gentamicin has been researched along with Body Weight in 216 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Extended-interval dosing of gentamicin has several advantages over conventional multiple-daily dosing for the treatment of sepsis." | 9.14 | Simplified dosing of gentamicin for treatment of sepsis in Bangladeshi neonates. ( Aranda, J; Chowdhury, NA; Coffey, P; Darmstadt, GL; Edwards, D; Hossain, MM; Miller-Bell, M; Saha, SK; Shirin, M, 2009) |
| "The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appendicitis patients." | 9.11 | The influence of weight with assay error on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients. ( Burm, JP, 2005) |
| "The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis." | 9.10 | Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours. ( Haddad, B; Leidwanger, C; Livingston, JC; Llata, E; Mabie, B; Rinehart, E; Sibai, B, 2003) |
| "A pharmacokinetic approach was used for gentamicin dosing in 19 children and young adults with cystic fibrosis." | 9.05 | Dosing implications of altered gentamicin disposition in patients with cystic fibrosis. ( Hilman, BC; Kearns, GL; Wilson, JT, 1982) |
| "To identify and characterize rates of acute kidney injury (AKI) in urologic prosthetic surgery, both before and after the implementation of weight-based gentamicin dosing." | 7.91 | Potential Association of Weight-Based Gentamicin with Increased Acute Kidney Injury in Urologic Prosthetic Surgery. ( Anele, UA; Klausner, AP; Krzastek, SC; Moore, RH; Roseman, JT, 2019) |
| "To evaluate an existing once-daily gentamicin dosing guideline in children with febrile neutropenia resulting from antineoplastic therapy and, if necessary, to develop a new simulated dosing guideline that would achieve pharmacokinetic targets more reliably after the first dose." | 7.76 | Once-daily gentamicin dosing in children with febrile neutropenia resulting from antineoplastic therapy. ( Atenafu, EG; Boodhan, S; Dupuis, LL; Inparajah, M; Naqvi, A; Sibbald, C; Wong, C, 2010) |
| "The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appendicitis patients." | 7.73 | The influence of assay error weight on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients. ( Burm, JP, 2005) |
| " The objective of this study was to evaluate the efficacy of a new biodegradable, gentamicin-loaded poly(D,L-lactide) (PDLLA) coating of orthopedic devices in preventing implant-related osteomyelitis." | 7.72 | Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats. ( Haas, NP; Lucke, M; Raschke, M; Sadoni, S; Schiller, R; Schmidmaier, G; Wildemann, B, 2003) |
| " We obtained serum gentamicin peak and trough levels in 23 pregnant women with pyelonephritis." | 7.69 | Gentamicin levels in pregnant women with pyelonephritis. ( Blanco, JD; Graham, JM; Magee, KP; Oshiro, BT, 1994) |
| "The pharmacokinetic parameters of gentamicin and tobramycin were evaluated and compared for 260 patients with pleural effusions and 1,049 patients without pleural effusions by chest radiograph." | 7.68 | Variation in the pharmacokinetics of gentamicin and tobramycin in patients with pleural effusions and hypoalbuminemia. ( Bertino, JS; Etzel, JV; Nafziger, AN, 1992) |
| "Gentamicin volume of distribution (V) was related to body weight (W) in 183 obese, normal weight and infant patients as reported in five published studies." | 7.67 | Gentamicin volume of distribution as a power function of body weight. ( Keller, F, 1989) |
| " >24 hours) dosing may be applicable to neonates." | 6.44 | Extended-interval dosing of gentamicin for treatment of neonatal sepsis in developed and developing countries. ( Batra, M; Darmstadt, GL; Law, K; Law, P; Miller-Bell, M, 2008) |
| "Based on the study, we propose specific mg/kg dose reductions with decreasing CKD-EPI values for the obese population, and extension of the dosing interval beyond 24 h when CKD-EPI drops below 50 mL/min/1." | 5.56 | Dose recommendations for gentamicin in the real-world obese population with varying body weight and renal (dys)function. ( Becker, ML; Brüggemann, RJM; Knibbe, CAJ; Smit, C; van Dongen, EPA; van Schip, AM, 2020) |
| "Extended-interval dosing of gentamicin has several advantages over conventional multiple-daily dosing for the treatment of sepsis." | 5.14 | Simplified dosing of gentamicin for treatment of sepsis in Bangladeshi neonates. ( Aranda, J; Chowdhury, NA; Coffey, P; Darmstadt, GL; Edwards, D; Hossain, MM; Miller-Bell, M; Saha, SK; Shirin, M, 2009) |
| "The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appendicitis patients." | 5.11 | The influence of weight with assay error on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients. ( Burm, JP, 2005) |
| "The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis." | 5.10 | Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours. ( Haddad, B; Leidwanger, C; Livingston, JC; Llata, E; Mabie, B; Rinehart, E; Sibai, B, 2003) |
| "A pharmacokinetic approach was used for gentamicin dosing in 19 children and young adults with cystic fibrosis." | 5.05 | Dosing implications of altered gentamicin disposition in patients with cystic fibrosis. ( Hilman, BC; Kearns, GL; Wilson, JT, 1982) |
| " The degree of hepatoprotection was measured by assessment of body weight, liver weight, absolute liver weight and estimations of plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct bilirubin, tissue malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activities." | 4.31 | Salicylic acid protects gentamicin-induced hepatotoxicity: Study in rabbits. ( Gulnaz, -; Sheikh Muhammad Usman, -; Syeda Nuzhat Fatima Zaidi, -, 2023) |
| "Gentamicin nephrotoxicity was characterized by a significant rise in serum urea and creatinine levels and a significant reduction in body weight and an increase in kidney weight/body weight." | 4.12 | Protective Effect of Curcumin Against Gentamicin-induced Nephrotoxicity Mediated by p38 MAPK, Nuclear Factor- Kappa B, Nuclear Factor Erythroid 2-Related Factor 2. ( Uz, YH; Uzun-Goren, D, 2022) |
| " Biochemical evaluation was carried out by assessment of body weights and by estimating renal function tests (plasma urea, plasma creatinine and plasma uric acid), tissue antioxidant enzymes (catalase, SOD) and MDA level." | 4.02 | Protective role of salicylic acid in gentamicin induced nephrotoxicity. ( Fatimah, SN; Usman, SM, 2021) |
| "To identify and characterize rates of acute kidney injury (AKI) in urologic prosthetic surgery, both before and after the implementation of weight-based gentamicin dosing." | 3.91 | Potential Association of Weight-Based Gentamicin with Increased Acute Kidney Injury in Urologic Prosthetic Surgery. ( Anele, UA; Klausner, AP; Krzastek, SC; Moore, RH; Roseman, JT, 2019) |
| " Potassium dichromate and gentamicin nephrotoxicity assessed in terms of body weight, kidney weight, creatinine, urea, uric acid, BUN, albumin and total protein." | 3.88 | Potential action of Rumex vesicarius (L.) against potassium dichromate and gentamicin induced nephrotoxicity in experimental rats. ( Bag, A; Chandiran, S; Manavalan, G; Shaik, S; Subramaniyan, V, 2018) |
| "Based on the use of gentamicin as a surrogate guide for renally adjusted drugs, these results support dosing interval selection based on a normalized body weight method and a formula reagent adjustment factor of 90% within the Cockcroft-Gault formula." | 3.85 | No role for patient body weight on renal function assessment for drug dosing. ( Ariano, RE; Davis, JC; Poncsak, KR; Vercaigne, LM; Zelenitsky, SA, 2017) |
| "Extended-interval dosing (EID) regimens of gentamicin have been validated for treating confirmed or suspected early- and late-onset sepsis in preterm infants in the first week of life." | 3.85 | Extended-interval Dosing of Gentamicin in Premature Neonates Born at <32 Weeks' Gestation and >7 Days of age. ( Akierman, AR; Alshaikh, B; Dersch-Mills, D; Dobry, J; Sundaram, A; Yusuf, K, 2017) |
| " Body weight, daily fluid and feed intakes, and serum levels of creatinine, urea, and electrolytes were monitored on a weekly basis, and renal histology was evaluated at the end of the study." | 3.80 | Costus afer ker gawl leaves against gentamicin-induced nephrotoxicity in rats. ( Ezejiofor, AN; Orisakwe, OE; Orish, CN, 2014) |
| "To evaluate an existing once-daily gentamicin dosing guideline in children with febrile neutropenia resulting from antineoplastic therapy and, if necessary, to develop a new simulated dosing guideline that would achieve pharmacokinetic targets more reliably after the first dose." | 3.76 | Once-daily gentamicin dosing in children with febrile neutropenia resulting from antineoplastic therapy. ( Atenafu, EG; Boodhan, S; Dupuis, LL; Inparajah, M; Naqvi, A; Sibbald, C; Wong, C, 2010) |
| "The pharmacokinetics and bioavailability of gentamicin sulphate (5 mg/kg body weight) were studied in 50 female broiler chickens after single intravenous (i." | 3.74 | Comparative pharmacokinetics of gentamicin after intravenous, intramuscular, subcutaneous and oral administration in broiler chickens. ( Abu-Basha, EA; Al-Shunnaq, AF; Idkaidek, NM, 2007) |
| "The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appendicitis patients." | 3.73 | The influence of assay error weight on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients. ( Burm, JP, 2005) |
| " The objective of this study was to evaluate the efficacy of a new biodegradable, gentamicin-loaded poly(D,L-lactide) (PDLLA) coating of orthopedic devices in preventing implant-related osteomyelitis." | 3.72 | Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats. ( Haas, NP; Lucke, M; Raschke, M; Sadoni, S; Schiller, R; Schmidmaier, G; Wildemann, B, 2003) |
| " In rats treated with gentamicin (70 mg/Kg body weight, subcutaneously, every 12 h, for 4 days), renal oxidative stress was made evident by the increase in protein carbonyl content and 4-hydroxy-2-nonenal, and the nitrosative stress was made evident by the increase in 3-nitrotyrosine." | 3.72 | S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. ( Barrera, D; Castro, L; Chirino, YI; Hernández-Pando, R; Macías-Ruvalcaba, NA; Maldonado, PD; Medina-Campos, ON; Pedraza-Chaverrí, J; Salcedo, MI, 2004) |
| " We obtained serum gentamicin peak and trough levels in 23 pregnant women with pyelonephritis." | 3.69 | Gentamicin levels in pregnant women with pyelonephritis. ( Blanco, JD; Graham, JM; Magee, KP; Oshiro, BT, 1994) |
