Page last updated: 2024-10-27

gentamicin and Acute Kidney Tubular Necrosis

gentamicin has been researched along with Acute Kidney Tubular Necrosis in 78 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in gentamicin-induced acute tubular necrosis in rats using the iNOS inhibitor L-N6-(1-iminoethyl) lysine (L-NIL)."7.74The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović-Dzuvo, A; Nakas-Ićindić, E; Rasić, S; Valjevac, A; Zaciragić, A, 2007)
"The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in gentamicin-induced acute tubular necrosis in rats using the iNOS inhibitor L-N6-(1-iminoethyl) lysine (L-NIL)."3.74The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović-Dzuvo, A; Nakas-Ićindić, E; Rasić, S; Valjevac, A; Zaciragić, A, 2007)
" Six patients had acute tubular necrosis, due to rhabdomyolysis in 5 and to prolonged gentamicin therapy for bacterial endocarditis in 1."3.67[Renal disease associated with heroin abuse]. ( Beaufils, H; Chauveau, P; Mougenot, B; Pourriat, JL; Rondeau, E; Uzan, M; Viron, B; Volochine, L, 1988)
" coli-pyelonephritis facilitated by oestradiolundecylate, aminonucleoside nephrosis, aminoglycoside induced renal lesions and pyelonephritic animals treated with therapeutic and toxic doses of tobramycin."3.65The diagnostic value of enzymuria, cell excretion, and proteinuria in experimental renal diseases. ( Sack, K; Wilhelm, J, 1975)
" To show clinical relevance, we use quantitative systems pharmacology computational models for in vitro-in vivo translation of the experimental results and to identify favorable dosing regimens for one of the tested drugs."1.51Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System. ( Cirit, M; Himmelfarb, J; Kelly, EJ; Maass, C; Sorensen, NB; Stokes, CL, 2019)
"Dipyridamole pretreatment in gentamicin-administered rats afforded a noticeable renoprotection by markedly preventing renal structural and functional abnormalities, renal inflammation and serum uric acid elevation."1.46Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat. ( Bahari, MB; Balakumar, P; Gan, YS; Jayachristy, SA; JemayPuah, SM; Kuganesswari, S; Prajapati, SK; Sundram, K; Varatharajan, R; WitnessKoe, WE, 2017)
" Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage."1.42Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase. ( Blanco-Gozalo, V; García-Sánchez, O; González-Buitrago, JM; López-Hernández, FJ; López-Novoa, JM; Morales, AI; Pescador, M; Sánchez-Juanes, F; Sevilla, MA; Vicente-Vicente, L, 2015)
"Hydrogen sulfide (H2S) is a signaling molecule involved in inflammation."1.38Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin. ( Chierice, JR; Coimbra, TM; Costa, RS; Cunha, FQ; Francescato, HD; Marin, EC; Silva, CG, 2012)
"Rosmarinic acid (RA) has been demonstrated to have antioxidant, free radical scavenger and anti-inflammatory effects."1.37Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats. ( Ahmadvand, H; Tavafi, M, 2011)
" Our results indicated that CAPE acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GEN both at the biochemical and histological level."1.33Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. ( Acet, A; Bay-Karabulut, A; Parlakpinar, H; Polat, A; Tasdemir, S; Ucar, M; Vardi, N, 2005)
"and gentamicin group was injected with gentamicin in the dose of 80 mg/kg/day i."1.33Nitric oxide in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović, A; Mijanović, M; Nakas-Ićindić, E; Prasović, S; Tahirović, G; Zaciragić, A, 2005)
"Gentamicin-treated rats presented a transitory increase in plasma creatinine levels."1.33Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. ( Balbi, AP; Coimbra, TM; Costa, RS; Volpini, RA, 2006)
"Taurine treatment reduced gentamicin-induced increases in serum creatinine, 24 h urine volume, BUN and tissue lactate and TBARS levels (0."1.31The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. ( Bozkurt, A; Erdem, A; Erdem, SR; Gündoğan, NU; Kara, A; Kilinç, K; Usubütün, A, 2000)
"Sonography was performed before and during the onset and progression of nephrotoxicosis induced by administration of a toxic dosage of gentamicin."1.29Gray-scale sonographic characterization of aminoglycoside-induced nephrotoxicosis in a canine model. ( Finlay, DE; Holm, JC; King, VL; Letourneau, JG; O'Brien, TD; Polzin, DJ; Ritenour, ER; Rivers, BJ; Walter, PA, 1996)
"Gentamicin can cause proximal tubule necrosis."1.28Calcium supplementation and thyroid hormone protect against gentamicin-induced inhibition of proximal tubular Na+,K(+)-ATPase activity and other renal functional changes. ( Aperia, A; Eklöf, AC; Fukuda, Y; Malmborg, AS, 1992)
"Gentamicin was injected subcutaneously at 40 mg/kg body weight."1.28An electron microscopy study of urinary sediment: relationship between myeloid body excretion and gentamicin nephrotoxicity in the rat. ( Bell, RD; Caruso, DE; Hillman, NM; Mandal, AK; Saklayen, MG; Taylor, CA, 1991)
"Gentamicin-treated rats showed marked elevation of blood urea nitrogen, extensive tubular necrosis in the kidney and haemosiderin deposition in the spleen."1.28Effect of recombinant human erythropoietin on new anaemic model rats induced by gentamicin. ( Arai, H; Koumegawa, J; Kusaka, M; Nagano, N; Wada, M, 1990)
" These findings suggest that some aspects of the functional or metabolic heterogeneity within the PCT may be related to either differential rates of uptake of the drug or to differences in intrinsic susceptibility to its toxic effects."1.28Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule. ( Burke, TJ; Shanley, PF, 1990)
" Bile duct ligated and gentamicin injected rats elicited a decline in renal function and tubular cell necrosis after 8 days of treatment whereas equal dosage regimen in sham operated rats exhibited no evidence of renal dysfunction."1.28Enhanced gentamicin nephrotoxicity after experimental biliary obstruction in rats. ( Andrade, RJ; Gonzalez-Correa, JA; Ibañez, J; Lucena, MI; Sanchez de la Cuesta, F; Torres, D, 1989)
" We concluded that hydrocortisone interferes with the postnecrotic cellular regeneration process, an important step that is responsible for the recovery of normal kidney structure following toxic injuries associated with aminoglycoside therapy."1.27Influence of hydrocortisone on gentamicin-induced nephrotoxicity in rats. ( Beauchamp, D; Pettigrew, M, 1988)
"The etiology of acute renal failure has changed in recent years due to the recognition of drug nephrotoxicity as a more common cause."1.26Pathogenesis of renal failure due to aminoglycosides and contrast media used in roentgenography. ( Bennett, WM; Luft, F; Porter, GA, 1980)
" An identical dosage of tobramycin was associated with only minimal morphological changes and normal concentrations of serum creatinine and blood urea nitrogen."1.26Comparative nephrotoxicity of gentamicin and tobramycin in rats. ( Bennet, WM; Gilbert, DN; Houghton, DC; Plamp, C; Porter, G; Starr, P, 1978)
"Rats recovering from HgCl2-induced acute renal failure were resistant to a depression in glomerular filtration when given gentamicin."1.26The effect of concomitant mercuric chloride and gentamicin on kidney function and structure in the rat. ( Kleit, SA; Luft, FC; Yum, MN, 1977)
" The morphologically immature regenerating cells are apparently metabolically immature as well and appear not to be susceptible to toxic effects of the drug."1.26A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. ( Bennett, W; Campbell-Boswell, M; Hartnett, M; Houghton, DC; Porter, G, 1976)

