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gentamicin and Acute Liver Injury, Drug-Induced

gentamicin has been researched along with Acute Liver Injury, Drug-Induced in 24 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

ExcerptRelevanceReference
" The degree of hepatoprotection was measured by assessment of body weight, liver weight, absolute liver weight and estimations of plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct bilirubin, tissue malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activities."4.31Salicylic acid protects gentamicin-induced hepatotoxicity: Study in rabbits. ( Gulnaz, -; Sheikh Muhammad Usman, -; Syeda Nuzhat Fatima Zaidi, -, 2023)
" The results indicated that long-term VI-28 treatment invariably protected against oxidative tissue damage in the rat models of cerebral/myocardial ischemia-reperfusion injury, CCl4 hepatotoxicity, and gentamicin nephrotoxicity."3.74Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats. ( Chen, N; Chiu, PY; Ko, KM; Leung, HY; Poon, MK; Siu, AH, 2008)
" Similar findings were obtained in rats with CCl4 liver damage or gentamicin nephrotoxicity, except that those rats hardly exhibited anemia because of a simultaneous occurrence of hemoconcentration."3.67The influence of single or repeated phlebotomy on the physiological condition of normal and diseased rats. ( Furuhama, K; Igarashi, K; Kato, M; Onodera, T; Suzuki, N, 1987)
"Gentamicin (GM) is a commonly prescribed antimicrobial drug used for treatment of infections but associated hepatic and renal complications restrict its efficacy."1.62The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats. ( Abdeen, A; Abdelkader, A; Abdullah, O; Aboubaker, M; Alsanie, WF; Baioumy, B; Elkomy, A; Elnoury, HA; Gaber, A; Habotta, OA; Ibrahim, SF; Samir, A, 2021)
"Gentamicin (GM) is an aminoglycoside antibiotic that despite its antibacterial effects, its use is restricted due to numerous side effects."1.62Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats. ( Baharvand, F; Hosseini, A; Mirazi, N; Moghadasali, R; Nourian, A, 2021)
" The inability of BSS to protect against gentamicin nephrotoxicity was likely due to the relatively low bioavailability of BSS in rat kidneys."1.40β-sitosterol protects against carbon tetrachloride hepatotoxicity but not gentamicin nephrotoxicity in rats via the induction of mitochondrial glutathione redox cycling. ( Chan, WM; Chen, JH; Ko, KM; Leong, PK; Leung, HY; Wong, HS, 2014)
"The gentamicin was intraperitoneally injected to rats at dose level of 100 mg/kg b."1.40Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. ( Ahmed, OM; Galaly, SR; Mahmoud, AM, 2014)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19906 (25.00)18.7374
1990's2 (8.33)18.2507
2000's3 (12.50)29.6817
2010's7 (29.17)24.3611
2020's6 (25.00)2.80

Authors

AuthorsStudies
Laaroussi, H1
Bakour, M1
Ousaaid, D1
Ferreira-Santos, P1
Genisheva, Z1
El Ghouizi, A1
Aboulghazi, A1
Teixeira, JA1
Lyoussi, B1
Abdeen, A1
Samir, A1
Elkomy, A1
Aboubaker, M1
Habotta, OA1
Gaber, A1
Alsanie, WF1
Abdullah, O1
Elnoury, HA1
Baioumy, B1
Ibrahim, SF1
Abdelkader, A1
Alam, W1
Khan, H1
Khan, SA1
Ali, N1
Sharif, N1
Ghafar, R1
Nazir, S1
Daglia, M1
Syeda Nuzhat Fatima Zaidi, -1
Gulnaz, -1
Sheikh Muhammad Usman, -1
Ali, FEM1
Hassanein, EHM1
Bakr, AG1
El-Shoura, EAM1
El-Gamal, DA1
Mahmoud, AR1
Abd-Elhamid, TH1
Mirazi, N1
Baharvand, F1
Moghadasali, R1
Nourian, A1
Hosseini, A1
Hegazy, AM1
Abdel-Azeem, AS1
Zeidan, HM1
Ibrahim, KS1
Sayed, EE1
Arjinajarn, P1
Chueakula, N1
Pongchaidecha, A1
Jaikumkao, K1
Chatsudthipong, V1
Mahatheeranont, S1
Norkaew, O1
Chattipakorn, N1
Lungkaphin, A1
Xiao, Y1
Zhou, K1
Lu, Y1
Yan, W1
Cai, W1
Wang, Y1
Zhou, X1
Ma, B1
Lin, Z1
Qu, Z1
Huo, Y1
Wang, J1
Li, B1
Wong, HS1
Chen, JH1
Leong, PK1
Leung, HY2
Chan, WM1
Ko, KM2
Galaly, SR1
Ahmed, OM1
Mahmoud, AM1
Adeneye, AA1
Benebo, AS1
Li, YT1
Wang, L1
Chen, Y1
Chen, YB1
Wang, HY1
Wu, ZW1
Li, LJ1
Zhou, Y1
Vaidya, VS1
Brown, RP1
Zhang, J1
Rosenzweig, BA1
Thompson, KL1
Miller, TJ1
Bonventre, JV1
Goering, PL1
Chiu, PY1
Siu, AH1
Chen, N1
Poon, MK1
Whiting, PH2
Thomson, AW2
Simpson, JG2
Davidson, RJ1
Pollock, AA1
Berger, SA1
Simberkoff, MS1
Rahal, JJ1
Polunina, TE1
Vasil'ev, AP1
Fomichev, VI1
de Lemos, E1
Pariat, C1
Piriou, A1
Fauconneau, B1
Courtois, P1
Ohata, H1
Hashimoto, T1
Monose, K1
Takahashi, A1
Terao, T1
Furuhama, K1
Kato, M1
Suzuki, N1
Igarashi, K1
Onodera, T1
VanOmmen, RA1

