gentamicin has been researched along with Colorectal Cancer in 13 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two hundred patients with gastric, bladder, or colorectal cancer were randomized to receive preoperative PA, group A received penicillin G sodium and gentamicin and group B received clindamycin and amikacin intravenously." | 5.17 | Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery. ( El-Mahallawy, HA; El-Sayed Safa, MM; Hassan, SS; Khafagy, MM; Khalifa, HI, 2013) |
| "We compared postoperative wound infection rates in 221 colorectal surgery patients randomized to receive systemic gentamicin/metronidazole with (Group I, n = 107) or without (Group II, n = 114) the gentamicin-collagen sponge." | 2.68 | Prevention of wound infection in elective colorectal surgery by local application of a gentamicin-containing collagen sponge. ( Nijhuis, PH; Rutten, HJ, 1997) |
| "Internalization of bacteria from HIV/AIDS patients frequently resulted in partial (patients SKM1, SKM22) or complete lysis (patients SKK1-1, SKM12) of HL-60 cells." | 1.43 | Internalization property of intestinal bacteria in colon cancer and HIV/AIDS patients. ( Ciernikova, S; Majek, J; Mego, M; Stevurkova, V; Wachsmannova, L; Zajac, V, 2016) |
| " Severe obese patients need higher dosage of antibiotics." | 1.34 | [Use of antibiotics in colorectal surgery in Denmark]. ( Frimodt-Møller, N; Jensen, TG; Madsen, H; Pedersen, C; Qvist, N; Salomon, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, KY | 1 |
| Lee, J | 1 |
| Park, YY | 1 |
| Oh, ST | 1 |
| Crespo, M | 1 |
| Vilar, E | 1 |
| Tsai, SY | 1 |
| Chang, K | 1 |
| Amin, S | 1 |
| Srinivasan, T | 1 |
| Zhang, T | 1 |
| Pipalia, NH | 1 |
| Chen, HJ | 1 |
| Witherspoon, M | 1 |
| Gordillo, M | 1 |
| Xiang, JZ | 1 |
| Maxfield, FR | 1 |
| Lipkin, S | 1 |
| Evans, T | 1 |
| Chen, S | 1 |
| El-Mahallawy, HA | 1 |
| Hassan, SS | 1 |
| Khalifa, HI | 1 |
| El-Sayed Safa, MM | 1 |
| Khafagy, MM | 1 |
| Ruiz-Tovar, J | 1 |
| Llavero, C | 1 |
| Gamallo, C | 1 |
| Santos, J | 1 |
| Calpena, R | 1 |
| Arroyo, A | 1 |
| Lopez, A | 1 |
| Candela, F | 1 |
| Lv, YF | 1 |
| Wang, J | 1 |
| Dong, F | 1 |
| Yang, DH | 1 |
| Wachsmannova, L | 1 |
| Ciernikova, S | 1 |
| Majek, J | 1 |
| Mego, M | 1 |
| Stevurkova, V | 1 |
| Zajac, V | 1 |
| Bennett-Guerrero, E | 1 |
| Pappas, TN | 1 |
| Koltun, WA | 1 |
| Fleshman, JW | 1 |
| Lin, M | 1 |
| Garg, J | 1 |
| Mark, DB | 1 |
| Marcet, JE | 1 |
| Remzi, FH | 1 |
| George, VV | 1 |
| Newland, K | 1 |
| Corey, GR | 1 |
| de Bruin, AF | 1 |
| Gosselink, MP | 1 |
| Rutten, HJ | 2 |
| Puleo, S | 1 |
| Sammartino, R | 1 |
| Blandino, G | 1 |
| Tempera, G | 1 |
| Scilletta, B | 1 |
| Rodolico, G | 1 |
| Salomon, S | 1 |
| Jensen, TG | 1 |
| Qvist, N | 1 |
| Frimodt-Møller, N | 1 |
| Pedersen, C | 1 |
| Madsen, H | 1 |
| AhChong, K | 1 |
| Yip, AW | 1 |
| Lee, FC | 1 |
| Chiu, KM | 1 |
| Nijhuis, PH | 1 |
| Zelenitsky, SA | 1 |
| Silverman, RE | 1 |
| Duckworth, H | 1 |
| Harding, GK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Controlled, Phase 3 Study of Gentamicin-Collagen Sponge in General Surgical Subjects at Higher Risk for Surgical Wound Infection[NCT00600925] | Phase 3 | 602 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Application of Antibiotic Loaded Calcium Sulfate as Prophylaxis for Patients With Non Modifiable Risk Factors for Periprosthetic Joint Infections[NCT03976466] | Phase 4 | 87 participants (Actual) | Interventional | 2019-05-22 | Completed | ||
| PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery[NCT03574090] | Phase 4 | 268 participants (Actual) | Interventional | 2020-10-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of Participants who had superficial incisional surgical wound infection, based on CDC criteria adjudicated by an independent blinded committee (NCT00600925)
Timeframe: assessed at Postop Day 1, 2, 3, 7, 30 & 60
| Intervention | Participants (Count of Participants) |
|---|---|
| Gentamicin Group | 61 |
| Control | 41 |
The effect of the gentamicin-collagen sponge on rehospitalization for surgical wound infection. (NCT00600925)
Timeframe: Through 60 days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Gentamicin Group | 21 |
| Control | 13 |
Primarily, efficacy will be evaluated by a comparison between the 2 study groups of the incidence of surgical wound infections (involving the laparotomy incision) that occur within the period from surgery through postop day 60. (NCT00600925)
Timeframe: assessed at Postop Day 1, 2, 3, 7, 30 & 60
| Intervention | Participants (Count of Participants) |
|---|---|
| Gentamicin Group | 90 |
| Control | 63 |
(NCT00600925)
Timeframe: Immediate post operative period
| Intervention | days (Mean) |
|---|---|
| Gentamicin Group | 7.5 |
| Control | 7.3 |
Mean (SD) ASEPSIS Score Through 60 Days Postoperatively - brief assessment of surgical wound on post-operative Days 3, 4, 5, 6, and 7 (or discharge if earlier) and then questionnaire/phone call on post-operative Days 30 and 60. Score from each time point is added up and the mean score is reported. Used to compare antibiotic regimens for their effectiveness in preventing or treating wound sepsis, well-defined criteria for outcome are needed. A method of assessing wound healing has been devised that defines carefully the characteristics to be considered and how they are to be awarded points. Objective criteria are also included in the assessment. Points are given for the need for Additional treatment, the presence of Serous discharge, Erythema, Purulent exudate, and Separation of the deep tissues, the Isolation of bacteria, and the duration of inpatient Stay (ASEPSIS). The higher the points the worse outcome. Maximum Points would be 60. Minimum points would be 0 (NCT00600925)
Timeframe: Days 3, 4, 5, 6, and 7 (or discharge if earlier) and then questionnaire/phone call on post-operative Days 30 and 60.
