gentamicin has been researched along with Genetic Diseases, Inborn in 5 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Genetic Diseases, Inborn: Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The known oto- and nephrotoxicity associated with aminoglycosides preclude long-term use as readthrough agents." | 1.48 | The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential. ( Babu, S; Baiazitov, R; Branstrom, A; Colacino, JM; Elfring, G; Friesen, WJ; Hedrick, J; Johnson, B; Mollin, A; Moon, YC; Morrill, C; Peltz, SW; Ren, H; Sheedy, J; Sierra, J; Tomizawa, Y; Vazirani, P; Weetall, M; Welch, EM; Xue, X; Zhuo, J, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bidou, L | 1 |
| Bugaud, O | 1 |
| Merer, G | 1 |
| Coupet, M | 1 |
| Hatin, I | 1 |
| Chirkin, E | 1 |
| Karri, S | 1 |
| Demais, S | 1 |
| François, P | 1 |
| Cintrat, JC | 1 |
| Namy, O | 1 |
| Friesen, WJ | 1 |
| Johnson, B | 1 |
| Sierra, J | 1 |
| Zhuo, J | 1 |
| Vazirani, P | 1 |
| Xue, X | 1 |
| Tomizawa, Y | 1 |
| Baiazitov, R | 1 |
| Morrill, C | 1 |
| Ren, H | 1 |
| Babu, S | 1 |
| Moon, YC | 1 |
| Branstrom, A | 1 |
| Mollin, A | 1 |
| Hedrick, J | 1 |
| Sheedy, J | 1 |
| Elfring, G | 1 |
| Weetall, M | 1 |
| Colacino, JM | 1 |
| Welch, EM | 1 |
| Peltz, SW | 1 |
| Shiozuka, M | 1 |
| Wagatsuma, A | 1 |
| Kawamoto, T | 1 |
| Sasaki, H | 1 |
| Shimada, K | 1 |
| Takahashi, Y | 1 |
| Nonomura, Y | 1 |
| Matsuda, R | 1 |
| Nudelman, I | 1 |
| Glikin, D | 1 |
| Smolkin, B | 1 |
| Hainrichson, M | 1 |
| Belakhov, V | 1 |
| Baasov, T | 1 |
| Kaufman, RJ | 1 |
1 review available for gentamicin and Genetic Diseases, Inborn
| Article | Year |
|---|---|
Correction of genetic disease by making sense from nonsense.
Topics: Animals; Codon, Nonsense; Dystrophin; Genetic Diseases, Inborn; Genetic Therapy; Gentamicins; Humans | 1999 |
4 other studies available for gentamicin and Genetic Diseases, Inborn
| Article | Year |
|---|---|
2-Guanidino-quinazoline promotes the readthrough of nonsense mutations underlying human genetic diseases.
Topics: Cell Line; Codon, Nonsense; Codon, Terminator; Drug Evaluation, Preclinical; Genes, Reporter; Geneti | 2022 |
The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.
Topics: Aminoglycosides; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Codon, Nonsense; Codon, Term | 2018 |
Transdermal delivery of a readthrough-inducing drug: a new approach of gentamicin administration for the treatment of nonsense mutation-mediated disorders.
Topics: Administration, Cutaneous; Animals; Basement Membrane; Codon, Nonsense; Dystrophin; Epidermis; Extra | 2010 |
Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations.
Topics: Aminoglycosides; Animals; Codon, Nonsense; Cystic Fibrosis; Drug Design; Genetic Diseases, Inborn; G | 2010 |