gentamicin has been researched along with Fractures, Bone in 26 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Fractures, Bone: Breaks in bones.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 10 cases of posttraumatic osteitis or osteomyelitis gentamicin-PMMA minichains have been used for treatment after radical local debridement." | 3.67 | [Medium term results of treatment of post-traumatic osteitis and osteomyelitis with gentamycin-PMMA minichains]. ( Quell, M; Vécsei, V, 1986) |
| "A patient with Pseudomonas aeruginosa pneumonia treated with gentamicin subsequently developed thoracovertebral osteomyelitis over the area of a preexisting compression fracture." | 3.65 | Vertebral osteomyelitis as a complication of Pseudomonas aeruginosa pneumonia. ( Watanakunakorn, C, 1975) |
| "The most serious complications in the treatment of open fractures and after procedures on bone tissue are infections." | 1.28 | [Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma]. ( Kateusz, J; Misterka, S, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (61.54) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, L | 1 |
| Fu, J | 1 |
| Zhou, Y | 1 |
| Chai, W | 1 |
| Zhang, G | 1 |
| Hao, L | 1 |
| Chen, J | 1 |
| Metsemakers, WJ | 1 |
| Moriarty, TF | 1 |
| Nijs, S | 1 |
| Pape, HC | 1 |
| Richards, RG | 1 |
| Alonge, TO | 1 |
| Ogunlade, SO | 1 |
| Fashina, AN | 1 |
| Khoo, PP | 1 |
| Michalak, KA | 1 |
| Yates, PJ | 1 |
| Megson, SM | 1 |
| Day, RE | 1 |
| Wood, DJ | 1 |
| Greene, AH | 1 |
| Bumgardner, JD | 1 |
| Yang, Y | 1 |
| Moseley, J | 1 |
| Haggard, WO | 1 |
| Goudarzi, YM | 1 |
| Asche, G | 1 |
| Börner, M | 1 |
| Klemm, K | 1 |
| Fabius, A | 1 |
| Vécsei, V | 2 |
| Scharf, W | 1 |
| Tomiczek, H | 1 |
| Bołoczko, S | 1 |
| Kołakowski, A | 1 |
| Bladowski, K | 1 |
| Jenny, G | 1 |
| TaglanG, G | 1 |
| Knapp, TP | 1 |
| Patzakis, MJ | 2 |
| Lee, J | 1 |
| Seipel, PR | 1 |
| Abdollahi, K | 1 |
| Reisch, RB | 1 |
| Rahmanzadeh, R | 1 |
| Enes-Gaiao, F | 1 |
| Watanakunakorn, C | 1 |
| Nunamaker, DM | 1 |
| Dorr, LD | 1 |
| Ivler, D | 1 |
| Moore, TM | 1 |
| Harvey, JP | 1 |
| Misterka, S | 2 |
| Kateusz, J | 2 |
| Skiba, K | 1 |
| Shaposhnikov, IuG | 1 |
| Kaveshnikov, AI | 1 |
| Kroĭtor, GM | 1 |
| Okropiridze, GG | 1 |
| Lipkin, SI | 1 |
| Ankin, LN | 1 |
| Polishchuk, NE | 1 |
| Ankin, NL | 1 |
| Quell, M | 1 |
| Zenker, H | 1 |
| Krämer, J | 1 |
| McHenry, MC | 1 |
| Dohn, DF | 1 |
| Tingwald, FR | 1 |
| Gavan, TL | 1 |
| Buchholz, HW | 1 |
| Engelbrecht, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Operative and Non-operative Treatment of Traumatic Arthrotomies: A Prospective Observational Study[NCT02841644] | 180 participants (Actual) | Observational | 2015-04-30 | Completed | |||
| Randomized Control Trial of Vancomycin Powder Following Posterior Instrumented Spinal Surgery for Trauma[NCT01977989] | Phase 4 | 140 participants (Anticipated) | Interventional | 2013-10-31 | Enrolling by invitation | ||
| Application of Antibiotic Loaded Calcium Sulfate as Prophylaxis for Patients With Non Modifiable Risk Factors for Periprosthetic Joint Infections[NCT03976466] | Phase 4 | 87 participants (Actual) | Interventional | 2019-05-22 | Completed | ||
| Comparative Effectiveness and Cost-Benefit Analysis of Vancomycin Powder in High Risk Spine Surgery Patients[NCT01566422] | 0 participants (Actual) | Interventional | 2012-06-30 | Withdrawn (stopped due to unable to enroll any participants) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complications were defined as septic arthritis, return to the OR, rehospitalization, and osteomyelitis of the injured joint. (NCT02841644)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Traumatic Arthrotomy- Treated Nonoperatively | 4 |
| Traumatic Arthrotomy- Treated Operatively | 18 |
