gentamicin has been researched along with Diabetic Feet in 24 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diabetic foot ulcers are notoriously difficult to heal, with ulcers often becoming chronic, in many cases leading to amputation despite weeks or months of antibiotic therapy in addition to debridement and offloading." | 5.62 | Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an ( Bayliss, M; Callaghan, N; Crowther, GS; Morley, R; Noel, A; Price, B, 2021) |
| "An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI)." | 5.27 | A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection. ( Jaafar, J; Kressmann, B; Lew, D; Lipsky, BA; Malacarne, S; Toumanova, A; Uçkay, I, 2018) |
| "Calcaneal osteomyelitis has the potential to cause limb- and life-threatening complications." | 2.72 | Cancelloplasty for Treatment of Osteomyelitis of the Calcaneus: A Novel Technique and Case Report. ( Huchital, MJ; Patel, R; Saleh, A; Subik, M, 2021) |
| "Gentamicin sulfate has been proven to be active in vitro against many strains of Gram-negative and Gram-positive pathogens, yet it is often overlooked as a treatment option owing to toxicity risks associated with parenteral delivery." | 2.45 | The use of gentamycin-impregnated foam in the management of diabetic foot infections: a promising delivery system? ( Armstrong, DG; Boulton, AJ; Bowling, FL; Griffis, CD; Metcalfe, S, 2009) |
| "Diabetic foot ulcers are notoriously difficult to heal, with ulcers often becoming chronic, in many cases leading to amputation despite weeks or months of antibiotic therapy in addition to debridement and offloading." | 1.62 | Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an ( Bayliss, M; Callaghan, N; Crowther, GS; Morley, R; Noel, A; Price, B, 2021) |
| "We present a patient with Type 2 diabetes who attended clinic with a limb threatening foot infection complicated by osteomyelitis and requiring emergency surgery and antibiotic administration." | 1.43 | Calcium sulphate as a drug delivery system in a deep diabetic foot infection. ( Lopez, F; Morley, R; Webb, F, 2016) |
| "Diabetic foot ulcers are commonly complicated by bone involvement and osteomyelitis." | 1.42 | Conservative treatment in a patient with diabetic osteomyelitis: antibiotic treatment is sufficient for complete bone regeneration in selected cases. ( Frøkjær, J; Jeppesen, SM; Yderstræde, K, 2015) |
| "Calcaneal osteomyelitis is a surgical diagnosis that may be treated by local, resection or major amputation." | 1.39 | Calcanectomy: avoiding major amputation in the presence of calcaneal osteomyelitis-A case series. ( Walsh, TP; Yates, BJ, 2013) |
| "Chronic suppuration is a reverting problem in surgical practice." | 1.30 | Experience acquired by applying gentamicin-sponge. ( Faludi, S; Jakab, F; Kádár, E; Kószegi, G, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 11 (45.83) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Fletcher, J | 1 |
| Porter, R | 1 |
| Boulton, Z | 1 |
| Brown, L | 1 |
| Knight, B | 1 |
| Romanczuk, L | 1 |
| Aiken, S | 1 |
| Delury, C | 1 |
| Michell, S | 1 |
| Liu, C | 1 |
| You, JX | 1 |
| Chen, YX | 1 |
| Zhu, WF | 1 |
| Wang, Y | 1 |
| Lv, PP | 1 |
| Zhao, F | 1 |
| Li, HY | 1 |
| Li, L | 1 |
| Huchital, MJ | 1 |
| Saleh, A | 1 |
| Patel, R | 1 |
| Subik, M | 1 |
| Crowther, GS | 1 |
| Callaghan, N | 1 |
| Bayliss, M | 1 |
| Noel, A | 1 |
| Morley, R | 2 |
| Price, B | 1 |
| Drampalos, E | 1 |
| Mohammad, HR | 1 |
| Kosmidis, C | 1 |
| Balal, M | 1 |
| Wong, J | 1 |
| Pillai, A | 1 |
| Uçkay, I | 1 |
| Kressmann, B | 1 |
| Malacarne, S | 1 |
| Toumanova, A | 1 |
| Jaafar, J | 1 |
| Lew, D | 1 |
| Lipsky, BA | 1 |
| Walsh, TP | 1 |
| Yates, BJ | 1 |
| Iwakura, T | 1 |
| Lee, SY | 1 |
