Page last updated: 2024-10-27

gentamicin and Gonorrhea

gentamicin has been researched along with Gonorrhea in 69 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Gonorrhea: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

Research Excerpts

ExcerptRelevanceReference
" Patients aged 15-60 years diagnosed with uncomplicated urogenital gonorrhea were randomly assigned to either gentamicin 240 mg intramuscularly plus azithromycin 2 g orally, or gemifloxacin 320 mg orally plus azithromycin 2 g orally."9.19The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea. ( Ghanem, KG; Hook, EW; Johnson, S; Kerndt, PR; Kirkcaldy, RD; Moore, PC; Papp, JR; Philip, SS; Weinstock, HS; Wiesenfeld, HC, 2014)
"The use of single-dose cefixime, ceftriaxone, and gentamicin-based regimens for treatment of gonorrhea appears to be safe and acceptable for use in practice."9.12Safety of Single-Dose Oral Cefixime, Intramuscular Ceftriaxone, or Intramuscular Gentamicin for the Treatment of Gonorrhea: A Systematic Review and Meta-analysis. ( Dresser, J; Wilby, KJ, 2021)
"Gentamicin-based regimens should be reserved for second-line treatment of urogenital and extragenital gonorrhea infections."9.05The Use of Gentamicin for Treatment of Urogenital and Extragenital Gonorrhea: A Systematic Review of Efficacy Data. ( Burmeister, P; Smith, AJ; Su, S; Wilby, KJ, 2020)
"Gentamicin has been used for the treatment of gonorrhea in Malawi since 1993."8.12Gentamicin Susceptibility in Neisseria gonorrhoeae and Treatment Outcomes for Urogenital Gonorrhea After 25 Years of Sustained Gentamicin Use in Malawi. ( Bonongwe, N; Chen, JS; Chikaonda, T; Cohen, MS; Golparian, D; Hobbs, MM; Hoffman, IF; Jere, E; Kamtambe, B; Krysiak, R; Massa, C; Mathiya, E; Matoga, M; Ndalama, B; Unemo, M, 2022)
" Patients aged 15-60 years diagnosed with uncomplicated urogenital gonorrhea were randomly assigned to either gentamicin 240 mg intramuscularly plus azithromycin 2 g orally, or gemifloxacin 320 mg orally plus azithromycin 2 g orally."5.19The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea. ( Ghanem, KG; Hook, EW; Johnson, S; Kerndt, PR; Kirkcaldy, RD; Moore, PC; Papp, JR; Philip, SS; Weinstock, HS; Wiesenfeld, HC, 2014)
"The use of single-dose cefixime, ceftriaxone, and gentamicin-based regimens for treatment of gonorrhea appears to be safe and acceptable for use in practice."5.12Safety of Single-Dose Oral Cefixime, Intramuscular Ceftriaxone, or Intramuscular Gentamicin for the Treatment of Gonorrhea: A Systematic Review and Meta-analysis. ( Dresser, J; Wilby, KJ, 2021)
"The efficacy and safety of piperacillin were compared with those of clindamycin plus gentamicin in 74 women with obstetric or gynecologic infections (such as endometritis, salpingitis and septic abortion)."5.06A comparison of piperacillin and clindamycin plus gentamicin in women with pelvic infections. ( Gunning, JE, 1986)
"Gentamicin-based regimens should be reserved for second-line treatment of urogenital and extragenital gonorrhea infections."5.05The Use of Gentamicin for Treatment of Urogenital and Extragenital Gonorrhea: A Systematic Review of Efficacy Data. ( Burmeister, P; Smith, AJ; Su, S; Wilby, KJ, 2020)
"Gentamicin has been used for the treatment of gonorrhea in Malawi since 1993."4.12Gentamicin Susceptibility in Neisseria gonorrhoeae and Treatment Outcomes for Urogenital Gonorrhea After 25 Years of Sustained Gentamicin Use in Malawi. ( Bonongwe, N; Chen, JS; Chikaonda, T; Cohen, MS; Golparian, D; Hobbs, MM; Hoffman, IF; Jere, E; Kamtambe, B; Krysiak, R; Massa, C; Mathiya, E; Matoga, M; Ndalama, B; Unemo, M, 2022)
"Centers for Disease Control and Prevention (CDC) guidelines recommend 240 mg gentamicin plus 2 g azithromycin for the treatment of gonorrhea in cephalosporin-allergic patients."3.96Gentamicin Alone Is Inadequate to Eradicate Neisseria Gonorrhoeae From the Pharynx. ( Barbee, LA; Bass, T; Golden, MR; Hughes, JP; Leclair, A; Morgan, J; Soge, OO; Werth, BJ, 2020)
