Page last updated: 2024-10-27

gentamicin and Fractures, Bone

gentamicin has been researched along with Fractures, Bone in 26 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Fractures, Bone: Breaks in bones.

Research Excerpts

ExcerptRelevanceReference
"In 10 cases of posttraumatic osteitis or osteomyelitis gentamicin-PMMA minichains have been used for treatment after radical local debridement."3.67[Medium term results of treatment of post-traumatic osteitis and osteomyelitis with gentamycin-PMMA minichains]. ( Quell, M; Vécsei, V, 1986)
"A patient with Pseudomonas aeruginosa pneumonia treated with gentamicin subsequently developed thoracovertebral osteomyelitis over the area of a preexisting compression fracture."3.65Vertebral osteomyelitis as a complication of Pseudomonas aeruginosa pneumonia. ( Watanakunakorn, C, 1975)
"The most serious complications in the treatment of open fractures and after procedures on bone tissue are infections."1.28[Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma]. ( Kateusz, J; Misterka, S, 1992)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199016 (61.54)18.7374
1990's5 (19.23)18.2507
2000's3 (11.54)29.6817
2010's1 (3.85)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Hu, L1
Fu, J1
Zhou, Y1
Chai, W1
Zhang, G1
Hao, L1
Chen, J1
Metsemakers, WJ1
Moriarty, TF1
Nijs, S1
Pape, HC1
Richards, RG1
Alonge, TO1
Ogunlade, SO1
Fashina, AN1
Khoo, PP1
Michalak, KA1
Yates, PJ1
Megson, SM1
Day, RE1
Wood, DJ1
Greene, AH1
Bumgardner, JD1
Yang, Y1
Moseley, J1
Haggard, WO1
Goudarzi, YM1
Asche, G1
Börner, M1
Klemm, K1
Fabius, A1
Vécsei, V2
Scharf, W1
Tomiczek, H1
Bołoczko, S1
Kołakowski, A1
Bladowski, K1
Jenny, G1
TaglanG, G1
Knapp, TP1
Patzakis, MJ2
Lee, J1
Seipel, PR1
Abdollahi, K1
Reisch, RB1
Rahmanzadeh, R1
Enes-Gaiao, F1
Watanakunakorn, C1
Nunamaker, DM1
Dorr, LD1
Ivler, D1
Moore, TM1
Harvey, JP1
Misterka, S2
Kateusz, J2
Skiba, K1
Shaposhnikov, IuG1
Kaveshnikov, AI1
Kroĭtor, GM1
Okropiridze, GG1
Lipkin, SI1
Ankin, LN1
Polishchuk, NE1
Ankin, NL1
Quell, M1
Zenker, H1
Krämer, J1
McHenry, MC1
Dohn, DF1
Tingwald, FR1
Gavan, TL1
Buchholz, HW1
Engelbrecht, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Operative and Non-operative Treatment of Traumatic Arthrotomies: A Prospective Observational Study[NCT02841644]180 participants (Actual)Observational2015-04-30Completed
Randomized Control Trial of Vancomycin Powder Following Posterior Instrumented Spinal Surgery for Trauma[NCT01977989]Phase 4140 participants (Anticipated)Interventional2013-10-31Enrolling by invitation
Application of Antibiotic Loaded Calcium Sulfate as Prophylaxis for Patients With Non Modifiable Risk Factors for Periprosthetic Joint Infections[NCT03976466]Phase 487 participants (Actual)Interventional2019-05-22Completed
Comparative Effectiveness and Cost-Benefit Analysis of Vancomycin Powder in High Risk Spine Surgery Patients[NCT01566422]0 participants (Actual)Interventional2012-06-30Withdrawn (stopped due to unable to enroll any participants)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Complications

Complications were defined as septic arthritis, return to the OR, rehospitalization, and osteomyelitis of the injured joint. (NCT02841644)
Timeframe: 12 months

InterventionParticipants (Count of Participants)
Traumatic Arthrotomy- Treated Nonoperatively4
Traumatic Arthrotomy- Treated Operatively18

Cost of Treatments

To compare the cost of medical care in patients with traumatic arthrotomies treated with surgical irrigation and debridement versus non-operative treatment with local wound care. To estimate cost associated with TAs, total charge data was acquired for all patients treated at the lead site. (NCT02841644)
Timeframe: 12 months

InterventionUSD (Median)
Traumatic Arthrotomy- Treated Nonoperatively1089
Traumatic Arthrotomy- Treated Operatively11,973

Comparing 3-Month Change in Veterans RAND 12-Item Health Survey (VR-12) by Treatment Method