| " Gentamicin in combination with 20 mg ethacrynic acid/kg body weight produced a hearing loss of 95 dB in animals on a low protein diet and 12 dB in animals on a full protein diet." | 3.69 | [Reduced nutritional status enhances ototoxicity]. ( Lautermann, J; Schacht, J, 1995) |
| "Clinicopathologic and renal histopathologic changes induced by gentamicin (10 mg/kg of body weight, IM, q 8 h, for 8 days) were compared in dogs fed an n-3 fatty acid-supplemented diet containing a fatty acid ratio of 5." | 3.69 | Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs. ( Behrend, EN; Fettman, MJ; Getzy, DM; Grauer, GF; Greco, DS; Mani, I; Reinhart, GA, 1996) |
| "The pharmacokinetic parameters of gentamicin and tobramycin were evaluated and compared for 260 patients with pleural effusions and 1,049 patients without pleural effusions by chest radiograph." | 3.68 | Variation in the pharmacokinetics of gentamicin and tobramycin in patients with pleural effusions and hypoalbuminemia. ( Bertino, JS; Etzel, JV; Nafziger, AN, 1992) |
| "Gentamicin intrapatient pharmacokinetics variations were studied in 40 critically ill medical patients, suffering gram-negative sepsis." | 3.68 | Gentamicin volume of distribution in critically ill septic patients. ( Benito, S; Fernández, R; Izquierdo, I; Net, A; Rello, J; Torrent, J; Triginer, C, 1990) |
| "Visceral protein, body weight, and body composition were assessed in patients receiving gentamicin to determine whether a meaningful analysis of nutritional status can be used to identify patients with an expanded gentamicin volume of distribution (V)." | 3.68 | Expanded gentamicin volume of distribution in patients with indicators of malnutrition. ( Pilla, AM; Popovich, J; Zarowitz, BJ, 1990) |
| "Gentamicin volume of distribution (V) was related to body weight (W) in 183 obese, normal weight and infant patients as reported in five published studies." | 3.67 | Gentamicin volume of distribution as a power function of body weight. ( Keller, F, 1989) |
| "Eleven premature neonates received gentamicin sulfate for treatment of suspected gram-negative sepsis with accompanying respiratory distress syndrome." | 3.66 | Two-compartment gentamicin pharmacokinetics in premature neonates: a comparison to adults with decreased glomerular filtration rates. ( Grassi, A; Haughey, DB; Hilligoss, DM; Schentag, JJ, 1980) |
| "Gentamicin pharmacokinetics were studied in eight patients with ascites." | 3.66 | Altered gentamicin distribution in ascitic patients. ( Gill, MA; Kern, JW, 1979) |
| "Gentamicin is an aminoglycoside antibiotic with a small therapeutic window that is currently used primarily as part of short-term empirical combination therapy." | 2.82 | Clinical Pharmacokinetics of Gentamicin in Various Patient Populations and Consequences for Optimal Dosing for Gram-Negative Infections: An Updated Review. ( de Vroom, SL; Hodiamont, CJ; Mathôt, RAA; Prins, JM; van den Broek, AK; van Hest, RM, 2022) |
| "Preterm and term newborn infants show wide interindividual variability (IIV) in pharmacokinetic parameters of gentamicin." | 2.74 | Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study. ( Ewald, U; Friberg, LE; Honoré, PH; Nielsen, EI; Sandström, M, 2009) |
| "Amoxicillin plasma concentrations, pharmacokinetic parameters, and the influence of demographic, anthropometric, and clinical covariates were investigated in 150 neonates." | 2.72 | Population pharmacokinetics and dosing of amoxicillin in (pre)term neonates. ( Degraeuwe, PL; Nieman, FH; Pullen, J; Stolk, LM; van Tiel, FH; Zimmermann, LJ, 2006) |
| " Mean (95% confidence interval) values of CL and half-life were 0." | 2.71 | Population pharmacokinetics of gentamicin in South African newborns. ( Adhikari, M; Botha, JH; du Preez, MJ, 2003) |
| " Once daily dosage can achieve the equivalent efficacy compared to a twice-daily dosage regimen." | 2.70 | Gentamicin in neonatal infection: once versus twice daily dosage. ( Ayudhya, DP; Chotigeat, U; Narongsanti, A, 2001) |
| " >24 hours) dosing may be applicable to neonates." | 2.44 | Extended-interval dosing of gentamicin for treatment of neonatal sepsis in developed and developing countries. ( Batra, M; Darmstadt, GL; Law, K; Law, P; Miller-Bell, M, 2008) |
| "3 mg/kg (mean +/- SD) twice daily, a dosage that was not changed during the follow-up period." | 2.38 | Time course of trough serum gentamicin concentrations in preterm and term neonates. ( Armijo, JA; de Cos, MA; Gómez, F; Gómez-Ullate, J, 1992) |
| " The volume of the ECF, therefore, affects the magnitude of Cmax when a constant dose is administered." | 2.36 | Antibiotic pharmacokinetics in newborns. ( Smith, AL, 1982) |
| "This retrospective review and simulation compared target attainment among 4 arms: historical dosing according to SOC, via nomogram for initial dosing (SOC-initial) and via clinician judgment in response to measured concentrations (SOC-adjusted), and simulated dosing using the CDSS, incorporating a neonatal pharmacokinetic model for initial dosing (CDSS-initial) and incorporating maximum a posteriori-Bayesian analysis in response to measured concentrations (CDSS-adjusted)." | 1.56 | Simulated Comparison of a Bayesian Clinical Decision Support System Versus Standard of Care For Achieving Gentamicin Pharmacokinetic Targets in Neonates. ( Faldasz, JD; Myers, SR; Yu, CZ, 2020) |
| "Based on the study, we propose specific mg/kg dose reductions with decreasing CKD-EPI values for the obese population, and extension of the dosing interval beyond 24 h when CKD-EPI drops below 50 mL/min/1." | 1.56 | Dose recommendations for gentamicin in the real-world obese population with varying body weight and renal (dys)function. ( Becker, ML; Brüggemann, RJM; Knibbe, CAJ; Smit, C; van Dongen, EPA; van Schip, AM, 2020) |
| " We developed a population pharmacokinetic/pharmacodynamic model to optimize gentamicin dosing in pediatrics." | 1.51 | Optimizing Gentamicin Dosing in Pediatrics Using Monte Carlo Simulations. ( Abouelkheir, M; Algahtani, S; Alkoraishi, A; Alsultan, A; Elsharawy, Y; Mansy, W; Neely, MN; Osman, R, 2019) |
| " These results will be used to inform individualized initial dosing strategies and serve as a prior PK model for Bayesian updating and forecasting as individual clinical observations become available." | 1.51 | Population Pharmacokinetic Modeling of Gentamicin in Pediatrics. ( Gobburu, JVS; Ivaturi, V; Sherwin, C; Wang, H, 2019) |
| "On postnatal day (PND) 2, Wistar rats were cross-fostered into normal sized litters (12 pups) or large litters (20 pups) to create normal food (NF) or food restricted (FR) litters to simulate growth restriction and dosed daily intraperitoneally with placebo, 4 mg/kg of gentamicin or 50 mg/kg ceftazidime until PND 8." | 1.46 | Early postnatal gentamicin and ceftazidime treatment in normal and food restricted neonatal wistar rats: Implications for kidney development. ( Brüggemann, RJM; Bueters, RRG; Jeronimus-Klaasen, A; Schreuder, MF; van den Heuvel, LP, 2017) |
| "13230 AIM: When different models for weight and age are used in paediatric pharmacokinetic studies it is difficult to compare parameters between studies or perform model-based meta-analyses." | 1.46 | Scaling clearance in paediatric pharmacokinetics: All models are wrong, which are useful? ( Barker, CI; Germovsek, E; Sharland, M; Standing, JF, 2017) |
| " On the basis of clinical presentation and diagnosis, a once-daily dosage regimen of 7 mg/kg of body weight every 24 h is proposed for intravenous gentamicin, followed by therapeutic drug monitoring in order to avoid toxicity and ensure efficacy with minimal blood sampling." | 1.42 | Population pharmacokinetics of gentamicin and dosing optimization for infants. ( Barcia, E; García, B; Medellín-Garibay, SE; Peña-Cabia, S; Romano-Moreno, S; Rueda-Naharro, A, 2015) |
| "To determine dose and eligibility criteria for once-daily dosing (ODD) of gentamicin in critically ill pediatric patients." | 1.40 | Dose derivation of once-daily dosing guidelines for gentamicin in critically ill pediatric patients. ( Atenafu, EG; Bitnun, SA; Cox, P; Papaioannou, V; Parshuram, C; Pong, S; Richardson, S; Schwartz, S; Seto, W; Trope, A; Zakova, M, 2014) |
| "In the pharmacokinetic analysis (NONMEM VI) based on data of gentamicin, tobramycin and vancomycin collected in 1,760 patients (age 1 day-18 years, bodyweight 415 g-85 kg), a distinction was made between drug-specific and system-specific information." | 1.40 | Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration. ( Allegaert, K; Brussee, JM; Danhof, M; De Cock, RF; de Hoog, M; Knibbe, CA; Mulla, H; Sherwin, CM; van den Anker, JN, 2014) |
| "This observational study conducted in a large cohort of newborns confirms the importance of body weight and gestational age for dosage adjustment." | 1.40 | Population pharmacokinetic study of gentamicin in a large cohort of premature and term neonates. ( Buclin, T; Csajka, C; Fuchs, A; Giannoni, E; Guidi, M; Werner, D; Widmer, N, 2014) |
| "Gentamicin was given to rats intraperitoneally once every day starting on day 0." | 1.40 | Urinary excretion pattern of exosomal aquaporin-2 in rats that received gentamicin. ( Abdeen, A; El-Shawarby, R; Ikeda, M; Sonoda, H; Takahashi, S, 2014) |
| "Aminoglycoside concentration-time data and relevant clinical characteristics were collated from clinical pharmacokinetic databases established in Glasgow, Scotland and The Hague, The Netherlands." | 1.39 | Influence of multiple courses of therapy on aminoglycoside clearance in adult patients with cystic fibrosis. ( Alghanem, S; Paterson, I; Thomson, AH; Touw, DJ, 2013) |
| "Gentamicin is a widely used antibiotic in the intensive care unit (ICU)." | 1.39 | Gentamicin in hemodialyzed critical care patients: early dialysis after administration of a high dose should be considered. ( Badin, J; Dupuis, A; Pinsard, M; Robert, R; Veinstein, A; Venisse, N, 2013) |
| " In all evaluated cases, gentamicin was administered according to a standardized dosing protocol based on gestational age and weight." | 1.38 | Development of criteria for gentamicin monitoring in a neonatal intensive care unit. ( Pallotto, E; Sandritter, TL; Stach, LM, 2012) |
| "Gentamicin clearance was significantly lower in frail participants (46." | 1.37 | Gentamicin pharmacokinetics in old age and frailty. ( Carroll, PR; Gnjidic, D; Hilmer, SN; Matthews, S; Mitchell, SJ; Rubie, P; Tran, K; Wright, J, 2011) |
