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gentamicin and Glycosuria

gentamicin has been researched along with Glycosuria in 15 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).

Research Excerpts

ExcerptRelevanceReference
"Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF)."7.67Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. ( Alpert, HC; Gouvea, WL; Kelley, J; Pardo, V; Vaamonde, CA, 1989)
"Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF)."3.67Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. ( Alpert, HC; Gouvea, WL; Kelley, J; Pardo, V; Vaamonde, CA, 1989)
"Pony mares were randomly assigned to receive calcium at a dosage of 20 mg/kg of body weight or saline solution i."2.69Effect of intravenous calcium administration on gentamicin-induced nephrotoxicosis in ponies. ( Ames, TR; Brashier, MK; Geor, RJ; O'Leary, TP, 1998)
"No cases of Fanconi syndrome have been reported in clinical trials of TAF."1.56Renal proximal tubulopathy in an HIV-infected patient treated with tenofovir alafenamide and gentamicin: a case report. ( Bloch, M; Gracey, DM; Heron, JE; Saunders, J; Vanguru, V, 2020)
"Gentamicin induced increase in lipid peroxides, decrease in glutathione and activities of antioxidant enzymes in the kidney, and increase in blood creatinine, and urea concentrations were significantly countered by nigerloxin treatment."1.40Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats. ( Srinivasan, K; Suresha, BS, 2014)
" Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Differential toxicity synchronized with renal dysfunction process could be identified using 5/6 NX rats" was examined by dosing gentamicin."1.31Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach. ( Barata, K; Harada, E; Hokao, R; Imai, S; Maekawa, A; Takahashi, S; Yoshida, M, 2001)
" The measurement of gamma-glutamyl transpeptidase activity in urine can be applied as a useful parameter on determination of nephrotoxicity, especially for indicating the dimensions of this toxic effect."1.29Study on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicity. ( Başdemir, G; Berkan, T; Karan, A; Kocaoğlu, S, 1994)
" Both the rates of glucose formation from various substrates as well as pyruvate carboxylase and the cytosolic PEPCK activity recovered fully within 3 weeks after cessation of antibiotic treatment while an increase of activity of the mitochondrial PEPCK occurred during chronic administration of the drug for 10 days."1.28Recovery of impaired gluconeogenesis in kidney-cortex tubules of gentamicin-treated rabbits. ( Biedermann, I; Bryła, J; Lietz, T; Michalik, M, 1991)
"Nephrotoxicity of cefodizime sodium (THR-221), a new cephem antibiotic, was studied in rats by comparing its toxic effect with those of other cephem antibiotics including cephaloridine (CER), cefazolin (CEZ) and cefmetazol (CMZ)."1.27[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. ( Hayashi, T; Irimura, K; Kuwata, M; Maruden, A; Morita, K, 1988)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19905 (33.33)18.7374
1990's7 (46.67)18.2507
2000's1 (6.67)29.6817
2010's1 (6.67)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Heron, JE1
Bloch, M1
Vanguru, V1
Saunders, J1
Gracey, DM1
Suresha, BS1
Srinivasan, K1
Brinker, KR1
Bulger, RE2
Dobyan, DC1
Stacey, TR1
Southern, PM1
Henrich, WL2
Cronin, RE2
Southern, P1
Kocaoğlu, S1
Berkan, T1
Karan, A1
Başdemir, G1
Gouvea, W1
Roth, D1
Alpert, H1
Kelley, J2
Pardo, V2
Vaamonde, CA2
Davies, C1
Forrester, SD1
Troy, GC1
Saunders, GK1
Shell, LG1
Johnston, SA1
Brashier, MK1
Geor, RJ1
Ames, TR1
O'Leary, TP1
Barata, K1
Yoshida, M1
Hokao, R1
Imai, S1
Takahashi, S1
Harada, E1
Maekawa, A1
Miller, GH1
Chiu, PJ1
Waitz, JA1
Thomsen, HS1
Skaarup, P1
Larsen, S1
Golman, K1
Hemmingsen, L1
Michalik, M1
Biedermann, I1
Lietz, T1
Bryła, J1
Garry, F1
Chew, DJ1
Hoffsis, GF1
Gouvea, WL1
Alpert, HC1
Hayashi, T1
Maruden, A1
Irimura, K1
Kuwata, M1
Morita, K1

