gentamicin and Blood Poisoning studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

Excerpt	Relevance	Reference
"120 neonates aged ≤28 days admitted being treated with standard-of-care (SOC) antibiotics for sepsis: ampicillin and gentamicin between March 2018 and February 2019."	9.51	Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload. ( Berkley, JA; Correia, E; Egondi, T; Ellis, S; Gastine, S; Kane, Z; Kipper, K; Murunga, S; Nyaoke, B; Obiero, CW; Omollo, R; Sharland, M; Standing, JF; Thitiri, J; Walker, AS; Williams, P, 2022)
"This study aimed to simultaneously investigate the pharmacokinetics of ampicillin and gentamicin, currently the WHO standard of care for treating neonatal sepsis."	9.51	Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis. ( Berkley, JA; Correia, E; Ellis, S; Gastine, S; Kane, Z; Kipper, K; Murunga, S; Nyaoke, B; Obiero, C; Readman, J; Sharland, M; Standing, JF; Thitiri, J; van den Anker, J; Williams, P, 2022)
"The primary objective was to determine if initial empirical intravenous dosing of gentamicin improved patient's outcomes in pyelonephritis/urosepsis compared with alternative IV antibiotic management."	9.30	The use of initial dosing of gentamicin in the management of pyelonephritis/urosepsis: A retrospective study. ( Czarniak, P; Parsons, R; Ryanto, S; Skinner, M; Sunderland, B; Travers, K; Wong, M, 2019)
"Extended-interval dosing of gentamicin has several advantages over conventional multiple-daily dosing for the treatment of sepsis."	9.14	Simplified dosing of gentamicin for treatment of sepsis in Bangladeshi neonates. ( Aranda, J; Chowdhury, NA; Coffey, P; Darmstadt, GL; Edwards, D; Hossain, MM; Miller-Bell, M; Saha, SK; Shirin, M, 2009)
" penicillin (PEN) both combined with gentamicin in the empirical treatment of neonates at risk of early onset neonatal sepsis (EOS)."	9.14	Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis. ( Ilmoja, ML; Lutsar, I; Maipuu, L; Merila, M; Metsvaht, T; Parm, Ü, 2010)
"40 seriously ill patients with complicated urinary tract infections were randomly assigned to receive either a single daily dose of ceftriaxone or combined therapy with cefazolin and gentamicin administered every 8 hours."	9.06	[Ceftriaxone or combined cefazolin-gentamicin for complicated urinary tract infections]. ( Feld, S; Krupsky, M; Landau, Z, 1990)
"To compare the efficacy and safety of one dose per day compared to multiple doses per day of gentamicin in suspected or proven sepsis in neonates."	8.93	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Moon, K; Rao, SC; Srinivasjois, R, 2016)
"To compare the efficacy and safety of one dose per day compared to multiple doses per day of gentamicin in suspected or proven sepsis in neonates."	8.87	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Ahmed, M; Hagan, R; Rao, SC; Srinivasjois, R, 2011)
"Gentamicin is widely used in the treatment of suspected or proven neonatal sepsis."	8.83	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Ahmed, M; Hagan, R; Rao, SC, 2006)
"Based on in vitro susceptibilities and the concern for emergence of resistance and long-term safety, ampicillin plus gentamicin remains the recommended antibiotic regimen for early onset neonatal sepsis."	8.31	Ampicillin and Gentamicin Treatment for Early Onset Neonatal Sepsis: When One Size Does Not Fit All. ( Arrieta, A; Bhakta, K; Daniels, K; Morphew, T; Nieves, DJ; Osborne, S; Tran, MT, 2023)
"This retrospective observational study including patients with community-acquired sepsis or septic shock and positive blood cultures, who meet Sepsis-3 criteria, shows that the addition of one single dose of gentamicin to β-lactam treatment at admittance was associated with a decreased risk of mortality and was not associated with AKI."	7.96	Antibiotic treatment with one single dose of gentamicin at admittance in addition to a β-lactam antibiotic in the treatment of community-acquired bloodstream infection with sepsis. ( Fredlund, H; Källman, J; Liljedahl Prytz, K; Magnuson, A; Prag, M; Sundqvist, M, 2020)
"To achieve an optimal effect in patients with sepsis at the emergency department (ED), the gentamicin peak-concentration should be sufficiently high (i."	7.91	Improving peak concentrations of a single dose regime of gentamicin in patients with sepsis in the emergency department. ( Cobussen, M; Haeseker, MB; Havenith, T; Posthouwer, D; Savelkoul, PHM; Stassen, PM; van Tiel, FH, 2019)
"Short-course empirical gentamicin use in patients with sepsis was associated with an increased incidence of renal failure but not with faster reversal of shock or improved survival in a setting with low prevalence of antimicrobial resistance."	7.85	Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study. ( Bonten, MJM; Cremer, OL; Frencken, JF; Juffermans, N; Klein Klouwenberg, PMC; Ong, DSY; van der Poll, T, 2017)
"The aim of this study was to describe the population pharmacokinetics (PK) of gentamicin in neonates with suspected or proven Gram-negative sepsis and determine the optimal dosage regimen in relation to the bacterial MICs found in this population."	7.85	Population Pharmacokinetics and Dosing Considerations for Gentamicin in Newborns with Suspected or Proven Sepsis Caused by Gram-Negative Bacteria. ( Bijleveld, YA; de Haan, TR; Hodiamont, CJ; Mathôt, RA; van den Heuvel, ME, 2017)
"Sixty-three ICU patients (Simplified Acute Physiology Score II = 43 ± 16) with severe sepsis and an indication for intravenous amikacin (n = 47) or gentamicin (n = 16) were included."	7.83	Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis. ( Allaouchiche, B; Evrard, A; Friggeri, A; Knani, H; Lavigne, JP; Lefrant, JY; Louart, B; Muller, L; Nucci, B; Roberts, JA; Roger, C, 2016)
"Previous studies have shown that the high dose of gentamicin (8 mg/kg) rarely achieves the desired peak plasma concentration (Cmax) of ≥30 mg/l in patients with severe sepsis or septic shock."	7.83	A study to evaluate the first dose of gentamicin needed to achieve a peak plasma concentration of 30 mg/l in patients hospitalized for severe sepsis. ( Allou, N; Allyn, J; Augustin, P; Charifou, Y; Corradi, L; Galas, T; Martinet, O; Valance, D; Vandroux, D, 2016)
"Gentamicin reduced the mortality from sepsis caused by this K."	7.81	Gentamicin therapy for sepsis due to carbapenem-resistant and colistin-resistant Klebsiella pneumoniae. ( Gonzalez-Padilla, M; López-Cerero, L; Natera, C; Pascual, A; Pontes-Moreno, A; Rivera-Espinar, F; Rivero, A; Rodríguez, M; Rodríguez-Baño, J; Rodríguez-López, F; Salcedo, I; Torre-Cisneros, J, 2015)
" The majority of NICU admissions receive potentially ototoxic aminoglycoside therapy, such as gentamicin, for presumed sepsis."	7.81	Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure. ( Cross, CP; Garinis, AC; Liao, S; Srikanth, P; Steyger, PS; Urdang, ZD, 2015)
"To determine the safety of gentamicin when used in a community setting to treat neonatal sepsis."	7.79	Risk of hearing loss in children exposed to gentamicin for the treatment of sepsis in young infancy: a community based cohort study in Pakistan. ( Ali, SA; Azam, I; Iftikhar, U; Saleem, S; Tikmani, SS; Zaidi, AK, 2013)
"We changed from ampicillin and gentamicin (AG) to piperacillin-tazobactam (PT) for routine treatment of suspected early-onset sepsis."	7.79	Results of a two-center, before and after study of piperacillin-tazobactam versus ampicillin and gentamicin as empiric therapy for suspected sepsis at birth in neonates ≤ 1500 g. ( Bloom, BT; Chong, E; Delmore, P; Forur, L; Gordon, P; Reynolds, J; Shaw, J; Uner, H, 2013)
"Explore feasibility and acceptability of gentamicin in the Uniject prefilled injection system, in combination with oral cotrimoxazole-p and an appropriate newborn weighing scale, for treatment of possible neonatal sepsis when administered in the community by female community health volunteers."	7.78	Feasibility and acceptability of gentamicin in the Uniject prefilled injection system for community-based treatment of possible neonatal sepsis: the experience of female community health volunteers in Nepal. ( Coffey, PS; Dawson, P; Gargi, KC; Neupane, D; Pradhan, YV; Sharma, J, 2012)
" This study investigated the epidemiological, microbiological, and prognostic characteristics of high-level gentamicin-resistant (HLGR) enterococcal bacteremia, including severe cases of infective endocarditis, in Japan."	7.78	A surveillance of high-level gentamicin-resistant enterococcal bacteremia. ( Araoka, H; Kimura, M; Yoneyama, A, 2012)
"Relative to the cefotaxime-gentamicin combination, the moxifloxacin-cefotaxime combination significantly reduced microglial activation and immature oligodendrocyte cell death and delayed myelination in the developing white matter of neonatal rats with experimental Escherichia coli sepsis."	7.77	Effect of moxifloxacin combined with cefotaxime compared to cefotaxime-gentamicin combination on prevention of white matter damage associated with Escherichia coli sepsis in neonatal rats. ( Baud, O; Bidet, P; Bingen, E; Biran, V; Bonacorsi, S; Brunel-Meunier, N; Charriaut-Marlangue, C; Gressens, P; Kitzis, MD; Le Saché, N; Pansiot, J; Pham, H, 2011)
"To evaluate two different regimens for gentamicin administration (once or twice daily) in newborns with suspected sepsis, and the ability of these regimens to achieve recommended serum gentamicin concentrations (SGC) within the therapeutic range."	7.75	Pharmacological differences between once daily and twice daily gentamicin dosage in newborns with suspected sepsis. ( Hagen, I; Øymar, K, 2009)
"To investigate the effect of sepsis upon the volume of distribution (Vd) of gentamicin in neonates."	7.73	The effect of sepsis upon gentamicin pharmacokinetics in neonates. ( Broadbent, R; Lingvall, M; Reith, D, 2005)
") gentamicin in African infants with suspected severe sepsis."	7.72	Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected severe sepsis in Kenya. ( Edwards, G; English, M; Kokwaro, GO; Mohammed, S; Muchohi, SN; Thomson, AH, 2003)
"A retrospective evaluation of serum concentration monitoring of aminoglycosides (gentamicin and amikacin) and vancomycin in neonates treated for sepsis in a maternity and children hospital in Jeddah, Saudi Arabia, over the period 1998-2000."	7.72	Aminoglycoside and vancomycin serum concentration monitoring and mortality due to neonatal sepsis in Saudi Arabia. ( Al Hammadi, AY; El Desoky, ES; Sheikh, AA, 2003)
"29 patients with serious renal or urinary tract infections were treated with netilmicin (initial dose 1."	7.66	Netilmicin therapy of serious renal and urinary tract infections in patients with normal and impaired renal function. ( Denneberg, T; Haeger, K; Juhlin, I, 1980)
"To compare the in vitro activity of cefamandole with ampicillin, cefoxitin, and gentamicin, each antimicrobial was tested against 419 bacteria isolated from the blood of patients with proved sepsis."	7.66	Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis. ( Mirrett, S; Reller, LB, 1980)
"Thirty-one patients with severe gram-negative bacterial infections were treated successfully with a combination of cefamandole nafate plus gentamicin or tobramycin."	7.66	Efficacy and safety of cefamandole plus either gentamicin or tobramycin in therapy of severe gram-negative bacterial infections. ( Gentry, LO, 1978)
"Thirty-eight adult patients with serious pleuropulmonary, soft-tissue, bone, and intra-abdominal infections caused by combinations of aerobic, facultative, and anaerobic bacteria were treated with parenterally given clindamycin phosphate and gentamicin sulfate and surgery when appropriate."	7.65	Clindamycin and gentamicin for aerobic and anaerobic sepsis. ( Fass, RJ; Gardner, WG; Rotilie, CA; Ruiz, DE, 1977)
"This paper reports our experience in monitoring gentamicin therapy during the treatment of 68 episodes of serious Gram-negative sepsis in 65 hospital patients."	7.65	Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis. ( Garfield-Davies, D; Hughes, K; Noone, P; Parsons, TM; Pattison, JR; Slack, RC, 1974)
" Renal dysfunction is significantly more frequent in cirrhotic patients treated with netilmicin but with careful attention to dosage and fluid management the clinical effect is likely to be relatively modest."	6.68	A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients. ( Burroughs, AK; Chin, JK; Greenslade, L; Kibbler, CC; McCormick, PA; McIntyre, N, 1997)
"Sepsis and septic shock are common cause of hospitalisation in intensive care unit."	6.48	[An effect of continuous and intermittent renal replacement therapy on antibiotic treatment in critically ill patients with sepsis - a practice-based perspective of vancomycin and gentamycin therapies]. ( Duricová, J; Grundmann, M; Kacířová, I; Martínek, A; Petejová, N; Plášek, J; Valkovský, I; Zahálková, J, 2012)
" >24 hours) dosing may be applicable to neonates."	6.44	Extended-interval dosing of gentamicin for treatment of neonatal sepsis in developed and developing countries. ( Batra, M; Darmstadt, GL; Law, K; Law, P; Miller-Bell, M, 2008)
