gentamicin has been researched along with Fractures, Compound in 38 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gentamicin was not associated with AKI (odds ratio [OR] 0." | 5.43 | Prophylactic Gentamicin Is Not Associated with Acute Kidney Injury in Patients with Open Fractures. ( Duane, TM; Gandhi, RR; Moore, B; Putty, B; Tessier, JM, 2016) |
| " This study investigates the use of such scaffolds with gentamicin (along with bone morphogenetic protein) in an infected rat open fracture model to decrease osteomyelitis and promote fracture healing." | 3.76 | The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model. ( Chu, TM; Cox, JT; Duffy, L; Stannard, J; Stewart, RL; Volgas, D; Waites, KB, 2010) |
| " Thus, daily dosing of gentamicin was found to be safe, effective, and cost efficient in the treatment of open fractures when combined with a cephalosporin and aggressive operative debridement and stabilization." | 2.69 | Once daily, high dose versus divided, low dose gentamicin for open fractures. ( Bjornson, SH; Cockrin, J; Kirk, PG; Levy, MS; Ruhnke, CJ; Sorger, JI; Tang, P, 1999) |
| "To compare the first-dose pharmacokinetic parameters of gentamicin 6 mg/kg and 2 mg/kg in stable, nonobese surgical intensive care unit patients with open extremity fractures receiving gentamicin prophylactically." | 2.68 | Pharmacokinetics of once-daily dosing of gentamicin in surgical intensive care unit patients with open fractures. ( Bjornson, HS; Healy, DP; Miyagawa, CI; Sangha, KS, 1995) |
| "Open fractures are at significant risk of developing a fracture-related infection, despite the routine administration of perioperative antibiotic prophylaxis." | 1.56 | Local Application of a Gentamicin-Loaded Hydrogel Early After Injury Is Superior to Perioperative Systemic Prophylaxis in a Rabbit Open Fracture Model. ( Arens, D; D'Este, M; Deimling, C; Eglin, D; Metsemakers, WJ; Morgenstern, M; Moriarty, TF; Puetzler, J; Richards, RG; Vallejo Diaz, A; Zeiter, S, 2020) |
| " This is due to the fact that cefazolin is stocked in the hospital ER, while gentamicin is commonly not due to weight-based dosing requirements precluding a standard dose." | 1.48 | Administration of intravenous antibiotics in patients with open fractures is dependent on emergency room triaging. ( Eccles, J; Harper, KD; Quinn, C; Ramsey, F; Rehman, S, 2018) |
| "Antibiotic administration during the treatment of open fractures has been shown to reduce infection rates and is considered a critical step in the management of these injuries." | 1.43 | Antibiotic related acute kidney injury in patients treated for open fractures. ( Banks, K; Hahn, J; Inaba, K; Marecek, GS; Pannell, WC, 2016) |
| "Gentamicin was not associated with AKI (odds ratio [OR] 0." | 1.43 | Prophylactic Gentamicin Is Not Associated with Acute Kidney Injury in Patients with Open Fractures. ( Duane, TM; Gandhi, RR; Moore, B; Putty, B; Tessier, JM, 2016) |
| "Sixteen patients were identified in whom once daily gentamicin dosing was used as part of an antibiotic prophylaxis regimen in patients with types II and III open tibial shaft fractures." | 1.31 | Once daily high-dose gentamicin to prevent infection in open fractures of the tibial shaft: a preliminary investigation. ( King, C; May, CG; Pearsall, AW; Russell, GV, 2001) |
| "The most serious complications in the treatment of open fractures and after procedures on bone tissue are infections." | 1.28 | [Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma]. ( Kateusz, J; Misterka, S, 1992) |
| "In the treatment of osteomyelitis, flap coverage provides the necessary blood supply for healing." | 1.27 | [Skin-soft tissue replacement on the lower leg--therapy and prophylaxis of osteomyelitis]. ( Scharnagl, E, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (10.53) | 18.7374 |
| 1990's | 10 (26.32) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 16 (42.11) | 24.3611 |