Trials

2 trials available for gentamicin and Glycosuria

ArticleYear
Effects of a prostaglandin E1 analogue, misoprostol, on renal function in dogs receiving nephrotoxic doses of gentamicin.
    American journal of veterinary research, 1998, Volume: 59, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Creatinine; Dogs; Electrolytes; Gentamicins; Gl

1998
Effect of intravenous calcium administration on gentamicin-induced nephrotoxicosis in ponies.
    American journal of veterinary research, 1998, Volume: 59, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Blood Glucose; Blood Urea Nitrogen; Calcium; Calcium Gluconate; Crea

1998

Other Studies

13 other studies available for gentamicin and Glycosuria

ArticleYear
Renal proximal tubulopathy in an HIV-infected patient treated with tenofovir alafenamide and gentamicin: a case report.
    BMC nephrology, 2020, 08-12, Volume: 21, Issue:1

    Topics: Acute Disease; Alanine; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Antiv

2020
Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:9

    Topics: Aldehyde Reductase; Animals; Anti-Bacterial Agents; Aspergillus niger; Benzoates; Blood Glucose; Cre

2014
Effect of potassium depletion on gentamicin nephrotoxicity.
    The Journal of laboratory and clinical medicine, 1981, Volume: 98, Issue:2

    Topics: Animals; Calcium; Creatinine; Dogs; Gentamicins; Glycosuria; Kidney; Magnesium; Phosphorus; Potassiu

1981
Natural history of aminoglycoside nephrotoxicity in the dog.
    The Journal of laboratory and clinical medicine, 1980, Volume: 95, Issue:3

    Topics: Animals; Dogs; Electrolytes; Gentamicins; Glomerular Filtration Rate; Glucose; Glycosuria; Kidney Tu

1980
Study on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicity.
    Archivum immunologiae et therapiae experimentalis, 1994, Volume: 42, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Blood Glucose; gamma-Glutamyltransferase; Gentamicins; Glycosuria; K

1994
Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1994, Volume: 206, Issue:4

    Topics: Animals; Body Weight; Creatine; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Hy

1994
Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach.
    Human & experimental toxicology, 2001, Volume: 20, Issue:2

    Topics: Albumins; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Blood Proteins; Creatinine; Disease M

2001
Biological activity of SCH 21420, the 1-N-S-alpha-hydroxy-beta-aminopropionyl derivative of gentamicin B.
    The Journal of antibiotics, 1978, Volume: 31, Issue:7

    Topics: Animals; Bacteria; Blood Pressure; Dogs; Gentamicins; Glomerular Filtration Rate; Glycosuria; Half-L

1978
Gentamicin nephropathy and contrast media. A comparison between diatrizoate and iohexol in rats.
    Acta radiologica (Stockholm, Sweden : 1987), 1990, Volume: 31, Issue:4

    Topics: Acetylglucosaminidase; Albuminuria; Animals; Diatrizoate; gamma-Glutamyltransferase; Gentamicins; Gl

1990
Recovery of impaired gluconeogenesis in kidney-cortex tubules of gentamicin-treated rabbits.
    Pharmacological research, 1991, Volume: 23, Issue:3

    Topics: Animals; Blood Glucose; Creatinine; Cytosol; Gentamicins; Gluconeogenesis; Glycosuria; In Vitro Tech

1991
Urinary indices of renal function in sheep with induced aminoglycoside nephrotoxicosis.
    American journal of veterinary research, 1990, Volume: 51, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Glucose; Electrolytes; Female; Gentamicins; Glycosuria; Hyperpla

1990
Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.
    Kidney international, 1989, Volume: 35, Issue:4

    Topics: Acute Kidney Injury; Animals; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Kidn

1989
[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
    The Journal of toxicological sciences, 1988, Volume: 13 Suppl 1

    Topics: Animals; Cefazolin; Cefmetazole; Cefotaxime; Cephaloridine; Drug Administration Schedule; Drug Thera

1988