" Based on clinical efficacy and cost, gentamicin 240 mg intramuscularly, and doxycycline 100 mg twice daily x 7 days was selected as the first line regimen to treat urethritis."3.76Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007. ( Banda, B; Brown, LB; Cohen, MS; Hobbs, M; Hoffman, IF; Hoffman, M; Hosseinipour, MC; Kamanga, G; Kamwendo, D; Kanyamula, H; Krysiak, R; Mapanje, C; Martinson, F; Mhango, C, 2010)
"Susceptibility of Neisseria gonorrhoeae to gentamicin, the primary treatment for gonorrhea in Malawi since 1993, was determined by using agar dilution MICs, E-test MICs, disc diffusion, and clinical cure rate."3.69Development of an antimicrobial susceptibility surveillance system for Neisseria gonorrhoeae in Malawi: comparison of methods. ( Cohen, MS; Daly, CC; Davis, R; Hobbs, M; Hoffman, I; Maida, M; Mughogho, G; Zimba, D, 1997)
"Men with urethritis due to Neisseria gonorrhoeae were treated with gentamicin, which is inactive against Chlamydia."3.65Infection with Chlamydia group A in men with urethritis due to Neisseria gonorrhoeae. ( Nicol, CS; Oriel, JD; Reeve, P; Thomas, BJ, 1975)
"The fosfomycin group was terminated early after interim analysis revealed less than 60% efficacy."3.11Efficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial. ( Boyd, A; de Korne-Elenbaas, J; de Laat, M; de Vries, HJC; Heijman, T; Jongen, VW; Schim van der Loeff, MF; van Dam, AP; Wind, CM, 2022)
"Gentamicin is a potential alternative treatment requiring further evaluation."2.90Gentamicin as an alternative to ceftriaxone in the treatment of gonorrhoea: the G-TOG non-inferiority RCT. ( Brittain, C; Cole, M; Dewsnap, C; Duley, L; Harding, J; Hepburn, T; Jackson, L; Lawrence, T; Meakin, G; Montgomery, AA; Roberts, T; Ross, JD; Sprange, K; Tan, W; Thandi, S; White, J; Wilson, J, 2019)
"If undetected and untreated, gonorrhea and chlamydia can lead to infertility, ectopic pregnancy, and chronic pelvic pain and can facilitate HIV acquisition and transmission."2.72Chlamydia and Gonorrhea. ( Dombrowski, JC, 2021)
"For gentamicin, there was 86."1.72Spectinomycin, gentamicin, and routine disc diffusion testing: An alternative for the treatment and monitoring of multidrug-resistant Neisseria gonorrhoeae? ( Barazzetti, FH; Bazzo, ML; de Albuquerque, VCB; de Melo Machado, H; Golfetto, L; Martins, JM; Santos, TMD; Scheffer, MC; Schörner, MA, 2022)
"No gentamicin resistance was detected in clinical isolates, 2015-2020, hence this is likely to be an available treatment option for resistant gonococcal infections in NSW."1.62Is gentamicin a viable therapeutic option for treating resistant Neisseria gonorrhoeae in New South Wales? ( Armstrong, BH; Driscoll, T; El Nasser, J; Hogan, T; Kundu, R; Lahra, MM; Lewis, DA; Limnios, A; Ray, S; Shoushtari, M, 2021)
" Gentamicin, an old and inexpensive antibiotic, is recommended in combination with azithromycin for treatment failures cases with the first-line regimen as per the latest Centers for Disease Control and Prevention sexually transmitted disease treatment guidelines."1.48In Vitro Synergy Testing of Gentamicin, an Old Drug Suggested as Future Treatment Option for Gonorrhoea, in Combination With Six Other Antimicrobials Against Multidrug-Resistant Neisseria gonorrhoeae Strains. ( Bala, M; Bhargava, A; Bhatnagar, R; Kakran, M; Singh, V, 2018)
"Cefixime resistance was detected in 2."1.48Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016. ( Amato-Gauci, AJ; Cole, MJ; Day, MJ; Jacobsson, S; Spiteri, G; Unemo, M; Woodford, N, 2018)
" An in vitro assessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections."1.42In vitro assessment of dual drug combinations to inhibit growth of Neisseria gonorrhoeae. ( Papp, JR; Pettus, K; Sharpe, S, 2015)
"Treatment with ampicillin, gentamicin, and clindamycin eliminated the infection, although uterine and adnexal tenderness persisted at the 6-week follow-up."1.28Gonococcal peritonitis after tubal ligation. A case report. ( Entman, SS; Weeks, AG, 1991)
"Gentamicin is a valuable alternative in the treatment of infections due to PPNG strains."1.26Gentamicin in the treatment of infections due to penicillinase-producing gonococci. ( Pang, R; Rajan, VS; Sng, EH; Tan, NJ, 1980)

