gentamicin has been researched along with Bronchiectasis in 17 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Bronchiectasis: Persistent abnormal dilatation of the bronchi.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized controlled trial assessing the efficacy of nebulized gentamicin therapy over 1 year in patients with non-cystic fibrosis bronchiectasis." | 9.15 | A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. ( Chalmers, JD; Doherty, CJ; Govan, JR; Greening, AP; Haslett, C; Hill, AT; Murray, MP; Simpson, AJ; Wilkinson, TS, 2011) |
| "Two mechanisms of potential biologic antagonism of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis were studied: reduction of activity by ions and antibiotic binding." | 7.66 | Bioactivity of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis: comparison with activity in serum. ( Kenny, MA; Levy, J; Ramsey, B; Schoenknecht, FD; Smith, AL, 1983) |
| "When gentamicin was inhaled, blood concentrations were minimal, and were below concentrations known to cause systemic toxicity." | 6.69 | Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study. ( Chrystyn, H; Crowther Labiris, NR; Holbrook, AM; Macleod, SM; Newhouse, MT, 1999) |
| " A 53-year-old man admitted for recurrent infective exacerbations of chronic bronchiectasis already colonized with Pseudomonas aeruginosa was treated intermittently with intravenous gentamicin (320 to 560 mg/d) for a total of 4 months to a total cumulative dose of 9." | 3.73 | Aminoglycoside-associated Fanconi syndrome. ( Ghiculescu, RA; Kubler, PA, 2006) |
| "Two mechanisms of potential biologic antagonism of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis were studied: reduction of activity by ions and antibiotic binding." | 3.66 | Bioactivity of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis: comparison with activity in serum. ( Kenny, MA; Levy, J; Ramsey, B; Schoenknecht, FD; Smith, AL, 1983) |
| "The gentamicin levels in the lung tissue and blood serum of children operated on for bronchiectasis, destructive pneumonia and pleural tumors were studied." | 3.66 | [Gentamicin concentration in the blood and lung tissue of children with bronchopulmonary pathology]. ( Bodunkova, LE; Epifantseva, MA; Matveeva, ES; Sakharova, AE, 1981) |
| "When gentamicin was inhaled, blood concentrations were minimal, and were below concentrations known to cause systemic toxicity." | 2.69 | Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study. ( Chrystyn, H; Crowther Labiris, NR; Holbrook, AM; Macleod, SM; Newhouse, MT, 1999) |
| "Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation of the smaller airways and associated with a mortality rate greater than twice that of the general population." | 2.58 | Dual antibiotics for bronchiectasis. ( Armstrong, R; Felix, LM; Grundy, S; Harrison, H; Lynes, D; Milan, SJ; Spencer, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Sogkas, G | 1 |
| Adriawan, IR | 1 |
| Ringshausen, FC | 1 |
| Baumann, U | 1 |
| Schröder, C | 1 |
| Klemann, C | 1 |
| von Hardenberg, S | 1 |
| Schmidt, G | 1 |
| Bernd, A | 1 |
| Jablonka, A | 1 |
| Ernst, D | 1 |
| Schmidt, RE | 1 |
| Atschekzei, F | 1 |
| Felix, LM | 1 |
| Grundy, S | 1 |
| Milan, SJ | 1 |
| Armstrong, R | 1 |
| Harrison, H | 1 |
| Lynes, D | 1 |
| Spencer, S | 1 |
| Cartlidge, MK | 1 |
| Smith, MP | 1 |
| Bedi, P | 1 |
| Donaldson, S | 1 |
| Clarke, A | 1 |
| Mantoani, LC | 1 |
| Rabinovich, RA | 1 |
| Rossi, AG | 1 |
| Hill, AT | 2 |
| Crowley, S | 1 |
| Matthews, I | 1 |
| Murray, MP | 1 |
| Govan, JR | 1 |
| Doherty, CJ | 1 |
| Simpson, AJ | 1 |
| Wilkinson, TS | 1 |
| Chalmers, JD | 1 |
| Greening, AP | 1 |
| Haslett, C | 1 |
| Serisier, DJ | 1 |
| Bowler, SD | 1 |
| Twiss, J | 1 |
| Byrnes, C | 1 |
| Johnson, R | 1 |
| Holland, D | 1 |
| Ghiculescu, RA | 1 |
| Kubler, PA | 1 |
| Levy, J | 1 |
| Smith, AL | 1 |
| Kenny, MA | 1 |
| Ramsey, B | 1 |
| Schoenknecht, FD | 1 |
| Sakharova, AE | 1 |
| Matveeva, ES | 1 |
| Epifantseva, MA | 1 |
| Bodunkova, LE | 1 |
| Lin, HC | 1 |
| Cheng, HF | 1 |
| Wang, CH | 1 |
| Liu, CY | 1 |
| Yu, CT | 1 |
| Kuo, HP | 1 |
| Melani, AS | 1 |
| Di Gregorio, A | 1 |
| Crowther Labiris, NR | 1 |
| Holbrook, AM | 1 |
| Chrystyn, H | 1 |
| Macleod, SM | 1 |
| Newhouse, MT | 1 |
| Aoyagi, T | 1 |
| Kawai, T | 1 |
| Yamada, Y | 1 |
| Gomi, J | 1 |
| Ogiwara, K | 1 |
| Velluti, G | 1 |
| Ovcharenko, SI | 1 |
| Loginov, LE | 1 |
| Zavodnov, VIa | 1 |
| Pines, A | 1 |
| Raafat, H | 1 |
| Siddiqui, GM | 1 |
| Greenfield, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Can Long Term Nebulised Gentamicin Reduce The Bacterial Burden, Break the Vicious Cycle of Inflammation and Improve Quality of Life in Patients With Bronchiectasis[NCT00749866] | Phase 4 | 60 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Aerosolized Antibiotics in the Treatment of Ventilator Associated Pneumonia: A Pilot Study[NCT02478710] | Phase 4 | 16 participants (Actual) | Interventional | 2015-06-30 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for gentamicin and Bronchiectasis
| Article | Year |
|---|---|
Dual antibiotics for bronchiectasis.