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199032 (41.03)18.7374
1990's23 (29.49)18.2507
2000's14 (17.95)29.6817
2010's9 (11.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maass, C1
Sorensen, NB1
Himmelfarb, J1
Kelly, EJ1
Stokes, CL1
Cirit, M1
Vicente-Vicente, L1
Sánchez-Juanes, F1
García-Sánchez, O1
Blanco-Gozalo, V1
Pescador, M1
Sevilla, MA1
González-Buitrago, JM1
López-Hernández, FJ1
López-Novoa, JM1
Morales, AI1
Biro, A1
Vaknine, H1
Cohen-Armon, M1
Matas, Z1
Fux, A1
Schreiber, L1
Berger, E1
Dan, M1
Boaz, M1
Gregoriev, O1
Katzir, Z1
Balakumar, P1
WitnessKoe, WE1
Gan, YS1
JemayPuah, SM1
Kuganesswari, S1
Prajapati, SK1
Varatharajan, R1
Jayachristy, SA1
Sundram, K1
Bahari, MB1
Romero, F1
Pérez, M1
Chávez, M1
Parra, G1
Durante, P1
Ozbek, E1
Cekmen, M1
Ilbey, YO1
Simsek, A1
Polat, EC1
Somay, A1
Cao, J1
Yang, XD1
Wang, XY1
Qu, L1
Liu, G1
Li, XM1
Tavafi, M1
Ahmadvand, H1
Aksoy, N1
Dogan, Y1
Iriadam, M1
Bitiren, M1
Uzer, E1
Ozgonul, A1
Aksoy, S1
Francescato, HD1
Chierice, JR1
Marin, EC1
Cunha, FQ1
Costa, RS2
Silva, CG1
Coimbra, TM2
Liu, L1
Chen, D1
Yi, ZW1
Liu, XH1
Wu, XC1
Dang, XQ1
He, QN1
He, XJ1
Mo, SH1
Cunha, MA1
Schor, N1
Fogo, AB1
Kopple, JD1
Ding, H1
Letoha, A1
Ivanyi, B1
Qing, DP1
Dux, L1
Wang, HY1
Sonkodi, S1
Ziai, SA1
Salehian, P1
Mahmoudian, M1
Parlakpinar, H1
Tasdemir, S1
Polat, A1
Bay-Karabulut, A1
Vardi, N1
Ucar, M1
Acet, A1
Nakas-Ićindić, E2
Avdagić, N2
Mijanović, M1
Prasović, S1
Zaciragić, A2
Hadzović, A1
Tahirović, G1
Volpini, RA1
Balbi, AP1
Rasić, S1
Hadzović-Dzuvo, A1
Valjevac, A1
Furuhama, K1
Onodera, T1
Jao, W1
Manaligod, JR1
Gerardo, LT1
Castillo, MM1
Feinfeld, DA1
Sherman, RA1
Safirstein, R1
Ohmi, N1
Fuh, VL1
Arias, IM1
Levine, SD1
Kojima, R2
Suzuki, Y2
Sugarman, A1
Brown, RS1
Silva, P1
Rosen, S1
Hirokawa, N1
Naruse, T1
Weinberg, EH1
Field, WE1
Gray, WD1
Klein, MF1
Robbins, GR1
Schwartz, E1
Belizon, IJ1
Chou, S1
Porush, JG1
Gomez-Leon, G1
Shapiro, WB1
Bennett, WM4
Luft, F1
Porter, GA3
Reimschuessel, R1
Williams, D1
Kishore, BK1
Van Schepdael, A1
Laurent, G4
Lambricht, P1
Claes, PJ1
Piret, J1
Tulkens, PM2
Maldague, P2
Du, XH2
Yang, CL2
Weir, BA1