| " Currently, no literature describes the appropriate dosing of aminoglycoside antibiotics for infants and children with congenital heart disease." | 1.36 | Gentamicin dosing for pediatric patients with congenital heart disease. ( Bork, SJ; Moffett, BS; Mott, AR, 2010) |
| " It was found to be a safe alternative for various severe infections." | 1.36 | Sub-acute toxicity study of a new aminoglycoside etimicin sulphate in swiss albino mice. ( Chaudhary, M; Dwivedi, VK; Gupta, A; Payasi, A, 2010) |
| "Gentamicin (GM) is an aminoglycoside antibiotic commonly used against life threatening gram negative bacterial infections, however, nephrotoxicity remains the major concern for its long term use." | 1.34 | Time dependent effect of gentamicin on enzymes of carbohydrate metabolism and terminal digestion in rat intestine. ( Farooq, N; Khan, F; Priyamvada, S; Yusufi, AN, 2007) |
| "To determine the pharmacokinetic parameters of gentamicin in a population of 200 premature newborns and to investigate the influence of several clinical and physiopathological covariates on the pharmacokinetics of the drug." | 1.33 | Population pharmacokinetics of gentamicin in premature newborns. ( Barcia, E; García, B; Molina, IT; Pérez, F, 2006) |
| "Gentamicin (GM) is an antibiotic whose clinical use is limited by its nephrotoxicity." | 1.32 | Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats. ( Barrera, D; Hernández-Pando, R; Ibarra-Rubio, ME; Maldonado, PD; Medina-Campos, ON; Pedraza-Chaverrí, J, 2003) |
| "Gentamicin (GM) is an antibiotic whose clinical use is limited by its nephrotoxicity." | 1.32 | Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats. ( Barrera, D; Cerón, A; Hernández-Pando, R; Maldonado, PD; Medina-Campos, ON; Pedraza-Chaverrí, J, 2003) |
| "A two compartment pharmacokinetic model best described the aminoglycoside data." | 1.32 | Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides. ( Holford, N; Kirkpatrick, C; Matthews, I, 2004) |
| "Population pharmacokinetic parameter estimates were calculated from 725 routine plasma gentamicin concentrations obtained in 177 neonates of 24 to 42 weeks' gestational age in their first week of life." | 1.31 | Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates. ( de Boer, A; de Wolf, MC; Degraeuwe, PL; Nieman, FH; Stolk, LM, 2002) |
| "Although it is well known that ethacrynic acid (EA) can enhance gentamicin (GM) ototoxicity, there has been no systematic study of the relationship between dosing parameters and inner ear pathology." | 1.31 | Chinchilla models of selective cochlear hair cell loss. ( Ding, D; Jiang, H; McFadden, SL; Salvi, RJ; Woo, JM, 2002) |
| " However, the pharmacokinetic parameters are variable in these patients." | 1.31 | Population pharmacokinetics of aminoglycosides in critically ill trauma patients on once-daily regimens. ( Barletta, JF; Erstad, BL; Johnson, SB; Nix, DE; Nix, LC, 2000) |
| "Gentamicin (3 mg/kg, iv) was administered 24 hours after an endotoxin challenge (5 mg/kg, ip)." | 1.30 | Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats. ( Ali, BH; Bashir, AK; Tanira, MO, 1997) |
| "The objective of this study was to confirm the variation of the pharmacokinetic parameters of gentamicin in neonates and to establish guidelines for a dosage regimen." | 1.30 | [Monitoring of gentamycin serum concentration in neonates. Usefulness in adjustment of dosage]. ( García-Delgado, R; Marco-Macián, A; Sánchez-Romero, A; Tébar-Gil, R, 1997) |
| "The gentamicin group was treated with one dose of gentamicin, 75 mg/Kg i." | 1.30 | Synergestic effects of noise and aminoglycoside antibiotic (gentamicin) on auditory function in the gerbil. ( Chen, SS; Chen, TJ; Hsieh, YL; Lin, CH, 1997) |
| " This study supports the idea that iron and free radicals play a critical role in the toxic side effects of aminoglycoside antibiotics." | 1.30 | Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity. ( Schacht, J; Sha, SH; Song, BB, 1998) |
| " Demographic and pharmacokinetic data on 202 neonates treated with gentamicin at a 500-bed medical center were collected over a three-year period." | 1.30 | Evaluation of gentamicin pharmacokinetics and dosing protocols in 195 neonates. ( Austin, ML; Frye, RF; Murphy, JE, 1998) |
| "To develop and validate a population pharmacokinetic model for gentamicin in horses, using retrospective clinical data." | 1.30 | Population pharmacokinetics of gentamicin in horses. ( Martín-Jiménez, T; Papich, MG; Riviere, JE, 1998) |
| "2." | 1.29 | Plasma lipid profile in rats with gentamicin-induced nephrotoxicity. ( Abdel-Gayoum, AA; Ali, BH; Bashir, AA; Ghawarsha, K, 1993) |
| "The Cockcroft-Gault and Salazar-Corcoran equations were compared with respect to prediction of gentamicin pharmacokinetic values in obese and nonobese patients, and the results were used to formulate guidelines for calculating initial gentamicin dosages in obese patients." | 1.29 | Creatinine-clearance estimates for predicting gentamicin pharmacokinetic values in obese patients. ( Chandler, MH; Leader, WG; Tsubaki, T, 1994) |
| " CLcr was estimated by the modified equation (which normalized body weight to 72 kg) and by the standard equation using ABW, IBW, and dosing body weight (DBW)." | 1.29 | Comparison of creatinine clearance estimation methods in patients with trauma. ( Chandler, MH; Davis, GA, 1996) |
| "Gentamicin was measured in serum and in urine by a fluorescence polarization immunoassay." | 1.29 | Gentamicin pharmacokinetics in newborn and 42-day-old male piglets. ( Giroux, D; Martineau, GP; Sirois, G, 1995) |
| "The objectives of this study were to determine if a standardized gentamicin dosing protocol would improve clinical effectiveness, yield higher peak serum concentrations, and improve the success rate of attaining peaks in the desired range when compared with empiric dosing practices used by prescribers." | 1.29 | Standardized gentamicin dosing enhances peak serum concentrations. ( Austin, TW; Bombassaro, AM; Chase, H; Doig, GS; Girotti, MJ; Sharad, S, 1996) |
| "In verapamil-treated rats (5 mg/kg/day), no histological or biochemical evidence of renal injury was detected." | 1.28 | Verapamil increases the nephrotoxic potential of gentamicin in rats. ( Fadali, GA; Farag, MM; Kandil, M, 1992) |
| " The results illustrate the value of interspecies comparisons of pharmacokinetic data for estimating appropriate dosage regimes for vertebrates for which no specific data are available." | 1.28 | Variation in plasma halflife of gentamicin between species in relation to bodyweight and taxonomy. ( Kirkwood, JK; Merriam, J, 1990) |
| " We sought to determine the degree of absorption and risk of either inadequate or toxic blood levels that might follow gentamicin absorption." | 1.28 | Gentamicin solution for mediastinal irrigation: systemic absorption, bactericidal activity, and toxicity. ( Finlayson, DC; Hall, RI; Jones, EL; Kopel, ME; Lampasona, V; Mullins, R; Riemersma, L; Tobia, V, 1989) |
| " There was no adverse effect on fertility ability at any dose." | 1.27 | [Safety evaluation of micronomicin VII. Fertility study by intravenous injection in rats]. ( Deguchi, T; Fujita, T; Hara, T; Takahashi, H, 1983) |
| " There was no adverse effect on new borns at any dose." | 1.27 | [Safety evaluation of micronomicin VIII. Teratogenicity studies in rabbits after intravenous injection]. ( Deguchi, T; Fujita, T; Hara, T; Takahashi, H, 1983) |
| " There was no adverse effect on delivery and nursing ability in dams at any dose." | 1.27 | [Safety evaluation of micronomicin IX. Perinatal and postnatal study by intravenous injection in rats]. ( Deguchi, T; Fujita, T; Hara, T; Takahashi, H, 1983) |
| " There was no adverse effect on new borns at any dose." | 1.27 | [Safety evaluation of micronomicin. III. Teratogenicity studies in rats]. ( Hara, T; Miyazaki, H; Nishikawa, S; Ohguro, Y, 1983) |
| "The plasma peak, trough, and peak-trough concentrations of netilmicin given to preterm and term infants were measured after different regimens to determine which dosage would provide satisfactory peak and trough concentrations." | 1.27 | Clinical pharmacology of netilmicin in the newborn. ( Milner, RD; Phillips, AM, 1983) |
| "Human acute renal failure is accompanied by an increase in parathyroid hormone (PTH), a hormone that stimulates calcium uptake by tissues, and by a decrease in thyroid hormone, a hormone that increases renal cortex Na-K-ATPase activity." | 1.27 | Protective effect of thyroxine but not parathyroidectomy on gentamicin nephrotoxicity. ( Cronin, RE; Newman, JA, 1985) |
| " Treatment groups consisting of 8 male rats of each strain and four male guinea pigs were dosed subcutaneously for 14 days with either 80 or 100 mg/kg of gentamicin sulfate in saline." | 1.27 | Comparative ototoxicity of gentamicin in the guinea pig and two strains of rats. ( Conolly, RB; Rarey, KE; Sullivan, MJ, 1987) |
| " Combination with ASA potentiated the toxic effect of the aminoglycoside after 10 but not after 5 days of treatment." | 1.27 | Prostaglandins and aminoglycoside nephrotoxicity. ( Assael, BM; Bamonte, F; Chiabrando, C; Gagliardi, L; Noseda, A; Salmona, M, 1985) |
| " Expressed as a percentage of the injected amount, the uptake decreased as the aminoglycoside dosage increased." | 1.27 | Nephrotoxicity of aminoglycosides in young and adult rats. ( Adejuyigbe, O; Provoost, AP; Wolff, ED, 1985) |
| " The decrease of food intake at the dosage of 50 mg/kg and more, and the resultant depression of maternal body weight gain at the dosage of 100 mg/kg were observed in dams receiving NTL." | 1.26 | [Reproduction study on netilmicin. (1) Teratological study in rats (author's transl)]. ( Furuhashi, T; Komuro, E; Miyoshi, K; Nakayoshi, H; Nomura, A; Uehara, M, 1982) |
| " The serum half-life (t1/2), tended to show higher values in premature than in mature newborns, although this was not statistically significant." | 1.26 | Pharmacokinetic assessment of netilmicin in newborns and older children. ( Bergan, T; Michalsen, H, 1982) |
| " From data recorded on the form, pharmacists calculate ideal body weight, creatinine clearance, predicted rate of elimination, half-life, volume of distribution, serum peak (Cmax) and serum trough (Cmin) concentrations, dosing interval, and maintenance dose." | 1.26 | Aminoglycoside monitoring program. ( Clayman, AE; Miller, PB; Stein, GE; Vakoutis, J, 1981) |