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-199027 (39.13)18.7374
1990's4 (5.80)18.2507
2000's1 (1.45)29.6817
2010's20 (28.99)24.3611
2020's17 (24.64)2.80

Authors

AuthorsStudies
Dombrowski, JC1
Matoga, M2
Chen, JS1
Krysiak, R2
Ndalama, B1
Massa, C1
Bonongwe, N1
Mathiya, E1
Kamtambe, B1
Jere, E1
Chikaonda, T1
Golparian, D3
Unemo, M7
Cohen, MS3
Hobbs, MM1
Hoffman, IF3
de Vries, HJC1
de Laat, M1
Jongen, VW1
Heijman, T1
Wind, CM1
Boyd, A1
de Korne-Elenbaas, J1
van Dam, AP1
Schim van der Loeff, MF1
Holley, CL2
Dhulipala, V1
Balthazar, JT1
Le Van, A1
Begum, AA1
Chen, SC1
Read, TD1
Jerse, AE1
Shafer, WM2
Martins, JM1
Scheffer, MC1
de Melo Machado, H1
Schörner, MA1
Golfetto, L1
Santos, TMD1
Barazzetti, FH1
de Albuquerque, VCB1
Bazzo, ML1
Jacobsson, S2
Ayinde, O1
Ross, JDC3
Jackson, L3
Rob, F2
Klubalová, B1
Nyčová, E1
Hercogová, J1
Cole, MJ4
Tan, W4
Fifer, H1
Brittain, C4
Duley, L5
Hepburn, T4
Lawrence, T3
Montgomery, AA4
Sprange, K3
Thandi, S3
Churchward, C1
Tripodo, F1
Woodford, N2
Barbee, LA1
Soge, OO1
Morgan, J1
Leclair, A1
Bass, T1
Werth, BJ1
Hughes, JP1
Golden, MR1
Sfeir, MM1
Burmeister, P1
Su, S1
Smith, AJ1
Wilby, KJ2
Mensforth, S1
Ayinde, OC1
Ross, J1
Dresser, J1
Armstrong, BH1
Limnios, A1
Lewis, DA2
Hogan, T1
Kundu, R1
Ray, S1
Shoushtari, M1
El Nasser, J1
Driscoll, T1
Lahra, MM1
Allen, GP1
Deao, KM1
Hill, SA1
Schipelliti, SM1
Tran, T1
Singh, V2
Bala, M2
Bhargava, A2
Kakran, M2
Bhatnagar, R2
Mann, LM1
Kirkcaldy, RD4
Papp, JR3
Torrone, EA1
Lu, P1
Wang, S1
Lu, Y1
Neculai, D1
Sun, Q1
van der Veen, S1
Day, MJ1
Spiteri, G1
Amato-Gauci, AJ1
Sood, S1
Agarwal, SK1
Singh, R1
Gupta, S1
Sharma, VK1
Cole, M2
Dewsnap, C2
Harding, J3
Keogh, M1
Roberts, TE1
White, J2
Wilson, J2
Workowski, KA1
Ross, JD4
Meakin, G2
Roberts, T1
Oumeiri, BE1
Eynden, FV1
Stefanidis, C1
Antoine, M1
Nooten, GV1
Weinstock, HS1
Moore, PC1
Philip, SS1
Wiesenfeld, HC1
Kerndt, PR1
Johnson, S1
Ghanem, KG1
Hook, EW1
Hathorn, E1
Dhasmana, D1
Pettus, K1
Sharpe, S1
Joshi, NC1
Childs, M1
Brown, LB1
Kamanga, G2
Mapanje, C1
Kanyamula, H1
Banda, B1
Mhango, C2
Hoffman, M1
Kamwendo, D1
Hobbs, M2
Hosseinipour, MC1
Martinson, F1
Chisholm, SA1
Quaye, N1
Fredlund, H1
Hoffmann, S1
Jensen, JS1
van de Laar, MJ1
Ison, CA2
Brown, L1
Dowell, D1
Pereira, R1
Zabaneh, H1
Bacos, M1
Nassar, NT1
Alami, SY1
Kurban, AK1
Main, C1
Rajan, VS2
Szarmach, H1
Weuta, H1
Wroński, A1
Niezyporuk, W1
Podziewski, J1
Skarzyński, J1
Thompson, SE1
Hager, WD1
Wong, KH1
Lopez, B1
Ramsey, C1
Allen, SD1
Stargel, MD1
Thornsberry, C1
Benigno, BB1
Thompson, JD1
Shulman, JA1
Müller, G1
Tan, NJ1
Pang, R1
Sng, EH1
Risher, WH1
McFadden, PM1
Daly, CC1
Hoffman, I1
Maida, M1
Zimba, D1
Davis, R1
Mughogho, G1
Terho, P1
Iskandar, IO1
Naguib, F1
El Gabry, K1
Fanous, V1
Biehler, H1
Thelenberg, G1
Crössmann, W1
Danda, J1
Dbalý, V1
Hamáková, K1
Klíma, J1
Oriel, JD1
Reeve, P1
Thomas, BJ1
Nicol, CS2
Weeks, AG1
Entman, SS1
van Hall, MA1
Petit, PL1
van Hall, HN1
Mouton, RP1
Ndinya-Achola, JO1
Gunning, JE1
Bartunek, J1
Kraft, D1
Mayer-Hausner, E1
Lawrence, AG1
Phillips, I1
Reeves, DS2
Petzoldt, D1
Hantschke, D3
Strauss, P3
Linzenmeier, G1
Gahlen, D1
Heller, W2
Bowie, W1
Ronald, AR1
Krywulak, W1
Cates, CY1
Boutros, P1
McCracken, GH1
Eichenwald, HF1
Hatschke, D1
Jaeckel, A1
Ruedy, J1
Morrison, GD1
Holzmann, H1
Tupath-Barniske, R1
Morsches, B1
Meyer-Rohn, J1
Mauss, J1
Siboulet, A1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
New Antibiotic Treatment Options for Uncomplicated Anogenital Gonorrhoea Infections - a Double-blind Randomized Controlled Non-inferiority Trial[NCT03294395]Phase 3346 participants (Actual)Interventional2017-09-18Completed
Gentamicin for Pharyngeal Gonorrhea - A Demonstration Study[NCT03632109]Phase 2/Phase 313 participants (Actual)Interventional2018-09-17Terminated (stopped due to Efficacy)
Randomized Clinical Trial Evaluating the Efficacy of Gentamicin/Azithromycin and Gemifloxacin/Azithromycin Combination Therapies as an Alternative Regimen for Uncomplicated Urogenital Gonorrhea[NCT00926796]Phase 4614 participants (Actual)Interventional2010-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cure Rate Defined as the Percentage of Persons With Pharyngeal Gonorrhea Treated With Gentamicin 360mg IM Who Have a Negative Culture 4-7 Days Following Treatment

