Page last updated: 2024-10-27

gentamicin and Drug-Induced Cochlear Toxicity

gentamicin has been researched along with Drug-Induced Cochlear Toxicity in 30 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

ExcerptRelevanceReference
"The study intended to explore acupuncture's protective effects and mechanism of treatment in addressing ototoxicity induced by gentamicin (GM) in aged mice."9.51Acupuncture Attenuates Ototoxicity Induced by Gentamicin in Mice. ( Cao, L; Guan, N; Han, M; Tang, Y; Yu, Y, 2022)
"To emphasize the risk of gentamicin ototoxicity and suggest alternative antibiotics in penicillin-allergic patients undergoing surgery."8.31Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis. ( Gubbels, SP; Kalmanson, OA; Kiser, TH; McLoughlin, KC, 2023)
" However, the potential protective effects of taxifolin against gentamicin-induced ototoxicity have not been confirmed."8.12Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells. ( Hsu, CJ; Lin, CC; Lin, HY; Lin, JN; Tseng, GF; Wang, JS; Wen, YH; Wu, HP; Yu, SH, 2022)
"Gentamicin (GM) is a commonly used antibiotic, and ototoxicity is one of its side effects."8.02Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway. ( Li, G; Niu, P; Pan, C; Sun, J; Sun, Y; Tang, X; Wang, S, 2021)
"The first identified reference of quinine ototoxicity was from 1824."8.02Quinine in Otology and Neurotology: Ototoxicity and Historic Role in Therapy. ( Dias-Silva, N; Miguéis, J; Pita, JR; Semedo, MG, 2021)
"We aimed to confirm the synergistic ototoxicity of combined gentamicin and low-dose irradiation treatment and identify the underlying molecular mechanisms using an in vitro model."7.96Synergistic Ototoxicity of Gentamicin and Low-Dose Irradiation: Molecular Basis and Clinical Significance. ( Low, WK; Tan, MGK; Teng, SW, 2020)
"Gentamicin-induced cochlear hair cell ototoxicity, such as oxidative stress and apoptosis, could be attenuated by mouse inner ear stem cells (IESCs)."7.96Exosomes derived from mouse inner ear stem cells attenuate gentamicin-induced ototoxicity in vitro through the miR-182-5p/FOXO3 axis. ( Cai, C; Hu, P; Lai, R; Wang, Q; Wu, W, 2020)
"Gentamicin is a widely used antibiotic for the treatment of gram-negative bacterial infections; however, its use often results in significant and permanent hearing loss."7.91Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K-Akt pathway. ( Bodmer, D; Horvath, L; Kucharava, K; Petkovic, V; Sekulic-Jablanovic, M, 2019)
"Gentamicin can lead to cochlear hair cells associated ototoxicity by inducing apoptosis and oxidative stress, which can be alleviated by baicalin, one flavonoid extracted from the root of Scutellaria baicalensis."7.91Baicalin attenuates gentamicin-induced cochlear hair cell ototoxicity. ( Yu, J; Zhang, X, 2019)
"It is known that ototoxicity is the main cause of toxicity induced by aminoglycoside antibiotics."5.72Salicylate attenuates gentamicin-induced ototoxicity and facilitates the recovery in the basilar papilla of the lizard Podarcis siculus. ( Avallone, B; Fogliano, C; Motta, CM, 2022)
" In the present study, we compared the in vivo toxic effects of three aminoglycosides, gentamicin, amikacin, and etimicin, in zebrafish embryos."5.62A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos. ( Chen, D; Han, Y; Jiang, H; Jing, L; Li, R; Qian, X; Shao, W; Yin, Y; Zhong, D, 2021)
"Calcium dobesilate is a pharmacologically active agent used to treat many disorders due to its vasoprotective and antioxidant effects."5.56Does Calcium Dobesilate Have Therapeutic Effect on Gentamicin-induced Cochlear Nerve Ototoxicity? An Experimental Study. ( Altunay, ZÖ; Ataş, A; Çınar, Z; Edizer, DT; Gül, M; Yiğit, Ö, 2020)
"The study intended to explore acupuncture's protective effects and mechanism of treatment in addressing ototoxicity induced by gentamicin (GM) in aged mice."5.51Acupuncture Attenuates Ototoxicity Induced by Gentamicin in Mice. ( Cao, L; Guan, N; Han, M; Tang, Y; Yu, Y, 2022)
"The ototoxicity of gentamicin and cisplatin can be evaluated with a Schwann cell model to screen for otoprotective agents that can be encapsulated into poly (lactic-co-glycolic acid) (PLGA) microparticles for drug delivery to the inner ear."4.31Designing a Prolonged Method of Therapeutic Delivery to Support Rehabilitation From Ototoxic Damage in a Schwann Cell Model. ( Echanique, KA; Hoffman, LF; Hong, MK; Kita, AE, 2023)
