gentamicin has been researched along with Aging in 53 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Reactive oxygen species contribute to the formation of several types of cochlear injuries, including age-related hearing loss and gentamicin ototoxicity." | 7.77 | Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. ( Hara, A; Hoshino, T; Ishii, T; Nakayama, M; Nishimura, B; Shimizu, R; Tabuchi, K; Tanaka, S; Warabi, E; Yamamoto, M; Yanagawa, T, 2011) |
| "To evaluate an existing once-daily gentamicin dosing guideline in children with febrile neutropenia resulting from antineoplastic therapy and, if necessary, to develop a new simulated dosing guideline that would achieve pharmacokinetic targets more reliably after the first dose." | 7.76 | Once-daily gentamicin dosing in children with febrile neutropenia resulting from antineoplastic therapy. ( Atenafu, EG; Boodhan, S; Dupuis, LL; Inparajah, M; Naqvi, A; Sibbald, C; Wong, C, 2010) |
| "The pharmacokinetic parameters of gentamicin and tobramycin were evaluated and compared for 260 patients with pleural effusions and 1,049 patients without pleural effusions by chest radiograph." | 7.68 | Variation in the pharmacokinetics of gentamicin and tobramycin in patients with pleural effusions and hypoalbuminemia. ( Bertino, JS; Etzel, JV; Nafziger, AN, 1992) |
| "The effects of aging on gentamicin total-body clearance, volume of distribution, and half-life were examined in 173 febrile patients with gram-negative infections." | 7.66 | Gentamicin pharmacokinetics: effect of aging in patients with normal renal function. ( Bauer, LA; Blouin, RA, 1982) |
| " To investigate whether the sensitivity of the old kidney to gentamicin is a function of age, separate from the adverse effects arising from declining renal excretory function, the nephrotoxicity of 12 daily injections of this antibiotic was measured in rats." | 5.26 | Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rats. ( Engel, SG; McMartin, DN, 1982) |
| "To determine the incidence of acute kidney injury (AKI) in aged patients receiving empiric gentamicin therapy." | 3.88 | Renal safety of short-term empiric gentamicin therapy in aged patients. ( Adler, NR; Ananda-Rajah, MR; Aung, AK; Liew, D; Sia, CS; Tong, EY; Yi-Wei, B, 2018) |
| " Reactive oxygen species contribute to the formation of several types of cochlear injuries, including age-related hearing loss and gentamicin ototoxicity." | 3.77 | Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. ( Hara, A; Hoshino, T; Ishii, T; Nakayama, M; Nishimura, B; Shimizu, R; Tabuchi, K; Tanaka, S; Warabi, E; Yamamoto, M; Yanagawa, T, 2011) |
| "To evaluate an existing once-daily gentamicin dosing guideline in children with febrile neutropenia resulting from antineoplastic therapy and, if necessary, to develop a new simulated dosing guideline that would achieve pharmacokinetic targets more reliably after the first dose." | 3.76 | Once-daily gentamicin dosing in children with febrile neutropenia resulting from antineoplastic therapy. ( Atenafu, EG; Boodhan, S; Dupuis, LL; Inparajah, M; Naqvi, A; Sibbald, C; Wong, C, 2010) |
| "The pharmacokinetic parameters of gentamicin and tobramycin were evaluated and compared for 260 patients with pleural effusions and 1,049 patients without pleural effusions by chest radiograph." | 3.68 | Variation in the pharmacokinetics of gentamicin and tobramycin in patients with pleural effusions and hypoalbuminemia. ( Bertino, JS; Etzel, JV; Nafziger, AN, 1992) |