| Niikura, T | 1 |
| Miwa, M | 1 |
| Sakai, Y | 1 |
| Nishida, K | 1 |
| Kuroda, R | 1 |
| Kurosaka, M | 1 |
| Jogia, RM | 1 |
| Modha, DE | 1 |
| Nisal, K | 1 |
| Berrington, R | 1 |
| Kong, MF | 1 |
| Lopez, F | 1 |
| Webb, F | 1 |
| Jeppesen, SM | 1 |
| Frøkjær, J | 1 |
| Yderstræde, K | 1 |
| Mottola, C | 1 |
| Matias, CS | 1 |
| Mendes, JJ | 1 |
| Melo-Cristino, J | 1 |
| Tavares, L | 1 |
| Cavaco-Silva, P | 1 |
| Oliveira, M | 1 |
| Price, BL | 1 |
| Lovering, AM | 1 |
| Bowling, FL | 2 |
| Dobson, CB | 1 |
| Griffis, CD | 1 |
| Metcalfe, S | 1 |
| Boulton, AJ | 1 |
| Armstrong, DG | 1 |
| Désidéri-Vaillant, C | 1 |
| Nédelec, Y | 1 |
| Guichon, JM | 1 |
| Le Louarn, S | 1 |
| Noyer, V | 1 |
| Sapin-Lory, J | 1 |
| Le Guen, P | 1 |
| Nicolas, X | 1 |
| Agarwal, P | 1 |
| Agrawal, PK | 1 |
| Sharma, D | 1 |
| Baghel, KD | 1 |
| Renders, NH | 1 |
| Kluytmans, JA | 1 |
| Stolz, E | 1 |
| Verbrugh, HA | 1 |
| Bühler-Singer, S | 2 |
| Hiller, D | 2 |
| Boateng, B | 1 |
| Albrecht, HP | 2 |
| Seidel, C | 2 |
| Hornstein, OP | 2 |
| Shidlovs'kiĭ, VO | 1 |
| Liapis, MO | 1 |
| Deĭkalo, IM | 1 |
| Apelqvist, J | 1 |
| Ragnarson Tennvall, G | 1 |
| Faludi, S | 1 |
| Kádár, E | 1 |
| Kószegi, G | 1 |
| Jakab, F | 1 |
| Connolly, JE | 1 |
| Wrobel, JS | 1 |
| Anderson, RF | 1 |
| Brunner, M | 1 |
| Göring, HD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Controlled Study to Investigate the Efficacy and Safety of a Topical Gentamicin-Collagen Sponge in Combination With Systemic Antibiotic Therapy in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection[NCT01951768] | Phase 4 | 88 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Performance of Antibiotic Impregnated Calcium Sulfate: A Prospective Randomized Controlled Trial[NCT03875963] | 100 participants (Actual) | Interventional | 2020-01-01 | Terminated (stopped due to Sponsor decided not to pursue the study.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical Cure defined as the absence of any clinical, radiological or laboratory evidence of infection (NCT01951768)
Timeframe: Approximately day 38
| Intervention | participants (Number) |
|---|---|
| Garamycin Sponge (Gentamicin-Collagen Sponge) | 38 |
| Systemic Antibiotic | 39 |
Clinical significant improvement is defined as significant improvement of infection but not complete cure (e.g., residual uninfected skin lesions). (NCT01951768)
Timeframe: up to 38 days
| Intervention | participants (Number) |
|---|---|
| Garamycin Sponge (Gentamicin-Collagen Sponge) | 7 |
| Systemic Antibiotic | 13 |
Microbiological eradication of former infection (NCT01951768)
Timeframe: up to 38 days
| Intervention | participants (Number) |
|---|---|
| Garamycin Sponge (Gentamicin-Collagen Sponge) | 26 |
| Systemic Antibiotic | 20 |
2 reviews available for gentamicin and Diabetic Feet
| Article | Year |
|---|---|
Cancelloplasty for Treatment of Osteomyelitis of the Calcaneus: A Novel Technique and Case Report.
Topics: Amputation, Surgical; Anti-Bacterial Agents; Bone Substitutes; Calcaneus; Calcium Phosphates; Diabet | 2021 |
The use of gentamycin-impregnated foam in the management of diabetic foot infections: a promising delivery system?
Topics: Absorbable Implants; Administration, Topical; Anti-Bacterial Agents; Bacterial Infections; Collagen; | 2009 |
2 trials available for gentamicin and Diabetic Feet
| Article | Year |
|---|---|
A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection.
Topics: Anti-Bacterial Agents; Bandages; Collagen; Diabetic Foot; Gentamicins; Humans; Pilot Projects | 2018 |
Cavity foot ulcers in diabetic patients: a comparative study of cadexomer iodine ointment and standard treatment. An economic analysis alongside a clinical trial.
