Page last updated: 2024-10-27

gentamicin and Head and Neck Neoplasms

gentamicin has been researched along with Head and Neck Neoplasms in 12 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Research Excerpts

ExcerptRelevanceReference
" There is no general agreement as to which antibiotic or combination of antibiotics to use or what the schedule of dosage administration should be."2.65Antimicrobial prophylaxis for contaminated head and neck surgery. ( Johnson, JT; Myers, EN; Schramm, VL; Sigler, BA; Thearle, PB, 1984)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's2 (16.67)18.2507
2000's3 (25.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, CH1
Chew, KY1
Solomkin, JS1
Lin, PY1
Chiang, YC1
Kuo, YR1
El-Sayed, S2
Nabid, A1
Shelley, W1
Hay, J2
Balogh, J1
Gelinas, M1
MacKenzie, R1
Read, N1
Berthelet, E1
Lau, H1
Epstein, J2
Delvecchio, P1
Ganguly, PK1
Wong, F1
Burns, P2
Tu, D2
Pater, J2
Duncan, GG1
Epstein, JB1
El Sayed, S1
Bezjak, A1
Ottaway, J1
Johnson, JT3
Myers, EN2
Thearle, PB1
Sigler, BA1
Schramm, VL1
Barton, RP1
Moir, AA1
Rodrigo, JP1
Alvarez, JC1
Gómez, JR1
Suárez, C1
Fernández, JA1
Martínez, JA1
Barry, B1
Minish, E1
Laukkanen, E1
Goode, RL1
Abramson, N1
Fee, WE1
Levine, P1
Gasparović, S1
Virag, M1
Yu, VL2
Wagner, RL1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Evaluation of a Phytopharmaceutical in Prevention of Severe Oral Mucositis in Patients Receiving Radiotherapy for Oral Cavity, Oropharynx, Hypopharynx, or Cavum Cancer[NCT01066741]Phase 378 participants (Actual)Interventional2009-05-31Terminated (stopped due to insufficient recruitment, the planed sample size appears not achievable)
The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis[NCT04308161]Phase 245 participants (Anticipated)Interventional2019-11-02Recruiting
The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis[NCT03833570]Phase 240 participants (Actual)Interventional2018-01-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

7 trials available for gentamicin and Head and Neck Neoplasms

ArticleYear
Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis sc
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Oct-01, Volume: 20, Issue:19

    Topics: Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacitracin; Clotrimazole;

2002
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.
    Head & neck, 2005, Volume: 27, Issue:5

    Topics: Administration, Oral; Anti-Infective Agents; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Dou

2005
Antimicrobial prophylaxis for contaminated head and neck surgery.
    The Laryngoscope, 1984, Volume: 94, Issue:1

    Topics: Anti-Bacterial Agents; Cefazolin; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combination;

1984
Comparison of three prophylactic antibiotic regimens in clean-contaminated head and neck surgery.
    Head & neck, 1997, Volume: 19, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Antibiot

1997
A pilot study evaluating the safety and microbiologic efficacy of an economically viable antimicrobial lozenge in patients with head and neck cancer receiving radiation therapy.
    Head & neck, 2002, Volume: 24, Issue:1

    Topics: Administration, Oral; Adult; Aged; Bacitracin; Carcinoma, Squamous Cell; Clotrimazole; Female; Follo

2002
Antibiotic use during major head and neck surgery.
    Annals of surgery, 1988, Volume: 207, Issue:1

    Topics: Anti-Bacterial Agents; Cefazolin; Cefoperazone; Cefotaxime; Clindamycin; Clinical Trials as Topic; D

1988
An assessment of the need for gram-negative bacterial coverage in antibiotic prophylaxis for oncological head and neck surgery.
    The Journal of infectious diseases, 1987, Volume: 155, Issue:2

    Topics: Clindamycin; Double-Blind Method; Drug Therapy, Combination; Gentamicins; Gram-Negative Bacteria; He

1987

Other Studies

5 other studies available for gentamicin and Head and Neck Neoplasms

ArticleYear
Surgical site infections among high-risk patients in clean-contaminated head and neck reconstructive surgery: concordance with preoperative oral flora.
    Annals of plastic surgery, 2013, Volume: 71 Suppl 1

    Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Carcinoma, Squamous Cell; Clindamycin; F

2013
Use of a local gentamicin preparation ('Garamycin' Chains) as prophylaxis against infection in major head or neck surgery: a pilot study.
    Pharmatherapeutica, 1983, Volume: 3, Issue:5

    Topics: Administration, Topical; Adult; Aged; Female; Gentamicins; Head; Head and Neck Neoplasms; Humans; La

1983
Pharyngeal flora in patients undergoing head and neck oncologic surgery.
    Acta oto-rhino-laryngologica Belgica, 1999, Volume: 53, Issue:3

    Topics: Amoxicillin-Potassium Clavulanate Combination; Antibiotic Prophylaxis; Clindamycin; Gentamicins; Hea

1999
Effect of prophylactic antibiotics in radical head and neck surgery.
    The Laryngoscope, 1979, Volume: 89, Issue:4

    Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cefazolin; Cephalexin; Cephalosporins;

1979
[Comparison of a combination of clindamycin/gentamycin with metronidazole/gentamycin in surgery of the head and neck].
    Chirurgia maxillofacialis & plastica, 1988, Volume: 18, Issue:1-3

    Topics: Clindamycin; Drug Therapy, Combination; Gentamicins; Head and Neck Neoplasms; Humans; Infection Cont

1988