| "The effect of aging on the total body clearance, volume of distribution, and half-life of gentamicin was examined in 99 febrile patients with various degrees of renal function." | 3.67 | Gentamicin disposition in young and elderly patients with various degrees of renal function. ( Halstenson, CE; Jameson, JJ; Matzke, GR, 1987) |
| " The excretion of this protein was compared to the excretion of the enzyme beta-N-acetyl-D-glucosaminidase (NAG), albumin and amino acids in rats treated with either a single dose of sodium chromate (5 and 10 mg kg-1), repeated doses of gentamicin (5 and 20 mg kg-1), or cadmium (1 mg kg-1), and in aging rats (from 2 to 20 months)." | 3.67 | Determination of rat beta 2-microglobulin in urine and in serum. II. Application of its urinary measurement to selected nephrotoxicity models. ( Bernard, A; Lauwerys, R; Ouled, A; Viau, C, 1986) |
| "Serum gentamicin concentration was measured in 31 newborn babies who received oral gentamicin for prophylaxis of necrotizing enterocolitis in order to determine the presence and degree of gastrointestinal absorption and its relationship to birth weight, gestational age, postnatal age and perinatal asphyxia." | 3.66 | Serum concentrations of gentamicin following oral administration to preterm newborns. ( Boehnert, J; Grylack, L; Scanlon, J, 1982) |
| "The effects of aging on gentamicin total-body clearance, volume of distribution, and half-life were examined in 173 febrile patients with gram-negative infections." | 3.66 | Gentamicin pharmacokinetics: effect of aging in patients with normal renal function. ( Bauer, LA; Blouin, RA, 1982) |
| " The pharmacokinetics of this dosage in foals and the ages at which this higher dose should be used have not previously been investigated." | 2.78 | Effect of age on the pharmacokinetics of a single daily dose of gentamicin sulfate in healthy foals. ( Alhamhoom, Y; Arnold, RD; Burton, AJ; Giguère, S; Warner, L, 2013) |
| " the number of dosing intervals) and to compare the number of serum concentrations outside the therapeutic range as an indicator of potential toxicity between the treatment groups." | 2.68 | Prospective, randomized, controlled evaluation of a gentamicin loading dose in neonates. ( Sankaran, K; Semchuk, W; Shevchuk, YM; Wallace, SM, 1995) |
| "This study retrospectively characterized population-based pharmacokinetic parameters for gentamicin in neonates and young infants, and evaluated the predictive performance of these parameters in a Bayesian forecasting program." | 2.67 | Prediction of gentamicin concentrations in neonates and infants using a Bayesian pharmacokinetic model. ( Gentry, CA; Gross, JR; Kraus, DM; Nickel, E; Plank, GS; Rodvold, KA, 1993) |
| " Gentamicin dosing guidelines have been developed over the past 20 years to accommodate a slower renal elimination rate of gentamicin in the neonatal population." | 2.67 | Determination of a gentamicin loading dose in neonates and infants. ( Borgmann, J; Bowman, L; Semchuk, W, 1993) |
| "Isepamicin is an aminoglycoside antibacterial with properties similar to those of amikacin, but with better activity against strains producing type I 6'-acetyltransferase." | 2.41 | Clinical pharmacokinetics and pharmacodynamics of isepamicin. ( Padoin, C; Petitjean, O; Tod, M, 2000) |
