gentamicin has been researched along with Cystic Fibrosis of Pancreas in 157 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with cystic fibrosis who have premature stop codons, gentamicin can cause translational "read through," resulting in the expression of full-length CFTR protein at the apical cell membrane, and thus can correct the typical electrophysiological abnormalities caused by CFTR dysfunction." | 9.10 | Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. ( Aviram, M; Bdolah-Abram, T; Bebok, Z; Bentur, L; Blau, H; Kerem, B; Kerem, E; Rivlin, J; Shushi, L; Wilschanski, M; Yaacov, Y; Yahav, Y, 2003) |
| "A randomized cross-over study was undertaken to compare nebulized (1) ceftazidime with (2) a combination of gentamicin and carbenicillin, and (3) saline, each given for 4 months, in patients with cystic fibrosis infected with Pseudomonas aeruginosa." | 9.06 | Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. ( Batten, JC; Hodson, ME; Stead, RJ, 1987) |
| "A randomised controlled open comparison of azlocillin and gentamicin versus carbenicillin and gentamicin was carried out in patients with cystic fibrosis who were chronically infected with Pseudomonas aeruginosa." | 9.05 | Azlocillin compared with carbenicillin in the treatment of bronchopulmonary infection due to Pseudomonas aeruginosa in cystic fibrosis. ( Batten, JC; Gaya, H; Hodson, ME; Penketh, A, 1984) |
| "The pharmacokinetics of tobramycin in adolescents or young adults with cystic fibrosis and in age-matched controls were prospectively compared." | 9.05 | Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study. ( Koup, JR; Levy, J; Ramsey, B; Smith, AL; Williams-Warren, J, 1984) |
| "A pharmacokinetic approach was used for gentamicin dosing in 19 children and young adults with cystic fibrosis." | 9.05 | Dosing implications of altered gentamicin disposition in patients with cystic fibrosis. ( Hilman, BC; Kearns, GL; Wilson, JT, 1982) |
| "Sixteen adults with cystic fibrosis and chronic bronchopulmonary infection with Pseudomonas aeruginosa, admitted to hospital for chemotherapy, were randomized to treatment with either carbenicillin or ticarcillin." | 9.05 | Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis. ( Batten, JC; Hodson, ME; Penketh, AR, 1983) |
| "An open randomised comparison of a new intravenous cephalosporin, ceftazidime, with the established regimen of gentamicin and carbenicillin was carried out in patients with cystic fibrosis who had persisting pulmonary infection with Pseudomonas species and who developed acute exacerbations of respiratory symptoms." | 9.05 | Ceftazidime compared with gentamicin and carbenicillin in patients with cystic fibrosis, pulmonary pseudomonas infection, and an exacerbation of respiratory symptoms. British Thoracic Society Research Committee. ( , 1985) |
| "The effectiveness of ticarcillin against Pseudomonas aeruginosa in acute exacerbations of pulmonary infection in patients with cystic fibrosis was evaluated." | 9.04 | Treatment of pulmonary infections in patients with cystic fibrosis: a comparative study of ticarcillin and gentamicin. ( Denning, CR; Gaerlan, PF; Merlino, M; Neu, HC; Ores, CN; Parry, MF, 1977) |
| " Previously we have found variable efficiency of readthrough in response to the aminoglycoside gentamicin among cystic fibrosis (CF) patients, all carrying the W1282X nonsense mutation." | 7.74 | Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin. ( Boelz, S; Kerem, B; Kerem, E; Kulozik, AE; Linde, L; Neu-Yilik, G; Nissim-Rafinia, M; Oren, YS; Virgilis, D; Wilschanski, M; Yaacov, Y, 2007) |
| "Here we report the effects of gentamicin treatment on cystic fibrosis transmembrane regulator (CFTR) production and function in CF airway cells and patients with CF with premature stop mutations." | 7.71 | Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. ( Bebök, Z; Bedwell, DM; Clancy, JP; Greer, H; Hong, J; Jones, J; King, C; Lyrene, R; Macaluso, M; Ruiz, F; Sorscher, EJ; Walker, L; Wing, L, 2001) |
| "Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity." | 7.71 | Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen. ( Henry, MM; Retsch-Bogart, GZ; Scott, CS, 2001) |
| "Long-term gentamicin inhalation in patients with cystic fibrosis poses a risk of renal toxicity." | 7.70 | Urinary N-acetyl-beta-D-glucosaminidase activity in patients with cystic fibrosis on long-term gentamicin inhalation. ( Eber, E; Erwa, W; Ring, E; Zach, MS, 1998) |
| "Gentamicin serum concentrations were measured in 15 children and seven adults with cystic fibrosis and in eight children with other diseases." | 7.67 | Individualizing gentamicin dosage in patients with cystic fibrosis: limitations to pharmacokinetic approach. ( Hendeles, L; Iafrate, RP; Mangos, JA; Stillwell, PC, 1987) |
| "A study of 29 children and adolescents with cystic fibrosis over 2 years showed some evidence of benefit from the twice daily inhalation of 20 mg nebulized gentamicin when compared to the inhalation of a nebulized saline mixture." | 7.67 | Nebulized gentamicin in children and adolescents with cystic fibrosis. ( Kun, P; Landau, LI; Phelan, PD, 1984) |
| "The in vitro activity of aztreonam combined with tobramycin and with gentamicin was assessed in 78 clinical isolates of Pseudomonas aeruginosa and 11 clinical isolates of Pseudomonas cepacia from patients with cystic fibrosis." | 7.67 | In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis. ( Bosso, JA; Matsen, JM; Saxon, BA, 1987) |
| "Treatment with gentamicin or tobramycin given intravenously with carbenicillin is compared in the treatment of bronchopulmonary infection in older patients with cystic fibrosis." | 7.66 | Tobramycin and carbenicillin compared with gentamicin and carbenicillin in the treatment of infection with Pseudomonas aeruginosa in adult patients with cystic fibrosis. ( Batten, JC; Hodson, ME; Wingfield, HJ, 1983) |
| "The combination of azlocillin and gentamicin or tobramycin, in the treatment of lower respiratory tract infection due to Pseudomonas aeruginosa in patients with cystic fibrosis, was evaluated." | 7.66 | Azlocillin in cystic fibrosis. ( Alfredsson, H; Malmborg, AS; Strandvik, B, 1983) |
| "The pharmacokinetics of intravenous netilmicin was studied in cystic fibrosis (CF) and non-CF patients who were closely matched according to age." | 7.66 | Pharmacokinetics of netilmicin in children with and without cystic fibrosis. ( Bergan, T; Michalsen, H, 1981) |
| "18 children with cystic fibrosis and mucoid pseudomonas lung infection were treated with courses either of gentamicin plus carbenicillin, or tobramycin plus carbenicillin, with 2 children each receiving two courses." | 7.66 | Gentamicin and tobramycin compared in the treatment of mucoid pseudomonas lung infections in cystic fibrosis. ( Anderson, CM; George, RH; Healing, DE; Martin, AJ; Smalley, CA, 1980) |
| "Two mechanisms of potential biologic antagonism of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis were studied: reduction of activity by ions and antibiotic binding." | 7.66 | Bioactivity of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis: comparison with activity in serum. ( Kenny, MA; Levy, J; Ramsey, B; Schoenknecht, FD; Smith, AL, 1983) |
