Page last updated: 2024-10-27

gentamicin and Hypoxia

gentamicin has been researched along with Hypoxia in 25 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"We utilized a newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC) to investigate the effects of omeprazole and/or gentamicin on the formation of free oxygen radicals (FOR) and bowel histopathology."7.73Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats. ( Aritürk, E; Aydin, BK; Aydin, O; Bernay, F; Biçakçi, U; Eren, Z; Rizalar, R; Tander, B, 2005)
" We used our well-established global hypoxia-asphyxia newborn pig model to evaluate the effect of mild hypothermia after hypoxia-ischemia on gentamicin pharmacokinetics."7.70Influence of mild hypothermia after hypoxia-ischemia on the pharmacokinetics of gentamicin in newborn pigs. ( Hoem, NO; Lindgren, CG; Melby, K; Porter, H; Satas, S; Thoresen, M; Whitelaw, A, 2000)
"In an attempt to assess the erythropoietin (Epo) production site(s) in rat kidney, Epo response to hypoxia and renal histopathological changes were studied in rats administered with graded doses of gentamicin."7.69Erythropoietin response to acute hypobaric or anaemic hypoxia in gentamicin-administered rats. ( Enoki, Y; Kohzuki, H; Matsumura, K; Ohga, Y; Sakata, S; Shimizu, S, 1994)
"The activity of gentamicin is known to be decreased in acidic environments, and both the peritoneum during peritonitis and the interior of abscesses have been shown to be acidic and hypoxic."7.69Aztreonam vs. gentamicin in experimental peritonitis and intra-abdominal abscess formation. ( Adams, RB; Pruett, TL; Sawyer, RG, 1994)
" Toxicity is dose related, but some patients may still develop hearing loss even under safe dosage."5.37Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway. ( Hsu, CJ; Kao, MC; Lai, CH; Lin, CD; Lin, CW; Lin, CY; Tang, CH; Tsai, MH; Wei, IH, 2011)
"Toxic renal failure induced by gentamicin, glycerol, or cisplatin, as well as ischemic renal failure in vivo and hypoxia/reoxygenation of tubular epithelial cells in vitro, induces the production of reactive oxygen metabolites (ROM)."4.81Apoptotic pathways of oxidative damage to renal tubular epithelial cells. ( Basnakian, AG; Kaushal, GP; Shah, SV, 2002)
"We utilized a newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC) to investigate the effects of omeprazole and/or gentamicin on the formation of free oxygen radicals (FOR) and bowel histopathology."3.73Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats. ( Aritürk, E; Aydin, BK; Aydin, O; Bernay, F; Biçakçi, U; Eren, Z; Rizalar, R; Tander, B, 2005)
" We used our well-established global hypoxia-asphyxia newborn pig model to evaluate the effect of mild hypothermia after hypoxia-ischemia on gentamicin pharmacokinetics."3.70Influence of mild hypothermia after hypoxia-ischemia on the pharmacokinetics of gentamicin in newborn pigs. ( Hoem, NO; Lindgren, CG; Melby, K; Porter, H; Satas, S; Thoresen, M; Whitelaw, A, 2000)
"In an attempt to assess the erythropoietin (Epo) production site(s) in rat kidney, Epo response to hypoxia and renal histopathological changes were studied in rats administered with graded doses of gentamicin."3.69Erythropoietin response to acute hypobaric or anaemic hypoxia in gentamicin-administered rats. ( Enoki, Y; Kohzuki, H; Matsumura, K; Ohga, Y; Sakata, S; Shimizu, S, 1994)
"The activity of gentamicin is known to be decreased in acidic environments, and both the peritoneum during peritonitis and the interior of abscesses have been shown to be acidic and hypoxic."3.69Aztreonam vs. gentamicin in experimental peritonitis and intra-abdominal abscess formation. ( Adams, RB; Pruett, TL; Sawyer, RG, 1994)
"5 mM), gentamicin (4 mM), and hypoxia; altered inotropic reactivity to these interventions followed similar temporal development as the postendotoxin changes in basal contractile parameters."3.67Development of myocardial dysfunction in endotoxin shock. ( Adams, HR; Parker, JL, 1985)
"Infants that succumb to Sudden Infant Death Syndrome (SIDS) have been identified with inner ear dysfunction (IED) at birth and on autopsy."1.43Inner ear lesion and the differential roles of hypoxia and hypercarbia in triggering active movements: Potential implication for the Sudden Infant Death Syndrome. ( Allen, T; Chae, Y; Ramirez, JM; Ramirez, S; Rubens, DD; Villagracia, L, 2016)
" Toxicity is dose related, but some patients may still develop hearing loss even under safe dosage."1.37Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway. ( Hsu, CJ; Kao, MC; Lai, CH; Lin, CD; Lin, CW; Lin, CY; Tang, CH; Tsai, MH; Wei, IH, 2011)
"The effect of anoxia persisted, although less remarkable (P=0."1.31Netilmicin effect on urinary retinol binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia. ( Cataldi, L; Fanos, V; Mussap, M; Plebani, M; Verlato, G, 2002)
"Cardiac effects of endotoxin shock were compared in left atrial preparations isolated from guinea pigs and rats injected with 4 or 8 mg/kg E coli endotoxin."1.27Contractile function of heart muscle isolated from endotoxin-shocked guinea pigs and rats. ( Parker, JL, 1983)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19909 (36.00)18.7374
1990's6 (24.00)18.2507
2000's7 (28.00)29.6817
2010's3 (12.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allen, T2
Garcia Iii, AJ1
Tang, J1
Ramirez, JM2
Rubens, DD2
Ramirez, S1
Villagracia, L1
Chae, Y1
Lin, CD1
Kao, MC1
Tsai, MH2
Lai, CH1
Wei, IH1
Tang, CH1
Lin, CW1
Hsu, CJ1
Lin, CY1
Basnakian, AG1
Kaushal, GP1
Shah, SV1
Healy, CM1
Palazzi, DL1
Edwards, MS1
Campbell, JR1
Baker, CJ1
Yarin, YM1
Amarjargal, N1
Fuchs, J1
Haupt, H1
Mazurek, B1
Morozova, SV1
Gross, J1
Biçakçi, U1
Tander, B1
Aritürk, E1
Aydin, BK1
Aydin, O1
Rizalar, R1
Eren, Z1
Bernay, F1
Guignard, JP1
Parker, JL2
Weismann, D1
Herrig, J1
McWeeny, O1
Shimizu, S1
Enoki, Y1
Sakata, S1
Kohzuki, H1
Ohga, Y1
Matsumura, K1
Sawyer, RG1
Adams, RB1
Pruett, TL1
Kawashiro, N1
Tsuchihashi, N1
Koga, K1
Ito, Y1
Kawano, H1
Kalaidjieva, V1
Satas, S1
Hoem, NO1
Melby, K1
Porter, H1
Lindgren, CG1
Whitelaw, A1
Thoresen, M1
Kalaidjieva, VC1
Iliev, ZK1
Chen, B1
Jia, C1
Su, Y1
Cataldi, L1
Mussap, M1
Verlato, G1
Plebani, M1
Fanos, V1
Mirhij, NJ1
Roberts, RJ1
Myers, MG1
Ledingham, IM1
Whitehead, ML1
Lonsbury-Martin, BL1
Martin, GK1
Jelkmann, W1
Marienhoff, N1
Giesselmann, S1
Busch, L1
Adams, HR1
Takada, A1
Bledsoe, S1
Schacht, J1
Abbate, EH1
Roncoroni, AJ1

