gentamicin has been researched along with Disease Models, Animal in 476 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the urinary microRNA expression profile in a gentamicin-induced acute kidney injury canine model using RNA sequencing." | 8.02 | Urinary microRNAs miR-15b and miR-30a as novel noninvasive biomarkers for gentamicin-induced acute kidney injury. ( Chen, XG; Cheng, GL; Li, B; Miao, YF; Qu, Z; Sun, B; Yang, YW; Zhou, XB, 2021) |
| "Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed." | 7.88 | Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter? ( Duan, M; Marques, P; Perez-Fernandez, N; Spratley, J, 2018) |
| " This study was aimed at evaluating the effect of rutin on oxidative stress, inflammation, apoptosis, and autophagy in gentamicin-induced nephrotoxicity in rats." | 7.81 | Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats. ( Aktas, E; Benzer, F; Hanedan, B; Kandemir, FM; Kilic, K; Kirbas, A; Ozkaraca, M; Yildirim, BA, 2015) |
| "Gentamicin may cause acute kidney injury." | 7.81 | Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models. ( Bai, XY; Cai, G; Chen, X; Cui, J; Ding, R; Hong, Q; Sun, X, 2015) |
| " To explore the role of Tbx1 in acute kidney injury (AKI) and the underlying mechanism, we detected the expression of Tbx1 and components of transforming growth factor-beta (TGF-β) signaling pathways including TGF-β, phosphorylated Smad2/3 (p-Smad2/3) and phosphorylated Smad1/5/8 (p-Smad1/5/8) in kidney tissues derived from a rat model for AKI induced by gentamicin (GM)." | 7.80 | Increased Tbx1 expression may play a role via TGFβ-Smad2/3 signaling pathway in acute kidney injury induced by gentamicin. ( Huang, Y; Jiang, H; Li, L; Li, Y; Li-Ling, J; Niu, Z; Qiu, G; Sun, K, 2014) |
| "The aim of this study was to establish a murine protothecal mastitis model and to evaluate the treatment efficiency of gentamicin." | 7.79 | Treatment with gentamicin on a murine model of protothecal mastitis. ( Chang, R; Han, B; Liu, G; Liu, Y; Su, J; Yang, Q; Zheng, B, 2013) |
| "We evaluated the potential of an injectable degradable polymer-poly(sebacic-co-ricinoleic-ester-anhydride) containing gentamicin for the treatment of osteomyelitis." | 7.74 | Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin. ( Brin, YS; Domb, AJ; Golenser, J; Maoz, G; Mizrahi, B; Nyska, A; Nyska, M; Peddada, S; Tuvia, S, 2008) |
| "The proven rat model for Staphylococcus aureus-induced osteomyelitis was used to compare the results of monotherapy with cefazolin, gentamicin-PMMA beads, or gentamicin-containing collagen sponge with the combination of local and systemic antibiotic treatment." | 7.73 | Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats. ( Heymann, H; Mendel, V; Scholz, HC; Simanowski, HJ, 2005) |
| "The therapeutic efficacy of an antimicrobial peptide, human lactoferrin 1-11 (hLF1-11), was investigated in a model of chronic methicillin-resistant Staphylococcus aureus (MRSA) (gentamicin susceptible) osteomyelitis in rabbits." | 7.73 | Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model. ( Faber, C; Joosten, U; Lyaruu, DM; Stallmann, HP; van Nieuw Amerongen, A; von Eiff, C; Wuisman, PI, 2005) |
| "We utilized a newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC) to investigate the effects of omeprazole and/or gentamicin on the formation of free oxygen radicals (FOR) and bowel histopathology." | 7.73 | Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats. ( Aritürk, E; Aydin, BK; Aydin, O; Bernay, F; Biçakçi, U; Eren, Z; Rizalar, R; Tander, B, 2005) |
| "To evaluate the efficacy of iontophoresis using a hydrogel probe containing gentamicin for the treatment of Pseudomonas keratitis in the rabbit cornea." | 7.73 | Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels. ( Domb, A; Eljarrat-Binstock, E; Frucht-Pery, J; Mechoulam, H; Raiskup, F; Shapiro, M, 2006) |
| "To study the influence of gentamicin-containing sponges on the healing of colonic anastomoses in a rat model of peritonitis." | 7.70 | Effect of gentamicin-containing sponges on the healing of colonic anastomoses in a rat model of peritonitis. ( Eyskens, EJ; Hendriks, JM; Ieven, M; Lauwers, PR; Vaneerdeweg, W, 2000) |
| "The pharmacokinetics and efficacy of isepamicin were compared with those of amikacin and gentamicin in a rabbit model of endocarditis due to Klebsiella pneumoniae CF104 producing beta-lactamase TEM-3 and aminoglycoside acetyltransferase AAC(6')-IV." | 7.69 | Activity of isepamicin and selection of permeability mutants to beta-lactams during aminoglycoside therapy of experimental endocarditis due to Klebsiella pneumoniae CF104 producing an aminoglycoside acetyltransferase 6' modifying enzyme and a TEM-3 beta-l ( Carbon, C; Farinotti, R; Goldstein, F; Gutmann, L; Mainardi, JL; Mohler, J; Zhou, XY, 1994) |
| "Activity of aminoglycosides such as gentamicin, sisomicin and amikacin against plague microbe strains of natural origin was studied in vitro." | 7.68 | [Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague]. ( Bugaeva, OK; Kasatkina, IV; Makarovskaia, LN; Shcherbaniuk, AI, 1992) |
| "An experimental Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats was used to study the impact of the duration of infection on the bactericidal activity of ceftazidime, gentamicin and ciprofloxacin." | 7.68 | Impact of the duration of infection on the activity of ceftazidime, gentamicin and ciprofloxacin in Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats. ( Bakker-Woudenberg, IA; Michel, MF; Roosendaal, R; van den Berghe-van Raffe, M; Vink-van den Berg, JC, 1991) |
| "In a rodent model of Escherichia coli brain abscess, the natural history of the infection was studied and the influence of a glucocorticoid (dexamethasone) and an antibiotic (gentamicin) on the development of brain abscess and the survival of abscess-bearing animals was evaluated." | 7.67 | Effect of gentamicin and dexamethasone on the natural history of the rat Escherichia coli brain abscess model with histopathological correlation. ( Blank, NK; Lawrence, MS; Neuwelt, EA, 1984) |
| "The pharmacokinetics and therapeutic efficacy of gentamicin were investigated in an experimental pleural empyema rabbit model." | 7.67 | Pharmacokinetics and therapeutic efficacy of gentamicin in an experimental pleural empyema rabbit model. ( Meyerovitch, J; Rubinstein, E; Shohet, I; Yellin, A, 1987) |
| "Trimethoprim-sulfadiazine and gentamicin sulfate decreased early mortality in an established model of fibrinous peritonitis in the rat." | 7.67 | Efficacies of trimethoprim-sulfadiazine and gentamicin sulfate in the treatment of fibrinous peritonitis in rats. ( Benson, CE; Emms, SG, 1987) |
| "The therapeutic efficacy of ceftriaxone and gentamicin was investigated in a foreign body induced abscess model in the rat by implanting a dialysis tube contaminated with Klebsiella pneumoniae into the subcutaneous tissue." | 7.66 | Efficacy of ceftriaxone and gentamicin in an abscess model. ( Mark, Z; Pritsch, M; Rubinstein, E; Spicehandler, J, 1982) |
| "Moxalactam (LY127935) is a 1-oxa-beta-lactam which was active in vitro against the majority of 128 strains of gram-negative enteric bacilli isolated from meningitis in neonates." | 7.66 | Pharmacokinetics and bacteriological efficacy of moxalactam (LY127935), netilmicin, and ampicillin in experimental gram-negative enteric bacillary meningitis. ( Loock, CA; McCracken, GH; Schaad, UB; Thomas, ML, 1980) |
| "In a quantitative model of experimental Pseudomonas aeruginosa keratitis in guinea pigs, topical solutions of amikacin, gentamicin and tobramycin were equally effective." | 7.66 | Relative efficacy of the topical use of amikacin, gentamicin and tobramycin in experimental Pseudomonas keratitis. ( Davis, SD; Hyndiuk, RA; Sarff, LD, 1980) |
| "The pharmacokinetics and therapeutic efficacy of gentamicin and cefsulodin were studied in an abscess model in the rat induced by Pseudomonas aeruginosa and a foreign body." | 7.66 | Gentamicin and cefsulodin efficacy in a rat abscess model. ( Dreznik, Z; Mark, Z; Rubinstein, E, 1982) |
| "Antibiotic therapy of methicillin-resistant Staphylococcus epidermidis endocarditis was investigated with the rabbit endocarditis model." | 7.66 | Therapy of methicillin-resistant Staphylococcus epidermidis experimental endocarditis. ( Lowy, FD; Steigbigel, NH; Wexler, MA, 1982) |
| "Rats with obstructive pyelonephritis due to Escherichia coli were treated for different intervals with ampicillin and gentamicin either alone or in combination." | 7.66 | Synergism of ampicillin and gentamicin against obstructive pyelonephritis due to Escherichia coli in rats. ( Braude, AI; Glauser, MP; Lyons, JM, 1979) |
| "Using a rabbit sterile peritonitis model, we compared the penetration of intravenously administered amikacin, gentamicin, and penicillin G into peritoneal exudate." | 7.65 | Comparative penetration of amikacin, gentamicin, and penicillin g into exudate fluid in experimental sterile peritonitis. ( MacGregor, RR, 1977) |
| "Levels of rifampin, gentamicin, sisomicin, and cephalothin in normal and osteomyelitic rabbit bones were measured, and the efficacy of these drugs in the treatment of osteomyelitis was evaluated." | 7.65 | Experimental osteomyelitis. IV. Therapeutic trials with rifampin alone and in combination with gentamicin, sisomicin, and cephalothin. ( Norden, CW, 1975) |
| "Gentamicin is an important broad-spectrum antibiotic; nevertheless, it exhibits serious nephrotoxic adverse effects." | 5.62 | HPLC-ESI/MS profiling, phytoconstituent isolation and evaluation of renal function, oxidative stress and inflammation in gentamicin-induced nephrotoxicity in rats of Ficus spragueana Mildbr. & Burret. ( Aboutabl, ME; Masoud, MA; Nassar, MI; Raslan, MA; Taher, RF, 2021) |
| "Gentamicin is an aminoglycoside antibiotic commonly administrated to patients with Gram-negative infections." | 5.56 | Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity. ( Janfeshan, S; Karimi, Z; Pakfetrat, Z; Roozbeh, J, 2020) |
| "Mice treated with gentamicin for 7 days developed AKI, and programmed cell death pathways were examined using pharmacologic inhibitors and in RIPK3-deficient mice." | 5.56 | Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct. ( Capen, DE; Huang, H; Huang, M; Ji, H; Jin, WW; Lu, HAJ; Păunescu, TG; Xia, Y; Yuan, J, 2020) |
| "Current drug candidates used to treat hearing loss commonly have low efficacy." | 5.48 | Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss. ( Gao, H; Hou, S; Kuang, X; Liu, H; Wang, Z; Yang, Y; Zhou, S, 2018) |
| " In the LPSIL+GE group relative to C+GE, the half-life (t(1/2)) was 79% higher (p<0." | 5.38 | A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2. ( Chládek, J; Krs, O; Martinkova, J; Senkerik, M; Slizova, D; Springer, D; Studena, S, 2012) |
| " Toxicity is dose related, but some patients may still develop hearing loss even under safe dosage." | 5.37 | Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway. ( Hsu, CJ; Kao, MC; Lai, CH; Lin, CD; Lin, CW; Lin, CY; Tang, CH; Tsai, MH; Wei, IH, 2011) |
| "Gentamicin level was also measured inside the ceramic implant." | 5.30 | [Tricalcium phosphate, an antibiotic carrier: a study focused on experimental osteomyelitis in rabbits]. ( Cathelineau, G; Lambotte, JC; Lancien, G; Langlais, F; Minet, J; Thomazeau, H, 1998) |
| "Pseudomonas otitis externa is one of the most common infections treated by otolaryngologists." | 5.28 | Gentamicin iontophoresis in the treatment of bacterial otitis externa in the guinea pig model. ( Estrem, SA; King, DM, 1990) |
| " Moreover, acute pneumonia obtained by BhvKp with intranasal method, was characterized in terms of histopathology of pulmonary lesions, biomarkers of inflammation level, leukocytes cells infiltration extent in mice, and was assessed treatment of them with PSKP16 multiplicity of infection (MOI: 10), either individually or in combination with gentamicin." | 4.31 | Characterization of novel bacteriophage PSKP16 and its therapeutic potential against β-lactamase and biofilm producer strain of K2-Hypervirulent Klebsiella pneumoniae pneumonia infection in mice model. ( Bakht, M; Foroughi, F; Javadi, A; Marashi, SMA; Nikkhahi, F; Rahimi, S, 2023) |
| " We investigated the urinary microRNA expression profile in a gentamicin-induced acute kidney injury canine model using RNA sequencing." | 4.02 | Urinary microRNAs miR-15b and miR-30a as novel noninvasive biomarkers for gentamicin-induced acute kidney injury. ( Chen, XG; Cheng, GL; Li, B; Miao, YF; Qu, Z; Sun, B; Yang, YW; Zhou, XB, 2021) |
| " Three models of experimental AKI were undertaken in adult male Wistar rats; renal ischemia-reperfusion injury (IRI) and gentamicin (G) and cisplatin (Cisp) nephrotoxicity." | 3.96 | Impaired Tubular Reabsorption Is the Main Mechanism Explaining Increases in Urinary NGAL Excretion Following Acute Kidney Injury in Rats. ( Blanco-Gozalo, V; Docherty, NG; López-Hernández, FJ; López-Novoa, JM; Martínez-Salgado, C; Montero-Gómez, MJ; Morales, AI; Prieto-García, L; Quiros, Y; Sancho-Martínez, SM, 2020) |
| " We studied the uptake of gentamicin as a tracer substance administered IO following adrenaline administration in hemorrhagic shock and in cardiac arrest." | 3.91 | The effect of hemorrhagic shock and intraosseous adrenaline injection on the delivery of a subsequently administered drug - an experimental study. ( Eriksson, M; Larsson, A; Lipcsey, M; Strandberg, G, 2019) |
| "Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed." | 3.88 | Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter? ( Duan, M; Marques, P; Perez-Fernandez, N; Spratley, J, 2018) |
| " This study was aimed at evaluating the effect of rutin on oxidative stress, inflammation, apoptosis, and autophagy in gentamicin-induced nephrotoxicity in rats." | 3.81 | Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats. ( Aktas, E; Benzer, F; Hanedan, B; Kandemir, FM; Kilic, K; Kirbas, A; Ozkaraca, M; Yildirim, BA, 2015) |
| "Rhodococcus equi, a facultative intracellular pathogen and an important cause of pneumonia in foals, is highly susceptible to killing by gentamicin in vitro." | 3.81 | Efficacy of liposomal gentamicin against Rhodococcus equi in a mouse infection model and colocalization with R. equi in equine alveolar macrophages. ( Arnold, RD; Berghaus, LJ; Burton, AJ; Giguère, S; Hondalus, MK, 2015) |
| "Gentamicin may cause acute kidney injury." | 3.81 | Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models. ( Bai, XY; Cai, G; Chen, X; Cui, J; Ding, R; Hong, Q; Sun, X, 2015) |
| "The objective of the present study was to examine the changes in the expression profile of certain genes in rat model of gentamicin-induced acute kidney injury (AKI) and to see whether time period and routes of administration affect their expression levels." | 3.81 | Transcription profile of genes affected in response to pathological changes in drug-induced rat model of acute kidney injury. ( Alam, G; Ali, A; Begum, S; Habib, R; Kabir, N; Khan, I; Salim, A; Waseem, M, 2015) |
| "To evaluate the efficacy of corneal collagen cross-linking (CXL) with photoactivated riboflavin (PACK-CXL) as primary therapy for Staphylococcus aureus-induced corneal ulcers in a rabbit model." | 3.81 | Efficacy of Primary Collagen Cross-Linking with Photoactivated Chromophore (PACK-CXL) for the Treatment of Staphylococcus aureus-Induced Corneal Ulcers. ( Bahar, I; Gal-Or, O; Pillar, S; Rock, O; Tal, K; Zahavi, A, 2015) |
| "To explore the pattern of uptake of gentamicin into IHCs, as well as its possible contribution to hearing loss." | 3.80 | Dynamic distribution of ototoxic gentamicin entry into inner hair cells of mice. ( Hou, Z; Ji, F; Liu, K; Shi, C; Shi, L; Sun, Y; Wang, X; Xu, Y; Yang, S, 2014) |
| " To explore the role of Tbx1 in acute kidney injury (AKI) and the underlying mechanism, we detected the expression of Tbx1 and components of transforming growth factor-beta (TGF-β) signaling pathways including TGF-β, phosphorylated Smad2/3 (p-Smad2/3) and phosphorylated Smad1/5/8 (p-Smad1/5/8) in kidney tissues derived from a rat model for AKI induced by gentamicin (GM)." | 3.80 | Increased Tbx1 expression may play a role via TGFβ-Smad2/3 signaling pathway in acute kidney injury induced by gentamicin. ( Huang, Y; Jiang, H; Li, L; Li, Y; Li-Ling, J; Niu, Z; Qiu, G; Sun, K, 2014) |
| " In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis." | 3.80 | Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. ( Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ, 2014) |
| "The aim of this study was to establish a murine protothecal mastitis model and to evaluate the treatment efficiency of gentamicin." | 3.79 | Treatment with gentamicin on a murine model of protothecal mastitis. ( Chang, R; Han, B; Liu, G; Liu, Y; Su, J; Yang, Q; Zheng, B, 2013) |
| "Heme oxygenase-1 (HO-1) and its metabolic by-product, carbon monoxide (CO), protect against intestinal inflammation in experimental models of colitis, but little is known about their intestinal immune mechanisms." | 3.79 | Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. ( Borst, LB; Hansen, JJ; Kobayashi, T; Mackey, LC; Maharshak, N; Moeser, AJ; Onyiah, JC; Otterbein, LE; Plevy, SE; Rawls, JF; Russo, SM; Sheikh, SZ; Steinbach, EC, 2013) |
| " This study investigates the use of such scaffolds with gentamicin (along with bone morphogenetic protein) in an infected rat open fracture model to decrease osteomyelitis and promote fracture healing." | 3.76 | The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model. ( Chu, TM; Cox, JT; Duffy, L; Stannard, J; Stewart, RL; Volgas, D; Waites, KB, 2010) |
| "To compare the therapeutic effectiveness of a single intrastromal dose of gentamycin, tobramycin, ciprofloxacin and ofloxacin for the treatment of corneal ulcers due to Pseudomonas aeruginosa." | 3.75 | [Bacterial corneal ulcer treated with intrastromal antibiotic. Experimental model in vivo]. ( Naranjo-Tackman, R; Stangogiannis-Druya, C; Stangogiannis-Druya, E; Vanzzini, V; Villar-Kurí, J, 2009) |
| "We evaluated the potential of an injectable degradable polymer-poly(sebacic-co-ricinoleic-ester-anhydride) containing gentamicin for the treatment of osteomyelitis." | 3.74 | Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin. ( Brin, YS; Domb, AJ; Golenser, J; Maoz, G; Mizrahi, B; Nyska, A; Nyska, M; Peddada, S; Tuvia, S, 2008) |
| " Tetramethylpyrazine (TMP) is a compound purified from the rhizome of Ligusticum wallichi (Chuanxiong) and has been found to protect against ischaemia-reperfusion injury, nephritis and alcohol-induced toxicity in rat kidneys." | 3.74 | Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. ( Chen, CH; Chen, TH; Chu, YL; Hou, CC; Hsu, YH; Juan, SH; Lin, H; Sue, YM, 2007) |