| " Dosage of gentamicin sulfate was 1." | 1.26 | Vestibular toxicity of gentamicin. Incidence in patients receiving long-term hemodialysis therapy. ( Dominguez-Moreno, M; Gailiunas, P; Gottlieb, MN; Lazarus, M; Lowrie, EG; Merrill, JP, 1978) |
| " Dosage was 2-2." | 1.26 | Gentamicin dosage in preterm and term neonates. ( Assael, BM; Gianni, V; Marini, A; Peneff, P; Sereni, F, 1977) |
| "Fifty-seven cancer patients, who had had an 8--15% loss of body weight in the previous 6 months, were studied to establish the reliabity in wasted individuals of presently available nomograms correlating serum creatinine with creatinine clearance." | 1.26 | Nephrotoxic antibiotics in patients with renal failures: guidelines for debilitated patients. ( Carlon, GC; Colaco, FM; Goldiner, PL; Howland, WS; Scheiner, E, 1979) |
| "Recent studies that emphasize the unpredictability of gentamicin serum concentrations have cast doubt on the accuracy of commonly used dosing nomograms." | 1.26 | Gentamicin serum concentrations: pharmacokinetic predictions. ( Hull, JH; Sarubbi, FA, 1976) |
| " Moreover, their combination made it possible to reduce the dosage of the antibiotics and thereby reduce their potential undesirable effect." | 1.25 | An experimental model of Pseudomonas aeruginosa renal infection in rats. ( Hatala, M; Konícková, L; Liska, M; Prát, V; Slugen, I, 1975) |
| " The result or examination of the guinea pigs received BB-K8 at 40 mg/kg and 100 mg/kg respectively for 28 days suggests that BB-K8 at expecting clinical dose, 500 mg per day (for 28 days) may be safe from ototoxicosis in the inner ears." | 1.25 | [Evaluation of ototoxicity of amikacin (BB-K8) by animal test (author's transl)]. ( Akiyoshi, M; Nakada, H; Sato, K; Suzuki, K; Tajima, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 98 (45.37) | 18.7374 |
| 1990's | 40 (18.52) | 18.2507 |
| 2000's | 36 (16.67) | 29.6817 |
| 2010's | 33 (15.28) | 24.3611 |
| 2020's | 9 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Fatimah, SN | 1 |
| Usman, SM | 1 |
| Fatima, SN | 1 |
| Akhtar, S | 1 |
| Shahid, SM | 1 |
| Sajjad, A | 1 |
| Bibi, A | 1 |
| Uzun-Goren, D | 1 |
| Uz, YH | 1 |
| Hodiamont, CJ | 1 |
| van den Broek, AK | 1 |
| de Vroom, SL | 1 |
| Prins, JM | 1 |
| Mathôt, RAA | 1 |
| van Hest, RM | 1 |
| Syeda Nuzhat Fatima Zaidi, - | 1 |
| Gulnaz, - | 1 |
| Sheikh Muhammad Usman, - | 1 |
| Yu, CZ | 1 |
| Myers, SR | 1 |
| Faldasz, JD | 1 |
| Smit, C | 1 |
| van Schip, AM | 1 |
| van Dongen, EPA | 1 |
| Brüggemann, RJM | 2 |
| Becker, ML | 1 |
| Knibbe, CAJ | 1 |
| Sharawy, MH | 1 |
| Serrya, MS | 1 |
| Silva de Almeida, TC | 1 |
| Lanza, K | 1 |
| da Silva Filha, R | 1 |
| C Campos, LMC | 1 |
| Fonseca, EG | 1 |
| Chagas, MW | 1 |
| Rocha, NP | 1 |
| de Sá, MA | 1 |
| Vieira, MAR | 1 |
| Caliari, MV | 1 |
| Kangussu, LM | 1 |
| Ferreira, AJ | 1 |
| Simões E Silva, AC | 1 |
| Ariano, RE | 1 |
| Zelenitsky, SA | 1 |
| Poncsak, KR | 1 |
| Davis, JC | 1 |
| Vercaigne, LM | 1 |
| Sundaram, A | 1 |
| Alshaikh, B | 1 |
| Dersch-Mills, D | 1 |
| Dobry, J | 1 |
| Akierman, AR | 1 |
| Yusuf, K | 1 |
| Bueters, RRG | 1 |
| Jeronimus-Klaasen, A | 1 |
| van den Heuvel, LP | 1 |
| Schreuder, MF | 1 |
| Subramaniyan, V | 1 |
| Shaik, S | 1 |
| Bag, A | 1 |
| Manavalan, G | 1 |
| Chandiran, S | 1 |
| Karaman, M | 1 |
| Budak, H | 1 |
| Çiftci, M | 1 |
| Moore, RH | 1 |
| Anele, UA | 1 |
| Krzastek, SC | 1 |
| Klausner, AP | 1 |
| Roseman, JT | 1 |
| Alsultan, A | 1 |
| Abouelkheir, M | 1 |
| Elsharawy, Y | 1 |
| Alkoraishi, A | 1 |
| Osman, R | 1 |
| Neely, MN | 1 |
| Mansy, W | 1 |
| Algahtani, S | 1 |
| Saleem, M | 1 |
| Javed, F | 1 |
| Asif, M | 1 |
| Baig, MK | 1 |
| Arif, M | 1 |
| Wang, H | 1 |
| Sherwin, C | 1 |
| Gobburu, JVS | 1 |
| Ivaturi, V | 1 |
| Alghanem, S | 1 |
| Paterson, I | 1 |
| Touw, DJ | 1 |
| Thomson, AH | 2 |
| Wang, Z | 1 |
| Shen, L | 1 |
| Li, X | 1 |
| Shu, X | 1 |
| Shan, B | 1 |
| Zhang, L | 1 |
| Gong, Y | 1 |
| Dong, Z | 1 |
| Zakova, M | 1 |
| Pong, S | 1 |
| Trope, A | 1 |
| Atenafu, EG | 2 |
| Papaioannou, V | 1 |
| Bitnun, SA | 1 |
| Richardson, S | 1 |
| Schwartz, S | 1 |
| Cox, P | 1 |
| Parshuram, C | 1 |
| Seto, W | 1 |
| De Cock, RF | 1 |
| Allegaert, K | 1 |
| Brussee, JM | 1 |
| Sherwin, CM | 1 |
| Mulla, H | 1 |
| de Hoog, M | 1 |
| van den Anker, JN | 1 |
| Danhof, M | 1 |
| Knibbe, CA | 1 |
| Fuchs, A | 1 |
| Guidi, M | 1 |
| Giannoni, E | 1 |
| Werner, D | 1 |
| Buclin, T | 1 |
| Widmer, N | 1 |
| Csajka, C | 1 |
| Ezejiofor, AN | 1 |
| Orish, CN | 1 |
| Orisakwe, OE | 1 |
| Ibraheem, ZO | 1 |
| Basir, R | 1 |
| Aljobory, AKh | 1 |
| Ibrahim, OE | 1 |
| Alsumaidaee, A | 1 |
| Yam, MF | 1 |
| Abdeen, A | 1 |
| Sonoda, H | 1 |
| El-Shawarby, R | 1 |
| Takahashi, S | 1 |
| Ikeda, M | 1 |
| Medellín-Garibay, SE | 1 |
| Rueda-Naharro, A | 1 |
| Peña-Cabia, S | 1 |
| García, B | 2 |
| Romano-Moreno, S | 1 |
| Barcia, E | 2 |
| Ullah, N | 1 |
| Khan, MA | 1 |
| Khan, S | 1 |
| Ahmad, H | 1 |
| Asif, AH | 1 |
| Khan, T | 1 |
| Ghaznavi, H | 1 |
| Mehrzadi, S | 1 |
| Dormanesh, B | 1 |
| Tabatabaei, SM | 1 |
| Vahedi, H | 1 |
| Hosseinzadeh, A | 1 |
| Pazoki-Toroudi, H | 1 |
| Rashidian, A | 1 |
| Yang, Y | 1 |
| Ao, HY | 1 |
| Yang, SB | 1 |
| Wang, YG | 1 |
| Lin, WT | 1 |
| Yu, ZF | 1 |
| Tang, TT | 1 |
| Liu, C | 1 |
| Kang, Y | 1 |
| Zhang, H | 1 |
| Zhu, L | 1 |
| Yu, H | 1 |
| Han, C | 1 |
| Germovsek, E | 1 |
| Barker, CI | 1 |
| Sharland, M | 1 |
| Standing, JF | 1 |
| Rashid, U | 1 |
| Khan, MR | 1 |
| Darmstadt, GL | 2 |
| Miller-Bell, M | 2 |
| Batra, M | 1 |
| Law, P | 1 |
| Law, K | 1 |
| De Luca, A | 1 |
| Nico, B | 1 |
| Rolland, JF | 1 |
| Cozzoli, A | 1 |
| Burdi, R | 1 |
| Mangieri, D | 1 |
| Giannuzzi, V | 1 |
| Liantonio, A | 1 |
| Cippone, V | 1 |
| De Bellis, M | 1 |
| Nicchia, GP | 1 |
| Camerino, GM | 1 |
| Frigeri, A | 1 |
| Svelto, M | 1 |
| Camerino, DC | 1 |
| Saleemi, MK | 1 |
| Zargham Khan, M | 1 |
| Javed, I | 1 |
| Khan, A | 1 |
| Ali, BH | 8 |
| Al-Salam, S | 1 |
| Al-Husseini, I | 1 |
| Nemmar, A | 1 |
| Matsumoto, T | 1 |
| Shiva, D | 1 |
| Kawanishi, N | 1 |
| Kato, Y | 1 |
| Woods, JA | 1 |
| Yano, H | 1 |
| Kent, AL | 1 |
| Douglas-Denton, R | 1 |
| Shadbolt, B | 1 |
| Dahlstrom, JE | 1 |
| Maxwell, LE | 1 |
| Koina, ME | 1 |
| Falk, MC | 1 |
| Willenborg, D | 1 |
| Bertram, JF | 1 |
| Nielsen, EI | 1 |
| Sandström, M | 1 |
| Honoré, PH | 1 |
| Ewald, U | 1 |
| Friberg, LE | 1 |
| Roberts, GW | 1 |
| Ibsen, PM | 1 |
| Schiøler, CT | 1 |
| Hossain, MM | 1 |
| Chowdhury, NA | 1 |
| Shirin, M | 1 |
| Saha, SK | 1 |
| Edwards, D | 1 |
| Aranda, J | 1 |
| Coffey, P | 1 |
| Inparajah, M | 1 |
| Wong, C | 1 |
| Sibbald, C | 1 |
| Boodhan, S | 1 |
| Naqvi, A | 1 |
| Dupuis, LL | 1 |
| Moffett, BS | 1 |
| Bork, SJ | 1 |
| Mott, AR | 1 |
| Payasi, A | 1 |
| Chaudhary, M | 1 |
| Gupta, A | 1 |
| Dwivedi, VK | 1 |
| Bottje, W | 1 |
| Wolfenden, A | 1 |
| Ding, L | 1 |
| Wolfenden, R | 1 |
| Morgan, M | 1 |
| Pumford, N | 1 |
| Lassiter, K | 1 |
| Duncan, G | 1 |
| Smith, T | 1 |
| Slagle, T | 1 |
| Hargis, B | 1 |
| Hilmer, SN | 1 |
| Tran, K | 1 |
| Rubie, P | 1 |
| Wright, J | 1 |
| Gnjidic, D | 1 |
| Mitchell, SJ | 1 |
| Matthews, S | 1 |
| Carroll, PR | 1 |
| Muthuraman, A | 1 |
| Singla, SK | 1 |
| Rana, A | 1 |
| Singh, A | 1 |
| Sood, S | 1 |
| Lian, WB | 1 |
| Yeo, CL | 1 |
| Ho, LY | 1 |
| Stach, LM | 1 |
| Pallotto, E | 1 |
| Sandritter, TL | 1 |
| Veinstein, A | 1 |
| Venisse, N | 1 |
| Badin, J | 1 |
| Pinsard, M | 1 |
| Robert, R | 1 |
| Dupuis, A | 1 |
| Stolk, LM | 2 |
| Degraeuwe, PL | 2 |
| Nieman, FH | 2 |
| de Wolf, MC | 1 |
| de Boer, A | 1 |
| Paquette, M | 1 |
| Plante, I | 1 |
| Labrecque, G | 3 |
| Beauchamp, D | 4 |
| Thibault, L | 2 |
| McFadden, SL | 1 |
| Ding, D | 1 |
| Jiang, H | 1 |
| Woo, JM | 1 |
| Salvi, RJ | 1 |
| Livingston, JC | 1 |
| Llata, E | 1 |
| Rinehart, E | 1 |
| Leidwanger, C | 1 |
| Mabie, B | 1 |
| Haddad, B | 1 |
| Sibai, B | 1 |
| Lucke, M | 2 |
| Schmidmaier, G | 2 |
| Sadoni, S | 2 |
| Wildemann, B | 2 |
| Schiller, R | 2 |
| Haas, NP | 2 |
| Raschke, M | 2 |
| Maldonado, PD | 4 |
| Barrera, D | 4 |
| Rivero, I | 1 |
| Mata, R | 1 |
| Medina-Campos, ON | 4 |
| Hernández-Pando, R | 4 |
| Pedraza-Chaverrí, J | 4 |
| Ibarra-Rubio, ME | 1 |
| Botha, JH | 1 |
| du Preez, MJ | 1 |
| Adhikari, M | 1 |
| Cerón, A | 1 |
| Arakawa, M | 1 |
| Shiozuka, M | 1 |
| Nakayama, Y | 1 |
| Hara, T | 11 |
| Hamada, M | 1 |
| Kondo, S | 1 |
| Ikeda, D | 1 |
| Takahashi, Y | 1 |
| Sawa, R | 1 |
| Nonomura, Y | 1 |
| Sheykholeslami, K | 1 |
| Kondo, K | 1 |
| Kaga, K | 1 |
| Kitamura, T | 1 |
| Suzuki-Miyagoe, Y | 1 |
| Takeda, S | 1 |
| Matsuda, R | 1 |
| Chirino, YI | 1 |
| Macías-Ruvalcaba, NA | 1 |
| Castro, L | 1 |
| Salcedo, MI | 1 |
| Matthews, I | 1 |
| Kirkpatrick, C | 1 |
| Holford, N | 1 |
| Al-Qarawi, AA | 1 |
| Mahmoud, OM | 1 |
| Hashad, M | 1 |
| Surke, C | 1 |
| Stemberger, A | 1 |
| Burm, JP | 2 |
| Guo, Y | 1 |
| Xie, C | 1 |
| Rodriguez, RM | 1 |
| Light, RW | 1 |
| Hale, LS | 1 |
| Durham, CR | 1 |
| Pullen, J | 1 |
| van Tiel, FH | 1 |
| Zimmermann, LJ | 1 |
| Pérez, F | 1 |
| Molina, IT | 1 |
| Abu-Basha, EA | 1 |
| Idkaidek, NM | 1 |
| Al-Shunnaq, AF | 1 |
| Farooq, N | 1 |
| Priyamvada, S | 1 |
| Khan, F | 1 |
| Yusufi, AN | 1 |
| Heller, J | 1 |
| Yokota, M | 2 |
| Takeda, U | 1 |
| Sakamoto, K | 1 |
| Seto, N | 1 |
| Igarashi, M | 2 |
| Valsamis, J | 1 |
| Brauman, H | 1 |
| Yourassowsky, E | 1 |
| Slighter, RG | 1 |
| Montenaro, MJ | 1 |
| Fabian, RJ | 1 |
| Bhandari, JC | 1 |
| Donikian, MR | 1 |
| Drobeck, HP | 1 |
| Kalenga, M | 1 |
| Devos, D | 1 |
| Moulin, D | 1 |
| Verellen, G | 1 |
| Bertrand, JM | 1 |
| Mallie, JP | 1 |
| Gerard, H | 1 |
| Gerard, A | 1 |
| Harada, S | 3 |
| Yamamoto, M | 2 |
| Kashitani, J | 2 |
| Deguchi, T | 6 |
| Ikenaga, T | 1 |
| Fujita, T | 3 |
| Takahashi, H | 3 |
| Kohlhepp, SJ | 1 |
| Loveless, MO | 1 |
| Kohnen, PW | 1 |
| Houghton, DC | 1 |
| Bennett, WM | 1 |
| Gilbert, DN | 1 |
| Vaamonde, CA | 2 |
| Bier, RT | 1 |
| Gouvea, W | 2 |
| Alpert, H | 2 |
| Kelley, J | 2 |
| Pardo, V | 2 |
| Smith, AL | 1 |
| Wooton, R | 1 |
| Sanderson, PJ | 1 |
| Nishikawa, S | 2 |
| Miyazaki, H | 3 |
| Ohguro, Y | 3 |
| Akiyoshi, M | 5 |
| Nara, T | 1 |
| Phillips, AM | 1 |
| Milner, RD | 1 |
| Kearns, GL | 1 |
| Hilman, BC | 1 |
| Wilson, JT | 1 |
| Counts, GW | 1 |
| Blair, AD | 1 |
| Wagner, KF | 1 |
| Turck, M | 1 |
| Otaka, T | 2 |
| Miyoshi, K | 4 |
| Nomura, A | 5 |
| Nakayoshi, H | 4 |
| Nakazawa, M | 1 |
| Tokiwa, T | 1 |
| Seno, N | 1 |
| Honda, T | 1 |
| Furuhashi, T | 2 |