| " However, there appears to be no published data describing detrimental or beneficial pharmacokinetic interactions between gentamicin and drugs used in the elderly." | 2.40 | Pharmacokinetics and therapeutic drug monitoring of gentamicin in the elderly. ( Charles, B; Triggs, E, 1999) |
| "Sisomicin is a naturally occurring aminoglycoside antibiotic produced by Micromonospora inyoensis, while dibekacin and netilmicin are both semisynthetic aminoglycosides." | 2.37 | Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use. ( Noone, P, 1984) |
| " Diminished renal function and activity of some hepatic enzymes alter the half-lives of various drugs, making extrapolation from adult dosage impossible." | 2.36 | Antimicrobial therapy and the neonate. ( Yaffe, SJ, 1981) |
| "A one-compartment linear pharmacokinetic model best described the data and the addition of frailty to the model reduced the random variability in gentamicin clearance by 12 % after adjustment for renal function (estimated creatinine clearance using lean body weight) and lean body weight." | 1.40 | The impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration. ( Carroll, PR; Hilmer, SN; Johnston, C; Kirkpatrick, CM; Matthews, ST; McLachlan, AJ, 2014) |
| "In the pharmacokinetic analysis (NONMEM VI) based on data of gentamicin, tobramycin and vancomycin collected in 1,760 patients (age 1 day-18 years, bodyweight 415 g-85 kg), a distinction was made between drug-specific and system-specific information." | 1.40 | Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration. ( Allegaert, K; Brussee, JM; Danhof, M; De Cock, RF; de Hoog, M; Knibbe, CA; Mulla, H; Sherwin, CM; van den Anker, JN, 2014) |
| "One hundred fourteen non-critical care pediatric patients older than 3 months of age without cystic fibrosis who received multiple-daily dosing regimens of gentamicin between September 2007 and April 2008." | 1.36 | Once-daily gentamicin dosing in pediatric patients without cystic fibrosis. ( McDade, EJ; Moffett, BS; Palazzi, DL; Wagner, JL, 2010) |
| " Since differentiating cells and developing tissues may exhibit different degrees of sensitivity to toxic drugs, we aimed here to test the susceptibility of the developing mammalian retina to the toxic action of gentamicin." | 1.35 | The developing mammalian retina is partially protected from gentamicin toxicity. ( Loewenstein, A; Perlman, I; Soudry, S; Zemel, E, 2009) |
| "Aminoglycoside demographic, dosing and concentration data were collected from 697 adult patients (> or =20 years old) as part of standard clinical care using a target concentration intervention approach for dose individualization." | 1.32 | Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides. ( Holford, N; Kirkpatrick, C; Matthews, I, 2004) |
| "Gentamicin (3 mg/kg, iv) was administered 24 hours after an endotoxin challenge (5 mg/kg, ip)." | 1.30 | Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats. ( Ali, BH; Bashir, AK; Tanira, MO, 1997) |
| "Gentamicin treatment (80 dB threshold shift at 18 kHz) and noise exposure (43 dB threshold shift at 18 kHz) did not affect glutathione at the tissue level." | 1.30 | Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise. ( Crann, SA; Lautermann, J; McLaren, J; Schacht, J, 1997) |
