gentamicin and Bone Inflammation studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

Excerpt	Relevance	Reference
"In 10 cases of posttraumatic osteitis or osteomyelitis gentamicin-PMMA minichains have been used for treatment after radical local debridement."	3.67	[Medium term results of treatment of post-traumatic osteitis and osteomyelitis with gentamycin-PMMA minichains]. ( Quell, M; Vécsei, V, 1986)
"Surgical treatment is sufficient in septic arthritis and osteomyelitis of the hand."	2.47	[Arthritis and osteitis at the hand]. ( Meier, R; Pillukat, T, 2011)
"The acute frontal sinusitis is the most frequent cause."	1.29	[Intracranial and cranial complications of paranasal sinusitis. Report of 4 cases at the Lomé University Hospital Center]. ( Kpemissi, E; Mathias, A; Sossou, K, 1995)
"The most serious complications in the treatment of open fractures and after procedures on bone tissue are infections."	1.28	[Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma]. ( Kateusz, J; Misterka, S, 1992)
"Gentamicin balls were used for 21 children including 18 newborns and babies."	1.28	[Use of septopal in treatment of acute blood-borne inflammation of bones in children]. ( Bagłaj, M; Czernik, J; Szmida, A, 1992)

Research

Studies (34)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Number of Participants With Sternal Wound Infection or Sternal Instability/Non-union

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (58.82)	18.7374
1990's	9 (26.47)	18.2507
2000's	2 (5.88)	29.6817
2010's	3 (8.82)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Zawadzki, PJ	1
Perkowski, K	1
Kotlarski, M	1
Pietruczuk-Padzik, A	1
Chomicz, L	1
Meier, R	1
Pillukat, T	1
Désidéri-Vaillant, C	1
Nédelec, Y	1
Guichon, JM	1
Le Louarn, S	1
Noyer, V	1
Sapin-Lory, J	1
Le Guen, P	1
Nicolas, X	1
Rauschmann, MA	1
Wichelhaus, TA	1
Stirnal, V	1
Dingeldein, E	1
Zichner, L	1
Schnettler, R	1
Alt, V	1
Friberg, O	1
Svedjeholm, R	1
Söderquist, B	1
Granfeldt, H	1
Vikerfors, T	1
Källman, J	1
Borderon, E	1
Sillion, D	1
Delplace, J	1
Klifa, G	1
Trollfors, B	1
Suurkula, M	1
Price, JD	1
Norrby, R	1
Rodeheaver, GT	1
Rukstalis, D	1
Bono, M	1
Bellamy, W	1
Rémy, R	1
Malka, G	1
Piganiol, G	2
Mosser, JJ	2
Lépine, J	1
Vécsei, V	2
Starlinger, M	1
Regnard, PJ	1
Trouilloud, P	1
Günal, I	1
Seber, S	1
Kiraz, N	1
Türkay, S	1
Oztuna, V	1
Gökturk, E	1
Santschi, EM	1
Adams, SB	1
Fessler, JF	1
Widmer, WR	1
Kpemissi, E	1
Mathias, A	1
Sossou, K	1
Wahlig, H	1
Jenny, G	1
Taglang, G	1
Klemm, K	1
Politowski, M	1
Graniczny, A	1
Jonkisz, J	1
Hańce, J	1
Misterka, S	4
Kateusz, J	2
Moroń, K	1
Dorobisz, U	1
Skiba, K	1
Szmida, A	1
Czernik, J	1
Bagłaj, M	1
Feil, J	1
Bohnet, S	1
Neugebauer, R	2
Rübenacker, S	1
Burri, C	1
Quell, M	1
Eggers, C	1
Wolter, D	1
Schmidt, HU	1
Schmidt, HG	1
Weise, K	1
Müller, HP	1
Salvati, EA	1
Callaghan, JJ	1
Brause, BD	1
Klein, RF	1
Small, RD	1
Sunila, R	1
Pöntynen, S	1
Linquette, M	1
Benoit, G	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery[NCT03574090]	Phase 4	268 participants (Actual)	Interventional	2020-10-20	Completed
Local Application of Collagen-Gentamicin in Addition to Fixation of the Sternum With Extra Sternal Wires for Prevention of Sternal Wound Infection in Cardiac Surgery[NCT00484055]		1,358 participants (Actual)	Interventional	2007-01-31	Completed
Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery[NCT04238923]	Phase 2/Phase 3	356 participants (Anticipated)	Interventional	2020-05-01	Not yet recruiting
A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications.[NCT00638014]	Phase 4	51 participants (Actual)	Interventional	2008-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The Data and Safety Monitoring Board reviewed source documents for all cases with possible sternal wound infection and sternal instability or non-union and made a determination as to the presence of these complications. (NCT00638014)
Timeframe: Up to 180 days