Reviews

1 review available for gentamicin and Hypoxia

ArticleYear
Apoptotic pathways of oxidative damage to renal tubular epithelial cells.
    Antioxidants & redox signaling, 2002, Volume: 4, Issue:6

    Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Cisplatin; Endonucleases; Enzyme Activation; Enzym

2002

Other Studies

24 other studies available for gentamicin and Hypoxia

ArticleYear
Inner ear insult ablates the arousal response to hypoxia and hypercarbia.
    Neuroscience, 2013, Dec-03, Volume: 253

    Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Bacterial Agents; Arousal; Disease Models, Ani

2013
Inner ear lesion and the differential roles of hypoxia and hypercarbia in triggering active movements: Potential implication for the Sudden Infant Death Syndrome.
    Neuroscience, 2016, Nov-19, Volume: 337

    Topics: Animals; Arousal; Ear, Inner; Female; Gentamicins; Humans; Hypercapnia; Hypoxia; Infant; Male; Mice;

2016
Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway.
    Laboratory investigation; a journal of technical methods and pathology, 2011, Volume: 91, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Blotting, Western; Caspases; Cell Line; Cochlea; Disease

2011
Features of invasive staphylococcal disease in neonates.
    Pediatrics, 2004, Volume: 114, Issue:4

    Topics: Age of Onset; Anti-Bacterial Agents; Catheters, Indwelling; Coagulase; Cohort Studies; Drug Resistan

2004
Argon protects hypoxia-, cisplatin- and gentamycin-exposed hair cells in the newborn rat's organ of Corti.
    Hearing research, 2005, Volume: 201, Issue:1-2

    Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Antineoplastic Agents; Argon; Case-Control Studies

2005
Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats.
    Pediatric surgery international, 2005, Volume: 21, Issue:10

    Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Enteroc

2005
Drugs and the neonatal kidney.
    Developmental pharmacology and therapeutics, 1982, Volume: 4 Suppl

    Topics: Asphyxia Neonatorum; Captopril; Gentamicins; Humans; Hypoxia; Indomethacin; Infant, Newborn; Infant,

1982
Contractile function of heart muscle isolated from endotoxin-shocked guinea pigs and rats.
    Advances in shock research, 1983, Volume: 9