| "Drug delivery systems containing gentamicin were studied as a treatment against experimental brucellosis in mice." | 3.74 | Poly(D,L-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice. ( Blanco-Prieto, MJ; Campanero, MA; Gamazo, C; Lecaroz, MC; Salman, H, 2007) |
| "To evaluate a new gentamicin-vancomycin- impregnated (2:1) PMMA coating nail as a drug delivery device to treat bone and intramedullary infections, methicillin-resistant Staphylococcus aureus (MRSA) was used to induce femoral osteomyelitis in 20 New Zealand male rabbits." | 3.74 | Preliminary investigations on a new gentamicin and vancomycin-coated PMMA nail for the treatment of bone and intramedullary infections: An experimental study in the rabbit. ( Borsari, V; Fini, M; Gaibani, P; Giardino, R; Giavaresi, G; Sambri, V; Soffiatti, R, 2008) |
| "The proven rat model for Staphylococcus aureus-induced osteomyelitis was used to compare the results of monotherapy with cefazolin, gentamicin-PMMA beads, or gentamicin-containing collagen sponge with the combination of local and systemic antibiotic treatment." | 3.73 | Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats. ( Heymann, H; Mendel, V; Scholz, HC; Simanowski, HJ, 2005) |
| "The therapeutic efficacy of an antimicrobial peptide, human lactoferrin 1-11 (hLF1-11), was investigated in a model of chronic methicillin-resistant Staphylococcus aureus (MRSA) (gentamicin susceptible) osteomyelitis in rabbits." | 3.73 | Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model. ( Faber, C; Joosten, U; Lyaruu, DM; Stallmann, HP; van Nieuw Amerongen, A; von Eiff, C; Wuisman, PI, 2005) |
| "We utilized a newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC) to investigate the effects of omeprazole and/or gentamicin on the formation of free oxygen radicals (FOR) and bowel histopathology." | 3.73 | Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats. ( Aritürk, E; Aydin, BK; Aydin, O; Bernay, F; Biçakçi, U; Eren, Z; Rizalar, R; Tander, B, 2005) |
| "To evaluate the efficacy of iontophoresis using a hydrogel probe containing gentamicin for the treatment of Pseudomonas keratitis in the rabbit cornea." | 3.73 | Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels. ( Domb, A; Eljarrat-Binstock, E; Frucht-Pery, J; Mechoulam, H; Raiskup, F; Shapiro, M, 2006) |
| "Gentamicin induced a consistent reduction in VOR responses and a progressive high-frequency hearing loss of 50-60 dB sound pressure level." | 3.72 | Protective effects of alpha-tocopherol against gentamicin-induced Oto-vestibulo toxicity: an experimental study. ( Ferraresi, A; Fetoni, AR; Paludetti, G; Scarano, E; Sergi, B; Troiani, D, 2003) |
| "A standard rat model of Staphylococcus aureus-induced osteomyelitis was used to compare the effect of HBO2, a local antibiotic carrier (gentamicin-containing collagen sponge) and the combination of HBO2 with a local antibiotic carrier." | 3.72 | Synergy of HBO2 and a local antibiotic carrier for experimental osteomyelitis due to Staphylococcus aureus in rats. ( Mendel, V; Scholz, HCh; Simanowski, HJ, 2004) |
| " Based on previous findings that tetracyclines revert abnormal physicochemical properties and abolish neurotoxicity of PrP peptides in vitro, we tested the ability of these compounds to interact with PrP(Sc) from patients with the new variant of Creutzfeldt-Jakob disease (vCJD) and cattle with bovine spongiform encephalopathy (BSE)." | 3.71 | Tetracyclines affect prion infectivity. ( Angeretti, N; Awan, T; Bertani, I; Bugiani, O; Caramelli, M; Colombo, L; Farina, L; Forloni, G; Giaccone, G; Girola, L; Grazia Bruzzone, M; Ironside, JW; Iussich, S; Limido, L; Poli, G; Rossi, G; Salmona, M; Tagliavini, F, 2002) |
| " Gentamicin (GE) acts mainly in proximal tubular cells, where it is uptake via organic anion transport system and it induces a high incidence of nephrotoxicity, which is characterized by tubular necrosis [5] leading to acute renal failure in 10 to 50% of patients." | 3.71 | Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells. ( Cunha, MA; Schor, N, 2002) |
| "Gentamicin was administered intraperitoneally, three times in 12 h to Hartley type guinea-pigs which had undergone complete unilateral ureteral obstruction with normal contralateral ureteral function for either 24 hours, 7 days or 21 days." | 3.71 | Gentamicin concentrations in urine, cortex and medulla in an acutely obstructed kidney animal model. ( Davila, NJ; Krhen, I; Mareković, Z; Skerk, V, 2001) |
| "To study the influence of gentamicin-containing sponges on the healing of colonic anastomoses in a rat model of peritonitis." | 3.70 | Effect of gentamicin-containing sponges on the healing of colonic anastomoses in a rat model of peritonitis. ( Eyskens, EJ; Hendriks, JM; Ieven, M; Lauwers, PR; Vaneerdeweg, W, 2000) |
| "The pharmacokinetics and efficacy of isepamicin were compared with those of amikacin and gentamicin in a rabbit model of endocarditis due to Klebsiella pneumoniae CF104 producing beta-lactamase TEM-3 and aminoglycoside acetyltransferase AAC(6')-IV." | 3.69 | Activity of isepamicin and selection of permeability mutants to beta-lactams during aminoglycoside therapy of experimental endocarditis due to Klebsiella pneumoniae CF104 producing an aminoglycoside acetyltransferase 6' modifying enzyme and a TEM-3 beta-l ( Carbon, C; Farinotti, R; Goldstein, F; Gutmann, L; Mainardi, JL; Mohler, J; Zhou, XY, 1994) |
| " rabbit model of Staphylococcus aureus osteomyelitis was used to compare 3 weeks of clindamycin-impregnated polymethylmethacralate (PMMA) bead treatment with 3 weeks of gentamicin-impregnated polymethylmethacralate bead treatment, 4 weeks of parenteral clindamycin treatment, and surgical debridement without any antibiotic treatment." | 3.69 | PMMA bead versus parenteral treatment of Staphylococcus aureus osteomyelitis. ( Heard, GS; Little, MD; Oloff, LM; Prins, DD; Wolfe, DA, 1997) |
| "N-[9H-(2,7-dimethylfluoren-9-ylmethoxy)carbonyl]-L-leucine (NPC 15669), a leukocyte recruitment inhibitor, was investigated for its ability to enhance survival in a rat model of sepsis, fecal peritonitis." | 3.68 | NPC 15669 reduces mortality associated with sepsis in rats. ( Burch, RM; Lowe, VC; Noronha-Blob, L; Otterbein, L; Steranka, L, 1993) |
| "Activity of aminoglycosides such as gentamicin, sisomicin and amikacin against plague microbe strains of natural origin was studied in vitro." | 3.68 | [Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague]. ( Bugaeva, OK; Kasatkina, IV; Makarovskaia, LN; Shcherbaniuk, AI, 1992) |
| "To clarify the role of corneal collagen shields as a drug delivery device for the treatment of bacterial keratitis, the authors studied the effectiveness of topical gentamicin treatment, with and without the use of corneal collagen shields, in a rabbit model of Pseudomonas keratitis." | 3.68 | Evaluation of corneal collagen shields as a drug delivery device for the treatment of experimental Pseudomonas keratitis. ( Silbiger, J; Stern, GA, 1992) |
| "Growing rats were exposed to noise and/or tinnitus-producing drugs (sodium salicylate, quinine, gentamycin)." | 3.68 | Tinnitus-induced weight loss in rats. An animal model for tinnitus research. ( Kellerhals, B; Zogg, R, 1991) |
| "An experimental Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats was used to study the impact of the duration of infection on the bactericidal activity of ceftazidime, gentamicin and ciprofloxacin." | 3.68 | Impact of the duration of infection on the activity of ceftazidime, gentamicin and ciprofloxacin in Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats. ( Bakker-Woudenberg, IA; Michel, MF; Roosendaal, R; van den Berghe-van Raffe, M; Vink-van den Berg, JC, 1991) |
| "The histologic and clinical effect of intravitreal dexamethasone was studied in a rabbit model of experimentally induced gentamicin sensitive Staphylococcal epidermidis endophthalmitis." | 3.68 | Effect of intravitreal dexamethasone on ocular histopathology in a rabbit model of endophthalmitis. ( Brent, BD; Diamond, JG; Maxwell, DP; Wu, L, 1991) |
| "In a rodent model of Escherichia coli brain abscess, the natural history of the infection was studied and the influence of a glucocorticoid (dexamethasone) and an antibiotic (gentamicin) on the development of brain abscess and the survival of abscess-bearing animals was evaluated." | 3.67 | Effect of gentamicin and dexamethasone on the natural history of the rat Escherichia coli brain abscess model with histopathological correlation. ( Blank, NK; Lawrence, MS; Neuwelt, EA, 1984) |
| "The pharmacokinetics and therapeutic efficacy of gentamicin were investigated in an experimental pleural empyema rabbit model." | 3.67 | Pharmacokinetics and therapeutic efficacy of gentamicin in an experimental pleural empyema rabbit model. ( Meyerovitch, J; Rubinstein, E; Shohet, I; Yellin, A, 1987) |
| " One group of animals (n = 9) received gentamicin 2 mg/kg intravenously infusion two hours after induction of sepsis with live E." | 3.67 | Increased plasma levels of endotoxin and corresponding changes in circulatory performance in a porcine sepsis model: the effect of antibiotic administration. ( Giercksky, KE; Osterud, B; Revhaug, A; Røkke, O, 1988) |
| "Trimethoprim-sulfadiazine and gentamicin sulfate decreased early mortality in an established model of fibrinous peritonitis in the rat." | 3.67 | Efficacies of trimethoprim-sulfadiazine and gentamicin sulfate in the treatment of fibrinous peritonitis in rats. ( Benson, CE; Emms, SG, 1987) |
| " The effects of ibuprofen, methylprednisolone-sodium succinate, and gentamicin alone, or in combination on survival time and, TxA2 and PGI2 production in rats in a LD100 fecal peritonitis shock model were assessed." | 3.67 | Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985) |
| "The therapeutic efficacy of ceftriaxone and gentamicin was investigated in a foreign body induced abscess model in the rat by implanting a dialysis tube contaminated with Klebsiella pneumoniae into the subcutaneous tissue." | 3.66 | Efficacy of ceftriaxone and gentamicin in an abscess model. ( Mark, Z; Pritsch, M; Rubinstein, E; Spicehandler, J, 1982) |
| "Moxalactam (LY127935) is a 1-oxa-beta-lactam which was active in vitro against the majority of 128 strains of gram-negative enteric bacilli isolated from meningitis in neonates." | 3.66 | Pharmacokinetics and bacteriological efficacy of moxalactam (LY127935), netilmicin, and ampicillin in experimental gram-negative enteric bacillary meningitis. ( Loock, CA; McCracken, GH; Schaad, UB; Thomas, ML, 1980) |
| "In a quantitative model of experimental Pseudomonas aeruginosa keratitis in guinea pigs, topical solutions of amikacin, gentamicin and tobramycin were equally effective." | 3.66 | Relative efficacy of the topical use of amikacin, gentamicin and tobramycin in experimental Pseudomonas keratitis. ( Davis, SD; Hyndiuk, RA; Sarff, LD, 1980) |
| "The pharmacokinetics and therapeutic efficacy of gentamicin and cefsulodin were studied in an abscess model in the rat induced by Pseudomonas aeruginosa and a foreign body." | 3.66 | Gentamicin and cefsulodin efficacy in a rat abscess model. ( Dreznik, Z; Mark, Z; Rubinstein, E, 1982) |
| "Antibiotic therapy of methicillin-resistant Staphylococcus epidermidis endocarditis was investigated with the rabbit endocarditis model." | 3.66 | Therapy of methicillin-resistant Staphylococcus epidermidis experimental endocarditis. ( Lowy, FD; Steigbigel, NH; Wexler, MA, 1982) |
| "The purpose of this study was to examine the pharmacokinetics of gentamicin renal uptake in dogs and assess the role of chronic renal ischemia." | 3.66 | Renal handling of gentamicin by normal and ischemic canine kidneys. ( Adelman, MH; Harrison, NJ; Schentag, JJ; Wels, PB, 1982) |
| " Staphylococcus aureus keratitis was treated either with neomycin sulfate or gentamicin sulfate, while Pseudomonas aeruginosa keratitis was treated either with gentamicin or polymyxin B sulfate." | 3.66 | Topically administered corticosteroids: effect on antibiotic-treated bacterial keratitis. ( Kupferman, A; Leibowitz, HM, 1980) |
| "The therapy of Proteus mirabilis meningitis with gentamicin alone and in combination with chloramphenicol was studied in a rabbit model." | 3.66 | Factors influencing the therapy of experimental Proteus mirabilis meningitis in rabbits. ( Sande, MA; Strausbaugh, LJ, 1978) |
| "Rats with obstructive pyelonephritis due to Escherichia coli were treated for different intervals with ampicillin and gentamicin either alone or in combination." | 3.66 | Synergism of ampicillin and gentamicin against obstructive pyelonephritis due to Escherichia coli in rats. ( Braude, AI; Glauser, MP; Lyons, JM, 1979) |
| "Using a rabbit sterile peritonitis model, we compared the penetration of intravenously administered amikacin, gentamicin, and penicillin G into peritoneal exudate." | 3.65 | Comparative penetration of amikacin, gentamicin, and penicillin g into exudate fluid in experimental sterile peritonitis. ( MacGregor, RR, 1977) |
| "Levels of rifampin, gentamicin, sisomicin, and cephalothin in normal and osteomyelitic rabbit bones were measured, and the efficacy of these drugs in the treatment of osteomyelitis was evaluated." | 3.65 | Experimental osteomyelitis. IV. Therapeutic trials with rifampin alone and in combination with gentamicin, sisomicin, and cephalothin. ( Norden, CW, 1975) |
| "Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicin-induced nephrotoxicity." | 2.79 | Calcium dobesilate for prevention of gentamicin-induced nephrotoxicity in rats. ( Changizi Ashtiyani, S; Jafarey, M; Najafi, H, 2014) |
| "Vancomycin is often combined with a second antibiotic, most often rifampin or gentamicin, for the treatment of serious methicillin-resistant Staphylococcus aureus infections." | 2.45 | Vancomycin in combination with other antibiotics for the treatment of serious methicillin-resistant Staphylococcus aureus infections. ( Deresinski, S, 2009) |
| "Gentamicin (GM) is a commonly prescribed antimicrobial drug used for treatment of infections but associated hepatic and renal complications restrict its efficacy." | 1.62 | The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats. ( Abdeen, A; Abdelkader, A; Abdullah, O; Aboubaker, M; Alsanie, WF; Baioumy, B; Elkomy, A; Elnoury, HA; Gaber, A; Habotta, OA; Ibrahim, SF; Samir, A, 2021) |
| "Gentamicin (GM) is an aminoglycoside antibiotic that despite its antibacterial effects, its use is restricted due to numerous side effects." | 1.62 | Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats. ( Baharvand, F; Hosseini, A; Mirazi, N; Moghadasali, R; Nourian, A, 2021) |
| "Acute kidney injury is a serious health hazard disease due to its complex etiology and lack of effective treatments, resulting in high medical costs and high mortality." | 1.62 | Method used to establish a large animal model of drug-induced acute kidney injury. ( Cai, GY; Chen, XM; Wang, SY; Zhang, CY, 2021) |
| "Gentamicin is an important broad-spectrum antibiotic; nevertheless, it exhibits serious nephrotoxic adverse effects." | 1.62 | HPLC-ESI/MS profiling, phytoconstituent isolation and evaluation of renal function, oxidative stress and inflammation in gentamicin-induced nephrotoxicity in rats of Ficus spragueana Mildbr. & Burret. ( Aboutabl, ME; Masoud, MA; Nassar, MI; Raslan, MA; Taher, RF, 2021) |
| "Acute kidney injury affects nearly 30% of preterm neonates in the intensive care unit." | 1.56 | Nephron loss detected by MRI following neonatal acute kidney injury in rabbits. ( Baldelomar, EJ; Bennett, KM; Cathro, HP; Charlton, JR; Charlton, NP; Criswell, SJ; deRonde, KA; Hyatt, DM; Nam, S; Pearl, V, 2020) |
| "Glioma is a CNS tumor with few therapeutic options." | 1.56 | Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice. ( Antonangeli, F; D'Alessandro, G; Lauro, C; Limatola, C; Marrocco, F; Porzia, A; Santoni, A, 2020) |
| "Gentamicin is an aminoglycoside antibiotic commonly administrated to patients with Gram-negative infections." | 1.56 | Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity. ( Janfeshan, S; Karimi, Z; Pakfetrat, Z; Roozbeh, J, 2020) |
| "Mice treated with gentamicin for 7 days developed AKI, and programmed cell death pathways were examined using pharmacologic inhibitors and in RIPK3-deficient mice." | 1.56 | Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct. ( Capen, DE; Huang, H; Huang, M; Ji, H; Jin, WW; Lu, HAJ; Păunescu, TG; Xia, Y; Yuan, J, 2020) |
| "Chronic osteomyelitis is difficult to treat, with biofilm growth and the diffusion barrier to antibiotics presented by bone contributory factors." | 1.51 | An in vitro biofilm model of Staphylococcus aureus infection of bone. ( Bowker, KE; Lovering, AM; MacGowan, AP; Nelson, SM; Sweeney, E, 2019) |
| "Gentamicin (GM) is an aminoglycoside antibiotic used to treat several types of bacterial infections." | 1.48 | Anticonvulsant effect of gentamicin on the seizures induced by kainic acid. ( Ji, Y; Jiang, N; Kuang, P; Lao, W; Lin, W; Wang, Z; Yin, T; Zhao, Y; Zhu, H, 2018) |
| "A challenge in the treatment of Staphylococcus aureus infections is the high prevalence of methicillin-resistant S." | 1.48 | A new class of synthetic retinoid antibiotics effective against bacterial persisters. ( Ausubel, FM; Conery, AL; Fricke, N; Fuchs, BB; Gao, H; Gilmore, MS; Hendricks, GL; Keohane, CE; Kim, W; Lee, K; Mylonakis, E; Pan, W; Rajamuthiah, R; Shen, S; Steele, AD; Van Tyne, D; Vlahovska, PM; Wuest, WM; Zhu, W, 2018) |
| "Current drug candidates used to treat hearing loss commonly have low efficacy." | 1.48 | Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss. ( Gao, H; Hou, S; Kuang, X; Liu, H; Wang, Z; Yang, Y; Zhou, S, 2018) |
| "After inducing nonlethal septic arthritis in the knee joint by injecting 10 colony-forming units (CFUs) of a strain of methicillin-sensitive S aureus in groups A, B, C, and D, rabbits were housed for 15 days, and then the joint capsules were removed and the remaining bacteria were counted." | 1.48 | Intra-articular Gentamicin-loaded PLA Microparticle Injection for the Treatment of Septic Arthritis in Rabbits. ( Fiorenza, F; Leclercq, X; Marcheix, PS; Martin, C; Sturtz, F, 2018) |
| "Gentamicin is an aminoglycoside antibiotic widely used for the treatment of life-threatening infections caused by Gram-negative bacteria." | 1.48 | Protective effect of Rotula aquatica Lour against gentamicin induced oxidative stress and nephrotoxicity in Wistar rats. ( A, V; Jyothis, M; Kuriakose, J; Latha, MS; Midhun, SJ; S, A, 2018) |
| "Gentamicin treatment decreased fall latency of mice and gentamicin treatment together with alpha-linolenic acid increased fall latency of mice." | 1.46 | Protective effect of alpha-linolenic acid on gentamicin-induced ototoxicity in mice. ( Doran, F; Erdoğan, KE; Kaplan, HM; Şingirik, E, 2017) |