"To emphasize the risk of gentamicin ototoxicity and suggest alternative antibiotics in penicillin-allergic patients undergoing surgery."4.31Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis. ( Gubbels, SP; Kalmanson, OA; Kiser, TH; McLoughlin, KC, 2023)
" However, the potential protective effects of taxifolin against gentamicin-induced ototoxicity have not been confirmed."4.12Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells. ( Hsu, CJ; Lin, CC; Lin, HY; Lin, JN; Tseng, GF; Wang, JS; Wen, YH; Wu, HP; Yu, SH, 2022)
"Gentamicin is a widely used aminoglycoside with ototoxicity as a known adverse effect."4.12A Prospective Study on the Vestibular Toxicity of Gentamicin in a Clinical Setting. ( Chatterton, S; Cremer, PD; Kotsiou, G; Migliaccio, AA; Satyan, H; Todd, CJ; Wang, C, 2022)
"Gentamicin (GM) is a commonly used antibiotic, and ototoxicity is one of its side effects."4.02Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway. ( Li, G; Niu, P; Pan, C; Sun, J; Sun, Y; Tang, X; Wang, S, 2021)
"The first identified reference of quinine ototoxicity was from 1824."4.02Quinine in Otology and Neurotology: Ototoxicity and Historic Role in Therapy. ( Dias-Silva, N; Miguéis, J; Pita, JR; Semedo, MG, 2021)
"We aimed to confirm the synergistic ototoxicity of combined gentamicin and low-dose irradiation treatment and identify the underlying molecular mechanisms using an in vitro model."3.96Synergistic Ototoxicity of Gentamicin and Low-Dose Irradiation: Molecular Basis and Clinical Significance. ( Low, WK; Tan, MGK; Teng, SW, 2020)
"Gentamicin-induced cochlear hair cell ototoxicity, such as oxidative stress and apoptosis, could be attenuated by mouse inner ear stem cells (IESCs)."3.96Exosomes derived from mouse inner ear stem cells attenuate gentamicin-induced ototoxicity in vitro through the miR-182-5p/FOXO3 axis. ( Cai, C; Hu, P; Lai, R; Wang, Q; Wu, W, 2020)
"Gentamicin has proven to be a very successful treatment for bacterial infection, but it also can cause adverse effects, especially ototoxicity, which is irreversible."3.96Saliva versus Plasma Therapeutic Drug Monitoring of Gentamicin in Jordanian Preterm Infants. Development of a Physiologically-Based Pharmacokinetic (PBPK) Model and Validation of Class II Drugs of Salivary Excretion Classification System. ( Al-Adham, I; Al-Ghazawi, A; Alsmadi, M; Aqrabawi, H; Awaysheh, F; Bani-Domi, R; Hamadi, S; Idkaidek, N; Rabayah, A, 2020)
"Gentamicin is a widely used antibiotic for the treatment of gram-negative bacterial infections; however, its use often results in significant and permanent hearing loss."3.91Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K-Akt pathway. ( Bodmer, D; Horvath, L; Kucharava, K; Petkovic, V; Sekulic-Jablanovic, M, 2019)
"Gentamicin can lead to cochlear hair cells associated ototoxicity by inducing apoptosis and oxidative stress, which can be alleviated by baicalin, one flavonoid extracted from the root of Scutellaria baicalensis."3.91Baicalin attenuates gentamicin-induced cochlear hair cell ototoxicity. ( Yu, J; Zhang, X, 2019)
"It is known that ototoxicity is the main cause of toxicity induced by aminoglycoside antibiotics."1.72Salicylate attenuates gentamicin-induced ototoxicity and facilitates the recovery in the basilar papilla of the lizard Podarcis siculus. ( Avallone, B; Fogliano, C; Motta, CM, 2022)
" In the present study, we compared the in vivo toxic effects of three aminoglycosides, gentamicin, amikacin, and etimicin, in zebrafish embryos."1.62A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos. ( Chen, D; Han, Y; Jiang, H; Jing, L; Li, R; Qian, X; Shao, W; Yin, Y; Zhong, D, 2021)
"Calcium dobesilate is a pharmacologically active agent used to treat many disorders due to its vasoprotective and antioxidant effects."1.56Does Calcium Dobesilate Have Therapeutic Effect on Gentamicin-induced Cochlear Nerve Ototoxicity? An Experimental Study. ( Altunay, ZÖ; Ataş, A; Çınar, Z; Edizer, DT; Gül, M; Yiğit, Ö, 2020)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (20.00)24.3611
2020's24 (80.00)2.80