Negative Pharyngeal Culture (NCT03632109)
Timeframe: 4-7 days (+/- 1 day) after treatment

InterventionParticipants (Count of Participants)
Pharyngeal Gonorrhea2

Gentamicin Minimal Inhibitory Concentration (MIC)

laboratory defined MIC of infecting strain of N. gonorrhoeae at enrollment visit determined by agar dilution (NCT03632109)
Timeframe: baseline/enrollment visit

Interventionmicrogram/mL (Mean)
Single Arm6.9

Peak Gentamicin Levels

serum gentamicin concentration (NCT03632109)
Timeframe: at 30, 45, or 60 minutes post dose

Interventionmicrogram/mL (Mean)
Single Arm21.2

Renal Safety

Measured by a percent change in serum creatinine from baseline to test of cure (4-7 days following treatment) (NCT03632109)
Timeframe: 4-7 days (+/- 1 day) after treatment

Interventionpercent change (Mean)
Single Arm5.2

Tolerability of the Injection Gentamicin 360mg IM x 1

Participant reported pain scale, with 1 being little to no pain, and 10 being the worst pain ever. (NCT03632109)
Timeframe: 4-7 days (+/- 1 day) after treatment

Interventionscore on a scale (Mean)
Single Arm2

Eradication of Pharyngeal Infection

Number of enrollees with positive pharyngeal culture at enrollment who have negative culture 10-17 days after treatment (NCT00926796)
Timeframe: 10-17 days after treatment.

Interventionparticipants (Number)
Regimen A: Gentamicin Plus Azithromycin10
Regimen B: Gemifloxacin Plus Azithromycin15

Eradication of Rectal Infection

Number of enrollees with positive rectal culture at enrollment who have negative culture 10-17 days after treatment (NCT00926796)
Timeframe: 10-17 days after treatment.

Interventionparticipants (Number)
Regimen A: Gentamicin Plus Azithromycin1
Regimen B: Gemifloxacin Plus Azithromycin5

Microbiological Efficacy of Gemifloxacin and Azithromycin for the Treatment of Uncomplicated Gonococcal Infection

Percentage of enrollees negative by culture at cervix/urethra 10-17 days after treatment, regardless of history of re-exposure, among those with positive gonococcal cultures at enrollment (microbiological cure) (NCT00926796)
Timeframe: 10-17 days after treatment.

Interventionpercentage of participants (Number)
Regimen B: Gemifloxacin Plus Azithromycin99.50

Microbiological Efficacy of Gentamicin and Azithromycin for the Treatment of Uncomplicated Gonococcal Infection

Percentage of enrollees negative by culture at cervix/urethra 10-17 days after treatment, regardless of history of re-exposure, among those with positive gonococcal cultures at enrollment (microbiological cure) (NCT00926796)
Timeframe: 10-17 days after treatment.

Interventionpercentage of participants (Number)
Regimen A: Gentamicin Plus Azithromycin100

Number of Participants With Adverse Events for Each Regimen

Number of treated participants experiencing mild, moderate, severe, or life-threatening adverse events (AEs) either temporarily associated or not associated with study product. (NCT00926796)
Timeframe: Day 0 through Day 30

Interventionparticipants (Number)
Regimen A: Gentamicin Plus Azithromycin157
Regimen B: Gemifloxacin Plus Azithromycin185

Resolution of Symptoms and Signs (Clinical Cure)

Number of participants whose gonorrhea-related symptoms (e.g. vaginal/urethral discharge, dysuria, dyspareunia) present at enrollment has resolved by visit 2. (NCT00926796)
Timeframe: 10-17 days after treatment.

Interventionparticipants (Number)
Regimen A: Gentamicin Plus Azithromycin179
Regimen B: Gemifloxacin Plus Azithromycin177

Antimicrobial Susceptibility Profile of Enrollment Isolates.