| "5, 1, 4, 6, 8 and 12 hours after the initiation of dosing and at 0." | 1.29 | Pharmacokinetics of isepamicin in paediatric patients. ( Affrime, M; Colucci, R; Cutler, D; Elliott, M; Guerciolini, R; Lin, CC; Radwanski, E; Scaglione, F; Viganò, A; Zampaglione, N, 1995) |
| "Necropsy revealed brain abscesses with Escherichia Coli in pure culture." | 1.29 | Meningoencephalitis and brain abscessation due to Escherichia coli in a 2 week old alpaca cria. ( Dvir, I; Harmelin, A; Tsur, I; Yanai, J, 1996) |
| "Gentamicin pharmacokinetics and the predictive performance of the Sawchuk-Zaske dosing method for gentamicin were compared in elderly and young patients with stable normal serum creatinine concentrations." | 1.28 | Accuracy of pharmacokinetic dose determination of gentamicin in geriatric patients. ( Birge, S; Lackner, TE, 1990) |
| "The effect of age and renal function on gentamicin pharmacokinetic parameters were studied in 125 patients with various degrees of renal function." | 1.28 | Effect of age and renal function on gentamicin pharmacokinetic parameters. ( el-Sayed, YM; Islam, SI, 1989) |
| " On the basis of the kinetic data, a satisfactory intramuscular dosage regimen for gentamicin sulphate would be at least 6 mg kg-1 body weight repeated at 8 h intervals." | 1.28 | Disposition kinetics and urinary excretion of gentamicin in buffalo bulls (Bubalus bubalis). ( Garg, BD; Garg, SK, 1989) |
| " These population mean parameter estimates were used to generate dosage regimens to achieve concentrations within the therapeutic range." | 1.27 | Population pharmacokinetics of gentamicin in neonates. ( Bryson, SM; Kelman, AW; McGovern, EM; Thomson, AH; Way, S; Whiting, B, 1988) |
| "Gentamicin was administered subcutaneously to sexually immature (1400 to 1800 gm) or sexually mature (3800 to 4600 gm) New Zealand White rabbits in a dose of 15 mg/kg twice a day." | 1.27 | Effect of gentamicin on isolated glomeruli and proximal tubules of the rabbit. ( Chonko, A; Cuppage, F; Hodges, G; Karniski, L; Savin, V, 1985) |
| " To investigate whether the sensitivity of the old kidney to gentamicin is a function of age, separate from the adverse effects arising from declining renal excretory function, the nephrotoxicity of 12 daily injections of this antibiotic was measured in rats." | 1.26 | Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rats. ( Engel, SG; McMartin, DN, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (43.40) | 18.7374 |
| 1990's | 18 (33.96) | 18.2507 |
| 2000's | 4 (7.55) | 29.6817 |
| 2010's | 8 (15.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sia, CS | 1 |
| Ananda-Rajah, MR | 1 |
| Adler, NR | 1 |
| Yi-Wei, B | 1 |
| Liew, D | 1 |
| Tong, EY | 1 |
| Aung, AK | 1 |
| Naqi, SA | 1 |
| Sahin, N | 1 |
| Wagner, G | 1 |
| Williams, J | 1 |
| Johnston, C | 1 |
| Hilmer, SN | 1 |
| McLachlan, AJ | 1 |
| Matthews, ST | 1 |
| Carroll, PR | 1 |
| Kirkpatrick, CM | 1 |
| De Cock, RF | 1 |
| Allegaert, K | 1 |
| Brussee, JM | 1 |
| Sherwin, CM | 1 |
| Mulla, H | 1 |
| de Hoog, M | 1 |
| van den Anker, JN | 1 |
| Danhof, M | 1 |
| Knibbe, CA | 1 |
| Soudry, S | 1 |
| Zemel, E | 1 |
| Loewenstein, A | 1 |
| Perlman, I | 1 |
| Espandiari, P | 1 |
| Rosenzweig, B | 1 |
| Zhang, J | 1 |
| Zhou, Y | 1 |