| "Gentamicin is an aminoglycoside antibiotic widely used in the treatment of infections caused by Gram-negative bacteria." | 1.46 | Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression. ( Buemi, A; Buemi, M; Cernaro, V; Costantino, G; Lacquaniti, A; Macrì, F; Maricchiolo, G; Ricciardi, CA; Rifici, C; Santoro, D; Sfacteria, A, 2017) |
| "Dipyridamole pretreatment in gentamicin-administered rats afforded a noticeable renoprotection by markedly preventing renal structural and functional abnormalities, renal inflammation and serum uric acid elevation." | 1.46 | Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat. ( Bahari, MB; Balakumar, P; Gan, YS; Jayachristy, SA; JemayPuah, SM; Kuganesswari, S; Prajapati, SK; Sundram, K; Varatharajan, R; WitnessKoe, WE, 2017) |
| "Gentamicin was injected into the left cochleae of guinea pigs to induce apoptosis of SGCs; the contralateral cochleae served as controls." | 1.43 | Effects of Memantine on Aminoglycoside-Induced Apoptosis of Spiral Ganglion Cells in Guinea Pigs. ( Bae, WY; Hur, DY; Kim, BY; Kim, JR; Koh, TK; Lee, TH; Park, GB, 2016) |
| " We tested the effectiveness of gentamicin in combination with ESW treatment against S." | 1.43 | Increased Effects of Extracorporeal Shock Waves Combined with Gentamicin against Staphylococcus aureus Biofilms In Vitro and In Vivo. ( Chen, C; Chen, X; Han, D; Huang, Y; Li, X; Qi, X; Wang, T; Zhang, J; Zhang, X; Zhao, Y, 2016) |
| "Fosfomycin is an alternative antimicrobial agent that lacks the cross-resistance presented by other classes of antibiotics." | 1.43 | Fosfomycin Addition to Poly(D,L-Lactide) Coating Does Not Affect Prophylaxis Efficacy in Rat Implant-Related Infection Model, But That of Gentamicin Does. ( Akman, A; Bir, F; Demirkan, AF; Gulcu, A; Kaleli, I; Yorukoglu, AC, 2016) |
| "(1) Gentamicin release was sustained over 7 days with the higher-dose formulation release profile similar to release from high-dose antimicrobial-loaded bone cement." | 1.42 | Local gentamicin delivery from resorbable viscous hydrogels is therapeutically effective. ( Calara, F; McLaren, A; McLemore, R; Overstreet, D; Vernon, B, 2015) |
| "Many have neonatal phenotypes." | 1.42 | ECG in neonate mice with spinal muscular atrophy allows assessment of drug efficacy. ( DiDonato, CJ; Heier, CR, 2015) |
| "pestis CO92 to evoke pneumonic plague in a mouse model while retaining the required immunogenicity needed for subsequent protection against infection." | 1.42 | Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague. ( Andersson, JA; Baze, WB; Chauhan, S; Chopra, AK; Erova, TE; Kirtley, ML; Motin, VL; Ponnusamy, D; Popov, VL; Sha, J; Tiner, BL; van Lier, CJ, 2015) |
| " Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage." | 1.42 | Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase. ( Blanco-Gozalo, V; García-Sánchez, O; González-Buitrago, JM; López-Hernández, FJ; López-Novoa, JM; Morales, AI; Pescador, M; Sánchez-Juanes, F; Sevilla, MA; Vicente-Vicente, L, 2015) |
| "Gentamicin is a commonly used aminoglycoside antibiotic, whose ototoxicity remains a major problem in clinical use." | 1.42 | The effect of radiotherapy on gentamicin ototoxicity: an animal model. ( Bezdjian, A; Daniel, SJ; Devic, S; Mujica-Mota, MA, 2015) |
| "Atorvastatin has antioxidant activity and has been reported to increase blood antioxidant capacity." | 1.42 | Paradoxical effects of atorvastatin on renal tubular cells: an experimental investigation. ( Ahmadi, A; Baradaran, A; Hasanpour, Z; Nasri, H; Nasri, P; Nematbakhsh, M; Rafieian-Kopaei, M, 2015) |
| "Chronic kidney disease, end-stage renal failure, and liver diseases are increasing worldwide and constitute a huge burden on health care costs, with attendant high morbidity and debility." | 1.40 | Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats. ( Akah, PA; Ihim, SA; Laiyemo, KA; Nworu, CS; Ugwu, LE, 2014) |
| "Gentamicin was used as a damage factor in the culture of renal tubular epithelial cells (RTECs) in vitro." | 1.39 | Study on therapeutic action of bone marrow derived mesenchymal stem cell combined with vitamin E against acute kidney injury in rats. ( Dong, C; Feng, Y; Liu, D; Liu, P; Lv, P; Wu, H; Wu, X; Zhou, Y, 2013) |
| "Nephrotoxicity is a serious side effect of gentamicin and is believed to be related to reactive oxygen species in the kidney." | 1.39 | Ethanolic extract of garlic for attenuation of gentamicin-induced nephrotoxicity in Wistar rats. ( Nasri, H; Nematbakhsh, M; Rafieian-Kopaei, M, 2013) |
| "Docusate sodium was severely ototoxic, and its use should be discouraged." | 1.38 | Ototoxicity of intratympanic docusate sodium and mineral oil in the guinea pig. ( Nader, ME; Saliba, I, 2012) |
| " However, the optimal aminoglycoside or the optimal dosage remains uncertain." | 1.38 | The optimal aminoglycoside and its dosage for the treatment of severe Enterococcus faecalis infection. An experimental study in the rabbit endocarditis model. ( Asseray, N; Bugnon, D; Caillon, J; Dubé, L; Jacqueline, C; Potel, G, 2012) |
| " In the LPSIL+GE group relative to C+GE, the half-life (t(1/2)) was 79% higher (p<0." | 1.38 | A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2. ( Chládek, J; Krs, O; Martinkova, J; Senkerik, M; Slizova, D; Springer, D; Studena, S, 2012) |
| " Toxicity is dose related, but some patients may still develop hearing loss even under safe dosage." | 1.37 | Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway. ( Hsu, CJ; Kao, MC; Lai, CH; Lin, CD; Lin, CW; Lin, CY; Tang, CH; Tsai, MH; Wei, IH, 2011) |
| "Hearing and balance receptors in the inner ear are highly susceptible to damage caused by a wide variety of toxic substances, including aminoglycosides." | 1.36 | Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. ( Cediel, R; Contreras, J; Murillo-Cuesta, S; Varela-Nieto, I, 2010) |
| "The gentamicin-treated group showed a marked increase in SCr compared to the normal control group." | 1.36 | The modifier protein of glyceraldehyde-3-phosphate dehydrogenase reduces free radical-mediated renal damage in a rat model of acute kidney injury. ( Fan, QL; Li, ZL; Liang, ZF; Ma, JF; Ren, Q; Sun, YH; Wang, J; Wang, LN, 2010) |
| "Gentamicin (100mg/mL) was the agent of choice as it is an extensively-studied human ototoxin." | 1.36 | Physiological dimensions of ototoxic responses in a model fish species. ( Brack, CL; Ramcharitar, JU, 2010) |
| "Gentamicin (GM) is an effective antibiotic against severe infection but has limitations related to nephrotoxicity." | 1.36 | Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure. ( Bissada, NK; Eladl, M; Hellstrom, WJ; Kamel, M; Maarouf, AM; Salem, EA; Salem, NA, 2010) |
| "Tetramethylpyrazine (TMP) is a compound purified from the rhizome of Ligusticum wallichi (called chuanxiong in Chinese)." | 1.35 | Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells. ( Chang, CC; Chen, CH; Cheng, CF; Chou, Y; Juan, SH; Sue, YM, 2009) |
| " The dogma of gentamicin ototoxicity theorizes that (1) the toxic effects of the drug are cumulative and dose dependent, despite clinical observations of ototoxicity after a single dose, and (2) gentamicin's ototoxic effects are irreversible, although clinicians have observed improvement in hearing over time." | 1.35 | Ototoxic effects of single-dose versus 19-day daily-dose gentamicin. ( Blakley, BW; Blakley, L; Gooi, A; Hochman, J; Wellman, M, 2008) |
| "Gentamicin is an aminoglycoside antibiotic that induces severe nephrotoxicity and acute renal failure." | 1.35 | Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury. ( Bledsoe, G; Chao, J; Chao, L; Grass, D; Hagiwara, M; Mizell, B; Shen, B; Teuton, M; Yao, YY, 2008) |
| "9% NaCl, group A2 received the same dosage of gentamicin and ampicillin in two different 36 mL 0." | 1.35 | Moxifloxacin versus ampicillin + gentamicin in the therapy of experimental Listeria monocytogenes meningitis. ( Arda, B; Calik, S; Pullukcu, H; Sipahi, H; Sipahi, OR; Tasbakan, M; Turhan, T; Ulusoy, S; Yamazhan, T, 2008) |
| "and gentamicin group was injected with gentamicin in the dose of 80 mg/kg/day i." | 1.33 | Nitric oxide in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović, A; Mijanović, M; Nakas-Ićindić, E; Prasović, S; Tahirović, G; Zaciragić, A, 2005) |
| " The aim of this study was to compare the therapeutic efficacy of quinupristin-dalfopristin (QD) alone, or in combination with gentamicin (G), teicoplanin (T), imipenem (I) or levofloxacin (L) against a strain of multidrug-resistant E." | 1.33 | [Comparative study of treatment with quinupristin-dalfopristin alone or in combination with gentamicin, teicoplanin, imipenem or levofloxacin in experimental endocarditis due to a multidrug-resistant Enterococcus faecium]. ( Gómez Gómez, J; López Fornás, F; Lorente Salinas, I; Martínez García, F; Pérez Salmerón, J; Roldán Conesa, D; Ruiz Gómez, J; Segovia Hernández, M; Valdés Chávarri, M, 2006) |
| " This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model." | 1.32 | Simulation of human gentamicin pharmacokinetics in an experimental Enterococcus faecalis endocarditis model. ( Bugnon, D; Caillon, J; Dubé, L; Granry, JC; Gras-Le Guen, C; Jacqueline, C; Kergueris, MF; Potel, G, 2003) |
| " The purpose of this study was to evaluate the in vivo activity of linezolid combined with gentamicin using a methicillin-resistant Staphylococcus aureus (MRSA) endocarditis experimental model." | 1.32 | In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. ( Asseray, N; Batard, E; Bugnon, D; Caillon, J; Dube, L; Jacqueline, C; Kergueris, MF; Le Mabecque, V; Potel, G, 2004) |
| "We investigated the activity of LY333328 alone and combined with gentamicin, both in vitro and in a rabbit model of experimental endocarditis, against the susceptible strain Enterococcus faecalis JH2-2 and its two glycopeptide-resistant transconjugants, BM4316 (VanA) and BM4275 (VanB)." | 1.31 | Activity of LY333328 combined with gentamicin in vitro and in rabbit experimental endocarditis due to vancomycin-susceptible or -resistant Enterococcus faecalis. ( Carbon, C; Fantin, B; Garry, L; Lefort, A; Saleh-Mghir, A, 2000) |
| " Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Differential toxicity synchronized with renal dysfunction process could be identified using 5/6 NX rats" was examined by dosing gentamicin." | 1.31 | Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach. ( Barata, K; Harada, E; Hokao, R; Imai, S; Maekawa, A; Takahashi, S; Yoshida, M, 2001) |
| " In contrast, a higher dosing regimen of vancomycin (i." | 1.31 | Consequences of VanE-type resistance on efficacy of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecalis. ( Carbon, C; Courvalin, P; Fantin, B; Lafaurie, M; Lefort, A; Perichon, B, 2001) |
| " The dose-response curves for each test did not deviate significantly from parallelism." | 1.31 | Antinociceptive potency of aminoglycoside antibiotics and magnesium chloride: a comparative study on models of phasic and incisional pain in rats. ( Machado Filho, EB; Prado, WA, 2002) |
| "More netilmicin was eluted from fine morselized bone than from coarse morselized bone." | 1.31 | Release of netilmicin and vancomycin from cancellous bone. ( Benum, P; Bergh, K; Persen, L; Witsø, E, 2002) |
| "Gentamicin (5 mg/kg) was administered over 1 minute, and serum levels were obtained at 15-minute intervals." | 1.30 | Pulmonary administration of gentamicin during liquid ventilation in a newborn lamb lung injury model. ( Cox, C; Drott, H; Farina, C; Fox, WW; Shaffer, TH; Weis, CM; Wolfson, MR, 1997) |
| "Gentamicin level was also measured inside the ceramic implant." | 1.30 | [Tricalcium phosphate, an antibiotic carrier: a study focused on experimental osteomyelitis in rabbits]. ( Cathelineau, G; Lambotte, JC; Lancien, G; Langlais, F; Minet, J; Thomazeau, H, 1998) |
| "HAC is an effective adjuvant in treating chronic osteomyelitis in a rat model when using a void-fill placement technique." | 1.30 | Efficacy of gentamycin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model. ( Baumgaertner, MR; Gutow, AP; Solberg, BD, 1999) |
| "Ten chinchillas underwent left middle ear instillation of one of three agents using variable dosing schedules: gentamicin (n = 6), streptomycin (n = 2), and saline (n = 2) as control." | 1.30 | Middle ear instillation of gentamicin and streptomycin in chinchillas: morphologic appraisal of selective ototoxicity. ( Chen, JM; Harrison, RV; Hirakawa, H; Kakigi, A; Mount, RJ, 1999) |
| " faecalis clinical isolate, the animals received IFN-gamma, antibiotic or a combination of both agents, subcutaneously, at determined dosing regimens." | 1.30 | Influence of adjunctive interferon-gamma on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice. ( Bow, L; Bui, KQ; Nicolau, DP; Nightingale, CH; Onyeji, CO; Quintiliani, R, 1999) |
| "Osteomyelitis is generally treated by the systemic administration of antibiotics and continuous irrigation after curettage of the lesion, and bone graft is performed secondarily to treat any bone defect." | 1.30 | Apatite cement containing antibiotics: efficacy in treating experimental osteomyelitis. ( Ishii, Y; Sasaki, S, 1999) |
| "A pharmacokinetic study of gentamicin (5 mg/kg intravenous (i." | 1.29 | Pharmacokinetics of gentamicin following single dose intravenous administration in normal and febrile goats. ( Ahmad, AH; Bahga, HS; Sharma, LD, 1994) |
| "Gentamicin sulfate was given as a single injection (100 mg/kg of body weight subcutaneously), followed 90 minutes later by varying concentrations of ethacrynic acid intravenously." | 1.29 | A sensitive animal model to assess acute and chronic ototoxic effects. ( Lautermann, J; Schacht, J, 1996) |
| "No meningitis was observed in rats receiving 25 mg of cefotaxime/kg." | 1.29 | Model of Streptococcus pneumoniae meningitis in adult rats. ( Alder, JD; Ewing, PJ; Mitten, MJ; Strake, JG, 1996) |
| "Gentamicin-treated mice received a single 15 mg/kg injection of gentamicin at the time of CLP." | 1.28 | Treatment of intra-abdominal infection with granulocyte colony-stimulating factor. ( Davis, JH; Gamelli, RL; Greenhalgh, DG; Hebert, JC; O'Reilly, M; Silver, GM, 1992) |
| " These results support the idea that the major significance of the PAE is in its application to dosing regimens." | 1.28 | In vivo postantibiotic effect of isepamicin and other aminoglycosides in a thigh infection model in neutropenic mice. ( Caminero, MM; Fuentes Martinez, F; Izquierdo Izquierdo, J; Minguez Minguez, F; Prieto Prieto, J, 1992) |
| "Pseudomonas otitis externa is one of the most common infections treated by otolaryngologists." | 1.28 | Gentamicin iontophoresis in the treatment of bacterial otitis externa in the guinea pig model. ( Estrem, SA; King, DM, 1990) |
| " A dose-response experiment was performed with a daily dose of 0." | 1.28 | Liposome-encapsulated-gentamicin therapy of Mycobacterium avium complex infection in beige mice. ( Cynamon, MH; Ginsberg, RS; Klemens, SP; Swenson, CE, 1990) |
| " We compared the relative efficacy and potency of three beta-lactams and two aminoglycosides in lung and thigh-infection models in neutropenic mice by defining the maximum attainable antimicrobial effect at 24 h (Emax) and the total dose required to reach 50% of maximum effect (P50) at several dosing intervals." | 1.28 | Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection models. ( Calame, W; Craig, WA; Ebert, S; Fantin, B; Leggett, JE; Mattie, H; Totsuka, K; Vogelman, B, 1989) |
| "The efficacy of various dosage schedules of netilmicin against Pseudomonas aeruginosa has been compared using an in vivo model (normal and granulocytopenic mice)." | 1.27 | [Bolus injection, short infusion or intravenous drip of aminoglycoside antibiotics? In vivo study with netilmicin and Pseudomonas aeruginosa]. ( Brugger, HP; Feller-Segessenmann, C; Gerber, AU, 1983) |
| " Preclinical trials in an animal model could permit earlier detection of promising agents and proper dosage schedules." | 1.27 | Experimental osteomyelitis: description of a canine model and the role of depot administration of antibiotics in the prevention and treatment of sepsis. ( Fitzgerald, RH, 1983) |
| "Carbenicillin was used alone and in combination with sisomicin in the treatment of experimental pseudomonas osteomyelitis." | 1.26 | Experimental osteomyelitis caused by Pseudomonas aeruginosa. ( Keleti, E; Norden, CW, 1980) |
| " There was a marked variation in incidence of abscess dependent upon the cephalosporin selected and the dosage tested." | 1.26 | Therapy for experimental intraabdominal sepsis: comparison of four cephalosporins with clindamycin plus gentamicin. ( Bartlett, JG; Gorbach, SL; Louie, TJ; Onderdonk, AB, 1977) |
| "Pyelonephritis was produced in 75 white rats by applying a 24-hour ligature on the ureter and by intravenous injection of a suspension of 5X10(9) cells of a stable Proteus mirabilis L-form." | 1.26 | Experimental pyelonephritis induced by L-forms of Proteus mirabilis in rats. ( Gregoriev, D; Gumpert, J; Harizanova, T; Kujumgiev, A; Toshkov, A; Tsenova, Z; Zacharieva, S, 1978) |
| "Peak serum levels of gentamicin were varied in rats by administering a standard nephrotoxic dosage of 40 mg/kg per day in one (QD), two, or three (TID) daily doses." | 1.26 | The influence of dosage regimen on experimental gentamicin nephrotoxicity: dissociation of peak serum levels from renal failure. ( Bennett, WM; Gilbert, DN; Parker, RA; Plamp, CE; Porter, GA, 1979) |
| " An identical dosage of tobramycin was associated with only minimal morphological changes and normal concentrations of serum creatinine and blood urea nitrogen." | 1.26 | Comparative nephrotoxicity of gentamicin and tobramycin in rats. ( Bennet, WM; Gilbert, DN; Houghton, DC; Plamp, C; Porter, G; Starr, P, 1978) |
| "In vivo tests on experimental Proteus infections of rabbit coreas, treated with gentamicin and tobramycin, yielded comparable clinical results, but gentamicin was more effective in eliminating the organism from the experimental lesions." | 1.26 | Proteus species isolated from human eyes. ( Belfort, R; Kim, HB; Okumoto, M; Siverio, CE; Smolin, G, 1976) |
| "Gentamicin sulfate was given to rabbits for four weeks in two dosage regimens, either 4 or 8 mg/kg subcutaneously twice a day." | 1.26 | Renal glycosuria due to gentamicin in rabbits. ( Ginsburg, DS; Levin, M; Quintanilla, AP, 1976) |
| " Moreover, their combination made it possible to reduce the dosage of the antibiotics and thereby reduce their potential undesirable effect." | 1.25 | An experimental model of Pseudomonas aeruginosa renal infection in rats. ( Hatala, M; Konícková, L; Liska, M; Prát, V; Slugen, I, 1975) |