Authors

AuthorsStudies
Niu, P1
Sun, Y1
Wang, S1
Li, G1
Tang, X1
Sun, J2
Pan, C1
Yu, Y1
Cao, L1
Guan, N1
Tang, Y1
Han, M1
Lin, JN3
Wang, JS1
Lin, CC2
Lin, HY2
Yu, SH2
Wen, YH3
Tseng, GF3
Hsu, CJ3
Wu, HP3
Hwang, CF1
Kmietowicz, Z1
Abd-Elhakim, YM1
Abdel-Motal, SM1
Malhat, SM1
Mostafa, HI1
Ibrahim, WM1
Beheiry, RR1
Moselhy, AAA1
Said, EN1
Chatterton, S1
Wang, C1
Satyan, H1
Kotsiou, G1
Todd, CJ1
Migliaccio, AA1
Cremer, PD1
Fogliano, C1
Motta, CM1
Avallone, B1
Tuna, B2
Tüzemen, G2
Hong, MK1
Echanique, KA1
Hoffman, LF1
Kita, AE1
Chow, MR1
Fernandez Brillet, C1
Hageman, KN1
Roberts, DC1
Ayiotis, AI1
Haque, RM1
Della Santina, CC1
Kalmanson, OA1
McLoughlin, KC1
Kiser, TH1
Gubbels, SP1
Low, WK1
Teng, SW1
Tan, MGK1
Ding, D1
Zhang, J1
Jiang, H2
Xuan, W1
Qi, W1
Salvi, R1
Jiang, F1
Kuper, H1
Bright, T1
Qin, WZ1
Lai, R1
Cai, C1
Wu, W1
Hu, P1
Wang, Q1
Wu, RS1
Idkaidek, N1
Hamadi, S1
Bani-Domi, R1
Al-Adham, I1
Alsmadi, M1
Awaysheh, F1
Aqrabawi, H1
Al-Ghazawi, A1
Rabayah, A1
Çınar, Z1
Edizer, DT1
Yiğit, Ö1
Altunay, ZÖ1
Gül, M1
Ataş, A1
Shao, W1
Zhong, D1
Han, Y1
Yin, Y1
Li, R1
Qian, X1
Chen, D1
Jing, L1
Semedo, MG1
Dias-Silva, N1
Miguéis, J1
Pita, JR1
Gao, D1
Wu, H1
Jie, H1
Liang, M1
Yu, D1
Feng, Y1
Balasubramanian, K1
Zheng, G1
Yang, J1
He, J1
Kenyon, EJ1
Kirkwood, NK1
Kitcher, SR1
Goodyear, RJ1
Derudas, M1
Cantillon, DM1
Baxendale, S1
de la Vega de León, A1
Mahieu, VN1
Osgood, RT1
Wilson, CD1
Bull, JC1
Waddell, SJ1
Whitfield, TT1
Ward, SE1
Kros, CJ1
Richardson, GP1
Giurdanella, G1
Montalbano, G1
Gennuso, F1
Brancati, S1
Lo Furno, D1
Augello, A1
Bucolo, C1
Drago, F1
Salomone, S1
Korkmaz, S1
Ceylan, ME1
Ceylan, G1
Dalgıç, A1
İnan, S1
Olgun, L1
Özüer, MZ1
Kucharava, K1
Sekulic-Jablanovic, M1
Horvath, L1
Bodmer, D1
Petkovic, V1
Ishikawa, M1
García-Mateo, N1
Čusak, A1
López-Hernández, I1
Fernández-Martínez, M1
Müller, M1
Rüttiger, L1
Singer, W1
Löwenheim, H1
Kosec, G1
Fujs, Š1
Martínez-Martínez, L1
Schimmang, T1
Petković, H1
Knipper, M1
Durán-Alonso, MB1
Zhang, X1
Yu, J1
Werner, M1
Van De Water, TR1
Stenlund, H1
Berggren, D1
Smyth, D1
Mossman, S1
Weatherall, M1
Jolliffe, E1
Joshi, P1
Taylor, J1
Thorne, K1
Watson, E1
Leadbetter, R1
Mossman, B1
Moss, T1
Todd, N1
Schneider, E1

Trials

1 trial available for gentamicin and Drug-Induced Cochlear Toxicity

ArticleYear
Acupuncture Attenuates Ototoxicity Induced by Gentamicin in Mice.
    Alternative therapies in health and medicine, 2022, Volume: 28, Issue:2