| Komuro, E | 1 |
| Uehara, M | 1 |
| Tsujibayashi, K | 1 |
| Bergan, T | 1 |
| Michalsen, H | 1 |
| Kawasaki, H | 1 |
| Yamada, Y | 1 |
| Takei, T | 1 |
| Parravicini, L | 1 |
| Arpini, A | 1 |
| Bamonte, F | 3 |
| Marzanatti, M | 1 |
| Ongini, E | 2 |
| Hallynck, T | 1 |
| Pijck, J | 1 |
| Soep, H | 1 |
| Korsager, S | 1 |
| Hallynck, TH | 1 |
| Soep, HH | 1 |
| Thomis, JA | 1 |
| Boelaert, J | 1 |
| Daneels, R | 1 |
| Dettli, L | 1 |
| Vakoutis, J | 1 |
| Stein, GE | 1 |
| Miller, PB | 1 |
| Clayman, AE | 1 |
| Escoula, L | 1 |
| Camguilhem, R | 1 |
| Larrieu, G | 1 |
| More, J | 1 |
| Haughey, DB | 1 |
| Hilligoss, DM | 1 |
| Grassi, A | 1 |
| Schentag, JJ | 1 |
| Kimura, ET | 1 |
| Tekeli, S | 1 |
| Lewkowski, JP | 1 |
| Majors, KR | 1 |
| Kesterson, JW | 1 |
| Baylis, C | 1 |
| Kahn, T | 1 |
| Bosch, J | 1 |
| Wiener, P | 1 |
| Dikman, S | 1 |
| Fish, K | 1 |
| Sievenpiper, T | 1 |
| Rice, SA | 1 |
| Wharton, RS | 1 |
| Mazze, RI | 3 |
| Bashir, AA | 4 |
| Tanira, MO | 3 |
| Abdel-Gayoum, AA | 1 |
| Ghawarsha, K | 1 |
| Mentré, F | 1 |
| Mallet, A | 1 |
| Leader, WG | 1 |
| Tsubaki, T | 1 |
| Chandler, MH | 2 |
| Roth, D | 1 |
| Montravers, P | 1 |
| Andremont, A | 1 |
| Massias, L | 1 |
| Carbon, C | 1 |
| Graham, JM | 1 |
| Blanco, JD | 1 |
| Oshiro, BT | 1 |
| Magee, KP | 1 |
| Weber, W | 1 |
| Kewitz, G | 1 |
| Rost, KL | 1 |
| Looby, M | 1 |
| Nitz, M | 1 |
| Harnisch, L | 1 |
| Lautermann, J | 1 |
| Schacht, J | 2 |
| Fredelius, L | 1 |
| Dionisotti, S | 1 |
| Wersäll, J | 1 |
| Grauer, GF | 1 |
| Greco, DS | 1 |
| Behrend, EN | 1 |
| Fettman, MJ | 1 |
| Mani, I | 1 |
| Getzy, DM | 1 |
| Reinhart, GA | 1 |
| Davis, GA | 1 |
| Giroux, D | 1 |
| Sirois, G | 1 |
| Martineau, GP | 1 |
| Bashir, AK | 2 |
| Mugamer, IT | 1 |
| Collin, P | 1 |
| Grenier, L | 2 |
| LeBrun, M | 1 |
| Couture, M | 1 |
| Bergeron, MG | 3 |
| Yoshiyama, Y | 1 |
| Gourde, P | 2 |
| Simard, M | 1 |
| Lin, L | 1 |
| Morin, NJ | 1 |
| Chase, H | 1 |
| Austin, TW | 1 |
| Bombassaro, AM | 1 |
| Sharad, S | 1 |
| Doig, GS | 1 |
| Girotti, MJ | 1 |
| Murphy, JE | 3 |
| Severnak, T | 1 |
| García-Delgado, R | 1 |
| Sánchez-Romero, A | 1 |
| Tébar-Gil, R | 1 |
| Marco-Macián, A | 1 |
| Chen, TJ | 1 |
| Chen, SS | 1 |
| Lin, CH | 1 |
| Hsieh, YL | 1 |
| Kale-Pradhan, PB | 1 |
| Buckler, V | 1 |
| Bush, PW | 1 |
| Song, BB | 1 |
| Sha, SH | 1 |
| Austin, ML | 1 |
| Frye, RF | 1 |
| Martín-Jiménez, T | 1 |
| Papich, MG | 1 |
| Riviere, JE | 1 |
| Lingwood, BE | 1 |
| Coghlan, JP | 1 |
| Ward, LC | 1 |
| Charles, BG | 1 |
| Colditz, PB | 1 |
| Parsons, PP | 1 |
| Garland, HO | 1 |
| Harpur, ES | 1 |
| Barletta, JF | 1 |
| Johnson, SB | 1 |
| Nix, DE | 1 |
| Nix, LC | 1 |
| Erstad, BL | 1 |
| Madeddu, P | 1 |
| Vio, CP | 1 |
| Straino, S | 1 |
| Salis, MB | 1 |
| Milia, AF | 1 |
| Emanueli, C | 1 |
| Chattopadhyay, B | 1 |
| Chotigeat, U | 1 |
| Narongsanti, A | 1 |
| Ayudhya, DP | 1 |
| Spreat, SR | 1 |
| Van Hoose, LM | 1 |
| Gailiunas, P | 1 |
| Dominguez-Moreno, M | 1 |
| Lazarus, M | 1 |
| Lowrie, EG | 1 |
| Gottlieb, MN | 1 |
| Merrill, JP | 1 |
| Soberon, L | 1 |
| Bowman, RL | 1 |
| Pastoriza-Munoz, E | 1 |
| Kaloyanides, GJ | 1 |
| Gill, MA | 3 |
| Kern, JW | 1 |
| Ohtani, I | 1 |
| Ohtsuki, K | 1 |
| Omata, T | 1 |
| Ouchi, J | 1 |
| Saito, T | 1 |
| Assael, BM | 2 |
| Gianni, V | 1 |
| Marini, A | 1 |
| Peneff, P | 1 |
| Sereni, F | 1 |
| Schwartz, SN | 1 |
| Pazin, GJ | 1 |
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| Prát, V | 4 |
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| Sato, K | 3 |
| Hull, JH | 1 |
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| Kuramoto, M | 1 |
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| Lee, S | 1 |
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| Nakada, H | 2 |
| Tajima, T | 2 |
| Suzuki, K | 1 |
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| Farag, MM | 1 |
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| Fadali, GA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Tobramycin Administered at the Beginning of Intermittent Hemodialysis Session[NCT03904836] | Phase 1 | 11 participants (Actual) | Interventional | 2019-01-31 | Completed | ||
| A Randomized Clinical Trial Between Clindamycin Once and Thrice a Day in Septic Abortion.[NCT02309346] | Phase 4 | 190 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for gentamicin and Body Weight
| Article | Year |
|---|---|
Clinical Pharmacokinetics of Gentamicin in Various Patient Populations and Consequences for Optimal Dosing for Gram-Negative Infections: An Updated Review.
Topics: Adult; Aged; Anti-Bacterial Agents; Body Weight; Child; Critical Illness; Gentamicins; Humans; Infan | 2022 |
Extended-interval dosing of gentamicin for treatment of neonatal sepsis in developed and developing countries.
Topics: Anti-Bacterial Agents; Body Weight; Developed Countries; Developing Countries; Dose-Response Relatio | 2008 |
Antibiotic pharmacokinetics in newborns.
Topics: Aminoglycosides; Anti-Bacterial Agents; Body Weight; Chloramphenicol; Extracellular Space; Gentamici | 1982 |
Newborns and gentamicin--how much and how often?
Topics: Age Factors; Anti-Bacterial Agents; Body Weight; Drug Administration Schedule; Gentamicins; Humans; | 2002 |
Time course of trough serum gentamicin concentrations in preterm and term neonates.
Topics: Analysis of Variance; Body Weight; Drug Monitoring; Female; Gentamicins; Gestational Age; Humans; In | 1992 |
14 trials available for gentamicin and Body Weight
| Article | Year |
|---|---|
Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.
Topics: Age Factors; Biomarkers; Body Weight; Cefuroxime; Creatinine; Cystatin C; Drug Interactions; Female; | 2009 |
Simplified dosing of gentamicin for treatment of sepsis in Bangladeshi neonates.
Topics: Anti-Bacterial Agents; Bangladesh; Body Weight; Clinical Protocols; Developing Countries; Drug Admin | 2009 |
Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours.
Topics: Adolescent; Adult; Body Weight; Chorioamnionitis; Clindamycin; Double-Blind Method; Endometritis; Fe | 2003 |
Population pharmacokinetics of gentamicin in South African newborns.
Topics: Anti-Bacterial Agents; Body Weight; Female; Gentamicins; Gestational Age; Humans; Infant, Newborn; M | 2003 |
The influence of weight with assay error on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients.
Topics: Anti-Bacterial Agents; Appendicitis; Bayes Theorem; Body Weight; Gentamicins; Half-Life; Humans; Kor | 2005 |
A simple, weight-based, extended-interval gentamicin dosage protocol for neonates.
Topics: Anti-Bacterial Agents; Bacteremia; Body Weight; Drug Administration Schedule; Female; Gentamicins; H | 2005 |
Population pharmacokinetics and dosing of amoxicillin in (pre)term neonates.
Topics: Amoxicillin; Anti-Bacterial Agents; Body Weight; Data Interpretation, Statistical; Drug Administrati | 2006 |
Dosing implications of altered gentamicin disposition in patients with cystic fibrosis.
Topics: Adolescent; Adult; Biopharmaceutics; Body Surface Area; Body Weight; Child; Child, Preschool; Clinic | 1982 |
Gentamicin pharmacokinetics in Native Americans of Apache ancestry.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anti-Bacterial Agents; Body Weight; Female; Genta | 1996 |
Prediction of aminoglycoside distribution space in neonates by multiple frequency bioelectrical impedance analysis.
Topics: Anti-Bacterial Agents; Body Weight; Cohort Studies; Electric Impedance; Female; Gentamicins; Gestati | 1999 |
Gentamicin in neonatal infection: once versus twice daily dosage.
Topics: Age Factors; Anti-Bacterial Agents; Bacterial Infections; Body Weight; Creatinine; Drug Administrati | 2001 |
Gentamicin dosage in children: a randomized prospective comparison of body weight and body surface area as dose determinants.
Topics: Adolescent; Body Surface Area; Body Weight; Child; Child, Preschool; Female; Gentamicins; Half-Life; | 1979 |
Clinical pharmacology of carbenicillin and gentamicin in the neonate and comparative efficacy with ampicillin and gentamicin.
Topics: Age Factors; Ampicillin; Aspartate Aminotransferases; Bacterial Infections; Blood Bactericidal Activ | 1973 |
Efficacy of gentamicin sulfate for the treatment of swine dysentery.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Body Weight; Clinical Trials as Topic; Colon; | 1972 |
197 other studies available for gentamicin and Body Weight
| Article | Year |
|---|---|
Protective role of salicylic acid in gentamicin induced nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Antioxidants; Body Weight; Catalase; Creatinine | 2021 |
Effect of salicylic acid supplementation on blood glucose, lipid profile and electrolyte homeostasis in gentamicin sulphate induced nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Blood Glucose; Body Weig | 2021 |
Protective Effect of Curcumin Against Gentamicin-induced Nephrotoxicity Mediated by p38 MAPK, Nuclear Factor- Kappa B, Nuclear Factor Erythroid 2-Related Factor 2.
Topics: Animals; Body Weight; Curcumin; Drug-Related Side Effects and Adverse Reactions; Gentamicins; Kidney | 2022 |
Salicylic acid protects gentamicin-induced hepatotoxicity: Study in rabbits.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Body Weight; Ch | 2023 |
Simulated Comparison of a Bayesian Clinical Decision Support System Versus Standard of Care For Achieving Gentamicin Pharmacokinetic Targets in Neonates.
Topics: Anti-Bacterial Agents; Bayes Theorem; Birth Weight; Body Weight; Computer Simulation; Decision Suppo | 2020 |
Dose recommendations for gentamicin in the real-world obese population with varying body weight and renal (dys)function.
Topics: Body Weight; Creatinine; Gentamicins; Glomerular Filtration Rate; Humans; Kidney; Obesity, Morbid; P | 2020 |
Pirfenidone attenuates gentamicin-induced acute kidney injury by inhibiting inflammasome-dependent NLRP3 pathway in rats.
Topics: Acute Kidney Injury; Animals; Body Weight; Chemokine CCL2; Gentamicins; Inflammasomes; Kidney Functi | 2020 |
ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats.
Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme 2; Animals; Biomarkers; Body Weight; Cytokines; D | 2020 |
No role for patient body weight on renal function assessment for drug dosing.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Body Weight; Creatinine; Do | 2017 |
Extended-interval Dosing of Gentamicin in Premature Neonates Born at <32 Weeks' Gestation and >7 Days of age.