Mazumdar, DC1
Nonclercq, D2
Wrona, S2
Toubeau, G2
Zanen, J2
Heuson-Stiennon, JA2
Schaudies, RP2
Komatsuda, A1
Wakui, H1
Satoh, K1
Yasuda, T1
Imai, H1
Nakamoto, Y1
Miura, AB1
Itoh, H1
Tashima, Y1
Rivers, BJ1
Walter, PA1
Holm, JC1
Letourneau, JG1
Finlay, DE1
Ritenour, ER1
King, VL1
O'Brien, TD1
Polzin, DJ1
Hayashi, M1
Numaguchi, M1
Watabe, H1
Enomoto, H1
Yaoi, Y1
Erdem, A1
Gündoğan, NU1
Usubütün, A1
Kilinç, K1
Erdem, SR1
Kara, A1
Bozkurt, A1
Xie, Y1
Nishi, S1
Iguchi, S1
Imai, N1
Sakatsume, M1
Saito, A1
Ikegame, M1
Iino, N1
Shimada, H1
Ueno, M1
Kawashima, H1
Arakawa, M1
Gejyo, F1
Kalaidjieva, VC1
Iliev, ZK1
Yu, Y1
Zheng, F1
Bo, Y1
Duan, J1
Huang, H1
Yazaki, T1
Yoshiyama, Y1
Wong, P1
Beauchamp, D3
Kanke, M1
Plamp, CE2
Parker, RA1
Gilbert, DN4
Houghton, DC4
Clark, CH1
Reger, K1
Plamp, C1
Starr, P1
Bennet, WM1
Porter, G2
Luft, FC3
Yum, MN3
Kleit, SA3
Walker, PD1
Hautmann, R1
Kurth, M1
Buss, H1
Lutzeyer, W1
Valtonen, VV1
Pentikäinen, PJ1
Wellwood, JM1
Thompson, AE1
Tighe, JR1
Cabanillas, F1
Burgos, RC1
Rodríguez, C1
Baldizón, C1
Sack, K1
Wilhelm, J1
Leisinger, HJ1
Hartnett, M1
Campbell-Boswell, M1
Bennett, W1
Fukuda, Y1
Eklöf, AC1
Malmborg, AS1
Aperia, A1
Ali, BH1
Abdel Gayoum, AA1
Bashir, AA1
Chmielnicka, J1
Szymańska, JA1
Brzeźnicka, EA1
Kałuzyński, A1
Enriquez, JI1
Schydlower, M1
O'Hair, KC1
Keniston, RC1
Nadjem, MA1
Delgado, I1
Zou, WZ1
Chen, W1
Thomsen, HS1
Golman, K1
Larsen, S1
Hemmingsen, L1
Skaarup, P1
Mandal, AK1
Saklayen, MG1
Taylor, CA1
Caruso, DE1
Hillman, NM1
Bell, RD1
Swan, SK1
Kohlhepp, SJ1
Kohnen, PW1
Nagano, N1
Koumegawa, J1
Arai, H1
Wada, M1
Kusaka, M1
Hackett, RL1
Shevock, PN1
Khan, SR1
Shanley, PF1
Burke, TJ1
Wu, DF1
Griffith, OW1
Reidenberg, MM1
Garry, F1
Chew, DJ1
Hoffsis, GF1
Lucena, MI1
Gonzalez-Correa, JA1
Andrade, RJ1
Ibañez, J1
Torres, D1
Sanchez de la Cuesta, F2
Gomez, A1
Martos, F1
Garcia, R1
Perez, B1
Pettigrew, M1
Jelkmann, W1
Marienhoff, N1
Giesselmann, S1
Busch, L1
Uzan, M1
Volochine, L1
Rondeau, E1
Viron, B1
Mougenot, B1
Beaufils, H1
Pourriat, JL1
Chauveau, P1
Aynedjian, HS1
Nguyen, D1
Lee, HY1
Sablay, LB1
Bank, N1
Matsuda, O1
Beck, FX1
Dörge, A1
Thurau, K1

