gentamicin has been researched along with Glycosuria in 15 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF)." | 7.67 | Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. ( Alpert, HC; Gouvea, WL; Kelley, J; Pardo, V; Vaamonde, CA, 1989) |
| "Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF)." | 3.67 | Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. ( Alpert, HC; Gouvea, WL; Kelley, J; Pardo, V; Vaamonde, CA, 1989) |
| "Pony mares were randomly assigned to receive calcium at a dosage of 20 mg/kg of body weight or saline solution i." | 2.69 | Effect of intravenous calcium administration on gentamicin-induced nephrotoxicosis in ponies. ( Ames, TR; Brashier, MK; Geor, RJ; O'Leary, TP, 1998) |
| "No cases of Fanconi syndrome have been reported in clinical trials of TAF." | 1.56 | Renal proximal tubulopathy in an HIV-infected patient treated with tenofovir alafenamide and gentamicin: a case report. ( Bloch, M; Gracey, DM; Heron, JE; Saunders, J; Vanguru, V, 2020) |
| "Gentamicin induced increase in lipid peroxides, decrease in glutathione and activities of antioxidant enzymes in the kidney, and increase in blood creatinine, and urea concentrations were significantly countered by nigerloxin treatment." | 1.40 | Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats. ( Srinivasan, K; Suresha, BS, 2014) |
| " Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Differential toxicity synchronized with renal dysfunction process could be identified using 5/6 NX rats" was examined by dosing gentamicin." | 1.31 | Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach. ( Barata, K; Harada, E; Hokao, R; Imai, S; Maekawa, A; Takahashi, S; Yoshida, M, 2001) |
| " The measurement of gamma-glutamyl transpeptidase activity in urine can be applied as a useful parameter on determination of nephrotoxicity, especially for indicating the dimensions of this toxic effect." | 1.29 | Study on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicity. ( Başdemir, G; Berkan, T; Karan, A; Kocaoğlu, S, 1994) |
| " Both the rates of glucose formation from various substrates as well as pyruvate carboxylase and the cytosolic PEPCK activity recovered fully within 3 weeks after cessation of antibiotic treatment while an increase of activity of the mitochondrial PEPCK occurred during chronic administration of the drug for 10 days." | 1.28 | Recovery of impaired gluconeogenesis in kidney-cortex tubules of gentamicin-treated rabbits. ( Biedermann, I; Bryła, J; Lietz, T; Michalik, M, 1991) |
| "Nephrotoxicity of cefodizime sodium (THR-221), a new cephem antibiotic, was studied in rats by comparing its toxic effect with those of other cephem antibiotics including cephaloridine (CER), cefazolin (CEZ) and cefmetazol (CMZ)." | 1.27 | [Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. ( Hayashi, T; Irimura, K; Kuwata, M; Maruden, A; Morita, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Heron, JE | 1 |
| Bloch, M | 1 |
| Vanguru, V | 1 |
| Saunders, J | 1 |
| Gracey, DM | 1 |
| Suresha, BS | 1 |
| Srinivasan, K | 1 |
| Brinker, KR | 1 |
| Bulger, RE | 2 |
| Dobyan, DC | 1 |
| Stacey, TR | 1 |
| Southern, PM | 1 |
| Henrich, WL | 2 |
| Cronin, RE | 2 |
| Southern, P | 1 |
| Kocaoğlu, S | 1 |
| Berkan, T | 1 |
| Karan, A | 1 |
| Başdemir, G | 1 |
| Gouvea, W | 1 |
| Roth, D | 1 |
| Alpert, H | 1 |
| Kelley, J | 2 |
| Pardo, V | 2 |
| Vaamonde, CA | 2 |
| Davies, C | 1 |
| Forrester, SD | 1 |
| Troy, GC | 1 |
| Saunders, GK | 1 |
| Shell, LG | 1 |
| Johnston, SA | 1 |
| Brashier, MK | 1 |
| Geor, RJ | 1 |
| Ames, TR | 1 |
| O'Leary, TP | 1 |
| Barata, K | 1 |
| Yoshida, M | 1 |
| Hokao, R | 1 |
| Imai, S | 1 |
| Takahashi, S | 1 |
| Harada, E | 1 |
| Maekawa, A | 1 |
| Miller, GH | 1 |
| Chiu, PJ | 1 |
| Waitz, JA | 1 |
| Thomsen, HS | 1 |
| Skaarup, P | 1 |
| Larsen, S | 1 |
| Golman, K | 1 |
| Hemmingsen, L | 1 |
| Michalik, M | 1 |
| Biedermann, I | 1 |
| Lietz, T | 1 |
| Bryła, J | 1 |
| Garry, F | 1 |
| Chew, DJ | 1 |
| Hoffsis, GF | 1 |
| Gouvea, WL | 1 |
| Alpert, HC | 1 |
| Hayashi, T | 1 |
| Maruden, A | 1 |
| Irimura, K | 1 |
| Kuwata, M | 1 |
| Morita, K | 1 |
2 trials available for gentamicin and Glycosuria
| Article | Year |
|---|---|
Effects of a prostaglandin E1 analogue, misoprostol, on renal function in dogs receiving nephrotoxic doses of gentamicin.
Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Creatinine; Dogs; Electrolytes; Gentamicins; Gl | 1998 |
Effect of intravenous calcium administration on gentamicin-induced nephrotoxicosis in ponies.
Topics: Animals; Anti-Bacterial Agents; Blood Glucose; Blood Urea Nitrogen; Calcium; Calcium Gluconate; Crea | 1998 |
13 other studies available for gentamicin and Glycosuria
| Article | Year |
|---|---|
Renal proximal tubulopathy in an HIV-infected patient treated with tenofovir alafenamide and gentamicin: a case report.
Topics: Acute Disease; Alanine; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Antiv | 2020 |
Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.
Topics: Aldehyde Reductase; Animals; Anti-Bacterial Agents; Aspergillus niger; Benzoates; Blood Glucose; Cre | 2014 |
Effect of potassium depletion on gentamicin nephrotoxicity.
Topics: Animals; Calcium; Creatinine; Dogs; Gentamicins; Glycosuria; Kidney; Magnesium; Phosphorus; Potassiu | 1981 |
Natural history of aminoglycoside nephrotoxicity in the dog.
Topics: Animals; Dogs; Electrolytes; Gentamicins; Glomerular Filtration Rate; Glucose; Glycosuria; Kidney Tu | 1980 |
Study on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicity.
Topics: Animals; Anti-Bacterial Agents; Blood Glucose; gamma-Glutamyltransferase; Gentamicins; Glycosuria; K | 1994 |
Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat.
Topics: Animals; Body Weight; Creatine; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Hy | 1994 |
Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach.
Topics: Albumins; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Blood Proteins; Creatinine; Disease M | 2001 |
Biological activity of SCH 21420, the 1-N-S-alpha-hydroxy-beta-aminopropionyl derivative of gentamicin B.
Topics: Animals; Bacteria; Blood Pressure; Dogs; Gentamicins; Glomerular Filtration Rate; Glycosuria; Half-L | 1978 |
Gentamicin nephropathy and contrast media. A comparison between diatrizoate and iohexol in rats.
Topics: Acetylglucosaminidase; Albuminuria; Animals; Diatrizoate; gamma-Glutamyltransferase; Gentamicins; Gl | 1990 |
Recovery of impaired gluconeogenesis in kidney-cortex tubules of gentamicin-treated rabbits.
Topics: Animals; Blood Glucose; Creatinine; Cytosol; Gentamicins; Gluconeogenesis; Glycosuria; In Vitro Tech | 1991 |
Urinary indices of renal function in sheep with induced aminoglycoside nephrotoxicosis.
Topics: Acute Kidney Injury; Animals; Blood Glucose; Electrolytes; Female; Gentamicins; Glycosuria; Hyperpla | 1990 |
Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Kidn | 1989 |
[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
Topics: Animals; Cefazolin; Cefmetazole; Cefotaxime; Cephaloridine; Drug Administration Schedule; Drug Thera | 1988 |