| "The levels of gentamicin in blood and in secretions of the tracheobronchial tree were measured in 14 children (8 with cystic fibrosis and 6 with tracheostomy) in a cross over fashion after the administration of 40 mg of gentamicin by aerosol or by endotracheal injection." | 7.65 | Concentration of gentamicin in bronchial secretions of children with cystic fibrosis of tracheostomy. (Comparison between the intramuscular route, the endotracheal instillation and aerosolization). ( Baran, D; Dachy, A; Klastersky, J, 1975) |
| "gentamicin) suppress nonsense mutations located in CFTR permitting translation to continue to the natural termination codon." | 6.73 | In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study. ( Bidou, L; Bismuth, E; Davy, N; Edelman, A; Fajac, A; Lenoir, G; Lesure, JF; Parbaille, B; Pierrot, S; Reinert, P; Renouil, M; Rousset, JP; Sermet-Gaudelus, I, 2007) |
| "When gentamicin was inhaled, blood concentrations were minimal, and were below concentrations known to cause systemic toxicity." | 6.69 | Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study. ( Chrystyn, H; Crowther Labiris, NR; Holbrook, AM; Macleod, SM; Newhouse, MT, 1999) |
| "Oral ciprofloxacin is a useful short-term treatment for patients with CF who are infected with Ps aeruginosa." | 6.66 | Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosis. ( Batten, JC; Butland, RJ; Hodson, ME; Roberts, CM; Smith, MJ, 1987) |
| "Nebulized gentamicin solution combined with systemic antibiotics appears to be safe and has comparable efficacy to other strategies in eradicating early Pa infections in children with CF." | 5.51 | Nebulized gentamicin in combination with systemic antibiotics for eradicating early Pseudomonas aeruginosa infection in children with cystic fibrosis. ( Morrow, BM; Van Stormbroek, B; Zampoli, M, 2019) |
| "Gentamicin was encapsulated into liposomes with different lipid compositions (1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-distearoyl-sn-glycero-3-phosphocholine) and cholesterol in the molar ratio of 2:1 by sonication." | 5.33 | Liposome-mediated gentamicin delivery: development and activity against resistant strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients. ( Azghani, AO; Mugabe, C; Omri, A, 2005) |
| "To investigate whether transient-evoked and distortion-product (DP) otoacoustic emissions (OAEs) are more sensitive than pure-tone audiometry (PTA) in revealing gentamicin-induced ototoxicity in children with cystic fibrosis (CF)." | 5.10 | Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis. ( Adamopoulos, G; Apostolopoulos, N; Dinopoulou, D; Doudounakis, S; Stavroulaki, P; Vossinakis, IC, 2002) |
| "In patients with cystic fibrosis who have premature stop codons, gentamicin can cause translational "read through," resulting in the expression of full-length CFTR protein at the apical cell membrane, and thus can correct the typical electrophysiological abnormalities caused by CFTR dysfunction." | 5.10 | Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. ( Aviram, M; Bdolah-Abram, T; Bebok, Z; Bentur, L; Blau, H; Kerem, B; Kerem, E; Rivlin, J; Shushi, L; Wilschanski, M; Yaacov, Y; Yahav, Y, 2003) |
| "A randomized cross-over study was undertaken to compare nebulized (1) ceftazidime with (2) a combination of gentamicin and carbenicillin, and (3) saline, each given for 4 months, in patients with cystic fibrosis infected with Pseudomonas aeruginosa." | 5.06 | Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. ( Batten, JC; Hodson, ME; Stead, RJ, 1987) |
| "Sixteen adults with cystic fibrosis and chronic bronchopulmonary infection with Pseudomonas aeruginosa, admitted to hospital for chemotherapy, were randomized to treatment with either carbenicillin or ticarcillin." | 5.05 | Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis. ( Batten, JC; Hodson, ME; Penketh, AR, 1983) |
| "A randomised controlled open comparison of azlocillin and gentamicin versus carbenicillin and gentamicin was carried out in patients with cystic fibrosis who were chronically infected with Pseudomonas aeruginosa." | 5.05 | Azlocillin compared with carbenicillin in the treatment of bronchopulmonary infection due to Pseudomonas aeruginosa in cystic fibrosis. ( Batten, JC; Gaya, H; Hodson, ME; Penketh, A, 1984) |
| "A pharmacokinetic approach was used for gentamicin dosing in 19 children and young adults with cystic fibrosis." | 5.05 | Dosing implications of altered gentamicin disposition in patients with cystic fibrosis. ( Hilman, BC; Kearns, GL; Wilson, JT, 1982) |
| "The pharmacokinetics of tobramycin in adolescents or young adults with cystic fibrosis and in age-matched controls were prospectively compared." | 5.05 | Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study. ( Koup, JR; Levy, J; Ramsey, B; Smith, AL; Williams-Warren, J, 1984) |
| "An open randomised comparison of a new intravenous cephalosporin, ceftazidime, with the established regimen of gentamicin and carbenicillin was carried out in patients with cystic fibrosis who had persisting pulmonary infection with Pseudomonas species and who developed acute exacerbations of respiratory symptoms." | 5.05 | Ceftazidime compared with gentamicin and carbenicillin in patients with cystic fibrosis, pulmonary pseudomonas infection, and an exacerbation of respiratory symptoms. British Thoracic Society Research Committee. ( , 1985) |
| "The effectiveness of ticarcillin against Pseudomonas aeruginosa in acute exacerbations of pulmonary infection in patients with cystic fibrosis was evaluated." | 5.04 | Treatment of pulmonary infections in patients with cystic fibrosis: a comparative study of ticarcillin and gentamicin. ( Denning, CR; Gaerlan, PF; Merlino, M; Neu, HC; Ores, CN; Parry, MF, 1977) |
| ", amikacin and tobramycin) have been shown to be tolerable and effective in the treatment of acute pulmonary exacerbations (APEs) in both pediatric and adult patients with cystic fibrosis." | 4.89 | Optimization of anti-pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: V. Aminoglycosides. ( Ampofo, K; Sherwin, CM; Spigarelli, MG; Stockmann, C; Waters, CD; Young, DC; Zobell, JT, 2013) |
| " Intravenous gentamicin is associated with increased risk of acute kidney injury, whereas intravenous tobramycin is less so." | 4.86 | Aminoglycoside use in cystic fibrosis: therapeutic strategies and toxicity. ( Prayle, A; Smyth, AR, 2010) |
| " The activities of oxacillin, fusidic acid, clindamycin, gentamicin, rifampin, vancomycin, linezolid, quinupristin-dalfopristin, daptomycin, tigecycline, moxifloxacin, telavancin, and oritavancin have been examined in THP-1 macrophages infected by a stable thymidine-dependent SCV strain in comparison with normal-phenotype and revertant isogenic strains isolated from the same cystic fibrosis patient." | 3.75 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a ( Denis, O; Nguyen, HA; Struelens, MJ; Theunis, A; Tulkens, PM; Van Bambeke, F; Vergison, A, 2009) |
| " Previously we have found variable efficiency of readthrough in response to the aminoglycoside gentamicin among cystic fibrosis (CF) patients, all carrying the W1282X nonsense mutation." | 3.74 | Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin. ( Boelz, S; Kerem, B; Kerem, E; Kulozik, AE; Linde, L; Neu-Yilik, G; Nissim-Rafinia, M; Oren, YS; Virgilis, D; Wilschanski, M; Yaacov, Y, 2007) |
