gentamicin has been researched along with Frontotemporal Lobar Degeneration in 1 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Frontotemporal Lobar Degeneration: Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia." | 1.56 | Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. ( Arns, S; Balgi, AD; Baradaran-Heravi, A; Feldman, HH; Frew, J; Gao, FB; Jansen-West, KR; Jaquith, JB; Lynn, FC; Mackenzie, IR; Nygaard, HB; Petrucelli, L; Roberge, M; Shidmoossavee, FS; Tan, J; Wu, X; Yan, TD, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frew, J | 1 |
| Baradaran-Heravi, A | 1 |
| Balgi, AD | 1 |
| Wu, X | 1 |
| Yan, TD | 1 |
| Arns, S | 1 |
| Shidmoossavee, FS | 1 |
| Tan, J | 1 |
| Jaquith, JB | 1 |
| Jansen-West, KR | 1 |
| Lynn, FC | 1 |
| Gao, FB | 1 |
| Petrucelli, L | 1 |
| Feldman, HH | 1 |
| Mackenzie, IR | 1 |
| Roberge, M | 1 |
| Nygaard, HB | 1 |
1 other study available for gentamicin and Frontotemporal Lobar Degeneration
| Article | Year |
|---|---|
Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency.
Topics: Animals; Cells, Cultured; Codon, Nonsense; Codon, Terminator; Frontotemporal Lobar Degeneration; Gen | 2020 |