Minimum inhibitory concentration (micrograms/milliliter) of pretreatment gonorrhea isolates collected from participants (NCT00926796)
Timeframe: Isolates obtained at enrollment (Day 0).

Interventionmicrograms/milliliter (Median)
AzithromycinCefiximeCeftriaxoneCiprofloxacinGemifloxacinGentamicinPenicillinTetracycline
Baseline0.250.0150.0080.0040.00440.50.5

Antimicrobial Susceptibility Profile of Treatment Failures.

For treatment failures (i.e., participants with positive culture at cervix/urethra 10-17 days after treatment), the minimum inhibitory concentrations for various antimicrobial agents (Azithromycin, Cefixime, Ceftriaxone, Ciprofloxacin, Gemifloxacin, Gentamicin, Penicillin, Tetracycline). (NCT00926796)
Timeframe: Isolates obtained at enrollment (Day 0).

Interventionmicrograms/milliliter (Median)
AzithromycinCefiximeCeftriaxoneCiprofloxacinGemifloxacinGentamicinPenicillinTetracycline
Regimen B: Gemifloxacin Plus Azithromycin0.250.0150.0040.0020.00440.50.25

Clinical Profile of Treatment Failures.

For treatment failures (i.e., participants with positive culture at cervix/urethra 10-17 days after treatment), number participants with clinical symptoms (vaginal/urethral discharge, dysuria, dyspareunia) at 10-17 days. (NCT00926796)
Timeframe: 10-17 days

Interventionparticipants (Number)
Vaginal/urethral dischargeDysuriaDyspareunia
Regimen B: Gemifloxacin Plus Azithromycin000

Reviews

8 reviews available for gentamicin and Gonorrhea

ArticleYear
Chlamydia and Gonorrhea.
    Annals of internal medicine, 2021, Volume: 174, Issue:10

    Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Chlamydia Infections; Doxycycline; Female; Gentami

2021
Economic evaluation of antimicrobial resistance in curable sexually transmitted infections; a systematic review and a case study.
    PloS one, 2023, Volume: 18, Issue:10

    Topics: Anti-Bacterial Agents; Ceftriaxone; Cost-Benefit Analysis; Drug Resistance, Bacterial; Gentamicins;

2023
The Use of Gentamicin for Treatment of Urogenital and Extragenital Gonorrhea: A Systematic Review of Efficacy Data.
    The Annals of pharmacotherapy, 2020, Volume: 54, Issue:10

    Topics: Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Bacterial; Drug Therapy, Combinati

2020
Safety of Single-Dose Oral Cefixime, Intramuscular Ceftriaxone, or Intramuscular Gentamicin for the Treatment of Gonorrhea: A Systematic Review and Meta-analysis.
    The Annals of pharmacotherapy, 2021, Volume: 55, Issue:7

    Topics: Anti-Bacterial Agents; Cefixime; Ceftriaxone; Gentamicins; Gonorrhea; Humans; Injections, Intramuscu

2021
The effectiveness of gentamicin in the treatment of Neisseria gonorrhoeae: a systematic review.
    Systematic reviews, 2014, Sep-19, Volume: 3

    Topics: Anti-Bacterial Agents; Gentamicins; Gonorrhea; Humans; Injections, Intramuscular; Neisseria gonorrho

2014
Effectiveness of gentamicin for gonorrhoea treatment: systematic review and meta-analysis.
    Sexually transmitted infections, 2012, Volume: 88, Issue:8

    Topics: Anti-Bacterial Agents; Gentamicins; Gonorrhea; Humans; Treatment Outcome; United States

2012
Antimicrobiol therapy: therapeutic recommendations and a review of newer drugs. Part I. Therapy of infectious conditions.
    The Journal of pediatrics, 1974, Volume: 85, Issue:3

    Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Arthritis, Infectious; Bacteroides Infections; Brain

1974
[Newer antibiotics].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1971, Volume: 22, Issue:2

    Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Antitubercular Agents; Cephal

1971

Trials

12 trials available for gentamicin and Gonorrhea

ArticleYear
Efficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial.
    The Lancet. Infectious diseases, 2022, Volume: 22, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Ertapenem; Fosfomycin; Gentamicins; Gonorrhea; Humans; Ne

2022
Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea: a randomized controlled trial.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020, Volume: 26, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Dos

2020
Gentamicin, azithromycin and ceftriaxone in the treatment of gonorrhoea: the relationship between antibiotic MIC and clinical outcome.
    The Journal of antimicrobial chemotherapy, 2020, 02-01, Volume: 75, Issue:2

    Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Drug Resistance, Bacterial; Gentamicins; Gonorrhea

2020
Spontaneous clearance of genital and extragenital
    Sexually transmitted infections, 2020, Volume: 96, Issue:8

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Female; Gent

2020
Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial.
    Lancet (London, England), 2019, 06-22, Volume: 393, Issue:10190

    Topics: Adolescent; Adult; Aged; Azithromycin; Ceftriaxone; Dose-Response Relationship, Drug; Drug Therapy,