| "Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity." | 3.71 | Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen. ( Henry, MM; Retsch-Bogart, GZ; Scott, CS, 2001) |
| "Here we report the effects of gentamicin treatment on cystic fibrosis transmembrane regulator (CFTR) production and function in CF airway cells and patients with CF with premature stop mutations." | 3.71 | Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. ( Bebök, Z; Bedwell, DM; Clancy, JP; Greer, H; Hong, J; Jones, J; King, C; Lyrene, R; Macaluso, M; Ruiz, F; Sorscher, EJ; Walker, L; Wing, L, 2001) |
| "Although pulmonary infections caused by Pseudomonas aeruginosa can hardly be eradicated in patients with cystic fibrosis (CF, the most common genetic disease among Caucasians), these patients are mainly treated with intravenous and nebulized tobramycin." | 3.70 | Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity. ( Paparella, MM; Schachern, PA; Sone, M, 1998) |
| "Long-term gentamicin inhalation in patients with cystic fibrosis poses a risk of renal toxicity." | 3.70 | Urinary N-acetyl-beta-D-glucosaminidase activity in patients with cystic fibrosis on long-term gentamicin inhalation. ( Eber, E; Erwa, W; Ring, E; Zach, MS, 1998) |
| "In continuous flow biofilm cultures in medium resembling cystic fibrosis bronchial secretions, Pseudomonas aeruginosa was not eradicated from biofilms by 1 week of treatment with high concentrations of ceftazidime and gentamicin, to which the strains were sensitive on conventional testing." | 3.69 | Ceftazidime, gentamicin, and rifampicin, in combination, kill biofilms of mucoid Pseudomonas aeruginosa. ( Ghani, M; Soothill, JS, 1997) |
| " A group that receives frequent aminoglycoside therapy are cystic fibrosis (CF) patients, who may receive cumulative doses of gentamicin over 200 g in their lifetime." | 3.69 | Comparison of distortion product OAE generation between a patient group requiring frequent gentamicin therapy and control subjects. ( Degg, C; Mulheran, M, 1997) |
| "A study of 29 children and adolescents with cystic fibrosis over 2 years showed some evidence of benefit from the twice daily inhalation of 20 mg nebulized gentamicin when compared to the inhalation of a nebulized saline mixture." | 3.67 | Nebulized gentamicin in children and adolescents with cystic fibrosis. ( Kun, P; Landau, LI; Phelan, PD, 1984) |
| "The in vitro activity of aztreonam combined with tobramycin and with gentamicin was assessed in 78 clinical isolates of Pseudomonas aeruginosa and 11 clinical isolates of Pseudomonas cepacia from patients with cystic fibrosis." | 3.67 | In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis. ( Bosso, JA; Matsen, JM; Saxon, BA, 1987) |
| "The authors studied 30 gentamicin-resistant and 17 gentamicin-sensitive strains of Pseudomonas aeruginosa isolated from respiratory cultures of patients with cystic fibrosis from five United States cities for the presence of plasmids, cross-resistance to other aminoglycosides, and the production of aminoglycoside-modifying enzymes." | 3.67 | Aminoglycoside resistance in Pseudomonas aeruginosa isolated from cystic fibrosis patients. ( John, JF; McNeill, WF; Twitty, JA, 1984) |
| "Gentamicin serum concentrations were measured in 15 children and seven adults with cystic fibrosis and in eight children with other diseases." | 3.67 | Individualizing gentamicin dosage in patients with cystic fibrosis: limitations to pharmacokinetic approach. ( Hendeles, L; Iafrate, RP; Mangos, JA; Stillwell, PC, 1987) |
| "Treatment with gentamicin or tobramycin given intravenously with carbenicillin is compared in the treatment of bronchopulmonary infection in older patients with cystic fibrosis." | 3.66 | Tobramycin and carbenicillin compared with gentamicin and carbenicillin in the treatment of infection with Pseudomonas aeruginosa in adult patients with cystic fibrosis. ( Batten, JC; Hodson, ME; Wingfield, HJ, 1983) |
| "The pharmacokinetics of intravenous netilmicin was studied in cystic fibrosis (CF) and non-CF patients who were closely matched according to age." | 3.66 | Pharmacokinetics of netilmicin in children with and without cystic fibrosis. ( Bergan, T; Michalsen, H, 1981) |
| "The combination of azlocillin and gentamicin or tobramycin, in the treatment of lower respiratory tract infection due to Pseudomonas aeruginosa in patients with cystic fibrosis, was evaluated." | 3.66 | Azlocillin in cystic fibrosis. ( Alfredsson, H; Malmborg, AS; Strandvik, B, 1983) |
| "18 children with cystic fibrosis and mucoid pseudomonas lung infection were treated with courses either of gentamicin plus carbenicillin, or tobramycin plus carbenicillin, with 2 children each receiving two courses." | 3.66 | Gentamicin and tobramycin compared in the treatment of mucoid pseudomonas lung infections in cystic fibrosis. ( Anderson, CM; George, RH; Healing, DE; Martin, AJ; Smalley, CA, 1980) |
| "Two mechanisms of potential biologic antagonism of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis were studied: reduction of activity by ions and antibiotic binding." | 3.66 | Bioactivity of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis: comparison with activity in serum. ( Kenny, MA; Levy, J; Ramsey, B; Schoenknecht, FD; Smith, AL, 1983) |
| "The levels of gentamicin in blood and in secretions of the tracheobronchial tree were measured in 14 children (8 with cystic fibrosis and 6 with tracheostomy) in a cross over fashion after the administration of 40 mg of gentamicin by aerosol or by endotracheal injection." | 3.65 | Concentration of gentamicin in bronchial secretions of children with cystic fibrosis of tracheostomy. (Comparison between the intramuscular route, the endotracheal instillation and aerosolization). ( Baran, D; Dachy, A; Klastersky, J, 1975) |
| "gentamicin) suppress nonsense mutations located in CFTR permitting translation to continue to the natural termination codon." | 2.73 | In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study. ( Bidou, L; Bismuth, E; Davy, N; Edelman, A; Fajac, A; Lenoir, G; Lesure, JF; Parbaille, B; Pierrot, S; Reinert, P; Renouil, M; Rousset, JP; Sermet-Gaudelus, I, 2007) |
| "When gentamicin was inhaled, blood concentrations were minimal, and were below concentrations known to cause systemic toxicity." | 2.69 | Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study. ( Chrystyn, H; Crowther Labiris, NR; Holbrook, AM; Macleod, SM; Newhouse, MT, 1999) |
| "Oral ciprofloxacin is a useful short-term treatment for patients with CF who are infected with Ps aeruginosa." | 2.66 | Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosis. ( Batten, JC; Butland, RJ; Hodson, ME; Roberts, CM; Smith, MJ, 1987) |
| "Tobramycin was given once daily or continuously to 52 patients with cystic fibrosis who in 10 days had no change in creatinine clearance or hearing despite maximum serum tobramycin concentrations of 40 mg/liter." | 2.65 | Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin. ( Bloxham, DD; Cash, HA; DiScenna, AO; Groden, DL; Grossniklaus, DA; Jacobs, MR; Klinger, JD; Luthe, MA; Powell, SH; Stern, RC; Thompson, WL, 1983) |
| " The data were compared in terms of efficacy and renal adverse effects by independent t-test and repeated measure ANOVA." | 2.44 | Comparing the Efficacy and Safety of Nebulized Gentamicin Plus Amikacin ( Baniasadi, S; Hassanzad, M; Kouhestani, F, 2024) |