"120 neonates aged ≤28 days admitted being treated with standard-of-care (SOC) antibiotics for sepsis: ampicillin and gentamicin between March 2018 and February 2019."	5.51	Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload. ( Berkley, JA; Correia, E; Egondi, T; Ellis, S; Gastine, S; Kane, Z; Kipper, K; Murunga, S; Nyaoke, B; Obiero, CW; Omollo, R; Sharland, M; Standing, JF; Thitiri, J; Walker, AS; Williams, P, 2022)
"This study aimed to simultaneously investigate the pharmacokinetics of ampicillin and gentamicin, currently the WHO standard of care for treating neonatal sepsis."	5.51	Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis. ( Berkley, JA; Correia, E; Ellis, S; Gastine, S; Kane, Z; Kipper, K; Murunga, S; Nyaoke, B; Obiero, C; Readman, J; Sharland, M; Standing, JF; Thitiri, J; van den Anker, J; Williams, P, 2022)
"Mean gentamicin dose was 4."	5.43	No increased risk of acute kidney injury after a single dose of gentamicin in patients with sepsis. ( Cobussen, M; de Kort, JM; Dennert, RM; Lowe, SH; Stassen, PM, 2016)
"Neonatal sepsis is a significant cause of morbidity and mortality among term and preterm infants."	5.39	Gentamicin resistance among Escherichia coli strains isolated in neonatal sepsis. ( Attar, M; Bradford, L; Harrison, C; Hasvold, J; Nelson, C; Stillwell, T, 2013)
" In the LPSIL+GE group relative to C+GE, the half-life (t(1/2)) was 79% higher (p<0."	5.38	A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2. ( Chládek, J; Krs, O; Martinkova, J; Senkerik, M; Slizova, D; Springer, D; Studena, S, 2012)
"The primary objective was to determine if initial empirical intravenous dosing of gentamicin improved patient's outcomes in pyelonephritis/urosepsis compared with alternative IV antibiotic management."	5.30	The use of initial dosing of gentamicin in the management of pyelonephritis/urosepsis: A retrospective study. ( Czarniak, P; Parsons, R; Ryanto, S; Skinner, M; Sunderland, B; Travers, K; Wong, M, 2019)
"Ampicillin resistance was mainly found in very low and low birthweight infants with late-onset infections, in which aerobic Gram-negative rods were common pathogens."	5.28	Ampicillin-aminoglycoside combinations as initial treatment for neonatal septicaemia or meningitis. A retrospective evaluation of 12 years' experience. ( Larsson, P; Tessin, I; Thiringer, K; Trollfors, B, 1991)
"The impact of the dosage schedule on the therapeutic efficacy of antibiotics was investigated in experimental Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats."	5.28	Impact of the dosage schedule on the efficacy of ceftazidime, gentamicin and ciprofloxacin in Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats. ( Bakker-Woudenberg, IA; Michel, BM; Roosendaal, R; van den Berghe-van Raffe, M; Vink-van den Berg, JC, 1989)
" coli and should be used in combination with ampicillin to achieve an outcome comparable to that of gentamicin in this model of E."	5.27	Comparison of gentamicin and kanamycin alone and in combination with ampicillin in experimental Escherichia coli bacteremia and meningitis. ( Kim, KS, 1985)
"Gentamicin was administered at 7."	5.25	Kanamycin and gentamicin treatment of neonatal sepsis and meningitis. ( Anderson, DC; Chang, MJ; Escobedo, M; Feigin, RD; Hillman, L, 1975)
"Gentamicin and the other aminoglycosides are toxic antibiotics, but they are urgently needed to treat newborns with neonatal sepsis."	5.17	Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. ( Dwijayanti, A; Louisa, M; Rundjan, L; Setiabudy, R; Simanjuntak, E; Suwento, R; Yasin, FH, 2013)
"Extended-interval dosing of gentamicin has several advantages over conventional multiple-daily dosing for the treatment of sepsis."	5.14	Simplified dosing of gentamicin for treatment of sepsis in Bangladeshi neonates. ( Aranda, J; Chowdhury, NA; Coffey, P; Darmstadt, GL; Edwards, D; Hossain, MM; Miller-Bell, M; Saha, SK; Shirin, M, 2009)
" penicillin (PEN) both combined with gentamicin in the empirical treatment of neonates at risk of early onset neonatal sepsis (EOS)."	5.14	Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis. ( Ilmoja, ML; Lutsar, I; Maipuu, L; Merila, M; Metsvaht, T; Parm, Ü, 2010)
"In an open, randomised, controlled trial, infants with suspected severe sepsis admitted to a Kenyan, rural district hospital received a novel, OD gentamicin regimen or routine multi-dose (MD) regimens."	5.11	A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants. ( English, M; Kokwaro, G; Marsh, K; Mohammed, S; Ndirangu, S; Ross, A; Shann, F, 2004)
"The practice of locking newly inserted tunneled central venous catheters with gentamicin and heparin is an effective strategy to reduce line sepsis rates, and is associated with beneficial effects on epoetin requirements."	5.11	Locking of tunneled hemodialysis catheters with gentamicin and heparin. ( Fluck, RJ; Hulme, LJ; McIntyre, CW; Taal, M, 2004)
"Gentamicin peak and trough serum concentrations were collected from 139 neonates divided into three groups who were receiving one of the following intravenous 24-hour gentamicin regimens during the first 10 days of life, based on gestational age and birth weight (group 1, < 28 wks, 2."	5.10	A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates. ( Cole, C; DiCenzo, R; Forrest, A; Guillet, R; Slish, JC, 2003)
"Fifty full term infants with birth weight of >/=2500 gm admitted to the neonatal intensive care unit of King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia between November 1999 to October 2000 and received gentamicin at a dose of 2."	5.10	Once daily gentamicin dosing in full term neonates. ( Alsaedi, SA, 2003)
"Fifty-eight very low birth weight infants (600 to 1500 g), prescribed gentamicin for treatment of suspected sepsis during the first week after birth, were randomized to receive either the new dosing schedule [every 48 h (q48h)] or the existing dosing schedule [every 24 h (q24h)]."	5.10	Comparison of two gentamicin dosing schedules in very low birth weight infants. ( Agarwal, G; Pildes, RS; Pyati, S; Rastogi, A, 2002)
"To compare performance and cost analysis of two gentamicin regimens in infants >/=34 weeks' gestation requiring antibiotics for a 72-hour rule-out sepsis evaluation."	5.09	Once- versus twice-daily gentamicin dosing in neonates >/=34 Weeks' gestation: cost-effectiveness analyses. ( Gresores, A; Hall, DM; Kawato, K; Reiter, PD; Stolpman, NM; Thureen, PJ, 1999)
"Two similar cohorts of low birth weight infants whose size was appropriate for gestational age randomly received either aztreonam-arginine plus ampicillin (n = 15) or gentamicin plus ampicillin (n = 15) for empiric treatment of neonatal sepsis."	5.07	Metabolic tolerance to arginine: implications for the safe use of arginine salt-aztreonam combination in the neonatal period. ( Argyle, C; McCracken, G; Mize, C; Uauy, R, 1991)
"40 seriously ill patients with complicated urinary tract infections were randomly assigned to receive either a single daily dose of ceftriaxone or combined therapy with cefazolin and gentamicin administered every 8 hours."	5.06	[Ceftriaxone or combined cefazolin-gentamicin for complicated urinary tract infections]. ( Feld, S; Krupsky, M; Landau, Z, 1990)
"To assess the efficacy of single-agent therapy relative to standard combination antibiotic therapy for the initial management of fever and neutropenia in cancer patients, we conducted a randomized trial comparing ceftazidime alone with a combination of cephalothin, gentamicin, and carbenicillin."	5.06	A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. ( Browne, M; Commers, J; Cotton, D; Gress, J; Hathorn, JW; Hiemenz, J; Longo, D; Marshall, D; McKnight, J; Pizzo, PA, 1986)
"Thirty-six patients with severe aplastic anemia or acute leukemia undergoing bone marrow transplantation or intensive hematologic treatments were randomized to receive gentamicin (1 mg/kg/iv q8h) or tobramycin (1 mg/kg/iv q8h) in combination with carbenecillin (500 mg/kg/day i."	5.05	Tobramycin versus gentamicin, in combination with cephalotin and carbenecillin, in patients undergoing bone marrow transplantation. ( Bacigalupo, A; Frassoni, F; Grazi, G; Marmont, A; Podestà, M; Soro, O; Van Lint, MT; Volta, C, 1981)
"Background Guidelines from 2005 for treating suspected sepsis in low- and middle-income countries (LMIC) recommended hospitalisation and prophylactic intramuscular (IM) or intravenous (IV) ampicillin and gentamicin."	4.98	Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children. ( Bielicki, J; Fuchs, A; Mathur, S; Sharland, M; Van Den Anker, JN, 2018)
"To compare the efficacy and safety of one dose per day compared to multiple doses per day of gentamicin in suspected or proven sepsis in neonates."	4.93	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Moon, K; Rao, SC; Srinivasjois, R, 2016)
"To compare the efficacy and safety of one dose per day compared to multiple doses per day of gentamicin in suspected or proven sepsis in neonates."	4.87	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Ahmed, M; Hagan, R; Rao, SC; Srinivasjois, R, 2011)
" Investigators have explored the potential therapeutic role of anti-oxidants in both experimental animal models and human studies of AKI in several clinical settings, including cardiac and aortic occlusive surgeries, sepsis, drug nephrotoxicity (cisplatin and gentamicin), as well as rhabdomyolysis."	4.84	Antioxidants. Do they have a place in the prevention or therapy of acute kidney injury? ( Koyner, JL; Murray, PT; Sher Ali, R, 2008)
"Gentamicin is widely used in the treatment of suspected or proven neonatal sepsis."	4.83	One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. ( Ahmed, M; Hagan, R; Rao, SC, 2006)
"Based on in vitro susceptibilities and the concern for emergence of resistance and long-term safety, ampicillin plus gentamicin remains the recommended antibiotic regimen for early onset neonatal sepsis."	4.31	Ampicillin and Gentamicin Treatment for Early Onset Neonatal Sepsis: When One Size Does Not Fit All. ( Arrieta, A; Bhakta, K; Daniels, K; Morphew, T; Nieves, DJ; Osborne, S; Tran, MT, 2023)
" According to our department protocol, women with isolated intrapartum fever received intravenous ampicillin, whereas women with clinical chorioamnionitis received intravenous ampicillin plus gentamicin."	4.31	Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes. ( Abu Shqara, R; Frank Wolf, M; Glikman, D; Jad, S; Lowenstein, L; Rechnitzer, H, 2023)
" The aims of this study were to track the 7-day time course of blood miRNAs in patients with sepsis treated with vancomycin, gentamicin, or a non-nephrotoxic antibiotic and miRNA associations with neutrophil gelatinase-associated lipokalin (NGAL), creatinine, procalcitonin, interleukin-6, and acute kidney injury (AKI) stage."	4.12	Expression and 7-day time course of circulating microRNAs in septic patients treated with nephrotoxic antibiotic agents. ( Bace, E; Bris, R; Kacirova, I; Kanova, M; Klementa, V; Martinek, A; Petejova, N; Pribylova, L; Sigutova, R; Stejskal, D; Svagera, Z; Zadrazil, J, 2022)
"Increasing studies have reported that gentamicin (GNT) plays an essential role in sepsis; however, its underlying mechanism is still unclear."	4.12	Gentamicin promoted the production of CD4 ( Li, J; Li, N; Li, S; Xie, M; Xu, F, 2022)
"Rectal swab cultures identify patients with ciprofloxacin-resistant rectal flora who have an eight-fold risk of sepsis."	3.96	Effect of Augmented Antimicrobial Prophylaxis and Rectal Swab Culture-guided Targeted Prophylaxis on the Risk of Sepsis Following Transrectal Prostate Biopsy. ( Dall'Antonia, M; Eragat, M; Hadjipavlou, M; Hammadeh, MY; Kenny, C; Mulhem, W; Pantelidou, M; Wood, C, 2020)
"This retrospective observational study including patients with community-acquired sepsis or septic shock and positive blood cultures, who meet Sepsis-3 criteria, shows that the addition of one single dose of gentamicin to β-lactam treatment at admittance was associated with a decreased risk of mortality and was not associated with AKI."	3.96	Antibiotic treatment with one single dose of gentamicin at admittance in addition to a β-lactam antibiotic in the treatment of community-acquired bloodstream infection with sepsis. ( Fredlund, H; Källman, J; Liljedahl Prytz, K; Magnuson, A; Prag, M; Sundqvist, M, 2020)
"To achieve an optimal effect in patients with sepsis at the emergency department (ED), the gentamicin peak-concentration should be sufficiently high (i."	3.91	Improving peak concentrations of a single dose regime of gentamicin in patients with sepsis in the emergency department. ( Cobussen, M; Haeseker, MB; Havenith, T; Posthouwer, D; Savelkoul, PHM; Stassen, PM; van Tiel, FH, 2019)
"There was a significant reduction in the incidence of sepsis after prostate biopsy using a combination of a ciprofloxacin-ceftriaxone antibiotic regimen and isopropyl alcohol needle washing."	3.88	Reduced Risk of Sepsis after Prostate Biopsy Using a Cephalosporin-Fluoroquinolone Antibiotic Regimen and Isopropyl Alcohol Needle Washing. ( Johnson-Mitchell, M; Neeb, AD; Simmons, MN, 2018)