| Schnackenberg, L | 1 |
| Vaidya, VS | 1 |
| Goering, PL | 1 |
| Brown, RP | 1 |
| Bonventre, JV | 1 |
| Mahjoob, K | 1 |
| Holland, RD | 1 |
| Beger, RD | 1 |
| Thompson, K | 1 |
| Hanig, J | 1 |
| Sadrieh, N | 1 |
| Inparajah, M | 1 |
| Wong, C | 1 |
| Sibbald, C | 1 |
| Boodhan, S | 1 |
| Atenafu, EG | 1 |
| Naqvi, A | 1 |
| Dupuis, LL | 1 |
| McDade, EJ | 1 |
| Wagner, JL | 1 |
| Moffett, BS | 1 |
| Palazzi, DL | 1 |
| Hoshino, T | 1 |
| Tabuchi, K | 1 |
| Nishimura, B | 1 |
| Tanaka, S | 1 |
| Nakayama, M | 1 |
| Ishii, T | 1 |
| Warabi, E | 1 |
| Yanagawa, T | 1 |
| Shimizu, R | 1 |
| Yamamoto, M | 1 |
| Hara, A | 1 |
| Burton, AJ | 1 |
| Giguère, S | 1 |
| Warner, L | 1 |
| Alhamhoom, Y | 1 |
| Arnold, RD | 1 |
| Shou, J | 1 |
| Zheng, JL | 1 |
| Gao, WQ | 1 |
| Matthews, I | 1 |
| Kirkpatrick, C | 1 |
| Holford, N | 1 |
| Terata, N | 1 |
| Tanio, Y | 1 |
| Zbar, B | 1 |
| Noone, P | 1 |
| Yaffe, SJ | 1 |
| Bauer, LA | 1 |
| Blouin, RA | 1 |
| McDowell, B | 1 |
| Grylack, L | 1 |
| Boehnert, J | 1 |
| Scanlon, J | 1 |
| Weismann, D | 1 |
| Herrig, J | 1 |
| McWeeny, O | 1 |
| McMartin, DN | 1 |
| Engel, SG | 1 |
| Hallynck, T | 1 |
| Pijck, J | 1 |
| Soep, H | 1 |
| Hallynck, TH | 1 |
| Soep, HH | 1 |
| Thomis, JA | 1 |
| Boelaert, J | 1 |
| Daneels, R | 1 |
| Dettli, L | 1 |
| Semchuk, W | 2 |
| Shevchuk, YM | 1 |
| Sankaran, K | 1 |
| Wallace, SM | 1 |
| Bhave, SA | 1 |
| Stone, JS | 1 |
| Rubel, EW | 1 |
| Coltrera, MD | 1 |
| Rodvold, KA | 1 |
| Gentry, CA | 1 |
| Plank, GS | 1 |
| Kraus, DM | 1 |
| Nickel, E | 1 |
| Gross, JR | 1 |
| Borgmann, J | 1 |
| Bowman, L | 1 |
| Warchol, ME | 1 |
| Lambert, PR | 1 |
| Goldstein, BJ | 1 |
| Forge, A | 1 |
| Corwin, JT | 1 |
| Scaglione, F | 1 |
| Viganò, A | 1 |
| Colucci, R | 1 |
| Zampaglione, N | 1 |
| Lin, CC | 1 |
| Cutler, D | 1 |
| Guerciolini, R | 1 |
| Elliott, M | 1 |
| Affrime, M | 1 |
| Radwanski, E | 1 |
| Ali, BH | 2 |
| Bashir, AK | 2 |
| Mugamer, IT | 1 |
| Tanira, MO | 2 |
| Murphy, JE | 1 |
| Severnak, T | 1 |
| Russell, P | 1 |
| Johnson, DH | 1 |
| Tsur, I | 1 |
| Harmelin, A | 1 |
| Dvir, I | 1 |
| Yanai, J | 1 |
| Lautermann, J | 1 |
| Crann, SA | 1 |
| McLaren, J | 1 |
| Schacht, J | 1 |
| Lopez-Gonzalez, MA | 1 |
| Delgado, F | 1 |
| Lucas, M | 1 |
| Triggs, E | 1 |
| Charles, B | 1 |
| Tod, M | 1 |
| Padoin, C | 1 |
| Petitjean, O | 1 |
| Klein, J | 2 |
| Koren, G | 2 |
| MacLeod, SM | 2 |
| Clarke, CR | 1 |
| Lochner, FK | 1 |
| Bellamy, J | 1 |
| Etzel, JV | 1 |
| Nafziger, AN | 1 |
| Bertino, JS | 1 |
| Lackner, TE | 1 |
| Birge, S | 1 |
| el-Sayed, YM | 1 |
| Islam, SI | 1 |
| Beauchamp, D | 1 |
| Gourde, P | 1 |
| Bergeron, MG | 1 |
| Garg, SK | 1 |
| Garg, BD | 1 |
| Thomson, AH | 1 |
| Way, S | 1 |
| Bryson, SM | 1 |
| McGovern, EM | 1 |
| Kelman, AW | 1 |
| Whiting, B | 1 |
| Higa, GM | 1 |
| Murray, WE | 1 |
| Viau, C | 1 |
| Bernard, A | 1 |
| Ouled, A | 1 |
| Lauwerys, R | 1 |
| Matzke, GR | 1 |
| Jameson, JJ | 1 |
| Halstenson, CE | 1 |
| Buchanan, JH | 1 |
| Sidhu, J | 1 |
| Savin, V | 1 |
| Karniski, L | 1 |
| Cuppage, F | 1 |
| Hodges, G | 1 |
| Chonko, A | 1 |
| Kasik, JW | 1 |
| Jenkins, S | 1 |
| Leuschen, MP | 1 |
| Nelson, RM | 1 |
| Bunn, PA | 1 |
4 reviews available for gentamicin and Aging
| Article | Year |
|---|---|
Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use.