    Topics: Acupuncture Therapy; Animals; Cochlea; Gentamicins; Hair Cells, Auditory; Male; Mice; Ototoxicity

2022

Other Studies

29 other studies available for gentamicin and Drug-Induced Cochlear Toxicity

ArticleYear
Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway.
    Molecular medicine reports, 2021, Volume: 24, Issue:6

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cell Survival; Gentamicins; Ha

2021
Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells.
    Journal of the Chinese Medical Association : JCMA, 2022, 05-01, Volume: 85, Issue:5

    Topics: Animals; Apoptosis; Down-Regulation; Gentamicins; Mice; Ototoxicity; Quercetin; Reactive Oxygen Spec

2022
2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling.
    International journal of molecular medicine, 2022, Volume: 49, Issue:5

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Gentamicins; Glucosides; Mice; Ototoxicity; Stilb

2022
Neonatal units in Manchester roll out genetic test for gentamicin ototoxicity.
    BMJ (Clinical research ed.), 2022, 04-04, Volume: 377

    Topics: Gentamicins; Humans; Infant, Newborn; Ototoxicity

2022
Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:60

    Topics: Animals; Apoptosis; Caspase 3; Curcumin; Gentamicins; NF-kappa B; Ototoxicity; Rats; Sodium Salicyla

2022
A Prospective Study on the Vestibular Toxicity of Gentamicin in a Clinical Setting.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2022, 10-01, Volume: 43, Issue:9

    Topics: Aminoglycosides; Gentamicins; Head Impulse Test; Humans; Ototoxicity; Prospective Studies; Reflex, V

2022
Salicylate attenuates gentamicin-induced ototoxicity and facilitates the recovery in the basilar papilla of the lizard Podarcis siculus.
    Neurotoxicology, 2022, Volume: 93

    Topics: Animals; Anti-Bacterial Agents; Bromodeoxyuridine; Gentamicins; Lizards; Mammals; Organ of Corti; Ot

2022
Protective effects of nigella sativa oil against gentamicin-induced ototoxicity in rats: A dose-ranging study.
    International journal of pediatric otorhinolaryngology, 2023, Volume: 164

    Topics: Animals; Anti-Bacterial Agents; Gentamicins; Male; Ototoxicity; Plant Oils; Rats; Rats, Sprague-Dawl

2023
Protective effects of nigella sativa oil against gentamicin-induced ototoxicity in rats: A dose-ranging study.
    International journal of pediatric otorhinolaryngology, 2023, Volume: 164

    Topics: Animals; Anti-Bacterial Agents; Gentamicins; Male; Ototoxicity; Plant Oils; Rats; Rats, Sprague-Dawl

2023
Protective effects of nigella sativa oil against gentamicin-induced ototoxicity in rats: A dose-ranging study.
    International journal of pediatric otorhinolaryngology, 2023, Volume: 164

    Topics: Animals; Anti-Bacterial Agents; Gentamicins; Male; Ototoxicity; Plant Oils; Rats; Rats, Sprague-Dawl

2023
Protective effects of nigella sativa oil against gentamicin-induced ototoxicity in rats: A dose-ranging study.
    International journal of pediatric otorhinolaryngology, 2023, Volume: 164

    Topics: Animals; Anti-Bacterial Agents; Gentamicins; Male; Ototoxicity; Plant Oils; Rats; Rats, Sprague-Dawl

2023
Designing a Prolonged Method of Therapeutic Delivery to Support Rehabilitation From Ototoxic Damage in a Schwann Cell Model.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2023, 04-01, Volume: 44, Issue:4

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Cisplatin; Gentamicins; Ototoxicity; Rats; Schwann C

2023
Binocular 3-D otolith-ocular reflexes: responses of chinchillas to natural and prosthetic stimulation after ototoxic injury and vestibular implantation.
    Journal of neurophysiology, 2023, 05-01, Volume: 129, Issue:5

    Topics: Animals; Chinchilla; Gentamicins; Otolithic Membrane; Ototoxicity; Reflex, Vestibulo-Ocular; Vestibu

2023
Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis.
    The Annals of otology, rhinology, and laryngology, 2023, Volume: 132, Issue:12

    Topics: Anti-Bacterial Agents; Female; Gentamicins; Humans; Hypersensitivity; Ototoxicity; Penicillins

2023
Synergistic Ototoxicity of Gentamicin and Low-Dose Irradiation: Molecular Basis and Clinical Significance.
    Audiology & neuro-otology, 2020, Volume: 25, Issue:3

    Topics: Animals; Apoptosis; Cell Line; Cochlea; Gentamicins; Mice; Ototoxicity; Phosphorylation; Radiotherap