| "Treatment with gentamicin reduced the acute mortality rate to 4%, but 98% of the survivors had abscesses." | 1.25 | Antimicrobial therapy of experimental intraabdominal sepsis. ( Bartlett, JG; Gorbach, SL; Louie, TJ; Onderdonk, AB; Weinstein, WM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 104 (21.85) | 18.7374 |
| 1990's | 80 (16.81) | 18.2507 |
| 2000's | 101 (21.22) | 29.6817 |
| 2010's | 162 (34.03) | 24.3611 |
| 2020's | 29 (6.09) | 2.80 |
| Authors | Studies |
|---|---|
| Laaroussi, H | 1 |
| Bakour, M | 1 |
| Ousaaid, D | 1 |
| Ferreira-Santos, P | 1 |
| Genisheva, Z | 1 |
| El Ghouizi, A | 1 |
| Aboulghazi, A | 1 |
| Teixeira, JA | 1 |
| Lyoussi, B | 1 |
| Stærk, K | 1 |
| Grønnemose, RB | 1 |
| Nielsen, TK | 1 |
| Petersen, NA | 1 |
| Palarasah, Y | 1 |
| Torres-Puig, S | 1 |
| Møller-Jensen, J | 1 |
| Kolmos, HJ | 1 |
| Lund, L | 1 |
| Andersen, TE | 1 |
| Abdeen, A | 1 |
| Samir, A | 1 |
| Elkomy, A | 1 |
| Aboubaker, M | 1 |
| Habotta, OA | 1 |
| Gaber, A | 1 |
| Alsanie, WF | 1 |
| Abdullah, O | 1 |
| Elnoury, HA | 1 |
| Baioumy, B | 1 |
| Ibrahim, SF | 1 |
| Abdelkader, A | 1 |
| Isguven, S | 1 |
| Fitzgerald, K | 1 |
| Delaney, LJ | 1 |
| Harwood, M | 1 |
| Schaer, TP | 1 |
| Hickok, NJ | 1 |
| Rahimi, S | 1 |
| Bakht, M | 1 |
| Javadi, A | 1 |
| Foroughi, F | 1 |
| Marashi, SMA | 1 |
| Nikkhahi, F | 1 |
| Ren, H | 1 |
| Liu, Y | 3 |
| Zhou, J | 1 |
| Long, Y | 1 |
| Liu, C | 3 |
| Xia, B | 1 |
| Shi, J | 1 |
| Fan, Z | 2 |
| Liang, Y | 2 |
| Chen, S | 1 |
| Xu, J | 2 |
| Wang, P | 1 |
| Zhang, Y | 7 |
| Zhu, G | 1 |
| Liu, H | 2 |
| Jin, Y | 1 |
| Bai, F | 1 |
| Cheng, Z | 1 |
| Jin, S | 1 |
| Wu, W | 1 |
| Helmy, MM | 1 |
| Mouneir, SM | 1 |
| Roukoz, S | 1 |
| El Khoury, G | 1 |
| Saghbini, E | 1 |
| Saliba, I | 2 |
| Khazzaka, A | 1 |
| Rizkallah, M | 1 |
| Charlton, JR | 2 |
| Baldelomar, EJ | 2 |
| deRonde, KA | 1 |
| Cathro, HP | 1 |
| Charlton, NP | 1 |
| Criswell, SJ | 1 |
| Hyatt, DM | 1 |
| Nam, S | 1 |
| Pearl, V | 1 |
| Bennett, KM | 2 |
| D'Alessandro, G | 1 |
| Antonangeli, F | 1 |
| Marrocco, F | 1 |
| Porzia, A | 1 |
| Lauro, C | 1 |
| Santoni, A | 1 |
| Limatola, C | 1 |
| Han, C | 2 |
| Sun, T | 1 |
| Fan, G | 1 |
| Zhang, W | 3 |
| Sohail, MR | 1 |
| Esquer Garrigos, Z | 1 |
| Elayi, CS | 1 |
| Xiang, K | 1 |
| Catanzaro, JN | 1 |
| Sancho-Martínez, SM | 2 |
| Blanco-Gozalo, V | 2 |
| Quiros, Y | 2 |
| Prieto-García, L | 1 |
| Montero-Gómez, MJ | 1 |
| Docherty, NG | 1 |
| Martínez-Salgado, C | 2 |
| Morales, AI | 3 |
| López-Novoa, JM | 4 |
| López-Hernández, FJ | 4 |
| Karimi, Z | 1 |
| Pakfetrat, Z | 1 |
| Roozbeh, J | 1 |
| Janfeshan, S | 1 |
| Parvin, N | 1 |
| Derakhshan, JJ | 1 |
| Merritt, JK | 2 |
| Collins, BE | 1 |
| Erickson, KR | 1 |
| Dong, H | 1 |
| Neul, JL | 2 |
| Alam, W | 1 |
| Khan, H | 1 |
| Khan, SA | 1 |
| Ali, N | 1 |
| Sharif, N | 1 |
| Ghafar, R | 1 |
| Daglia, M | 1 |
| Nazir, S | 1 |
| Huang, H | 1 |
| Jin, WW | 1 |
| Huang, M | 1 |
| Ji, H | 1 |
| Capen, DE | 1 |
| Xia, Y | 1 |
| Yuan, J | 1 |
| Păunescu, TG | 1 |
| Lu, HAJ | 1 |
| Mirazi, N | 1 |
| Baharvand, F | 1 |
| Moghadasali, R | 1 |
| Nourian, A | 1 |
| Hosseini, A | 1 |
| Wang, L | 1 |
| Tkhilaishvili, T | 1 |
| Bernal Andres, B | 1 |
| Trampuz, A | 2 |
| Gonzalez Moreno, M | 1 |
| Jeon, BS | 1 |
| Lee, SH | 1 |
| Hwang, SR | 1 |
| Yi, H | 1 |
| Bang, JH | 1 |
| Tham, NTT | 1 |
| Lee, HK | 1 |
| Woo, GH | 1 |
| Kang, HG | 1 |
| Ku, HO | 1 |
| Sun, B | 1 |
| Qu, Z | 1 |
| Cheng, GL | 1 |
| Yang, YW | 1 |
| Miao, YF | 1 |
| Chen, XG | 1 |
| Zhou, XB | 1 |
| Li, B | 3 |
| McHugh, DR | 1 |
| Cotton, CU | 1 |
| Hodges, CA | 1 |
| Wang, SY | 1 |
| Zhang, CY | 1 |
| Cai, GY | 1 |
| Chen, XM | 1 |
| Eltawila, AM | 1 |
| Hassan, MN | 1 |
| Safaan, SM | 1 |
| Abd El-Fattah, A | 1 |
| Zakaria, O | 1 |
| El-Khordagui, LK | 1 |
| Kandil, S | 1 |
| Taher, RF | 1 |
| Raslan, MA | 1 |
| Masoud, MA | 1 |
| Nassar, MI | 1 |
| Aboutabl, ME | 1 |
| Koun, S | 1 |
| Eom, Y | 1 |
| Kim, MJ | 1 |
| Kim, S | 1 |
| Lee, IH | 1 |
| Park, HC | 1 |
| Song, JS | 1 |
| Kim, HM | 1 |
| Chai, Y | 1 |
| He, W | 1 |
| Yang, W | 1 |
| Hetrick, AP | 1 |
| Gonzalez, JG | 1 |
| Sargsyan, L | 1 |
| Wu, H | 2 |
| Jung, TTK | 1 |
| Li, H | 2 |
| Beenken, KE | 1 |
| Campbell, MJ | 1 |
| Ramirez, AM | 1 |
| Alghazali, K | 1 |
| Walker, CM | 1 |
| Jackson, B | 1 |
| Griffin, C | 1 |
| King, W | 1 |
| Bourdo, SE | 1 |
| Rifkin, R | 1 |
| Hecht, S | 1 |
| Meeker, DG | 1 |
| Anderson, DE | 1 |
| Biris, AS | 1 |
| Smeltzer, MS | 1 |
| Ruiz-Ramirez, C | 1 |
| Antaño-Martinez, AR | 1 |
| Robles, J | 1 |
| Gallegos-Corona, MA | 1 |
| Gallegos-Reyes, MA | 1 |
| Avila, EE | 1 |
| Martinez-Alfaro, M | 1 |
| Bencheikh, N | 1 |
| Bouhrim, M | 1 |
| Kharchoufa, L | 1 |
| Al Kamaly, OM | 1 |
| Mechchate, H | 1 |
| Es-Safi, I | 1 |
| Dahmani, A | 1 |
| Ouahhoud, S | 1 |
| El Assri, S | 1 |
| Eto, B | 1 |
| Bnouham, M | 1 |
| Choukri, M | 1 |
| Elachouri, M | 1 |
| Casanova, AG | 1 |
| Vicente-Vicente, L | 2 |
| Hernández-Sánchez, MT | 1 |
| Pescador, M | 2 |
| Prieto, M | 1 |
| Edizer, DT | 1 |
| Yigit, O | 1 |
| Cinar, Z | 1 |
| Gul, M | 1 |
| Kara, E | 1 |
| Yigitcan, B | 1 |
| Hayır, D | 1 |
| Atas, A | 1 |
| Hegazy, AM | 1 |
| Abdel-Azeem, AS | 1 |
| Zeidan, HM | 1 |
| Ibrahim, KS | 1 |
| Sayed, EE | 1 |
| Olekson, MA | 1 |
| Rose, LF | 1 |
| Carlsson, AH | 1 |
| Fletcher, JL | 1 |
| Leung, KP | 1 |
| Chan, RK | 1 |
| Richter, K | 1 |
| Thomas, N | 1 |
| Zhang, G | 1 |
| Prestidge, CA | 1 |
| Coenye, T | 1 |
| Wormald, PJ | 1 |
| Vreugde, S | 1 |
| Trojan, BP | 1 |
| Trojan, SJ | 1 |
| Navetta, A | 1 |
| Staches, B | 1 |
| Sutton, B | 1 |
| Filleur, S | 1 |
| Nelius, T | 1 |
| Kaplan, HM | 1 |
| Şingirik, E | 1 |
| Erdoğan, KE | 1 |
| Doran, F | 1 |
| Hu, JG | 1 |
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| Xu, JJ | 1 |
| Ding, XP | 1 |
| Xie, HQ | 1 |
| Li-Ling, J | 2 |
| Zhao, Y | 3 |
| Wang, Z | 3 |
| Lao, W | 1 |
| Kuang, P | 1 |
| Jiang, N | 1 |
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| Lykke, M | 1 |
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| Smith, GP | 1 |
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| Dean, MA | 1 |
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| Long, SW | 1 |
| Rosato, AE | 1 |
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| Liu, K | 2 |
| Shi, C | 1 |
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| Shi, L | 2 |
| Wang, X | 4 |
| Ji, F | 2 |
| Hou, Z | 2 |
| Li, SA | 1 |
| Liu, J | 2 |
| Xiang, Y | 1 |
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| Liapunov, NA | 1 |
| Starobinets, ZG | 1 |
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| Bermudez, LE | 1 |
| Yau-Young, AO | 1 |
| Lin, JP | 1 |
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| Young, LS | 2 |
| Chavanet, P | 1 |
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| Portier, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Control Trial of Vancomycin Powder Following Posterior Instrumented Spinal Surgery for Trauma[NCT01977989] | Phase 4 | 140 participants (Anticipated) | Interventional | 2013-10-31 | Enrolling by invitation | ||
| Comparative Effectiveness and Cost-Benefit Analysis of Vancomycin Powder in High Risk Spine Surgery Patients[NCT01566422] | 0 participants (Actual) | Interventional | 2012-06-30 | Withdrawn (stopped due to unable to enroll any participants) | |||
| First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation[NCT02725463] | 30 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | |||
| Vestibular Implantation in Older Adults[NCT05676944] | 15 participants (Anticipated) | Interventional | 2023-04-11 | Recruiting | |||
| Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction[NCT05674786] | 8 participants (Anticipated) | Interventional | 2023-02-28 | Recruiting | |||
| Phase I Study Evaluating the Safety of Bevacizumab in Women With a History of Breast Cancer Suffering From Moderate to Severe Upper Extremity Lymphedema[NCT00318513] | Phase 1 | 35 participants | Interventional | Not yet recruiting | |||
| Use of Collatamp G Antibiotic Impregnated Sponges in the Treatment of Peri-prosthetic Total Joint Infections[NCT01667874] | Phase 3 | 17 participants (Actual) | Interventional | 2013-01-31 | Terminated (stopped due to Difficulty in recruiting patients for the study) | ||
| A Phase 1, Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of a Single 3 Gram Dose of Cefazolin in Adult Subjects Weighing >= 120 kg Scheduled for Surgery[NCT05205486] | Phase 1 | 12 participants (Actual) | Interventional | 2022-04-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for gentamicin and Disease Models, Animal
| Article | Year |
|---|---|
Vancomycin in combination with other antibiotics for the treatment of serious methicillin-resistant Staphylococcus aureus infections.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Therapy, Combination; Gentamicins; Huma | 2009 |
Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studies.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Disease Models, Animal; Drug Inte | 2009 |
Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Apoptosis; Disease Models, Animal; Drug Interactions; | 2011 |
Combination antibiotic therapy of bacterial endocarditis.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Therapy, Combination; | 1980 |
Experimental foreign body infection in mice.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Disease Models, Animal; Foreign Bodies; Gentam | 1993 |
Heat-shock proteins in animal models for acute renal failure.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Constriction; | 1995 |
Local treatment of bone and soft tissue infections with the collagen-gentamicin sponge.
Topics: Animals; Anti-Bacterial Agents; Collagen; Controlled Clinical Trials as Topic; Disease Models, Anima | 1997 |
Aminoglycoside ototoxicity: prevention in sight?
Topics: Animals; Anti-Bacterial Agents; Antitubercular Agents; Clinical Trials as Topic; Cochlea; Disease Mo | 1998 |
A review. Lessons from an animal model of intra-abdominal sepsis.
Topics: Abdomen; Abscess; Animals; Anti-Bacterial Agents; Bacteroides fragilis; Barium Sulfate; Cecum; Clind | 1978 |
Cyclosporine nephrotoxicity.
Topics: Animals; Blood Pressure; Cyclosporins; Disease Models, Animal; Gentamicins; Glomerular Filtration Ra | 1986 |
Cyclosporine: toxicity, metabolism, and drug interactions--implications from animal studies.
Topics: Animals; Cyclosporins; Disease Models, Animal; Dogs; Drug Interactions; Gentamicins; Humans; Ketocon | 1985 |
Experimental models of nephrotoxic acute renal failure.
Topics: Acute Kidney Injury; Animals; Capillary Permeability; Cisplatin; Disease Models, Animal; Dogs; Genta | 1985 |
The pathogenesis of infections owing to Pseudomonas aeruginosa using the burned mouse model: experimental studies from the Shriners Burns Institute, Cincinnati.
Topics: ADP Ribose Transferases; Animals; Bacterial Toxins; Burns; Disease Models, Animal; Endopeptidases; E | 1985 |
Pseudomonas aeruginosa infections.
Topics: Animals; Antibodies, Bacterial; Antineoplastic Agents; Arthritis, Infectious; Bone Diseases; Burns; | 1972 |
[Experimental pyelonephritis, chemotherapeutic studies (review of the literature)].
Topics: Acute Disease; Ampicillin; Animals; Anti-Bacterial Agents; Chloramphenicol; Chronic Disease; Coryneb | 1971 |
3 trials available for gentamicin and Disease Models, Animal
| Article | Year |
|---|---|
Calcium dobesilate for prevention of gentamicin-induced nephrotoxicity in rats.
Topics: Animals; Blood Urea Nitrogen; Calcium Dobesilate; Creatinine; Disease Models, Animal; Ferric Compoun | 2014 |
[Microbiological and pharmacological parameters as evaluation criteria for chemotherapeutics].
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Biopharmaceutics; Cephalosporins; Clinical Tri | 1977 |
[Experimental and clinical study of nitazol as an antibacterial drug in the complex treatment of peritonitis].
Topics: Animals; Anti-Infective Agents; Child; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Th | 1990 |
458 other studies available for gentamicin and Disease Models, Animal
| Article | Year |
|---|---|
Protective Effect of Honey and Propolis against Gentamicin-Induced Oxidative Stress and Hepatorenal Damages.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gentamicins; Honey; Kidney; | 2021 |
Topics: Animals; Antibodies, Bacterial; Bacterial Load; Colony Count, Microbial; Cystitis; Disease Models, A | 2021 |
The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; | 2021 |
In vitro investigations of Staphylococcus aureus biofilms in physiological fluids suggest that current antibiotic delivery systems may be limited.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Gentamicins; Staphylococcal Infect | 2022 |
Characterization of novel bacteriophage PSKP16 and its therapeutic potential against β-lactamase and biofilm producer strain of K2-Hypervirulent Klebsiella pneumoniae pneumonia infection in mice model.
Topics: Animals; Bacteriophages; Biofilms; Disease Models, Animal; Gentamicins; Inflammation; Klebsiella pne | 2023 |
Combination of Azithromycin and Gentamicin for Efficient Treatment of Pseudomonas aeruginosa Infections.
Topics: Animals; Anti-Bacterial Agents; Azithromycin; Disease Models, Animal; Drug Therapy, Combination; Dru | 2019 |
Reno-protective effect of linagliptin against gentamycin nephrotoxicity in rats.
Topics: Adamantane; Animals; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease | 2019 |
Does the induced membrane have antibacterial properties? An experimental rat model of a chronic infected nonunion.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Bone Cements; Bone Transplantation; Chronic | 2020 |
Nephron loss detected by MRI following neonatal acute kidney injury in rabbits.
Topics: Acute Kidney Injury; Animals; Animals, Newborn; Cations; Disease Models, Animal; Ferritins; Gentamic | 2020 |
Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice.
Topics: Animals; Anti-Bacterial Agents; Bacterial Typing Techniques; Brain Neoplasms; Cell Line, Tumor; Dise | 2020 |
Protective effect of Polygonatum sibiricum polysaccharides on gentamicin-induced acute kidney injury in rats via inhibiting p38 MAPK/ATF2 pathway.
Topics: Activating Transcription Factor 2; Acute Kidney Injury; Animals; Biomarkers; Biopsy; Blood Chemical | 2020 |
Preclinical evaluation of efficacy and pharmacokinetics of gentamicin containing extracellular-matrix envelope.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Extracellular Matrix; Gentamicins; Pacemaker | 2020 |
Impaired Tubular Reabsorption Is the Main Mechanism Explaining Increases in Urinary NGAL Excretion Following Acute Kidney Injury in Rats.
Topics: Acute Kidney Injury; Animals; Biomarkers; Cisplatin; Disease Models, Animal; Gentamicins; Kidney Tub | 2020 |
Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity.
Topics: Animals; Cytokines; Disease Models, Animal; Gentamicins; Inflammation; Inflammation Mediators; Kidne | 2020 |
Mapping vascular and glomerular pathology in a rabbit model of neonatal acute kidney injury using MRI.
Topics: Acute Kidney Injury; Animals; Animals, Newborn; Disease Models, Animal; Gentamicins; Indomethacin; K | 2020 |
Pharmacological read-through of R294X Mecp2 in a novel mouse model of Rett syndrome.
Topics: Animals; Brain; Disease Models, Animal; Gentamicins; Humans; Methyl-CpG-Binding Protein 2; Mice; Mut | 2020 |
Nephroprotective effects of Datura metel extract in gentamicin induced mice model: biochemical and histological evidences.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Datura metel; Disease Models, Animal; Female; Gentamicins; | 2020 |
Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Disease Models, Animal; Gentamicins; Imidazoles; Indo | 2020 |
Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cytokines; | 2021 |
Bacteriophage-antibiotic combinations against ciprofloxacin/ceftriaxone-resistant Escherichia coli in vitro and in an experimental Galleria mellonella model.
Topics: Animals; Anti-Bacterial Agents; Bacteriophages; Biofilms; Ceftriaxone; Ciprofloxacin; Combined Modal | 2020 |
Identification of urinary microRNA biomarkers for
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Biomarkers; Disease Models, Animal; Female; Gen | 2020 |
Urinary microRNAs miR-15b and miR-30a as novel noninvasive biomarkers for gentamicin-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Biomarkers; Disease Models, Animal; Dogs; Gene Expression Regulation; | 2021 |
Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations.
Topics: Animals; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dise | 2020 |
Method used to establish a large animal model of drug-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Cisplatin; Disease Models, Animal; Gentamicins; Male; Swine; Swine, Mi | 2021 |
Local treatment of experimental mandibular osteomyelitis with an injectable biomimetic gentamicin hydrogel using a new rabbit model.
Topics: Animals; Biomimetic Materials; Disease Models, Animal; Drug Carriers; Gentamicins; Hydrogels; Mandib | 2021 |
HPLC-ESI/MS profiling, phytoconstituent isolation and evaluation of renal function, oxidative stress and inflammation in gentamicin-induced nephrotoxicity in rats of Ficus spragueana Mildbr. & Burret.
Topics: Acute Kidney Injury; Animals; Antioxidants; Chromatography, High Pressure Liquid; Disease Models, An | 2021 |
Development of an experimental model for ocular toxicity screening in Zebrafish.
Topics: Animals; Anti-Bacterial Agents; Digoxin; Disease Models, Animal; Enzyme Inhibitors; Gentamicins; Tox | 2021 |
Intratympanic Lipopolysaccharide Elevates Systemic Fluorescent Gentamicin Uptake in the Cochlea.
Topics: Animals; Cochlea; Cytokines; Disease Models, Animal; Gentamicins; Injection, Intratympanic; Lipopoly | 2021 |
Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect.
Topics: Animals; Anti-Bacterial Agents; Bone and Bones; Bone Regeneration; Disease Models, Animal; Drug Deli | 2021 |
Correlation between urinary KIM-1 and kidney protein expression of p-ERK following damage in rats exposed to gentamicin or lead acetate.
Topics: Acute Kidney Injury; Animals; Calcium Channels; Cation Transport Proteins; Cell Adhesion Molecules; | 2021 |
The Nephroprotective Effect of
Topics: Acute Kidney Injury; Animals; Cytoprotection; Disease Models, Animal; Fruit; Gentamicins; Kidney; Pl | 2021 |
Key role of oxidative stress in animal models of aminoglycoside nephrotoxicity revealed by a systematic analysis of the antioxidant-to-nephroprotective correlation.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Catalase; Disease Models, Animal; Gentamicins; | 2017 |
Protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss.