| "Nebulized gentamicin solution combined with systemic antibiotics appears to be safe and has comparable efficacy to other strategies in eradicating early Pa infections in children with CF." | 1.51 | Nebulized gentamicin in combination with systemic antibiotics for eradicating early Pseudomonas aeruginosa infection in children with cystic fibrosis. ( Morrow, BM; Van Stormbroek, B; Zampoli, M, 2019) |
| " More than 95% of programs reported frequently or always using this dosing method." | 1.40 | A survey of extended-interval aminoglycoside dosing practices in United States adult cystic fibrosis programs. ( Prescott, WA, 2014) |
| "Tobramycin is an aminoglycoside antibiotic, normally used to treat Pseudomonas aeruginosa pulmonary infection in CF patients." | 1.39 | Tobramycin is a suppressor of premature termination codons. ( Altamura, N; Borgatti, M; Breveglieri, G; Castaldo, R; Finotti, A; Gambari, R; Panin, GC; Salvatori, F; Zuccato, C, 2013) |
| "Aminoglycoside concentration-time data and relevant clinical characteristics were collated from clinical pharmacokinetic databases established in Glasgow, Scotland and The Hague, The Netherlands." | 1.39 | Influence of multiple courses of therapy on aminoglycoside clearance in adult patients with cystic fibrosis. ( Alghanem, S; Paterson, I; Thomson, AH; Touw, DJ, 2013) |
| "Gentamicin was encapsulated into liposomes with different lipid compositions (1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-distearoyl-sn-glycero-3-phosphocholine) and cholesterol in the molar ratio of 2:1 by sonication." | 1.33 | Liposome-mediated gentamicin delivery: development and activity against resistant strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients. ( Azghani, AO; Mugabe, C; Omri, A, 2005) |
| " These patients would consequently be expected to be more susceptible to cochleotoxicity, a recognized side effect with single courses of aminoglycoside therapy." | 1.31 | Occurrence and risk of cochleotoxicity in cystic fibrosis patients receiving repeated high-dose aminoglycoside therapy. ( Burr, S; Degg, C; Morgan, DW; Mulheran, M; Stableforth, DE, 2001) |
| "Individualized dosage regimens have recently been recommended for patients treated with aminoglycoside antibiotics." | 1.27 | Individualized aminoglycoside dosage regimens in patients with cystic fibrosis. ( Delage, G; Desautels, L; Lamarre, A; Lapierre, JG; Lasalle, R; Legault, S; Masson, P; Spier, S, 1988) |
| "Inadequate therapeutic results in the treatment of bacterial infections in patients with Cystic Fibrosis prompted a reevaluation of pharmacokinetic parameters of orally and parenterally administered drugs in these patients." | 1.26 | [Pharmacokinetic of antibiotics in patients with mucoviscidosis (author's transl)]. ( Guggenbichler, JP; Pillwein, K; Rohrer, R; Schabel, F, 1981) |
| "Pharmacokinetic-based adjustment of individual aminoglycoside dosage regimens is currently being utilized in the clinical setting in an attempt to avoid toxicity and/or enhance efficacy." | 1.26 | Aminoglycoside dosage in pediatric patients:considerations regarding pharmacokinetic-based dose adjustment in patients requiring high versus low dose therapy. ( Leff, RD; Roberts, RJ, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (47.77) | 18.7374 |
| 1990's | 12 (7.64) | 18.2507 |
| 2000's | 43 (27.39) | 29.6817 |
| 2010's | 24 (15.29) | 24.3611 |
| 2020's | 3 (1.91) | 2.80 |
| Authors | Studies |
|---|---|
| Kouhestani, F | 1 |
| Hassanzad, M | 1 |
| Baniasadi, S | 1 |
| Kisiel, M | 1 |
| Sjölander, I | 1 |
| Klar, A | 1 |
| Asplund Stenkvist, M | 1 |
| Laurell, G | 1 |
| McHugh, DR | 1 |
| Cotton, CU | 1 |
| Hodges, CA | 1 |
| Van Stormbroek, B | 1 |
| Zampoli, M | 1 |
| Morrow, BM | 1 |
| Gabryszewski, SJ | 1 |
| Wong Fok Lung, T | 1 |
| Annavajhala, MK | 1 |
| Tomlinson, KL | 1 |
| Riquelme, SA | 1 |
| Khan, IN | 1 |
| Noguera, LP | 1 |
| Wickersham, M | 1 |
| Zhao, A | 1 |
| Mulenos, AM | 1 |
| Peaper, D | 1 |
| Koff, JL | 1 |
| Uhlemann, AC | 1 |
| Prince, A | 2 |
| Alghanem, S | 1 |
| Paterson, I | 1 |
| Touw, DJ | 1 |
| Thomson, AH | 1 |
| Altamura, N | 1 |
| Castaldo, R | 1 |
| Finotti, A | 1 |
| Breveglieri, G | 1 |
| Salvatori, F | 1 |
| Zuccato, C | 1 |
| Gambari, R | 1 |
| Panin, GC | 1 |
| Borgatti, M | 1 |
| Young, DC | 1 |
| Zobell, JT | 1 |
| Stockmann, C | 1 |
| Waters, CD | 1 |
| Ampofo, K | 1 |
| Sherwin, CM | 1 |
| Spigarelli, MG | 2 |
| Quon, BS | 1 |
| Goss, CH | 2 |
| Ramsey, BW | 1 |
| Prescott, WA | 1 |
| Zomer-van Ommen, DD | 1 |
| Vijftigschild, LA | 1 |
| Kruisselbrink, E | 1 |
| Vonk, AM | 1 |
| Dekkers, JF | 1 |
| Janssens, HM | 1 |
| de Winter-de Groot, KM | 1 |
| van der Ent, CK | 1 |
| Beekman, JM | 1 |
| Germoni, LA | 1 |
| Bremer, PJ | 1 |
| Lamont, IL | 1 |
| Hodgson, KA | 1 |
| Huynh, J | 1 |
| Ibrahim, LF | 1 |
| Sacks, B | 1 |
| Golshevsky, D | 1 |
| Layley, M | 1 |
| Spagnolo, M | 1 |
| Raymundo, CM | 1 |
| Bryant, PA | 1 |
| Danis-Wlodarczyk, K | 1 |
| Vandenheuvel, D | 1 |
| Jang, HB | 1 |
| Briers, Y | 1 |
| Olszak, T | 1 |
| Arabski, M | 1 |
| Wasik, S | 1 |
| Drabik, M | 1 |
| Higgins, G | 1 |
| Tyrrell, J | 1 |
| Harvey, BJ | 1 |
| Noben, JP | 1 |
| Lavigne, R | 1 |
| Drulis-Kawa, Z | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Dose-escalation Study to Evaluate the Pharmacokinetics of Inhaled Teicoplanin in Cystic Fibrosis Patients[NCT04176328] | Phase 1 | 12 participants (Actual) | Interventional | 2019-10-25 | Completed | ||
| Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-protocol is Identical to Study No. 0519-10-TLV- Minors' Adjusted Version[NCT02354560] | Phase 4 | 15 participants (Anticipated) | Interventional | 2015-06-30 | Not yet recruiting | ||
| Guangzhou Institute of Respiratory Disease[NCT02315547] | 120 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | |||
| Aerosolized Antibiotics in the Treatment of Ventilator Associated Pneumonia: A Pilot Study[NCT02478710] | Phase 4 | 16 participants (Actual) | Interventional | 2015-06-30 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for gentamicin and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Optimization of anti-pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: V. Aminoglycosides.
Topics: Adult; Amikacin; Aminoglycosides; Anti-Bacterial Agents; Child; Cystic Fibrosis; Disease Progression | 2013 |
Inhaled antibiotics for lower airway infections.
Topics: Administration, Inhalation; Amikacin; Amphotericin B; Anti-Bacterial Agents; Aztreonam; Ceftazidime; | 2014 |
Aminoglycoside use in cystic fibrosis: therapeutic strategies and toxicity.
Topics: Acute Kidney Injury; Aminoglycosides; Cystic Fibrosis; Dose-Response Relationship, Drug; Gentamicins | 2010 |
Gentamicin as gene therapy.
Topics: Animals; Anti-Bacterial Agents; Cystic Fibrosis; Genetic Therapy; Gentamicins; Humans; Models, Genet | 2002 |
[Anti-Pseudomonas aerosol therapy in cystic fibrosis: improvement with tobramycin].
Topics: Administration, Inhalation; Adolescent; Aerosols; Anti-Bacterial Agents; Carbenicillin; Child; Colis | 2002 |
Pharmacologic therapy for stop mutations: how much CFTR activity is enough?
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis T | 2004 |
Mutation specific therapy in CF.
Topics: Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA; Enzyme Inhibit | 2006 |
Clinical aspects of pseudomonas infections.