Reviews

1 review available for gentamicin and Acute Kidney Tubular Necrosis

ArticleYear
Toxicity of aminoglycoside antibiotics.
    Modern veterinary practice, 1977, Volume: 58, Issue:7

    Topics: Aminoglycosides; Animals; Ataxia; Cat Diseases; Cats; Deafness; Dog Diseases; Dogs; Gentamicins; Hea

1977

Trials

1 trial available for gentamicin and Acute Kidney Tubular Necrosis

ArticleYear
Cisplatin-induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels.
    Acta obstetricia et gynecologica Scandinavica, 1997, Volume: 76, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cross-Over Studies; Female; Fosfom

1997

Other Studies

76 other studies available for gentamicin and Acute Kidney Tubular Necrosis

ArticleYear
Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System.
    CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:5

    Topics: Biomarkers; Cell Line; Cisplatin; Gentamicins; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney

2019
Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.
    Toxicology letters, 2015, Apr-16, Volume: 234, Issue:2

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Biomarkers; Cisplatin; Disease Models, Animal;

2015
The effect of poly (ADP-ribose) polymerase inhibition on aminoglycoside-induced acute tubular necrosis in rats.
    Clinical nephrology, 2016, Volume: 85, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Benzamides; Creatinine; Dilatation, Pathologic; Drug Interactions; E

2016
Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat.
    Regulatory toxicology and pharmacology : RTP, 2017, Volume: 84

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Creatinine; Cytoprotection; Dipyridamole; Disease Mod

2017
Effect of uric acid on gentamicin-induced nephrotoxicity in rats - role of matrix metalloproteinases 2 and 9.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Gentamicins; Kidney; Kidney Function Tests; Kidney Tubular Necrosis,

2009
Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways.
    Renal failure, 2009, Volume: 31, Issue:5

    Topics: Analysis of Variance; Animals; Atorvastatin; Chi-Square Distribution; Disease Models, Animal; Free R

2009
[Differential changes of intrarenal oxygenation in rat models of acute tubular necrosis caused by aristolochic acid and gentamicin].
    Zhonghua yi xue za zhi, 2010, May-04, Volume: 90, Issue:17

    Topics: Animals; Aristolochic Acids; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Male; Rats; Rats,

2010
Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats.
    Tissue & cell, 2011, Volume: 43, Issue:6