Topics: Animals; Cochlea; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Gentamicins; Guin | 2017 |
Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; D | 2018 |
Ultrahigh dose gentamicin alters inflammation and angiogenesis in vivo and in vitro.
Topics: Animals; Anti-Bacterial Agents; Burns; Cell Proliferation; Disease Models, Animal; Dose-Response Rel | 2017 |
Deferiprone and Gallium-Protoporphyrin Have the Capacity to Potentiate the Activity of Antibiotics in
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Bacterial Load; Biofilms; Caenorhabditis el | 2017 |
Novel porcine model for calcium oxalate stone formation.
Topics: Ammonium Chloride; Animals; Blood Urea Nitrogen; Calcium Oxalate; Citric Acid; Creatinine; Disease M | 2017 |
Protective effect of alpha-linolenic acid on gentamicin-induced ototoxicity in mice.
Topics: Accidental Falls; alpha-Linolenic Acid; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ap | 2017 |
Altered gene expression profile in a rat model of gentamicin-induced ototoxicity and nephrotoxicity, and the potential role of upregulated Ifi44 expression.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Cytoskeletal Proteins; Disease Models, Animal; Ear, Inner; | 2017 |
Anticonvulsant effect of gentamicin on the seizures induced by kainic acid.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2018 |
Protective Effects of Pomegranate Juice on Nephrotoxicity Induced by Captopril and Gentamicin in Rats.
Topics: Animals; Biomarkers; Captopril; Cytoprotection; Disease Models, Animal; Fruit and Vegetable Juices; | 2017 |
Transcriptomic analysis of chicken cochleae after gentamicin damage and the involvement of four signaling pathways (Notch, FGF, Wnt and BMP) in hair cell regeneration.
Topics: Animals; Animals, Newborn; Bone Morphogenetic Proteins; Cell Differentiation; Cell Proliferation; Ch | 2018 |
Gentamicin-intercalated smectite as a new therapeutic option for Helicobacter pylori eradication.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Feces; Gastric Mucosa; Gentamicins; Helicoba | 2018 |
Alteration of renal excretion pathways in gentamicin-induced renal injury in rats.
Topics: Acute Kidney Injury; Animals; Antiporters; ATP Binding Cassette Transporter, Subfamily G, Member 2; | 2018 |
Local application of a gentamicin-loaded thermo-responsive hydrogel allows for fracture healing upon clearance of a high Staphylococcus aureus load in a rabbit model.
Topics: Acrylic Resins; Animals; Bacterial Load; Biomechanical Phenomena; Disease Models, Animal; Female; Fr | 2018 |
A new class of synthetic retinoid antibiotics effective against bacterial persisters.
Topics: Animals; Anti-Bacterial Agents; Benzoates; Caenorhabditis elegans; Cell Death; Cell Line; Disease Mo | 2018 |
Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Delivery Systems; Esch | 2018 |
Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Carriers; Gentamicins; Klebsiella Infec | 2018 |
Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss.
Topics: Animals; Cell Survival; Disease Models, Animal; Gentamicins; Hair Cells, Auditory; Hearing Loss; Lip | 2018 |
Mechanisms Underlying Exacerbation of Osmotic Nephrosis Caused by Pre-existing Kidney Injury.
Topics: Acute Kidney Injury; Animals; Dextrans; Disease Models, Animal; Disease Progression; Female; Gentami | 2018 |
Intra-articular Gentamicin-loaded PLA Microparticle Injection for the Treatment of Septic Arthritis in Rabbits.
Topics: Animals; Anti-Bacterial Agents; Arthritis, Infectious; Bacterial Load; Disease Models, Animal; Drug | 2018 |
Protective effect of Rotula aquatica Lour against gentamicin induced oxidative stress and nephrotoxicity in Wistar rats.
Topics: Animals; Antioxidants; Biomarkers; Boraginaceae; Cytoprotection; Disease Models, Animal; Enzymes; Fe | 2018 |
Effective Treatment of Chronic Proliferative Cholangitis by Local Gentamicin Infusion in Rabbits.
Topics: Animals; Anti-Bacterial Agents; Asia, Eastern; Bile Ducts; Bile Ducts, Intrahepatic; Cholangitis; Di | 2018 |
Natural Derived Surfactant Preparation As a Carrier of Polymyxin E for Treatment of Pseudomonas aeruginosa Pneumonia in a Near-Term Rabbit Model.
Topics: Animals; Anti-Bacterial Agents; Biological Products; Colistin; Disease Models, Animal; Drug Carriers | 2019 |
Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?
Topics: Animals; Auditory Threshold; Contrast Media; Disease Models, Animal; Ear, Inner; Ear, Middle; Endoly | 2018 |
Comparative Activity of Ceftriaxone, Ciprofloxacin, and Gentamicin as a Function of Bacterial Growth Rate Probed by Escherichia coli Chromosome Replication in the Mouse Peritonitis Model.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Ciprofloxacin; Disease Models, Animal; Escherichia coli | 2019 |
Establishment of a Gentamicin Cochlear Poisoning Model in Guinea Pigs and Cochlear Nerve Endings Recognition of Ultrasound Signals.
Topics: Animals; Cochlea; Cochlear Nerve; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; F | 2018 |
A multiplexed UPLC-MS/MS assay for the simultaneous measurement of urinary safety biomarkers of drug-induced kidney injury and phospholipidosis.
Topics: Acute Kidney Injury; Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Gentamicin | 2019 |
Enhancing the antibacterial efficacy of low-dose gentamicin with 5 minute assistance of photothermy at 50 °C.
Topics: Animals; Anti-Bacterial Agents; Cell Proliferation; Cell Survival; Disease Models, Animal; Disulfide | 2019 |
An in vitro biofilm model of Staphylococcus aureus infection of bone.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Cattle; Daptomycin; Disease Models, Animal; Femur; Gentami | 2019 |
The effect of hemorrhagic shock and intraosseous adrenaline injection on the delivery of a subsequently administered drug - an experimental study.
Topics: Animals; Anti-Bacterial Agents; Cardiopulmonary Resuscitation; Disease Models, Animal; Epinephrine; | 2019 |
Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Klebsiella Infections; Klebsiel | 2019 |
Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Bone and Bones; Calcium Carbonate; Calcium | 2019 |
Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis.
Topics: Animals; Anti-Bacterial Agents; Antithrombins; Aortic Valve; Bacterial Load; Chemotherapy, Adjuvant; | 2019 |
Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations.
Topics: Animals; Codon, Nonsense; Disease Models, Animal; Factor IX; Gentamicins; Hemophilia A; Humans; Live | 2019 |
Potential protective effects of Dapagliflozin in gentamicin induced nephrotoxicity rat model via modulation of apoptosis associated miRNAs.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzhydryl Compounds; Disease Models, Animal; Gene Expressi | 2019 |
Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss.
Topics: Aminoglycosides; Animals; Calcium; Cell Survival; Cells, Cultured; Disease Models, Animal; Gene Expr | 2019 |
A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant
Topics: Animals; Anti-Bacterial Agents; Bithionol; Cell Membrane; Cell Membrane Permeability; Cholesterol; D | 2019 |
Treatment with gentamicin on a murine model of protothecal mastitis.
Topics: Animals; Anti-Infective Agents; Cell Count; Disease Models, Animal; Female; Gentamicins; Histocytoch | 2013 |
Study on therapeutic action of bone marrow derived mesenchymal stem cell combined with vitamin E against acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Bone Marrow Cells; Cell | 2013 |
Early vancomycin, amikacin and gentamicin concentrations in pulmonary artery and pulmonary tissue are not affected by VA ECMO (venoarterial extracorporeal membrane oxygenation) in a pig model of prolonged cardiac arrest.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Disease Models, Animal; Extracorporeal Membrane Oxygenatio | 2013 |
Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis.
Topics: Administration, Oral; Anesthetics, Local; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; | 2013 |
Gentamicin-induced bilateral vestibulopathy in rabbits: vestibular dysfunction and histopathology.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Rabbits; Vestibular Diseases | 2013 |
Histone deacetylase inhibitor enhances recovery after AKI.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fibrosis; Gentamicins; Histone Deacetylase 1; | 2013 |
Gentamicin-loaded borate bioactive glass eradicates osteomyelitis due to Escherichia coli in a rabbit model.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Borates; Ceramics; Delayed-Action Preparati | 2013 |
Local antibiotic delivery by a bioabsorbable gel is superior to PMMA bead depot in reducing infection in an open fracture model.
Topics: Absorbable Implants; Administration, Topical; Animals; Anti-Bacterial Agents; Disease Models, Animal | 2014 |
Inner ear insult ablates the arousal response to hypoxia and hypercarbia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Bacterial Agents; Arousal; Disease Models, Ani | 2013 |
Ethanolic extract of garlic for attenuation of gentamicin-induced nephrotoxicity in Wistar rats.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Creatinine; Disease Models | 2013 |
Gentamicin conditioning confers auditory protection against noise trauma.
Topics: Acoustic Stimulation; Animals; Anti-Bacterial Agents; Auditory Threshold; Cochlea; Disease Models, A | 2014 |
Activities of fosfomycin and rifampin on planktonic and adherent Enterococcus faecalis strains in an experimental foreign-body infection model.
Topics: Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Calorimetry; D | 2014 |
Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets.
Topics: Amino Acids; Ampicillin; Animals; Animals, Newborn; Anti-Bacterial Agents; Antibiotic Prophylaxis; D | 2014 |
Protective effect of selected calcium channel blockers and prednisolone, a phospholipase-A2 inhibitor, against gentamicin and carbon tetrachloride-induced nephrotoxicity.
Topics: Animals; Antioxidants; Biomarkers; Calcium Channel Blockers; Carbon Tetrachloride; Cytoprotection; D | 2014 |
Immunotherapeutics to prevent the replication of Brucella in a treatment failure mouse model.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Outer Membrane Proteins; Brucella; | 2014 |
Identification of point mutations in clinical Staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Genome, Bacterial; Gentamicins; Mice; Microb | 2014 |
Dynamic distribution of ototoxic gentamicin entry into inner hair cells of mice.
Topics: Alcohol Oxidoreductases; Animals; Anti-Bacterial Agents; Co-Repressor Proteins; Disease Models, Anim | 2014 |
Therapeutic potential of the antimicrobial peptide OH-CATH30 for antibiotic-resistant Pseudomonas aeruginosa keratitis.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cation | 2014 |
Jellyfish model for ototoxicity.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ear Diseases; Gentamicins; Hair C | 2015 |
Increased Tbx1 expression may play a role via TGFβ-Smad2/3 signaling pathway in acute kidney injury induced by gentamicin.
Topics: Acute Kidney Injury; Animals; Apoptosis; Biomarkers; Blood Urea Nitrogen; Caspase 3; Disease Models, | 2014 |
Effects of SertaSil on wound healing in the rat.
Topics: Abscess; Administration, Topical; Animals; Calcium Chloride; Disease Models, Animal; Drug Evaluation | 2014 |
Local gentamicin delivery from resorbable viscous hydrogels is therapeutically effective.
Topics: Absorbable Implants; Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Blood Urea Nitrog | 2015 |
Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Complex Mixtures; Disease Model | 2014 |
Spontaneous and Partial Repair of Ribbon Synapse in Cochlear Inner Hair Cells After Ototoxic Withdrawal.
Topics: Action Potentials; Animals; Cochlea; Disease Models, Animal; Ear Diseases; Evoked Potentials, Audito | 2015 |
Coating with a novel gentamicinpalmitate formulation prevents implant-associated osteomyelitis induced by methicillin-susceptible Staphylococcus aureus in a rat model.
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Coated Materials, Biocompatible; Disease Mod | 2015 |
Beetroot (Beta vulgaris L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model.
Topics: Animals; Apoptosis; Arab World; Beta vulgaris; Catalase; Cytokines; Disease Models, Animal; Female; | 2014 |
ECG in neonate mice with spinal muscular atrophy allows assessment of drug efficacy.
Topics: Animals; Animals, Newborn; Biomarkers; Bradycardia; Disease Models, Animal; Drug Evaluation, Preclin | 2015 |
Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague.
Topics: Acyltransferases; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Adhesion; Bacteri | 2015 |
Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Autophagy; Disease Models, Animal; Genta | 2015 |
Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene.
Topics: Alleles; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Fibroblasts; Ge | 2015 |
Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Cochlea; Disease Models, Animal; Epithelium; Gentam | 2015 |
Efficacy of liposomal gentamicin against Rhodococcus equi in a mouse infection model and colocalization with R. equi in equine alveolar macrophages.
Topics: Actinomycetales Infections; Animals; Anti-Bacterial Agents; Clarithromycin; Disease Models, Animal; | 2015 |
Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Biomarkers; Cisplatin; Disease Models, Animal; | 2015 |
The effect of radiotherapy on gentamicin ototoxicity: an animal model.
Topics: Animals; Biopsy, Needle; Cochlea; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Res | 2015 |
Hybrid wound dressings with controlled release of antibiotics: Structure-release profile effects and in vivo study in a guinea pig burn model.
Topics: Animals; Anti-Bacterial Agents; Bandages; Biocompatible Materials; Burns; Delayed-Action Preparation | 2015 |
Paradoxical effects of atorvastatin on renal tubular cells: an experimental investigation.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blood Urea Nitrogen; Creatinine; Disease Models, An | 2015 |
Biodegradable soy wound dressings with controlled release of antibiotics: Results from a guinea pig burn model.
Topics: Animals; Anti-Bacterial Agents; Bandages; Biocompatible Materials; Burns; Delayed-Action Preparation | 2015 |
Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Apoptosis; Autophagy; Disease Models, Animal; G | 2015 |
[Prophylaxis of purulent complications in mechanical ileus].
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Biological Transport; Cephalosporins; Ciprofloxacin; Dis | 2015 |
Transcription profile of genes affected in response to pathological changes in drug-induced rat model of acute kidney injury.
Topics: Acute Kidney Injury; Animals; Biomarkers; Bone Morphogenetic Protein 7; Cell Adhesion Molecules; Dis | 2015 |
N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model.
Topics: Acetylcysteine; Animals; Cochlea; Disease Models, Animal; Ear Diseases; Evoked Potentials, Auditory, | 2015 |
Efficacy of Primary Collagen Cross-Linking with Photoactivated Chromophore (PACK-CXL) for the Treatment of Staphylococcus aureus-Induced Corneal Ulcers.
Topics: Animals; Anti-Bacterial Agents; Cefazolin; Chloramphenicol; Collagen; Colony Count, Microbial; Corne | 2015 |
[Effect of probiotic product containing bifidobacteria and biogel from brown algae on the intestinal microflora and parameters of innate immunity in mice with experimental drug dysbacteriosis].
Topics: Animals; Bifidobacterium; Disease Models, Animal; Dysbiosis; Gels; Gentamicins; Immunity, Innate; In | 2015 |
Dressing with epigallocatechin gallate nanoparticles for wound regeneration.
Topics: Animals; Anti-Bacterial Agents; Bandages; Biocompatible Materials; Catechin; Cells, Cultured; Chitos | 2016 |
FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number.
Topics: Acoustic Stimulation; Alcohol Oxidoreductases; Animals; Auditory Threshold; Co-Repressor Proteins; D | 2016 |
Alteration of Masquelet's induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat's femur.
Topics: Animals; Anti-Bacterial Agents; Bone Cements; Clindamycin; Disease Models, Animal; Femoral Fractures | 2016 |
Enteral but not parenteral antibiotics enhance gut function and prevent necrotizing enterocolitis in formula-fed newborn preterm pigs.
Topics: Ampicillin; Animals; Animals, Newborn; Anti-Bacterial Agents; Biological Availability; Disease Model | 2016 |
Full-thickness porcine burns infected with Staphylococcus aureus or Pseudomonas aeruginosa can be effectively treated with topical antibiotics.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Burns; Debridement; Disease Models, Animal; | 2016 |
Enhanced renoprotective effect of IGF-1 modified human umbilical cord-derived mesenchymal stem cells on gentamicin-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Antigens, Surface; Antioxidants; Apoptosis; Biomarkers; Cell Movement; | 2016 |
Alleviation of renal mitochondrial dysfunction and apoptosis underlies the protective effect of sitagliptin in gentamicin-induced nephrotoxicity.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; | 2016 |
Effects of Memantine on Aminoglycoside-Induced Apoptosis of Spiral Ganglion Cells in Guinea Pigs.
Topics: Animals; Apoptosis; Blotting, Western; Cochlea; Disease Models, Animal; Gentamicins; Guinea Pigs; In | 2016 |
Establishing a rat model for the study of vitamin K deficiency.
Topics: Animals; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Diet; Disease Models | 2016 |
Increased Effects of Extracorporeal Shock Waves Combined with Gentamicin against Staphylococcus aureus Biofilms In Vitro and In Vivo.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Combined Modality Therapy; Disease Models, Animal; Extraco | 2016 |
[INTESTINAL FAILURE AND YERSINIA PSEUDOTUBERCULOSIS TRANSLOCATION IN THE DEVELOPMENTOF EXPERIMENTAL GENERALIZED INFECTION].
Topics: Animals; Anti-Bacterial Agents; Bacterial Translocation; Disease Models, Animal; Gentamicins; Intest | 2016 |
A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections.
Topics: Animals; Bacterial Load; Biofilms; Cell Line; Cystic Fibrosis; Disease Models, Animal; Epithelial Ce | 2016 |
Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model.
Topics: Acrylic Resins; Animals; C-Reactive Protein; Collagen; Disease Models, Animal; Drug Liberation; Elas | 2016 |
Disruption of Membrane by Colistin Kills Uropathogenic Escherichia coli Persisters and Enhances Killing of Other Antibiotics.
Topics: Animals; Anti-Bacterial Agents; Cell Membrane; Colistin; Disease Models, Animal; Dose-Response Relat | 2016 |
Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model.
Topics: Animals; Biomarkers; Body Weight; Diagnostic Tests, Routine; Disease Models, Animal; Drinking Water; | 2016 |
Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression.
Topics: Animals; beta Catenin; Cell Proliferation; Cytoprotection; Disease Models, Animal; Epoetin Alfa; Gen | 2017 |
Fosfomycin Addition to Poly(D,L-Lactide) Coating Does Not Affect Prophylaxis Efficacy in Rat Implant-Related Infection Model, But That of Gentamicin Does.
Topics: Animals; Antibiotic Prophylaxis; Bone Wires; Coated Materials, Biocompatible; Disease Models, Animal | 2016 |
The Effect of Nystatin Solution on Otoacoustic Emissions in Rats.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Cochlea; Disease Models, Animal; Ear, Middle; Gen | 2017 |
Pimpinella anisum L. ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats.
Topics: Animals; Antioxidants; Biomarkers; Disease Models, Animal; Ethanol; Gentamicins; Kidney; Kidney Dise | 2017 |
Study the therapeutic mechanism of Amomum compactum in gentamicin-induced acute kidney injury rat based on a back propagation neural network algorithm.
Topics: Acute Kidney Injury; Amomum; Animals; Anti-Bacterial Agents; Biomarkers; Chromatography, High Pressu | 2017 |
Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Creatinine; Cytoprotection; Dipyridamole; Disease Mod | 2017 |
Therapeutic value of nerve growth factor in promoting neural stem cell survival and differentiation and protecting against neuronal hearing loss.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Cochle | 2017 |
Cochlear and Vestibular Effects of Combined Intratympanic Gentamicin and Dexamethasone.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Dexamethasone; Disease Models, Animal; Evoked Potentials, A | 2017 |
Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Dis | 2008 |
Time course of apoptotic cell death in guinea pig cochlea following intratympanic gentamicin application.
Topics: Administration, Topical; Animals; Apoptosis; Cell Survival; Disease Models, Animal; DNA Fragmentatio | 2008 |
Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa.
Topics: Aminoglycosides; Animals; Carrier Proteins; cis-trans-Isomerases; Codon, Nonsense; Disease Models, A | 2008 |
Polyethylene glycol influences microbial interactions with intestinal epithelium.
Topics: Animals; Caco-2 Cells; Candida albicans; Candida glabrata; Candidiasis; Disease Models, Animal; Esch | 2009 |
Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Decanoic Acids; Disease Models, Animal; Dru | 2008 |
Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease.