Topics: Anti-Bacterial Agents; Birth Weight; Body Weight; Drug Administration Schedule; Female; Gentamicins; | 2017 |
Early postnatal gentamicin and ceftazidime treatment in normal and food restricted neonatal wistar rats: Implications for kidney development.
Topics: Animals; Animals, Newborn; Body Weight; Ceftazidime; Diet, Reducing; Female; Food; Gentamicins; Kidn | 2017 |
Potential action of Rumex vesicarius (L.) against potassium dichromate and gentamicin induced nephrotoxicity in experimental rats.
Topics: Animals; Body Weight; Creatinine; Female; Gentamicins; Kidney; Kidney Diseases; Male; Organ Size; Pl | 2018 |
Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Antioxidants; Body Weight; Fertility; Gene Expression R | 2019 |
Potential Association of Weight-Based Gentamicin with Increased Acute Kidney Injury in Urologic Prosthetic Surgery.
Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Body Weight; Gentamicins; Humans; Incidence; Male; | 2019 |
Optimizing Gentamicin Dosing in Pediatrics Using Monte Carlo Simulations.
Topics: Anti-Bacterial Agents; Body Weight; Child; Child, Preschool; Female; Gentamicins; Hospitals; Humans; | 2019 |
HPLC Analysis and In Vivo Renoprotective Evaluation of Hydroalcoholic Extract of Cucumis melo Seeds in Gentamicin-Induced Renal Damage.
Topics: Analysis of Variance; Animals; Antioxidants; Body Weight; Chromatography, High Pressure Liquid; Crea | 2019 |
Population Pharmacokinetic Modeling of Gentamicin in Pediatrics.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bayes Theorem; Body Weight; Child; Child, Preschool; Creat | 2019 |
Influence of multiple courses of therapy on aminoglycoside clearance in adult patients with cystic fibrosis.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Body Height; Body Weight; Cystic Fi | 2013 |
Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis.
Topics: Administration, Oral; Anesthetics, Local; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; | 2013 |
Dose derivation of once-daily dosing guidelines for gentamicin in critically ill pediatric patients.
Topics: Administration, Intravenous; Adolescent; Anti-Bacterial Agents; Area Under Curve; Body Weight; Child | 2014 |
Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration.
Topics: Adolescent; Adult; Aging; Body Weight; Child; Child, Preschool; Creatinine; Gentamicins; Glomerular | 2014 |
Population pharmacokinetic study of gentamicin in a large cohort of premature and term neonates.
Topics: Anti-Bacterial Agents; Birth Weight; Body Weight; Cohort Studies; Computer Simulation; Dose-Response | 2014 |
Costus afer ker gawl leaves against gentamicin-induced nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Body Weight; Costus; Creatinine; Drinking; Eating; Electrolytes; Genta | 2014 |
Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats.
Topics: Animals; Blood Glucose; Body Weight; Disease Progression; Drug Combinations; Fructose; Gentamicins; | 2014 |
Urinary excretion pattern of exosomal aquaporin-2 in rats that received gentamicin.
Topics: Animals; Anti-Bacterial Agents; Aquaporin 2; Body Weight; Calcium-Binding Proteins; DNA-Binding Prot | 2014 |
Population pharmacokinetics of gentamicin and dosing optimization for infants.
Topics: Anti-Bacterial Agents; Biomarkers, Pharmacological; Body Weight; Child, Preschool; Creatinine; Dose- | 2015 |
Nephro-protective potential of Morus alba, a prospective experimental study on animal models.
Topics: Animals; Body Weight; Drugs, Chinese Herbal; Free Radical Scavengers; Fruit; Gentamicins; Kidney; Ma | 2016 |
Comparison of the Protective Effects of Melatonin and Silymarin Against Gentamicin-Induced Nephrotoxicity in Rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Body Weight; Creatinine; Gentamicins; Glutathione; Kidne | 2016 |
In vivo evaluation of the anti-infection potential of gentamicin-loaded nanotubes on titania implants.
Topics: Animals; Anti-Bacterial Agents; Body Weight; Femur; Gentamicins; Male; Microbial Sensitivity Tests; | 2016 |
Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model.
Topics: Animals; Biomarkers; Body Weight; Diagnostic Tests, Routine; Disease Models, Animal; Drinking Water; | 2016 |
Scaling clearance in paediatric pharmacokinetics: All models are wrong, which are useful?
Topics: Age Factors; Body Weight; Child; Gentamicins; Humans; Midazolam; Models, Biological; Pharmacokinetic | 2017 |
Fagonia olivieri prevented hepatorenal injuries induced with gentamicin in rat.
Topics: Animals; Antioxidants; Biomarkers; Body Weight; DNA Damage; Gas Chromatography-Mass Spectrometry; Ge | 2017 |
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle.
Topics: Animals; Aquaporin 4; Body Weight; Calcium; Dystrophin; Gentamicins; Homeostasis; In Vitro Technique | 2008 |
Pathological effects of gentamicin administered intramuscularly to day-old broiler chicks.
Topics: Animals; Anti-Bacterial Agents; Body Weight; Chickens; Depression; Dose-Response Relationship, Drug; | 2009 |
Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Body Weight; Creatinine; Gentamicins; Ki | 2009 |
Salmonella administration induces a reduction of wheel-running activity via a TLR5-, but not a TLR4, dependent pathway in mice.
Topics: Animals; Body Weight; Cell Line; Flagellin; Gentamicins; Hot Temperature; Immunity, Innate; Lipopoly | 2008 |
Indomethacin, ibuprofen and gentamicin administered during late stages of glomerulogenesis do not reduce glomerular number at 14 days of age in the neonatal rat.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Anti-Bacterial Agents; Body Weight; Cardiovascu | 2009 |
Modified diet in renal disease method overestimates renal function in selected elderly patients.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Bias; Body Weight; Cr | 2009 |
Once-daily gentamicin dosing in children with febrile neutropenia resulting from antineoplastic therapy.
Topics: Adolescent; Aging; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Child; Child, Preschoo | 2010 |
Gentamicin dosing for pediatric patients with congenital heart disease.
Topics: Adolescent; Anti-Bacterial Agents; Body Weight; Child; Child, Preschool; Dose-Response Relationship, | 2010 |
Sub-acute toxicity study of a new aminoglycoside etimicin sulphate in swiss albino mice.
Topics: Animals; Anti-Bacterial Agents; Blood Glucose; Body Weight; Gentamicins; Kidney; Liver; Mice; No-Obs | 2010 |
Improved hatchability and posthatch performance in turkey poults receiving a dextrin-iodinated casein solution in ovo.
Topics: Animals; Body Weight; Caseins; Dose-Response Relationship, Drug; Eggs; Embryo, Nonmammalian; Female; | 2010 |
Gentamicin pharmacokinetics in old age and frailty.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Body Weight; Creatinine; Fem | 2011 |
Reno-protective role of flunarizine (mitochondrial permeability transition pore inactivator) against gentamicin induced nephrotoxicity in rats.
Topics: Animals; Body Weight; Cyclosporine; Flunarizine; Gentamicins; Kidney Diseases; Male; Mitochondrial M | 2011 |
Once-daily-dosing intramuscular gentamicin in neonates.
Topics: Anti-Bacterial Agents; Bacteremia; Body Weight; Drug Dosage Calculations; Female; Gentamicins; Gesta | 2012 |
Development of criteria for gentamicin monitoring in a neonatal intensive care unit.
Topics: Body Weight; Cohort Studies; Drug Monitoring; Female; Gentamicins; Humans; Infant, Newborn; Infant, | 2012 |
Gentamicin in hemodialyzed critical care patients: early dialysis after administration of a high dose should be considered.
Topics: Anti-Bacterial Agents; Body Mass Index; Body Weight; Critical Care; Critical Illness; Drug Administr | 2013 |
Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates.
Topics: Anti-Bacterial Agents; Apgar Score; Bayes Theorem; Body Weight; Demography; Dose-Response Relationsh | 2002 |
Dietary composition alters gentamicin-induced nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Animal Nutritional Physiological Phenomena; Animals; Anti-Bacterial Agents; B | 2002 |
Chinchilla models of selective cochlear hair cell loss.
Topics: Animals; Anti-Bacterial Agents; Body Weight; Cell Death; Chinchilla; Cochlea; Diuretics; Dose-Respon | 2002 |
Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats.
Topics: Animals; Anti-Bacterial Agents; Body Temperature; Body Weight; Bone Wires; Female; Gentamicins; Leuk | 2003 |
Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage.
Topics: Acetylglucosaminidase; Animals; Anti-Bacterial Agents; Antioxidants; Body Weight; Cysteine; Free Rad | 2003 |
Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Body Weight; Catalase; Free Radical Scavengers; G | 2003 |
Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats.
Topics: Acetylglucosaminidase; Allyl Compounds; Animals; Anti-Bacterial Agents; Antioxidants; Blood Urea Nit | 2003 |
Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.
Topics: Amino Acids, Diamino; Animals; Body Weight; Brain Stem; Dystrophin; Gene Expression Regulation; Gent | 2003 |
S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo.
Topics: Aldehydes; Animals; Biomarkers; Body Weight; Carboxylic Acids; Cysteine; Dinitrophenols; Energy Inta | 2004 |
Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides.
Topics: Adult; Aged; Aging; Aminoglycosides; Anti-Bacterial Agents; Body Weight; Creatinine; Female; Gentami | 2004 |
Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Body Weight; Creatinine; Drug Synergism; Genta | 2004 |
Systemic versus local application of gentamicin in prophylaxis of implant-related osteomyelitis in a rat model.
Topics: Animals; Anti-Bacterial Agents; Body Temperature; Body Weight; Drug Administration Routes; Female; G | 2005 |
Factors related to recurrence of spontaneous pneumothorax.
Topics: Adult; Anti-Bacterial Agents; Body Height; Body Weight; China; Drainage; Female; Follow-Up Studies; | 2005 |
The influence of assay error weight on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients.
Topics: Anti-Bacterial Agents; Appendicitis; Bayes Theorem; Body Weight; Female; Gentamicins; Humans; Least- | 2005 |
Population pharmacokinetics of gentamicin in premature newborns.
Topics: Age Factors; Anti-Bacterial Agents; Blood Chemical Analysis; Body Weight; Drug Administration Schedu | 2006 |
Comparative pharmacokinetics of gentamicin after intravenous, intramuscular, subcutaneous and oral administration in broiler chickens.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Body Weight; Chickens; Female; Gentamicins; In | 2007 |
Time dependent effect of gentamicin on enzymes of carbohydrate metabolism and terminal digestion in rat intestine.
Topics: Alkaline Phosphatase; Animals; Anti-Bacterial Agents; Body Weight; Carbohydrate Metabolism; Catalase | 2007 |
Effect of some simple manoeuvres on the course of acute renal failure after gentamycin treatment in rats.
Topics: Acute Kidney Injury; Animals; Bicarbonates; Body Weight; Creatinine; Drinking; Eating; Female; Fluid | 1984 |
The comparative ototoxicities of panimycin and gentamicin in cynomolgus monkeys (Macaca fascicularis).
Topics: Acoustic Maculae; Aminoglycosides; Animals; Body Weight; Dibekacin; Female; Gentamicins; Kanamycin; | 1984 |
Plasma beta 2 microglobulin as a means of predicting gentamicin serum concentrations.
Topics: Adult; Aged; beta 2-Microglobulin; Beta-Globulins; Body Weight; Child; Creatinine; Gentamicins; Glom | 1980 |
Comparative nephrotoxicity of hydroxygentamicin and other aminoglycosides in rats.
Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Body Weight; Creatin | 1984 |
The need for pharmacokinetic monitoring of gentamicin therapy in critically ill neonates.
Topics: Body Weight; Gentamicins; Gestational Age; Glomerular Filtration Rate; Half-Life; Humans; Infant, Ne | 1984 |
Gentamicin administration to pregnant rats: effect on fetal renal development in utero.
Topics: Animals; Body Weight; Female; Gentamicins; Kidney; Organ Size; Pregnancy; Rats; Rats, Inbred Strains | 1984 |
[Safety evaluation of micronomicin V. Subacute toxicity in rats after intravenous injection].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Drinking; Female; Gentamicins; Injecti | 1983 |
[Safety evaluation of micronomicin VI. Subacute toxicity in rabbits after drip intravenous infusion].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Diuresis; Eating; Gentamicins; Infusio | 1983 |
[Safety evaluation of micronomicin VII. Fertility study by intravenous injection in rats].