2019
Gentamicin as an alternative to ceftriaxone in the treatment of gonorrhoea: the G-TOG non-inferiority RCT.
    Health technology assessment (Winchester, England), 2019, Volume: 23, Issue:20

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Ceftriaxone; Cost-Benefit Analysis; Drug Resistance,

2019
The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Oct-15, Volume: 59, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Azithromycin; Drug Therapy, Combinat

2014
Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial.
    Trials, 2016, 11-24, Volume: 17, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Cos

2016
The microbiology and therapy of acute pelvic inflammatory disease in hospitalized patients.
    American journal of obstetrics and gynecology, 1980, Jan-15, Volume: 136, Issue:2

    Topics: Adolescent; Adult; Amoxicillin; Anaerobiosis; Anti-Bacterial Agents; Bacteria; Drug Therapy, Combina

1980
[Gonorrhoea treated by gentamicin (author's treatment)].
    Ceskoslovenska dermatologie, 1976, Volume: 51, Issue:2

    Topics: Clinical Trials as Topic; Drug Evaluation; Gentamicins; Gonorrhea; Humans; Male

1976
A comparison of piperacillin and clindamycin plus gentamicin in women with pelvic infections.
    Surgery, gynecology & obstetrics, 1986, Volume: 163, Issue:2

    Topics: Abortion, Septic; Abscess; Adolescent; Adult; Bacterial Infections; Bacteroides Infections; Clindamy

1986
Treatment of gonorrhoea with single injections of gentamicin.
    The British journal of venereal diseases, 1973, Volume: 49, Issue:1

    Topics: Blood Urea Nitrogen; Clinical Trials as Topic; Creatinine; Epididymitis; Female; Gentamicins; Gonorr

1973

Other Studies

49 other studies available for gentamicin and Gonorrhea

ArticleYear
Gentamicin Susceptibility in Neisseria gonorrhoeae and Treatment Outcomes for Urogenital Gonorrhea After 25 Years of Sustained Gentamicin Use in Malawi.
    Sexually transmitted diseases, 2022, 04-01, Volume: 49, Issue:4

    Topics: Anti-Bacterial Agents; Azithromycin; Cefixime; Ceftriaxone; Ciprofloxacin; Female; Gentamicins; Gono

2022
A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in
    Antimicrobial agents and chemotherapy, 2022, 05-17, Volume: 66, Issue:5

    Topics: Amino Acid Substitution; Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Gentami

2022
Spectinomycin, gentamicin, and routine disc diffusion testing: An alternative for the treatment and monitoring of multidrug-resistant Neisseria gonorrhoeae?
    Journal of microbiological methods, 2022, Volume: 197

    Topics: Agar; Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Ciprofloxacin; Gentamicins; Gonorrhea; Human

2022
High-level in vitro resistance to gentamicin acquired in a stepwise manner in Neisseria gonorrhoeae.
    The Journal of antimicrobial chemotherapy, 2023, 07-05, Volume: 78, Issue:7

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Gentamicins; Gonorrhea; Humans; Microbial Sensiti

2023
Gentamicin Alone Is Inadequate to Eradicate Neisseria Gonorrhoeae From the Pharynx.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 11-05, Volume: 71, Issue:8

    Topics: Anti-Bacterial Agents; Azithromycin; Gentamicins; Gonorrhea; Homosexuality, Male; Humans; Male; Micr

2020
Re: 'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' by Rob et al.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020, Volume: 26, Issue:6

    Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Gentamicins; Gonorrhea; Humans; Neisseria gonorrho

2020
'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' - Author's reply.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020, Volume: 26, Issue:6

    Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Gentamicins; Gonorrhea; Humans; Neisseria gonorrho

2020
Is gentamicin a viable therapeutic option for treating resistant Neisseria gonorrhoeae in New South Wales?
    Communicable diseases intelligence (2018), 2021, Feb-26, Volume: 45

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Gentamicins; Gonorrhea; Humans; Male; Mic

2021
In vitro evaluation of antimicrobial resistance selection in Neisseria gonorrhoeae.
    International journal of antimicrobial agents, 2021, Volume: 58, Issue:4

    Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Ciprofloxacin; Doxycycline; Drug Resistance, Multi

2021
In Vitro Synergy Testing of Gentamicin, an Old Drug Suggested as Future Treatment Option for Gonorrhoea, in Combination With Six Other Antimicrobials Against Multidrug-Resistant Neisseria gonorrhoeae Strains.
    Sexually transmitted diseases, 2018, Volume: 45, Issue:2

    Topics: Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combinati

2018
Susceptibility of Neisseria gonorrhoeae to Gentamicin-Gonococcal Isolate Surveillance Project, 2015-2016.
    Sexually transmitted diseases, 2018, Volume: 45, Issue:2

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Epidemiological Monitoring; Gentamicins; Gonorrhe

2018
A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.
    The Journal of infectious diseases, 2019, 01-01, Volume: 219, Issue:1

    Topics: Autophagosomes; Autophagy; Epithelial Cells; Gentamicins; Gonorrhea; HeLa Cells; Host-Pathogen Inter

2019
Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016.
    BMC infectious diseases, 2018, Dec-03, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Azithromycin; Cefixime; Ceftriaxo

