gentamicin has been researched along with Heart Diseases in 10 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current guidelines recommend either ampicillin plus ceftriaxone (AC) or amoxicillin/ampicillin plus gentamicin (AG) with an equivalent class IB recommendation in Enterococcus faecalis endocarditis." | 9.22 | Time to abandon ampicillin plus gentamicin in favour of ampicillin plus ceftriaxone in Enterococcus faecalis infective endocarditis? A meta-analysis of comparative trials. ( Hoppe, UC; Lichtenauer, M; Mirna, M; Schmutzler, L; Topf, A, 2022) |
| "Current guidelines recommend either ampicillin plus ceftriaxone (AC) or amoxicillin/ampicillin plus gentamicin (AG) with an equivalent class IB recommendation in Enterococcus faecalis endocarditis." | 5.22 | Time to abandon ampicillin plus gentamicin in favour of ampicillin plus ceftriaxone in Enterococcus faecalis infective endocarditis? A meta-analysis of comparative trials. ( Hoppe, UC; Lichtenauer, M; Mirna, M; Schmutzler, L; Topf, A, 2022) |
| " In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis." | 3.80 | Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. ( Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mirna, M | 1 |
| Topf, A | 1 |
| Schmutzler, L | 1 |
| Hoppe, UC | 1 |
| Lichtenauer, M | 1 |
| Friberg, Ö | 1 |
| Bodin, L | 1 |
| Zhu, JJ | 1 |
| Xu, YQ | 1 |
| He, JH | 1 |
| Yu, HP | 1 |
| Huang, CJ | 1 |
| Gao, JM | 1 |
| Dong, QX | 1 |
| Xuan, YX | 1 |
| Li, CQ | 1 |
| Haessler, D | 1 |
| Reverdy, ME | 1 |
| Neidecker, J | 1 |
| Brûlé, P | 1 |
| Ninet, J | 1 |
| Lehot, JJ | 1 |
| Baer, DM | 1 |
| Jones, RN | 1 |
| Mullooly, JP | 1 |
| Horner, W | 1 |
| Just, HM | 1 |
| Eschenbruch, E | 1 |
| Schmuziger, M | 1 |
| Daschner, FD | 1 |
| Adams, HR | 1 |
| Parker, JL | 1 |
| Durrett, LR | 1 |
| Conio, S | 1 |
| Bello, A | 1 |
| Fazzi, O | 1 |
| Dettli, LC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1, Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of a Single 3 Gram Dose of Cefazolin in Adult Subjects Weighing >= 120 kg Scheduled for Surgery[NCT05205486] | Phase 1 | 12 participants (Actual) | Interventional | 2022-04-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for gentamicin and Heart Diseases
| Article | Year |
|---|---|
Time to abandon ampicillin plus gentamicin in favour of ampicillin plus ceftriaxone in Enterococcus faecalis infective endocarditis? A meta-analysis of comparative trials.
Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Endocarditis | 2022 |
1 trial available for gentamicin and Heart Diseases
| Article | Year |
|---|---|
[Therapy with gentamicin in patients operated for heart diseases. Preliminary note].
Topics: Adult; Aged; Aortic Valve Insufficiency; Aortic Valve Stenosis; Clinical Trials as Topic; Extracorpo | 1973 |
8 other studies available for gentamicin and Heart Diseases
| Article | Year |
|---|---|
Collagen gentamicin for prevention of sternal wound infection: effective or not?
Topics: Administration, Topical; Aged; Anti-Bacterial Agents; Cardiac Surgical Procedures; Collagen; Drug Co | 2013 |
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease | 2014 |
Antibiotic prophylaxis with cefazolin and gentamicin in cardiac surgery for children less than ten kilograms.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Procedures; Cefazolin; Female; Genta | 2003 |
Protocol for the study of drug interferences in laboratory tests: cefotaxime interference in 24 clinical tests.
Topics: Blood Chemical Analysis; Cefotaxime; False Positive Reactions; Female; Gentamicins; Heart Diseases; | 1983 |
Penetration of netilmicin into heart valves, subcutaneous and muscular tissue of patients undergoing heart surgery.
Topics: Adipose Tissue; Gentamicins; Heart Diseases; Heart Valves; Humans; Muscles; Myocardium; Netilmicin; | 1983 |
Antibiotic prophylaxis for infective endocarditis. FDI Commission Working Group.
Topics: Adult; Amoxicillin; Ampicillin; Anti-Bacterial Agents; Anticoagulants; Bacteremia; Child; Clindamyci | 1994 |
Cardiac toxicities of antibiotics.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium; Digoxin; Gentamicins; Guinea Pigs; Heart D | 1978 |
Drug dosage in patients with renal disease.
Topics: Anti-Bacterial Agents; Creatinine; Dosage Forms; Dose-Response Relationship, Drug; Gentamicins; Half | 1974 |