Topics: Agammaglobulinemia; Blood Transfusion; Burns; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combinat | 1981 |
Use of protein repair therapy in the treatment of cystic fibrosis.
Topics: Codon, Terminator; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expres | 1998 |
Technical report: precautions regarding the use of aerosolized antibiotics. Committee on Infectious Diseases and Committee on Drugs.
Topics: Administration, Inhalation; Adolescent; Adult; Anti-Bacterial Agents; Bronchoconstriction; Child; Cy | 2000 |
Gentamicin in pharmacogenetic approach to treatment of cystic fibrosis.
Topics: Animals; Anti-Bacterial Agents; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator | 2001 |
Pseudomonas aeruginosa infections.
Topics: Animals; Antibodies, Bacterial; Antineoplastic Agents; Arthritis, Infectious; Bone Diseases; Burns; | 1972 |
Cystic fibrosis: a not-so-fatal disease.
Topics: Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Diet Therapy; Dietary Fats; Drug Therap | 1974 |
18 trials available for gentamicin and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations.
Topics: Administration, Intranasal; Adolescent; Adult; Anti-Bacterial Agents; Child; Codon, Nonsense; Cross- | 2003 |
In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Cells, Cultured; Child; Chlorides; Codon, Nonsense; Cystic | 2007 |
Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis.
Topics: Adolescent; Adult; Aerosols; Carbenicillin; Chronic Disease; Clinical Trials as Topic; Cystic Fibros | 1981 |
Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study.
Topics: Adolescent; Adult; Body Surface Area; Child; Clinical Trials as Topic; Cystic Fibrosis; Female; Gent | 1984 |
Azlocillin compared with carbenicillin in the treatment of bronchopulmonary infection due to Pseudomonas aeruginosa in cystic fibrosis.
Topics: Adolescent; Adult; Azlocillin; Carbenicillin; Clinical Trials as Topic; Cystic Fibrosis; Drug Therap | 1984 |
Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin.
Topics: Adult; Animals; Anti-Bacterial Agents; Cystic Fibrosis; Dogs; Dose-Response Relationship, Drug; Drug | 1983 |
Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis.
Topics: Adolescent; Adult; Bronchial Diseases; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combination; Fe | 1983 |
Dosing implications of altered gentamicin disposition in patients with cystic fibrosis.
Topics: Adolescent; Adult; Biopharmaceutics; Body Surface Area; Body Weight; Child; Child, Preschool; Clinic | 1982 |
Is anti-Pseudomonas therapy warranted in acute respiratory exacerbations in children with cystic fibrosis?
Topics: Carbenicillin; Child; Cloxacillin; Cystic Fibrosis; Drug Therapy, Combination; Gentamicins; Humans; | 1980 |
Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study.
Topics: Aerosols; Anti-Bacterial Agents; Bronchiectasis; Chronic Disease; Cross-Over Studies; Cystic Fibrosi | 1999 |
Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis.
Topics: Adolescent; Anti-Bacterial Agents; Audiometry, Evoked Response; Audiometry, Pure-Tone; Case-Control | 2002 |
A comparative study of ticarcillin plus tobramycin versus carbenicillin plus gentamicin for the treatment of serious infections due to gram-negative bacilli.
Topics: Anti-Bacterial Agents; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combination; Gentamicins; Gram- | 1978 |
Treatment of pulmonary infections in patients with cystic fibrosis: a comparative study of ticarcillin and gentamicin.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Female; Genta | 1977 |
Ceftazidime compared with gentamicin and carbenicillin in patients with cystic fibrosis, pulmonary pseudomonas infection, and an exacerbation of respiratory symptoms. British Thoracic Society Research Committee.
Topics: Adolescent; Adult; Carbenicillin; Ceftazidime; Child; Cystic Fibrosis; Female; Gentamicins; Humans; | 1985 |
Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosis.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Azlocillin; Ciprofloxacin; Clinical Trials a | 1987 |
Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa.
Topics: Adolescent; Adult; Aerosols; Carbenicillin; Ceftazidime; Clinical Trials as Topic; Cystic Fibrosis; | 1987 |
Intensive treatment of pseudomonas chest infection in cystic fibrosis: a comparison of tobramycin and ticarcillin, and netilmicin and ticarcillin.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Drug Combinat | 1985 |
[Bronchial secretion and blood levels of gentamicin, in gentamicin treated children with mucoviscidosis].
Topics: Bronchi; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Gentamicins; Humans; In | 1973 |
126 other studies available for gentamicin and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Comparing the Efficacy and Safety of Nebulized Gentamicin Plus Amikacin
Topics: Administration, Inhalation; Amikacin; Anti-Bacterial Agents; Cross-Sectional Studies; Cystic Fibrosi | 2024 |
Development of bacterial resistance during treatment with topical gentamicin for chronic rhinosinusitis in patients with cystic fibrosis and primary ciliary dyskinesis. Retrospective case series.
Topics: Adult; Aged; Anti-Bacterial Agents; Ciliary Motility Disorders; Cystic Fibrosis; Drug Resistance, Mi | 2020 |
Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations.
Topics: Animals; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dise | 2020 |
Nebulized gentamicin in combination with systemic antibiotics for eradicating early Pseudomonas aeruginosa infection in children with cystic fibrosis.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Anti-Bacterial Agents; Child; Child, P | 2019 |
Metabolic Adaptation in Methicillin-Resistant
Topics: Acetylglucosamine; Adult; Animals; Biofilms; Bronchi; Bronchoalveolar Lavage Fluid; Cystic Fibrosis; | 2019 |
Influence of multiple courses of therapy on aminoglycoside clearance in adult patients with cystic fibrosis.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Body Height; Body Weight; Cystic Fi | 2013 |
Tobramycin is a suppressor of premature termination codons.
Topics: Anti-Bacterial Agents; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance R | 2013 |
A survey of extended-interval aminoglycoside dosing practices in United States adult cystic fibrosis programs.
Topics: Adult; Amikacin; Aminoglycosides; Anti-Bacterial Agents; Cystic Fibrosis; Disease Progression; Drug | 2014 |
Limited premature termination codon suppression by read-through agents in cystic fibrosis intestinal organoids.
Topics: Cells, Cultured; Coccidiostats; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Transmembrane Cond | 2016 |
The effect of alginate lyase on the gentamicin resistance of Pseudomonas aeruginosa in mucoid biofilms.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Cystic Fibrosis; Drug Resistance, Bacterial; Ge | 2016 |
The use, appropriateness and outcomes of outpatient parenteral antimicrobial therapy.
Topics: Adolescent; Ambulatory Care; Anti-Infective Agents; Bacterial Infections; Candidiasis; Catheterizati | 2016 |
A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections.
Topics: Animals; Bacterial Load; Biofilms; Cell Line; Cystic Fibrosis; Disease Models, Animal; Epithelial Ce | 2016 |
Should we stop using intravenous gentamicin in patients with cystic fibrosis?
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Case-Control Studies; Cystic Fibrosis; Gentamicins; Huma | 2008 |
[Don't stop me now!].
Topics: Animals; Anti-Bacterial Agents; Cystic Fibrosis; Dystrophin; Gene Deletion; Genetic Therapy; Gentami | 2008 |
Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa.
Topics: Acyl-Butyrolactones; Agrobacterium tumefaciens; Anti-Bacterial Agents; Biofilms; Cell Line; Cell Sur | 2008 |
Cystic fibrosis, aminoglycoside treatment and acute renal failure: the not so gentle micin.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Contraindications; Cystic Fibrosis; Gentamicins; Humans; | 2009 |
Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model.
Topics: Amino Acid Substitution; Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 2009 |
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Dose-Response Relationship, Drug; Fusidic Acid; G | 2009 |
The in-vitro activity of three anti-pseudomonal cephalosporins against isolates from patients with cystic fibrosis.
