gentamicin and Head and Neck Neoplasms studies

gentamicin and Head and Neck Neoplasms

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Research Excerpts

Excerpt	Relevance	Reference
" There is no general agreement as to which antibiotic or combination of antibiotics to use or what the schedule of dosage administration should be."	2.65	Antimicrobial prophylaxis for contaminated head and neck surgery. ( Johnson, JT; Myers, EN; Schramm, VL; Sigler, BA; Thearle, PB, 1984)

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (50.00)	18.7374
1990's	2 (16.67)	18.2507
2000's	3 (25.00)	29.6817
2010's	1 (8.33)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

6 (50.00)

18.7374

1990's

2 (16.67)

18.2507

2000's

3 (25.00)

29.6817

2010's

1 (8.33)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Yang, CH	1
Chew, KY	1
Solomkin, JS	1
Lin, PY	1
Chiang, YC	1
Kuo, YR	1
El-Sayed, S	2
Nabid, A	1
Shelley, W	1
Hay, J	2
Balogh, J	1
Gelinas, M	1
MacKenzie, R	1
Read, N	1
Berthelet, E	1
Lau, H	1
Epstein, J	2
Delvecchio, P	1
Ganguly, PK	1
Wong, F	1
Burns, P	2
Tu, D	2
Pater, J	2
Duncan, GG	1
Epstein, JB	1
El Sayed, S	1
Bezjak, A	1
Ottaway, J	1
Johnson, JT	3
Myers, EN	2
Thearle, PB	1
Sigler, BA	1
Schramm, VL	1
Barton, RP	1
Moir, AA	1
Rodrigo, JP	1
Alvarez, JC	1
Gómez, JR	1
Suárez, C	1
Fernández, JA	1
Martínez, JA	1
Barry, B	1
Minish, E	1
Laukkanen, E	1
Goode, RL	1
Abramson, N	1
Fee, WE	1
Levine, P	1
Gasparović, S	1
Virag, M	1
Yu, VL	2
Wagner, RL	1

Studies

Yang, CH

Chew, KY

Solomkin, JS

Lin, PY

Chiang, YC

Kuo, YR

El-Sayed, S

Nabid, A

Shelley, W

Hay, J

Balogh, J

Gelinas, M

MacKenzie, R

Read, N

Berthelet, E

Lau, H

Epstein, J

Delvecchio, P

Ganguly, PK

Wong, F

Burns, P

Tu, D

Pater, J

Duncan, GG

Epstein, JB

El Sayed, S

Bezjak, A

Ottaway, J

Johnson, JT

Myers, EN

Thearle, PB

Sigler, BA

Schramm, VL

Barton, RP

Moir, AA

Rodrigo, JP

Alvarez, JC

Gómez, JR

Suárez, C

Fernández, JA

Martínez, JA

Barry, B

Minish, E

Laukkanen, E

Goode, RL

Abramson, N

Fee, WE

Levine, P

Gasparović, S

Virag, M

Yu, VL

Wagner, RL

Clinical Trials (3)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Randomized Evaluation of a Phytopharmaceutical in Prevention of Severe Oral Mucositis in Patients Receiving Radiotherapy for Oral Cavity, Oropharynx, Hypopharynx, or Cavum Cancer[NCT01066741]	Phase 3	78 participants (Actual)	Interventional	2009-05-31	Terminated (stopped due to insufficient recruitment, the planed sample size appears not achievable)
The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis[NCT04308161]	Phase 2	45 participants (Anticipated)	Interventional	2019-11-02	Recruiting
The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis[NCT03833570]	Phase 2	40 participants (Actual)	Interventional	2018-01-12	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Randomized Evaluation of a Phytopharmaceutical in Prevention of Severe Oral Mucositis in Patients Receiving Radiotherapy for Oral Cavity, Oropharynx, Hypopharynx, or Cavum Cancer[NCT01066741]

Phase 3

78 participants (Actual)

Interventional

2009-05-31

Terminated (stopped due to insufficient recruitment, the planed sample size appears not achievable)

The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis[NCT04308161]

Phase 2

45 participants (Anticipated)

Interventional

2019-11-02

Recruiting

The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis[NCT03833570]

Phase 2

40 participants (Actual)

Interventional

2018-01-12

Completed

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

7 trials available for gentamicin and Head and Neck Neoplasms

Article	Year
Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis sc Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Oct-01, Volume: 20, Issue:19 Topics: Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacitracin; Clotrimazole;	2002
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head & neck, 2005, Volume: 27, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou	2005
Antimicrobial prophylaxis for contaminated head and neck surgery. The Laryngoscope, 1984, Volume: 94, Issue:1 Topics: Anti-Bacterial Agents; Cefazolin; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combination;	1984
Comparison of three prophylactic antibiotic regimens in clean-contaminated head and neck surgery. Head & neck, 1997, Volume: 19, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Antibiot	1997
A pilot study evaluating the safety and microbiologic efficacy of an economically viable antimicrobial lozenge in patients with head and neck cancer receiving radiation therapy. Head & neck, 2002, Volume: 24, Issue:1 Topics: Administration, Oral; Adult; Aged; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Female; Follo	2002
Antibiotic use during major head and neck surgery. Annals of surgery, 1988, Volume: 207, Issue:1 Topics: Anti-Bacterial Agents; Cefazolin; Cefoperazone; Cefotaxime; Clindamycin; Clinical Trials as Topic; D	1988
An assessment of the need for gram-negative bacterial coverage in antibiotic prophylaxis for oncological head and neck surgery. The Journal of infectious diseases, 1987, Volume: 155, Issue:2 Topics: Clindamycin; Double-Blind Method; Drug Therapy, Combination; Gentamicins; Gram-Negative Bacteria; He	1987

Article

Year

Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis sc

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Oct-01, Volume: 20, Issue:19

Topics: Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacitracin; Clotrimazole;

2002

Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.