2020
Some Ototoxic Drugs Destroy Cochlear Support Cells Before Damaging Sensory Hair Cells.
    Neurotoxicity research, 2020, Volume: 37, Issue:3

    Topics: Animals; Apoptosis; Cadmium; Caspases; Cisplatin; Cochlea; Extracellular Matrix; Gentamicins; Hair C

2020
Etiology of Childhood Bilateral Sensorineural Hearing Loss in Shandong Province, China.
    American journal of audiology, 2020, Jun-08, Volume: 29, Issue:2

    Topics: Adolescent; Anti-Bacterial Agents; Asphyxia Neonatorum; Audiometry; Child; Child, Preschool; China;

2020
Exosomes derived from mouse inner ear stem cells attenuate gentamicin-induced ototoxicity in vitro through the miR-182-5p/FOXO3 axis.
    Journal of tissue engineering and regenerative medicine, 2020, Volume: 14, Issue:8

    Topics: Animals; Ear, Inner; Exosomes; Forkhead Box Protein O3; Gentamicins; Mice; MicroRNAs; Ototoxicity; S

2020
Otoprotective Effect of 2,3,4',5-Tetrahydroxystilbene-2-
    Molecules (Basel, Switzerland), 2020, Jul-06, Volume: 25, Issue:13

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cell Survival; Fallopia multiflora; Ge

2020
Saliva versus Plasma Therapeutic Drug Monitoring of Gentamicin in Jordanian Preterm Infants. Development of a Physiologically-Based Pharmacokinetic (PBPK) Model and Validation of Class II Drugs of Salivary Excretion Classification System.
    Drug research, 2020, Volume: 70, Issue:10

    Topics: Bacterial Infections; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug D

2020
Does Calcium Dobesilate Have Therapeutic Effect on Gentamicin-induced Cochlear Nerve Ototoxicity? An Experimental Study.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2020, Volume: 41, Issue:10

    Topics: Animals; Calcium Dobesilate; Cochlear Nerve; Evoked Potentials, Auditory, Brain Stem; Gentamicins; O

2020
A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos.
    Journal of applied toxicology : JAT, 2021, Volume: 41, Issue:7

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Embryo, Nonmammalian; Gentamicins; Gram-Negative Ba

2021
Quinine in Otology and Neurotology: Ototoxicity and Historic Role in Therapy.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2021, Volume: 42, Issue:1

    Topics: Gentamicins; Humans; Neurotology; Otolaryngology; Ototoxicity; Quinine

2021
XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.
    Biochemical pharmacology, 2021, Volume: 186

    Topics: Animals; Caspase 3; Caspase 9; Dose-Response Relationship, Drug; Gentamicins; Hair Cells, Auditory;

2021
Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity.
    JCI insight, 2021, 04-08, Volume: 6, Issue:7

    Topics: Aminoglycosides; Animals; Cochlea; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Female; Genta

2021
Isolation, cultivation, and characterization of primary bovine cochlear pericytes: A new in vitro model of stria vascularis.
    Journal of cellular physiology, 2019, Volume: 234, Issue:3

    Topics: Actins; Animals; Antigens; Biomarkers; Cattle; Cell Culture Techniques; Cell Survival; Cisplatin; Co

2019
Auditory and Histopathological Effects of Topical Mercurochrome Treatment in Rats with Tympanic Membrane Perforation.
    The journal of international advanced otology, 2019, Volume: 15, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cochlea; Female; Gentamicins; Hearing; Merb

2019
Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K-Akt pathway.
    Cell death & disease, 2019, 02-06, Volume: 10, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Female; Gentamicins; Hair Cells, Auditory; Hearing Loss; Hormones; H

2019
Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use.
    Scientific reports, 2019, 02-20, Volume: 9, Issue:1

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cell Line; Drug Resistance,

2019
Baicalin attenuates gentamicin-induced cochlear hair cell ototoxicity.
    Journal of applied toxicology : JAT, 2019, Volume: 39, Issue:8

    Topics: Anti-Bacterial Agents; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Dose-Response Relations

2019
Ultrastructural Characterization of Stem Cell-Derived Replacement Vestibular Hair Cells Within Ototoxin-Damaged Rat Utricle Explants.
    Anatomical record (Hoboken, N.J. : 2007), 2020, Volume: 303, Issue:3

    Topics: Animals; Cell Transdifferentiation; Gentamicins; Hair Cells, Vestibular; Ototoxicity; Rats; Rats, Wi

2020
Gentamicin vestibulotoxicity with modern systemic dosing regimens: a prospective study using video-oculography.
    Acta oto-laryngologica, 2019, Volume: 139, Issue:9

    Topics: Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genta

2019