gentamicin has been researched along with Acute Liver Injury, Drug-Induced in 24 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The degree of hepatoprotection was measured by assessment of body weight, liver weight, absolute liver weight and estimations of plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct bilirubin, tissue malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activities." | 4.31 | Salicylic acid protects gentamicin-induced hepatotoxicity: Study in rabbits. ( Gulnaz, -; Sheikh Muhammad Usman, -; Syeda Nuzhat Fatima Zaidi, -, 2023) |
| " The results indicated that long-term VI-28 treatment invariably protected against oxidative tissue damage in the rat models of cerebral/myocardial ischemia-reperfusion injury, CCl4 hepatotoxicity, and gentamicin nephrotoxicity." | 3.74 | Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats. ( Chen, N; Chiu, PY; Ko, KM; Leung, HY; Poon, MK; Siu, AH, 2008) |
| " Similar findings were obtained in rats with CCl4 liver damage or gentamicin nephrotoxicity, except that those rats hardly exhibited anemia because of a simultaneous occurrence of hemoconcentration." | 3.67 | The influence of single or repeated phlebotomy on the physiological condition of normal and diseased rats. ( Furuhama, K; Igarashi, K; Kato, M; Onodera, T; Suzuki, N, 1987) |
| "Gentamicin (GM) is a commonly prescribed antimicrobial drug used for treatment of infections but associated hepatic and renal complications restrict its efficacy." | 1.62 | The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats. ( Abdeen, A; Abdelkader, A; Abdullah, O; Aboubaker, M; Alsanie, WF; Baioumy, B; Elkomy, A; Elnoury, HA; Gaber, A; Habotta, OA; Ibrahim, SF; Samir, A, 2021) |
| "Gentamicin (GM) is an aminoglycoside antibiotic that despite its antibacterial effects, its use is restricted due to numerous side effects." | 1.62 | Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats. ( Baharvand, F; Hosseini, A; Mirazi, N; Moghadasali, R; Nourian, A, 2021) |
| " The inability of BSS to protect against gentamicin nephrotoxicity was likely due to the relatively low bioavailability of BSS in rat kidneys." | 1.40 | β-sitosterol protects against carbon tetrachloride hepatotoxicity but not gentamicin nephrotoxicity in rats via the induction of mitochondrial glutathione redox cycling. ( Chan, WM; Chen, JH; Ko, KM; Leong, PK; Leung, HY; Wong, HS, 2014) |
| "The gentamicin was intraperitoneally injected to rats at dose level of 100 mg/kg b." | 1.40 | Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. ( Ahmed, OM; Galaly, SR; Mahmoud, AM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 6 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Laaroussi, H | 1 |
| Bakour, M | 1 |
| Ousaaid, D | 1 |
| Ferreira-Santos, P | 1 |
| Genisheva, Z | 1 |
| El Ghouizi, A | 1 |
| Aboulghazi, A | 1 |
| Teixeira, JA | 1 |
| Lyoussi, B | 1 |
| Abdeen, A | 1 |
| Samir, A | 1 |
| Elkomy, A | 1 |
| Aboubaker, M | 1 |
| Habotta, OA | 1 |
| Gaber, A | 1 |
| Alsanie, WF | 1 |
| Abdullah, O | 1 |
| Elnoury, HA | 1 |
| Baioumy, B | 1 |
| Ibrahim, SF | 1 |
| Abdelkader, A | 1 |
| Alam, W | 1 |
| Khan, H | 1 |
| Khan, SA | 1 |
| Ali, N | 1 |
| Sharif, N | 1 |
| Ghafar, R | 1 |
| Nazir, S | 1 |
| Daglia, M | 1 |
| Syeda Nuzhat Fatima Zaidi, - | 1 |
| Gulnaz, - | 1 |
| Sheikh Muhammad Usman, - | 1 |
| Ali, FEM | 1 |
| Hassanein, EHM | 1 |
| Bakr, AG | 1 |
| El-Shoura, EAM | 1 |
| El-Gamal, DA | 1 |
| Mahmoud, AR | 1 |
| Abd-Elhamid, TH | 1 |
| Mirazi, N | 1 |
| Baharvand, F | 1 |
| Moghadasali, R | 1 |
| Nourian, A | 1 |
| Hosseini, A | 1 |
| Hegazy, AM | 1 |
| Abdel-Azeem, AS | 1 |
| Zeidan, HM | 1 |
| Ibrahim, KS | 1 |
| Sayed, EE | 1 |
| Arjinajarn, P | 1 |
| Chueakula, N | 1 |
| Pongchaidecha, A | 1 |
| Jaikumkao, K | 1 |
| Chatsudthipong, V | 1 |
| Mahatheeranont, S | 1 |
| Norkaew, O | 1 |
| Chattipakorn, N | 1 |
| Lungkaphin, A | 1 |
| Xiao, Y | 1 |
| Zhou, K | 1 |
| Lu, Y | 1 |
| Yan, W | 1 |
| Cai, W | 1 |
| Wang, Y | 1 |
| Zhou, X | 1 |
| Ma, B | 1 |
| Lin, Z | 1 |
| Qu, Z | 1 |
| Huo, Y | 1 |
| Wang, J | 1 |
| Li, B | 1 |
| Wong, HS | 1 |
| Chen, JH | 1 |
| Leong, PK | 1 |
| Leung, HY | 2 |
| Chan, WM | 1 |
| Ko, KM | 2 |
| Galaly, SR | 1 |
| Ahmed, OM | 1 |
| Mahmoud, AM | 1 |
| Adeneye, AA | 1 |
| Benebo, AS | 1 |
| Li, YT | 1 |
| Wang, L | 1 |
| Chen, Y | 1 |
| Chen, YB | 1 |
| Wang, HY | 1 |
| Wu, ZW | 1 |
| Li, LJ | 1 |
| Zhou, Y | 1 |
| Vaidya, VS | 1 |
| Brown, RP | 1 |
| Zhang, J | 1 |
| Rosenzweig, BA | 1 |
| Thompson, KL | 1 |
| Miller, TJ | 1 |
| Bonventre, JV | 1 |
| Goering, PL | 1 |
| Chiu, PY | 1 |