"Short-course empirical gentamicin use in patients with sepsis was associated with an increased incidence of renal failure but not with faster reversal of shock or improved survival in a setting with low prevalence of antimicrobial resistance."	3.85	Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study. ( Bonten, MJM; Cremer, OL; Frencken, JF; Juffermans, N; Klein Klouwenberg, PMC; Ong, DSY; van der Poll, T, 2017)
"Extended-interval dosing (EID) regimens of gentamicin have been validated for treating confirmed or suspected early- and late-onset sepsis in preterm infants in the first week of life."	3.85	Extended-interval Dosing of Gentamicin in Premature Neonates Born at <32 Weeks' Gestation and >7 Days of age. ( Akierman, AR; Alshaikh, B; Dersch-Mills, D; Dobry, J; Sundaram, A; Yusuf, K, 2017)
"The aim of this study was to describe the population pharmacokinetics (PK) of gentamicin in neonates with suspected or proven Gram-negative sepsis and determine the optimal dosage regimen in relation to the bacterial MICs found in this population."	3.85	Population Pharmacokinetics and Dosing Considerations for Gentamicin in Newborns with Suspected or Proven Sepsis Caused by Gram-Negative Bacteria. ( Bijleveld, YA; de Haan, TR; Hodiamont, CJ; Mathôt, RA; van den Heuvel, ME, 2017)
"Sixty-three ICU patients (Simplified Acute Physiology Score II = 43 ± 16) with severe sepsis and an indication for intravenous amikacin (n = 47) or gentamicin (n = 16) were included."	3.83	Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis. ( Allaouchiche, B; Evrard, A; Friggeri, A; Knani, H; Lavigne, JP; Lefrant, JY; Louart, B; Muller, L; Nucci, B; Roberts, JA; Roger, C, 2016)
" Neonates admitted to a level II neonatal nursery diagnosed with (suspected) early-onset sepsis and commencing intravenous gentamicin therapy of 5 mg·kg every 36 hours were eligible for inclusion."	3.83	Extended-Interval Dosing of Gentamicin Aiming for a Drug-Free Period in Neonates: A Prospective Cohort Study. ( Sprij, A; Touw, DJ; van Maarseveen, EM, 2016)
" Empiric antibiotic therapy for sepsis was started with amoxicillin/clavulanate and gentamicin."	3.83	An 86-year-old man with acute abdominal pain. ( Posthouwer, D; van Dam, PM, 2016)
"Neonates with suspected or proven sepsis are treated with ampicillin and until recently with 5 mg gentamicin/kg every 24 h."	3.83	[Two cases of neonatal meningitis after new gentamicin dosing guidelines]. ( Blaabjerg, AS; Fenger-Grøn, J; Kofoed, PE; Møller, JK, 2016)
"Previous studies have shown that the high dose of gentamicin (8 mg/kg) rarely achieves the desired peak plasma concentration (Cmax) of ≥30 mg/l in patients with severe sepsis or septic shock."	3.83	A study to evaluate the first dose of gentamicin needed to achieve a peak plasma concentration of 30 mg/l in patients hospitalized for severe sepsis. ( Allou, N; Allyn, J; Augustin, P; Charifou, Y; Corradi, L; Galas, T; Martinet, O; Valance, D; Vandroux, D, 2016)
"Gentamicin is a common antibiotic used to treat sepsis in neonates."	3.83	Should gentamicin trough levels be routinely obtained in term neonates? ( El-Chaar, G; Hanna, N; Ibrahim, J; Islam, S; Maffei, D; Nayak, A; Ponnaiya, S; Rosenfeld, W, 2016)
"Gentamicin reduced the mortality from sepsis caused by this K."	3.81	Gentamicin therapy for sepsis due to carbapenem-resistant and colistin-resistant Klebsiella pneumoniae. ( Gonzalez-Padilla, M; López-Cerero, L; Natera, C; Pascual, A; Pontes-Moreno, A; Rivera-Espinar, F; Rivero, A; Rodríguez, M; Rodríguez-Baño, J; Rodríguez-López, F; Salcedo, I; Torre-Cisneros, J, 2015)
"A patient with leg cellulitis and sepsis received a single dose of gentamicin and a sample was sent for gentamicin analysis."	3.81	Paraprotein interference with turbidimetric gentamicin assay. ( Bassett, K; Brown, N; Dimeski, G, 2015)
" The majority of NICU admissions receive potentially ototoxic aminoglycoside therapy, such as gentamicin, for presumed sepsis."	3.81	Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure. ( Cross, CP; Garinis, AC; Liao, S; Srikanth, P; Steyger, PS; Urdang, ZD, 2015)
" Thus, on suspicion of sepsis, empiric antibiotic treatment combining piperacillin, oxacillin and gentamicin can be proposed until identification of the causative microorganism is available."	3.80	Epidemiological and bacteriological profiles in children with burns. ( Ben Khalifa, S; Daiki, M; Fekih Hassen, A, 2014)
"To determine the safety of gentamicin when used in a community setting to treat neonatal sepsis."	3.79	Risk of hearing loss in children exposed to gentamicin for the treatment of sepsis in young infancy: a community based cohort study in Pakistan. ( Ali, SA; Azam, I; Iftikhar, U; Saleem, S; Tikmani, SS; Zaidi, AK, 2013)
"We changed from ampicillin and gentamicin (AG) to piperacillin-tazobactam (PT) for routine treatment of suspected early-onset sepsis."	3.79	Results of a two-center, before and after study of piperacillin-tazobactam versus ampicillin and gentamicin as empiric therapy for suspected sepsis at birth in neonates ≤ 1500 g. ( Bloom, BT; Chong, E; Delmore, P; Forur, L; Gordon, P; Reynolds, J; Shaw, J; Uner, H, 2013)
"Explore feasibility and acceptability of gentamicin in the Uniject prefilled injection system, in combination with oral cotrimoxazole-p and an appropriate newborn weighing scale, for treatment of possible neonatal sepsis when administered in the community by female community health volunteers."	3.78	Feasibility and acceptability of gentamicin in the Uniject prefilled injection system for community-based treatment of possible neonatal sepsis: the experience of female community health volunteers in Nepal. ( Coffey, PS; Dawson, P; Gargi, KC; Neupane, D; Pradhan, YV; Sharma, J, 2012)
"Current dosing recommendations for administration of gentamicin to septic patients with acute kidney injury (AKI) on continuous venovenous hemofiltration (CVVH) at a filtration rate of 45 ml/kg/h are missing."	3.78	Gentamicin pharmacokinetics during continuous venovenous hemofiltration in critically ill septic patients. ( Brozmanova, H; Duricova, J; Grundmann, M; Kacirova, I; Martinek, A; Petejova, N; Urbanek, K; Zahalkova, J, 2012)
"Term neonates with unrepaired CHD who received gentamicin for empiric treatment of sepsis were identified over a 3-year period."	3.78	Use of 4-mg/kg/24-hour empiric aminoglycoside dosing in preoperative neonates with congenital heart disease. ( Moffett, BS; Rossano, JW, 2012)
" This study investigated the epidemiological, microbiological, and prognostic characteristics of high-level gentamicin-resistant (HLGR) enterococcal bacteremia, including severe cases of infective endocarditis, in Japan."	3.78	A surveillance of high-level gentamicin-resistant enterococcal bacteremia. ( Araoka, H; Kimura, M; Yoneyama, A, 2012)
"Relative to the cefotaxime-gentamicin combination, the moxifloxacin-cefotaxime combination significantly reduced microglial activation and immature oligodendrocyte cell death and delayed myelination in the developing white matter of neonatal rats with experimental Escherichia coli sepsis."	3.77	Effect of moxifloxacin combined with cefotaxime compared to cefotaxime-gentamicin combination on prevention of white matter damage associated with Escherichia coli sepsis in neonatal rats. ( Baud, O; Bidet, P; Bingen, E; Biran, V; Bonacorsi, S; Brunel-Meunier, N; Charriaut-Marlangue, C; Gressens, P; Kitzis, MD; Le Saché, N; Pansiot, J; Pham, H, 2011)
"Children with suspected sepsis were prospectively enrolled to receive ODD of gentamicin at 7 mg/kg/day."	3.77	Once-daily gentamicin in infants and children: a prospective cohort study evaluating safety and the role of therapeutic drug monitoring in minimizing toxicity. ( Best, EJ; Cohn, R; Gazarian, M; Palasanthiran, P; Wilkinson, M, 2011)
"These results support the use of gentamicin in the contrast medium injected into the biliary system as an ancillary method to prevent post-ERCP sepsis."	3.76	Addition of gentamicin to endoscopic retrograde cholangiopancreatography (ERCP) contrast medium towards reducing the frequency of septic complications of ERCP. ( Graham, DY; Osato, MS; Ramirez, FC; Woods, KL, 2010)
" The patients were treated with gentamicin for suspected sepsis, proven sepsis, or pneumonia as an early sign of sepsis."	3.76	Tolerability and outcomes of kinetically guided therapy with gentamicin in critically ill neonates during the first week of life: an open-label, prospective study. ( Chládek, J; Chládková, J; Martínková, J; Pokorná, P; Selke-Krulichová, I; Vobruba, V; Záhora, J, 2010)
"To evaluate two different regimens for gentamicin administration (once or twice daily) in newborns with suspected sepsis, and the ability of these regimens to achieve recommended serum gentamicin concentrations (SGC) within the therapeutic range."	3.75	Pharmacological differences between once daily and twice daily gentamicin dosage in newborns with suspected sepsis. ( Hagen, I; Øymar, K, 2009)
"Neonates >or=32 weeks of gestation and gentamicin for presumed sepsis."	3.75	Once daily dose gentamicin in neonates - is our dosing correct? ( Cooke, J; Khanna, G; McGregor-Colman, E; Penford, G; Serane, TV; Zengeya, S, 2009)
"Sepsis has been reported to increase the volume of distribution of gentamicin in neonates."	3.75	Evaluation of the effect of intravenous volume expanders upon the volume of distribution of gentamicin in septic neonates. ( Broadbent, RS; Kostan, E; Medlicott, NJ; Reith, DM; Sherwin, CM, 2009)
" The purpose of this study was to determine safe, effective, simplified dosing regimens of gentamicin for treatment of neonatal sepsis in developing countries."	3.74	Determination of extended-interval gentamicin dosing for neonatal patients in developing countries. ( Aranda, J; Choi, Y; Coffey, P; Darmstadt, GL; Edwards, D; Hossain, MM; Jana, AK; Miller-Bell, M; Saha, SK; Sridhar, S; Thomas, N; Willis, J, 2007)
"Neonates aged < or = 7 days, who had received gentamicin for clinically suspected or high risk of sepsis and had no contraindication to gentamicin usage were enrolled."	3.74	Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates. ( Chotinaruemol, S; Juntarakana, S; Rojanasthien, N; Tantiprabha, W, 2007)
"To investigate the effect of sepsis upon the volume of distribution (Vd) of gentamicin in neonates."	3.73	The effect of sepsis upon gentamicin pharmacokinetics in neonates. ( Broadbent, R; Lingvall, M; Reith, D, 2005)
"Since gentamicin is one of the most commonly prescribed antibiotics for culture-proven or suspected sepsis in neonates, interest has increased in refining dosing regimens for improved efficacy and decreased toxicity."	3.73	Once-daily gentamicin dosing of 4 Mg/Kg/dose in neonates. ( Jirapradittha, J; Kiatchoosakun, P; Kosalaraksa, P; Taksaphan, S; Tassniyom, S, 2005)
") gentamicin in African infants with suspected severe sepsis."	3.72	Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected severe sepsis in Kenya. ( Edwards, G; English, M; Kokwaro, GO; Mohammed, S; Muchohi, SN; Thomson, AH, 2003)
"A retrospective evaluation of serum concentration monitoring of aminoglycosides (gentamicin and amikacin) and vancomycin in neonates treated for sepsis in a maternity and children hospital in Jeddah, Saudi Arabia, over the period 1998-2000."	3.72	Aminoglycoside and vancomycin serum concentration monitoring and mortality due to neonatal sepsis in Saudi Arabia. ( Al Hammadi, AY; El Desoky, ES; Sheikh, AA, 2003)
"It is our practice to treat suspected sepsis with imipenem/cilastatin and gentamicin (IMP/GENT) for 72 hours while awaiting culture results."	3.70	Empiric therapy of sepsis in the surgical intensive care unit with broad-spectrum antibiotics for 72 hours does not lead to the emergence of resistant bacteria. ( Ball, S; Civetta, JM; Harvill, S; McKenney, MG; Namias, N; Salomone, JP; Sleeman, D, 1998)
"This prospective, comparative study was designed to estimate the volume of distribution (Vd) and elimination rate constant (K(e)) of gentamicin and to determine the clinical factors affecting the pharmacokinetics of gentamicin in different stages of sepsis."	3.70	Factors affecting gentamicin pharmacokinetics in septic patients. ( Kong, CW; Lee, TY; Lin, BS; Tang, GJ; Tang, JJ, 1999)
"Currently recommended antibiotic treatment of suspected neonatal sepsis is ampicillin and an aminoglycoside."	3.70	Neonatal escherichia coli infections: concerns regarding resistance to current therapy. ( Friedman, S; Matlow, AG; Ohlsson, A; Shah, V, 2000)
"Almost 30 years after its introduction, gentamicin continues to play a key role in the treatment of gram negative sepsis."	3.69	Gentamicin once a day. ( MacConnachie, AM, 1996)
"To determine: (1) whether a lumbar puncture (LP) is indicated in asymptomatic full-term newborns delivered by mothers at risk of intrapartum sepsis; and (2) whether gentamicin improves bacterial coverage for such newborns when used with ampicillin."	3.69	Term newborns who are at risk for sepsis: are lumbar punctures necessary? ( Johnson, CE; Pethe, K; Saxena, K; Super, DM; Whitwell, JK, 1997)