Topics: Adaptor Proteins, Signal Transducing; Animals; Chlorocebus aethiops; Codon, Nonsense; COS Cells; Dis | 2008 |
Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Culture Techniques; C | 2009 |
Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices.
Topics: Acetylcysteine; Amphotericin B; Animals; Anti-Bacterial Agents; Coated Materials, Biocompatible; Dis | 2009 |
The expression of NOB1 in spiral ganglion cells of guinea pig.
Topics: Animals; Deafness; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Gentamicins; Gui | 2009 |
Ototoxic effects of single-dose versus 19-day daily-dose gentamicin.
Topics: Animals; Auditory Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administ | 2008 |
Differences in Ototoxicity across Species.
Topics: Animals; Auditory Threshold; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2008 |
Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model.
Topics: Amino Acid Substitution; Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 2009 |
[Bacterial corneal ulcer treated with intrastromal antibiotic. Experimental model in vivo].
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cornea; | 2009 |
Microbial tolerance in secondary peritonitis is dose dependent.
Topics: Animals; Anti-Bacterial Agents; Cytokines; Disease Models, Animal; Gentamicins; Klebsiella Infection | 2009 |
Better prophylaxis against surgical site infection with local as well as systemic antibiotics. An in vivo study.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antibiotic Prophylaxis; Cefazolin; Dis | 2009 |
Better prophylaxis against surgical site infection with local as well as systemic antibiotics. An in vivo study.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antibiotic Prophylaxis; Cefazolin; Dis | 2009 |
Better prophylaxis against surgical site infection with local as well as systemic antibiotics. An in vivo study.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antibiotic Prophylaxis; Cefazolin; Dis | 2009 |
Better prophylaxis against surgical site infection with local as well as systemic antibiotics. An in vivo study.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antibiotic Prophylaxis; Cefazolin; Dis | 2009 |
Increased urinary losses of carnitine and decreased intramitochondrial coenzyme A in gentamicin-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Blood Urea Nitrogen; Carnitine; Coenzyme A; Cr | 2010 |
Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways.
Topics: Analysis of Variance; Animals; Atorvastatin; Chi-Square Distribution; Disease Models, Animal; Free R | 2009 |
Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice.
Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Cochlea; Disease Models, Animal; Dose-Res | 2010 |
The modifier protein of glyceraldehyde-3-phosphate dehydrogenase reduces free radical-mediated renal damage in a rat model of acute kidney injury.
Topics: Acute Disease; Animals; Chlorocebus aethiops; Creatinine; Disease Models, Animal; Epithelial Cells; | 2010 |
Nephroprotective effect of Withania somnifera: a dose-dependent study.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Disease Models, Animal; Gentamicins; Kidney; Kidney Di | 2009 |
Physiological dimensions of ototoxic responses in a model fish species.
Topics: Acoustic Stimulation; Acoustics; Animals; Audiometry; Auditory Threshold; Disease Models, Animal; Dr | 2010 |
Impact of gentamicin-supplemented polyvinylidenfluoride mesh materials on MMP-2 expression and tissue integration in a transgenic mice model.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Disease Models, Animal; Foreign-Body Reacti | 2010 |
Nanofiber micro-dispersed oxidized cellulose as a carrier for topical antimicrobials: first experience.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Bacterial Infections; Cellulose, Oxi | 2010 |
The effect of topical Castellani solution on outer hair cell function of rats.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Disease Models, Animal; Ear, Middle; Follow | 2010 |
The nephroprotective effects of pioglitazone and glibenclamide against gentamicin-induced nephrotoxicity in rats: a comparative study.
Topics: Animals; Antioxidants; Creatinine; Disease Models, Animal; Gentamicins; Glyburide; Kidney Diseases; | 2010 |
The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Electrolytes; Gentamicins; Microbial Sensiti | 2010 |
Determination of therapeutic equivalence of generic products of gentamicin in the neutropenic mouse thigh infection model.
Topics: Animals; Anti-Infective Agents; Bacterial Infections; Disease Models, Animal; Drugs, Generic; Gentam | 2010 |
[Effect of Liuwei Dihuang pill on expression of NF-kappaB in kidney lesion induced by gentamicin in rats].
Topics: Animals; Blotting, Western; Disease Models, Animal; Drugs, Chinese Herbal; Gentamicins; Kidney; Kidn | 2010 |
Intravenous cell therapy for acute renal failure with serum amyloid A protein-reprogrammed cells.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Transplantation; Cispla | 2010 |
Sub-nephrotoxic doses of gentamicin predispose animals to developing acute kidney injury and to excrete ganglioside M2 activator protein.
Topics: Acute Kidney Injury; Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; | 2010 |
Intravenous microinjections of zebrafish larvae to study acute kidney injury.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Gentamicins; Injections, Intravenous; | 2010 |
The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model.
Topics: Absorbable Implants; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Carriers; Femoral | 2010 |
Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity.
Topics: Acute Disease; Animals; Biomarkers; Chronic Disease; Disease Models, Animal; Gentamicins; Kidney Dis | 2010 |
Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Camellia sinensis; Carbohydrate Metabolism; Creatinine | 2010 |
Bacteriophage versus antimicrobial agents for the treatment of murine burn wound infection caused by Klebsiella pneumoniae B5055.
Topics: Administration, Topical; Animals; Anti-Infective Agents; Bacteriophages; Burns; Complementary Therap | 2011 |
Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.
Topics: Animals; Cell Death; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Female; Gentam | 2010 |
[Experimental sensorineural loss of hearing of ototoxic origin in animals: apoptotic mechanism of cell death in the spiral organ].
Topics: Animals; Apoptosis; Disease Models, Animal; Gentamicins; Hearing Loss, Sensorineural; Immobilization | 2010 |
Protective role of Pleurotus porrigens (Angel's wings) against gentamicin-induced nephrotoxicty in mice.
Topics: Animals; Biomarkers; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Gentamicins; Injection | 2010 |
Novel biodegradable composite wound dressings with controlled release of antibiotics: results in a guinea pig burn model.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Biocompatible Materials; Burns; Contracture; D | 2011 |
Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Blotting, Western; Caspases; Cell Line; Cochlea; Disease | 2011 |
Antibacterial and dermal toxicological profiles of ethyl acetate extract from Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae).
Topics: Animals; Anti-Bacterial Agents; Asteraceae; Dermatitis; Disease Models, Animal; Female; Gentamicins; | 2011 |
Pharmacological enhancement of ex vivo gene therapy neuroprotection in a rodent model of retinal degeneration.
Topics: Animals; Cell Count; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Embryonic Ste | 2012 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.
Topics: Acceleration; Animals; Disease Models, Animal; Electric Stimulation; Eye Movements; Female; Gentamic | 2011 |
Potentiation of pro-inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Dose-Response Relationship | 2011 |
Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice.
Topics: Allium; Animals; Disease Models, Animal; Gentamicins; Humans; Kidney Diseases; Male; Mice; Plant Ext | 2012 |
Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Gentamicins; Hair Cells, Auditory; Hearing Loss, | 2011 |
Apoptosis-inducing factor is involved in gentamicin-induced vestibular hair cell death.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Cell Survival; C | 2012 |
Ototoxicity of intratympanic docusate sodium and mineral oil in the guinea pig.
Topics: Animals; Auditory Threshold; Cerumen; Cerumenolytic Agents; Dioctyl Sulfosuccinic Acid; Disease Mode | 2012 |
Aerosolized gentamicin reduces the burden of tuberculosis in a murine model.
Topics: Administration, Inhalation; Animals; Antitubercular Agents; Bacterial Load; Disease Models, Animal; | 2012 |
Fibrin glue with gentamicin as an alternative to conventional surgery in experimental treatment of duodenal fistula in rats.
Topics: Abdominal Wound Closure Techniques; Animals; Anti-Bacterial Agents; Biomechanical Phenomena; Disease | 2012 |
Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Disease Progression; Fatty Acids; Fatty Acid | 2012 |
Critical appraisal of air pouch infection model in rats.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Disease Models, Animal; Dose-Re | 2012 |
The optimal aminoglycoside and its dosage for the treatment of severe Enterococcus faecalis infection. An experimental study in the rabbit endocarditis model.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Bacterial Load; Disease Models, Animal; Drug Administratio | 2012 |
Beneficial effects of calcium oral coadministration in gentamicin-induced nephrotoxicity in rats.
Topics: Acute Kidney Injury; Administration, Oral; Animals; Calcium; Dietary Supplements; Disease Models, An | 2012 |
Frequency perception and cell injury in the semicircular canal caused by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gentamicin | 2011 |
Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Weste | 2012 |
Salmonella transiently reside in luminal neutrophils in the inflamed gut.
Topics: Animals; Bacterial Proteins; Cell Movement; Colitis; Disease Models, Animal; Genomic Islands; Gentam | 2012 |
Intestinal motility in acute uremia and effects of erythropoietin.
Topics: Acute Disease; Animals; Colon; Creatinine; Disease Models, Animal; Duodenum; Erythropoietin; Female; | 2012 |
Kidney injury and cell therapy: Preclinical study.
Topics: Animals; Anti-Bacterial Agents; Cell- and Tissue-Based Therapy; Disease Models, Animal; Gentamicins; | 2012 |
Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia.
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacterial Load; Bacterial Vaccines; Disease | 2012 |
Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy.
Topics: Animals; Codon, Nonsense; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2012 |
A modified model of gentamicin induced renal failure in rats: toxicological effects of the iodinated X-ray contrast media ioversol and potential usefulness for toxicological evaluation of iodinated X-ray contrast media.
Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Dose-Response Relationship, Dr | 2013 |
Antioxidant treatment with coenzyme Q-ter in prevention of gentamycin ototoxicity in an animal model.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Disease Models, Animal; Gentamicins; Guinea Pigs; Hair | 2012 |
Gentamicin affects connexin 26 expression in the cochlear lateral wall.
Topics: Animals; Cochlea; Connexin 26; Connexins; Disease Models, Animal; Gentamicins; Hearing Loss; Injecti | 2012 |
The effect of topically applied antimycotic agents on inner ear vestibular and cochlear function.
Topics: Animals; Antifungal Agents; Clotrimazole; Cochlea; Disease Models, Animal; Ear, Inner; Evoked Potent | 2013 |
Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Blood Urea Nitrogen; Creatinine; Cytoprotection; D | 2012 |
A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2.
Topics: Animals; Anti-Bacterial Agents; Capillary Permeability; Disease Models, Animal; Gentamicins; Glomeru | 2012 |
Treatment of a methylmalonyl-CoA mutase stopcodon mutation.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Cell Line; Codon, Nonsense; Codon, Terminator; Diseas | 2012 |
New perspectives for natural antimicrobial peptides: application as antinflammatory drugs in a murine model.
Topics: Administration, Intravenous; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Anti-Infective Age | 2012 |
Pomegranate extract attenuates gentamicin-induced nephrotoxicity in rats by reducing oxidative stress.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Biopsy, Needle; Chi-Square Distribution; Disease | 2013 |
Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance.
Topics: Animals; Bacterial Translocation; Blotting, Western; Carbon Monoxide; Colitis; Disease Models, Anima | 2013 |
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease | 2014 |
Tetracyclines affect prion infectivity.
Topics: Animals; Anti-Bacterial Agents; Brain; Cattle; Creutzfeldt-Jakob Syndrome; Cricetinae; Disease Model | 2002 |
Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calcium; Contrast Media; Disease Models, Animal; Gentamic | 2002 |
Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calcium; Contrast Media; Disease Models, Animal; Gentamic | 2002 |
Middle ear instillation of gentamicin and streptomycin in chinchillas: electrophysiological appraisal of selective ototoxicity.
Topics: Animals; Chinchilla; Cochlea; Disease Models, Animal; Ear, Middle; Electronystagmography; Evoked Pot | 2002 |
Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion.
Topics: Animals; Disease Models, Animal; Female; Gentamicins; Mice; Mice, Inbred C3H; Neutrophils; Phagocyto | 2003 |
The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Biomarkers; Cellulose; Creatinine; Disease Mode | 2003 |
Protective effects of alpha-tocopherol against gentamicin-induced Oto-vestibulo toxicity: an experimental study.
Topics: alpha-Tocopherol; Animals; Auditory Threshold; Disease Models, Animal; Drug Interactions; Drug-Relat | 2003 |
Gentamicin used as an adjunct to GTR.
Topics: Animals; Anti-Bacterial Agents; Bone Matrix; Bone Substitutes; Connective Tissue; Disease Models, An | 2003 |
Relevance of antimicrobial agent-induced endotoxin release from in vitro cultured Escherichia coli and in vivo experimental infection with Gram-negative bacilli.
Topics: Animals; Anti-Bacterial Agents; Cephalosporins; Disease Models, Animal; Endotoxins; Escherichia coli | 2003 |
Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Cytokines; Disease Models, Animal; Gentamicins; Imipenem | 2003 |
Simulation of human gentamicin pharmacokinetics in an experimental Enterococcus faecalis endocarditis model.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Colony Count, Microbial; Disease Models, Animal; E | 2003 |
Study of serum and tissues angiotensin converting enzyme (ACE) activity in rat with gentamicin induced renal toxicity.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Chromatography, High | 2003 |
73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.
Topics: Acetylglucosaminidase; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Binding Sites; Brain; Ca | 2004 |
Plasma protein extravasation and vascular endothelial growth factor expression with endothelial nitric oxide synthase induction in gentamicin-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Blood Proteins; Blotting, Western; Capillary Pe | 2004 |
Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists.
Topics: Acetylglucosaminidase; Aminoglycosides; Animals; Aprotinin; Binding Sites; Cells, Cultured; Cytochro | 2004 |
Persistence of a Staphylococcus aureus small-colony variant under antibiotic pressure in vivo.
Topics: Animals; Anti-Bacterial Agents; Cattle; Cells, Cultured; Cephapirin; Cloning, Molecular; Colony Coun | 2004 |
In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Infective Agents; Disease Models, Animal; Drug Resistance, Bacterial; Drug | 2004 |
In vivo comparison of Dhvar-5 and gentamicin in an MRSA osteomyelitis prevention model.
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Disease Models, Animal; Femur; Gentamicins; | 2004 |
Acute renal failure in zebrafish: a novel system to study a complex disease.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Disease Model | 2005 |
Synergy of HBO2 and a local antibiotic carrier for experimental osteomyelitis due to Staphylococcus aureus in rats.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Carriers; Female; Gentamicins; Osteomye | 2004 |
Treatment of biofilm infections on implants with low-frequency ultrasound and antibiotics.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Cervical Vertebrae; Disease Models, Animal; Escherichia co | 2005 |
[Study on in vivo drug delivery and repairing large segmental infected bony defect with massive reconstituted bovine xenograft aided by calcium phosphate cement drug core].
Topics: Animals; Anti-Bacterial Agents; Bone Cements; Bone Diseases, Infectious; Bone Substitutes; Bone Tran | 2005 |
Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats.
Topics: Animals; Anti-Bacterial Agents; Cefazolin; Collagen; Debridement; Disease Models, Animal; Female; Ge | 2005 |
Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model.
Topics: Animals; Anti-Bacterial Agents; Bone Cements; Calcium Phosphates; Chronic Disease; Disease Models, A | 2005 |
Nitric oxide in gentamicin-induced acute tubular necrosis in rats.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Colorimetry; Disease Models, Animal; Female; Gentamicins | 2005 |
Flavonoid of Drynaria fortunei protects against acute renal failure.
Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Gentamicins; Guinea Pigs; Kidney T | 2005 |
Effect of nephrotoxins on tubulointerstitial injury and NF-kappaB activation in Adriamycin nephropathy.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Ferr | 2005 |
Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Enteroc | 2005 |
Efficacy of fosfomycin + vancomycin or gentamicin in experimental endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA).
Topics: Animals; Disease Models, Animal; Endocarditis, Bacterial; Fosfomycin; Gentamicins; Humans; Methicill | 1989 |
Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis.
Topics: Acute Kidney Injury; Adenoviridae; Animals; Apoptosis; Chemokine CCL2; Disease Models, Animal; Enzym | 2006 |
Preparation of massive anti-infective reconstituted bone xenograft and related studies.
Topics: Animals; Anti-Bacterial Agents; Bone Substitutes; Bone Transplantation; Calcium Phosphates; Cattle; | 2006 |
The effect of erythropoietin on gentamicin-induced auditory hair cell loss.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cells, Cultured; Disease Models, Animal; Erythropoietin; | 2006 |
Renal effects of gentamicin in chronic bile duct ligated rats.
Topics: Animals; Anti-Bacterial Agents; Bile Ducts; Cholestasis; Dinoprostone; Disease Models, Animal; Dose- | 2006 |
Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model.
Topics: Amikacin; Amino Acid Sequence; Animals; Base Sequence; Codon, Nonsense; Cyclic AMP; Cystic Fibrosis; | 2006 |
Modulation of gentamicin-induced renal dysfunction and injury by the phenolic extract of soybean (Glycine max).
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Disease Models, Animal; Dose-Response | 2006 |
Brain-derived neurotrophic factor treatment does not improve functional recovery after hair cell regeneration in the pigeon.
Topics: Administration, Topical; Animals; Auditory Threshold; Brain-Derived Neurotrophic Factor; Cochlea; Co | 2006 |
The effects of combined gentamicin-hydroxyapatite coating for cementless joint prostheses on the reduction of infection rates in a rabbit infection prophylaxis model.
Topics: Animals; Arthroplasty; Bone and Bones; Bone Cements; Bone Wires; Coated Materials, Biocompatible; Di | 2006 |
[Changes of angiotensin converting enzyme activity in rats with gentamicin-induced acute renal failure].
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Gentamicins; Peptidyl-Dipeptidase A; Rats | 2006 |
Curcumin attenuates gentamicin-induced renal oxidative damage in rats.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antioxidants; Curcumin; Disease Models, Animal | 2006 |
Listeria monocytogenes traffics from maternal organs to the placenta and back.
Topics: Animals; Anti-Bacterial Agents; Bacterial Translocation; Colony Count, Microbial; Disease Models, An | 2006 |
Prevention of aminoglycoside-induced sensorineural hearing loss.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Disease Models, Animal; Drug Resistance; Evoked Potent | 2006 |
A new antibacterial carrier of hyaluronic acid gel.
Topics: Animals; Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Coated Materials, Biocompatible; Dis | 2006 |
[Preparation of gentamicin-impregnated bone allograft and experimental study on treatment of infective bone defect].
Topics: Animals; Bone Substitutes; Bone Transplantation; Combined Modality Therapy; Disease Models, Animal; | 2006 |
Comparative effects of selective and non-selective nitric oxide synthase inhibition in gentamicin-induced rat nephrotoxicity.
Topics: Acetylglucosaminidase; Animals; Creatinine; Disease Models, Animal; Enzyme Inhibitors; Gentamicins; | 2007 |
[Comparative study of treatment with quinupristin-dalfopristin alone or in combination with gentamicin, teicoplanin, imipenem or levofloxacin in experimental endocarditis due to a multidrug-resistant Enterococcus faecium].
Topics: Aged; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; | 2006 |
Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; C | 2007 |
Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels.
Topics: Animals; Anti-Bacterial Agents; Colony Count, Microbial; Disease Models, Animal; Drug Delivery Syste | 2006 |
Poly(D,L-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice.
Topics: Animals; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Disease Models, Animal; Drug Carri | 2007 |
A comparative study on several models of experimental renal calcium oxalate stones formation in rats.
Topics: Ammonium Chloride; Animals; Blood Urea Nitrogen; Calcium; Calcium Gluconate; Calcium Oxalate; Creati | 2007 |
Decreased neutrophil response in a model of chronic intraperitoneal Klebsiella infection.
Topics: Animals; Anti-Bacterial Agents; Bacteremia; Disease Models, Animal; Gentamicins; Injections, Intrape | 2007 |
Schwann cells revert to non-myelinating phenotypes in the deafened rat cochlea.
Topics: Animals; Animals, Newborn; Cochlea; Deafness; Disease Models, Animal; Evoked Potentials, Auditory, B | 2007 |
A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin.
Topics: Amebicides; Aminoglycosides; Animals; Antineoplastic Agents; Codon, Nonsense; Codon, Terminator; Dis | 2007 |
Endogenous IL-10 leads to impaired bacterial clearance and reduced survival in a murine model of chronic peritonitis.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Chronic Disease; Disease Models, Animal; Gentamicins; In | 2007 |
Rapid hair cell loss: a mouse model for cochlear lesions.