2018
In vitro assessment of gentamicin and azithromycin-based combination therapy against Neisseria gonorrhoeae isolates in India.
    Journal of medical microbiology, 2019, Volume: 68, Issue:4

    Topics: Anti-Bacterial Agents; Azithromycin; Disease Management; Drug Resistance, Multiple, Bacterial; Drug

2019
Gentamicin as an alternative treatment for gonorrhoea.
    Lancet (London, England), 2019, 06-22, Volume: 393, Issue:10190

    Topics: Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Gentamicins; Gonorrhea; Humans

2019
Gonococcal ascending aortic aneurysm with penetrating ulcer and bovine arch.
    Asian cardiovascular & thoracic annals, 2015, Volume: 23, Issue:7

    Topics: Administration, Intravenous; Aged; Aneurysm, Infected; Anti-Bacterial Agents; Aorta; Aorta, Thoracic

2015
In vitro assessment of dual drug combinations to inhibit growth of Neisseria gonorrhoeae.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:4

    Topics: Anti-Bacterial Agents; Azithromycin; Drug Combinations; Drug Interactions; Drug Resistance, Bacteria

2015
Gentamicin Susceptibility among a Sample of Multidrug-Resistant Neisseria gonorrhoeae Isolates in India.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:12

    Topics: Anti-Bacterial Agents; Cephalosporins; Drug Resistance, Multiple, Bacterial; Female; Gentamicins; Go

2016
Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007.
    Sexually transmitted diseases, 2010, Volume: 37, Issue:3

    Topics: Anti-Bacterial Agents; Doxycycline; Gentamicins; Gonorrhea; Humans; Malawi; Male; Microbial Sensitiv

2010
An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe.
    The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:3

    Topics: Adolescent; Anti-Bacterial Agents; European Union; Gentamicins; Gonorrhea; Humans; Microbial Sensiti

2011
Viewpoint: Gentamicin for treatment of gonococcal urethritis in Malawi.
    Malawi medical journal : the journal of Medical Association of Malawi, 2010, Volume: 22, Issue:3

    Topics: Anti-Bacterial Agents; Gentamicins; Gonorrhea; Humans; Malawi; Microbial Sensitivity Tests; Neisseri

2010
Cephalosporin resistant Neisseria gonorrhoeae: time to consider gentamicin?
    Sexually transmitted infections, 2012, Volume: 88, Issue:1

    Topics: Anti-Bacterial Agents; Cephalosporin Resistance; Drug Substitution; Gentamicins; Gonorrhea; Humans;

2012
Combination therapy for gonorrhoea: in vitro synergy testing.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:3

    Topics: Anti-Bacterial Agents; Azithromycin; Cefixime; Ceftriaxone; Drug Synergism; Gentamicins; Gonorrhea;

2013
Gonorrhea in the male: some aspects of treatment in Lebanon.
    Le Journal medical libanais. The Lebanese medical journal, 1980, Volume: 31, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents, Urinary;

1980
Treatment of septic arthritis.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007, Oct-09, Volume: 177, Issue:8

    Topics: Anti-Bacterial Agents; Arthritis, Infectious; Cefazolin; Cephalosporins; Gentamicins; Gonorrhea; Hum

2007
The treatment of gonorrhoea--beta lactamase producers.
    Annals of the Academy of Medicine, Singapore, 1983, Volume: 12, Issue:1

    Topics: 4-Quinolones; Anti-Bacterial Agents; Anti-Infective Agents; beta-Lactamases; Cephalosporins; Gentami

1983
[Sisomicin in the treatment of gonorrhea].
    Die Medizinische Welt, 1983, Jun-24, Volume: 34, Issue:25-26

    Topics: Adolescent; Adult; Drug Evaluation; Female; Gentamicins; Gonorrhea; Humans; Male; Microbial Sensitiv

1983
[In-vitro sensitivity of Neisseria gonorrhoeae against penicillin, ampicillin, oxytetracycline, streptomycin, gentamycin, and sulprim (author's transl)].
    Dermatologische Monatschrift, 1980, Volume: 166, Issue:1

    Topics: Ampicillin; Anti-Bacterial Agents; Female; Gentamicins; Gonorrhea; Humans; Male; Microbial Sensitivi

1980
Gentamicin in the treatment of infections due to penicillinase-producing gonococci.
    The British journal of venereal diseases, 1980, Volume: 56, Issue:6

    Topics: Female; Gentamicins; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Pe

1980
Neisseria gonorrhoeae mycotic ascending aortic aneurysm.
    The Annals of thoracic surgery, 1994, Volume: 57, Issue:3

    Topics: Adult; Aneurysm, Infected; Aortic Aneurysm; Ceftriaxone; Combined Modality Therapy; Drug Therapy, Co

1994
Development of an antimicrobial susceptibility surveillance system for Neisseria gonorrhoeae in Malawi: comparison of methods.
    Journal of clinical microbiology, 1997, Volume: 35, Issue:11

    Topics: Anti-Bacterial Agents; Gentamicins; Gonorrhea; Humans; Malawi; Microbial Sensitivity Tests; Neisseri