The veteran rand 12-tem health survey is used to determine change in health related quality of life to estimate disease burden. It is summarized into two scores, a physical component scores (PCS) (range 0-100) and mental component scores (range- 0-100). Higher score indicate better outcomes. (NCT02841644)
Timeframe: baseline, 3 months

,
Interventionscore on a scale (Mean)
VR-12 Physical Health: BaselineVR-12 Mental Health: BaselineVR-12 Physical Health: 3 monthVR-12 Mental Health: 3 MonthVR-12 Physical Health: DifferenceVR-12 Mental Health: Difference
Traumatic Arthrotomy- Treated Nonoperatively4950.736.941.9-12.2-8.8
Traumatic Arthrotomy- Treated Operatively48.151.832.146.8-16.0-5.1

Length of Stay as an Indicator of the Hospital Economic Burden

The length of stay is an important indicator of efficiency and hospital economic burden. The reduction in number of hospitalization days results in lower risk of infection and less medication side effects and decreased need of hospital supplies. The difference in the average days of hospitalization between both groups indirectly represents the economic cost spent by the hospital. (NCT03976466)
Timeframe: Surgical procedure day to hospital discharge.

InterventionDays (Mean)
Control Group15.25
Calcium Sulfate Study Group4.6

Reviews

2 reviews available for gentamicin and Fractures, Bone

ArticleYear
Influence of implant properties and local delivery systems on the outcome in operative fracture care.
    Injury, 2016, Volume: 47, Issue:3

    Topics: Anti-Bacterial Agents; Bone Cements; Bone Plates; Fracture Fixation, Internal; Fracture Healing; Fra

2016
Comparison of intravenous and oral antibiotic therapy in the treatment of fractures caused by low-velocity gunshots. A prospective, randomized study of infection rates.
    The Journal of bone and joint surgery. American volume, 1996, Volume: 78, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cephalosporin

1996

Trials

1 trial available for gentamicin and Fractures, Bone

ArticleYear
Comparison of intravenous and oral antibiotic therapy in the treatment of fractures caused by low-velocity gunshots. A prospective, randomized study of infection rates.
    The Journal of bone and joint surgery. American volume, 1996, Volume: 78, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cephalosporin

1996

Other Studies

24 other studies available for gentamicin and Fractures, Bone

ArticleYear
Microbiological profiles and antibiotic resistance of periprosthetic joint infection after hip replacement in patients with fracture or non-fracture: A comparative study.
    Journal of back and musculoskeletal rehabilitation, 2023, Volume: 36, Issue:1

    Topics: Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Cephalosporins; Clindamycin; Drug Resistance,

2023
Microbial isolates in chronic osteomyelitis--a guide to management.
    African journal of medicine and medical sciences, 2002, Volume: 31, Issue:2

    Topics: Anti-Bacterial Agents; Biopsy; Ceftriaxone; Chronic Disease; Drug Resistance, Bacterial; Female; Fra

2002
Iontophoresis of antibiotics into segmental allografts.
    The Journal of bone and joint surgery. British volume, 2006, Volume: 88, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthroplasty, Replacement; Bone R

2006
Chitosan-coated stainless steel screws for fixation in contaminated fractures.
    Clinical orthopaedics and related research, 2008, Volume: 466, Issue:7

    Topics: Anti-Bacterial Agents; Bacterial Infections; Bone Screws; Chitosan; Coated Materials, Biocompatible;

2008
[Treatment of chronic post-traumatic infections of the bone and soft tissue with gentamycin PMMA beads (PMMA = polymethylmethacrylate) (author's transl)].
    Aktuelle Traumatologie, 1981, Volume: 11, Issue:1

    Topics: Adult; Bacterial Infections; Chronic Disease; Female; Fractures, Bone; Gentamicins; Humans; Male; Me

1981
[Treatment and treatment results of infections of the hand with gentamicin PMMA minichains].
    Zentralblatt fur Chirurgie, 1983, Volume: 108, Issue:11

    Topics: Adult; Female; Fracture Fixation, Internal; Fractures, Bone; Gentamicins; Hand Injuries; Humans; Mal

1983
[Treatment of infected pseudarthroses by external fixation and temporary implantation of gentamicin chains].
    Chirurgia narzadow ruchu i ortopedia polska, 1983, Volume: 48, Issue:1

    Topics: Drug Implants; Fracture Fixation; Fractures, Bone; Gentamicins; Humans; Pseudarthrosis; Reoperation;

1983
[Early fracture infection and its therapy].
    Hefte zur Unfallheilkunde, 1982, Volume: 157

