gentamicin and Ear Diseases studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Ear Diseases: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Research Excerpts

Excerpt	Relevance	Reference
"Gentamicin is widely used in the treatment of suspected or proven neonatal sepsis."	8.83	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Ahmed, M; Hagan, R; Rao, SC, 2006)
"Gentamicin and the other aminoglycosides are toxic antibiotics, but they are urgently needed to treat newborns with neonatal sepsis."	5.17	Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. ( Dwijayanti, A; Louisa, M; Rundjan, L; Setiabudy, R; Simanjuntak, E; Suwento, R; Yasin, FH, 2013)
"Gentamicin is widely used in the treatment of suspected or proven neonatal sepsis."	4.83	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Ahmed, M; Hagan, R; Rao, SC, 2006)
"Gentamicin is used in pregnancy to treat infections that cause complications to the mother and fetus if left untreated."	3.74	Is gentamicin ototoxic to the fetus? ( Harris, C; Kirkwood, A; Koren, G; Timar, N, 2007)
"To examine the safety and efficacy of once-daily (OD) gentamicin treatment compared with conventional 8-hourly dosing (TDS) for urinary tract infection (UTI)."	2.71	Treatment of urinary tract infection with gentamicin once or three times daily. ( Balakrishnan, A; Chao, SM; Chong, CY; Ng, W; Tan, AS; Tan-Kendrick, A, 2003)
" The advantages and disadvantages of arbitrary, predictive, and pharmacokinetic methods of dosing determination are summarized."	2.37	Clinical pharmacokinetics, toxicity and cost effectiveness analysis of aminoglycosides and aminoglycoside dosing services. ( Bailie, GR; Mathews, A, 1987)
"Gentamicin was given by the intraperitoneal route in a dose of 120 mg/kg/day."	1.46	Evaluation of the possible protective role of naringenin on gentamicin-induced ototoxicity: A preliminary study. ( Akakın, D; Aydogan, E; Koçak, I; Koroglu, K; Özer, ÖF; Sarac, S; Şentürk, E, 2017)
"Current data indicate that once-daily aminoglycoside therapy is as efficacious as traditional multiple daily dosing and equally or less toxic."	1.29	Once-daily aminoglycoside therapy: potential ototoxicity. ( Krieff, D; Singer, C; Smith, C, 1996)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (46.67)	18.7374
1990's	7 (15.56)	18.2507
2000's	7 (15.56)	29.6817
2010's	9 (20.00)	24.3611
2020's	1 (2.22)	2.80

Authors	Studies
Svistushkin, VM	1
Nikiforova, GN	1
Shevchik, EA	1
Zolotova, AV	1
Koçak, I	1
Sarac, S	1
Aydogan, E	1
Şentürk, E	1
Akakın, D	1
Koroglu, K	1
Özer, ÖF	1
Boyd, M	1
Santoro, D	1
Gram, D	1
Setiabudy, R	1
Suwento, R	1
Rundjan, L	1
Yasin, FH	1
Louisa, M	1
Dwijayanti, A	1
Simanjuntak, E	1
Samiee-Zafarghandy, S	1
van den Anker, JN	1
McAfee, JS	1
Benson, C	1
Spangenberg, D	1
Lattanzio, F	1
Strasnick, B	1
Liu, K	1
Chen, D	1
Guo, W	1
Yu, N	1
Wang, X	1
Ji, F	1
Hou, Z	1
Yang, WY	1
Yang, S	1
Somdaş, MA	1
Korkmaz, F	2
Gürgen, SG	2
Sagit, M	2
Akçadağ, A	2
Musiime, GM	1
Seale, AC	1
Moxon, SG	1
Lawn, JE	1
Gundogdu, R	1
Ozcan, I	1
Wooltorton, E	1
Rutka, J	1
Chong, CY	1
Tan, AS	1
Ng, W	1
Tan-Kendrick, A	1
Balakrishnan, A	1
Chao, SM	1
Rao, SC	1
Ahmed, M	1
Hagan, R	1
Kirkwood, A	1
Harris, C	1
Timar, N	1
Koren, G	1
Clamp, PJ	1
Daschner, FD	1
Just, HM	1
Jansen, W	1
Lorber, R	1
Noone, P	1
Legge, JW	1
Parravicini, L	1
Arpini, A	1
Bamonte, F	1
Marzanatti, M	1
Ongini, E	1
Winerman, I	1
Segal, S	1
Man, A	1
Gonzalez, P	1
Aguado, JM	1
Martin, MA	1
Fernandez-Chacon, T	1
Ortuño, B	1
Ferriols-Lisart, R	1
Alós-Almiñana, M	1
Singer, C	1
Smith, C	1
Krieff, D	1
Lang, H	1
Liu, C	1
Reiss, M	1
Silverstein, H	1
Laurell, G	1
Viberg, A	1
Teixeira, M	1
Sterkers, O	1
Ferrary, E	1
Appel, GB	1
Neu, HC	1
Federspil, P	1
Weichselbaumer, W	1
Gorz, E	1
Christensen, EF	1
Reiffenstein, JC	1
Madissoo, H	1
Hansen, MM	1
Winkel, O	1
Kaaber, K	1
Rozarth, K	1
Gendeh, BS	1
Said, H	1
Gibb, AG	1
Aziz, NS	1
Zahir, ZM	1
Mathews, A	1
Bailie, GR	1
Veldman, JE	2
Meeuwsen, F	2
Huizing, EH	2
van Dijk, M	1
Key, Q	1
Takada, A	1
Bledsoe, S	1
Schacht, J	1
McGhie, D	1
Hutchison, JG	1
Geddes, AM	1
Selavri, TV	1
Debain, JJ	1
Freyss, G	1
Poulain, H	1
Roydhouse, N	1
Dayal, VS	1
Smith, EL	1
McCain, WG	1
Kilcoyne, AG	1
Leigh, DA	1