"Gentamicin intrapatient pharmacokinetics variations were studied in 40 critically ill medical patients, suffering gram-negative sepsis."	3.68	Gentamicin volume of distribution in critically ill septic patients. ( Benito, S; Fernández, R; Izquierdo, I; Net, A; Rello, J; Torrent, J; Triginer, C, 1990)
"Pyogenic meningitis became apparent on the third day of ampicillin and gentamicin therapy for Aeromonas hydrophila sepsis in a patient with severe alcoholic hepatitis."	3.67	Pyogenic meningitis manifesting during therapy for Aeromonas hydrophila sepsis. ( Ellison, RT; Mostow, SR, 1984)
"The nephrotoxicity of gentamicin and amikacin was compared during presumed sepsis in 107 premature neonates."	3.67	Aminoglycoside-related nephrotoxicity in the premature newborn. ( Good, F; Harding, E; Klein, J; MacLeod, S; Perlman, M; Prober, CG; Rajchgot, P; Soldin, S, 1984)
" One group of animals (n = 9) received gentamicin 2 mg/kg intravenously infusion two hours after induction of sepsis with live E."	3.67	Increased plasma levels of endotoxin and corresponding changes in circulatory performance in a porcine sepsis model: the effect of antibiotic administration. ( Giercksky, KE; Osterud, B; Revhaug, A; Røkke, O, 1988)
"In an effort to develop more effective antimicrobial therapy, we evaluated three alternative regimens currently available to clinicians for their efficacy against experimental bacteremia and meningitis due to group B Streptococcus (GBS) in newborn rats: various doses of penicillin G (100, 200, 400, or 800 mg/kg per day), combined penicillin G-gentamicin vs."	3.67	Effect of antimicrobial therapy for experimental infections due to group B Streptococcus on mortality and clearance of bacteria. ( Kim, KS, 1987)
"To evaluate the role of antibiotic class in the rate of liberation of endotoxin during therapy for sepsis caused by gram-negative bacteria, we obtained serial blood samples from rabbits with sepsis caused by Escherichia coli and treated with chloramphenicol, gentamicin, or moxalactam."	3.67	Role of antibiotic class in the rate of liberation of endotoxin during therapy for experimental gram-negative bacterial sepsis. ( Barton, RP; Mogan, KA; Shenep, JL, 1985)
" For the elderly patient with acute symptomatic bacterial pyelonephritis caused by gram-negative aerobic bacilli, an aminoglycoside is recommended, eg, gentamicin, tobramycin, or amikacin."	3.67	Diagnosing a common kidney infection of the elderly inpatient. ( Gleckman, RA, 1985)
"29 patients with serious renal or urinary tract infections were treated with netilmicin (initial dose 1."	3.66	Netilmicin therapy of serious renal and urinary tract infections in patients with normal and impaired renal function. ( Denneberg, T; Haeger, K; Juhlin, I, 1980)
"Eleven premature neonates received gentamicin sulfate for treatment of suspected gram-negative sepsis with accompanying respiratory distress syndrome."	3.66	Two-compartment gentamicin pharmacokinetics in premature neonates: a comparison to adults with decreased glomerular filtration rates. ( Grassi, A; Haughey, DB; Hilligoss, DM; Schentag, JJ, 1980)
"Presented are blood culture results obtained from 200 patients with post-cesarean section endomyometritis treated with either penicillin-gentamicin or clindamycin-gentamicin."	3.66	Bacteremia in post-Cesarean section endomyometritis: differential response to therapy. ( DiZerega, GS; Keegan, K; Ledger, W; Nakamura, R; Roy, S; Yonekura, ML, 1980)
"A 39-year-old woman who developed acute renal failure following intra-abdominal sepsis was treated with gentamicin."	3.66	Gentamicin extraction from an anuric patient by combined haemodialysis and charcoal haemoperfusion. ( Bhamjee, A; Wright, N, 1980)
"To compare the in vitro activity of cefamandole with ampicillin, cefoxitin, and gentamicin, each antimicrobial was tested against 419 bacteria isolated from the blood of patients with proved sepsis."	3.66	Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis. ( Mirrett, S; Reller, LB, 1980)
"Thirty-one patients with severe gram-negative bacterial infections were treated successfully with a combination of cefamandole nafate plus gentamicin or tobramycin."	3.66	Efficacy and safety of cefamandole plus either gentamicin or tobramycin in therapy of severe gram-negative bacterial infections. ( Gentry, LO, 1978)
"Gentamicin (GM) was intramuscularly injected to 16 children with various infectious disease (1 septicemia, 1 purulent meningitis, 4 bronchopneumonia, 1 pyothorax, 3 pyelonephritis, 2 acute cystitis and 4 RITTER'S dermatitis)."	3.65	[Further study on gentamicin in pediatrics (author's transl)]. ( Fujii, S; Hirama, Y; Nakazawa, S; Sato, H; Watanabe, O, 1976)
"Thirty-eight adult patients with serious pleuropulmonary, soft-tissue, bone, and intra-abdominal infections caused by combinations of aerobic, facultative, and anaerobic bacteria were treated with parenterally given clindamycin phosphate and gentamicin sulfate and surgery when appropriate."	3.65	Clindamycin and gentamicin for aerobic and anaerobic sepsis. ( Fass, RJ; Gardner, WG; Rotilie, CA; Ruiz, DE, 1977)
" The patient was believed to have Pseudomonas bronchitis and was given parenteral gentamicin."	3.65	Failure of a "prophylactic" antimicrobial drug to prevent sepsis after fiberoptic bronchoscopy. ( Goldman, AL; Robbins, H, 1977)
" in cases of abdominal and puerperal sepsis necessitates addition of a lincomycin or metronidazole."	3.65	Septicaemia. ( , 1975)
"This paper reports our experience in monitoring gentamicin therapy during the treatment of 68 episodes of serious Gram-negative sepsis in 65 hospital patients."	3.65	Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis. ( Garfield-Davies, D; Hughes, K; Noone, P; Parsons, TM; Pattison, JR; Slack, RC, 1974)
"Neonatal sepsis is a serious condition, where an adequate empiric antibiotic treatment is crucial."	2.82	Efficacy of empiric antibiotic treatment of late-onset neonatal sepsis caused by Enterobacteriaceae: A systematic review. ( Akselsen, AB; Sheth, CC; Veses, V, 2022)
"Cloxacillin + Amikacin were administered to 40 and Cefotaxime + Gentamicin to 50 babies."	2.79	Comparison of two empiric antibiotic regimen in late onset neonatal sepsis--a randomized controlled trial. ( Bethou, A; Biswal, N; Mathai, B; Ramasamy, S, 2014)
"Possible serious bacterial infection was diagnosed in 704 infants, among 5766 screened."	2.77	Community-based treatment of serious bacterial infections in newborns and young infants: a randomized controlled trial assessing three antibiotic regimens. ( Bhutta, ZA; Darmstadt, GL; Sultana, S; Thaver, D; Tikmani, SS; Warraich, HJ; Zaidi, AK, 2012)
" twice daily dosing (TDD) to establish the appropriate dosage for Thai neonates."	2.71	Once versus twice daily dose of gentamicin therapy in Thai neonates. ( Janthep, P; Jirapradittha, J; Kiatchoosakun, P; Kosalaraksa, P; Taksaphan, S, 2004)
"Treatment with gentamicin stabilized cardiac index (BL, 5."	2.71	Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. ( Enkhbaatar, P; Heggers, JP; Herndon, DN; Jodoin, JM; Maybauer, DM; Maybauer, MO; Morita, N; Traber, DL; Traber, LD; Westphal, M, 2005)
"To compare the efficacy of once daily gentamicin administration to the conventional twice daily dosage schedule by estimation of serum gentamicin concentrations (SGC) in neonates."	2.69	Randomized controlled trial of once vs. twice daily gentamicin therapy in newborn. ( Jana, AK; Jeyaseelan, L; Job, V; Kanagasabapathy, AS; Kuruvilla, KA; Selvakumar, R; Solomon, R, 1999)
" Renal dysfunction is significantly more frequent in cirrhotic patients treated with netilmicin but with careful attention to dosage and fluid management the clinical effect is likely to be relatively modest."	2.68	A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients. ( Burroughs, AK; Chin, JK; Greenslade, L; Kibbler, CC; McCormick, PA; McIntyre, N, 1997)
"Acute kidney injury is a common complication in critically ill patients with sepsis and/or septic shock."	2.66	Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents-Pathophysiology and Biomarkers-A Review. ( Hrabovsky, V; Kacirova, I; Kanova, M; Klementa, V; Martinek, A; Petejova, N; Sigutova, R; Stejskal, D; Svagera, Z; Zadrazil, J, 2020)
" Using stepwise discriminant analysis, we selected these factors with liver dysfunction and the serum urea nitrogen:serum creatinine ratio in a function that accurately discriminates between toxic and nontoxic patients."	2.65	Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. ( Lietman, PS; Moore, RD; Smith, CR, 1984)
"The response rate for all infections was 97 per cent in group 1, 91 per cent in group 2 and 95 per cent in group 3."	2.65	Randomized trial of empiric antibiotic therapy with ticarcillin in combination with gentamicin, amikacin or netilmicin in febrile patients with granulocytopenia and cancer. ( Bender, JF; Fortner, CL; Hahn, DM; Love, LJ; Schimpff, SC; Standiford, HC; Wiernik, PH; Young, VM, 1979)
"Amikacin or gentamicin was used to treat 174 patients with suspected severe gram-negative infections in a prospective, randomized, double-blind trial."	2.64	Controlled comparison of amikacin and gentamicin. ( Baughman, KL; Edwards, CQ; Lietman, PS; Rogers, JF; Smith, CR, 1977)
"Chorioamnionitis is a common infection that affects both mother and infant."	2.50	Antibiotic regimens for management of intra-amniotic infection. ( Bonfill Cosp, X; Chapman, E; Illanes, E; Reveiz, L, 2014)
"Sepsis and septic shock are common cause of hospitalisation in intensive care unit."	2.48	[An effect of continuous and intermittent renal replacement therapy on antibiotic treatment in critically ill patients with sepsis - a practice-based perspective of vancomycin and gentamycin therapies]. ( Duricová, J; Grundmann, M; Kacířová, I; Martínek, A; Petejová, N; Plášek, J; Valkovský, I; Zahálková, J, 2012)
" >24 hours) dosing may be applicable to neonates."	2.44	Extended-interval dosing of gentamicin for treatment of neonatal sepsis in developed and developing countries. ( Batra, M; Darmstadt, GL; Law, K; Law, P; Miller-Bell, M, 2008)
"Neonatal sepsis is one of the major health problems throughout the world."	2.43	Neonatal sepsis-- a global problem: an overview. ( Afroza, S, 2006)
" This study aimed to optimize the dosing strategy of gentamicin in intermittently hemodialyzed patients by simulating concentration-time profiles during pre- and postdialysis dosing, based on a published pharmacokinetic model."	1.91	Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis? ( Colin, PJ; Grit, GF; Toren-Wielema, ML; Touw, DJ, 2023)
"sepsis is defined as a systemic inflammatory host response syndrome (SIRS) to infection, commonly bacterial."	1.72	Aetiology, antimicrobial susceptibility and outcome of children with sepsis, admitted at Muhimbili National Hospital, Dar es Salaam. ( Assenga, EN; Godfrey, E; Majaliwa, E, 2022)
"Sepsis is a serious problem in felines with a mortality rate ranging from 29-79%."	1.72	Commensal and multidrug-resistant Neisseria spp. sepsis in feline. ( Colodel, EM; De Barros, MA; De Sousa, ATHI; Dos Santos, TÁ; Dutra, V; Jaworski, LTBN; Koiyama, MFG; Mendonça, AJ; Néspoli, PEB; Sousa, VRF, 2022)
"To evaluate augmented renal clearance (ARC) using aminoglycoside clearance (CLAMINO24h) derived from pharmacokinetic (PK) modelling."	1.56	Augmented renal clearance of aminoglycosides using population-based pharmacokinetic modelling with Bayesian estimation in the paediatric ICU. ( Avedissian, SN; Bradley, J; Kim, Y; Le, J; Rhodes, NJ; Valdez, JL, 2020)
"Post-URS sepsis was 7."	1.56	Tailoring Antibiotic Prophylaxis for Ureteroscopic Procedures Based on Local Resistance Profiles May Lead to Reduced Rates of Infections and Urosepsis. ( Amiel, GE; Badaan, S; Kastin, A; Kravtsov, A; Mullerad, M; Zisman, A, 2020)
"Septicemia is one of the most fulminant forms, but diagnosis of C."	1.51	Infective endocarditis caused by Capnocytophaga canimorsus; a case report. ( Imanaka, K; Kawamura, T; Kodana, M; Maesaki, S; Matsuoka, T; Nishida, Y; Ohgane, K; Ohno, H; Oka, H; Sakai, J; Sekine, S; Yamamoto, K, 2019)
"Mean gentamicin dose was 4."	1.43	No increased risk of acute kidney injury after a single dose of gentamicin in patients with sepsis. ( Cobussen, M; de Kort, JM; Dennert, RM; Lowe, SH; Stassen, PM, 2016)
"Clinical sepsis is found commonly (53."	1.43	A Survey on Current Practice of Management of Early Onset Neonatal Sepsis. ( Afroze, S; Dey, AC; Dey, SK; Hossain, MI; Mannan, MA; Shahidullah, M, 2016)
"To evaluate a simplified gentamicin extended-interval dosing regimen in a large cohort of preterm and term newborns, we conducted a retrospective cohort study over a 4-year period."	1.42	Gentamicin trough levels using a simplified extended-interval dosing regimen in preterm and term newborns. ( Barfield, CP; Guy, KJ; König, K; Lim, A; Miller, A; Saker, S, 2015)