| 2020's | 5 (13.16) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, KH | 1 |
| Galanis, A | 1 |
| Balasubramanian, P | 1 |
| Iliadis, AD | 1 |
| Heidari, N | 1 |
| Vris, A | 1 |
| Rohilla, R | 1 |
| Arora, S | 1 |
| Kundu, A | 1 |
| Singh, R | 1 |
| Govil, V | 1 |
| Khokhar, A | 1 |
| Pinto, D | 1 |
| Manjunatha, K | 1 |
| Savur, AD | 1 |
| Ahmed, NR | 1 |
| Mallya, S | 1 |
| Ramya, V | 1 |
| Vicenti, G | 1 |
| Bizzoca, D | 1 |
| Cotugno, D | 1 |
| Carrozzo, M | 1 |
| Riefoli, F | 1 |
| Rifino, F | 1 |
| Belviso, V | 1 |
| Elia, R | 1 |
| Solarino, G | 1 |
| Moretti, B | 1 |
| Vallejo Diaz, A | 1 |
| Deimling, C | 1 |
| Morgenstern, M | 1 |
| D'Este, M | 1 |
| Puetzler, J | 1 |
| Zeiter, S | 1 |
| Arens, D | 1 |
| Metsemakers, WJ | 2 |
| Richards, RG | 1 |
| Eglin, D | 1 |
| Moriarty, TF | 1 |
| Walter, N | 1 |
| Popp, D | 1 |
| Freigang, V | 1 |
| Nerlich, M | 1 |
| Alt, V | 1 |
| Rupp, M | 1 |
| Folse, J | 1 |
| Hill, CE | 1 |
| Graves, ML | 1 |
| Russell, GV | 2 |
| Hydrick, J | 1 |
| Jones, LC | 1 |
| Replogle, WH | 1 |
| Bergin, PF | 1 |
| Spitler, CA | 1 |
| Harper, KD | 1 |
| Quinn, C | 1 |
| Eccles, J | 1 |
| Ramsey, F | 1 |
| Rehman, S | 1 |
| Ng, T | 1 |
| Unadkat, J | 1 |
| Bilonick, RA | 1 |
| Wollstein, R | 1 |
| Penn-Barwell, JG | 1 |
| Murray, CK | 1 |
| Wenke, JC | 1 |
| Seligson, D | 1 |
| Berling, S | 1 |
| Reul, M | 1 |
| Nijs, S | 1 |
| Lawing, CR | 1 |
| Lin, FC | 1 |
| Dahners, LE | 1 |
| Redfern, J | 1 |
| Wasilko, SM | 1 |
| Groth, ME | 1 |
| McMillian, WD | 1 |
| Bartlett, CS | 1 |
| Pannell, WC | 1 |
| Banks, K | 1 |
| Hahn, J | 1 |
| Inaba, K | 1 |
| Marecek, GS | 1 |
| Noor, S | 1 |
| Gilson, A | 1 |
| Kennedy, K | 1 |
| Swanson, A | 1 |
| Vanny, V | 1 |
| Mony, K | 1 |
| Chaudhry, T | 1 |
| Gollogly, J | 1 |
| Möllering, N | 1 |
| Lenhartz, H | 1 |
| Stegmann, J | 1 |
| Höger, P | 1 |
| Tessier, JM | 1 |
| Moore, B | 1 |
| Putty, B | 1 |
| Gandhi, RR | 1 |
| Duane, TM | 1 |
| Borade, A | 1 |
| Kempegowda, H | 1 |
| Fernandez, M | 1 |
| Horwitz, DS | 1 |
| Stewart, RL | 1 |
| Cox, JT | 1 |
| Volgas, D | 1 |
| Stannard, J | 1 |
| Duffy, L | 1 |
| Waites, KB | 1 |
| Chu, TM | 1 |
| Chaudhary, S | 1 |
| Sen, RK | 1 |
| Saini, UC | 1 |
| Soni, A | 1 |
| Gahlot, N | 1 |
| Singh, D | 1 |
| Kumar, P | 1 |
| Shrestha, D | 1 |
| Bajracharya, S | 1 |
| Plese, JP | 1 |
| Humphreys, RP | 1 |
| Jerosch, J | 1 |
| Lindner, N | 1 |
| Fuchs, S | 1 |
| Liu, G | 1 |
| Du, J | 1 |
| Sangha, KS | 1 |
| Miyagawa, CI | 1 |
| Healy, DP | 1 |
| Bjornson, HS | 1 |
| Calhoun, JH | 1 |
| Anger, DM | 1 |
| Ledbetter, BR | 1 |
| Cobos, JA | 1 |
| Mader, JT | 1 |
| Holcombe, SJ | 1 |
| Schneider, RK | 1 |
| Bramlage, LR | 1 |
| Embertson, RM | 1 |
| Sorger, JI | 1 |
| Kirk, PG | 1 |
| Ruhnke, CJ | 1 |
| Bjornson, SH | 1 |
| Levy, MS | 1 |
| Cockrin, J | 1 |
| Tang, P | 1 |
| King, C | 1 |
| May, CG | 1 |
| Pearsall, AW | 1 |
| Ohtsuka, H | 1 |
| Yokoyama, K | 1 |
| Higashi, K | 1 |
| Tsutsumi, A | 1 |
| Fukushima, N | 1 |
| Noumi, T | 1 |
| Itoman, M | 1 |
| Vécsei, V | 1 |
| Dingeldein, E | 1 |
| Klemm, K | 2 |
| Wahlig, H | 1 |
| Misterka, S | 1 |
| Kateusz, J | 1 |
| Walz, M | 1 |
| Ascherl, R | 1 |
| Stemberg, A | 1 |
| Lechner, F | 1 |
| Blümel, G | 1 |
| Scharnagl, E | 1 |
| Schein, CS | 1 |
| Black, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial[NCT05421741] | Phase 4 | 484 participants (Anticipated) | Interventional | 2023-05-15 | Recruiting | ||
| Results of the Staged Surgical Approach for Management of Infected Un-united Femoral Shaft Fractures in Adults[NCT04681846] | 40 participants (Anticipated) | Observational | 2021-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for gentamicin and Fractures, Compound
| Article | Year |
|---|---|
Antibiotic-laden PMMA bead chains for the prevention of infection in compound fractures: current state of the art.