Percentage Change of Preoperative Incentive Spirometry (IS) Volume Achieved

Intervention	Participants (Number)
Conventional Wires Only	1
Talon	1

Maximum incentive spirometry volume was measured at baseline (prior to surgery) and daily from postoperative day 1 through postoperative day 7 (or discharge if earlier) using a Coach 2 incentive spirometer with one way valve (Coach 2 model # 22-4000, Smiths Medical, Keene, NH). (NCT00638014)
Timeframe: Baseline, Maximum value during postoperatively days 1 thru 7

Article	Year
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Pr	2005
[Clinical experiences in the application of gentamycin-PMMA-spheres and chains in 134 cases of bone and soft tissue infections in Strasbourg]. Aktuelle Probleme in Chirurgie und Orthopadie, 1979, Issue:12 Topics: Clinical Trials as Topic; Evaluation Studies as Topic; Follow-Up Studies; Gentamicins; Humans; Methy	1979

Article	Year
Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton. Annals of agricultural and environmental medicine : AAEM, 2017, May-11, Volume: 24, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Collagen; Craniofacia	2017
Staphylococcus simulans osteitis in a diabetic patient. Diabetes & metabolism, 2011, Volume: 37, Issue:6 Topics: Aged; Amoxicillin; Diabetic Foot; Female; Gentamicins; Humans; Osteitis; Staphylococcal Skin Infecti	2011
Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections. Biomaterials, 2005, Volume: 26, Issue:15 Topics: Absorbable Implants; Anti-Bacterial Agents; Biocompatible Materials; Calcium Sulfate; Cell Line; Cel	2005
[Proceedings of the symposium on "Clinical Applications of Septopal", Wrocław, December 8th, 1981]. Polimery w medycynie, 1983, Volume: 13, Issue:1-2 Topics: Gentamicins; Humans; Methylmethacrylates; Osteitis	1983
[Treatment of bone infections with gentamicin-containing acrylic cement beads. Prognostic value of the study of the suction drainage fluid]. Pathologie-biologie, 1984, Volume: 32, Issue:5 Topics: Adult; Aged; Drug Implants; Female; Gentamicins; Humans; Male; Methylmethacrylates; Middle Aged; Ort	1984
Renal function during cefuroxime treatment in patients with pre-existing renal impairment. The Journal of antimicrobial chemotherapy, 1980, Volume: 6, Issue:5 Topics: Cefuroxime; Cephaloridine; Cephalosporins; Edetic Acid; Furosemide; Gentamicins; Glomerular Filtrati	1980
A new model of bone infection used to evaluate the efficacy of antibiotic-impregnated polymethylmethacrylate cement. Clinical orthopaedics and related research, 1983, Issue:178 Topics: Animals; Bone Cements; Colistin; Drug Therapy, Combination; Erythromycin; Femur; Gentamicins; Methyl	1983
[Post-fracture osteitis of the mandible and gentamicin acrylic cement pellets (author's transl)]. Revue de stomatologie et de chirurgie maxillo-faciale, 1981, Volume: 82, Issue:6 Topics: Acrylates; Adult; Dental Cements; Fracture Fixation, Internal; Gentamicins; Humans; Male; Mandibular	1981
Gentamycin-PMMA bead chains in the treatment of posttraumatic osseous and tissue infections. Archives of orthopaedic and traumatic surgery. Archiv fur orthopadische und Unfall-Chirurgie, 1982, Volume: 99, Issue:4 Topics: Adolescent; Adult; Aged; Bacterial Infections; Connective Tissue Diseases; Drug Implants; Female; Ge	1982
[Modern treatment of bone infection. Papineau's method and implantation of gentamicin-containing cement pellets]. Chirurgie; memoires de l'Academie de chirurgie, 1982, Volume: 108, Issue:6 Topics: Bone Cements; Drainage; Gentamicins; Humans; Osteitis; Therapeutic Irrigation	1982
[Chronic and insidious infections]. Hefte zur Unfallheilkunde, 1982, Volume: 157 Topics: Adult; Bone and Bones; Chronic Disease; Follow-Up Studies; Fracture Fixation, Internal; Fractures, C	1982
[In vitro evaluation of antibiotic diffusion from antibiotic impregnated xenografts]. Revue de chirurgie orthopedique et reparatrice de l'appareil moteur, 1996, Volume: 82, Issue:1 Topics: Anti-Bacterial Agents; Ciprofloxacin; Diffusion; Drug Delivery Systems; Gentamicins; Humans; In Vitr	1996
Treatment of bacterial tarsal tenosynovitis and osteitis of the sustentaculum tali of the calcaneus in five horses. Equine veterinary journal, 1997, Volume: 29, Issue:3 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Calcaneus; Enterobacter; Escherichia coli; Gen	1997
[Intracranial and cranial complications of paranasal sinusitis. Report of 4 cases at the Lomé University Hospital Center]. Dakar medical, 1995, Volume: 40, Issue:2 Topics: Abscess; Adolescent; Ampicillin; Child; Combined Modality Therapy; Cutaneous Fistula; Drainage; Drug	1995
