gentamicin has been researched along with Femoral Fractures in 18 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Femoral Fractures: Fractures of the femur.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigates the use of such scaffolds with gentamicin (along with bone morphogenetic protein) in an infected rat open fracture model to decrease osteomyelitis and promote fracture healing." | 3.76 | The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model. ( Chu, TM; Cox, JT; Duffy, L; Stannard, J; Stewart, RL; Volgas, D; Waites, KB, 2010) |
| "To evaluate a new gentamicin-vancomycin- impregnated (2:1) PMMA coating nail as a drug delivery device to treat bone and intramedullary infections, methicillin-resistant Staphylococcus aureus (MRSA) was used to induce femoral osteomyelitis in 20 New Zealand male rabbits." | 3.74 | Preliminary investigations on a new gentamicin and vancomycin-coated PMMA nail for the treatment of bone and intramedullary infections: An experimental study in the rabbit. ( Borsari, V; Fini, M; Gaibani, P; Giardino, R; Giavaresi, G; Sambri, V; Soffiatti, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Roukoz, S | 1 |
| El Khoury, G | 1 |
| Saghbini, E | 1 |
| Saliba, I | 1 |
| Khazzaka, A | 1 |
| Rizkallah, M | 1 |
| Freischmidt, H | 1 |
| Armbruster, J | 1 |
| Bonner, E | 1 |
| Guehring, T | 1 |
| Nurjadi, D | 1 |
| Bechberger, M | 1 |
| Sonntag, R | 1 |
| Schmidmaier, G | 1 |
| Grützner, PA | 1 |
| Helbig, L | 1 |
| Penn-Barwell, JG | 1 |
| Murray, CK | 1 |
| Wenke, JC | 1 |
| Nau, C | 1 |
| Seebach, C | 1 |
| Trumm, A | 1 |
| Schaible, A | 1 |
| Kontradowitz, K | 1 |
| Meier, S | 1 |
| Buechner, H | 1 |
| Marzi, I | 1 |
| Henrich, D | 1 |
| Möllering, N | 1 |
| Lenhartz, H | 1 |
| Stegmann, J | 1 |
| Höger, P | 1 |
| Aly, EE | 1 |
| Sivasubramaniam, SK | 1 |
| Bhatti, TH | 1 |
| Sanaka, R | 1 |
| Stewart, RL | 1 |
| Cox, JT | 1 |
| Volgas, D | 1 |
| Stannard, J | 1 |
| Duffy, L | 1 |
| Waites, KB | 1 |
| Chu, TM | 1 |
| Giavaresi, G | 1 |
| Borsari, V | 1 |
| Fini, M | 1 |
| Giardino, R | 1 |
| Sambri, V | 1 |
| Gaibani, P | 1 |
| Soffiatti, R | 1 |
| Müller, KH | 1 |
| Müller-Färber, J | 1 |
| Musher, D | 1 |
| Weingarten, NM | 1 |
| Andrys, I | 1 |
| Jabłecka, A | 1 |
| Krüger-Franke, M | 1 |
| Carl, C | 1 |
| Haus, J | 1 |
| Tandon, SC | 1 |
| Thomas, PB | 1 |
| Patzakis, MJ | 1 |
| Dorr, LD | 1 |
| Ivler, D | 1 |
| Moore, TM | 1 |
| Harvey, JP | 1 |
| Schmidt, HG | 1 |
| Wittek, F | 1 |
| Faschingbauer, M | 1 |
| Fink, B | 1 |
| Ascherl, R | 1 |
| Stemberg, A | 1 |
| Lechner, F | 1 |
| Blümel, G | 1 |
| Weise, K | 1 |
| Müller, HP | 1 |
| Schroeder, SA | 1 |
| Catino, D | 1 |
| Toala, P | 1 |
| Finland, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Operative and Non-operative Treatment of Traumatic Arthrotomies: A Prospective Observational Study[NCT02841644] | 180 participants (Actual) | Observational | 2015-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complications were defined as septic arthritis, return to the OR, rehospitalization, and osteomyelitis of the injured joint. (NCT02841644)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Traumatic Arthrotomy- Treated Nonoperatively | 4 |
| Traumatic Arthrotomy- Treated Operatively | 18 |
To compare the cost of medical care in patients with traumatic arthrotomies treated with surgical irrigation and debridement versus non-operative treatment with local wound care. To estimate cost associated with TAs, total charge data was acquired for all patients treated at the lead site. (NCT02841644)
Timeframe: 12 months
| Intervention | USD (Median) |
|---|---|
| Traumatic Arthrotomy- Treated Nonoperatively | 1089 |
| Traumatic Arthrotomy- Treated Operatively | 11,973 |
The veteran rand 12-tem health survey is used to determine change in health related quality of life to estimate disease burden. It is summarized into two scores, a physical component scores (PCS) (range 0-100) and mental component scores (range- 0-100). Higher score indicate better outcomes. (NCT02841644)
Timeframe: baseline, 3 months