Topics: Abnormalities, Drug-Induced; Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Female; F | 1983 |
[Safety evaluation of micronomicin VIII. Teratogenicity studies in rabbits after intravenous injection].
Topics: Abnormalities, Drug-Induced; Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Female; F | 1983 |
[Safety evaluation of micronomicin IX. Perinatal and postnatal study by intravenous injection in rats].
Topics: Aminoglycosides; Animals; Animals, Newborn; Anti-Bacterial Agents; Body Weight; Female; Gentamicins; | 1983 |
Nephrotoxicity of the constituents of the gentamicin complex.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Creatinine; Gentamicins; Kidney; Kidney | 1984 |
Effect of duration of diabetes on the protection observed in the diabetic rat against gentamicin-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Body Weight; Diabetes Mellitus, Experimental; Drinking; Feeding Behavi | 1984 |
Forecasting antibiotic regimens using impulse analysis.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Biological Assay; Body Height; Body Weight; Drug Administr | 1980 |
[Safety evaluation of micronomicin. I. Subacute and chronic toxicity in dogs].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Blood Chemical Analysis; Body Weight; Dogs; Drug Ev | 1983 |
[Safety evaluation of micronomicin. III. Teratogenicity studies in rats].
Topics: Abnormalities, Drug-Induced; Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Drug Eval | 1983 |
[Effect of intravenous administration of micronomicin on the inner ear of guinea pigs].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Drug Evaluation, Preclinical; Ear, Inn | 1983 |
Clinical pharmacology of netilmicin in the newborn.
Topics: Body Weight; Drug Administration Schedule; Gentamicins; Humans; Infant, Newborn; Infant, Premature; | 1983 |
Gentamicin and tobramycin Kinetics.
Topics: Adult; Aged; Anti-Bacterial Agents; Body Weight; Female; Gentamicins; Humans; Injections, Intravenou | 1982 |
[Acute and subacute toxicity studies on netilmicin (author's transl)].
Topics: Animals; Blood Chemical Analysis; Body Weight; Female; Gentamicins; Hearing Tests; Hematologic Tests | 1982 |
[Chronic toxicity study on netilmicin in rats (author's transl)].
Topics: Animals; Blood Chemical Analysis; Body Weight; Drinking; Eating; Female; Gentamicins; Hematologic Te | 1982 |
[Thirty-day subacute intramuscular toxicity study and thirty-day recovery study of netilmicin in beagle dogs (author's transl)].
Topics: Animals; Blood Chemical Analysis; Body Weight; Dogs; Drinking; Eating; Female; Gentamicins; Hematolo | 1982 |
[Reproduction study on netilmicin. (1) Teratological study in rats (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Drinking; Eat | 1982 |
[Reproduction study on netilmicin. (3) Perinatal and postnatal study in rats (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Female; Fertility; Fetus; Genta | 1982 |
Pharmacokinetic assessment of netilmicin in newborns and older children.
Topics: Adolescent; Age Factors; Bacterial Infections; Body Surface Area; Body Weight; Child; Child, Prescho | 1982 |
[Ototoxicity study of netilmicin in pregnant guinea pigs and the embryo].
Topics: Animals; Animals, Newborn; Body Weight; Ear, External; Ear, Inner; Female; Fetal Death; Fetus; Genta | 1982 |
Comparative ototoxicity of amikacin, gentamicin, netilmicin, and tobramycin in guinea pigs.
Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Cochlea; Ear Diseases; Elect | 1982 |
Influence of age and lean body mass on the relation of creatinine clearance and drug half-life.
Topics: Adolescent; Aging; Amikacin; Body Weight; Child; Child, Preschool; Creatinine; Female; Gentamicins; | 1982 |
Administration o gentamicin to obese patients.
Topics: Adipose Tissue; Aged; Body Weight; Female; Gentamicins; Humans; Male; Middle Aged; Models, Biologica | 1980 |
Should clearance be normalised to body surface or to lean body mass?
Topics: Aging; Body Surface Area; Body Weight; Child; Child, Preschool; Creatinine; Female; Gentamicins; Hal | 1981 |
Aminoglycoside monitoring program.
Topics: Aminoglycosides; Anti-Bacterial Agents; Body Weight; Gentamicins; Humans; Kinetics; Tobramycin | 1981 |
[Sensibility of rabbits to treatment with ampicillin and gentamycin (author's transl)].
Topics: Administration, Oral; Ampicillin; Animals; Bacteria; Body Weight; Cecum; Drug Resistance; Gentamicin | 1981 |
Two-compartment gentamicin pharmacokinetics in premature neonates: a comparison to adults with decreased glomerular filtration rates.
Topics: Adult; Aged; Bacterial Infections; Body Surface Area; Body Weight; Dose-Response Relationship, Drug; | 1980 |
Acute and subacute toxicity studies with fortimicin A sulfate (Abbott-44747), a new aminoglycoside antibiotic.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Cats; Dogs; Dose-Response Relationship | 1980 |
Altered gentamicin distribution in ascitic patients.
Topics: Ascites; Body Weight; Gentamicins; Humans | 1980 |
The mechanism of the decline in glomerular filtration rate in gentamicin-induced acute renal failure in the rat.
Topics: Acute Kidney Injury; Animals; Body Weight; Gentamicins; Glomerular Filtration Rate; Hydrostatic Pres | 1980 |
Course of gentamicin nephrotoxicity.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Creatinine; Electrolytes; Gentamicins; Hematocrit; Kidney | 1980 |
Renal function in Fischer 344 rats with chronic renal impairment after administration of enflurane and gentamicin.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Body Weight; Chronic Disease; Creatinine; Enflura | 1980 |
The effect of thyroxine or carbimazole treatment on gentamicin nephrotoxicity in rats.
Topics: Animals; Body Weight; Carbimazole; Creatinine; Female; Gentamicins; Kidney Diseases; Rats; Rats, Spr | 1995 |
Plasma lipid profile in rats with gentamicin-induced nephrotoxicity.
Topics: Alkaline Phosphatase; Animals; Body Weight; Cholesterol; Creatinine; Female; Gentamicins; Injections | 1993 |
Handling covariates in population pharmacokinetics.
Topics: Age Factors; Apgar Score; Body Weight; Drug Administration Schedule; Drug Therapy, Computer-Assisted | 1994 |
Creatinine-clearance estimates for predicting gentamicin pharmacokinetic values in obese patients.
Topics: Adult; Bias; Body Surface Area; Body Weight; Creatinine; Female; Gentamicins; Humans; Male; Metaboli | 1994 |
Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat.
Topics: Animals; Body Weight; Creatine; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Hy | 1994 |
Investigation of the potential role of Enterococcus faecalis in the pathophysiology of experimental peritonitis.
Topics: Abscess; Amoxicillin; Animals; Anti-Bacterial Agents; Bacteremia; Bacteroides fragilis; Bacteroides | 1994 |
Gentamicin levels in pregnant women with pyelonephritis.
Topics: Adult; Ampicillin; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Female; Gen | 1994 |
Comparative modulating effects of captopril, diltiazem, dietary calcium and pyridoxal-5'-phosphate on gentamicin-induced nephrotoxicity in the rat.
Topics: Animals; Body Weight; Calcium, Dietary; Captopril; Diltiazem; Female; Gentamicins; Glutathione; Inje | 1993 |
Population kinetics of gentamicin in neonates.
Topics: Body Weight; Fluorescence Polarization Immunoassay; Gentamicins; Gestational Age; Humans; Infant, Ne | 1993 |
[Reduced nutritional status enhances ototoxicity].
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Auditory Pathways; Auditory Threshold; Body W | 1995 |
Auditory impairment in guinea pigs treated with isepamicin.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Auditory Threshold; Body Weight; Brain; Cochlear Duct; Dos | 1995 |
Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs.
Topics: Animals; Body Weight; Creatinine; Diet; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Eating | 1996 |
Comparison of creatinine clearance estimation methods in patients with trauma.
Topics: Adult; Age Factors; Anti-Bacterial Agents; Body Weight; Creatinine; Female; Gentamicins; Glomerular | 1996 |
Gentamicin pharmacokinetics in newborn and 42-day-old male piglets.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Body Weight; Chromatography, High Pressure Liquid; | 1995 |
Gentamicin nephrotoxicity in the rat: influence of age and diabetes mellitus.
Topics: Aging; Animals; Anti-Bacterial Agents; Body Weight; Copper; Diabetes Mellitus, Experimental; Gentami | 1996 |
Effects of fasting on temporal variations in nephrotoxicity of gentamicin in rats.
Topics: Animals; Anti-Bacterial Agents; Body Weight; Drinking; Eating; Fasting; Female; Gentamicins; Immunoh | 1996 |
Temporal variation in nephrotoxicity of low doses of isepamicin in rats.
Topics: Animals; Anti-Bacterial Agents; Body Weight; Circadian Rhythm; Gentamicins; Immunohistochemistry; In | 1996 |
Standardized gentamicin dosing enhances peak serum concentrations.
Topics: Adolescent; Adult; Aged; Body Weight; Creatinine; Drug Administration Schedule; Female; Fever; Genta | 1996 |
Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats.
Topics: Aging; Animals; Anti-Bacterial Agents; Blood Glucose; Blood Proteins; Body Weight; Creatinine; Eatin | 1997 |
[Monitoring of gentamycin serum concentration in neonates. Usefulness in adjustment of dosage].
Topics: Anti-Bacterial Agents; Body Weight; Dose-Response Relationship, Drug; Gentamicins; Gestational Age; | 1997 |
Synergestic effects of noise and aminoglycoside antibiotic (gentamicin) on auditory function in the gerbil.
Topics: Animals; Anti-Bacterial Agents; Body Weight; Evoked Potentials, Auditory, Brain Stem; Gentamicins; G | 1997 |
Effect of body weight on aminoglycoside pharmacokinetics in patients with hypoalbuminemia.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Biological Availability; Body Weight; Female; | 1997 |
Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Body Weight; Cochlea; Creatini | 1998 |
Evaluation of gentamicin pharmacokinetics and dosing protocols in 195 neonates.
Topics: Body Weight; Female; Gentamicins; Humans; Infant, Newborn; Male; Metabolic Clearance Rate | 1998 |
Population pharmacokinetics of gentamicin in horses.
Topics: Age Factors; Animals; Anti-Bacterial Agents; Body Weight; Creatinine; Female; Gentamicins; Horse Dis | 1998 |
Localization of the nephron site of gentamicin-induced hypercalciuria in the rat: a micropuncture study.
Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Body Weight; Calcium; Gentamicins; Kidney Tubules, D | 2000 |
Population pharmacokinetics of aminoglycosides in critically ill trauma patients on once-daily regimens.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Bacterial Agents; Body Weight; Creatinine; Critical Illne | 2000 |
Renal phenotype of low kallikrein rats.
Topics: Angiotensin Receptor Antagonists; Animals; Anti-Bacterial Agents; Blood Volume; Body Weight; Gentami | 2001 |
Tissue concentrations in dogs treated with gentamicin.
Topics: Animals; Body Weight; Dog Diseases; Dogs; Gentamicins; Staphylococcal Infections; Time Factors | 1979 |
Vestibular toxicity of gentamicin. Incidence in patients receiving long-term hemodialysis therapy.
Topics: Adult; Aged; Body Weight; Female; Gentamicins; Humans; Kidney Failure, Chronic; Labyrinth Diseases; | 1978 |
Comparative nephrotoxicities of gentamicin, netilmicin and tobramycin in the rat.
Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Body Weight; Creatinine; Gentamicins; Kidney; K | 1979 |
Altered gentamicin distribution in ascitic patients.
Topics: Adult; Aged; Ascites; Blood Proteins; Body Weight; Extracellular Space; Female; Gentamicins; Humans; | 1979 |
Potentiation and its mechanism of cochlear damage resulting from furosemide and aminoglycoside antibiotics.
Topics: Aminoglycosides; Animals; Body Fluids; Body Weight; Cochlea; Drug Synergism; Furosemide; Gentamicins | 1978 |
Gentamicin dosage in preterm and term neonates.
Topics: Body Weight; Child, Preschool; Gentamicins; Gestational Age; Humans; Infant; Infant, Newborn; Infant | 1977 |
A controlled investigation of the pharmacokinetics of gentamicin and tobramycin in obese subjects.
Topics: Anti-Bacterial Agents; Body Weight; Gentamicins; Humans; Kinetics; Obesity; Tobramycin | 1978 |
Nephrotoxic antibiotics in patients with renal failures: guidelines for debilitated patients.