    Topics: Animals; Antioxidants; Biomarkers; Cinnamates; Creatinine; Depsides; Gentamicins; Glutathione; Kidne

2011
Protective and therapeutic effects of licorice in rats with acute tubular necrosis.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2012, Volume: 22, Issue:3

    Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Gentamicins; Glutathione; Glycyrrhiza; Kidne

2012
Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2012, Volume: 45, Issue:3

    Topics: Alkynes; Animals; Anti-Bacterial Agents; Creatinine; Gentamicins; Glycine; Hydrogen Sulfide; Immunoh

2012
Nephroprotective effects of subcapsular transplantation of metanephric mesenchymal cells on gentamicin-induced acute tubular necrosis in rats.
    World journal of pediatrics : WJP, 2012, Volume: 8, Issue:2

    Topics: Animals; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Mesenchymal Stem Cell Transpla

2012
Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells.
    Renal failure, 2002, Volume: 24, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calcium; Contrast Media; Disease Models, Animal; Gentamic

2002
Quiz page. Mesangial lupus nephritis, WHO IIb, and severe acute tubular necrosis, secondary to gentamycin toxicity.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 40, Issue:5

    Topics: Adult; Diabetes Mellitus; Diagnosis, Differential; Female; Fever; Gentamicins; Glomerular Mesangium;

2002
L-carnitine ameliorates gentamicin-induced renal injury in rats.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:12

    Topics: Animals; Carnitine; Dose-Response Relationship, Drug; Drug Administration Schedule; Gentamicins; Inj

2002
Study of serum and tissues angiotensin converting enzyme (ACE) activity in rat with gentamicin induced renal toxicity.
    Renal failure, 2003, Volume: 25, Issue:6

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Chromatography, High

2003
Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats.
    Toxicology, 2005, Feb-14, Volume: 207, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Caffeic Acids; Catalase; Female; Free Radical S

2005
Nitric oxide in gentamicin-induced acute tubular necrosis in rats.
    Bosnian journal of basic medical sciences, 2005, Volume: 5, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Biomarkers; Colorimetry; Disease Models, Animal; Female; Gentamicins

2005
Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2006, Volume: 39, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Creatinine; Female; Fibrosis; Gentamicins; Immuno

2006
The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats.
    Bosnian journal of basic medical sciences, 2007, Volume: 7, Issue:4

    Topics: Animals; Enzyme Inhibitors; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Lysine; Mal

2007
[Studies on experimental renal damage in rats. II. beta 2-microglobulin: purification, radioimmunoassay, and urine and serum levels in tubular nephropathy].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:5

    Topics: Acute Kidney Injury; Animals; beta 2-Microglobulin; Beta-Globulins; Cephaloridine; Female; Gentamici

1982
Myeloid bodies in drug-induced acute tubular necrosis.
    The Journal of pathology, 1983, Volume: 139, Issue:1

    Topics: Acute Kidney Injury; Adult; Chromium; Epithelium; Female; Gentamicins; Humans; Inclusion Bodies; Kid

1983
Urinary ligandin in renal tubular cell injury.
    Contributions to nephrology, 1984, Volume: 42

    Topics: Animals; Cisplatin; Contrast Media; Gentamicins; Glutathione Transferase; Humans; Kidney; Kidney Tra

1984
[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (1). Nephrotoxicity of gentamicin and mercuric chloride].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984, Volume: 84, Issue:5

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Enzymes; Gentamicins; Kidney; Kidney Tubular Necr

1984
[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (2). Protective effect of latamoxef against gentamicin nephrotoxicity].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984, Volume: 84, Issue:5

    Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Gen

1984
Features of gentamicin nephrotoxicity and effect of concurrent cephalothin in the rat.
    Nephron, 1983, Volume: 34, Issue:4

    Topics: Acute Kidney Injury; Animals; Cephalothin; Gentamicins; Glomerular Filtration Rate; Kidney; Kidney C

1983
[Clinical evaluation of urinary n-acetyl-beta-d-glucosaminidase activity in patients treated with aminoglycosides].
    Nihon Jinzo Gakkai shi, 1982, Volume: 24, Issue:9

    Topics: Acetylglucosaminidase; Acute Kidney Injury; Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial

1982
Preclinical toxicologic studies of netilmicin.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Dogs; Dose-Response Relationship, Drug; Fema

1981
Recovery without a diuresis after protracted acute tubular necrosis.
    Archives of internal medicine, 1980, Volume: 140, Issue:1