To compare the cost of medical care in patients with traumatic arthrotomies treated with surgical irrigation and debridement versus non-operative treatment with local wound care. To estimate cost associated with TAs, total charge data was acquired for all patients treated at the lead site. (NCT02841644)
Timeframe: 12 months
| Intervention | USD (Median) |
|---|---|
| Traumatic Arthrotomy- Treated Nonoperatively | 1089 |
| Traumatic Arthrotomy- Treated Operatively | 11,973 |
The veteran rand 12-tem health survey is used to determine change in health related quality of life to estimate disease burden. It is summarized into two scores, a physical component scores (PCS) (range 0-100) and mental component scores (range- 0-100). Higher score indicate better outcomes. (NCT02841644)
Timeframe: baseline, 3 months
| Intervention | score on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| VR-12 Physical Health: Baseline | VR-12 Mental Health: Baseline | VR-12 Physical Health: 3 month | VR-12 Mental Health: 3 Month | VR-12 Physical Health: Difference | VR-12 Mental Health: Difference | |
| Traumatic Arthrotomy- Treated Nonoperatively | 49 | 50.7 | 36.9 | 41.9 | -12.2 | -8.8 |
| Traumatic Arthrotomy- Treated Operatively | 48.1 | 51.8 | 32.1 | 46.8 | -16.0 | -5.1 |
The length of stay is an important indicator of efficiency and hospital economic burden. The reduction in number of hospitalization days results in lower risk of infection and less medication side effects and decreased need of hospital supplies. The difference in the average days of hospitalization between both groups indirectly represents the economic cost spent by the hospital. (NCT03976466)
Timeframe: Surgical procedure day to hospital discharge.
| Intervention | Days (Mean) |
|---|---|
| Control Group | 15.25 |
| Calcium Sulfate Study Group | 4.6 |
2 reviews available for gentamicin and Fractures, Bone
| Article | Year |
|---|---|
Influence of implant properties and local delivery systems on the outcome in operative fracture care.
Topics: Anti-Bacterial Agents; Bone Cements; Bone Plates; Fracture Fixation, Internal; Fracture Healing; Fra | 2016 |
Comparison of intravenous and oral antibiotic therapy in the treatment of fractures caused by low-velocity gunshots. A prospective, randomized study of infection rates.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cephalosporin | 1996 |
1 trial available for gentamicin and Fractures, Bone
| Article | Year |
|---|---|
Comparison of intravenous and oral antibiotic therapy in the treatment of fractures caused by low-velocity gunshots. A prospective, randomized study of infection rates.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cephalosporin | 1996 |
24 other studies available for gentamicin and Fractures, Bone
| Article | Year |
|---|---|
Microbiological profiles and antibiotic resistance of periprosthetic joint infection after hip replacement in patients with fracture or non-fracture: A comparative study.
Topics: Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Cephalosporins; Clindamycin; Drug Resistance, | 2023 |
Microbial isolates in chronic osteomyelitis--a guide to management.
Topics: Anti-Bacterial Agents; Biopsy; Ceftriaxone; Chronic Disease; Drug Resistance, Bacterial; Female; Fra | 2002 |
Iontophoresis of antibiotics into segmental allografts.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthroplasty, Replacement; Bone R | 2006 |
Chitosan-coated stainless steel screws for fixation in contaminated fractures.
Topics: Anti-Bacterial Agents; Bacterial Infections; Bone Screws; Chitosan; Coated Materials, Biocompatible; | 2008 |
[Treatment of chronic post-traumatic infections of the bone and soft tissue with gentamycin PMMA beads (PMMA = polymethylmethacrylate) (author's transl)].