Trial	Enrollment	Study Type	Start Date	Status
Aminoglycoside Plasma Level Measurement in Neonates With Infection[NCT01624324]	25 participants (Anticipated)	Observational	2010-11-30	Recruiting
Auditive and Renal Long Term Outcomes - Risk After Aminoglycoside Therapy in Neonates (AURORA-study)[NCT03253614]	226 participants (Actual)	Observational	2017-09-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Modern aspects of inflammatory external ear diseases treatment]. Vestnik otorinolaringologii, 2021, Volume: 86, Issue:3 Topics: Anti-Inflammatory Agents; Clotrimazole; Ear Canal; Ear Diseases; Gentamicins; Humans; Otitis Externa	2021
Risk of gentamicin toxicity in neonates treated for possible severe bacterial infection in low- and middle-income countries: Systematic Review. Tropical medicine & international health : TM & IH, 2015, Volume: 20, Issue:12 Topics: Anti-Bacterial Agents; Bacterial Infections; Developing Countries; Ear Diseases; Gentamicins; Humans	2015
One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. The Cochrane database of systematic reviews, 2006, Jan-25, Issue:1 Topics: Anti-Bacterial Agents; Drug Administration Schedule; Ear Diseases; Gentamicins; Humans; Infant, Newb	2006
Effectiveness and safety of once-daily aminoglycosides: a meta-analysis. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, May-15, Volume: 53, Issue:10 Topics: Adult; Aged; Amikacin; Anti-Bacterial Agents; Controlled Clinical Trials as Topic; Drug Administrati	1996
Use of a new device, the MicroWick, to deliver medication to the inner ear. Ear, nose, & throat journal, 1999, Volume: 78, Issue:8 Topics: Anti-Bacterial Agents; Autoimmune Diseases; Dexamethasone; Drug Delivery Systems; Ear Diseases; Ear,	1999
Gentamicin in 1978. Annals of internal medicine, 1978, Volume: 89, Issue:4 Topics: Amikacin; Animals; Bacterial Infections; Drug Synergism; Ear Diseases; Gentamicins; Humans; Kidney;	1978
Clinical pharmacokinetics, toxicity and cost effectiveness analysis of aminoglycosides and aminoglycoside dosing services. Journal of clinical pharmacy and therapeutics, 1987, Volume: 12, Issue:5 Topics: Amikacin; Aminoglycosides; Cost-Benefit Analysis; Ear Diseases; Gentamicins; Humans; Kidney Diseases	1987
[Side effects of antibiotics-aminoglycosides]. Sovetskaia meditsina, 1972, Volume: 35, Issue:7 Topics: Age Factors; Aged; Animals; Anti-Bacterial Agents; Deafness; Drug Resistance, Microbial; Ear Disease	1972