"Ciprofloxacin alone was associated with significantly more infections than ciprofloxacin plus an additional agent (P = 0."	1.42	Comparative Effectiveness of Single versus Combination Antibiotic Prophylaxis for Infections after Transrectal Prostate Biopsy. ( Gupta, K; Lerner, L; Marino, K; Orlando, R; Parlee, A; Strymish, J, 2015)
"Neonatal sepsis is a disease affecting newborns ≤1 month of age with clinical symptoms and positive blood cultures."	1.40	Characterization of CTX-M-14 and CTX-M-15 producing Escherichia coli strains causing neonatal sepsis. ( Bosch, J; Guiral, E; López, Y; Montero, I; Sáez-López, E; Soto, SM; Vila, J, 2014)
"Chorioamnionitis (CAM) is a major risk factor for neonatal sepsis."	1.40	Role of guidelines on length of therapy in chorioamnionitis and neonatal sepsis. ( Aghai, ZH; Kiser, C; McKenna, K; Nawab, U, 2014)
"Pretreatment with indomethacin and N-(G)-nitro-L-arginine methyl ester did not prevent gentamicin-induced DA relaxation."	1.40	Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. ( Brown, N; Clark, RH; Cotton, RB; Ehinger, NJ; Goettel, JA; Paria, BC; Poole, SD; Reese, J; Rojas, MA; Shelton, EL; Slaughter, JC; Vucovich, MM; Wynn, JL, 2014)
" We reviewed each admission and looked through the case notes in detail to document information about gentamicin administration, dosage and elevated gentamicin levels in the blood."	1.39	Gentamicin use in neonates: should we have a change of practice? ( Furness, J; Krishnamoorthy, SS; Nair, A; Sanderson, J, 2013)
"Neonatal sepsis is a significant cause of morbidity and mortality among term and preterm infants."	1.39	Gentamicin resistance among Escherichia coli strains isolated in neonatal sepsis. ( Attar, M; Bradford, L; Harrison, C; Hasvold, J; Nelson, C; Stillwell, T, 2013)
"Bloodstream infections are a significant cause of neonatal morbidity and death."	1.38	Antimicrobial resistance of Escherichia coli strains causing neonatal sepsis between 1998 and 2008. ( Bosch, J; Guiral, E; Soto, SM; Vila, J, 2012)
"To evaluate an extended interval dosing (EID) regimen of gentamicin in neonates ≤28-week gestation."	1.38	Extended interval dosing of gentamicin in premature neonates ≤ 28-week gestation. ( Akierman, AR; Alshaikh, B; Dersch-Mills, D; Taylor, R; Yusuf, K, 2012)
" In the LPSIL+GE group relative to C+GE, the half-life (t(1/2)) was 79% higher (p<0."	1.38	A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2. ( Chládek, J; Krs, O; Martinkova, J; Senkerik, M; Slizova, D; Springer, D; Studena, S, 2012)
"Sepsis was higher in neonates with fever and hypothermia (p=0."	1.38	Neonatal sepsis at Muhimbili National Hospital, Dar es Salaam, Tanzania; aetiology, antimicrobial sensitivity pattern and clinical outcome. ( Fredrick, F; Massawe, A; Matee, MI; Mhada, TV, 2012)
"Vancomycin, by contrast, was associated with ototoxicity."	1.37	Are gentamicin and/or vancomycin associated with ototoxicity in the neonate? A retrospective audit. ( Begg, EJ; Borrie, TL; Darlow, BA; Lynn, AM; Robertshawe, BJ; Vella-Brincat, JW, 2011)
"To develop and validate a 48-hour gentamicin dosing regimen for infants born at <28 weeks' gestation."	1.35	Observational trial of a 48-hour gentamicin dosing regimen derived from Monte Carlo simulations in infants born at less than 28 weeks' gestation. ( Caserta, M; Dicenzo, R; Guillet, R; Thingvoll, ES, 2008)
"Gentamicin is an aminoglycoside that is widely used in neonatology in spite of its known nephrotoxicity and ototoxicity."	1.35	[Gentamicin intoxication in a preterm infant]. ( Butenhoff, S; Haase, R; Lieser, U; Merkel, N, 2009)
"Spinal epidural abscess (SEA) is a rare infectious disease."	1.35	Cervicothoracolumbar spinal epidural abscess and cerebral salt wasting. ( Altunay, L; Arslan, D; Erdogan, S; Kose, M; Ozturk, MK; Yikilmaz, A, 2009)
"A proper dosing regimen is fundamental when antibiotics with a low therapeutic index, as aminoglycosides (AMG), are used."	1.34	Therapeutic drug monitoring of gentamicin in neonatal intensive care unit: experience in 68 newborns. ( Del Zompo, M; Fanos, V; Martinelli, V; Mussap, M; Stronati, M; Testa, M, 2007)
"An 18-year-old man was diagnosed with ventricular septal defect after birth."	1.34	[Pulmonary septic embolism with right side infectious endocarditis and ventricular septal defect: a case report]. ( Ishise, T; Miyamura, Y; Miyazaki, S; Nakauchi, Y; Taniguchi, M, 2007)
" 24 hour concentrations of > 1 mg/L were considered high, and an indication to extend the dosing interval."	1.33	"Random" gentamicin concentrations do not predict trough levels in neonates receiving once daily fixed dose regimens. ( Boyle, EM; Brookes, I; Nye, K; Riordan, FA; Watkinson, M, 2006)
"Population pharmacokinetic parameter estimates were calculated from 725 routine plasma gentamicin concentrations obtained in 177 neonates of 24 to 42 weeks' gestational age in their first week of life."	1.31	Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates. ( de Boer, A; de Wolf, MC; Degraeuwe, PL; Nieman, FH; Stolk, LM, 2002)
"The mean age of patients with a surgical site infection ranged from 12 to 15."	1.31	A retrospective review of three antibiotic prophylaxis regimens for pediatric cardiac surgical patients. ( Bove, EL; Chenoweth, CE; Kulik, TJ; Maher, KO; Mosca, RS; VanDerElzen, K, 2002)
" There was a large degree of inter-patient variability in serum concentrations and serum half-life (t1/2), volume of distribution (VD), area-under-the-curve (AUC), relative serum clearance (Clp) such that these parameters could not be correlated to age or weight."	1.31	Pharmacokinetics of once-a-day netilmicin (4.5 mg/kg) in neonates. ( Bedford, KA; Dixon, JJ; Gosden, PE; Leaf, AA; Macgowan, AP; Speidel, BD, 2001)
"The objective of this study was to confirm the variation of the pharmacokinetic parameters of gentamicin in neonates and to establish guidelines for a dosage regimen."	1.30	[Monitoring of gentamycin serum concentration in neonates. Usefulness in adjustment of dosage]. ( García-Delgado, R; Marco-Macián, A; Sánchez-Romero, A; Tébar-Gil, R, 1997)
"Ciprofloxacin has been found to be effective in the treatment of multidrug-resistant Gram-negative infections in pediatric patients, including premature infants."	1.30	Successful treatment of late-onset infection due to resistant Klebsiella pneumoniae in an extremely low birth weight infant using ciprofloxacin. ( Khaneja, M; Kumar, A; Naprawa, J; Piecuch, S, 1999)
"All the babies had septic arthritis and ten cases had osteomyelitis in addition: multiple joint involvement occurred in 50% of cases."	1.29	Klebsiella septicaemia, osteomyelitis and septic arthritis in neonates in Ibadan, Nigeria. ( Adeyemo, AA; Akindele, JA; Omokhodion, SI, 1993)
"During 1967 to 1985, three cases of listeriosis were reported in Algeria; at that time Listeria monocytogenes caused several thousand cases of meningitis and sepsis in the world."	1.28	[Prospective study of Listeria in humans and animals]. ( Belouni, R; Rahal, K, 1992)
"coli-positive blood cultures died of septicemia."	1.28	Antimicrobial gentamicin activity in the presence of exogenous protease inhibitor (Bowman-Birk inhibitor) in gentamicin-induced nephrotoxicity in rats. ( Bar-Khayim, Y; Birk, Y; Khalef, S; Smetana, S, 1992)
"Ampicillin resistance was mainly found in very low and low birthweight infants with late-onset infections, in which aerobic Gram-negative rods were common pathogens."	1.28	Ampicillin-aminoglycoside combinations as initial treatment for neonatal septicaemia or meningitis. A retrospective evaluation of 12 years' experience. ( Larsson, P; Tessin, I; Thiringer, K; Trollfors, B, 1991)
" coli and Klebsiella oxytoca were tested for their synergistic and cumulated killing effect (CKE) with the new penems FCE 22101 or FCE 25199 in combination with gentamicin."	1.28	Synergy and cumulated killing effect of the penems FCE 22101 and FCE 25199 in combination with gentamicin against bacteria isolated from septicaemia. ( Bergholm, AM; Dornbusch, K, 1991)
"The impact of the dosage schedule on the therapeutic efficacy of antibiotics was investigated in experimental Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats."	1.28	Impact of the dosage schedule on the efficacy of ceftazidime, gentamicin and ciprofloxacin in Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats. ( Bakker-Woudenberg, IA; Michel, BM; Roosendaal, R; van den Berghe-van Raffe, M; Vink-van den Berg, JC, 1989)
"The in vitro and in vivo activities of mezlocillin and ampicillin, alone and in combination with gentamicin, against Streptococcus faecalis were compared."	1.27	Comparative efficacies of mezlocillin and ampicillin alone or in combination with gentamicin in the treatment of Streptococcus faecalis endocarditis in rabbits. ( Fass, RJ; Wright, CA, 1984)
" to 36 newborn infants using a dosage schedule and the results were compared with those obtained in an earlier study including 88 infants who received individually calculated dosages."	1.27	Continuous intravenous infusion of ampicillin and gentamicin during parenteral nutrition to 36 newborn infants using a dosage schedule. ( Andersen, GE; Colding, H; Møller, S, 1984)
"Gentamicin resistance was chromosomally encoded."	1.27	Methicillin-resistant Staphylococcus aureus in Dublin 1971-84. ( Cafferkey, MT; Coleman, D; Hone, R; Keane, CT; McGrath, B; Pomeroy, H; Ruddy, R, 1985)
"Imipenem was evaluated for its in vitro and in vivo activities alone and in combination with gentamicin against a clinical isolate of Listeria monocytogenes, and the results were compared with the activities of ampicillin with and without gentamicin."	1.27	In vitro and in vivo studies of imipenem-cilastatin alone and in combination with gentamicin against Listeria monocytogenes. ( Kim, KS, 1986)
" Because of this long-term use of gentamicin, a retrospective analysis of gentamicin resistance among gram-negative bacillary blood isolates was performed."	1.27	Gentamicin resistance among gram-negative bacillary blood isolates in a hospital with long-term use of gentamicin. ( Mylotte, JM, 1987)
" Irrespective of dosage interval there was a marked fall in bacteraemia with each of the first two doses."	1.27	Influence of dosage interval on the therapeutic response to gentamicin in mice infected with Klebsiella pneumoniae. ( Bathirunathan, N; Mawer, GE; Queiroz, ML, 1987)
" coli and should be used in combination with ampicillin to achieve an outcome comparable to that of gentamicin in this model of E."	1.27	Comparison of gentamicin and kanamycin alone and in combination with ampicillin in experimental Escherichia coli bacteremia and meningitis. ( Kim, KS, 1985)
"The infections were septicemia in 9 patients, suspected septicemia in 48, respiratory tract infection in 7, and perianal abscess in 2."	1.27	[Therapeutic effects of micronomicin against severe infections in patients with hematopoietic disorders. Hanshin Infection Study Group]. ( Hasegawa, H; Horiuchi, A; Kanamaru, A; Kitani, T; Masaoka, T; Nagai, K; Okamoto, Y; Shibata, H; Taniguchi, N; Yasunaga, K, 1985)
"Netilmicin was the only antibiotic active in vitro against P aeruginosa that was administered to these patients."	1.27	Netilmicin in the treatment of Pseudomonas bacteremia. ( Linzmayer, MI; Lorber, RR, 1985)
"Cefoxitin (CFX) was administrated to a total of 12 hospitalized patients with digestive diseases, in combination with aminoglycosides."	1.27	[Clinical effects of cefoxitin on infections in digestive diseases]. ( Irie, T; Mae, S; Sakai, H, 1985)
"Netilmicin was administered intramuscularly in a dose of 2 mg/kg body weight every 8 hours."	1.26	Netilmicin therapy of patients with septicaemia and other severe infections. ( Brandenhoff, P; Bretlau, P; Gammelgaard, PA; Jensen, SH; Rasmussen, F; Stafanger, G; Thomsen, VF, 1980)
"Netilmicin appears to be an effective and safe drug in the treatment of a variety of bacterial infections."	1.26	High dose netilmicin therapy of severe or chronic infections. ( Digranes, A; Hellum, KB; Madsen, ST; Solberg, CO; Stokstad, S, 1980)
"Ampicillin was not associated with pure filament formation at concentrations below the minimum inhibitory concentration, and gentamicin produced no filaments at any concentration."	1.26	Aberrant forms of Escherichia coli in blood cultures: in vitro reproduction of an in vivo observation. ( Hruska, JF; Magnussen, CR, 1980)
"Maternal septicemia with Listeria monocytogenes is becoming a more prevalent problem for those dealing with obstetric patients."	1.26	Antepartum treatment of Listeria monocytogenes septicemia. ( Katz, VL; Weinstein, L, 1982)
"A third patient with chronic renal failure acquired A hydrophila pneumonia at home and quickly died from the infection."	1.26	Pneumonia and bacteremia due to Aeromonas hydrophila. ( Cook, FV; Reines, HD, 1981)
"100 suffered from mediastinitis, and 4 p."	1.26	[Prevention of post-operative infection in heart surgery with extracorporeal circulation (apropos of 295 cases)]. ( Coulombe, G; Hubscher, C; Laborde, F; Oksenhendler, G; Soyer, R; Winckler, C, 1979)
