gentamicin has been researched along with Cystinosis in 3 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Cystinosis: A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cystinosis is an ultrarare disorder caused by mutations of the cystinosin (CTNS) gene, encoding a cystine-selective efflux channel in the lysosomes of all cells of the body." | 3.91 | The aminoglycoside geneticin permits translational readthrough of the CTNS W138X nonsense mutation in fibroblasts from patients with nephropathic cystinosis. ( Brasell, EJ; Chu, L; El Kares, R; Goodyer, P; Iglesias, DM; Loesch, R; Seo, JH, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brasell, EJ | 1 |
| Chu, L | 1 |
| El Kares, R | 1 |
| Seo, JH | 1 |
| Loesch, R | 1 |
| Iglesias, DM | 1 |
| Goodyer, P | 1 |
| Midgley, J | 1 |
| Helip-Wooley, A | 1 |
| Park, MA | 1 |
| Lemons, RM | 1 |
| Thoene, JG | 1 |
3 other studies available for gentamicin and Cystinosis
| Article | Year |
|---|---|
The aminoglycoside geneticin permits translational readthrough of the CTNS W138X nonsense mutation in fibroblasts from patients with nephropathic cystinosis.
Topics: Amino Acid Transport Systems, Neutral; Codon, Nonsense; Cystine; Cystinosis; Fibroblasts; Genetic Ve | 2019 |
A breakthrough in readthrough? Could geneticin lead the way to effective treatment for cystinosis nonsense mutations?
Topics: Amino Acid Transport Systems, Neutral; Aminoglycosides; Codon, Nonsense; Cystinosis; Fibroblasts; Ge | 2019 |
Expression of CTNS alleles: subcellular localization and aminoglycoside correction in vitro.
Topics: Alleles; Amino Acid Transport Systems, Neutral; Aminoglycosides; Anti-Bacterial Agents; Cells, Cultu | 2002 |