Other Studies

24 other studies available for gentamicin and Acute Liver Injury, Drug-Induced

ArticleYear
Protective Effect of Honey and Propolis against Gentamicin-Induced Oxidative Stress and Hepatorenal Damages.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gentamicins; Honey; Kidney;

2021
The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 143

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury;

2021
Evaluation of hepatoprotective effects of crude methanolic extract of Datura metel L. in mice.
    Cellular and molecular biology (Noisy-le-Grand, France), 2021, Jan-31, Volume: 67, Issue:1

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Datura

2021
Salicylic acid protects gentamicin-induced hepatotoxicity: Study in rabbits.
    Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:3

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Body Weight; Ch

2023
Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways.
    Life sciences, 2020, Aug-01, Volume: 254

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Chemical and Drug Induced

2020
Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cytokines;

2021
Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats.
    Human & experimental toxicology, 2018, Volume: 37, Issue:4

    Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; D

2018
Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 92

    Topics: Animals; Anthocyanins; Apoptosis; Chemical and Drug Induced Liver Injury; Gentamicins; Inflammation;

2017
Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling.
    Experimental & molecular medicine, 2018, 11-30, Volume: 50, Issue:12

    Topics: Animals; Bacterial Proteins; Bacteroides; Chemical and Drug Induced Liver Injury; Child; Child, Pres

2018
Evaluation of the usefulness of novel biomarkers for drug-induced acute kidney injury in beagle dogs.
    Toxicology and applied pharmacology, 2014, Oct-01, Volume: 280, Issue:1

    Topics: Acute-Phase Proteins; Animals; Anti-Bacterial Agents; Biomarkers; Chemical and Drug Induced Liver In

2014
β-sitosterol protects against carbon tetrachloride hepatotoxicity but not gentamicin nephrotoxicity in rats via the induction of mitochondrial glutathione redox cycling.
    Molecules (Basel, Switzerland), 2014, Oct-30, Volume: 19, Issue:11

    Topics: Animals; Antioxidants; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Live

2014
Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2014, Volume: 65, Issue:6

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Aspartate Aminotra

2014
Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats.
    Journal of ethnopharmacology, 2008, Jul-23, Volume: 118, Issue:2

    Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Dis

2008
Effects of gut microflora on hepatic damage after acute liver injury in rats.
    The Journal of trauma, 2010, Volume: 68, Issue:1

    Topics: Animals; Bacterial Translocation; Chemical and Drug Induced Liver Injury; Cytokines; Endotoxins; Esc

2010
Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 101, Issue:1

    Topics: Acetylglucosamine; Animals; Biomarkers; Cell Adhesion Molecules; Chemical and Drug Induced Liver Inj

2008
Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats.
    Rejuvenation research, 2008, Volume: 11, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury; Cholecalciferol; C

2008
Renal and hepatic function in rats treated with cyclosporin A in combination with gentamicin or cephalosporin antibiotics.
    British journal of experimental pathology, 1983, Volume: 64, Issue:6

    Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Blood Proteins; Cephalosporins; Chemical and Dr

1983
The toxic effects of combined administration of cyclosporin A and gentamicin.
    British journal of experimental pathology, 1982, Volume: 63, Issue:5

    Topics: Acetylglucosaminidase; Animals; Aspartate Aminotransferases; Blood Proteins; Bone Marrow; Chemical a

1982
Hepatitis associated with high-dose oxacillin therapy.
    Archives of internal medicine, 1978, Volume: 138, Issue:6

    Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Endocarditis, Bacterial; G

1978
[A case of drug-induced hepatitis in a patient with chronic osteomyelitis].
    Terapevticheskii arkhiv, 1992, Volume: 64, Issue:10

    Topics: Adult; Chemical and Drug Induced Liver Injury; Chronic Disease; Combined Modality Therapy; Drug Ther

1992
[Circadian variations in the nephrotoxicity of the vancomycin-gentamicin combination in rats].
    Pathologie-biologie, 1991, Volume: 39, Issue:1

    Topics: Acetylglucosaminidase; Aminopeptidases; Animals; CD13 Antigens; Chemical and Drug Induced Liver Inju

1991
Urinalysis for detection of chemically induced renal damage (3)--Establishment and application of radioimmunoassay for lysozyme of rat urine.
    Archives of toxicology, 1988, Volume: 62, Issue:1

    Topics: Aminophenols; Animals; Chemical and Drug Induced Liver Injury; Gentamicins; Male; Mercuric Chloride;

1988
The influence of single or repeated phlebotomy on the physiological condition of normal and diseased rats.
    The Journal of toxicological sciences, 1987, Volume: 12, Issue:1

    Topics: Anemia; Animals; Blood Cell Count; Blood Pressure; Bloodletting; Carbon Tetrachloride; Chemical and

1987
Untoward effects of antimicrobial agents on major organ systems.
    The Medical clinics of North America, 1974, Volume: 58, Issue:3

    Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia;

1974