gentamicin has been researched along with Epidermolysis Bullosa, Junctional in 6 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Epidermolysis Bullosa, Junctional: Form of epidermolysis bullosa having onset at birth or during the neonatal period and transmitted through autosomal recessive inheritance. It is characterized by generalized blister formation, extensive denudation, and separation and cleavage of the basal cell plasma membranes from the basement membrane.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gentamicin-treated wounds exhibited increased expression of laminin 332 at the dermal-epidermal junction for at least 3 months and were associated with improved wound closure." | 2.94 | Gentamicin Induces Laminin 332 and Improves Wound Healing in Junctional Epidermolysis Bullosa Patients with Nonsense Mutations. ( Antaya, R; Chen, M; Chen, Q; Cogan, J; Hao, M; Hou, Y; Kim, G; Kwong, A; Lincoln, V; Woodley, DT, 2020) |
| "Gentamicin application was well tolerated, long hospitalization was not required." | 1.51 | Attenuation of Severe Generalized Junctional Epidermolysis Bullosa by Systemic Treatment with Gentamicin. ( Hammersen, J; Neuner, A; Schneider, H; Wild, F, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mosallaei, D | 1 |
| Hao, M | 3 |
| Antaya, RJ | 1 |
| Levian, B | 1 |
| Kwong, A | 2 |
| Cogan, J | 3 |
| Hamilton, C | 1 |
| Schwieger-Briel, A | 1 |
| Tan, C | 1 |
| Tang, X | 1 |
| Woodley, DT | 3 |
| Chen, M | 3 |
| Li, Y | 1 |
| Shen, J | 1 |
| Liang, J | 1 |
| Zheng, L | 1 |
| Chen, F | 1 |
| Yao, Z | 1 |
| Li, M | 1 |
| Hou, Y | 2 |
| Antaya, R | 1 |
| Kim, G | 1 |
| Lincoln, V | 2 |
| Chen, Q | 1 |
| Hung, JH | 1 |
| Hou, PC | 1 |
| Huang, FC | 1 |
| Hsu, CK | 1 |
| Hirsch, M | 1 |
| Alexeev, V | 1 |
| De Luca, M | 1 |
| De Rosa, L | 1 |
| Bauer, JW | 1 |
| Hammersen, J | 1 |
| Neuner, A | 1 |
| Wild, F | 1 |
| Schneider, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of the Restoration of Functional Laminin 332 in JEB Patients With Nonsense Mutations After Topical and Intravenous Gentamicin Treatment[NCT03526159] | Phase 1/Phase 2 | 6 participants (Anticipated) | Interventional | 2018-06-01 | Recruiting | ||
| Optimization of Intravenous Gentamicin Treatment to Restore Functional Laminin 332 in JEB Patients With Nonsense Mutations[NCT04140786] | Phase 1/Phase 2 | 6 participants (Anticipated) | Interventional | 2019-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for gentamicin and Epidermolysis Bullosa, Junctional
| Article | Year |
|---|---|
Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants.
Topics: Alleles; Child; Epidermolysis Bullosa, Junctional; Female; Gentamicins; Humans; Infant; Laminin; Mal | 2022 |
Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants.
Topics: Alleles; Child; Epidermolysis Bullosa, Junctional; Female; Gentamicins; Humans; Infant; Laminin; Mal | 2022 |
Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants.
Topics: Alleles; Child; Epidermolysis Bullosa, Junctional; Female; Gentamicins; Humans; Infant; Laminin; Mal | 2022 |
Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants.
Topics: Alleles; Child; Epidermolysis Bullosa, Junctional; Female; Gentamicins; Humans; Infant; Laminin; Mal | 2022 |
Gentamicin Induces Laminin 332 and Improves Wound Healing in Junctional Epidermolysis Bullosa Patients with Nonsense Mutations.
Topics: Administration, Cutaneous; Anti-Bacterial Agents; Cell Adhesion Molecules; Cell Survival; Cells, Cul | 2020 |
4 other studies available for gentamicin and Epidermolysis Bullosa, Junctional
| Article | Year |
|---|---|
Gentamicin induces COL17A1 nonsense mutation readthrough in junctional epidermolysis bullosa.
Topics: Autoantigens; Codon, Nonsense; Collagen Type XVII; Epidermolysis Bullosa, Junctional; Gentamicins; H | 2020 |
Topical gentamicin ointment induces LAMB3 nonsense mutation readthrough and improves corneal erosions in a patient with junctional epidermolysis bullosa.
Topics: Cell Adhesion Molecules; Codon, Nonsense; Epidermolysis Bullosa, Junctional; Gentamicins; Humans; Ka | 2021 |
Gentamicin induces
Topics: Cell Adhesion Molecules; Codon, Nonsense; Epidermolysis Bullosa, Junctional; Gentamicins; HEK293 Cel | 2018 |
Attenuation of Severe Generalized Junctional Epidermolysis Bullosa by Systemic Treatment with Gentamicin.
Topics: Anti-Bacterial Agents; Epidermolysis Bullosa, Junctional; Female; Gentamicins; Humans; Infant; Injec | 2019 |