Article	Year
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Treatment of urinary tract infection with gentamicin once or three times daily. Acta paediatrica (Oslo, Norway : 1992), 2003, Volume: 92, Issue:3 Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Drug Administration Schedule; Ear Diseas	2003
Netilmicin versus tobramycin in multi-centre studies. The Journal of antimicrobial chemotherapy, 1984, Volume: 13 Suppl A Topics: Acute Kidney Injury; Aged; Bacterial Infections; Clinical Trials as Topic; Ear Diseases; Female; Gen	1984
Netilmicin in the treatment of immunocompromised patients. The Journal of antimicrobial chemotherapy, 1984, Volume: 13 Suppl A Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topic; Drug Therapy	1984
Effectiveness of prophylactic antibiotic treatment in mastoid surgery. The American journal of otology, 1981, Volume: 3, Issue:1 Topics: Adolescent; Adult; Aged; Child; Clindamycin; Ear Diseases; Female; Gentamicins; Humans; Male; Mastoi	1981
Once-daily aminoglycoside dosing. Lancet (London, England), 1993, Apr-03, Volume: 341, Issue:8849 Topics: Drug Administration Schedule; Ear Diseases; Gentamicins; Humans; Infections; Kidney Diseases; Prospe	1993
Gentamicin-hydrocortisone ear-drops in chronic infections. The Practitioner, 1973, Volume: 211, Issue:261 Topics: Bacterial Infections; Clinical Trials as Topic; Ear Diseases; Gentamicins; Humans; Hydrocortisone	1973