Topics: Administration, Topical; Anti-Bacterial Agents; Fractures, Open; Gentamicins; Humans; Methylmethacry | 2015 |
The use of gentamicin-coated nails in complex open tibia fracture and revision cases: A retrospective analysis of a single centre case series and review of the literature.
Topics: Adult; Aged; Anti-Bacterial Agents; Belgium; Bone Nails; Female; Fracture Fixation, Intramedullary; | 2015 |
Osteoarticular allograft reconstruction of post-traumatic defect of distal femur in a pediatric patient: A case report and literature review.
Topics: Allografts; Anti-Bacterial Agents; Bone Transplantation; Cartilage; Child, Preschool; Debridement; D | 2016 |
4 trials available for gentamicin and Fractures, Compound
| Article | Year |
|---|---|
Functional and radiological outcomes of primary ring fixator versus antibiotic nail in open tibial diaphyseal fractures: A prospective study.
Topics: Anti-Bacterial Agents; Bone Nails; Diaphyses; Fracture Fixation, Intramedullary; Fracture Healing; F | 2022 |
Pharmacokinetics of once-daily dosing of gentamicin in surgical intensive care unit patients with open fractures.
Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Female; Fractures, Open; Gentamicins; Hospita | 1995 |
The Ilizarov fixator and polymethylmethacrylate-antibiotic beads for the treatment of infected deformities.
Topics: Adult; Chronic Disease; Combined Modality Therapy; Debridement; Drug Therapy, Combination; External | 1993 |
Once daily, high dose versus divided, low dose gentamicin for open fractures.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Cefazolin; Cephalosporins; Debridement; Drug Adminis | 1999 |
31 other studies available for gentamicin and Fractures, Compound
| Article | Year |
|---|---|
A major trauma centre experience with gentamicin-coated tibial intramedullary nails (ETN PROtect™) in acute primary open fracture fixation and complex revision surgery.
Topics: Adult; Bone Nails; Fracture Fixation, Intramedullary; Fracture Healing; Fractures, Open; Gentamicins | 2023 |
Comparative study of the efficacy of gentamicin-coated intramedullary interlocking nail versus regular intramedullary interlocking nail in Gustilo type I and II open tibia fractures.
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bone Nails; Follow-Up Studies; Fracture Fixati | 2019 |
The use of a gentamicin-coated titanium nail, combined with RIA system, in the management of non-unions of open tibial fractures: A single centre prospective study.
Topics: Adult; Bone Nails; Female; Follow-Up Studies; Fracture Fixation, Intramedullary; Fracture Healing; F | 2020 |
Local Application of a Gentamicin-Loaded Hydrogel Early After Injury Is Superior to Perioperative Systemic Prophylaxis in a Rabbit Open Fracture Model.
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefuroxime; Fractures, Open; Gentamicins; Hy | 2020 |
Treatment of severely open tibial fractures, non-unions, and fracture-related infections with a gentamicin-coated tibial nail-clinical outcomes including quality of life analysis and psychological ICD-10-based symptom rating.
Topics: Adult; Aged; Anti-Bacterial Agents; Bone Nails; Device Removal; Female; Fracture Fixation, Intramedu | 2021 |
Risk Factors for Kidney Dysfunction With the Use of Gentamicin in Open Fracture Antibiotic Treatment.
Topics: Acute Kidney Injury; Antibiotic Prophylaxis; Case-Control Studies; Databases, Factual; Female; Fract | 2018 |
Administration of intravenous antibiotics in patients with open fractures is dependent on emergency room triaging.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Emergency Servic | 2018 |
The importance of early operative treatment in open fractures of the fingers.
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Clindamycin; Debridement; Female; Finger Injur | 2014 |
Local antibiotic delivery by a bioabsorbable gel is superior to PMMA bead depot in reducing infection in an open fracture model.