[Local infection treatment in accident surgery. C. Gentamycin-containing PMMA-spheres and chains. Experimental principles for the application of antibiotic-containing polymethylmethacrylate]. Aktuelle Probleme in Chirurgie und Orthopadie, 1979, Issue:12 Topics: Animals; Anti-Bacterial Agents; Bone Cements; Delayed-Action Preparations; Dogs; Gentamicins; Humans	1979
[The treatment of infected osteosynthesis using gentamycin - PMMA - bead chains]. Hefte zur Unfallheilkunde, 1979, Volume: 138 Topics: Acrylic Resins; Adult; Fracture Fixation, Internal; Gentamicins; Humans; Male; Osteitis; Pharmaceuti	1979
[Treatment of chronic osteitis with gentamicin balls]. Polski przeglad chirurgiczny, 1978, Volume: 50, Issue:8 Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Gentamicins; Humans; Methods; Middle Aged; Osteitis	1978
[Cephalosporin antibiotics from the firm Glaxo in treatment of patients with complications after trauma]. Polimery w medycynie, 1992, Volume: 22, Issue:3 Topics: Anti-Infective Agents, Local; Cephalosporins; Fractures, Bone; Fractures, Open; Gentamicins; Humans;	1992
[Septopal from E. Merck in the prevention and treatment of bone and soft tissue infections]. Polimery w medycynie, 1992, Volume: 22, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bacterial Infections; Child; Child, Preschool; Chronic D	1992
[Radiologic evaluation of changes occurring in bone under the influence of gentamycin-septopal]. Polimery w medycynie, 1992, Volume: 22, Issue:3 Topics: Adult; Bone and Bones; Chronic Disease; Drug Implants; Gentamicins; Humans; Male; Methylmethacrylate	1992
[Effect of septopal on kidney function during treatment of traumatic chronic inflammation of bones]. Polimery w medycynie, 1992, Volume: 22, Issue:3 Topics: Chronic Disease; Creatinine; Fractures, Bone; Gentamicins; Humans; Kidney; Kidney Function Tests; Me	1992
[Use of septopal in treatment of acute blood-borne inflammation of bones in children]. Polimery w medycynie, 1992, Volume: 22, Issue:3 Topics: Acute Disease; Child; Child, Preschool; Drug Implants; Gentamicins; Hematologic Diseases; Humans; In	1992
[Bioresorbable collagen-gentamicin compound as local antibiotic therapy]. Aktuelle Probleme in Chirurgie und Orthopadie, 1990, Volume: 34 Topics: Anti-Infective Agents, Local; Collagen; Combined Modality Therapy; Debridement; Female; Follow-Up St	1990
[Infection of bones and joints]. Aktuelle Probleme in Chirurgie und Orthopadie, 1989, Volume: 34 Topics: Anti-Infective Agents; Arthritis, Infectious; Bone Transplantation; Combined Modality Therapy; Drain	1989
[Medium term results of treatment of post-traumatic osteitis and osteomyelitis with gentamycin-PMMA minichains]. Aktuelle Traumatologie, 1986, Volume: 16, Issue:4 Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Female; Follow-Up Studies; Fracture Fixation, In	1986
[Clinical experiences with long-term implantation of bone cement beads containing antibiotics in bone infections]. Aktuelle Probleme in Chirurgie und Orthopadie, 1987, Volume: 31 Topics: Adult; Aged; Female; Gentamicins; Humans; Long-Term Care; Male; Methylmethacrylates; Middle Aged; Os	1987
[Use and experiences with gentamycin-PMMA chains in 500 cases of osteitis over a 7-year period]. Aktuelle Probleme in Chirurgie und Orthopadie, 1987, Volume: 31 Topics: Follow-Up Studies; Gentamicins; Humans; Methylmethacrylates; Osteitis	1987
[Local antibiotic therapy in postoperative and post-traumatic osteitis with the Septopal chain]. Der Unfallchirurg, 1988, Volume: 91, Issue:9 Topics: Femoral Fractures; Fracture Fixation, Internal; Gentamicins; Humans; Methylmethacrylates; Osteitis;	1988
Reimplantation in infection. Elution of gentamicin from cement and beads. Clinical orthopaedics and related research, 1986, Issue:207 Topics: Bone Cements; Drug Resistance, Microbial; Gentamicins; Hip Prosthesis; Humans; Methylmethacrylate; M	1986
Clinical experience with gentamicin in neonates. Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology, 1973 Topics: Drug Therapy, Combination; Enteritis; Enterobacteriaceae; Enterobacteriaceae Infections; Epididymiti	1973
[Clinical study of gentamicin (ampules of 2 ml with measured dose of 80 mg)]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1971, Volume: 16, Issue:10 Topics: Adult; Aged; Bacterial Infections; Female; Gentamicins; Humans; Male; Meningitis; Middle Aged; Ostei	1971

gentamicin and Bone Inflammation