| Intervention | score on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| VR-12 Physical Health: Baseline | VR-12 Mental Health: Baseline | VR-12 Physical Health: 3 month | VR-12 Mental Health: 3 Month | VR-12 Physical Health: Difference | VR-12 Mental Health: Difference | |
| Traumatic Arthrotomy- Treated Nonoperatively | 49 | 50.7 | 36.9 | 41.9 | -12.2 | -8.8 |
| Traumatic Arthrotomy- Treated Operatively | 48.1 | 51.8 | 32.1 | 46.8 | -16.0 | -5.1 |
18 other studies available for gentamicin and Femoral Fractures
| Article | Year |
|---|---|
Does the induced membrane have antibacterial properties? An experimental rat model of a chronic infected nonunion.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Bone Cements; Bone Transplantation; Chronic | 2020 |
Systemic Administration of PTH Supports Vascularization in Segmental Bone Defects Filled with Ceramic-Based Bone Graft Substitute.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Regeneration; Bone Remodeling | 2021 |
Local antibiotic delivery by a bioabsorbable gel is superior to PMMA bead depot in reducing infection in an open fracture model.
Topics: Absorbable Implants; Administration, Topical; Animals; Anti-Bacterial Agents; Disease Models, Animal | 2014 |
Alteration of Masquelet's induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat's femur.
Topics: Animals; Anti-Bacterial Agents; Bone Cements; Clindamycin; Disease Models, Animal; Femoral Fractures | 2016 |
[Imported Bacteremia].
Topics: Administration, Oral; Arteries; Arthralgia; Bacteremia; Brucella melitensis; Brucellosis; Child; Dia | 2016 |
Endotoxin-like reaction following once-daily gentamicin.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Endotoxemia; Femoral Fractures; Femur Neck; Gentamicins; H | 2009 |
The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model.
Topics: Absorbable Implants; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Carriers; Femoral | 2010 |
Preliminary investigations on a new gentamicin and vancomycin-coated PMMA nail for the treatment of bone and intramedullary infections: An experimental study in the rabbit.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Bone Nails; Coated Materials, Biocompatible; Combined Moda | 2008 |
Femur osteomyelitis following medullary nailing.
Topics: Adolescent; Adult; Bone Nails; Debridement; Female; Femoral Fractures; Femur; Fracture Fixation, Int | 1982 |
A 100-foot fall.
Topics: Adult; Athletic Injuries; Carbenicillin; Cephalosporins; Debridement; Femoral Fractures; Gentamicins | 1980 |
[Assessment of gentamicin dosage in patients before planned surgical operation].
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cholecystectomy; Drug Administration Schedule; | 1994 |
[Treatment of infected intramedullary osteosynthesis. A comparison of various therapeutic procedures].
Topics: Adolescent; Adult; Bone Transplantation; Combined Modality Therapy; External Fixators; Female; Femor | 1993 |
Persistent osteomyelitis of the femur--2 cases of exchange intramedullary nailing with gentamicin beads in the nail.
Topics: Adult; Anti-Bacterial Agents; Arthrodesis; Femoral Fractures; Fracture Fixation, Intramedullary; Fra | 1996 |
The early management of open joint injuries. A prospective study of one hundred and forty patients.
Topics: Adult; Aged; Ankle Injuries; Drainage; Female; Femoral Fractures; Fractures, Bone; Gentamicins; Huma | 1975 |
[Treatment of chronic osteitis of the femur].
Topics: Adult; Aged; Aged, 80 and over; Bone Lengthening; Bone Transplantation; Combined Modality Therapy; E | 1992 |
[Local treatment of infection with collagen gentamicin].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Bacterial Infections; Bone Transplanta | 1990 |
[Local antibiotic therapy in postoperative and post-traumatic osteitis with the Septopal chain].
Topics: Femoral Fractures; Fracture Fixation, Internal; Gentamicins; Humans; Methylmethacrylates; Osteitis; | 1988 |
Chronic pseudomonas osteomyelitis. Report on the use of gentamicin sulphate in three cases.
Topics: Adult; Female; Femoral Fractures; Fracture Fixation, Internal; Gentamicins; Humans; Male; Middle Age | 1970 |