    Topics: Animals; Calcium; Gentamicins; Guinea Pigs; Heart Atria; Hypoxia; Male; Myocardial Contraction; Rats

1983
Tissue distribution of gentamicin in lambs: effect of postnatal age and acute hypoxemia.
    Developmental pharmacology and therapeutics, 1982, Volume: 5, Issue:3-4

    Topics: Aging; Animals; Blood Gas Analysis; Gentamicins; Hematocrit; Hypoxia; Regional Blood Flow; Sheep; Ti

1982
Erythropoietin response to acute hypobaric or anaemic hypoxia in gentamicin-administered rats.
    Acta physiologica Scandinavica, 1994, Volume: 151, Issue:2

    Topics: Anemia; Animals; Atmospheric Pressure; Blood Volume; Erythropoietin; Gentamicins; Hypoxia; Kidney Tu

1994
Aztreonam vs. gentamicin in experimental peritonitis and intra-abdominal abscess formation.
    The American surgeon, 1994, Volume: 60, Issue:11

    Topics: Abdominal Abscess; Animals; Aztreonam; Bacteroides fragilis; Bacteroides Infections; beta-Lactam Res

1994
Idiopathic deafness or hearing loss of unknown etiology following discharge from the NICU.
    Acta oto-laryngologica. Supplementum, 1994, Volume: 514

    Topics: Child, Preschool; Deafness; Dyspnea; Evoked Potentials, Auditory, Brain Stem; Extracorporeal Membran

1994
Development of bone marrow erythroblastic islands in hypoxic rats with intact or damaged kidney tubules.
    Methods and findings in experimental and clinical pharmacology, 1998, Volume: 20, Issue:10

    Topics: Animals; Bone Marrow; Creatinine; Erythroblasts; Erythropoietin; Gentamicins; Hypoxia; Kidney Diseas

1998
Influence of mild hypothermia after hypoxia-ischemia on the pharmacokinetics of gentamicin in newborn pigs.
    Biology of the neonate, 2000, Volume: 77, Issue:1

    Topics: Animals; Animals, Newborn; Blood Glucose; Creatinine; Female; Fluorescence Polarization Immunoassay;

2000
Plasma erythropoietin level in rats after kidney proximal tubular impairment.
    Folia medica, 2000, Volume: 42, Issue:3

    Topics: Anemia; Animals; Disease Models, Animal; Erythropoiesis; Erythropoietin; Gentamicins; Hematologic Te

2000
[Experience in the management of severe inhalation injury].
    Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns, 1999, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Bronchoalveolar Lavage; Burns, Inhalation; Child; Child, Preschool; Dexamethasone

1999
Netilmicin effect on urinary retinol binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia.
    Journal of chemotherapy (Florence, Italy), 2002, Volume: 14, Issue:1

    Topics: Acetylglucosaminidase; Female; Gentamicins; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Mal

2002
Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals.
    Antimicrobial agents and chemotherapy, 1978, Volume: 14, Issue:3

    Topics: Amikacin; Animals; Animals, Newborn; Gentamicins; Half-Life; Hypoxia; Kanamycin; Male; Rabbits; Rats

1978
Septic shock.
    The British journal of surgery, 1975, Volume: 62, Issue:10

    Topics: Acid-Base Equilibrium; Adult; Bacteroides; Blood Coagulation Tests; Digitalis Glycosides; Disseminat

1975
Evidence for two discrete sources of 2f1-f2 distortion-product otoacoustic emission in rabbit. II: Differential physiological vulnerability.
    The Journal of the Acoustical Society of America, 1992, Volume: 92, Issue:5

    Topics: Acoustic Stimulation; Acoustics; Animals; Audiometry; Auditory Fatigue; Cadaver; Ethacrynic Acid; Ge

1992
Lowered plasma erythropoietin in hypoxic rats with kidney tubule lesions.
    Blut, 1988, Volume: 57, Issue:5

    Topics: Altitude; Animals; Cell Line; Erythropoietin; Gentamicins; Hydronephrosis; Hypoxia; Kidney Tubular N

1988
Development of myocardial dysfunction in endotoxin shock.
    The American journal of physiology, 1985, Volume: 248, Issue:6 Pt 2

    Topics: Animals; Calcium; Gentamicins; Guinea Pigs; Heart; Hypoxia; Male; Muscle Contraction; Myocardial Con

1985
An energy-dependent step in aminoglycoside ototoxicity: prevention of gentamicin ototoxicity during reduced endolymphatic potential.
    Hearing research, 1985, Volume: 19, Issue:3

    Topics: Aminoglycosides; Aminooxyacetic Acid; Animals; Cochlear Microphonic Potentials; Ear Diseases; Endoly

1985
Functional changes in a patient with aspiration pneumonitis.
    Resuscitation, 1973, Volume: 2, Issue:1

    Topics: Aminophylline; Barbiturates; Cephalothin; Coma; Diuretics; Female; Gentamicins; Humans; Hyperventila

1973