gentamicin and Cholera Infantum studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

Excerpt	Relevance	Reference
" Patients aged 15-60 years diagnosed with uncomplicated urogenital gonorrhea were randomly assigned to either gentamicin 240 mg intramuscularly plus azithromycin 2 g orally, or gemifloxacin 320 mg orally plus azithromycin 2 g orally."	9.19	The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea. ( Ghanem, KG; Hook, EW; Johnson, S; Kerndt, PR; Kirkcaldy, RD; Moore, PC; Papp, JR; Philip, SS; Weinstock, HS; Wiesenfeld, HC, 2014)
" Patients aged 15-60 years diagnosed with uncomplicated urogenital gonorrhea were randomly assigned to either gentamicin 240 mg intramuscularly plus azithromycin 2 g orally, or gemifloxacin 320 mg orally plus azithromycin 2 g orally."	5.19	The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea. ( Ghanem, KG; Hook, EW; Johnson, S; Kerndt, PR; Kirkcaldy, RD; Moore, PC; Papp, JR; Philip, SS; Weinstock, HS; Wiesenfeld, HC, 2014)
" The prophylactic regimens significantly reduced the infectious complications, as evidenced by fewer infections, less total antibiotic dosage and shorter hospitalization."	2.65	Short term chemotherapeutic prophylaxis in gastrointestinal operations. ( Bergan, T; Christiansen, E; Fuglesang, J; Giercksky, KE; Johnson, JA, 1980)
"Necropsy revealed brain abscesses with Escherichia Coli in pure culture."	1.29	Meningoencephalitis and brain abscessation due to Escherichia coli in a 2 week old alpaca cria. ( Dvir, I; Harmelin, A; Tsur, I; Yanai, J, 1996)

Research

Studies (22)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Eradication of Pharyngeal Infection

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (68.18)	18.7374
1990's	4 (18.18)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (9.09)	24.3611
2020's	1 (4.55)	2.80

Authors	Studies
Ertürer Oruç, E	1
Albayrak, D	1
Kirkcaldy, RD	1
Weinstock, HS	1
Moore, PC	1
Philip, SS	1
Wiesenfeld, HC	1
Papp, JR	1
Kerndt, PR	1
Johnson, S	1
Ghanem, KG	1
Hook, EW	1
Burgos-Portugal, JA	1
Kaakoush, NO	1
Raftery, MJ	1
Mitchell, HM	1
Rohrbaugh, TM	1
Anolik, R	1
August, CS	1
Serota, FT	1
Koch, PA	1
Hendriks, WD	1
de Vast, J	1
van der Waaij, D	1
Dionigi, R	1
Colombo, DH	1
Nazari, S	1
Grassi, M	1
Boriolo, P	1
Venuti, M	1
Orlando, R	1
Nassuato, G	1
Martines, D	1
Lirussi, F	1
Okolicsanyi, L	1
Rotimi, VO	1
Duerden, BI	1
Eykyn, SJ	1
Giercksky, KE	1
Fuglesang, J	1
Christiansen, E	1
Johnson, JA	1
Bergan, T	1
Watine, J	1
Martorell, J	1
Bruna, T	1
Gineston, JL	1
Poirier, JL	1
Lamblin, G	1
Kallehave, F	1
Gottrup, F	1
Tsur, I	1
Harmelin, A	1
Dvir, I	1
Yanai, J	1
Farrar, WE	1
DeMaria, A	1
Buckley, H	1
von Lichtenberg, F	1
Walsh, TJ	1
Pizzo, PA	1
Di Palo, S	1
Ferrari, G	1
Castoldi, R	1
Braga, M	1
Cristallo, M	1
Staudacher, C	1
Chiesa, R	1
Di Carlo, V	1
Petrov, VI	1
Sytnik, AP	1
Lutsevich, OE	1
Istranov, LP	1
Shulman, ST	1
Amren, DP	1
Bisno, AL	1
Dajani, AS	1
Durack, DT	1
Gerber, MA	1
Kaplan, EL	1
Millard, HD	1
Sanders, WE	1
Schwartz, RH	1
VanOmmen, RA	1
Hoppes, WL	1
Lerner, PI	1
Ericson, C	1
Larsson, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Randomized Clinical Trial Evaluating the Efficacy of Gentamicin/Azithromycin and Gemifloxacin/Azithromycin Combination Therapies as an Alternative Regimen for Uncomplicated Urogenital Gonorrhea[NCT00926796]	Phase 4	614 participants (Actual)	Interventional	2010-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of enrollees with positive pharyngeal culture at enrollment who have negative culture 10-17 days after treatment (NCT00926796)
Timeframe: 10-17 days after treatment.