    Topics: Acute Kidney Injury; Cephalosporins; Cephapirin; Diuresis; Female; Gentamicins; Humans; Kidney Tubul

1980
Pathogenesis of renal failure due to aminoglycosides and contrast media used in roentgenography.
    The American journal of medicine, 1980, Volume: 69, Issue:5

    Topics: Acute Kidney Injury; Aminoglycosides; Animals; Contrast Media; Dogs; Gentamicins; Humans; Kidney Tub

1980
Development of new nephrons in adult kidneys following gentamicin-induced nephrotoxicity.
    Renal failure, 1995, Volume: 17, Issue:2

    Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Gentamicins; Goldfish; Immunoh

1995
Co-oxydextran as a protectant against gentamicin-induced renal lysosomal phospholipidosis and focal tubular necrosis. Perspectives and limitations.
    Contributions to nephrology, 1993, Volume: 101

    Topics: Animals; Anions; Cell Division; Dextrans; Female; Gentamicins; Kidney Diseases; Kidney Tubular Necro

1993
Mechanism of gentamicin nephrotoxicity in rats and the protective effect of zinc-induced metallothionein synthesis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9 Suppl 4

    Topics: Acute Kidney Injury; Animals; DNA; Free Radicals; Gentamicins; Hydroxyl Radical; In Vitro Techniques

1994
Aminoglycoside nephrotoxicity following single-dose cystoscopy prophylaxis.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:2

    Topics: Aged; Aged, 80 and over; Cystoscopy; Gentamicins; Humans; Kidney Tubular Necrosis, Acute; Male; Prem

1994
Immunohistochemical study of epidermal growth factor in the rat kidney after gentamicin-induced tubular injury.
    Contributions to nephrology, 1993, Volume: 101

    Topics: Animals; Epidermal Growth Factor; Female; Gentamicins; Immunohistochemistry; Kidney Tubular Necrosis

1993
Altered localization of 73-kilodalton heat-shock protein in rat kidneys with gentamicin-induced acute tubular injury.
    Laboratory investigation; a journal of technical methods and pathology, 1993, Volume: 68, Issue:6

    Topics: Animals; Disease Models, Animal; Gentamicins; Heat-Shock Proteins; Kidney Tubular Necrosis, Acute; L

1993
Gray-scale sonographic characterization of aminoglycoside-induced nephrotoxicosis in a canine model.
    Investigative radiology, 1996, Volume: 31, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Biopsy; Dogs; Female; Gentamicins; Image Processing, Computer-Assist

1996
The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:8

    Topics: Acute Disease; Animals; Creatinine; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Lac

2000
Expression of osteopontin in gentamicin-induced acute tubular necrosis and its recovery process.
    Kidney international, 2001, Volume: 59, Issue:3

    Topics: Animals; Biomarkers; Gentamicins; Hyaluronan Receptors; Kidney; Kidney Tubular Necrosis, Acute; Male

2001
Plasma erythropoietin level in rats after kidney proximal tubular impairment.
    Folia medica, 2000, Volume: 42, Issue:3

    Topics: Anemia; Animals; Disease Models, Animal; Erythropoiesis; Erythropoietin; Gentamicins; Hematologic Te

2000
[Changes of prostaglandins in kidney tissue in gentamicin-induced acute renal tubular injury in rats].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1998, Volume: 20, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Epidermal Growth Factor; Female; Gentamicins; K

1998
Protective effect of fleroxacin against the nephrotoxicity of isepamicin in rats.
    Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:4

    Topics: Acetylglucosaminidase; Animals; Blood Urea Nitrogen; Creatinine; Drug Therapy, Combination; Fleroxac

2002
Renal transport of organic acids and bases in aminoglycoside nephrotoxicity.
    Antimicrobial agents and chemotherapy, 1979, Volume: 16, Issue:2

    Topics: Acute Kidney Injury; Aminoglycosides; Animals; Biological Transport; Gentamicins; Kidney; Kidney Fun

1979
Reversibility of gentamicin nephrotoxicity in rats: recovery during continuous drug administration.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 160, Issue:1

    Topics: Acute Kidney Injury; Animals; Creatinine; Gentamicins; Kidney Concentrating Ability; Kidney Tubular

1979
Comparative nephrotoxicity of gentamicin and tobramycin in rats.
    Antimicrobial agents and chemotherapy, 1978, Volume: 13, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Kidney; Kidney Tubular Necrosis