Topics: Anti-Bacterial Agents; Carbenicillin; Ceftazidime; Cephalosporins; Cystic Fibrosis; Drug Resistance, | 1981 |
Hearing loss in cystic fibrosis.
Topics: Adolescent; Amikacin; Anti-Bacterial Agents; Audiometry, Pure-Tone; Child; Child, Preschool; Cystic | 2010 |
Pseudomonas or LPS exposure alters CFTR iodide efflux in 2WT2 epithelial cells with time and dose dependence.
Topics: Biological Assay; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; E | 2010 |
Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations.
Topics: Aminoglycosides; Animals; Codon, Nonsense; Cystic Fibrosis; Drug Design; Genetic Diseases, Inborn; G | 2010 |
Can mucoid Pseudomonas aeruginosa be eradicated in children with cystic fibrosis?
Topics: Adolescent; Anti-Bacterial Agents; Child; Colistin; Cystic Fibrosis; Female; Gentamicins; Humans; Lo | 2010 |
Minimizing the toxicity of aminoglycosides in cystic fibrosis.
Topics: Acute Kidney Injury; Aminoglycosides; Anti-Bacterial Agents; Chronic Disease; Cystic Fibrosis; DNA, | 2010 |
Quantitative proteomics (2-D DIGE) reveals molecular strategies employed by Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients under antimicrobial therapy.
Topics: Adaptation, Physiological; Anti-Bacterial Agents; Bacterial Proteins; Burkholderia cenocepacia; Burk | 2011 |
Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.
Topics: Cell Line; Cystic Fibrosis; Gentamicins; Humans; Hydroxyquinolines; Microbial Sensitivity Tests; Mic | 2011 |
Nonsense-mediated mRNA decay and cystic fibrosis.
Topics: Alleles; Animals; Blotting, Western; Cell Line, Tumor; Chlorides; Codon, Nonsense; Cystic Fibrosis; | 2011 |
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54.
Topics: Aminoglycosides; Animals; Codon, Terminator; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2011 |
Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Cells, Cultured; Chloride Channels; Cystic Fibrosis | 2011 |
Long-term effect of chronic intravenous and inhaled nephrotoxic antibiotic treatment on the renal function of patients with cystic fibrosis.
Topics: Administration, Inhalation; Adult; Anti-Bacterial Agents; Colistin; Cystic Fibrosis; Female; Gentami | 2012 |
Gentamicin and leucine inhalable powder: what about antipseudomonal activity and permeation through cystic fibrosis mucus?
Topics: Administration, Inhalation; Anti-Infective Agents; Cystic Fibrosis; Gentamicins; Leucine; Microbial | 2013 |
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Topics: Adolescent; Adult; alpha 1-Antitrypsin; Amino Acid Chloromethyl Ketones; Anti-Bacterial Agents; Anti | 2002 |
Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.
Topics: Action Potentials; Animals; Anti-Bacterial Agents; Colforsin; Cystic Fibrosis; Cystic Fibrosis Trans | 2002 |
Acute renal failure and cystic fibrosis.
Topics: Acute Kidney Injury; Ceftazidime; Cefuroxime; Child; Cystic Fibrosis; Drug Therapy, Combination; Gen | 2003 |
Survey of resistance of Pseudomonas aeruginosa from UK patients with cystic fibrosis to six commonly prescribed antimicrobial agents.
Topics: Adult; Anti-Bacterial Agents; Ceftazidime; Ciprofloxacin; Colistin; Cystic Fibrosis; Drug Resistance | 2003 |
Pharmacologic approaches to correcting the basic defect in cystic fibrosis.
Topics: Anti-Bacterial Agents; Biological Transport; Chloride Channels; Codon, Nonsense; Cystic Fibrosis; Cy | 2003 |
Gentamicin and CFTR.
Topics: Anti-Bacterial Agents; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regula | 2003 |
Liposome-mediated gentamicin delivery: development and activity against resistant strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients.
Topics: Cystic Fibrosis; Drug Delivery Systems; Drug Resistance, Bacterial; Gentamicins; Humans; Liposomes; | 2005 |
Measurement of tobramycin and gentamicin in saliva is not suitable for therapeutic drug monitoring of patients with cystic fibrosis.
Topics: Adolescent; Anti-Bacterial Agents; Child; Cystic Fibrosis; Drug Monitoring; Gentamicins; Humans; Imm | 2005 |
Influence of gentamicin and tobramycin on binary biofilm formation by co-cultures of Burkholderia cepacia and Pseudomonas aeruginosa.
Topics: Anti-Bacterial Agents; Biofilms; Burkholderia cepacia; Cystic Fibrosis; Gentamicins; Humans; Microbi | 2005 |
Antibiotic susceptibility of Stenotrophomonas maltophilia in the presence of lactoferrin.
Topics: Anti-Bacterial Agents; Cystic Fibrosis; Drug Therapy, Combination; Gentamicins; Gram-Negative Bacter | 2005 |
Nonsense mutations: running the red light.
Topics: Animals; beta-Thalassemia; Clinical Trials, Phase II as Topic; Codon, Nonsense; Cystic Fibrosis; Gen | 2005 |
Antibacterial activity of liposomal gentamicin against Pseudomonas aeruginosa: a time-kill study.
Topics: Anti-Bacterial Agents; Cystic Fibrosis; Drug Delivery Systems; Gentamicins; Liposomes; Microbial Sen | 2006 |
Alginate lyase enhances antibiotic killing of mucoid Pseudomonas aeruginosa in biofilms.
Topics: Anti-Bacterial Agents; Biofilms; Ceftazidime; Cystic Fibrosis; Gentamicins; Humans; Microbial Sensit | 2006 |
Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model.
Topics: Amikacin; Amino Acid Sequence; Animals; Base Sequence; Codon, Nonsense; Cyclic AMP; Cystic Fibrosis; | 2006 |
Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis.
Topics: Biofilms; Bronchoalveolar Lavage Fluid; Child; Child, Preschool; Coculture Techniques; Cystic Fibros | 2006 |
CR5/20--Acute renal failure in a child with cystic fibrosis awaiting lung transplantation--a good outcome after all.
Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Ceftazidime; Cystic Fibrosis; Female; Follow | 2006 |
Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin.
Topics: Aminoglycosides; Anti-Bacterial Agents; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Transmembr | 2007 |
Restoration of W1282X CFTR activity by enhanced expression.
Topics: Amino Acid Substitution; Butyrates; Cell Line; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Tra | 2007 |
Survival in cystic fibrosis.
Topics: Aerosols; Cystic Fibrosis; Gentamicins; Humans; Infant; Respiratory Tract Infections | 1984 |
Tobramycin and carbenicillin compared with gentamicin and carbenicillin in the treatment of infection with Pseudomonas aeruginosa in adult patients with cystic fibrosis.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combination; | 1983 |
Endotoxaemia in cystic fibrosis: response to antibiotics.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Carbenicillin; Child; Cystic Fibrosis; Drug Therapy, Combi | 1983 |
Bioactivity of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis: comparison with activity in serum.
Topics: Adult; Bronchiectasis; Child; Cystic Fibrosis; Dialysis; Gentamicins; Humans; Ions; Pseudomonas aeru | 1983 |
Aminoglycoside resistance in Pseudomonas aeruginosa isolated from cystic fibrosis patients.
Topics: Aminoglycosides; Anti-Bacterial Agents; Cystic Fibrosis; Drug Resistance, Microbial; Gentamicins; Hu | 1984 |
Nebulized gentamicin in children and adolescents with cystic fibrosis.
Topics: Adolescent; Aerosols; Child; Cystic Fibrosis; Drug Resistance, Microbial; Forced Expiratory Volume; | 1984 |
Erratum: renal clearance of gentamicin in cystic fibrosis.