Topics: Absorbable Implants; Administration, Topical; Animals; Anti-Bacterial Agents; Disease Models, Animal | 2014 |
Local Injection of Aminoglycosides for Prophylaxis Against Infection in Open Fractures.
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Female; Follow-Up Studies; Fracture Fixation; | 2015 |
Surgical Site Infections in Patients With Type 3 Open Fractures: Comparing Antibiotic Prophylaxis With Cefazolin Plus Gentamicin Versus Piperacillin/Tazobactam.
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Cohort Studies; Drug Combinations; | 2016 |
Antibiotic related acute kidney injury in patients treated for open fractures.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cefazolin; F | 2016 |
Pre-packing of cost effective antibiotic cement beads for the treatment of traumatic osteomyelitis in the developing world - an in-vitro study based in Cambodia.
Topics: Amikacin; Anti-Bacterial Agents; Bone Cements; Cambodia; Ceftriaxone; Cost-Benefit Analysis; Delayed | 2016 |
[Imported Bacteremia].
Topics: Administration, Oral; Arteries; Arthralgia; Bacteremia; Brucella melitensis; Brucellosis; Child; Dia | 2016 |
Prophylactic Gentamicin Is Not Associated with Acute Kidney Injury in Patients with Open Fractures.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Female; Fractures, Open; | 2016 |
The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model.
Topics: Absorbable Implants; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Carriers; Femoral | 2010 |
Use of gentamicin-loaded collagen sponge in internal fixation of open fractures.
Topics: Animals; Collagen; Fracture Fixation, Internal; Fractures, Open; Gentamicins; Humans; Porifera; Tibi | 2011 |
Replacement of an extruded segment of radius after autoclaving and sterilising with gentamicin.
Topics: Bone Nails; Bone Transplantation; Bone Wires; Elbow; Elbow Injuries; Forearm Injuries; Fracture Fixa | 2006 |
The use of prophylactic systemic antibiotics in compound depressed skull fractures in infancy and childhood.
Topics: Adolescent; Bacitracin; Bacterial Infections; Child; Child, Preschool; Female; Fractures, Open; Gent | 1981 |
[Results of long-term therapy of chronic, post-traumatic osteomyelitis with gentamycin PMMA chains].
Topics: Adolescent; Adult; Child; Chronic Disease; Combined Modality Therapy; Female; Follow-Up Studies; Fra | 1995 |
Irrigation and traction therapy for open fracture with large-sized full-thickness skin-deficit and severely infected wound.
Topics: Adolescent; Adult; Child; Female; Fractures, Open; Gentamicins; Humans; Male; Middle Aged; Multiple | 1995 |
Use of antibiotic-impregnated polymethyl methacrylate in horses with open or infected fractures or joints: 19 cases (1987-1995).
Topics: Amikacin; Animals; Anti-Bacterial Agents; Cefazolin; Combined Modality Therapy; Drug Therapy, Combin | 1997 |
Once daily high-dose gentamicin to prevent infection in open fractures of the tibial shaft: a preliminary investigation.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Debridement; Fractures, Open; Gent | 2001 |
Use of antibiotic-impregnated bone cement nail to treat septic nonunion after open tibial fracture.
Topics: Adult; Anti-Bacterial Agents; Bone Nails; Fracture Fixation, Intramedullary; Fractures, Open; Fractu | 2002 |
[The results of experimental and clinical use of Gentamycin PMMA balls (author's transl)].
Topics: Administration, Topical; Adult; Bone Nails; Bone Plates; Female; Fracture Fixation, Internal; Fractu | 1978 |
[Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma].
Topics: Anti-Infective Agents, Local; Cephalosporins; Fractures, Bone; Fractures, Open; Gentamicins; Humans; | 1992 |
[Use of a collagen-gentamicin compound in open spongiosaplasty in chronic post-traumatic osteomyelitis].
Topics: Adult; Anti-Infective Agents, Local; Bone Transplantation; Collagen; Combined Modality Therapy; Exte | 1990 |
[Local treatment of infection with gentamicin-PMMA chains and minichains].
Topics: Aged; Chronic Disease; Combined Modality Therapy; Female; Follow-Up Studies; Fracture Fixation, Inte | 1990 |
[Local treatment of infection with collagen gentamicin].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Bacterial Infections; Bone Transplanta | 1990 |
[Skin-soft tissue replacement on the lower leg--therapy and prophylaxis of osteomyelitis].
Topics: Accidents, Traffic; Adolescent; Adult; Bone Transplantation; Fracture Fixation, Internal; Fractures, | 1986 |
Implanted gentamicin beads in the treatment of osteomyelitis. A case report.
Topics: Aged; Fractures, Open; Gentamicins; Humans; Male; Methylmethacrylates; Osteomyelitis; Tibial Fractur | 1987 |