Page last updated: 2024-10-27

gentamicin and Diathesis

gentamicin has been researched along with Diathesis in 20 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

ExcerptRelevanceReference
" Similarly, resistance to ampicillin and gentamicin, the empirically used antibiotics for patients with fever of unknown origin, was found in E."3.69Stool cultures obtained before liver transplantation are useful for choice of perioperative antibiotic prophylaxis. ( Andersson, J; Barkholt, LM; Bergquist, A; Broomé, U; Duraj, F; Ericzon, BG; Herlenius, G; Nord, CE; Palmgren, AC, 1997)
" To this end, rats were treated with a subtoxic dosage of the experimental nephrotoxin uranyl nitrate (UN) in the drinking water for 21 weeks, or plain water (as control), and then with low-dose gentamicin for 7 days."1.39Increased urinary excretion of albumin, hemopexin, transferrin and VDBP correlates with chronic sensitization to gentamicin nephrotoxicity in rats. ( Ferreira, L; González-Buitrago, JM; López-Hernández, FJ; López-Novoa, JM; Morales, AI; Vicente-Vicente, L, 2013)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's6 (30.00)18.2507
2000's3 (15.00)29.6817
2010's10 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Franko, B1
Vaillant, M1
Recule, C1
Vautrin, E1
Brion, JP1
Pavese, P1
Chebbi, W1
Berriche, O1
Brand, Y1
Levano, S1
Radojevic, V1
Naldi, AM1
Setz, C1
Ryan, AF1
Pak, K1
Hemmings, BA1
Bodmer, D1
Bonavila Juan, C1
Michelena Bengoechea, A1
Zubeltzu Sese, B1
Goenaga Sánchez, MÁ1
Tinoco, I1
López, E1
Gutiérrez, JF1
Gamaza, S1
Espandiari, P1
Rosenzweig, B1
Zhang, J1
Zhou, Y1
Schnackenberg, L1
Vaidya, VS1
Goering, PL1
Brown, RP1
Bonventre, JV1
Mahjoob, K1
Holland, RD1
Beger, RD1
Thompson, K1
Hanig, J1
Sadrieh, N1
Suel, P1
Martin, P1
Berthelot, G1
Robaday, S1
Etienne, M1
Chibani, A1
Palacián Ruiz, MP1
Cameo Rico, MI1
Arazo Garcés, P1
Marco Lamata, ML1
Revillo Pinilla, MJ1
Giuliano, S1
Caccese, R1
Carfagna, P1
Vena, A1
Falcone, M1
Venditti, M1
Vicente-Vicente, L1
Ferreira, L1
González-Buitrago, JM1
López-Hernández, FJ1
López-Novoa, JM1
Morales, AI1
Flores, C1
Maguilnik, I1
Hadlich, E1
Goldani, LZ1
Friberg, O1
Svedjeholm, R1
Söderquist, B1
Granfeldt, H1
Vikerfors, T1
Källman, J1
Oteo, JA1
Castilla, A1
Arosey, A1
Blanco, JR1
Ibarra, V1
Morano, LE1
Zager, RA1
Sharma, HM1
Islam, MR1
Alam, AN1
Hussain, MS1
Mahalanabis, D1
Roiz, MP1
del Palacio, A1
Alonso, MA1
Pérez, E1
Robbins, J1
Barkholt, LM1
Andersson, J1
Ericzon, BG1
Palmgren, AC1
Broomé, U1
Duraj, F1
Bergquist, A1
Herlenius, G1
Nord, CE1
Wu, J1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery[NCT03574090]Phase 4268 participants (Actual)Interventional2020-10-20Completed
Local Application of Collagen-Gentamicin in Addition to Fixation of the Sternum With Extra Sternal Wires for Prevention of Sternal Wound Infection in Cardiac Surgery[NCT00484055]1,358 participants (Actual)Interventional2007-01-31Completed
Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery[NCT04238923]Phase 2/Phase 3356 participants (Anticipated)Interventional2020-05-01Not yet recruiting
A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications.[NCT00638014]Phase 451 participants (Actual)Interventional2008-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Sternal Wound Infection or Sternal Instability/Non-union

The Data and Safety Monitoring Board reviewed source documents for all cases with possible sternal wound infection and sternal instability or non-union and made a determination as to the presence of these complications. (NCT00638014)
Timeframe: Up to 180 days

InterventionParticipants (Number)
Conventional Wires Only1
Talon1

Percentage Change of Preoperative Incentive Spirometry (IS) Volume Achieved

Maximum incentive spirometry volume was measured at baseline (prior to surgery) and daily from postoperative day 1 through postoperative day 7 (or discharge if earlier) using a Coach 2 incentive spirometer with one way valve (Coach 2 model # 22-4000, Smiths Medical, Keene, NH). (NCT00638014)
Timeframe: Baseline, Maximum value during postoperatively days 1 thru 7

Interventionpercentage change (Mean)
Conventional Wires Only58
Talon67

Reviews

5 reviews available for gentamicin and Diathesis

ArticleYear
Lactobacillus paracasei endocarditis in a consumer of probiotics.
    Medecine et maladies infectieuses, 2013, Volume: 43, Issue:4

    Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Antimanic Agents; Arthroplasty, Replacement, Hip; Bacterem

2013
[Recurrent endocarditis due to Brevibacterium casei: case presentation and a review of the literature].
    Enfermedades infecciosas y microbiologia clinica, 2017, Volume: 35, Issue:2

    Topics: Actinomycetales Infections; Anti-Bacterial Agents; Aortic Valve Stenosis; Bacteremia; Brevibacterium

2017
Endocarditis caused by nutritionally variant streptococci: a case report and literature review.
    Le infezioni in medicina, 2012, Volume: 20, Issue:2

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Bronchitis; Carnobacteriaceae; Disease Susceptibility; Dru

2012
[Endocarditis due to Bartonella spp. Three new clinical cases and Spanish literature review].
    Enfermedades infecciosas y microbiologia clinica, 2006, Volume: 24, Issue:5

    Topics: Actinobacillus Infections; Adult; Aged; Aggregatibacter actinomycetemcomitans; Alcoholism; Animals;

2006
Gene targeting. The precise manipulation of the mammalian genome.
    Circulation research, 1993, Volume: 73, Issue:1

    Topics: Animals; Arteriosclerosis; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Cell Lin

1993

Trials

2 trials available for gentamicin and Diathesis

ArticleYear
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr

2005
Effect of antimicrobial (nalidixic acid) therapy in shigellosis and predictive values of outcome variables in patients susceptible or resistant to it.
    The Journal of tropical medicine and hygiene, 1995, Volume: 98, Issue:2

    Topics: Abdominal Pain; Anorexia; Child; Child, Preschool; Disease Susceptibility; Double-Blind Method; Dyse

1995

Other Studies

13 other studies available for gentamicin and Diathesis

ArticleYear
[Polymorphic erythema secondary to alpha hemolytic streptococcus infection in Behcet disease].
    The Pan African medical journal, 2014, Volume: 18

    Topics: Adult; Anti-Bacterial Agents; Behcet Syndrome; Cephapirin; Disease Susceptibility; Erythema Multifor

2014
All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Animals; Animals, Newborn; Cell Survival; Disease Susceptibility; Evoked Potentials, Auditory, Brain

2015
[Infective endarteritis complicating aortic coarctation in a 66-year-old woman].
    Enfermedades infecciosas y microbiologia clinica, 2010, Volume: 28, Issue:1

    Topics: Aged; Anti-Bacterial Agents; Aortic Coarctation; Bacteremia; Cardiomegaly; Ceftriaxone; Disease Susc

2010
Age-related differences in susceptibility to cisplatin-induced renal toxicity.
    Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:2

    Topics: Age Factors; Aging; Animals; Biomarkers; Child; Cisplatin; Disease Susceptibility; Gentamicins; Huma

2010
[A case of Pseudomonas mendocina endocarditis].
    Medecine et maladies infectieuses, 2011, Volume: 41, Issue:2

    Topics: Aged; Anti-Bacterial Agents; Aortic Valve Insufficiency; Atrial Fibrillation; Calcinosis; Disease Su

2011
[Infections due to Listeria monocytogenes].
    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2011, Volume: 24, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Bacteremia; Comorbidity; Disease

2011
Increased urinary excretion of albumin, hemopexin, transferrin and VDBP correlates with chronic sensitization to gentamicin nephrotoxicity in rats.
    Toxicology, 2013, Feb-08, Volume: 304

    Topics: Acute Kidney Injury; Albuminuria; Animals; Anti-Bacterial Agents; Biomarkers; Disease Susceptibility

2013
Microbiology of choledochal bile in patients with choledocholithiasis admitted to a tertiary hospital.
    Journal of gastroenterology and hepatology, 2003, Volume: 18, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Brazil; Cephalosporins; Cholangio

2003
Gentamicin increases renal susceptibility to an acute ischemic insult.
    The Journal of laboratory and clinical medicine, 1983, Volume: 101, Issue:5

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Disease Susceptibility; Electrolytes;

1983
Antibiotic prophylaxis for infective endocarditis. FDI Commission Working Group.
    International dental journal, 1994, Volume: 44, Issue:3

    Topics: Adult; Amoxicillin; Ampicillin; Anti-Bacterial Agents; Anticoagulants; Bacteremia; Child; Clindamyci

1994
[Bacterial keratitis. Report of a case].
    Enfermedades infecciosas y microbiologia clinica, 1993, Volume: 11, Issue:1

    Topics: Adult; Amikacin; Contact Lenses, Hydrophilic; Corneal Ulcer; Disease Susceptibility; Gentamicins; Hu

1993
Stool cultures obtained before liver transplantation are useful for choice of perioperative antibiotic prophylaxis.
    Transplant international : official journal of the European Society for Organ Transplantation, 1997, Volume: 10, Issue:6

    Topics: Adult; Ampicillin; Ampicillin Resistance; Antibiotic Prophylaxis; Bacterial Infections; Cholangitis;

1997
[Cross susceptibility of ototoxicity about aminoglycoside antibiotics].
    Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 1997, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Deafness; Disease Susceptibility; Family Health; Female; G

1997