1978
The effect of concomitant mercuric chloride and gentamicin on kidney function and structure in the rat.
    The Journal of laboratory and clinical medicine, 1977, Volume: 89, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Drug Interactions; Gentamicins; Glome

1977
Gentamicin gradient patterns and morphological changes in human kidneys.
    Nephron, 1977, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Aged; Female; Gentamicins; Humans; Kidney; Kidney Cortex; Kidney Medulla; Kidney

1977
[Nephrotoxicity of gentamycin-cephalothin combination therapy].
    Die Medizinische Welt, 1977, Oct-07, Volume: 28, Issue:40

    Topics: Acute Kidney Injury; Animals; Cephalothin; Drug Therapy, Combination; Gentamicins; Kidney Tubular Ne

1977
[Nephortoxicity of a combination of cephalotin and gentamicin].
    Duodecim; laaketieteellinen aikakauskirja, 1976, Volume: 92, Issue:11

    Topics: Acute Kidney Injury; Animals; Cephalothin; Drug Synergism; Drug Therapy, Combination; Female; Furose

1976
Comparative nephrotoxicities of netilmicin and gentamicin in rats.
    Antimicrobial agents and chemotherapy, 1976, Volume: 10, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Dose-Response Relationship, Drug; Gentamicins;

1976
Letter: Gentamicin nephrotoxicity in patients with renal allografts.
    British medical journal, 1975, Nov-22, Volume: 4, Issue:5994

    Topics: Animals; Gentamicins; Humans; Kidney; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Lysoso

1975
Nephrotoxicity of combined cephalothin-gentamicin regimen.
    Archives of internal medicine, 1975, Volume: 135, Issue:6

    Topics: Acute Kidney Injury; Aged; Blood Urea Nitrogen; Bronchopneumonia; Cephalothin; Drug Synergism; Drug

1975
The diagnostic value of enzymuria, cell excretion, and proteinuria in experimental renal diseases.
    Urological research, 1975, May-30, Volume: 3, Issue:1

    Topics: Animals; Clinical Enzyme Tests; Enzymes; Female; Gentamicins; Humans; Kidney Diseases; Kidney Tubula

1975
[The dangers of antibiotic therapy in gram-negative pathogens (author's transl)].
    Der Urologe. Ausg. A, 1976, Volume: 15, Issue:1

    Topics: Acute Kidney Injury; Adult; Anuria; Bacterial Infections; Deafness; Drug Therapy, Combination; Femal

1976
A light and electron microscopic analysis of gentamicin nephrotoxicity in rats.
    The American journal of pathology, 1976, Volume: 82, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Gentamicins; Kidney Tubular Necrosis,

1976
Calcium supplementation and thyroid hormone protect against gentamicin-induced inhibition of proximal tubular Na+,K(+)-ATPase activity and other renal functional changes.
    Acta physiologica Scandinavica, 1992, Volume: 145, Issue:2

    Topics: Acetylglucosaminidase; Animals; Calcium; Gentamicins; Glomerular Filtration Rate; Kidney Tubular Nec

1992
Gentamicin nephrotoxicity in rat: some biochemical correlates.
    Pharmacology & toxicology, 1992, Volume: 70, Issue:6 Pt 1

    Topics: Amine Oxidase (Copper-Containing); Animals; Body Weight; Creatinine; Dose-Response Relationship, Dru

1992
Changes in concentration of essential metals in kidneys and urine as indices of gentamicin nephrotoxicity in female Wistar rats.
    Pharmacology & toxicology, 1992, Volume: 71, Issue:3 Pt 1

    Topics: Animals; Copper; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proxim

1992
Tubular injury and regeneration in the rat kidney following acute exposure to gentamicin: a time-course study.
    Renal failure, 1992, Volume: 14, Issue:4

    Topics: Animals; Epidermal Growth Factor; Female; Gentamicins; Immunohistochemistry; Kidney Tubular Necrosis

1992
Effect of vitamin B6 supplementation on gentamicin nephrotoxicity in rabbits.
    Veterinary and human toxicology, 1992, Volume: 34, Issue:1

    Topics: Animals; Female; Gentamicins; Kidney Tubular Necrosis, Acute; Pyridoxine; Rabbits; Random Allocation

1992
Protective effect of zinc-induced metallothionein synthesis on gentamicin nephrotoxicity in rats.
    Renal failure, 1991, Volume: 13, Issue:4