" A retrospective study was conducted to evaluate the impact, in terms of patient outcomes, of individualizing gentamicin dosage regimens in severely burned patients."	1.26	Individualizing gentamicin dosage regimens in burn patients with gram-negative septicemia: a cost--benefit analysis. ( Bootman, JL; Rowland, C; Wertheimer, AI; Zaske, D, 1979)
"Gentamicin sulfate has been shown to enhance the effects of penicillinase-resistant penicillins against clinical isolates of Staphylococcus aureus in vitro, but the relevance of this observation to bacteremic patients is unclear."	1.26	Penicillinase-resistant penicillin/gentamicin synergism. Effect in patients with Staphylococcus aureus bacteremia. ( Licht, JH, 1979)
"Endophthalmitis is but one of the apparently increasing number of unsuual complications that may be observed as a result of H influenzae type b bacteremia."	1.26	Endophthalmitis associated with Haemophilus influenzae type b bacteremia and meningitis. ( Baker, CJ; Sastry, RV, 1979)
" A dosage of 75 mg/kg fosfomycin enables serum levels of about 32 mug/ml during 4-5 h, being this level higher to the MIC of all isolated strains of S."	1.26	Antibiotherapy of Serratia marcescens septicemia in children. ( Baquero, F; Cañedo, T; Hortelano, JG; Jara, P; Navarro, M; Rodríguez, A; Scarpellini, A, 1977)
"Amikacin sulfate was used in 24 treatment courses for 25 serious infections caused by aerobic or facultative anaerobic Gram-negative organisms resistant to numerous drugs."	1.26	Amikacin therapy. Use against infections caused by gentamicin- and tobramycin-resistant organisms. ( Axline, SG; Pesanti, EL; Rhame, FS; Yu, VL, 1977)
"Netilmicin appears to be an effective, safe agent for the therapy of serious infections."	1.26	Clinical evaluation of netilmicin therapy in serious infections. ( Fu, KP; Jahre, JA; Neu, HC, 1979)
"Gentamicin has been relied upon in some antibiotic combinations against Staphylococcus aureus, should it be present."	1.26	Gentamicin failure in staphylococcal bacteremia. ( Reynolds, RJ; West, BC, 1979)
"Yersinia pseudotuberculosis septicemia and postdiarrheal hemolytic-uremia syndrome (HUS) developed in a 15-month-old boy after he ingested unpasteurized goat's milk."	1.26	Yersinia pseudotuberculosis septicemia. ( Hoder, L; Prober, CG; Tune, B, 1979)
"Amikacin sulfate was administered to 18 patients for the treatment of 19 severe infections."	1.26	Amikacin therapy for serious gram-negative infection. ( Berger, SA; Pollock, AA; Rahal, JJ; Richmond, AS; Simberkoff, MS, 1977)
" coli in patients treated with gentamicin in adequate dosage and was associated with leukopenia or undrained purulent collections."	1.26	Simultaneous antibiotic levels in "breakthrough" gram-negative rod bacteremia. ( Anderson, ET; Hewitt, WL; Young, LS, 1976)
"Tobramycin was at least twice as active as gentamicin against P."	1.26	Laboratory findings of tobramycin and their relation to clinical response. ( McAllister, TA; Tait, SC, 1976)
"Treatment with amikacin was evaluated in 15 patients with gram-negative bacteremia."	1.26	Amikacin therapy of gram-negative bacteremia. ( Gorbach, SL; Tally, FP, 1977)
"Gentamicin (GM) was intramuscularly administered to 24 patients with various infections (including 1 for prophylaxis of a postoperative infection) in the dose of 40 mg X 2/day for 4-26 days."	1.26	[Clinical use of gentamicin in the field of surgery (author's transl)]. ( Ishii, T; Kishi, D; Nakai, S; Sugihara, H; Yokoyama, T, 1976)
"Meningitis was documented in only the four who received kidney transplants."	1.25	Listeroisis in immunosuppressed patients. A cluster of eight cases. ( Carrera, GF; Gantz, NM; Medeiros, AA; Myerowitz, RL; O'Brien, TF; Wilson, RE, 1975)
" In a second series of 27 orthotopic liver transplantations in tissue-typed littermate dogs and littermate pigs the standard surgical technique and aftercare were changed with regard to four factors: an end-to-end common bile duct anastomosis was made instead of a gallbladder to duodenum anastomosis; the continuous postoperative bacteriostatic antibiotic therapy was changed to a single 2-day course of bactericidal antibiotics; preoperative selective bowel decontamination combined with postoperative protective isolation was introduced; the dosage of azathioprine used for immunosuppression was reduced."	1.25	Orthotopic liver transplantation: an experimental study on the prevention of infections with Gram-negative organisms. ( Hendriks, WD; Jerusalem, C; Krom, RA; Popescu, DT; Schalm, SW; Terpstra, JL; Van Der Waay, D, 1975)
"Gentamicin was administered at 7."	1.25	Kanamycin and gentamicin treatment of neonatal sepsis and meningitis. ( Anderson, DC; Chang, MJ; Escobedo, M; Feigin, RD; Hillman, L, 1975)
"Peak concentrations and half-life of gentamicin in serum were measured after 140 intravenous and 13 intramuscular doses in 52 children and 17 adults with normal levels of creatinine in serum."	1.25	Pharmacokinetics of gentamicin in children and adults. ( Echeverria, P; Paisley, JW; Siber, GR; Smith, AL; Smith, DH, 1975)
"Gentamicin was the single most useful antibiotic, and the infection was controlled largely with gentamicin and one other antibiotic, most often carbenicillin."	1.25	Septicaemia in the neutropenic patient. ( Atkinson, K; Kay, HE; McElwain, TJ, 1974)

Timeframe	Studies, this research(%)	All Research%
pre-1990	459 (67.20)	18.7374
1990's	59 (8.64)	18.2507
2000's	50 (7.32)	29.6817
2010's	81 (11.86)	24.3611
2020's	34 (4.98)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis: an Open-label Safety and Pharmacokinetics Study (neoFosfo)[NCT03453177]	Phase 2	120 participants (Actual)	Interventional	2018-03-15	Completed
Differentiation of Acute Kidney Injury in Sepsis and Due to Nephrotoxic Antibiotic Treatment With Vancomycin and Gentamicin Based on Measurements of Specific miRNAs[NCT04991376]		53 participants (Actual)	Observational	2019-05-02	Completed
Aminoglycoside Plasma Level Measurement in Neonates With Infection[NCT01624324]		25 participants (Anticipated)	Observational	2010-11-30	Recruiting
Auditive and Renal Long Term Outcomes - Risk After Aminoglycoside Therapy in Neonates (AURORA-study)[NCT03253614]		226 participants (Actual)	Observational	2017-09-15	Completed
Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia: a National Multicenter Observational Study[NCT03597841]		278 participants (Actual)	Observational	2018-06-25	Completed
Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes. A Randomized Prospective, Open Trial[NCT02819570]	Phase 4	400 participants (Anticipated)	Interventional	2015-11-30	Recruiting
Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis[NCT02898961]	Phase 4	63 participants (Actual)	Interventional	2014-10-31	Completed
Population Pharmacokinetics Modeling : a Priori Optimization of Amikacin First Dose in Critically Ill Patients Using a Nomogram[NCT03683511]		138 participants (Actual)	Observational	2014-04-21	Completed
Prevention of Maternal and Neonatal Death/Infections With a Single Oral Dose of Azithromycin in Women in Labor (in Low- and Middle-income Countries): a Randomized Controlled Trial[NCT03871491]	Phase 3	34,000 participants (Anticipated)	Interventional	2020-09-01	Active, not recruiting
Simplified Antibiotic Regimens for the Management of Sepsis in Young Infants in First-level Facilities: Randomized Controlled Trial[NCT01027429]	Phase 3	2,543 participants (Actual)	Interventional	2009-12-31	Completed
A Randomized Clinical Trial Between Clindamycin Once and Thrice a Day in Septic Abortion.[NCT02309346]	Phase 4	190 participants (Anticipated)	Interventional	2014-12-31	Recruiting
A Phase 1, Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of a Single 3 Gram Dose of Cefazolin in Adult Subjects Weighing >= 120 kg Scheduled for Surgery[NCT05205486]	Phase 1	12 participants (Actual)	Interventional	2022-04-05	Completed
Population Pharmacokinetics of Amikacin in Suspected Cases of Neonatal Sepsis: Multicenter Study[NCT04867135]		138 participants (Actual)	Observational	2019-12-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Efficacy of empiric antibiotic treatment of late-onset neonatal sepsis caused by Enterobacteriaceae: A systematic review. Letters in applied microbiology, 2022, Volume: 75, Issue:3 Topics: Ampicillin; Anti-Bacterial Agents; Cephalosporins; Enterobacteriaceae; Escherichia coli; Gentamicins	2022
Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents-Pathophysiology and Biomarkers-A Review. International journal of molecular sciences, 2020, Sep-26, Volume: 21, Issue:19 Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Biomarkers; Gentamicins; Humans; Kidney; MicroR	2020
Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children. Paediatrics and international child health, 2018, Volume: 38, Issue:sup1 Topics: Administration, Oral; Adolescent; Amoxicillin; Anti-Bacterial Agents; Child; Child, Preschool; Genta	2018
Antibiotic regimens for management of intra-amniotic infection. The Cochrane database of systematic reviews, 2014, Dec-19, Issue:12 Topics: Amnion; Ampicillin; Anti-Bacterial Agents; Cefotetan; Chorioamnionitis; Clindamycin; Delivery, Obste	2014
Empiric treatment of neonatal sepsis in developing countries. The Pediatric infectious disease journal, 2015, Volume: 34, Issue:6 Topics: Anti-Bacterial Agents; beta-Lactams; Developing Countries; Gentamicins; Humans; Infant, Newborn; Inf	2015
Risk of gentamicin toxicity in neonates treated for possible severe bacterial infection in low- and middle-income countries: Systematic Review. Tropical medicine & international health : TM & IH, 2015, Volume: 20, Issue:12 Topics: Anti-Bacterial Agents; Bacterial Infections; Developing Countries; Ear Diseases; Gentamicins; Humans	2015
One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. The Cochrane database of systematic reviews, 2016, 12-06, Volume: 12 Topics: Anti-Bacterial Agents; Drug Administration Schedule; Gentamicins; Hearing; Humans; Infant, Newborn;	2016
Extended-interval dosing of gentamicin for treatment of neonatal sepsis in developed and developing countries. Journal of health, population, and nutrition, 2008, Volume: 26, Issue:2 Topics: Anti-Bacterial Agents; Body Weight; Developed Countries; Developing Countries; Dose-Response Relatio	2008
Antioxidants. Do they have a place in the prevention or therapy of acute kidney injury? Nephron. Experimental nephrology, 2008, Volume: 109, Issue:4 Topics: Acute Kidney Injury; Animals; Antioxidants; Clinical Trials as Topic; Coronary Artery Bypass; Gentam	2008
Clostridium perfringens septicaemia with massive intravascular haemolysis: a case report and review of the literature. The Netherlands journal of medicine, 2010, Volume: 68, Issue:9 Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Cholangitis; Clostridium Infections; Clostridium perfringe	2010
One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. The Cochrane database of systematic reviews, 2011, Nov-09, Issue:11 Topics: Anti-Bacterial Agents; Drug Administration Schedule; Gentamicins; Hearing; Humans; Infant, Newborn;	2011
[An effect of continuous and intermittent renal replacement therapy on antibiotic treatment in critically ill patients with sepsis - a practice-based perspective of vancomycin and gentamycin therapies]. Vnitrni lekarstvi, 2012, Volume: 58, Issue:6 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Critical Illness; Gentamicins; Humans; Renal Dialysis; S	2012
One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. The Cochrane database of systematic reviews, 2006, Jan-25, Issue:1 Topics: Anti-Bacterial Agents; Drug Administration Schedule; Ear Diseases; Gentamicins; Humans; Infant, Newb	2006
Neonatal sepsis-- a global problem: an overview. Mymensingh medical journal : MMJ, 2006, Volume: 15, Issue:1 Topics: Ampicillin; Developing Countries; Female; Gentamicins; Global Health; Hand Disinfection; Humans; Inf	2006
Clinical inquiries. What treatment approach to intrapartum maternal fever has the best fetal outcomes? The Journal of family practice, 2007, Volume: 56, Issue:5 Topics: Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Chorioamnionitis; Clindamycin; Female; Gentamici	2007
Clinical review of the aminoglycosides. Scandinavian journal of infectious diseases. Supplementum, 1980, Volume: Suppl 23 Topics: Abscess; Aminoglycosides; Anti-Bacterial Agents; Gentamicins; Humans; Meningitis; Sepsis; Tobramycin	1980
Flavimonas oryzihabitans sepsis in children. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 22, Issue:4 Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Child; Child Nutrition Disorder	1996
Pseudomonas diseases. Advances in internal medicine, 1975, Volume: 20 Topics: Animals; Antibodies, Bacterial; Antigens, Bacterial; Carbenicillin; Cross Infection; gamma-Globulins	1975
Prevention of bacterial endocarditis. Circulation, 1977, Volume: 56, Issue:1 Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cardiac Surgical Procedures; Catheters, Indwelling; Child;	1977