Topics: Age Factors; Amikacin; Animals; Anti-Bacterial Agents; Bumetanide; Cell Death; Cell Survival; Cochle | 2008 |
Preliminary investigations on a new gentamicin and vancomycin-coated PMMA nail for the treatment of bone and intramedullary infections: An experimental study in the rabbit.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Bone Nails; Coated Materials, Biocompatible; Combined Moda | 2008 |
Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Apoptosis; Blood Pressure; Blood Urea Nitrogen; | 2008 |
Moxifloxacin versus ampicillin + gentamicin in the therapy of experimental Listeria monocytogenes meningitis.
Topics: Ampicillin; Animals; Aza Compounds; Disease Models, Animal; Drug Therapy, Combination; Fluoroquinolo | 2008 |
Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible nitric oxide synthase expression in the cochlea.
Topics: Aminoglycosides; Animals; Cochlea; Disease Models, Animal; Down-Regulation; Drug Interactions; Evoke | 2008 |
Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine.
Topics: Animals; Antigens; Apoptosis; Biomarkers; Cell Adhesion Molecules; Disease Models, Animal; Dose-Resp | 2008 |
[Clinical-experimental substantiation of preparation Kollost and bioresorbable membranes Diplen-Gum and Parodoncol use in cases of retained and dystopic mandibular third molar].
Topics: Adult; Animals; Biocompatible Materials; Collagen; Disease Models, Animal; Drug Combinations; Durapa | 2008 |
Efficacy of ceftriaxone and gentamicin in an abscess model.
Topics: Abscess; Animals; Cefotaxime; Ceftriaxone; Disease Models, Animal; Drug Evaluation, Preclinical; Dru | 1982 |
Experimental animal model of surgical wound infection applicable to antibiotic prophylaxis.
Topics: Animals; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; Clindamycin; Disease M | 1983 |
Effect of gentamicin and dexamethasone on the natural history of the rat Escherichia coli brain abscess model with histopathological correlation.
Topics: Animals; Brain Abscess; Cells, Cultured; Dexamethasone; Disease Models, Animal; Escherichia coli Inf | 1984 |
[Bolus injection, short infusion or intravenous drip of aminoglycoside antibiotics? In vivo study with netilmicin and Pseudomonas aeruginosa].
Topics: Agranulocytosis; Animals; Delayed-Action Preparations; Disease Models, Animal; Gentamicins; Infusion | 1983 |
Pharmacokinetics and bacteriological efficacy of moxalactam (LY127935), netilmicin, and ampicillin in experimental gram-negative enteric bacillary meningitis.
Topics: Ampicillin; Animals; Bacteria; Bacterial Infections; Cephalosporins; Cephamycins; Disease Models, An | 1980 |
Experimental studies on mice challenged intracerebrally with Pseudomonas aeruginosa.
Topics: Animals; Brain; Cyclophosphamide; Disease Models, Animal; Female; Gentamicins; Immunization; Immunos | 1984 |
Passive protection against Pseudomonas aeruginosa infection in an experimental leukopenic mouse model.
Topics: Animals; Antibodies, Bacterial; Antibody Specificity; Bacterial Toxins; Disease Models, Animal; Gent | 1983 |
An experimental model to assess factors associated with scleral buckle infection.
Topics: Administration, Topical; Animals; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; | 1983 |
Experimental Gram-negative bacterial sepsis: optimal methylprednisolone requirements for prevention of mortality not preventable by antibiotics alone.
Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Gentamicins; Klebsiella Infections; Kl | 1982 |
Steroid therapy in septic shock. Survival studies in a laboratory model.
Topics: Animals; Cecum; Clindamycin; Disease Models, Animal; Female; Gentamicins; Glucocorticoids; Male; Met | 1982 |
Experimental osteomyelitis caused by Pseudomonas aeruginosa.
Topics: Animals; Carbenicillin; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combinat | 1980 |
Relative efficacy of the topical use of amikacin, gentamicin and tobramycin in experimental Pseudomonas keratitis.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Guinea Pigs; Keratiti | 1980 |
Gentamicin and cefsulodin efficacy in a rat abscess model.
Topics: Abscess; Anaerobiosis; Animals; Cefsulodin; Cephalosporins; Disease Models, Animal; Female; Gentamic | 1982 |
Experimental osteomyelitis: description of a canine model and the role of depot administration of antibiotics in the prevention and treatment of sepsis.
Topics: Animals; Bone Cements; Disease Models, Animal; Dogs; Foreign Bodies; Gentamicins; Methylmethacrylate | 1983 |
Urinary myelin figures in gentamicin. Treated vs. ischemic kidneys.
Topics: Acute Kidney Injury; Animals; Constriction; Disease Models, Animal; Dogs; Gentamicins; Ischemia; Kid | 1983 |
Therapy of methicillin-resistant Staphylococcus epidermidis experimental endocarditis.
Topics: Animals; Anti-Bacterial Agents; Cephalothin; Disease Models, Animal; Drug Therapy, Combination; Endo | 1982 |
Renal handling of gentamicin by normal and ischemic canine kidneys.
Topics: Absorption; Animals; Constriction; Disease Models, Animal; Dogs; Gentamicins; Ischemia; Kidney; Kidn | 1982 |
Urinary ligandin and glutathione-S-transferase in gentamicin-induced nephrotoxicity in the rat.
Topics: Animals; Creatinine; Disease Models, Animal; Female; Gentamicins; Glutathione Transferase; Kidney Di | 1981 |
Topically administered corticosteroids: effect on antibiotic-treated bacterial keratitis.
Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Anti-Inflammatory | 1980 |
Bovine mastitis caused by Listeria monocytogenes: characteristics of natural and experimental infections.
Topics: Animals; Cattle; Cell Count; Cloxacillin; Disease Models, Animal; Drug Therapy, Combination; Ethylen | 1995 |
Development of new nephrons in adult kidneys following gentamicin-induced nephrotoxicity.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Gentamicins; Goldfish; Immunoh | 1995 |
Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection.
Topics: Animals; Disease Models, Animal; Drug Resistance, Microbial; Drug Therapy, Combination; Evaluation S | 1994 |
Failure of time-kill synergy studies using subinhibitory antimicrobial concentrations to predict in vivo antagonism of cephalosporin-rifampin combinations against Staphylococcus aureus.
Topics: Animals; Cefazolin; Cefpirome; Cephalosporins; Disease Models, Animal; Dose-Response Relationship, D | 1994 |
Pharmacokinetics of gentamicin following single dose intravenous administration in normal and febrile goats.
Topics: Analysis of Variance; Animals; Body Temperature; Computer Simulation; Disease Models, Animal; Endoto | 1994 |
Induction and intracellular localization of 90-kilodalton heat-shock protein in rat kidneys with acute gentamicin nephropathy.
Topics: Acute Kidney Injury; Animals; Cell Nucleolus; Disease Models, Animal; Electrophoresis, Polyacrylamid | 1995 |
Treatment with imipenem of experimental endocarditis caused by penicillin-resistant Streptococcus sanguis.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Endocarditis, Bacterial; Gentamicins; Im | 1994 |
Haemophilus ducreyi attaches to and invades human epithelial cells in vitro.
Topics: Animals; Bacterial Adhesion; Cells, Cultured; Chancroid; Cytochalasin B; Cytochalasin D; Disease Mod | 1994 |
Protective effects of KW-3902, a novel adenosine A1-receptor antagonist, against gentamicin-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Administration, Oral; Animals; Disease Models, Animal; Furosemide; Gentamicins; | 1994 |
Immediate pars plana vitrectomy in the management of inadvertent intracameral injection of gentamicin. A rabbit experimental model.
Topics: Animals; Anterior Chamber; Cataract Extraction; Disease Models, Animal; Gentamicins; Injections; Len | 1994 |
Investigation of the potential role of Enterococcus faecalis in the pathophysiology of experimental peritonitis.
Topics: Abscess; Amoxicillin; Animals; Anti-Bacterial Agents; Bacteremia; Bacteroides fragilis; Bacteroides | 1994 |
Intravesical instillation of gentamicin sulfate: in vitro, rat, canine, and human studies.
Topics: Absorption; Administration, Intravesical; Adolescent; Animals; Bacteria; Child; Child, Preschool; Di | 1994 |
Activity of isepamicin and selection of permeability mutants to beta-lactams during aminoglycoside therapy of experimental endocarditis due to Klebsiella pneumoniae CF104 producing an aminoglycoside acetyltransferase 6' modifying enzyme and a TEM-3 beta-l
Topics: Acetyltransferases; Amikacin; Animals; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; bet | 1994 |
Continuous flow perfusion of gentamicin with a scleral shell reduces bacterial colony counts in experimental Pseudomonas keratitis.
Topics: Animals; Colony Count, Microbial; Disease Models, Animal; Eye Infections, Bacterial; Gentamicins; Ke | 1993 |
Retrospective study comparing the pathophysiology of antibiotic-treated and untreated Escherichia coli- and Staphylococcus aureus-infused baboons.
Topics: Animals; Ceftriaxone; Disease Models, Animal; Escherichia coli Infections; Gentamicins; Hemodynamics | 1993 |
NPC 15669 reduces mortality associated with sepsis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Feces; Gentamicins; Leucin | 1993 |
Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.
Topics: Ampicillin Resistance; Animals; Ciprofloxacin; Disease Models, Animal; Drug Resistance, Microbial; D | 1993 |
Quantitative studies of invasion of rabbit ileal mucosa by Salmonella typhimurium strains which differ in virulence in a model of gastroenteritis.
Topics: Animals; Culture Media; Disease Models, Animal; Gastroenteritis; Gentamicins; Ileum; Intestinal Muco | 1994 |
Triple combination penicillin-vancomycin-gentamicin for experimental endocarditis caused by a highly penicillin-and glycopeptide-resistant isolate of Enterococcus faecium.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Resistance, Microbial; Drug Synergism; | 1993 |
Comparison of ampicillin-sulbactam with vancomycin for treatment of experimental endocarditis due to a beta-lactamase-producing, highly gentamicin-resistant isolate of Enterococcus faecalis.
Topics: Ampicillin; Animals; Aortic Valve; beta-Lactamases; Disease Models, Animal; Drug Resistance, Microbi | 1993 |
Treatment of experimental osteomyelitis with antibiotic-impregnated bone graft substitute.
Topics: Animals; Bone Transplantation; Chronic Disease; Colony Count, Microbial; Combined Modality Therapy; | 1993 |
Urine profiles and kidney histologic findings after intravenous injection of mannitol and iohexol in the degeneration phase of gentamicin nephropathy in rats.
Topics: Animals; Blood Chemical Analysis; Disease Models, Animal; Gentamicins; Injections, Intravenous; Iohe | 1993 |
Bioerodible polyanhydrides for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system.
Topics: Animals; Biocompatible Materials; Colony Count, Microbial; Decanoic Acids; Dicarboxylic Acids; Disea | 1993 |
Altered localization of 73-kilodalton heat-shock protein in rat kidneys with gentamicin-induced acute tubular injury.
Topics: Animals; Disease Models, Animal; Gentamicins; Heat-Shock Proteins; Kidney Tubular Necrosis, Acute; L | 1993 |
Efficacy of topical gentamicin treatment after 193-nm photorefractive keratectomy in an experimental Pseudomonas keratitis model.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Cornea; Debridemen | 1995 |
Glutathione protection against gentamicin ototoxicity depends on nutritional status.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Ascorbic Acid; Cochlea; Diet; Dietary Proteins | 1995 |
Impact of different classes antimicrobial agents on plasma endotoxin activity.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Blood Pressure; Cefotaxime; Cepha | 1996 |
An animal model of pulmonary infection after single lung transplantation.
Topics: Analysis of Variance; Animals; Cefazolin; Clindamycin; Disease Models, Animal; Dogs; Drug Therapy, C | 1996 |
A sensitive animal model to assess acute and chronic ototoxic effects.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Auditory Threshold; Diet, Protein-Restricted; Disease | 1996 |
Glomerular angiotensin II receptors in gentamicin-induced renal failure in the rat.
Topics: Acute Kidney Injury; Analysis of Variance; Angiotensin II; Animals; Anti-Bacterial Agents; Creatinin | 1995 |
Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye.
Topics: Absorption; Administration, Topical; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Aqueous | 1996 |
Inhibition of proteases in Pseudomonas otitis media in chinchillas.
Topics: Animals; Anti-Bacterial Agents; Chinchilla; Dipeptides; Disease Models, Animal; Gentamicins; Otitis | 1996 |
Model of Streptococcus pneumoniae meningitis in adult rats.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Brain; Cefotaxime; Cerebrospinal Fluid; Disease Models, | 1996 |
New murine model of bronchopneumonia due to cell-bound Haemophilus influenzae.
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Blood Bactericidal Activity; Bronchi; Bronchopne | 1997 |
A comparison of bactericidal/permeability-increasing protein variant versus recombinant endotoxin-neutralizing protein for the treatment of Escherichia coli sepsis in rats .
Topics: Animals; Anti-Infective Agents; Ceftriaxone; Disease Models, Animal; Drug Therapy, Combination; Esch | 1997 |
Intraotic administration of gentamicin: a new method to study ototoxicity in the crista ampullaris of the bullfrog.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relat | 1997 |
PMMA bead versus parenteral treatment of Staphylococcus aureus osteomyelitis.
Topics: Animals; Anti-Bacterial Agents; Clindamycin; Disease Models, Animal; Drug Delivery Systems; Gentamic | 1997 |
Pulmonary administration of gentamicin during liquid ventilation in a newborn lamb lung injury model.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Disease Models, Animal; Fluorocarbons; Gentamicins | 1997 |
Topical use of zinc desferrioxamine for corneal alkali injury in a rabbit model.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Burns, Chemical; Cornea; Corneal Injuries; | 1998 |
Granulocyte colony-stimulating factor and antibiotics in the prophylaxis of a murine model of polymicrobial peritonitis and sepsis.
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cecum; Clindamycin; Colony Count, Microbial; | 1998 |
Comparison between plain and gentamicin containing collagen sponges in infected peritoneal cavity in rats.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Chi-Square Distribution; Collagen; Disease Mod | 1998 |
[Tricalcium phosphate, an antibiotic carrier: a study focused on experimental osteomyelitis in rabbits].
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Bone Substitutes; Calcium Phosphates; Ceram | 1998 |
Efficacy of gentamycin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Biodegradation, Environmental; Bone Cements; | 1999 |
Morphologic changes in the inner ear of Chinchilla laniger after middle ear administration of gentamicin in a sustained-release vehicle.
Topics: Animals; Anti-Bacterial Agents; Chinchilla; Delayed-Action Preparations; Disease Models, Animal; Dru | 1999 |
Middle ear instillation of gentamicin and streptomycin in chinchillas: morphologic appraisal of selective ototoxicity.
Topics: Animals; Anti-Bacterial Agents; Chinchilla; Cochlea; Disease Models, Animal; Drug Administration Rou | 1999 |
Influence of adjunctive interferon-gamma on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice.
Topics: Animals; Disease Models, Animal; Drug Resistance, Microbial; Drug Therapy, Combination; Enterococcus | 1999 |
Apatite cement containing antibiotics: efficacy in treating experimental osteomyelitis.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Apatites; Bone Cements; Bone Marrow; Bone T | 1999 |
Development of a long-term ascending urinary tract infection mouse model for antibiotic treatment studies.
Topics: Animals; Anti-Bacterial Agents; Cefuroxime; Disease Models, Animal; Dose-Response Relationship, Drug | 2000 |
Effect of violation of the labyrinth on the sensory epithelium in the chick cochlea.
Topics: Animals; Bromodeoxyuridine; Catheterization; Cell Death; Chickens; Cochlea; Disease Models, Animal; | 2000 |
Assessment of vestibular ototoxicity of ear drops by recording of vestibular evoked potentials to acceleration impulses.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cochlear Diseases; Disease Models, Animal; | 2000 |
Antibiotic levels in empyemic pleural fluid.
Topics: Animals; Anti-Bacterial Agents; Biological Availability; Ceftriaxone; Clindamycin; Disease Models, A | 2000 |
Bactericidal activity of gentamicin against Enterococcus faecalis in vitro and in vivo.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Endocarditis, Bacterial; Enterococcus faecal | 2000 |
Efficacy of ampicillin plus arbekacin in experimental rabbit endocarditis caused by an Enterococcus faecalis strain with high-level gentamicin resistance.
Topics: Aminoglycosides; Ampicillin; Animals; Anti-Bacterial Agents; Dibekacin; Disease Models, Animal; Drug | 2000 |
Activity of LY333328 combined with gentamicin in vitro and in rabbit experimental endocarditis due to vancomycin-susceptible or -resistant Enterococcus faecalis.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Therapy, Combination; Endocarditis, Bac | 2000 |
Gastrointestinal colonization by Candida albicans mutant strains in antibiotic-treated mice.
Topics: Animals; Anti-Bacterial Agents; Bacitracin; Candida albicans; Candidiasis; Digestive System; Disease | 2001 |
Effect of gentamicin-containing sponges on the healing of colonic anastomoses in a rat model of peritonitis.
Topics: Anastomosis, Surgical; Animals; Anti-Bacterial Agents; Collagen; Disease Models, Animal; Drug Delive | 2000 |
Ginkgo biloba extract ameliorates gentamicin-induced nephrotoxicity in rats.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antioxidants; Disease Models, Animal; Gentamic | 2000 |
[Methodology for designing pathological models of acute renal failure].
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Dogs; Female; Gentamicins; Glycerol; Kidney; M | 1998 |
Efficacy of teicoplanin-gentamicin given once a day on the basis of pharmacokinetics in humans for treatment of enterococcal experimental endocarditis.
Topics: Animals; Disease Models, Animal; Drug Combinations; Endocarditis, Bacterial; Enterococcus faecalis; | 2001 |
Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach.
Topics: Albumins; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Blood Proteins; Creatinine; Disease M | 2001 |
Plasma erythropoietin level in rats after kidney proximal tubular impairment.
Topics: Anemia; Animals; Disease Models, Animal; Erythropoiesis; Erythropoietin; Gentamicins; Hematologic Te | 2000 |
Intratracheal administration of perfluorochemical-gentamicin suspension: a comparison to intravenous administration in normal and injured lungs.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Disease Models, Animal; Fluorocarbons; Gentamicins | 2001 |
Consequences of VanE-type resistance on efficacy of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecalis.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Thera | 2001 |
Gentamicin concentrations in urine, cortex and medulla in an acutely obstructed kidney animal model.
Topics: Acute Disease; Animals; Disease Models, Animal; Gentamicins; Guinea Pigs; Kidney Cortex; Kidney Medu | 2001 |
Variations in the csgD promoter of Escherichia coli O157:H7 associated with increased virulence in mice and increased invasion of HEp-2 cells.
Topics: Animals; Chlorocebus aethiops; Coloring Agents; Congo Red; Disease Models, Animal; Electrophoresis, | 2002 |
Gentamicin increases the efficacy of vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; G | 2002 |
Efficacy of ceftriaxone and gentamicin given once a day by using human-like pharmacokinetics in treatment of experimental staphylococcal endocarditis.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cephalosporins; Disease Models, Animal; Drug Therapy, C | 2002 |
[Experimental and clinical study of gentamicin-loaded chitosan drug delivery system].
Topics: Animals; Anti-Bacterial Agents; Chitin; Chitosan; Delayed-Action Preparations; Disease Models, Anima | 2000 |
Antinociceptive potency of aminoglycoside antibiotics and magnesium chloride: a comparative study on models of phasic and incisional pain in rats.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug | 2002 |
Release of netilmicin and vancomycin from cancellous bone.
Topics: Animals; Anti-Bacterial Agents; Bony Callus; Disease Models, Animal; Femur; Gentamicins; Humans; Hyd | 2002 |
Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa.
Topics: Animals; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Translocation; Carrier Pro | 2002 |
Factors influencing the therapy of experimental Proteus mirabilis meningitis in rabbits.
Topics: Animals; Chloramphenicol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; | 1978 |
Antibiotic treatment of guinea-pigs infected with agent of Legionnaires' disease.
Topics: Administration, Oral; Animals; Chloramphenicol; Disease Models, Animal; Drug Evaluation; Drug Evalua | 1978 |
Experimental and clinical experience with hyperbaric oxygen in the treatment of clostridial myonecrosis.
Topics: Adult; Amputation, Surgical; Antitoxins; Bacteroides Infections; Cephalothin; Clindamycin; Clostridi | 1975 |
Antibiotic therapy of experimental Pseudomonas keratitis in guinea pigs.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Aqueous Humor; Carbenicillin; Cornea; Disea | 1977 |
Endotoxin and the liver. III. Modification of acute carbon tetrachloride injury by polymyxin b--an antiendotoxin.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Female; Genta | 1978 |
[Addition of gentamicine to polymethyl methacrylate for therapy of infectious bone diseases. Expeimental in vivo tests].