    Topics: Acute Kidney Injury; Animals; Free Radical Scavengers; Gentamicins; Hydroxides; Hydroxyl Radical; Ki

1991
Urine profiles and kidney histology following intravenous diatrizoate and iohexol in the degeneration phase of gentamicin nephropathy in rats. Effects on urine and serum profiles.
    Investigative radiology, 1991, Volume: 26, Issue:11

    Topics: Animals; Diatrizoate; Enzyme-Linked Immunosorbent Assay; Gentamicins; Iohexol; Kidney; Kidney Tubula

1991
An electron microscopy study of urinary sediment: relationship between myeloid body excretion and gentamicin nephrotoxicity in the rat.
    Renal failure, 1991, Volume: 13, Issue:4

    Topics: Animals; Gentamicins; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Mercuric Chloride; Micro

1991
Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:12

    Topics: Animals; Cisplatin; Creatinine; Gentamicins; Kidney Tubular Necrosis, Acute; Male; Mercuric Chloride

1991
Effect of recombinant human erythropoietin on new anaemic model rats induced by gentamicin.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:11

    Topics: Anemia; Animals; Blood Volume; Erythropoietin; Gentamicins; Hematocrit; Kidney Tubular Necrosis, Acu

1990
Cell injury associated calcium oxalate crystalluria.
    The Journal of urology, 1990, Volume: 144, Issue:6

    Topics: Animals; Calcium Oxalate; Cell Membrane; Crystallization; Ethylene Glycol; Ethylene Glycols; Gentami

1990
Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule.
    Renal failure, 1990, Volume: 12, Issue:2

    Topics: Animals; Gentamicins; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Male; Rats; Rats, In

1990
Lack of effect of glutathione depletion by L-buthionine-S,R-sulfoximine on gentamicin nephrotoxicity in rats.
    Pharmacology, 1990, Volume: 40, Issue:5

    Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Antimetabolites; Buthionine Sulfoximine; Creati

1990
Urinary indices of renal function in sheep with induced aminoglycoside nephrotoxicosis.
    American journal of veterinary research, 1990, Volume: 51, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Glucose; Electrolytes; Female; Gentamicins; Glycosuria; Hyperpla

1990
Enhanced gentamicin nephrotoxicity after experimental biliary obstruction in rats.
    Pharmacology & toxicology, 1989, Volume: 65, Issue:5

    Topics: Animals; Cholestasis; Gentamicins; Kidney; Kidney Diseases; Kidney Tubular Necrosis, Acute; Liver Fu

1989
Diltiazem enhances gentamicin nephrotoxicity in rats.
    Pharmacology & toxicology, 1989, Volume: 64, Issue:2

    Topics: Acute Kidney Injury; Animals; Diltiazem; Drug Synergism; Gentamicins; Kidney Tubular Necrosis, Acute

1989
Influence of hydrocortisone on gentamicin-induced nephrotoxicity in rats.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:7

    Topics: Animals; DNA; DNA Repair; Female; Gentamicins; Histocytochemistry; Hydrocortisone; Infusions, Intrav

1988
Lowered plasma erythropoietin in hypoxic rats with kidney tubule lesions.
    Blut, 1988, Volume: 57, Issue:5

    Topics: Altitude; Animals; Cell Line; Erythropoietin; Gentamicins; Hydronephrosis; Hypoxia; Kidney Tubular N

1988
[Renal disease associated with heroin abuse].
    Nephrologie, 1988, Volume: 9, Issue:5

    Topics: Adult; Endocarditis, Bacterial; Female; Gentamicins; Glomerulonephritis; Heroin; Humans; Hypertensio

1988
Effects of dietary electrolyte supplementation on gentamicin nephrotoxicity.
    The American journal of the medical sciences, 1988, Volume: 295, Issue:5

    Topics: Animals; Diet; Drinking; Drug Evaluation, Preclinical; Drug Interactions; Electrolytes; Gentamicins;

1988
Electrolyte composition of renal tubular cells in gentamicin nephrotoxicity.
    Kidney international, 1988, Volume: 33, Issue:6

    Topics: Acute Kidney Injury; Animals; Electrolytes; Electron Probe Microanalysis; Freeze Drying; Gentamicins

1988
Reduction of gentamicin nephrotoxicity by the concomitant administration of poly-l-aspartic acid and poly-l-asparagine in rats.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1986, Volume: 9

    Topics: Animals; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Peptides; Phospholipids; Rats;

1986