gentamicin has been researched along with Alloxan Diabetes in 22 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF)." | 7.67 | Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. ( Alpert, HC; Gouvea, WL; Kelley, J; Pardo, V; Vaamonde, CA, 1989) |
| "The influence of hyperfiltration-hypertrophy, proteinuria and glucosuria on the renal cortical uptake of gentamicin was studied in several experimental models." | 7.67 | Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats. ( De Broe, ME; Giuliano, RA; Pattyn, VM; Verpooten, GA; Zheng, F, 1988) |
| "Systemic bacterial infections due to Escherichia coli MB 2884, Proteus mirabilis MB 3125 and Klebsiella pneumoniae MB 4005 were well controlled by treatment with norfloxacin both in normal and streptozotocin-induced diabetic mice." | 3.67 | Antibacterial efficacy of norfloxacin, trimethoprim-sulfamethoxazole, and gentamicin in experimentally-infected normal and streptozotocin-induced diabetic mice. ( Abruzzo, GK; Fromtling, RA; Gadebusch, HH, 1984) |
| "Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF)." | 3.67 | Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. ( Alpert, HC; Gouvea, WL; Kelley, J; Pardo, V; Vaamonde, CA, 1989) |
| "The influence of hyperfiltration-hypertrophy, proteinuria and glucosuria on the renal cortical uptake of gentamicin was studied in several experimental models." | 3.67 | Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats. ( De Broe, ME; Giuliano, RA; Pattyn, VM; Verpooten, GA; Zheng, F, 1988) |
| "Gentamicin induced increase in lipid peroxides, decrease in glutathione and activities of antioxidant enzymes in the kidney, and increase in blood creatinine, and urea concentrations were significantly countered by nigerloxin treatment." | 1.40 | Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats. ( Srinivasan, K; Suresha, BS, 2014) |
| "Gentamicin treatment caused an elevation in serum urea and creatinine concentrations and ALT activity, associated with pathological changes in the liver and kidney." | 1.28 | Comparison of gentamicin toxicity in normal and diabetic rats. ( Arbid, MS; Atef, M; Hanafy, MS, 1992) |
| " Pharmacokinetic studies in mice showed a linear dose response in serum after the 20 and 50 mg/kg subcutaneous dose and urinary recoveries of administered dose of about 60% in 6 hours." | 1.28 | L-658,310, a new injectable cephalosporin. III. Experimental chemotherapeutics and pharmacokinetics in laboratory animals. ( Abruzzo, GK; Bland, JA; Fromtling, RA; Gadebusch, HH; Gilfillan, EC; Hadley, SK; Pelak, BA; Weissberger, BA, 1989) |
| "Gentamicin was administered at 40 mg/kg-day to C and C/I and 32 mg/kg-day to DM rats to adjust for base-line CIN." | 1.27 | Experimental gentamicin nephrotoxicity: effect of streptozotocin-induced diabetes. ( Baines-Hunter, J; Bennett, WM; Elliott, WC; Gilbert, DN; Houghton, DC, 1985) |
| " To test this hypothesis we injected DM rats with saline or with gentamicin, 100, 200, and 400 mg/kg per day for 6 days, to determine if the renal cortical concentration of gentamicin could be raised to toxic levels." | 1.27 | Induction of nephrotoxicity by high doses of gentamicin in diabetic rats. ( Jones, D; Josepovitz, C; Kaloyanides, GJ; Lane, BP; Ling, KY; Ramsammy, LS, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Papadopoulou, V | 1 |
| Sidders, AE | 1 |
| Lu, KY | 1 |
| Velez, AZ | 1 |
| Durham, PG | 1 |
| Bui, DT | 1 |
| Angeles-Solano, M | 1 |
| Dayton, PA | 1 |
| Rowe, SE | 1 |
| Dwivedi, C | 1 |
| Pandey, I | 1 |
| Pandey, H | 1 |
| Patil, S | 1 |
| Mishra, SB | 1 |
| Pandey, AC | 1 |
| Zamboni, P | 1 |
| Ramteke, PW | 1 |
| Singh, AV | 1 |
| Martins, ALCL | 1 |
| Watanabe, M | 1 |
| Fernandes, SM | 1 |
| Fonseca, CDD | 1 |
| Vattimo, MFF | 1 |
| Suresha, BS | 1 |
| Srinivasan, K | 1 |
| Fromtling, RA | 2 |
| Abruzzo, GK | 2 |
| Gadebusch, HH | 2 |
| Vaamonde, CA | 5 |
| Bier, RT | 1 |
| Gouvea, W | 3 |
| Alpert, H | 4 |
| Kelley, J | 4 |
| Pardo, V | 5 |
| Teixeira, RB | 1 |
| Roth, D | 1 |
| Dehpour, AR | 1 |
| Samadian, T | 1 |
| Rassaee, N | 1 |
| Martinez, BB | 1 |
| Marumo, CK | 1 |
| Leão, CS | 1 |
| Silva, RR | 1 |
| Costa-Silva, VL | 1 |
| Zaladek-Gil, F | 1 |
| Ali, BH | 1 |
| Bashir, AK | 1 |
| Mugamer, IT | 1 |
| Tanira, MO | 1 |
| Tamada, J | 1 |
| Langer, R | 1 |
| Vaamonde, CM | 1 |
| Owens, B | 1 |
| Atef, M | 1 |
| Arbid, MS | 1 |
| Hanafy, MS | 1 |
| Brown, SA | 1 |
| Nelson, RW | 1 |
| Scott-Moncrieff, C | 1 |
| Gilfillan, EC | 1 |
| Pelak, BA | 1 |
| Weissberger, BA | 1 |
| Bland, JA | 1 |
| Hadley, SK | 1 |
| Gouvea, WL | 1 |
| Alpert, HC | 1 |
| Elliott, WC | 1 |
| Houghton, DC | 1 |
| Gilbert, DN | 1 |
| Baines-Hunter, J | 1 |
| Bennett, WM | 1 |
| Pattyn, VM | 1 |
| Verpooten, GA | 1 |
| Giuliano, RA | 1 |
| Zheng, F | 1 |
| De Broe, ME | 1 |
| Ramsammy, LS | 1 |
| Josepovitz, C | 2 |
| Jones, D | 1 |
| Ling, KY | 1 |
| Lane, BP | 1 |
| Kaloyanides, GJ | 2 |
| Shyh, TP | 1 |
| Shieh, SD | 1 |
| Huang, HW | 1 |
| Levine, R | 1 |
| Farruggella, T | 1 |
| Lane, B | 1 |
1 review available for gentamicin and Alloxan Diabetes
| Article | Year |
|---|---|
The development of polyanhydrides for drug delivery applications.
