gentamicin has been researched along with Cochlear Diseases in 14 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Cochlear Diseases: Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether transient-evoked and distortion-product (DP) otoacoustic emissions (OAEs) are more sensitive than pure-tone audiometry (PTA) in revealing gentamicin-induced ototoxicity in children with cystic fibrosis (CF)." | 5.10 | Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis. ( Adamopoulos, G; Apostolopoulos, N; Dinopoulou, D; Doudounakis, S; Stavroulaki, P; Vossinakis, IC, 2002) |
| "Oral supplementation with MitoQ attenuated gentamicin-induced cochlear damage and hearing loss in guinea pigs." | 3.80 | Mitochondria-targeted antioxidant MitoQ reduces gentamicin-induced ototoxicity. ( Antonelli, PJ; Le Prell, CG; Ojano-Dirain, CP, 2014) |
| "By these results, misoprostol, a potent antioxidant, has protective effect against cochlear damage, and that may be a safe alternative." | 1.46 | Protective role of misoprostol in prevention of gentamicin ototoxicity. ( Bayram, A; Dogan, M; Hira, İ; Kale, A; Karatas, D; Özcan, İ; Polat, H; Senel, F; Yasar, M, 2017) |
| "Future implementation of regenerative treatments for sensorineural hearing loss may be hindered by the lack of diagnostic tools that specify the target(s) within the cochlea and auditory nerve for delivery of therapeutic agents." | 1.38 | Mapping auditory nerve firing density using high-level compound action potentials and high-pass noise masking. ( Chertoff, ME; Earl, BR, 2012) |
| " A progressive hearing loss at high frequencies resulted from the loss of hair cells in the base of the cochlea and a constant preoccupation with finding a treatment that protects against their toxic effects." | 1.35 | Gentamicin attenuates gentamicin-induced ototoxicity - self-protection. ( de Oliveira, JA; Hyppolito, MA; Maudonnet, EN; Rossato, M, 2008) |
| "Gentamicin (12 mg/ml) was delivered via an osmotic pump into the cochlear perilymphatic space of guinea pigs at 0." | 1.33 | Inhibition of caspases alleviates gentamicin-induced cochlear damage in guinea pigs. ( Okuda, T; Shimogori, H; Sugahara, K; Takemoto, T; Yamashita, H, 2005) |
| "FCT and its ingredients could reduce the toxic damage on ear induced by gentamycin effectively." | 1.30 | [Effect of Fucong tablets and its ingredients on ototoxicity of gentamycin in guinea pigs]. ( Liu, J; Peng, B; Xu, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dogan, M | 1 |
| Polat, H | 1 |
| Yasar, M | 1 |
| Bayram, A | 1 |
| Karatas, D | 1 |
| Hira, İ | 1 |
| Kale, A | 1 |
| Senel, F | 1 |
| Özcan, İ | 1 |
| Ojano-Dirain, CP | 1 |
| Antonelli, PJ | 1 |
| Le Prell, CG | 1 |
| Earl, BR | 1 |
| Chertoff, ME | 1 |
| Yin, J | 1 |
| Zhai, S | 1 |
| Guo, W | 1 |
| Hu, Y | 1 |
| Shi, L | 1 |
| Okuda, T | 1 |
| Sugahara, K | 1 |
| Takemoto, T | 1 |
| Shimogori, H | 1 |
| Yamashita, H | 1 |
| Taylor, RR | 1 |
| Nevill, G | 1 |
| Forge, A | 1 |
| Maudonnet, EN | 1 |
| de Oliveira, JA | 1 |
| Rossato, M | 1 |
| Hyppolito, MA | 1 |
| Alles, RM | 1 |
| Pye, A | 1 |
| Park, DL | 1 |
| Girod, DA | 1 |
| Durham, D | 1 |
| Sichel, JY | 1 |
| Eliashar, R | 1 |
| Plotnik, M | 1 |
| Sohmer, H | 1 |
| Elidan, J | 1 |
| Kang, S | 1 |
| Zeng, Z | 1 |
| Shi, X | 1 |
| Xu, S | 1 |
| Peng, B | 1 |
| Liu, J | 1 |
| Guo, Y | 1 |
| Jiang, S | 1 |
| Yang, W | 1 |
| Stavroulaki, P | 1 |
| Vossinakis, IC | 1 |
| Dinopoulou, D | 1 |
| Doudounakis, S | 1 |
| Adamopoulos, G | 1 |
| Apostolopoulos, N | 1 |
1 trial available for gentamicin and Cochlear Diseases
| Article | Year |
|---|---|
Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis.