Eradication of Rectal Infection

Intervention	participants (Number)
Regimen A: Gentamicin Plus Azithromycin	10
Regimen B: Gemifloxacin Plus Azithromycin	15

Number of enrollees with positive rectal culture at enrollment who have negative culture 10-17 days after treatment (NCT00926796)
Timeframe: 10-17 days after treatment.

Microbiological Efficacy of Gemifloxacin and Azithromycin for the Treatment of Uncomplicated Gonococcal Infection

Intervention	participants (Number)
Regimen A: Gentamicin Plus Azithromycin	1
Regimen B: Gemifloxacin Plus Azithromycin	5

Percentage of enrollees negative by culture at cervix/urethra 10-17 days after treatment, regardless of history of re-exposure, among those with positive gonococcal cultures at enrollment (microbiological cure) (NCT00926796)
Timeframe: 10-17 days after treatment.

Microbiological Efficacy of Gentamicin and Azithromycin for the Treatment of Uncomplicated Gonococcal Infection

Intervention	percentage of participants (Number)
Regimen B: Gemifloxacin Plus Azithromycin	99.50

Number of Participants With Adverse Events for Each Regimen

Intervention	percentage of participants (Number)
Regimen A: Gentamicin Plus Azithromycin	100

Number of treated participants experiencing mild, moderate, severe, or life-threatening adverse events (AEs) either temporarily associated or not associated with study product. (NCT00926796)
Timeframe: Day 0 through Day 30

Resolution of Symptoms and Signs (Clinical Cure)

Intervention	participants (Number)
Regimen A: Gentamicin Plus Azithromycin	157
Regimen B: Gemifloxacin Plus Azithromycin	185

Number of participants whose gonorrhea-related symptoms (e.g. vaginal/urethral discharge, dysuria, dyspareunia) present at enrollment has resolved by visit 2. (NCT00926796)
Timeframe: 10-17 days after treatment.

Antimicrobial Susceptibility Profile of Enrollment Isolates.

Intervention	participants (Number)
Regimen A: Gentamicin Plus Azithromycin	179
Regimen B: Gemifloxacin Plus Azithromycin	177

Minimum inhibitory concentration (micrograms/milliliter) of pretreatment gonorrhea isolates collected from participants (NCT00926796)
Timeframe: Isolates obtained at enrollment (Day 0).

Antimicrobial Susceptibility Profile of Treatment Failures.

Intervention	micrograms/milliliter (Median)
	Azithromycin	Cefixime	Ceftriaxone	Ciprofloxacin	Gemifloxacin	Gentamicin	Penicillin	Tetracycline
Baseline	0.25	0.015	0.008	0.004	0.004	4	0.5	0.5

For treatment failures (i.e., participants with positive culture at cervix/urethra 10-17 days after treatment), the minimum inhibitory concentrations for various antimicrobial agents (Azithromycin, Cefixime, Ceftriaxone, Ciprofloxacin, Gemifloxacin, Gentamicin, Penicillin, Tetracycline). (NCT00926796)
Timeframe: Isolates obtained at enrollment (Day 0).

Clinical Profile of Treatment Failures.

Intervention	micrograms/milliliter (Median)
	Azithromycin	Cefixime	Ceftriaxone	Ciprofloxacin	Gemifloxacin	Gentamicin	Penicillin	Tetracycline
Regimen B: Gemifloxacin Plus Azithromycin	0.25	0.015	0.004	0.002	0.004	4	0.5	0.25

For treatment failures (i.e., participants with positive culture at cervix/urethra 10-17 days after treatment), number participants with clinical symptoms (vaginal/urethral discharge, dysuria, dyspareunia) at 10-17 days. (NCT00926796)
Timeframe: 10-17 days

Article	Year
The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Oct-15, Volume: 59, Issue:8 Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Azithromycin; Drug Therapy, Combinat	2014
Short term chemotherapeutic prophylaxis in gastrointestinal operations. Surgery, gynecology & obstetrics, 1980, Volume: 151, Issue:3 Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Clindamycin; Digestive System Surgical Procedure	1980