Topics: Alzheimer Disease; Anhydrides; Animals; Bethanechol; Bethanechol Compounds; Biocompatible Materials; | 1992 |
1 trial available for gentamicin and Alloxan Diabetes
| Article | Year |
|---|---|
The development of polyanhydrides for drug delivery applications.
Topics: Alzheimer Disease; Anhydrides; Animals; Bethanechol; Bethanechol Compounds; Biocompatible Materials; | 1992 |
21 other studies available for gentamicin and Alloxan Diabetes
| Article | Year |
|---|---|
Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Biofilms; Diabetes Mellitus, Experimental; Gentamic | 2023 |
In vivo diabetic wound healing with nanofibrous scaffolds modified with gentamicin and recombinant human epidermal growth factor.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Delayed-Action Preparations; Diabetes Mellitus, Experiment | 2018 |
Diabetes Mellitus: a risk factor for drug toxicity.
Topics: Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Gentamicins; Kidney Diseases; Kidne | 2018 |
Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.
Topics: Aldehyde Reductase; Animals; Anti-Bacterial Agents; Aspergillus niger; Benzoates; Blood Glucose; Cre | 2014 |
Antibacterial efficacy of norfloxacin, trimethoprim-sulfamethoxazole, and gentamicin in experimentally-infected normal and streptozotocin-induced diabetic mice.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Diabetes Mellitus, Experimental; Dru | 1984 |
Effect of duration of diabetes on the protection observed in the diabetic rat against gentamicin-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Body Weight; Diabetes Mellitus, Experimental; Drinking; Feeding Behavi | 1984 |
Complete protection from gentamicin-induced acute renal failure in the diabetes mellitus rat.
Topics: Acute Kidney Injury; Animals; Diabetes Insipidus; Diabetes Mellitus, Experimental; Female; Gentamici | 1982 |
Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat.
Topics: Animals; Body Weight; Creatine; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Hy | 1994 |
Diabetic rats show more resistance to neuromuscular blockade induced by aminoglycoside antibiotics.
Topics: Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Drug Resistance; Female; Gentamicin | 1993 |
Renal effect of gentamicin in diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Gentamicins; | 1995 |
Gentamicin nephrotoxicity in the rat: influence of age and diabetes mellitus.
Topics: Aging; Animals; Anti-Bacterial Agents; Body Weight; Copper; Diabetes Mellitus, Experimental; Gentami | 1996 |
The protection against gentamicin nephrotoxicity in the streptozotocin-induced diabetic rat is not related to gender.
Topics: Animals; Creatinine; Diabetes Mellitus, Experimental; Female; Gentamicins; Glomerular Filtration Rat | 1992 |
Comparison of gentamicin toxicity in normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Gentamicins; Male; Rats | 1992 |
Gentamicin pharmacokinetics in diabetic dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dog Diseases; Dogs; Gentamicins; Injections, Intravenous; | 1991 |
L-658,310, a new injectable cephalosporin. III. Experimental chemotherapeutics and pharmacokinetics in laboratory animals.
Topics: Animals; Bacterial Infections; Ceftazidime; Cephalosporins; Diabetes Mellitus, Experimental; Drug Re | 1989 |
Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Kidn | 1989 |
Experimental gentamicin nephrotoxicity: effect of streptozotocin-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diuresis; Gentamicins; Isosorbide; Kidney; Kidney Cortex; | 1985 |
Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Gentamicins; Glomerular Filtration Rate; Hypertrop | 1988 |
Induction of nephrotoxicity by high doses of gentamicin in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fatty Acids; Gentamicins | 1987 |
Induced hyperglycemia protects rats against gentamicin nephrotoxicity.
Topics: Animals; Diabetes Mellitus, Experimental; Gentamicins; Kidney; Male; Nephrectomy; Rats; Rats, Inbred | 1987 |
[3H]netilmicin binding constants and phospholipid composition of renal plasma membranes of normal and diabetic rats.
Topics: Animals; Binding Sites; Cell Membrane; Diabetes Mellitus, Experimental; Gentamicins; In Vitro Techni | 1985 |