1997
Chlamydia trachomatis in gonococcal and postgonococcal urethritis.
    The British journal of venereal diseases, 1978, Volume: 54, Issue:5

    Topics: Adult; Chlamydia Infections; Chlamydia trachomatis; Gentamicins; Gonorrhea; Humans; Male; Penicillin

1978
A comparative study of gentamicin, co-trimoxazole and trimethoprim-sulphametrol in acute gonorrheal urethritis.
    The Journal of the Egyptian Medical Association, 1978, Volume: 61, Issue:7-8

    Topics: Drug Combinations; Gentamicins; Gonorrhea; Humans; Male; Sulfamethoxazole; Sulfanilamides; Trimethop

1978
[Double infection of ulcus molle and gonorrhea].
    Zeitschrift fur Hautkrankheiten, 1978, Jan-01, Volume: 53, Issue:1

    Topics: Adult; Chancroid; Gentamicins; Gonorrhea; Humans; Male; Streptomycin; Thailand; Travel

1978
Infection with Chlamydia group A in men with urethritis due to Neisseria gonorrhoeae.
    The Journal of infectious diseases, 1975, Volume: 131, Issue:4

    Topics: Antibodies; Chlamydia; Chlamydia Infections; Complement Fixation Tests; Culture Techniques; Fluoresc

1975
Gonococcal peritonitis after tubal ligation. A case report.
    The Journal of reproductive medicine, 1991, Volume: 36, Issue:9

    Topics: Adult; Ampicillin; Clindamycin; Diagnosis, Differential; Female; Gentamicins; Gonorrhea; Humans; Per

1991
Prevalence of resistance of N. gonorrhoeae to penicillin and three other antibiotics in a rural area in Kenya.
    East African medical journal, 1991, Volume: 68, Issue:11

    Topics: Drug Resistance, Microbial; Female; Gentamicins; Gonorrhea; Humans; Kenya; Male; Penicillin Resistan

1991
[Treatment of gonorrhea in women using a single gentamicin administration].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1974, Volume: 25, Issue:12

    Topics: Adolescent; Adult; Child; Cochlea; Drug Evaluation; Drug Tolerance; Female; Gentamicins; Gonorrhea;

1974
Gentamicin in sexually transmitted disease.
    Postgraduate medical journal, 1974, Volume: 50 Suppl 7

    Topics: Female; Gentamicins; Gonorrhea; Humans; Male; Urethritis

1974
Gonococcal urethritis treated with gentamicin.
    Postgraduate medical journal, 1974, Volume: 50 Suppl 7

    Topics: Female; Gentamicins; Gonorrhea; Humans; Male; Urethritis

1974
[One-time gentamicin therapy of gonorrhea. Its effect on Treponema pallidum].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1972, Volume: 23, Issue:9

    Topics: Animals; Gentamicins; Gonorrhea; Humans; Male; Orchitis; Rabbits; Treponema pallidum

1972
Gentamicin in the treatment of gonorrhoea in females.
    The British journal of venereal diseases, 1974, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Bacteriological Techniques; Cervix Uteri; Drug Resistance, Microbial; Female; Fol

1974
[Single Sulmycin (gentamycin)-treatment in gonorrhea].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:1

    Topics: Female; Gentamicins; Germany, West; Gonorrhea; Humans; Injections; Male; Retrospective Studies

1973
[Effect of short-term high gentamycin levels on inner ear function].
    HNO, 1973, Volume: 21, Issue:6

    Topics: Adult; Animals; Audiometry; Ear, Inner; Gentamicins; Gonorrhea; Guinea Pigs; Hearing Tests; Humans;

1973
Antibiotic treatment of septic arthritis.
    Clinical orthopaedics and related research, 1973, Issue:96

    Topics: Ampicillin; Anti-Bacterial Agents; Arthritis, Infectious; Cloxacillin; Gentamicins; Gonorrhea; Haemo

1973
Gentamicin in the treatment of gonococcal urethritis. A microbiological, pharmacological, and clinical study.
    The British journal of venereal diseases, 1973, Volume: 49, Issue:6

    Topics: Adolescent; Adult; Culture Media; Gentamicins; Gonorrhea; Humans; Injections, Intramuscular; Male; M

1973
[Effect of gentamicin on the motility of Treponema pallidum].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1969, Volume: 20, Issue:9

    Topics: Gentamicins; Gonorrhea; Humans; Penicillins; Syphilis; Treponema Immobilization Test; Treponema pall

1969
[Treatment of gonorrhea with sulmycin].
    Zeitschrift fur Haut- und Geschlechtskrankheiten, 1970, May-15, Volume: 45, Issue:10

    Topics: Adult; Female; Gentamicins; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin Resistance

1970
Results of the minute treatment of gonorrhoea in 26,339 cases.
    Postgraduate medical journal, 1972, Volume: 48

    Topics: Anti-Bacterial Agents; Erythromycin; Female; Gentamicins; Gonorrhea; Humans; Kanamycin; Leucomycins;

1972