Article	Year
Impact of Gentamicin-Impregnated Collagen on the Intra-Abdominal Adhesions and Integrity of Colonic Anastomosis: An Experimental Study. Medical science monitor : international medical journal of experimental and clinical research, 2021, Jul-04, Volume: 27 Topics: Anastomosis, Surgical; Animals; Collagen; Colon; Gastrointestinal Diseases; Gentamicins; Rats; Rats,	2021
Pathogenic potential of Campylobacter ureolyticus. Infection and immunity, 2012, Volume: 80, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Adhesion; Bacterial Proteins; Caco-2 Cells; Campylobacter; Campylob	2012
Absorption of oral aminoglycosides following bone marrow transplantation. Cancer, 1984, Apr-01, Volume: 53, Issue:7 Topics: Adolescent; Adult; Aminoglycosides; Bone Marrow Transplantation; Child; Combined Modality Therapy; F	1984
Recontamination after gastrointestinal decontamination with non-absorbable antibiotics. Infection, 1981, Volume: 9, Issue:5 Topics: Absorption; Ampicillin; Animals; Anti-Bacterial Agents; Cephalothin; Decontamination; Enterococcus f	1981
[Treatment of infections in the postoperative period in high risk patients]. Minerva chirurgica, 1982, Jun-15, Volume: 37, Issue:11 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Child; Child, Preschool; Clind	1982
[Therapeutic effectiveness of metossimine associated with an aminoglycoside in a case of severe gram-negative sepsis]. La Clinica terapeutica, 1981, Apr-15, Volume: 97, Issue:1 Topics: Cefuroxime; Cephalosporins; Diabetes Complications; Drug Therapy, Combination; Escherichia coli Infe	1981
The bacterial flora of neonates with congenital abnormalities of the gastro-intestinal tract. The Journal of hygiene, 1982, Volume: 88, Issue:1 Topics: Bacteria; Bacterial Infections; Cephradine; Digestive System; Digestive System Abnormalities; Digest	1982
The microbiology of postoperative bacteremia. World journal of surgery, 1982, Volume: 6, Issue:3 Topics: Adolescent; Adult; Aged; Ampicillin; Child; Child, Preschool; Female; Gastrointestinal Diseases; Gen	1982
In vivo pefloxacin-resistant Campylobacter fetus responsible for gastro-intestinal infection and bacteremia associated with arthritis of the hip. Yonsei medical journal, 1995, Volume: 36, Issue:2 Topics: Arthritis, Infectious; Bacteremia; Campylobacter fetus; Campylobacter Infections; Drug Resistance, M	1995
Topical antibiotics used in the treatment of complex wounds. Journal of wound care, 1996, Volume: 5, Issue:4 Topics: Adult; Anti-Bacterial Agents; Bandages; Collagen; Female; Gastrointestinal Diseases; Gentamicins; Hu	1996
Meningoencephalitis and brain abscessation due to Escherichia coli in a 2 week old alpaca cria. Australian veterinary journal, 1996, Volume: 74, Issue:6 Topics: Aging; Animals; Anorexia; Anti-Bacterial Agents; Anti-Inflammatory Agents; Brain; Brain Abscess; Cam	1996
Gastrointestinal candidiasis in rats treated with antibiotics, cortisone, and azathioprine. Infection and immunity, 1976, Volume: 13, Issue:6 Topics: Animals; Antibodies, Fungal; Candida albicans; Candidiasis; Chloramphenicol; Cortisone; Feces; Femal	1976
Experimental gastrointestinal and disseminated candidiasis in immunocompromised animals. European journal of epidemiology, 1992, Volume: 8, Issue:3 Topics: Animals; Candida albicans; Candidiasis; Cytarabine; Disease Models, Animal; Female; Gastrointestinal	1992
Effectiveness of antibiotic prophylaxis according to the nutritional status in patients undergoing contaminated procedures. The Italian journal of surgical sciences, 1988, Volume: 18, Issue:3 Topics: Adolescent; Adult; Aged; Clindamycin; Female; Gastrointestinal Diseases; Gentamicins; Humans; Length	1988
[Use of a multi-component collagen preparation and low-frequency ultrasonics in gastrointestinal surgery]. Khirurgiia, 1986, Issue:3 Topics: Adult; Aged; Collagen; Drug Implants; Female; Gastrointestinal Diseases; Gentamicins; Humans; Male;	1986
Prevention of bacterial endocarditis. A statement for health professionals by the Committee on Rheumatic Fever and Bacterial Endocarditis of the Council on Cardiovascular Diseases in the Young of the American Heart Association. American journal of diseases of children (1960), 1985, Volume: 139, Issue:3 Topics: American Hospital Association; Ampicillin; Anti-Bacterial Agents; Cardiac Surgical Procedures; Denti	1985
Untoward effects of antimicrobial agents on major organ systems. The Medical clinics of North America, 1974, Volume: 58, Issue:3 Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia;	1974
Nonenterococcal group-D streptococcal endocarditis caused by Streptococcus bovis. Annals of internal medicine, 1974, Volume: 81, Issue:5 Topics: Adult; Aged; Ampicillin; Cephalosporins; Child; Chloramphenicol; Drug Therapy, Combination; Endocard	1974
Methicillin-resistant staphylococci as an epidemiological indication for gentamicin therapy. Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology, 1973 Topics: Administration, Oral; Carrier State; Denmark; Drug Therapy, Combination; Evaluation Studies as Topic	1973

gentamicin and Cholera Infantum