A review. Lessons from an animal model of intra-abdominal sepsis. Archives of surgery (Chicago, Ill. : 1960), 1978, Volume: 113, Issue:7 Topics: Abdomen; Abscess; Animals; Anti-Bacterial Agents; Bacteroides fragilis; Barium Sulfate; Cecum; Clind	1978
Antibiotics in surgery. Advances in surgery, 1975, Volume: 9 Topics: Anti-Bacterial Agents; Bacterial Infections; Biliary Tract Diseases; Burns; Catheterization; Cephalo	1975
Group G streptococcal neonatal septicaemia: two case reports and a brief review of literature. Scandinavian journal of infectious diseases, 1988, Volume: 20, Issue:4 Topics: Adult; Female; Gentamicins; Humans; Infant, Newborn; Male; Penicillin G; Pregnancy; Pregnancy Compli	1988
Aminoglycoside antibiotics in infectious diseases. An overview. The American journal of medicine, 1986, Jun-30, Volume: 80, Issue:6B Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Drug Resistance, Microbial;	1986
[Burn therapy in foreign countries]. Zhonghua yi xue za zhi, 1973, Volume: 4 Topics: Animals; Antitoxins; Burns; Dogs; gamma-Globulins; Gentamicins; Humans; Pseudomonas aeruginosa; Pseu	1973
Bacteremic shock due to gram-negative bacilli. Some concepts of pathogenesis and management based on recent developments. Geriatrics, 1969, Volume: 24, Issue:4 Topics: Animals; Bacteroides Infections; Chloramphenicol; Enterobacter; Escherichia coli Infections; Gentami	1969
The chemotherapy of enterobacterial infections. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1968, Volume: 12 Topics: Ampicillin; Anti-Bacterial Agents; Cephaloridine; Cephalothin; Chloramphenicol; Enterobacteriaceae;	1968
The management of bacteremic shock. International anesthesiology clinics, 1969,Winter, Volume: 7, Issue:4 Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Burns; Catheterization; Cephaloridine; Cephalot	1969
Management of infections in patients with leukemia and lymphoma: current concepts and experimental approaches. Seminars in hematology, 1972, Volume: 9, Issue:2 Topics: Amphotericin B; Ampicillin; Antifungal Agents; Bacterial Infections; Blood Transfusion; Bone Marrow	1972
Sepsis neonatorum. Pediatric clinics of North America, 1974, Volume: 21, Issue:3 Topics: Ampicillin; Bacteria; Bacterial Infections; Enterobacteriaceae; Gentamicins; Humans; Infant, Newborn	1974
Topical antibacterial therapy of the burn wound. Clinics in plastic surgery, 1974, Volume: 1, Issue:4 Topics: Administration, Topical; Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Biopsy; Blo	1974
Antimicrobiol therapy: therapeutic recommendations and a review of newer drugs. Part I. Therapy of infectious conditions. The Journal of pediatrics, 1974, Volume: 85, Issue:3 Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Arthritis, Infectious; Bacteroides Infections; Brain	1974
Cardiocirculatory adaptation to chronic hypoxia. 3. Comparative study of cardiac output, pulmonary and systemic circulation between sea level and high altitude residents. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1972, Volume: 17, Issue:5 Topics: Bacterial Infections; Carbenicillin; Drug Stability; Drug Synergism; Escherichia coli; Gentamicins;	1972
[Actual problems in clinical chemotherapy]. Der Internist, 1967, Volume: 8, Issue:6 Topics: Anti-Bacterial Agents; Antitubercular Agents; Cephalosporins; Endocarditis, Bacterial; Enteritis; Ge	1967
Gentamicin: antibacterial activity, clinical pharmacology and clinical applications. Medical times, 1969, Volume: 97, Issue:12 Topics: Animals; Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry; Communicable Diseases; Drug	1969
Gentamicin. The Medical clinics of North America, 1970, Volume: 54, Issue:5 Topics: Absorption; Drug Synergism; Enterobacteriaceae; Enterobacteriaceae Infections; Gentamicins; Humans;	1970
[Basic principles of effective antibiotic therapy]. Medizinische Klinik, 1971, Nov-05, Volume: 66, Issue:45 Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Biliary Tract Diseases; Carbenicillin; Ceph	1971

Article	Year
Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload. Archives of disease in childhood, 2022, Volume: 107, Issue:9 Topics: Anti-Bacterial Agents; Child; Fosfomycin; Gentamicins; Humans; Infant; Infant, Newborn; Neonatal Sep	2022
Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis. The Journal of antimicrobial chemotherapy, 2022, 02-02, Volume: 77, Issue:2 Topics: Ampicillin; Anti-Bacterial Agents; Escherichia coli; Gentamicins; Humans; Infant, Newborn; Neonatal	2022
Topical gentamicin for the prevention of tunneled hemodialysis catheter-related infections: a randomized double-blind study. Journal of nephrology, 2023, Volume: 36, Issue:7 Topics: Aged; Catheter-Related Infections; Catheterization, Central Venous; Catheters, Indwelling; Double-Bl	2023
Chemoprophylaxis during transrectal prostate needle biopsy: critical analysis through randomized clinical trial. World journal of urology, 2018, Volume: 36, Issue:11 Topics: Adenocarcinoma; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Biopsy, Large-Core Needle; Bloo	2018
The use of initial dosing of gentamicin in the management of pyelonephritis/urosepsis: A retrospective study. PloS one, 2019, Volume: 14, Issue:1 Topics: Age Factors; Aged; Female; Gentamicins; Humans; Length of Stay; Male; Middle Aged; Pyelonephritis; S	2019
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Chromatography, Liquid; Ear Diseases; Female; Gentamicins; Hearing;	2013
Comparison of two empiric antibiotic regimen in late onset neonatal sepsis--a randomized controlled trial. Journal of tropical pediatrics, 2014, Volume: 60, Issue:1 Topics: Amikacin; Anti-Bacterial Agents; Bacterial Infections; Cefotaxime; Cloxacillin; Drug Therapy, Combin	2014
Simplified antibiotic regimens for treatment of clinical severe infection in the outpatient setting when referral is not possible for young infants in Pakistan (Simplified Antibiotic Therapy Trial [SATT]): a randomised, open-label, equivalence trial. The Lancet. Global health, 2017, Volume: 5, Issue:2 Topics: Ambulatory Care; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Female; Gentamicins; Huma	2017
Simplified antibiotic regimens for treatment of clinical severe infection in the outpatient setting when referral is not possible for young infants in Pakistan (Simplified Antibiotic Therapy Trial [SATT]): a randomised, open-label, equivalence trial. The Lancet. Global health, 2017, Volume: 5, Issue:2 Topics: Ambulatory Care; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Female; Gentamicins; Huma	2017
Simplified antibiotic regimens for treatment of clinical severe infection in the outpatient setting when referral is not possible for young infants in Pakistan (Simplified Antibiotic Therapy Trial [SATT]): a randomised, open-label, equivalence trial. The Lancet. Global health, 2017, Volume: 5, Issue:2 Topics: Ambulatory Care; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Female; Gentamicins; Huma	2017
Simplified antibiotic regimens for treatment of clinical severe infection in the outpatient setting when referral is not possible for young infants in Pakistan (Simplified Antibiotic Therapy Trial [SATT]): a randomised, open-label, equivalence trial. The Lancet. Global health, 2017, Volume: 5, Issue:2 Topics: Ambulatory Care; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Female; Gentamicins; Huma	2017
Tunneled catheter-antibiotic lock therapy for prevention of dialysis catheter-related infections: a single center experience. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2008, Volume: 19, Issue:4 Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Catheterization, Central Venous; Child; Creatini	2008
Simplified dosing of gentamicin for treatment of sepsis in Bangladeshi neonates. Journal of health, population, and nutrition, 2009, Volume: 27, Issue:5 Topics: Anti-Bacterial Agents; Bangladesh; Body Weight; Clinical Protocols; Developing Countries; Drug Admin	2009
Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis. Acta paediatrica (Oslo, Norway : 1992), 2010, Volume: 99, Issue:5 Topics: Age of Onset; Ampicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Estonia; Female; Gentami	2010
Community-based treatment of serious bacterial infections in newborns and young infants: a randomized controlled trial assessing three antibiotic regimens. The Pediatric infectious disease journal, 2012, Volume: 31, Issue:7 Topics: Anti-Bacterial Agents; Bacterial Infections; Ceftriaxone; Community-Acquired Infections; Female; Gen	2012
A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates. Pharmacotherapy, 2003, Volume: 23, Issue:5 Topics: Algorithms; Anti-Bacterial Agents; Bayes Theorem; Birth Weight; Drug Administration Schedule; Gentam	2003
Once daily gentamicin dosing in full term neonates. Saudi medical journal, 2003, Volume: 24, Issue:9 Topics: Anti-Bacterial Agents; Birth Weight; Dose-Response Relationship, Drug; Gentamicins; Gestational Age;	2003
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants. Archives of disease in childhood, 2004, Volume: 89, Issue:7 Topics: Anti-Bacterial Agents; Drug Administration Schedule; Gentamicins; Humans; Infant, Newborn; Kenya; Ru	2004
Once versus twice daily dose of gentamicin therapy in Thai neonates. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2004, Volume: 87, Issue:4 Topics: Anti-Bacterial Agents; Drug Administration Schedule; Gentamicins; Humans; Infant, Newborn; Sepsis	2004
Locking of tunneled hemodialysis catheters with gentamicin and heparin. Kidney international, 2004, Volume: 66, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anemia; Anti-Bacterial Agents; Anticoagulants; Catheterization; Cros	2004
Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3 Topics: Animals; Arteries; Blood Pressure; Female; Gentamicins; Hemodynamics; Lung; Nitrates; Nitric Oxide;	2005
Metronidazole need not be combined with an aminoglycoside when used for prophylaxis in elective colorectal surgery. The Journal of hospital infection, 1983, Volume: 4, Issue:1 Topics: Abscess; Aged; Colon; Drug Therapy, Combination; Female; Gentamicins; Humans; Male; Metronidazole; M	1983
Comparative studies of ticarcillin and mezlocillin plus sisomicin in Gram-negative bacillary bacteraemia and bronchopneumonia. The Journal of antimicrobial chemotherapy, 1982, Volume: 10, Issue:4 Topics: Anti-Bacterial Agents; Blood Bactericidal Activity; Bronchopneumonia; Drug Therapy, Combination; Fem	1982
[Results of treatment of bacterial infections in newborn infants with netilmicin]. Pediatria polska, 1984, Volume: 59, Issue:6 Topics: Bacterial Infections; Clinical Trials as Topic; Diarrhea, Infantile; Female; Follow-Up Studies; Gent	1984
Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. The Journal of infectious diseases, 1984, Volume: 149, Issue:1 Topics: Amikacin; Body Temperature; Female; Gentamicins; Hearing Loss; Humans; Kanamycin; Male; Probability;	1984
Prospective comparative study of efficacy and toxicity of netilmicin and amikacin. Antimicrobial agents and chemotherapy, 1980, Volume: 17, Issue:2 Topics: Adult; Aged; Amikacin; Bacterial Infections; Clinical Trials as Topic; Drug Resistance, Microbial; F	1980
Tobramycin versus gentamicin, in combination with cephalotin and carbenecillin, in patients undergoing bone marrow transplantation. Tumori, 1981, Dec-31, Volume: 67, Issue:6 Topics: Adolescent; Adult; Agranulocytosis; Anti-Bacterial Agents; Bone Marrow Transplantation; Carbenicilli	1981
Modification of endoscopic retrograde cholangiopancreatography (ERCP) septic complications by the addition of an antibiotic to the contrast media. Randomized controlled investigation. The American journal of gastroenterology, 1980, Volume: 74, Issue:6 Topics: Adolescent; Adult; Aged; Biliary Tract Diseases; Cholangiopancreatography, Endoscopic Retrograde; Co	1980
Aminoglycosides in the treatment of bacteraemic infections in the immuno-comprised host. The Journal of antimicrobial chemotherapy, 1981, Volume: 8 Suppl A Topics: Agranulocytosis; Amikacin; Aminoglycosides; Anti-Bacterial Agents; Drug Therapy, Combination; Gentam	1981
The role of systemic antibiotics in operations upon the colon. Surgery, gynecology & obstetrics, 1981, Volume: 153, Issue:4 Topics: Anti-Bacterial Agents; Cefamandole; Clindamycin; Colon; Drug Therapy, Combination; Erythromycin; Gen	1981
Randomised study comparing imipenem/cilastatin to ceftriaxone plus gentamicin in cancer chemotherapy-induced neutropenic fever. Annals of the Academy of Medicine, Singapore, 1994, Volume: 23, Issue:6 Topics: Antineoplastic Agents; Ceftriaxone; Cilastatin; Cilastatin, Imipenem Drug Combination; Costs and Cos	1994
Identification of sepsis in neonates following maternal antibiotic therapy. Clinical pediatrics, 1995, Volume: 34, Issue:3 Topics: Ampicillin; Female; Gentamicins; Humans; Infant, Newborn; Labor, Obstetric; Latex Fixation Tests; Le	1995