Topics: Aging; Animals; Bacterial Infections; Dibekacin; Drug Interactions; Drug Resistance, Microbial; Drug | 1984 |
Antimicrobial therapy and the neonate.
Topics: Absorption; Aging; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Biological Availabi | 1981 |
Pharmacokinetics and therapeutic drug monitoring of gentamicin in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Anti-Infective Agents; Drug Monitoring; Gentamicins; Humans | 1999 |
Clinical pharmacokinetics and pharmacodynamics of isepamicin.
Topics: Adult; Aging; Animals; Anti-Bacterial Agents; Child; Gentamicins; Humans; Infant, Newborn; Injection | 2000 |
6 trials available for gentamicin and Aging
| Article | Year |
|---|---|
Adverse effects of antibiotics on the development of gut-associated lymphoid tissues and the serum immunoglobulins in chickens.
Topics: Aging; Animals; Anti-Bacterial Agents; Chickens; Gastrointestinal Tract; Gentamicins; Immunoglobulin | 1984 |
Effect of age on the pharmacokinetics of a single daily dose of gentamicin sulfate in healthy foals.
Topics: Aging; Animals; Animals, Newborn; Anti-Bacterial Agents; Area Under Curve; Body Fluids; Chromatograp | 2013 |
Prospective, randomized, controlled evaluation of a gentamicin loading dose in neonates.
Topics: Aging; Birth Weight; Creatinine; Dose-Response Relationship, Drug; Female; Gentamicins; Gestational | 1995 |
Prediction of gentamicin concentrations in neonates and infants using a Bayesian pharmacokinetic model.
Topics: Aging; Bayes Theorem; Creatinine; Female; Gentamicins; Humans; Infant; Infant, Newborn; Male; Models | 1993 |
Determination of a gentamicin loading dose in neonates and infants.
Topics: Aging; Dose-Response Relationship, Drug; Gentamicins; Half-Life; Humans; Infant; Infant, Newborn; Re | 1993 |
Gentamicin pharmacokinetics in Native Americans of Apache ancestry.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anti-Bacterial Agents; Body Weight; Female; Genta | 1996 |
43 other studies available for gentamicin and Aging
| Article | Year |
|---|---|
Renal safety of short-term empiric gentamicin therapy in aged patients.
Topics: Acute Kidney Injury; Age Factors; Aged; Aged, 80 and over; Aging; Anti-Bacterial Agents; Biomarkers; | 2018 |
The impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration.
Topics: Aged; Aged, 80 and over; Aging; Female; Frail Elderly; Gentamicins; Glomerular Filtration Rate; Huma | 2014 |
Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration.
Topics: Adolescent; Adult; Aging; Body Weight; Child; Child, Preschool; Creatinine; Gentamicins; Glomerular | 2014 |
The developing mammalian retina is partially protected from gentamicin toxicity.
Topics: Adaptation, Ocular; Age Factors; Aging; Animals; Anti-Bacterial Agents; Electroretinography; Gentami | 2009 |
Age-related differences in susceptibility to cisplatin-induced renal toxicity.
Topics: Age Factors; Aging; Animals; Biomarkers; Child; Cisplatin; Disease Susceptibility; Gentamicins; Huma | 2010 |
Once-daily gentamicin dosing in children with febrile neutropenia resulting from antineoplastic therapy.