Topics: Aminoglycosides; Body Weight; Creatine; Emaciation; Gentamicins; Humans; Kidney; Kidney Failure, Chr | 1979 |
An experimental model of Pseudomonas aeruginosa renal infection in rats.
Topics: Bacteriuria; Body Weight; Carbenicillin; Disease Models, Animal; Drug Evaluation; Drug Therapy, Comb | 1975 |
Effect of drugs on infant Gunn rats under phototherapy.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Benzyl Alcohols; Bilirubin; Body Weight; Cerebellu | 1976 |
Gentamicin dosage and lean body mass.
Topics: Body Weight; Gentamicins; Humans | 1977 |
Gentamicin dosage.
Topics: Body Weight; Creatinine; Gentamicins; Glomerular Filtration Rate; Humans | 1977 |
[Safety evaluation of KW-1062. I. Acute toxicity in mice, rats and dogs, subacute and chronic toxicity in rats (author's transl)].
Topics: Adrenal Glands; Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Bone Marrow; Dogs; Dos | 1977 |
[Ototoxic effects of some aminoglycoside antibiotics on the inner ear in the spontaneously hypertensive rats (SHR) (author's transl)].
Topics: Animals; Anti-Bacterial Agents; Body Weight; Dibekacin; Disease Models, Animal; Ear, Inner; Gentamic | 1977 |
Gentamicin serum concentrations: pharmacokinetic predictions.
Topics: Adolescent; Adult; Aged; Body Weight; Carbenicillin; Computers; Creatinine; Gentamicins; Hematocrit; | 1976 |
Calculating gentamicin doses.
Topics: Body Constitution; Body Height; Body Weight; Drug Administration Schedule; Female; Gentamicins; Huma | 1976 |
Effects of gentamicin on the intestinal bacterial flora of rats.
Topics: Animals; Body Weight; Candida; Drug Resistance, Microbial; Enterobacteriaceae; Escherichia coli; Fec | 1975 |
[Evaluation of ototoxicity of amikacin (BB-K8) by animal test (author's transl)].
Topics: Amikacin; Animals; Auditory Threshold; Body Weight; Gentamicins; Guinea Pigs; Hearing; Hearing Disor | 1975 |
Novel method for the determination of pediatric dosages.
Topics: Age Factors; Body Surface Area; Body Water; Body Weight; Female; Gentamicins; Humans; Infant, Newbor | 1976 |
Verapamil increases the nephrotoxic potential of gentamicin in rats.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Creatinine; Drug Interactions; Gentamicins; Injections, I | 1992 |
Gentamicin nephrotoxicity in rat: some biochemical correlates.
Topics: Amine Oxidase (Copper-Containing); Animals; Body Weight; Creatinine; Dose-Response Relationship, Dru | 1992 |
Variation in the pharmacokinetics of gentamicin and tobramycin in patients with pleural effusions and hypoalbuminemia.
Topics: Aged; Aging; Body Weight; Female; Fluorescence Polarization Immunoassay; Gentamicins; Half-Life; Hum | 1992 |
Use of gentamicin clearance in estimating renal function.
Topics: Adolescent; Adult; Appendicitis; Body Weight; Creatinine; Female; Gentamicins; Humans; Kidney Functi | 1991 |
Iron supplementation increases gentamicin nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Body Weight; Diet; Gentamicins; Iron; Kidney Function Tests; Male; Nut | 1991 |
Gentamicin dosing services in the absence of 24-hour pharmaceutical services.
Topics: Body Weight; Gentamicins; Humans; Pharmacy Service, Hospital; Time Factors | 1991 |
Influence of copper nutrition on gentamicin nephrotoxicity in rats.
Topics: Animals; Body Weight; Copper; Gentamicins; Kidney; Liver; Male; Organ Size; Rats; Rats, Inbred Strai | 1990 |
Gentamicin volume of distribution in critically ill septic patients.
Topics: Adult; Aged; Bacterial Infections; Body Weight; Critical Care; Extracellular Space; Female; Gentamic | 1990 |
Variation in plasma halflife of gentamicin between species in relation to bodyweight and taxonomy.
Topics: Animals; Birds; Body Weight; Gentamicins; Half-Life; Least-Squares Analysis; Mammals; Regression Ana | 1990 |
Expanded gentamicin volume of distribution in patients with indicators of malnutrition.
Topics: Adult; Aged; Body Composition; Body Weight; Gentamicins; Humans; Middle Aged; Nutrition Disorders; N | 1990 |
Evaluation of six gentamicin nomograms using a bayesian parameter estimation program.
Topics: Bayes Theorem; Body Weight; Creatinine; Gentamicins; Humans; Metabolic Clearance Rate; Predictive Va | 1990 |
Prolonged endotoxemia enhances the renal injuries induced by gentamicin in rats.
Topics: Animals; Body Weight; Drug Synergism; Endotoxins; Female; Gentamicins; Hematocrit; Kidney; Kidney Co | 1990 |
Protective effect of thyroxine but not parathyroidectomy on gentamicin nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Body Weight; Calcium; Extracellular Space; Gentamicins; Glomerular Fil | 1985 |
A comparison of the effects of tetraplatin and cisplatin on renal function and gentamicin pharmacology in rats.
Topics: Animals; Antineoplastic Agents; Body Weight; Cisplatin; Gentamicins; Kidney; Kidney Function Tests; | 1989 |
Gentamicin volume of distribution as a power function of body weight.
Topics: Adult; Body Weight; Gentamicins; Humans; Infant; Infant, Newborn; Obesity | 1989 |
Effect of glucarolactam on low-dose nephrotoxicities of dibekacin and gentamicin in Fischer rats.
Topics: Animals; Body Weight; Creatinine; Dibekacin; Gentamicins; Glucaric Acid; Kanamycin; Kidney; Kidney D | 1989 |
Gentamicin solution for mediastinal irrigation: systemic absorption, bactericidal activity, and toxicity.
Topics: Absorption; Adult; Aged; Aged, 80 and over; Body Surface Area; Body Weight; Creatinine; Female; Gent | 1989 |
Effect of gentamicin on urinary acidification in the rat.
Topics: Ammonia; Animals; Bicarbonates; Body Weight; Carbon Dioxide; Gentamicins; Glomerular Filtration Rate | 1986 |
The effect of dietary protein restriction on high dose gentamicin nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Animals; Body Weight; Creatinine; Dietary Proteins; Gentamicins; Kidney; Kidn | 1988 |
Comparative ototoxicity of gentamicin in the guinea pig and two strains of rats.
Topics: Animals; Body Weight; Brain Stem; Cochlea; Evoked Potentials, Auditory; Gentamicins; Guinea Pigs; Ki | 1987 |
[Toxicological studies on isepamicin (HAPA-B). II. Intramuscular subacute toxicity test in the rat].
Topics: Amikacin; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Gentamicins; Injections, I | 1986 |
[Effect of isepamicin (HAPA-B) on reproduction. I. Fertility study in rats (intramuscular administration)].
Topics: Animals; Body Weight; Female; Fertility; Gentamicins; Injections, Intramuscular; Male; Pregnancy; Pr | 1986 |
[Effect of isepamicin (HAPA-B) on reproduction. IV. Peri- and post-natal study in rats (intramuscular administration)].
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Feeding Behavior; Female; Gentamicins; Inj | 1986 |
Alterations in aminoglycoside volume of distribution in patients below ideal body weight.
Topics: Adult; Aged; Amikacin; Body Weight; Female; Gentamicins; Humans; Male; Middle Aged; Retrospective St | 1987 |
More on variability in aminoglycoside volume of distribution.
Topics: Adult; Aged; Amikacin; Body Weight; Critical Care; Gentamicins; Humans; Middle Aged; Surgical Proced | 1987 |
[Evaluation of ototoxic effect of micronomicin by intravenous drip infusion].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Cochlea; Ear, Inner; Gentamicins; Guin | 1985 |
Prostaglandins and aminoglycoside nephrotoxicity.
Topics: Analysis of Variance; Animals; Aspirin; Blood Urea Nitrogen; Body Weight; Creatinine; Drug Interacti | 1985 |
Skin and mucous membrane ulceration in beagle dogs following oral dosing with an experimental aminoglycoside antibiotic.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Body Weight; Dogs; Female; Gentamicins; Male; Mouth | 1985 |
Nephrotoxicity of aminoglycosides in young and adult rats.
Topics: Age Factors; Amikacin; Animals; Biological Transport, Active; Body Weight; Gentamicins; Glomerular F | 1985 |
Serum levels of gentamicin and tobramycin after slow intravenous bolus injection.
Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Biological Assay; Body Weight; Female; Gentamicins; H | 1974 |
Letter: Serum-gentamicin levels after intravenous bolus injection.
Topics: Body Weight; Dose-Response Relationship, Drug; Gentamicins; Humans; Injections, Intravenous; Jaundic | 1974 |
Parenteral nutrition in the burned child: a study of twenty-six patients.
Topics: Adolescent; Anti-Bacterial Agents; Bacterial Infections; Body Surface Area; Body Weight; Burns; Cath | 1974 |
[Ototoxic effect of 3',4'-dideoxykanamycin B on the inner ear in the intrauterine guinea pigs (author's transl)].
Topics: Acoustic Stimulation; Animals; Body Weight; Dibekacin; Ear, Inner; Embryo, Mammalian; Female; Gentam | 1974 |
Hyponatraemia syndrome in acute myeloid leukaemia.
Topics: Adult; Ampicillin; Blood Cell Count; Body Weight; Bone Marrow Cells; Chlorides; Cloxacillin; Cytarab | 1974 |
Concentration of gentamicin in serum, urine and urogenital tissue in man.
Topics: Aged; Body Weight; Gentamicins; Humans; Injections, Intramuscular; Kidney Cortex; Kidney Medulla; Ma | 1973 |
[Evaluation of effect of lividomycin in urinary tract infections. I. Effects of lividomycin on experimental pyelonephritis in rabbits].
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Body Weight; Evaluation Studies as T | 1972 |
Gentamicin in acute and chronic pyelonephritis.
Topics: Acute Disease; Aged; Bacillus; Body Weight; Chronic Disease; Creatinine; Enterobacteriaceae Infectio | 1973 |
[The influence of test-animal age on antibiotic toxicity indices].
Topics: Age Factors; Animals; Animals, Newborn; Anti-Bacterial Agents; Body Weight; Brain; Erythromycin Ethy | 1974 |
[Experimental studies on decreasing Streptomyces antibiotic ototoxicity by dividing the daily dosage].
Topics: Animals; Body Weight; Cochlea; Gentamicins; Guinea Pigs; Hearing Disorders; Hearing Tests; Injection | 1972 |
Combined nephrotoxicity of gentamicin and methoxyflurane anaesthesia in man. A case report.
Topics: Anesthesia, Inhalation; Blood Urea Nitrogen; Body Weight; Creatinine; Drug Synergism; Fluorides; Gen | 1973 |
Nephrotoxicity of gentamicin.
Topics: Acid Phosphatase; Acute Kidney Injury; Animals; Anuria; Blood Urea Nitrogen; Body Weight; Dose-Respo | 1974 |
[Antibacterial effect of two sulfonamide compoundds in acute experimental E. coli-pyelonephritis].
Topics: Acute Disease; Animals; Bacteriuria; Body Weight; Escherichia coli; Escherichia coli Infections; Fem | 1969 |
Pharmacologic evaluation of gentamicin in newborn infants.
Topics: Age Factors; Bacterial Infections; Body Weight; Central Nervous System Diseases; Fetal Hemoglobin; G | 1971 |
Effect of carbenicillin, gentamicin, and their combination on experimental Pseudomonas aeruginosa urinary tract infection.
Topics: Animals; Body Weight; Drug Synergism; Female; Gentamicins; Kidney; Penicillins; Pseudomonas aerugino | 1971 |
Experimental ototoxicity of gentamicin in squirrel monkeys.
Topics: Animals; Ataxia; Avoidance Learning; Body Weight; Cochlea; Ear, Inner; Eye Movements; Female; Gentam | 1971 |
Urinary excretion of gentamicin in the neonatal period.
Topics: Age Factors; Bacterial Infections; Body Weight; Creatinine; Gentamicins; Half-Life; Humans; Infant, | 1971 |
Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.
Topics: Adult; Age Factors; Body Weight; Ear, Inner; Gentamicins; Hearing Disorders; Humans; Kidney Diseases | 1971 |
[Carbenicillin and gentamicin in experimental Pseudomonas cystitis].
Topics: Animals; Body Weight; Cystitis; Disease Models, Animal; Female; Gentamicins; Penicillins; Pseudomona | 1969 |