Topics: Adult; Bacterial Infections; Chronic Disease; Female; Fractures, Bone; Gentamicins; Humans; Male; Me | 1981 |
[Treatment and treatment results of infections of the hand with gentamicin PMMA minichains].
Topics: Adult; Female; Fracture Fixation, Internal; Fractures, Bone; Gentamicins; Hand Injuries; Humans; Mal | 1983 |
[Treatment of infected pseudarthroses by external fixation and temporary implantation of gentamicin chains].
Topics: Drug Implants; Fracture Fixation; Fractures, Bone; Gentamicins; Humans; Pseudarthrosis; Reoperation; | 1983 |
[Early fracture infection and its therapy].
Topics: Adult; Bone Transplantation; Female; Follow-Up Studies; Fracture Fixation; Fracture Fixation, Intern | 1982 |
[Use of PMMA gentamicin bead chains following early infection without the removal of osteosynthesis material].
Topics: Adolescent; Adult; Aged; Female; Fractures, Bone; Gentamicins; Humans; Male; Methylmethacrylates; Mi | 1983 |
[Our experience with the treatment of post-traumatic osteomyelitis of the long bone shafts].
Topics: Arm Injuries; Drainage; Drug Implants; Fractures, Bone; Gentamicins; Humans; Leg Injuries; Osteomyel | 1982 |
[Local osteomyelitis treatment with gentamycin PMMA ball chains].
Topics: Fracture Fixation, Internal; Fractures, Bone; Gentamicins; Methylmethacrylates; Osteomyelitis | 1980 |
[Results of stable osteosynthesis in existing postoperative osteomyelitis].
Topics: Adult; Bone Plates; Debridement; Female; Fracture Fixation, Internal; Fractures, Bone; Gentamicins; | 1979 |
Vertebral osteomyelitis as a complication of Pseudomonas aeruginosa pneumonia.
Topics: Carbenicillin; Fractures, Bone; Gentamicins; Humans; Male; Middle Aged; Osteomyelitis; Pneumonia; Ps | 1975 |
Management of infected fractures. Osteomyelitis.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bone Plates; Bone Screws; Bone Transplantation; Chron | 1975 |
The early management of open joint injuries. A prospective study of one hundred and forty patients.
Topics: Adult; Aged; Ankle Injuries; Drainage; Female; Femoral Fractures; Fractures, Bone; Gentamicins; Huma | 1975 |
[Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma].
Topics: Anti-Infective Agents, Local; Cephalosporins; Fractures, Bone; Fractures, Open; Gentamicins; Humans; | 1992 |
[Effect of septopal on kidney function during treatment of traumatic chronic inflammation of bones].
Topics: Chronic Disease; Creatinine; Fractures, Bone; Gentamicins; Humans; Kidney; Kidney Function Tests; Me | 1992 |
[Experimental substantiation of using gentacycol for prevention of wound infection in gunshot bone fractures of the extremities].
Topics: Animals; Arm Injuries; Bacterial Infections; Disease Models, Animal; Dogs; Drug Evaluation, Preclini | 1991 |
[Osteosynthesis in patients with associated cranio-cerebral trauma].
Topics: Arm Injuries; Brain Concussion; Craniocerebral Trauma; External Fixators; Fracture Fixation; Fractur | 1991 |
[Medium term results of treatment of post-traumatic osteitis and osteomyelitis with gentamycin-PMMA minichains].
Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Female; Follow-Up Studies; Fracture Fixation, In | 1986 |
[Pyocyanea infection in orthopedic surgery and its treatment].
Topics: Adult; Carbenicillin; Drug Synergism; Female; Fracture Fixation, Internal; Fractures, Bone; Gentamic | 1972 |
[Antibiotics in the bone surgery].
Topics: Ampicillin; Anti-Bacterial Agents; Bone and Bones; Carbenicillin; Fractures, Bone; Gentamicins; Huma | 1974 |
Meningitis due to Escherichia coli. Report of a case in a young adult treated with gentamicin.
Topics: Accidents, Traffic; Adolescent; Anti-Bacterial Agents; Escherichia coli; Escherichia coli Infections | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |
[Depot effects of various antibiotics mixed with Palacos resins].
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr | 1970 |