    Topics: Adult; Bone Transplantation; Female; Follow-Up Studies; Fracture Fixation; Fracture Fixation, Intern

1982
[Use of PMMA gentamicin bead chains following early infection without the removal of osteosynthesis material].
    Unfallheilkunde, 1983, Volume: 86, Issue:1

    Topics: Adolescent; Adult; Aged; Female; Fractures, Bone; Gentamicins; Humans; Male; Methylmethacrylates; Mi

1983
[Our experience with the treatment of post-traumatic osteomyelitis of the long bone shafts].
    Chirurgia narzadow ruchu i ortopedia polska, 1982, Volume: 47, Issue:5-6

    Topics: Arm Injuries; Drainage; Drug Implants; Fractures, Bone; Gentamicins; Humans; Leg Injuries; Osteomyel

1982
[Local osteomyelitis treatment with gentamycin PMMA ball chains].
    Beitrage zur Orthopadie und Traumatologie, 1980, Volume: 27, Issue:8

    Topics: Fracture Fixation, Internal; Fractures, Bone; Gentamicins; Methylmethacrylates; Osteomyelitis

1980
[Results of stable osteosynthesis in existing postoperative osteomyelitis].
    Hefte zur Unfallheilkunde, 1979, Volume: 138

    Topics: Adult; Bone Plates; Debridement; Female; Fracture Fixation, Internal; Fractures, Bone; Gentamicins;

1979
Vertebral osteomyelitis as a complication of Pseudomonas aeruginosa pneumonia.
    Southern medical journal, 1975, Volume: 68, Issue:2

    Topics: Carbenicillin; Fractures, Bone; Gentamicins; Humans; Male; Middle Aged; Osteomyelitis; Pneumonia; Ps

1975
Management of infected fractures. Osteomyelitis.
    The Veterinary clinics of North America, 1975, Volume: 5, Issue:2

    Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bone Plates; Bone Screws; Bone Transplantation; Chron

1975
The early management of open joint injuries. A prospective study of one hundred and forty patients.
    The Journal of bone and joint surgery. American volume, 1975, Volume: 57, Issue:8

    Topics: Adult; Aged; Ankle Injuries; Drainage; Female; Femoral Fractures; Fractures, Bone; Gentamicins; Huma

1975
[Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma].
    Polimery w medycynie, 1992, Volume: 22, Issue:3

    Topics: Anti-Infective Agents, Local; Cephalosporins; Fractures, Bone; Fractures, Open; Gentamicins; Humans;

1992
[Effect of septopal on kidney function during treatment of traumatic chronic inflammation of bones].
    Polimery w medycynie, 1992, Volume: 22, Issue:3

    Topics: Chronic Disease; Creatinine; Fractures, Bone; Gentamicins; Humans; Kidney; Kidney Function Tests; Me

1992
[Experimental substantiation of using gentacycol for prevention of wound infection in gunshot bone fractures of the extremities].
    Ortopediia travmatologiia i protezirovanie, 1991, Issue:6

    Topics: Animals; Arm Injuries; Bacterial Infections; Disease Models, Animal; Dogs; Drug Evaluation, Preclini

1991
[Osteosynthesis in patients with associated cranio-cerebral trauma].
    Ortopediia travmatologiia i protezirovanie, 1991, Issue:6

    Topics: Arm Injuries; Brain Concussion; Craniocerebral Trauma; External Fixators; Fracture Fixation; Fractur

1991
[Medium term results of treatment of post-traumatic osteitis and osteomyelitis with gentamycin-PMMA minichains].
    Aktuelle Traumatologie, 1986, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Female; Follow-Up Studies; Fracture Fixation, In

1986
[Pyocyanea infection in orthopedic surgery and its treatment].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1972, Volume: 110, Issue:5

    Topics: Adult; Carbenicillin; Drug Synergism; Female; Fracture Fixation, Internal; Fractures, Bone; Gentamic

1972
[Antibiotics in the bone surgery].
    Fortschritte der Medizin, 1974, Jun-20, Volume: 92, Issue:18

    Topics: Ampicillin; Anti-Bacterial Agents; Bone and Bones; Carbenicillin; Fractures, Bone; Gentamicins; Huma

1974
Meningitis due to Escherichia coli. Report of a case in a young adult treated with gentamicin.
    JAMA, 1970, Apr-06, Volume: 212, Issue:1

    Topics: Accidents, Traffic; Adolescent; Anti-Bacterial Agents; Escherichia coli; Escherichia coli Infections

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970
[Depot effects of various antibiotics mixed with Palacos resins].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1970, Volume: 41, Issue:11

    Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Compounding; Dr

1970