| Intervention | score on a scale (Mean) |
|---|---|
| Gentamicin Group | 6.1 |
| Control | 5.2 |
The proportion of subjects who had deep incisional SWI, based on Centers for Disease Control and Prevention (CDC) criteria adjudicated by an independent blinded committee (NCT00600925)
Timeframe: assessed at Postop Day 1, 2, 3, 7, 30 & 60
| Intervention | Participants (Count of Participants) |
|---|---|
| Gentamicin Group | 25 |
| Control | 18 |
The length of stay is an important indicator of efficiency and hospital economic burden. The reduction in number of hospitalization days results in lower risk of infection and less medication side effects and decreased need of hospital supplies. The difference in the average days of hospitalization between both groups indirectly represents the economic cost spent by the hospital. (NCT03976466)
Timeframe: Surgical procedure day to hospital discharge.
| Intervention | Days (Mean) |
|---|---|
| Control Group | 15.25 |
| Calcium Sulfate Study Group | 4.6 |
1 review available for gentamicin and Colorectal Cancer
| Article | Year |
|---|---|
Meta-analysis of local gentamicin for prophylaxis of surgical site infections in colorectal surgery.
Topics: Administration, Topical; Anti-Bacterial Agents; Colonic Diseases; Colorectal Neoplasms; Gentamicins; | 2016 |
6 trials available for gentamicin and Colorectal Cancer
| Article | Year |
|---|---|
Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Clindamycin; Colorectal Neoplasms; D | 2013 |
Effect of Peritoneal Lavage with Clindamycin-Gentamicin Solution during Elective Colorectal Cancer Surgery on the Oncologic Outcome.
Topics: Adult; Aged; Anti-Bacterial Agents; Clindamycin; Colorectal Neoplasms; Female; Gentamicins; Humans; | 2016 |
Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery.
Topics: Absorbable Implants; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Colectomy; Collagen; Color | 2010 |
Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery.
Topics: Absorbable Implants; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Colectomy; Collagen; Color | 2010 |
Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery.
Topics: Absorbable Implants; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Colectomy; Collagen; Color | 2010 |
Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery.
Topics: Absorbable Implants; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Colectomy; Collagen; Color | 2010 |
Comparison of prophylactic ampicillin/sulbactam with gentamicin and metronidazole in elective colorectal surgery: a randomized clinical study.
Topics: Adult; Aged; Aged, 80 and over; Ampicillin; Colon; Colorectal Neoplasms; Colostomy; Drug Therapy, Co | 1994 |
Prevention of wound infection in elective colorectal surgery by local application of a gentamicin-containing collagen sponge.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Bacterial Agents; Collagen; Colorectal | 1997 |
A prospective, randomized, double-blind studyof single high dose versus multiple standard dose gentamicin both in combination withmetronidazole for colorectal surgicalprophylaxis.
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Colorectal Neoplasms; Di | 2000 |
6 other studies available for gentamicin and Colorectal Cancer
| Article | Year |
|---|---|
Use of gentamicin-collagen sponge (Collatamp® G) in minimally invasive colorectal cancer surgery: A propensity score-matched study.
Topics: Anti-Bacterial Agents; Colectomy; Collagen; Colorectal Neoplasms; Gentamicins; Humans; Minimally Inv | 2022 |
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.
Topics: Adenoma; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Antibiotics, Antineoplastic | 2017 |
Internalization property of intestinal bacteria in colon cancer and HIV/AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Bacteria; Colonic Neoplasms; Color | 2016 |
Gentamicin sponge for infection prophylaxis in colorectal surgery.
Topics: Anti-Bacterial Agents; Clinical Protocols; Colorectal Neoplasms; Gentamicins; Humans; Surgical Wound | 2010 |
Colorectal surgery: short-term prophylaxis with aztreonam plus clindamycin versus gentamicin plus clindamycin.
Topics: Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Aztreonam; Bacterial Infections; Clindamycin | 1989 |
[Use of antibiotics in colorectal surgery in Denmark].
Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Cefuroxime; Colore | 2007 |