Topics: Adolescent; Aging; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Child; Child, Preschoo | 2010 |
Once-daily gentamicin dosing in pediatric patients without cystic fibrosis.
Topics: Adolescent; Aging; Anti-Bacterial Agents; Child; Child, Preschool; Drug Administration Schedule; Gen | 2010 |
Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity.
Topics: Aging; Animals; Anti-Bacterial Agents; Ear, Inner; Gene Expression Regulation, Developmental; Gentam | 2011 |
Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1.
Topics: Adenoviridae; Aging; Aminoglycosides; Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcriptio | 2003 |
Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides.
Topics: Adult; Aged; Aging; Aminoglycosides; Anti-Bacterial Agents; Body Weight; Creatinine; Female; Gentami | 2004 |
A reliable method for reconstituting thymectomized, lethally irradiated guinea pigs with bone marrow cells.
Topics: Aging; Animals; Bone Marrow; Bone Marrow Transplantation; Dose-Response Relationship, Immunologic; G | 1984 |
Gentamicin pharmacokinetics: effect of aging in patients with normal renal function.
Topics: Adult; Aged; Aging; Bacterial Infections; Female; Gentamicins; Humans; Kidney; Male; Middle Aged | 1982 |
Patterns of cochlear degeneration following gentamicin administration in both old and young guinea pigs.
Topics: Aging; Animals; Cochlea; Female; Gentamicins; Guinea Pigs; Hair Cells, Auditory; Hair Cells, Auditor | 1982 |
Serum concentrations of gentamicin following oral administration to preterm newborns.
Topics: Administration, Oral; Aging; Asphyxia Neonatorum; Birth Weight; Enterocolitis, Pseudomembranous; Gen | 1982 |
Tissue distribution of gentamicin in lambs: effect of postnatal age and acute hypoxemia.
Topics: Aging; Animals; Blood Gas Analysis; Gentamicins; Hematocrit; Hypoxia; Regional Blood Flow; Sheep; Ti | 1982 |
Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rats.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Enzymes; Gentamicins; Kidney; Kidney Tubules; Kine | 1982 |
Influence of age and lean body mass on the relation of creatinine clearance and drug half-life.
Topics: Adolescent; Aging; Amikacin; Body Weight; Child; Child, Preschool; Creatinine; Female; Gentamicins; | 1982 |
Should clearance be normalised to body surface or to lean body mass?
Topics: Aging; Body Surface Area; Body Weight; Child; Child, Preschool; Creatinine; Female; Gentamicins; Hal | 1981 |
Cell cycle progression in gentamicin-damaged avian cochleas.
Topics: Aging; Animals; Bromodeoxyuridine; Cell Cycle; Chick Embryo; Chickens; Cochlea; Gentamicins; Immunoh | 1995 |
Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.
Topics: Adult; Aging; Animals; Autoradiography; Bromodeoxyuridine; Cell Division; Cells, Cultured; DNA Repli | 1993 |
Pharmacokinetics of isepamicin in paediatric patients.
Topics: Adolescent; Aging; Anti-Bacterial Agents; Child; Child, Preschool; Gentamicins; Humans; Infant; Infa | 1995 |
Gentamicin nephrotoxicity in the rat: influence of age and diabetes mellitus.
Topics: Aging; Animals; Anti-Bacterial Agents; Body Weight; Copper; Diabetes Mellitus, Experimental; Gentami | 1996 |
Enzymes protective of oxidative damage present in all decades of life in the trabecular meshwork, as detected by two-dimensional gel electrophoresis protein maps.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blotting, Western; Catalase; Child; Chondroitin S | 1996 |
Meningoencephalitis and brain abscessation due to Escherichia coli in a 2 week old alpaca cria.
Topics: Aging; Animals; Anorexia; Anti-Bacterial Agents; Anti-Inflammatory Agents; Brain; Brain Abscess; Cam | 1996 |
Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats.