Topics: Adult; Anti-Bacterial Agents; Bronchiectasis; Ciprofloxacin; Gentamicins; Humans; Middle Aged; Pseud | 2018 |
4 trials available for gentamicin and Bronchiectasis
| Article | Year |
|---|---|
A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.
Topics: Administration, Inhalation; Aerosols; Aged; Anti-Bacterial Agents; Bronchiectasis; Female; Follow-Up | 2011 |
Inhaled gentamicin reduces airway neutrophil activity and mucus secretion in bronchiectasis.
Topics: Administration, Inhalation; Aged; Anti-Bacterial Agents; Bronchi; Bronchiectasis; Double-Blind Metho | 1997 |
Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study.
Topics: Aerosols; Anti-Bacterial Agents; Bronchiectasis; Chronic Disease; Cross-Over Studies; Cystic Fibrosi | 1999 |
Treatment of severe pseudomonas infections of the bronchi.
Topics: Aerosols; Aged; Bronchial Diseases; Bronchiectasis; Clinical Trials as Topic; Colistin; Gentamicins; | 1970 |
12 other studies available for gentamicin and Bronchiectasis
| Article | Year |
|---|---|
A novel NFKBIA variant substituting serine 36 of IκBα causes immunodeficiency with warts, bronchiectasis and juvenile rheumatoid arthritis in the absence of ectodermal dysplasia.
Topics: Adult; Arthritis, Juvenile; Azithromycin; Bronchiectasis; Cell Proliferation; Cells, Cultured; Child | 2020 |
Validation of the Incremental Shuttle Walk Test as a Clinical End Point in Bronchiectasis.
Topics: Aged; Anti-Bacterial Agents; Area Under Curve; Bronchiectasis; Drug Monitoring; Exercise Tolerance; | 2018 |
Resolution of extensive severe bronchiectasis in an infant.
Topics: Anti-Bacterial Agents; Bronchiectasis; Ceftazidime; Female; Gentamicins; Humans; Infant; Oxygen Inha | 2010 |
Randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis...without patient blinding.
Topics: Anti-Bacterial Agents; Bronchiectasis; Female; Gentamicins; Humans; Male | 2012 |
Nebulised gentamicin-suitable for childhood bronchiectasis.
Topics: Adolescent; Bronchiectasis; Child; Child, Preschool; Gentamicins; Humans; Hydrogen-Ion Concentration | 2005 |
Aminoglycoside-associated Fanconi syndrome.
Topics: Anti-Bacterial Agents; Bronchiectasis; Chronic Disease; Diagnosis, Differential; Fanconi Syndrome; G | 2006 |
Bioactivity of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis: comparison with activity in serum.
Topics: Adult; Bronchiectasis; Child; Cystic Fibrosis; Dialysis; Gentamicins; Humans; Ions; Pseudomonas aeru | 1983 |
[Gentamicin concentration in the blood and lung tissue of children with bronchopulmonary pathology].
Topics: Absorption; Adolescent; Bronchiectasis; Child; Child, Preschool; Gentamicins; Humans; Injections, In | 1981 |
Acute respiratory failure due to gentamicin aerosolization.
Topics: Administration, Inhalation; Aerosols; Aged; Anti-Bacterial Agents; Bronchiectasis; Gentamicins; Huma | 1998 |
[Studies on the therapeutic effects of lividomycin in respiratory infections (author's transl)].
Topics: Acute Disease; Adult; Bronchiectasis; Bronchitis; Chronic Disease; Female; Gentamicins; Humans; In V | 1975 |
[Recent studies on the in vivo and in vitro activity of gentamicin].
Topics: Acinetobacter; Adult; Aged; Bronchiectasis; Bronchitis; Drug Evaluation; Gentamicins; Humans; Klebsi | 1975 |
[Antibiotic therapy of suppurative-inflammatory lesions of the bronchi with endobronchial use of low-frequency ultrasonic energy].
Topics: Adolescent; Adult; Aerosols; Aged; Bronchi; Bronchiectasis; Bronchitis; Combined Modality Therapy; E | 1991 |