Topics: Cystic Fibrosis; Gentamicins; Humans; Kidney; Metabolic Clearance Rate | 1984 |
Renal clearance of gentamicin in cystic fibrosis.
Topics: Adolescent; Adult; Child; Cystic Fibrosis; Dose-Response Relationship, Drug; Female; Gentamicins; Hu | 1983 |
Azlocillin in cystic fibrosis.
Topics: Adolescent; Adult; Azlocillin; Child; Child, Preschool; Cystic Fibrosis; Drug Therapy, Combination; | 1983 |
[Microflora study and the pharmacokinetic characteristics of gentamycin in children with mucoviscidosis].
Topics: Child; Cystic Fibrosis; Dose-Response Relationship, Drug; Gentamicins; Humans; Kinetics; Microbial S | 1984 |
Gentamicin disposition in patients with cystic fibrosis: erratum.
Topics: Child; Cystic Fibrosis; Gentamicins; Humans | 1984 |
Are measurements of urine enzymes useful during aminoglycoside therapy?
Topics: Acetylglucosaminidase; Adolescent; Adult; alpha-L-Fucosidase; Aminoglycosides; beta-Galactosidase; C | 1981 |
[Role of bronchoscopy in the treatment of children with mucoviscidosis].
Topics: Bronchoscopy; Child; Child, Preschool; Cystic Fibrosis; Female; Gentamicins; Humans; Infant; Male; M | 1982 |
Activities of various beta-lactams and aminoglycosides, alone and in combination, against isolates of Pseudomonas aeruginosa from patients with cystic fibrosis.
Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; beta-Lactams; Cystic Fibrosis; Gentamicins; Humans | 1982 |
Ototoxicity of aminoglucoside antibiotics in long-term treatment for cystic fibrosis.
Topics: Adolescent; Adult; Aminoglycosides; Anti-Bacterial Agents; Child; Child, Preschool; Cystic Fibrosis; | 1980 |
Azlocillin and gentamicin in respiratory tract infections with Pseudomonas aeruginosa in patients with cystic fibrosis.
Topics: Adolescent; Adult; Azlocillin; Child; Cystic Fibrosis; Female; Gentamicins; Humans; Male; Penicillin | 1981 |
Pharmacokinetics of netilmicin in children with and without cystic fibrosis.
Topics: Child; Cystic Fibrosis; Female; Gentamicins; Humans; Kinetics; Male; Netilmicin | 1981 |
[Pharmacokinetic of antibiotics in patients with mucoviscidosis (author's transl)].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Azlocillin; Child; Cystic Fibrosis; Gentamicins; Humans; M | 1981 |
Aminoglycoside dosage in pediatric patients:considerations regarding pharmacokinetic-based dose adjustment in patients requiring high versus low dose therapy.
Topics: Adolescent; Anti-Bacterial Agents; Bacterial Infections; Child; Child, Preschool; Cystic Fibrosis; G | 1981 |
Before-assay liquification of pulmonary mucous secretions with N-acetyl-L-cysteine.
Topics: Acetylcysteine; Chemical Phenomena; Chemistry; Cystic Fibrosis; Gentamicins; Sputum | 1980 |
Gentamicin and tobramycin compared in the treatment of mucoid pseudomonas lung infections in cystic fibrosis.
Topics: Adolescent; Anti-Bacterial Agents; Carbenicillin; Child; Child, Preschool; Cystic Fibrosis; Drug The | 1980 |
Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations.
Topics: Anti-Bacterial Agents; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gentami | 1996 |
Comparison of distortion product OAE generation between a patient group requiring frequent gentamicin therapy and control subjects.
Topics: Acoustic Stimulation; Adolescent; Anti-Bacterial Agents; Audiometry, Pure-Tone; Child; Cochlea; Cyst | 1997 |
Severe haemorrhagic diathesis in an adult patient with cystic fibrosis after long-term antibiotic treatment of pulmonary infection.
Topics: Adult; Cefuroxime; Cephalosporins; Cystic Fibrosis; Follow-Up Studies; Gentamicins; Hemorrhagic Diso | 1997 |
Ceftazidime, gentamicin, and rifampicin, in combination, kill biofilms of mucoid Pseudomonas aeruginosa.
Topics: Anti-Bacterial Agents; Biofilms; Bronchi; Ceftazidime; Cephalosporins; Cystic Fibrosis; Drug Synergi | 1997 |
Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Cystic Fibrosis; Gentamicins; Hair Cells, Auditory; | 1998 |
Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; | 1998 |
Urinary N-acetyl-beta-D-glucosaminidase activity in patients with cystic fibrosis on long-term gentamicin inhalation.
Topics: Acetylglucosaminidase; Administration, Inhalation; Adolescent; Adult; Child; Child, Preschool; Cysti | 1998 |
Deposition patterns of nebulized drugs: is the pattern important?
Topics: Aerosols; Asthma; Cyclosporins; Cystic Fibrosis; Dose-Response Relationship, Drug; Gentamicins; Huma | 1994 |
Haemophilus influenzae localized in epithelial cell layers is shielded from antibiotics and antibody-mediated bactericidal activity.
Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Cell Line; Colony Count, Microbial; Cystic Fibrosis; D | 1999 |
Duchenne muscular dystrophy improved by gentamicin.
Topics: Animals; Cystic Fibrosis; Dystrophin; Female; Gentamicins; Humans; Male; Mice; Mice, Inbred mdx; Mus | 1999 |
A pilot study of the effect of gentamicin on nasal potential difference measurements in cystic fibrosis patients carrying stop mutations.
Topics: Administration, Intranasal; Adolescent; Adult; Alleles; Child; Chloride Channels; Cystic Fibrosis; C | 2000 |
Effects of amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Blotting, Norther | 2001 |
Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen.
Topics: Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cystic Fibrosis; Gentami | 2001 |
Antibiotics show promise as therapy for genetic disorders.
Topics: Animals; Anti-Bacterial Agents; Cystic Fibrosis; Gentamicins; Humans; Mice; Mice, Mutant Strains; Mu | 2001 |
Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis.
Topics: Adolescent; Adult; Cells, Cultured; Chlorides; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Tra | 2001 |
Occurrence and risk of cochleotoxicity in cystic fibrosis patients receiving repeated high-dose aminoglycoside therapy.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Audiometry, Pure-Tone; Child; Cystic Fibrosis; Deafness; D | 2001 |
Effects of inhaled gentamicin prophylaxis on acquisition of Pseudomonas aeruginosa in children with cystic fibrosis: a pilot study.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Austria; Cystic Fibrosis; Female; Gentamicins; Humans | 2002 |
Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cells.
Topics: Anti-Bacterial Agents; Bicarbonates; Bile Ducts, Intrahepatic; Calcium; Cells, Cultured; Chloride Ch | 2002 |
Bacterial-epithelial interactions.
Topics: Bacterial Adhesion; Cell Adhesion; Chemokines; Cystic Fibrosis; Cytokines; Enzyme-Linked Immunosorbe | 2002 |
Hypersensitivity to inhaled TOBI following reaction to gentamicin.
Topics: Administration, Inhalation; Anti-Bacterial Agents; Child; Cystic Fibrosis; Desensitization, Immunolo | 2002 |
Pseudomonas aeruginosa infection: pathogenesis and therapy.
Topics: Bacterial Vaccines; Burns; Carbenicillin; Cross Infection; Cystic Fibrosis; Gentamicins; Humans; Imm | 1979 |
Chemotherapy of chronic infections with mucoid Pseudomonas aeruginosa in lower airways of patients with cystic fibrosis.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Carbenicillin; Child; Child, Preschool; Chronic Disease; C | 1979 |
Multiple of isolates of Pseudomonas aeruginosa with differing antimicrobial susceptibility patterns from patients with cystic fibrosis.