Topics: Animals; Arthroplasty; Bone and Bones; Bone Cements; Disease Models, Animal; Drug Resistance, Microb | 1975 |
Penetration of gentamicin into the aphakic eye.
Topics: Administration, Topical; Animals; Aqueous Humor; Biopharmaceutics; Cataract Extraction; Conjunctiva; | 1977 |
Therapy for experimental intraabdominal sepsis: comparison of four cephalosporins with clindamycin plus gentamicin.
Topics: Abdomen; Abscess; Animals; Bacteroides fragilis; Cephalosporins; Clindamycin; Disease Models, Animal | 1977 |
Experimental pyelonephritis induced by L-forms of Proteus mirabilis in rats.
Topics: Animals; Disease Models, Animal; Female; Gentamicins; L Forms; Proteus mirabilis; Pyelonephritis; Ra | 1978 |
Synergism of ampicillin and gentamicin against obstructive pyelonephritis due to Escherichia coli in rats.
Topics: Acute Disease; Ampicillin; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combinatio | 1979 |
Prevention of pyelonephritis due to Escherichia coli in rats with gentamicin stored in kidney tissue.
Topics: Ampicillin; Animals; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Gentamic | 1979 |
Experimental pneumonia due to Pseudomonas aeruginosa in leukopenic dogs: prolongation of survival by combined treatment with passive antibody to Pseudomonas and granulocyte transfusions.
Topics: Animals; Antibodies, Bacterial; Blood Transfusion; Disease Models, Animal; Dogs; Gentamicins; Granul | 1977 |
Virulent gentamicin-induced small colony variants of Staphylococcus aureus.
Topics: Animals; Disease Models, Animal; Endocarditis, Bacterial; Genetic Variation; Gentamicins; Mutation; | 1979 |
The influence of dosage regimen on experimental gentamicin nephrotoxicity: dissociation of peak serum levels from renal failure.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drug Administ | 1979 |
Comparative nephrotoxicity of gentamicin and tobramycin in rats.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Kidney; Kidney Tubular Necrosis | 1978 |
Bacterial renal infection in rats produced by direct injection of bacteria into renal tissue--an experimental model.
Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Female; Gentamicins; Kidney; Kidney Di | 1975 |
Proteus species isolated from human eyes.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Eye Diseases; Gentamicins; Humans; Keratitis | 1976 |
An experimental model of Pseudomonas aeruginosa renal infection in rats.
Topics: Bacteriuria; Body Weight; Carbenicillin; Disease Models, Animal; Drug Evaluation; Drug Therapy, Comb | 1975 |
Effect of drugs on infant Gunn rats under phototherapy.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Benzyl Alcohols; Bilirubin; Body Weight; Cerebellu | 1976 |
Comparative penetration of amikacin, gentamicin, and penicillin g into exudate fluid in experimental sterile peritonitis.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Ascitic Fluid; Disease Models, Animal; Gentamicins; Inject | 1977 |
Clindamycin-associated colitis in hamsters: protection with vancomycin.
Topics: Animals; Clindamycin; Colon; Cricetinae; Disease Models, Animal; Enterocolitis, Pseudomembranous; Ge | 1977 |
Topical antibiotic therapy of staphylococcal keratitis.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Chlortetracycline; Disease Models, Animal; | 1977 |
[Ototoxic effects of some aminoglycoside antibiotics on the inner ear in the spontaneously hypertensive rats (SHR) (author's transl)].
Topics: Animals; Anti-Bacterial Agents; Body Weight; Dibekacin; Disease Models, Animal; Ear, Inner; Gentamic | 1977 |
Bacterial infection and acrylic cement in the rat.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Bone Cements; Bone Diseases; Disease Models, A | 1977 |
Renal glycosuria due to gentamicin in rabbits.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Gentamicins; Glomerular Filtration Rate; Glyco | 1976 |
Subconjunctival gentamicin prophylaxis against postoperative endophthalmitis in the rabbit.
Topics: Animals; Aqueous Humor; Cataract Extraction; Conjunctiva; Disease Models, Animal; Eye Diseases; Fema | 1976 |
Vitrectomy in endophthalmitis. Results of study using vitrectomy, intraocular antibiotics, or a combination of both.
Topics: Animals; Disease Models, Animal; Endophthalmitis; Gentamicins; Rabbits; Staphylococcal Infections; V | 1976 |
Suppression of Candida albicans by Escherichia coli.
Topics: Animals; Burns; Candida albicans; Candidiasis; Cells, Cultured; Dialysis; Disease Models, Animal; Es | 1975 |
Antimicrobial therapy of experimental endocarditis caused by Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Cephalothin; Clindamycin; Disease Models, Animal; Drug Therapy, Comb | 1975 |
Antimicrobial therapy of experimental intraabdominal sepsis.
Topics: Abscess; Animals; Clindamycin; Disease Models, Animal; Drug Therapy, Combination; Gentamicins; Perit | 1975 |
Experimental osteomyelitis. IV. Therapeutic trials with rifampin alone and in combination with gentamicin, sisomicin, and cephalothin.
Topics: Animals; Anti-Bacterial Agents; Cephalothin; Disease Models, Animal; Drug Evaluation, Preclinical; D | 1975 |
Treatment of intra-abdominal infection with granulocyte colony-stimulating factor.
Topics: Animals; Cecum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinic | 1992 |
[The effect of recombinant interleukin-2 on the course of experimental staphylococcal peritonitis in mice].
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Gentamicins; Interleukin-2; M | 1992 |
Efficacy of L-627, a new carbapenem, in the treatment of experimentally induced intra-abdominal infections in rats.
Topics: Abdomen; Animals; Bacterial Infections; Carbapenems; Disease Models, Animal; Gentamicins; Intestines | 1992 |
Contribution of animal models in the search for effective therapy for endocarditis due to enterococci with high-level resistance to gentamicin.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Daptomycin; Disease Models, Animal; Drug Resistance, Mic | 1992 |
Experimental gastrointestinal and disseminated candidiasis in immunocompromised animals.
Topics: Animals; Candida albicans; Candidiasis; Cytarabine; Disease Models, Animal; Female; Gastrointestinal | 1992 |
[Antibiotic therapy in acute diffuse peritonitis].
Topics: Acute Disease; Animals; Disease Models, Animal; Dogs; Gentamicins; Injections, Intramuscular; Inject | 1992 |
[Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague].
Topics: Amikacin; Animals; Culture Media; Disease Models, Animal; Drug Evaluation, Preclinical; Gentamicins; | 1992 |
Efficacy of tosufloxacin in the treatment of experimentally induced intra-abdominal infections in rats.
Topics: 4-Quinolones; Abscess; Animals; Anti-Infective Agents; Bacterial Infections; Disease Models, Animal; | 1992 |
Systemic antibiotic prophylaxis in penetrating ocular injuries. An experimental study.
Topics: Animals; Anterior Chamber; Cefazolin; Disease Models, Animal; Drug Administration Schedule; Endophth | 1992 |
[Search for inhibitors of West Nile virus among antibiotics].
Topics: Animals; Antiviral Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Gentamicins; Kanamy | 1992 |
[Alterations in phosphatidylcholine and phospholipase A2 of the renal tissue in gentamicin nephrotoxicity: comparative study with buthionine sulfoximine administered model].
Topics: Acute Kidney Injury; Animals; Buthionine Sulfoximine; Disease Models, Animal; Gentamicins; Glutathio | 1992 |
In vivo postantibiotic effect of isepamicin and other aminoglycosides in a thigh infection model in neutropenic mice.
Topics: Animals; Bacterial Infections; Disease Models, Animal; Escherichia coli; Female; Gentamicins; Mice; | 1992 |
Evaluation of corneal collagen shields as a drug delivery device for the treatment of experimental Pseudomonas keratitis.
Topics: Animals; Biological Dressings; Collagen; Colony Count, Microbial; Cornea; Disease Models, Animal; Dr | 1992 |
Tinnitus-induced weight loss in rats. An animal model for tinnitus research.
Topics: Animals; Disease Models, Animal; Female; Gentamicins; Growth Disorders; Noise; Pilot Projects; Quini | 1991 |
[Experimental substantiation of using gentacycol for prevention of wound infection in gunshot bone fractures of the extremities].
Topics: Animals; Arm Injuries; Bacterial Infections; Disease Models, Animal; Dogs; Drug Evaluation, Preclini | 1991 |
Impact of the duration of infection on the activity of ceftazidime, gentamicin and ciprofloxacin in Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats.
Topics: Animals; Bacteremia; Ceftazidime; Ciprofloxacin; Disease Models, Animal; Drug Administration Schedul | 1991 |
Coryneform group A-4 endophthalmitis. An experimental animal model.
Topics: Animals; Corynebacterium Infections; Disease Models, Animal; Endophthalmitis; Eye Infections, Bacter | 1991 |
Resistance of Staphylococcus aureus recovered from infected foreign body in vivo to killing by antimicrobials.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Diffusion Chambers, Culture; D | 1991 |
A new model of nephrolithiasis involving tubular dysfunction/injury.
Topics: Animals; Calcium Oxalate; Disease Models, Animal; Gentamicins; Kidney; Kidney Calculi; Kidney Tubule | 1991 |
Anatomical correlates of functional recovery in the avian inner ear following aminoglycoside ototoxicity.
Topics: Animals; Cell Count; Chickens; Cochlea; Disease Models, Animal; Evoked Potentials, Auditory; Gentami | 1991 |
Effect of intravitreal dexamethasone on ocular histopathology in a rabbit model of endophthalmitis.
Topics: Animals; Dexamethasone; Disease Models, Animal; Endophthalmitis; Eye; Gentamicins; Rabbits; Random A | 1991 |
[Distribution of gentamicin in the eye after administration of eye film by various methods].
Topics: Animals; Aqueous Humor; Conjunctiva; Conjunctivitis; Disease Models, Animal; Drug Implants; Eye Infe | 1991 |
Prevention of Escherichia coli K1 bacteremia in newborn mice by using topical vaginal carbohydrates.
Topics: Administration, Intravaginal; Animals; Animals, Newborn; Disease Models, Animal; Drug Therapy, Combi | 1990 |
Gentamicin iontophoresis in the treatment of bacterial otitis externa in the guinea pig model.
Topics: Animals; Disease Models, Animal; Edema; Gentamicins; Guinea Pigs; Iontophoresis; Otitis Externa; Pse | 1990 |
Treatment of disseminated Mycobacterium avium complex infection of beige mice with liposome-encapsulated aminoglycosides.
Topics: Amikacin; Animals; Disease Models, Animal; Drug Carriers; Female; Follow-Up Studies; Gentamicins; Li | 1990 |
Synergism between cefotaxime and fosfomycin in the therapy of methicillin and gentamicin resistant Staphylococcus aureus infection in rabbits.
Topics: Analysis of Variance; Animals; Cefotaxime; Disease Models, Animal; Drug Administration Schedule; Dru | 1990 |
Liposome-encapsulated-gentamicin therapy of Mycobacterium avium complex infection in beige mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Dru | 1990 |
Effects of clindamycin and gentamicin and other antimicrobial combinations against enterococci in an experimental model of intra-abdominal abscess.
Topics: Abdominal Muscles; Abscess; Ampicillin; Animals; Clindamycin; Disease Models, Animal; Drug Evaluatio | 1989 |
Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection models.
Topics: Animals; Anti-Bacterial Agents; Cefazolin; Ceftazidime; Disease Models, Animal; Dose-Response Relati | 1989 |
LY146032, alone and in combination with gentamicin, for the treatment of enterococcal pyelonephritis in the rat model.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Daptomycin; Disease Models, Animal; Drug Therapy, Combin | 1988 |
The efficacy of pefloxacin in comparison to gentamicin in the treatment of experimentally induced peritonitis in rats.
Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Bacteroides fragilis; Clo | 1986 |
Pathogenicity of capsulate and non-capsulate members of Bacteroides fragilis and B. melaninogenicus groups in mixed infection with Escherichia coli and Streptococcus pyogenes.
Topics: Abscess; Aerobiosis; Anaerobiosis; Animals; Bacteroides; Bacteroides fragilis; Bacteroides Infection | 1988 |
Development of neomycin-resistant WEHI-3B D+ murine cells as an in vivo model of acute nonlymphocytic leukemia.
Topics: Animals; Blotting, Southern; Cell Differentiation; Cell Line; Clone Cells; Disease Models, Animal; D | 1989 |
The effect of tuftsin in the treatment of experimental Pseudomonas keratitis.
Topics: Animals; Colony Count, Microbial; Disease Models, Animal; Drug Combinations; Eye Infections, Bacteri | 1986 |
Spontaneous inhibition of bacterial growth in experimental gram-negative endophthalmitis.
Topics: Animals; Cefoperazone; Disease Models, Animal; Endophthalmitis; Gentamicins; Hydrogen-Ion Concentrat | 1987 |
In vivo and in vitro activity of ciprofloxacin plus azlocillin against 12 streptococcal isolates in a neutropenic site model.
Topics: Amikacin; Animals; Azlocillin; Ciprofloxacin; Disease Models, Animal; Drug Synergism; Drug Therapy, | 1987 |
Pharmacokinetics and therapeutic efficacy of gentamicin in an experimental pleural empyema rabbit model.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Carbon Dioxide; Combined Modality Therapy; Disease Model | 1987 |
Absence of a postantibiotic effect in experimental Pseudomonas endocarditis treated with imipenem, with or without gentamicin.
Topics: Animals; Aortic Valve; Disease Models, Animal; Drug Therapy, Combination; Endocarditis, Bacterial; G | 1988 |
Comparative efficacy of ciprofloxacin, ceftazidime and gentamicin, given alone or in combination, in a model of experimental septicemia due to Klebsiella pneumoniae in neutropenic mice.
Topics: Agranulocytosis; Animals; Ceftazidime; Ciprofloxacin; Disease Models, Animal; Drug Therapy, Combinat | 1988 |
Increased plasma levels of endotoxin and corresponding changes in circulatory performance in a porcine sepsis model: the effect of antibiotic administration.
Topics: Animals; Cardiac Output; Disease Models, Animal; Endotoxins; Gentamicins; Hemodynamics; Sepsis; Swin | 1988 |
N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and an animal model.
Topics: Adolescent; Adult; Aniline Compounds; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; El | 1986 |
Efficacies of trimethoprim-sulfadiazine and gentamicin sulfate in the treatment of fibrinous peritonitis in rats.
Topics: Animals; Disease Models, Animal; Drug Combinations; Gentamicins; Male; Peritonitis; Rats; Rats, Inbr | 1987 |
Gentamicin-induced loss of basolateral surface area of rat proximal convoluted tubules.
Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Gentamicins; Kidney Tubules, Proxi | 1987 |
Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Ge | 1985 |
A rat model of bacterial keratitis. Effect of antibiotics and corticosteroid.
Topics: Animals; Bacterial Infections; Cephalosporins; Cephradine; Disease Models, Animal; Drug Therapy, Com | 1985 |
2,3-Dihydroxybenzoic acid. Effect on mortality rate in a septic rat model.
Topics: Abdomen; Animals; Bacterial Infections; Dimethyl Sulfoxide; Disease Models, Animal; Drug Therapy, Co | 1985 |
[Studies on the hamster colitis model].
Topics: Animals; Cricetinae; Disease Models, Animal; Enterocolitis, Pseudomembranous; Female; Gentamicins; M | 1985 |
Infections caused by Pseudomonas species in patients with burns and in other surgical patients.
Topics: Administration, Topical; Animals; Burns; Colistin; Cross Infection; Disease Models, Animal; Drug Res | 1974 |
[Models of urinary infection].
Topics: Animals; Bacterial Infections; Bacteriuria; Carbenicillin; Disease Models, Animal; Drug Therapy, Com | 1974 |
The effect of tobramycin on Pseudomonas keratitis.
Topics: Amino Sugars; Animals; Anti-Bacterial Agents; Cornea; Disease Models, Animal; Edetic Acid; El Salvad | 1973 |
Granulocyte transfusion therapy of experimental Pseudomonas pneumonia.
Topics: Animals; Blood Platelets; Blood Transfusion; Disease Models, Animal; Dogs; Gentamicins; Leukocyte Co | 1974 |
Experimental pneumonia due to Pseudomonas in dogs: controlled trial of granulocyte transfusion therapy.
Topics: Agranulocytosis; Animals; Blood Transfusion; Disease Models, Animal; Dogs; Gentamicins; Granulocytes | 1974 |
Experimental pseudomonas osteomyelitis: treatment with sisomicin and carbenicillin.
Topics: Aminoglycosides; Animals; Autopsy; Carbenicillin; Disease Models, Animal; Drug Therapy, Combination; | 1974 |
Antimicrobial therapy in experimental pseudomonas infection.
Topics: Animals; Carbenicillin; Colistin; Disease Models, Animal; Drug Therapy, Combination; Gentamicins; Ma | 1974 |
[Gentamycin treatment in experimental Coli-infection after immunosuppression].
Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Gentamicins; Immunosuppression Therapy | 1971 |
Colistin and genticyn in the treatment of Pseudomonas corneal ulcer.
Topics: Animals; Colistin; Corneal Ulcer; Disease Models, Animal; Drug Combinations; Gentamicins; Ophthalmic | 1974 |
Experiments on ototoxic effects of antibiotics.
Topics: Animals; Cochlea; Cytoplasm; Disease Models, Animal; Ear, Middle; Gentamicins; Guinea Pigs; Histolog | 1973 |
Gentamicin penetration in the aqueous humor of eyes with corneal ulcers.
Topics: Absorption; Animals; Aqueous Humor; Bacteriological Techniques; Conjunctiva; Corneal Ulcer; Disease | 1972 |
[Experimental model of infection].
Topics: Animals; Anti-Bacterial Agents; Carbenicillin; Carboxylic Acids; Disease Models, Animal; Drug Synerg | 1973 |
Therapy of experimental staphylococcal infection with antibiotic combinations.
Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Disease Models, Animal; Drug Antagonism; Drug Syner | 1974 |
Rat pyelonephritis model suitable for primary or secondary screening.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Disease Models, Animal; Escherich | 1969 |
[Experimental cystitis in rats and its chemotherapy].
Topics: Animals; Bacteriuria; Cystitis; Disease Models, Animal; Escherichia coli; Escherichia coli Infection | 1970 |
Depression and stimulation of host defense mechanisms after severe burns.
Topics: Animals; Burns; Chloramphenicol; Disease Models, Animal; Gentamicins; Mice; Mononuclear Phagocyte Sy | 1970 |
[In vitro and in vivo tuberculostatic effects of gentamicin on Mycobacterium tuberculosis].
Topics: Animals; Disease Models, Animal; Gentamicins; Mice; Mycobacterium tuberculosis; Tuberculosis, Pulmon | 1970 |
[Effect of various antibiotics and the new gentamicin preparation against various pathogenic microbes].
Topics: Animals; Anti-Bacterial Agents; Cricetinae; Disease Models, Animal; Drug Resistance, Microbial; Ente | 1968 |
Possible nephrotoxicity of gentamicin.
Topics: Acute Kidney Injury; Adult; Age Factors; Aminohippuric Acids; Animals; Creatinine; Dehydration; Dise | 1971 |
Synergy of carbenicillin and gentamicin in experimental infection with Pseudomonas.
Topics: Animals; Carbenicillin; Disease Models, Animal; Drug Synergism; Gentamicins; Penicillins; Pseudomona | 1971 |
[Carbenicillin and gentamicin in experimental Pseudomonas cystitis].
Topics: Animals; Body Weight; Cystitis; Disease Models, Animal; Female; Gentamicins; Penicillins; Pseudomona | 1969 |
[Effect of gentamicin on model staphylococcal septicemia].
Topics: Animals; Disease Models, Animal; Gentamicins; Mice; Sepsis; Staphylococcal Infections | 1970 |
[Comparison of the effects of gentamicin and other chemotherapeutic agents in experimental urinary tract infections].
Topics: Animals; Anti-Infective Agents; Cephalosporins; Colistin; Cystitis; Disease Models, Animal; Gentamic | 1970 |
Experimental infection of the skin in the hamster simulating human impetigo. II. Assessment of various therapeutic regimens.
Topics: Animals; Anti-Infective Agents, Local; Bacitracin; Cricetinae; Debridement; Disease Models, Animal; | 1971 |