Topics: Aging; Animals; Anti-Bacterial Agents; Blood Glucose; Blood Proteins; Body Weight; Creatinine; Eatin | 1997 |
Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise.
Topics: Aging; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Auditory Threshold; Cisplatin; Cochlea | 1997 |
Aminoglycosides activate oxygen metabolites production in the cochlea of mature and developing rats.
Topics: Aging; Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cochl | 1999 |
Comparison of methods for prediction of nephrotoxicity during development.
Topics: Aging; Amikacin; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Ge | 1992 |
Pharmacokinetics of gentamicin and antipyrine in the horse--effect of advancing age.
Topics: Aging; Animals; Antipyrine; Gentamicins; Horses | 1992 |
Variation in the pharmacokinetics of gentamicin and tobramycin in patients with pleural effusions and hypoalbuminemia.
Topics: Aged; Aging; Body Weight; Female; Fluorescence Polarization Immunoassay; Gentamicins; Half-Life; Hum | 1992 |
Accuracy of pharmacokinetic dose determination of gentamicin in geriatric patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Female; Gentamicins; Humans; Male; Middle Aged | 1990 |
Effect of age and renal function on gentamicin pharmacokinetic parameters.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Creatinine; Female; Gentamicins; Humans; Kidney D | 1989 |
Effect of age on the intracortical accumulation kinetics of gentamicin in rats.
Topics: Aging; Animals; Gentamicins; Glomerular Filtration Rate; Half-Life; Infusions, Intravenous; Kidney C | 1989 |
Disposition kinetics and urinary excretion of gentamicin in buffalo bulls (Bubalus bubalis).
Topics: Aging; Animals; Buffaloes; Gentamicins; Injections, Intramuscular; Male; Radioimmunoassay | 1989 |
The dissociation between aminoglycoside serum concentrations and nephrotoxicity.
Topics: Acetylglucosaminidase; Aging; Animals; Animals, Newborn; beta 2-Microglobulin; Creatinine; Gentamici | 1988 |
Population pharmacokinetics of gentamicin in neonates.
Topics: Aging; Apgar Score; Female; Gentamicins; Humans; Immunoenzyme Techniques; Infant, Newborn; Male | 1988 |
Alterations in aminoglycoside pharmacokinetics in patients with cancer.
Topics: Adolescent; Adult; Aging; Anti-Bacterial Agents; Child; Child, Preschool; Female; Gentamicins; Human | 1987 |
Determination of rat beta 2-microglobulin in urine and in serum. II. Application of its urinary measurement to selected nephrotoxicity models.
Topics: Acetylglucosaminidase; Aging; Albuminuria; Animals; beta 2-Microglobulin; Cadmium; Chromates; Female | 1986 |
Gentamicin disposition in young and elderly patients with various degrees of renal function.
Topics: Adult; Aged; Aged, 80 and over; Aging; Creatinine; Gentamicins; Half-Life; Humans; Kidney Diseases; | 1987 |
Autofluorescence and ageing: changes in ribosome accuracy and lysosome [corrected] function.
Topics: Aging; Anti-Bacterial Agents; Cell Line; Feedback; Fluorescence; Gentamicins; Humans; Lysosomes; Mit | 1986 |
Effect of gentamicin on isolated glomeruli and proximal tubules of the rabbit.
Topics: Aging; Animals; Creatinine; Female; Gentamicins; Glomerular Filtration Rate; Kidney Cortex; Kidney G | 1985 |
Postconceptional age and gentamicin elimination half-life.
Topics: Aging; Embryonic and Fetal Development; Gentamicins; Half-Life; Humans; Infant; Infant, Newborn; Inf | 1985 |
Pneumonia in the older patient.
Topics: Aged; Aging; Amantadine; Anti-Bacterial Agents; Cephalosporins; DNA Nucleotidyltransferases; Gentami | 1968 |