Topics: Adolescent; Anti-Bacterial Agents; Audiometry, Evoked Response; Audiometry, Pure-Tone; Case-Control | 2002 |
13 other studies available for gentamicin and Cochlear Diseases
| Article | Year |
|---|---|
Protective role of misoprostol in prevention of gentamicin ototoxicity.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Cochlea; Cochlear Diseases; Evoked Potentials, Auditor | 2017 |
Mitochondria-targeted antioxidant MitoQ reduces gentamicin-induced ototoxicity.
Topics: Animals; Antioxidants; Apoptosis; Cochlea; Cochlear Diseases; Evoked Potentials, Auditory, Brain Ste | 2014 |
Mapping auditory nerve firing density using high-level compound action potentials and high-pass noise masking.
Topics: Acoustic Stimulation; Action Potentials; Animals; Auditory Threshold; Central Nervous System Agents; | 2012 |
[Protective and rescue effects of transgenic bFGF/GFP expression mediated by cationic liposome on gentamicin-induced guinea pig cochlear toxicity].
Topics: Amines; Animals; Animals, Genetically Modified; Anti-Bacterial Agents; Cochlea; Cochlear Diseases; F | 2002 |
Inhibition of caspases alleviates gentamicin-induced cochlear damage in guinea pigs.
Topics: Administration, Topical; Amino Acid Chloromethyl Ketones; Aminoglycosides; Animals; Auditory Thresho | 2005 |
Rapid hair cell loss: a mouse model for cochlear lesions.
Topics: Age Factors; Amikacin; Animals; Anti-Bacterial Agents; Bumetanide; Cell Death; Cell Survival; Cochle | 2008 |
Gentamicin attenuates gentamicin-induced ototoxicity - self-protection.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Cochlear Diseases; Cytoprotection; Dose-Response Relationsh | 2008 |
Cochlear damage in guinea pigs following contralateral sound stimulation with and without gentamicin.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Cochlear Diseases; Ear Protective Devices; Gent | 1993 |
Evidence for loss and recovery of chick brainstem auditory neurons during gentamicin-induced cochlear damage and regeneration.
Topics: Animals; Animals, Newborn; Auditory Pathways; Brain Stem; Chickens; Cochlea; Cochlear Diseases; Gent | 1998 |
Assessment of vestibular ototoxicity of ear drops by recording of vestibular evoked potentials to acceleration impulses.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cochlear Diseases; Disease Models, Animal; | 2000 |
[Effect of electroacupuncture on succinate dehydrogenase of gentamycin induced ototoxic cochlear hair cells in guinea pigs].
Topics: Animals; Cochlea; Cochlear Diseases; Electroacupuncture; Evoked Potentials, Auditory, Brain Stem; Fe | 1998 |
[Effect of Fucong tablets and its ingredients on ototoxicity of gentamycin in guinea pigs].
Topics: Animals; Cochlea; Cochlear Diseases; Drugs, Chinese Herbal; Evoked Potentials, Auditory, Brain Stem; | 1998 |
[Experimental observation of antagonism of polyaspartic acid against gentamicin-induced phospholipidosis in cochlea of guinea pig].
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Cochlea; Cochlear Diseases; Gentamicin | 2001 |