gentamicin and Ear Diseases

Research Excerpts

Research

Studies (45)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Evaluation of the possible protective role of naringenin on gentamicin-induced ototoxicity: A preliminary study. International journal of pediatric otorhinolaryngology, 2017, Volume: 100 Topics: Animals; Anti-Bacterial Agents; Antioxidants; Apoptosis; Cochlea; Ear Diseases; Ear, Inner; Evoked P	2017
In vitro antimicrobial activity of topical otological antimicrobials and Tris-EDTA against resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa isolates from dogs. Veterinary dermatology, 2019, Volume: 30, Issue:2 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Dogs; Drug Resistance, Multiple, Bacte	2019
Aminoglycosides and ototoxicity in neonates: is there a relation with serum concentrations? International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:12 Topics: Amikacin; Anti-Bacterial Agents; Ear Diseases; Female; Gentamicins; Hearing; Humans; Male; Sepsis	2013
Jellyfish model for ototoxicity. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2015, Volume: 36, Issue:2 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ear Diseases; Gentamicins; Hair C	2015
Spontaneous and Partial Repair of Ribbon Synapse in Cochlear Inner Hair Cells After Ototoxic Withdrawal. Molecular neurobiology, 2015, Volume: 52, Issue:3 Topics: Action Potentials; Animals; Cochlea; Disease Models, Animal; Ear Diseases; Evoked Potentials, Audito	2015
N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model. The journal of international advanced otology, 2015, Volume: 11, Issue:1 Topics: Acetylcysteine; Animals; Cochlea; Disease Models, Animal; Ear Diseases; Evoked Potentials, Auditory,	2015
Quercetine attenuates the gentamicin-induced ototoxicity in a rat model. International journal of pediatric otorhinolaryngology, 2015, Volume: 79, Issue:12 Topics: Animals; Anti-Bacterial Agents; Antioxidants; Apoptosis; Caspase 3; Caspase 9; Ear Diseases; Evoked	2015
Ototoxic effects from gentamicin ear drops. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Jul-09, Volume: 167, Issue:1 Topics: Anti-Bacterial Agents; Contraindications; Ear Diseases; Gentamicins; Humans; Instillation, Drug; Tym	2002
Topical aminoglycosides? No. The case against using these agents in chronic ear disease. Ear, nose, & throat journal, 2003, Volume: 82 Suppl 1 Topics: Administration, Topical; Aminoglycosides; Chronic Disease; Ear Diseases; Gentamicins; Humans	2003
Is gentamicin ototoxic to the fetus? Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2007, Volume: 29, Issue:2 Topics: Anti-Bacterial Agents; Ear Diseases; Female; Fetal Diseases; Gentamicins; Humans; Infant, Newborn; P	2007
Expansile properties of otowicks: an in vitro study. The Journal of laryngology and otology, 2008, Volume: 122, Issue:7 Topics: Anti-Bacterial Agents; Dexamethasone; Drug Combinations; Ear Diseases; Equipment Design; Framycetin;	2008
Iontophoresis in the treatment of ear chondritis. South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie, 1982, Volume: 20, Issue:1 Topics: Cartilage Diseases; Ear Diseases; Gentamicins; Humans; Iontophoresis	1982
Comparative ototoxicity of amikacin, gentamicin, netilmicin, and tobramycin in guinea pigs. Toxicology and applied pharmacology, 1982, Sep-15, Volume: 65, Issue:2 Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Cochlea; Ear Diseases; Elect	1982
Once-daily aminoglycoside therapy: potential ototoxicity. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:9 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Dizziness; Ear Diseases; Female; Gentamicins; Humans	1996
Apoptosis and hair cell degeneration in the vestibular sensory epithelia of the guinea pig following a gentamicin insult. Hearing research, 1997, Volume: 111, Issue:1-2 Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Size; Digoxigenin; DNA Fragmentation; Ear Diseases;	1997
[When do ear drops help, when are they harmful?]. Fortschritte der Medizin, 1999, Apr-30, Volume: 117, Issue:12 Topics: Administration, Topical; Chloramphenicol; Contraindications; Drug-Related Side Effects and Adverse R	1999
Blood-perilymph barrier and ototoxicity: an in vivo study in the rat. Acta oto-laryngologica, 2000, Volume: 120, Issue:7 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Blood; Capillary Permeability; Cisplatin; Ear	2000
[The physicians duty to inform the patient before treatment with gentamicin]. MMW, Munchener medizinische Wochenschrift, 1977, May-27, Volume: 119, Issue:21 Topics: Ear Diseases; Gentamicins; Germany, West; Health Education; Humans; Informed Consent	1977
[Tuberculosis of the middle and external ear; a report of two cases (author's transl)]. Praxis der Pneumologie, 1977, Volume: 31, Issue:1 Topics: Adult; Deafness; Ear Diseases; Ear, External; Ear, Middle; Female; Gentamicins; Humans; Isoniazid; M	1977
Comparative ototoxicity of amikacin and gentamicin in cats. Antimicrobial agents and chemotherapy, 1977, Volume: 12, Issue:2 Topics: Acoustic Stimulation; Action Potentials; Amikacin; Animals; Behavior, Animal; Cats; Ear Diseases; Fe	1977
[Gentamicin and ototoxicity. A prospective study]. Ugeskrift for laeger, 1976, Oct-04, Volume: 138, Issue:41 Topics: Ear Diseases; Female; Gentamicins; Hearing Disorders; Humans; Male; Prospective Studies; Vestibule,	1976
Gentamicin administration via peritoneal dialysis fluid: the risk of ototoxicity. The Journal of laryngology and otology, 1991, Volume: 105, Issue:12 Topics: Audiometry, Pure-Tone; Calorimetry; Dialysis Solutions; Ear Diseases; Gentamicins; Humans; Middle Ag	1991
Advances in oto-immunology: new trends in functional pathology of the temporal bone. The Laryngoscope, 1987, Volume: 97, Issue:4 Topics: Animals; Cholesteatoma; Cochlea; Ear Diseases; Ear, Inner; Ear, Middle; Gentamicins; Guinea Pigs; Hu	1987
Progress in temporal bone histopathology. II. Immuno-technology applied to the temporal bone. Acta oto-laryngologica. Supplementum, 1985, Volume: 423 Topics: Animals; Antibodies, Monoclonal; Cholesteatoma; Ear Diseases; Gentamicins; Hair Cells, Auditory; Hum	1985
An energy-dependent step in aminoglycoside ototoxicity: prevention of gentamicin ototoxicity during reduced endolymphatic potential. Hearing research, 1985, Volume: 19, Issue:3 Topics: Aminoglycosides; Aminooxyacetic Acid; Animals; Cochlear Microphonic Potentials; Ear Diseases; Endoly	1985
Letter: Serum-gentamicin. Lancet (London, England), 1974, Dec-14, Volume: 2, Issue:7894 Topics: Ear Diseases; Gentamicins; Humans; Respiratory Tract Infections	1974
[Gentamicin and auricular toxicity]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1969, Volume: 86, Issue:9 Topics: Adult; Animals; Audiometry; Deafness; Ear Diseases; Ear, Inner; Female; Gentamicins; Guinea Pigs; Hi	1969
Vertigo and its treatment. Drugs, 1974, Volume: 7, Issue:3 Topics: Air Pressure; Anxiety; Brain Diseases; Cardiovascular Diseases; Cervical Vertebrae; Ear Diseases; Et	1974
Cochlear and vestibular gentamicin toxicity. A clinical study of systemic and topical usage. Archives of otolaryngology (Chicago, Ill. : 1960), 1974, Volume: 100, Issue:5 Topics: Administration, Topical; Cochlea; Ear Diseases; Gentamicins; Hearing Disorders; Hearing Tests; Human	1974
Bacteriuria again. British medical journal, 1971, May-29, Volume: 2, Issue:5760 Topics: Bacteriuria; Ear Diseases; Gentamicins; Humans; Urea	1971