A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients. Hepatology (Baltimore, Md.), 1997, Volume: 25, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ceftazidime; Cephalosporins; Drug Therapy, Combination;	1997
Once- versus twice-daily gentamicin dosing in neonates >/=34 Weeks' gestation: cost-effectiveness analyses. Pediatrics, 1999, Volume: 103, Issue:3 Topics: Cost-Benefit Analysis; Costs and Cost Analysis; Gentamicins; Humans; Infant, Newborn; Prospective St	1999
Randomized controlled trial of once vs. twice daily gentamicin therapy in newborn. Indian pediatrics, 1999, Volume: 36, Issue:2 Topics: Gentamicins; Humans; Infant, Newborn; Sepsis	1999
Comparison of two gentamicin dosing schedules in very low birth weight infants. The Pediatric infectious disease journal, 2002, Volume: 21, Issue:3 Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Administration Schedule; Female; Gentamicins; Huma	2002
A comparative study of ticarcillin plus tobramycin versus carbenicillin plus gentamicin for the treatment of serious infections due to gram-negative bacilli. The American journal of medicine, 1978, Volume: 64, Issue:6 Topics: Anti-Bacterial Agents; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combination; Gentamicins; Gram-	1978
Controlled comparison of amikacin and gentamicin. The New England journal of medicine, 1977, Feb-17, Volume: 296, Issue:7 Topics: Adult; Aged; Amikacin; Bacteria; Bacterial Infections; Clinical Trials as Topic; Drug Evaluation; Dr	1977
Netilmicin: clinical efficacy, tolerance, and toxicity. Antimicrobial agents and chemotherapy, 1978, Volume: 13, Issue:2 Topics: Adolescent; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Female; Gentamicins; Humans	1978
Septic complications in colo-rectal surgery after 24 hours versus 60 hours of preoperative antibiotic bowel preparation. I. Prospective, randomized, double-blind clinical study. Acta chirurgica Scandinavica, 1978, Volume: 144, Issue:7-8 Topics: Adult; Aged; Anti-Bacterial Agents; Clinical Trials as Topic; Colectomy; Colon; Colostomy; Double-Bl	1978
Septic complications in colo-rectal surgery after 24 hours versus 60 hours of preoperative antibiotic bowel preparation. II. Significance of bacterial concentrations in the bowel for contamination of the operation field and subsequent wound infection. Acta chirurgica Scandinavica, 1978, Volume: 144, Issue:7-8 Topics: Adult; Aged; Anti-Bacterial Agents; Ascitic Fluid; Bacteria; Clinical Trials as Topic; Colectomy; Co	1978
Randomized trial of empiric antibiotic therapy with ticarcillin in combination with gentamicin, amikacin or netilmicin in febrile patients with granulocytopenia and cancer. The American journal of medicine, 1979, Volume: 66, Issue:4 Topics: Adolescent; Adult; Aged; Agranulocytosis; Amikacin; Bacterial Infections; Clinical Trials as Topic;	1979
[Sepsis caused by Serratia marcescens. Report of 19 cases]. Revista clinica espanola, 1979, Oct-31, Volume: 155, Issue:2 Topics: Adult; Aged; Clinical Trials as Topic; Female; Gentamicins; Humans; Male; Middle Aged; Sepsis; Serra	1979
Comparative efficacy and toxicity of amikacin/carbenicillin versus gentamicin/carbenicillin in leukopenic patients: a randomized prospective trail. The American journal of medicine, 1977, Volume: 62, Issue:6 Topics: Adult; Amikacin; Bacterial Infections; Carbenicillin; Drug Synergism; Gentamicins; Hearing Disorders	1977
Evaluation of three antibiotic programs in newborn infants. Canadian Medical Association journal, 1978, Mar-18, Volume: 118, Issue:6 Topics: Amikacin; Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Bilirubin; Cepha	1978
Prospective randomly controlled trial of three antibiotic combinations for empirical therapy of suspected sepsis in neutropenic cancer patients. European journal of cancer, 1975, Volume: 11suppl Topics: Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Cephalothin; Clinical Trials as Topic;	1975
Antibiotics in biliary disease: the relative importance of antibiotic concentrations in the bile and serum. Gut, 1976, Volume: 17, Issue:7 Topics: Anti-Bacterial Agents; Bile; Biliary Tract Diseases; Clinical Trials as Topic; Gentamicins; Humans;	1976
Antibiotic treatment of biliary sepsis. The Surgical clinics of North America, 1975, Volume: 55, Issue:6 Topics: Ampicillin; Anti-Bacterial Agents; Bile; Biliary Tract Diseases; Cholangitis; Cholecystectomy; Clini	1975
Ciprofloxacin versus gentamicin in prophylaxis against bacteremia in transrectal prostate needle biopsy. Urology, 1991, Volume: 38, Issue:1 Topics: Aged; Biopsy, Needle; Ciprofloxacin; Follow-Up Studies; Gentamicins; Humans; Male; Prostate; Rectum;	1991
Metabolic tolerance to arginine: implications for the safe use of arginine salt-aztreonam combination in the neonatal period. The Journal of pediatrics, 1991, Volume: 118, Issue:6 Topics: Ammonia; Ampicillin; Analysis of Variance; Arginine; Aztreonam; Bilirubin; Blood Glucose; Cohort Stu	1991
A comparative efficacy and safety study of teicoplanin plus aztreonam versus gentamicin plus piperacillin in haematology oncology patients with clinically diagnosed septicaemia. British journal of haematology, 1990, Volume: 76 Suppl 2 Topics: Adult; Anti-Bacterial Agents; Aztreonam; Bacteria; Drug Therapy, Combination; Female; Gentamicins; G	1990
Teicoplanin compared to flucloxacillin for antibiotic treatment of neutropenic patients. British journal of haematology, 1990, Volume: 76 Suppl 2 Topics: Anti-Bacterial Agents; Bacteria; Bone Marrow Transplantation; Drug Therapy, Combination; Fever; Flox	1990
[Ceftriaxone or combined cefazolin-gentamicin for complicated urinary tract infections]. Harefuah, 1990, Feb-01, Volume: 118, Issue:3 Topics: Aged; Cefazolin; Ceftriaxone; Drug Therapy, Combination; Female; Gentamicins; Humans; Israel; Male;	1990
Prophylactic one-dose treatment with clindamycin and gentamicin in transurethral prostatic resection. A double-blind placebo controlled study. Scandinavian journal of urology and nephrology, 1989, Volume: 23, Issue:2 Topics: Aged; Bacteriuria; Clindamycin; Double-Blind Method; Drug Therapy, Combination; Gentamicins; Humans;	1989
Cefotetan compared with gentamicin and tinidazole in acute abdominal surgery. The Journal of hospital infection, 1986, Volume: 7, Issue:1 Topics: Abdomen, Acute; Bacteria, Aerobic; Bacteria, Anaerobic; Bacteriuria; Cefotetan; Cephamycins; Enteroc	1986
Single dose intra-operative antimicrobial prophylaxis during prostatectomy: gentamicin compared with cefotetan. The Journal of hospital infection, 1986, Volume: 8, Issue:3 Topics: Bacteriuria; Cefotetan; Cephamycins; Gentamicins; Humans; Intraoperative Period; Male; Prostatectomy	1986
Randomized clinical trial of intra-operative antimicrobial prophylaxis of infection after neurosurgical procedures. The Journal of hospital infection, 1986, Volume: 8, Issue:3 Topics: Anti-Bacterial Agents; Bacterial Infections; Cerebrospinal Fluid Shunts; Clinical Trials as Topic; D	1986
Enzymuria in neonates during treatment with gentamicin or tobramycin. The Pediatric infectious disease journal, 1987, Volume: 6, Issue:9 Topics: Acetylglucosaminidase; Aminopeptidases; CD13 Antigens; Clinical Trials as Topic; Female; Gentamicins	1987
Susceptibility to beta-lactam antibiotics and gentamicin of gram-negative bacilli isolated from hospitalized patients: a Swedish multicenter study. Scandinavian journal of infectious diseases, 1988, Volume: 20, Issue:6 Topics: Ampicillin; Anti-Bacterial Agents; Bacteriuria; Drug Resistance, Microbial; Gentamicins; Gram-Negati	1988
Stratified duration of prophylactic antimicrobial treatment in emergency abdominal surgery. Metronidazole-fosfomycin vs. metronidazole-gentamicin in 381 patients. Acta chirurgica Scandinavica, 1987, Volume: 153, Issue:3 Topics: Abdomen, Acute; Adolescent; Adult; Aged; Appendicitis; Cholecystitis; Clinical Trials as Topic; Drug	1987
Comparison of cefotetan versus combination therapy in peritonitis and serious intra-abdominal sepsis. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl Topics: Aged; Cefotetan; Cephalosporins; Cephradine; Clinical Trials as Topic; Drug Therapy, Combination; Ge	1987
Antibiotic prophylaxis in surgery ranked by patients' risk rates. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl Topics: Aztreonam; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gentamicins; Hu	1987
Comparison of cefotetan and gentamicin/ampicillin in high-risk biliary tract surgery. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl Topics: Ampicillin; Biliary Tract Diseases; Cefotetan; Clinical Trials as Topic; Drug Therapy, Combination;	1987
Wound sepsis after colorectal surgery: the effect of cefotetan lavage. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl Topics: Bacteria, Aerobic; Bacteria, Anaerobic; Cefotetan; Clinical Trials as Topic; Colonic Diseases; Drug	1987
A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. The New England journal of medicine, 1986, Aug-28, Volume: 315, Issue:9 Topics: Adolescent; Adult; Aged; Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Carbenicillin	1986
Single dose antibiotic prophylaxis in high risk patients undergoing transurethral prostatectomy. The British journal of surgery, 1987, Volume: 74, Issue:3 Topics: Bacteriuria; Catheters, Indwelling; Clinical Trials as Topic; Gentamicins; Humans; Postoperative Com	1987
Stratified outcome comparison of clindamycin-gentamicin vs chloramphenicol-gentamicin for treatment of intra-abdominal sepsis. Archives of surgery (Chicago, Ill. : 1960), 1985, Volume: 120, Issue:8 Topics: Abdomen; Abscess; Adolescent; Adult; Aged; Bacteroides Infections; Chloramphenicol; Clindamycin; Cli	1985
A randomized trial of oral vancomycin in neutropenic patients. Progress in clinical and biological research, 1985, Volume: 181 Topics: Administration, Oral; Adolescent; Adult; Aged; Agranulocytosis; Antineoplastic Agents; Clinical Tria	1985
Endotracheal gentamicin for the prevention of bronchial infections in patients with tracheotomy. International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 7, Issue:4 Topics: Bacterial Infections; Bronchial Diseases; Clinical Trials as Topic; Drug Resistance, Microbial; Esch	1973
Clinical and laboratory studies with tobramycin. Chemotherapy, 1974, Volume: 20, Issue:4 Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Bacillus; Clinical Trials as Topic; Drug Synergism; E	1974
Therapy with carbenicillin and gentamicin for patients with cancer and severe infections caused by gram-negative rods. Cancer, 1973, Volume: 31, Issue:2 Topics: Bacteria; Bacterial Infections; Carbenicillin; Clinical Trials as Topic; Escherichia coli Infections	1973
Tobramycin: clinical and microbiological evaluation. International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 8, Issue:3 Topics: Aged; Aminoglycosides; Anti-Bacterial Agents; Arthritis; Bacteriuria; Biliary Tract Diseases; Clinic	1973
Antibacterial prophylaxis in prostatectomy patients. The Journal of urology, 1974, Volume: 111, Issue:6 Topics: Aged; Ampicillin; Anti-Bacterial Agents; Bacteriuria; Cephalosporins; Clinical Trials as Topic; Feve	1974
Pathogenesis and prevention of intravenous catheter infections. The Yale journal of biology and medicine, 1973, Volume: 46, Issue:2 Topics: Bacterial Infections; Benzalkonium Compounds; Catheterization; Clinical Trials as Topic; Gentamicins	1973
Phlebitis associated with cephalosporins: cephapirin versus cephalothin. Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:2 Topics: Acetamides; Anti-Infective Agents; Cellulitis; Cephalosporins; Cephalothin; Clinical Trials as Topic	1973
Gentamicin. Clinical and pharmacological studies. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 3, Issue:2 Topics: Acinetobacter Infections; Bacteroides Infections; Biliary Tract Diseases; Cellulitis; Clinical Trial	1970
The treatment of burns: a comparative trial of antibiotic dressings. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971, Feb-27, Volume: 45, Issue:9 Topics: Burns; Candida; Child; Child, Preschool; Escherichia coli; Framycetin; Gentamicins; Humans; Infant;	1971
Therapy with gentamicin for bacteremic infections: results with 53 patients. The Journal of infectious diseases, 1971, Volume: 124 Suppl Topics: Bacterial Infections; Drug Synergism; Endocarditis, Bacterial; Female; Gentamicins; Humans; Infectio	1971

gentamicin and Blood Poisoning

Research Excerpts

Research

Studies (683)

Authors

Clinical Trials (13)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Størdal, EH	1
Solevåg, AL	1
Bjørnholt, JV	1
Rønnestad, A	1
Stensvold, HJ	1
Akselsen, AB	1
Sheth, CC	1
Veses, V	1
Parker, SL	1
Irwin, AD	1
Hosking, F	1
August, D	1
Schoenmaker, B	1
Pandey, S	1
Wallis, SC	1
Lipman, J	2
Roberts, JA	3
Davies, MW	2
Obiero, CW	2
Williams, P	2
Murunga, S	2
Thitiri, J	2
Omollo, R	1
Walker, AS	1
Egondi, T	1
Nyaoke, B	2
Correia, E	2
Kane, Z	2
Gastine, S	2
Kipper, K	2
Standing, JF	2
Ellis, S	2
Sharland, M	4
Berkley, JA	3
Obiero, C	1
Readman, J	1
van den Anker, J	1
Petejova, N	4
Martinek, A	4
Zadrazil, J	2