| Siu, AH | 1 |
| Chen, N | 1 |
| Poon, MK | 1 |
| Whiting, PH | 2 |
| Thomson, AW | 2 |
| Simpson, JG | 2 |
| Davidson, RJ | 1 |
| Pollock, AA | 1 |
| Berger, SA | 1 |
| Simberkoff, MS | 1 |
| Rahal, JJ | 1 |
| Polunina, TE | 1 |
| Vasil'ev, AP | 1 |
| Fomichev, VI | 1 |
| de Lemos, E | 1 |
| Pariat, C | 1 |
| Piriou, A | 1 |
| Fauconneau, B | 1 |
| Courtois, P | 1 |
| Ohata, H | 1 |
| Hashimoto, T | 1 |
| Monose, K | 1 |
| Takahashi, A | 1 |
| Terao, T | 1 |
| Furuhama, K | 1 |
| Kato, M | 1 |
| Suzuki, N | 1 |
| Igarashi, K | 1 |
| Onodera, T | 1 |
| VanOmmen, RA | 1 |
24 other studies available for gentamicin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Protective Effect of Honey and Propolis against Gentamicin-Induced Oxidative Stress and Hepatorenal Damages.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gentamicins; Honey; Kidney; | 2021 |
The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; | 2021 |
Evaluation of hepatoprotective effects of crude methanolic extract of Datura metel L. in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Datura | 2021 |
Salicylic acid protects gentamicin-induced hepatotoxicity: Study in rabbits.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Body Weight; Ch | 2023 |
Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Chemical and Drug Induced | 2020 |
Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cytokines; | 2021 |
Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; D | 2018 |
Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats.
Topics: Animals; Anthocyanins; Apoptosis; Chemical and Drug Induced Liver Injury; Gentamicins; Inflammation; | 2017 |
Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling.
Topics: Animals; Bacterial Proteins; Bacteroides; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 2018 |
Evaluation of the usefulness of novel biomarkers for drug-induced acute kidney injury in beagle dogs.
Topics: Acute-Phase Proteins; Animals; Anti-Bacterial Agents; Biomarkers; Chemical and Drug Induced Liver In | 2014 |
β-sitosterol protects against carbon tetrachloride hepatotoxicity but not gentamicin nephrotoxicity in rats via the induction of mitochondrial glutathione redox cycling.
Topics: Animals; Antioxidants; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Live | 2014 |
Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Aspartate Aminotra | 2014 |
Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Dis | 2008 |
Effects of gut microflora on hepatic damage after acute liver injury in rats.
Topics: Animals; Bacterial Translocation; Chemical and Drug Induced Liver Injury; Cytokines; Endotoxins; Esc | 2010 |
Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.
Topics: Acetylglucosamine; Animals; Biomarkers; Cell Adhesion Molecules; Chemical and Drug Induced Liver Inj | 2008 |
Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats.
Topics: Animals; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury; Cholecalciferol; C | 2008 |
Renal and hepatic function in rats treated with cyclosporin A in combination with gentamicin or cephalosporin antibiotics.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Blood Proteins; Cephalosporins; Chemical and Dr | 1983 |
The toxic effects of combined administration of cyclosporin A and gentamicin.
Topics: Acetylglucosaminidase; Animals; Aspartate Aminotransferases; Blood Proteins; Bone Marrow; Chemical a | 1982 |
Hepatitis associated with high-dose oxacillin therapy.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Endocarditis, Bacterial; G | 1978 |
[A case of drug-induced hepatitis in a patient with chronic osteomyelitis].
Topics: Adult; Chemical and Drug Induced Liver Injury; Chronic Disease; Combined Modality Therapy; Drug Ther | 1992 |
[Circadian variations in the nephrotoxicity of the vancomycin-gentamicin combination in rats].
Topics: Acetylglucosaminidase; Aminopeptidases; Animals; CD13 Antigens; Chemical and Drug Induced Liver Inju | 1991 |
Urinalysis for detection of chemically induced renal damage (3)--Establishment and application of radioimmunoassay for lysozyme of rat urine.
Topics: Aminophenols; Animals; Chemical and Drug Induced Liver Injury; Gentamicins; Male; Mercuric Chloride; | 1988 |
The influence of single or repeated phlebotomy on the physiological condition of normal and diseased rats.
Topics: Anemia; Animals; Blood Cell Count; Blood Pressure; Bloodletting; Carbon Tetrachloride; Chemical and | 1987 |
Untoward effects of antimicrobial agents on major organ systems.
Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia; | 1974 |