathology and hearing loss in guinea-pigs after intoxication with ototoxic antibiotics. Acta oto-laryngologica. Supplementum, 1974, Volume: 326 Topics: Animals; Auditory Threshold; Cochlea; Depression, Chemical; Gentamicins; Guinea Pigs; Hearing; Heari	1974
Correlation between pure tone audiogram and cochlear pathology in guinea-pigs intoxicated with ototoxic antibiotics. Acta oto-laryngologica. Supplementum, 1974, Volume: 326 Topics: Animals; Audiometry; Auditory Threshold; Cochlea; Depression, Chemical; Dose-Response Relationship,	1974
Guinea-pig hair cell pathology from ototoxic antibiotics. Acta oto-laryngologica. Supplementum, 1974, Volume: 326 Topics: Animals; Cilia; Cochlea; Depression, Chemical; Dose-Response Relationship, Drug; Epithelial Cells; E	1974
[Registration of cochlear damage in guinea pigs]. Zeitschrift fur Laryngologie, Rhinologie, Otologie und ihre Grenzgebiete, 1972, Volume: 51, Issue:9 Topics: Animals; Cochlea; Dimercaprol; Gentamicins; Guinea Pigs; Labyrinth Diseases; Methods; Microscopy, Ph	1972
Experiments on ototoxic effects of antibiotics. Advances in oto-rhino-laryngology, 1973, Volume: 20 Topics: Animals; Cochlea; Cytoplasm; Disease Models, Animal; Ear, Middle; Gentamicins; Guinea Pigs; Histolog	1973
Neurologic complications of malignant external otitis. Neurology, 1971, Volume: 21, Issue:11 Topics: Abducens Nerve; Aged; Carbenicillin; Cranial Nerves; Deafness; Diabetes Complications; Facial Paraly	1971
[Deafness and equilibrium disorders caused by gentamicin]. Nederlands tijdschrift voor geneeskunde, 1972, Jul-22, Volume: 116, Issue:30 Topics: Adult; Deafness; Female; Gentamicins; Humans; Labyrinth Diseases; Male; Middle Aged	1972
Cochlear microvasculature in normal and damaged ears. The Laryngoscope, 1972, Volume: 82, Issue:7 Topics: Capillaries; Cochlea; Ear; Gentamicins; Hearing Loss, Noise-Induced; Humans; Labyrinth Diseases; Mic	1972
Strial atrophy in clinical and experimental deafness. The Laryngoscope, 1972, Volume: 82, Issue:7 Topics: Animals; Atrophy; Basement Membrane; Blood Vessels; Cochlea; Deafness; Dogs; Ethacrynic Acid; Gentam	1972
Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States. The Journal of infectious diseases, 1971, Volume: 124 Suppl Topics: Adult; Age Factors; Body Weight; Ear, Inner; Gentamicins; Hearing Disorders; Humans; Kidney Diseases	1971
[Review of observed gentamicin ototoxicity cases in Germany]. HNO, 1971, Volume: 19, Issue:11 Topics: Adolescent; Adult; Aged; Diabetes Complications; Drug Synergism; Ethacrynic Acid; Gentamicins; Germa	1971
[Ototoxic effect of gentamicin in humans]. Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde, 1969, Dec-22, Volume: 194, Issue:2 Topics: Adolescent; Aged; Gentamicins; Hearing Disorders; Humans; Labyrinth Diseases; Male; Vestibule, Labyr	1969
[Gentamycin induced lesions of the vestibular organ in guinea pigs(cytovestibulogram calorization) and after its therapeutic administration]. Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde, 1970, Volume: 196, Issue:2 Topics: Adult; Animals; Calorimetry; Female; Gentamicins; Glomerulonephritis; Guinea Pigs; Humans; Labyrinth	1970
[Gentamycin in surgery]. Deutsche medizinische Wochenschrift (1946), 1969, Volume: 94, Issue:2 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Resistance, Microbial; Exanthema; Female; Gen	1969