gentamicin has been researched along with Ataxia Telangiectasia in 2 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamura, K | 1 |
| Du, L | 2 |
| Tunuguntla, R | 1 |
| Fike, F | 1 |
| Cavalieri, S | 1 |
| Morio, T | 1 |
| Mizutani, S | 1 |
| Brusco, A | 1 |
| Gatti, RA | 2 |
| Lai, CH | 1 |
| Chun, HH | 1 |
| Nahas, SA | 1 |
| Mitui, M | 1 |
| Gamo, KM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-protocol is Identical to Study No. 0519-10-TLV- Minors' Adjusted Version[NCT02354560] | Phase 4 | 15 participants (Anticipated) | Interventional | 2015-06-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for gentamicin and Ataxia Telangiectasia
| Article | Year |
|---|---|
Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxia-telangiectasia.
Topics: Aminoglycosides; Asian People; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Base S | 2012 |
Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.
Topics: Aminoglycosides; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Base Sequence; Cell | 2004 |