Topics: Adolescent; Adult; Carbenicillin; Child; Child, Preschool; Cystic Fibrosis; Gentamicins; Humans; Inf | 1979 |
In vitro susceptibility of pseudomonas to four beta-lactamantibiotics (ampicillin, cephalothin, carbenicillin, piperacillin), to four aminoglycosides (kanamycin, amikacin, gentamicin, tobramycin) and to colimycin.
Topics: Amikacin; Aminoglycosides; Ampicillin; Carbenicillin; Cephalothin; Child; Colistin; Cystic Fibrosis; | 1979 |
Effects of sputum from patients with cystic fibrosis on the activity in vitro of 5 antimicrobial drugs on Pseudomonas aeruginosa.
Topics: Anti-Bacterial Agents; Carbenicillin; Cystic Fibrosis; Gentamicins; Humans; Microbial Sensitivity Te | 1978 |
Cystic fibrosis and hearing loss.
Topics: Acoustic Impedance Tests; Adolescent; Adult; Audiometry; Auditory Threshold; Child; Cystic Fibrosis; | 1979 |
The fecal microflora and bile acids in children with cystic fibrosis.
Topics: Anti-Bacterial Agents; Bile Acids and Salts; Carbenicillin; Child; Child, Preschool; Cloxacillin; Cy | 1979 |
Concentration of gentamicin in bronchial secretions of children with cystic fibrosis of tracheostomy. (Comparison between the intramuscular route, the endotracheal instillation and aerosolization).
Topics: Adolescent; Aerosols; Child; Child, Preschool; Cystic Fibrosis; Gentamicins; Humans; Infant; Injecti | 1975 |
Validation of therapeutic bronchoscopic bronchial washing in cystic fibrosis.
Topics: Acetylcysteine; Adolescent; Adult; Age Factors; Airway Resistance; Bronchi; Bronchoscopy; Carbenicil | 1977 |
Intrapleural injection of quinacrine for pneumothorax in a child with cystic fibrosis.
Topics: Carbenicillin; Child; Cystic Fibrosis; Gentamicins; Humans; Injections; Male; Mediastinal Emphysema; | 1976 |
Cystic fibrosis.
Topics: Adolescent; Adult; Animals; Carbenicillin; Celiac Disease; Child; Child, Preschool; Cystic Fibrosis; | 1975 |
The management of cystic fibrosis. Observations on gentamycin when used with other antibiotics in pulmonary infections associated with cystic fibrosis.
Topics: Anti-Bacterial Agents; Cystic Fibrosis; Drug Therapy, Combination; Female; Gentamicins; Humans; Lung | 1975 |
In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis.
Topics: Aztreonam; Cystic Fibrosis; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; G | 1987 |
Investigation of aminoglycoside nephrotoxicity in cystic fibrosis patients.
Topics: Acetylglucosaminidase; Adolescent; Adult; Cystic Fibrosis; Electrophoresis, Polyacrylamide Gel; Gent | 1988 |
Individualized aminoglycoside dosage regimens in patients with cystic fibrosis.
Topics: Adolescent; Amikacin; Anti-Bacterial Agents; Child; Child, Preschool; Cystic Fibrosis; Female; Genta | 1988 |
Gentamicin pharmacokinetics in cystic fibrosis.
Topics: Child; Cystic Fibrosis; Gentamicins; Half-Life; Humans; Kinetics; Time Factors | 1987 |
Quantitative deposition of aerosolized gentamicin in cystic fibrosis.
Topics: Aerosols; Calibration; Chronic Disease; Cystic Fibrosis; Gentamicins; Humans; Lung; Nebulizers and V | 1987 |
Antimicrobial chemotherapy in patients with cystic fibrosis.
Topics: Absorption; Acute Disease; Adolescent; Adult; Anti-Infective Agents; Cephalexin; Child; Child, Presc | 1987 |
Individualizing gentamicin dosage in patients with cystic fibrosis: limitations to pharmacokinetic approach.
Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Female; Gentamicins; Humans; Male | 1987 |
Pseudomonas aeruginosa in the oral cavity and sputum of patients with cystic fibrosis.
Topics: Adolescent; Adult; Carbenicillin; Child; Child, Preschool; Cystic Fibrosis; Female; Gentamicins; Hum | 1985 |
Susceptibility of mucoid Pseudomonas aeruginosa to gentamicin disks.
Topics: Cystic Fibrosis; Gentamicins; Humans; Microbial Sensitivity Tests; Pharynx; Pseudomonas aeruginosa; | 1974 |
Outpatient intravenous medications in the management of cystic fibrosis.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Child; Colistin; Cystic Fibrosis; Ge | 1974 |
Urinary acid mucopolysaccharides in cystic fibrosis.
Topics: Adolescent; Adult; Child; Chromatography, Gel; Cystic Fibrosis; Electrophoresis; Female; Gentamicins | 1971 |
An in vitro system for studying mucus secretion and other physiological activities in human intestinal mucosa.
Topics: Amphotericin B; Ampicillin; Autoradiography; Chloramphenicol; Culture Techniques; Cystic Fibrosis; G | 1970 |
Carbenicillin treatment of Pseudomonas pulmonary infection. Use in children with cystic fibrosis.
Topics: Adolescent; Alanine Transaminase; Ampicillin; Aspartate Aminotransferases; Blood Cell Count; Child; | 1970 |
Gentamicin in paediatrics.
Topics: Age Factors; Bacteria; Child; Child, Preschool; Cystic Fibrosis; Enterobacteriaceae Infections; Fema | 1974 |
Failure of bronchopulmonary lavage in cystic fibrosis.
Topics: Adult; Airway Obstruction; Cystic Fibrosis; Gentamicins; Humans; Male; Pseudomonas Infections; Sodiu | 1974 |
In vivo penetration of antibiotics into sputum in cystic fibrosis.
Topics: Acetylcysteine; Aerosols; Ampicillin; Anti-Bacterial Agents; Biological Assay; Cephaloridine; Cloxac | 1968 |
Use of carbenicillin in patients with cystic fibrosis.
Topics: Anti-Bacterial Agents; Aspartate Aminotransferases; Benzene Derivatives; Cystic Fibrosis; Gentamicin | 1970 |
Carbenicillin and gentamicin: pharmacologic studies in patients with cystic fibrosis and pseudomonas pulmonary infections.
Topics: Adolescent; Carbenicillin; Child; Child, Preschool; Cystic Fibrosis; Drug Synergism; Female; Gentami | 1971 |
Use of antibiotics in cystic fibrosis.
Topics: Carbenicillin; Cystic Fibrosis; Gentamicins; Humans; Penicillins; Pseudomonas Infections | 1972 |
Use of gentamicin in children with cystic fibrosis.
Topics: Adolescent; Adult; Aerosols; Child; Child, Preschool; Cystic Fibrosis; Drug Resistance; Gentamicins; | 1971 |
[Clinical and bacteriological study on the use of carbenicillin in the bronchopulmonary infections of mucoviscidosis].
Topics: Adolescent; Adult; Bacterial Infections; Bronchopneumonia; Carbenicillin; Child; Child, Preschool; C | 1971 |
[Use of antibiotics in pulmonary infections of mucoviscidosis].
Topics: Anti-Bacterial Agents; Carbenicillin; Cross Infection; Cystic Fibrosis; Gentamicins; Humans; Injecti | 1970 |
The differential attachment of antibiotics to glycoprotein and blood lymphocytes.
Topics: Anti-Bacterial Agents; Cloxacillin; Cystic Fibrosis; Gentamicins; Glycoproteins; Lymphocytes; Penici | 1970 |
Carbenicillin: in-vivo synergism and combined therapy.
Topics: Adolescent; Anti-Bacterial Agents; Benzene Derivatives; Burns; Child; Child, Preschool; Cystic Fibro | 1970 |