Topics: Adult; Anti-Bacterial Agents; Cost-Benefit Analysis; Diabetic Foot; Gentamicins; Humans; Iodine Comp | 1996 |
20 other studies available for gentamicin and Diabetic Feet
| Article | Year |
|---|---|
Topics: Agar; Anti-Bacterial Agents; Bacteria; Calcium Sulfate; Diabetes Mellitus; Diabetic Foot; Floxacilli | 2022 |
Effect of Induced Membrane Formation Followed by Polymethylmethacrylate Implantation on Diabetic Foot Ulcer Healing When Revascularization Is Not Feasible.
Topics: Abscess; Aged; Amputation, Surgical; Anti-Bacterial Agents; Bone Cements; Case-Control Studies; Debr | 2019 |
Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an
Topics: Anti-Bacterial Agents; Biofilms; Calcium; Calcium Sulfate; Diabetes Mellitus; Diabetic Foot; Gentami | 2021 |
Single stage treatment of diabetic calcaneal osteomyelitis with an absorbable gentamicin-loaded calcium sulphate/hydroxyapatite biocomposite: The Silo technique.
Topics: Absorbable Implants; Aged; Aged, 80 and over; Calcaneus; Calcium Sulfate; Chronic Disease; Combined | 2018 |
Calcanectomy: avoiding major amputation in the presence of calcaneal osteomyelitis-A case series.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Anti-Bacterial Agents; Calcaneus; Calcium Sulfate; De | 2013 |
Gentamycin-impregnated calcium phosphate cement for calcaneal osteomyelitis: a case report.
Topics: Anti-Bacterial Agents; Bone Cements; Calcaneus; Calcium Phosphates; Diabetic Foot; Female; Gentamici | 2014 |
Use of highly purified synthetic calcium sulfate impregnated with antibiotics for the management of diabetic foot ulcers complicated by osteomyelitis.
Topics: Adult; Aged; Anti-Bacterial Agents; Calcium Sulfate; Diabetic Foot; Disease Management; Female; Gent | 2015 |
Calcium sulphate as a drug delivery system in a deep diabetic foot infection.
Topics: Anti-Bacterial Agents; Calcium Sulfate; Diabetes Mellitus, Type 2; Diabetic Foot; Drug Delivery Syst | 2016 |
Conservative treatment in a patient with diabetic osteomyelitis: antibiotic treatment is sufficient for complete bone regeneration in selected cases.
Topics: Anti-Bacterial Agents; Diabetes Mellitus, Type 2; Diabetic Foot; Floxacillin; Gentamicins; Humans; M | 2015 |
Susceptibility patterns of Staphylococcus aureus biofilms in diabetic foot infections.
Topics: Anti-Bacterial Agents; beta-Lactams; Biofilms; Ceftaroline; Cephalosporins; Diabetic Foot; Gentamici | 2016 |
Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection.
Topics: Anti-Bacterial Agents; Biofilms; Calcium Sulfate; Collagen; Diabetic Foot; Drug Resistance, Multiple | 2016 |
Staphylococcus simulans osteitis in a diabetic patient.
Topics: Aged; Amoxicillin; Diabetic Foot; Female; Gentamicins; Humans; Osteitis; Staphylococcal Skin Infecti | 2011 |
Intravenous infusion for the treatment of diabetic and ischaemic non-healing pedal ulcers.
Topics: Adult; Case-Control Studies; Debridement; Diabetic Foot; Female; Foot; Foot Ulcer; Gentamicins; Hepa | 2005 |
[Gentamicin skin ointment: 200 kilos too much].
Topics: Aged; Anti-Bacterial Agents; Diabetes Mellitus, Type 2; Diabetic Foot; Drug Resistance, Microbial; F | 1995 |
[Disordered cutaneous microcirculation in diabetic neuropathic foot ulcer. Is modification by retrograde transvenous perfusion therapy possible?].
Topics: Adult; Aged; Blood Flow Velocity; Chemotherapy, Cancer, Regional Perfusion; Dexamethasone; Diabetic | 1995 |
Disturbances of cutaneous microcirculation in patients with diabetic legs: additional parameters for a new therapeutic concept?
Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Dexamethasone; Diabetic Angiopathies; Diabeti | 1994 |
[Antibiotic prophylaxis suppurative infections of the foot in patients with diabetes mellitus].
Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Cephalosporins; Diabetic Foot | 1996 |
Experience acquired by applying gentamicin-sponge.
Topics: Amputation, Surgical; Anti-Bacterial Agents; Chronic Disease; Delayed-Action Preparations; Diabetic | 1997 |
Primary closure of infected diabetic foot wounds. A report of closed instillation in 30 cases.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Comorbidity; Diabetic Foot; Drainage; Gentami | 2000 |
[Retrograde venous perfusion (RVP in ulcero-mutilating neuropathy].
Topics: Alcoholism; Anti-Inflammatory Agents; Anticoagulants; Dexamethasone; Diabetes Complications; Diabete | 2001 |