gentamicin has been researched along with Acute Kidney Tubular Necrosis in 78 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in gentamicin-induced acute tubular necrosis in rats using the iNOS inhibitor L-N6-(1-iminoethyl) lysine (L-NIL)." | 7.74 | The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović-Dzuvo, A; Nakas-Ićindić, E; Rasić, S; Valjevac, A; Zaciragić, A, 2007) |
| "The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in gentamicin-induced acute tubular necrosis in rats using the iNOS inhibitor L-N6-(1-iminoethyl) lysine (L-NIL)." | 3.74 | The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović-Dzuvo, A; Nakas-Ićindić, E; Rasić, S; Valjevac, A; Zaciragić, A, 2007) |
| " Six patients had acute tubular necrosis, due to rhabdomyolysis in 5 and to prolonged gentamicin therapy for bacterial endocarditis in 1." | 3.67 | [Renal disease associated with heroin abuse]. ( Beaufils, H; Chauveau, P; Mougenot, B; Pourriat, JL; Rondeau, E; Uzan, M; Viron, B; Volochine, L, 1988) |
| " coli-pyelonephritis facilitated by oestradiolundecylate, aminonucleoside nephrosis, aminoglycoside induced renal lesions and pyelonephritic animals treated with therapeutic and toxic doses of tobramycin." | 3.65 | The diagnostic value of enzymuria, cell excretion, and proteinuria in experimental renal diseases. ( Sack, K; Wilhelm, J, 1975) |
| " To show clinical relevance, we use quantitative systems pharmacology computational models for in vitro-in vivo translation of the experimental results and to identify favorable dosing regimens for one of the tested drugs." | 1.51 | Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System. ( Cirit, M; Himmelfarb, J; Kelly, EJ; Maass, C; Sorensen, NB; Stokes, CL, 2019) |
| "Dipyridamole pretreatment in gentamicin-administered rats afforded a noticeable renoprotection by markedly preventing renal structural and functional abnormalities, renal inflammation and serum uric acid elevation." | 1.46 | Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat. ( Bahari, MB; Balakumar, P; Gan, YS; Jayachristy, SA; JemayPuah, SM; Kuganesswari, S; Prajapati, SK; Sundram, K; Varatharajan, R; WitnessKoe, WE, 2017) |
| " Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage." | 1.42 | Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase. ( Blanco-Gozalo, V; García-Sánchez, O; González-Buitrago, JM; López-Hernández, FJ; López-Novoa, JM; Morales, AI; Pescador, M; Sánchez-Juanes, F; Sevilla, MA; Vicente-Vicente, L, 2015) |
| "Hydrogen sulfide (H2S) is a signaling molecule involved in inflammation." | 1.38 | Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin. ( Chierice, JR; Coimbra, TM; Costa, RS; Cunha, FQ; Francescato, HD; Marin, EC; Silva, CG, 2012) |
| "Rosmarinic acid (RA) has been demonstrated to have antioxidant, free radical scavenger and anti-inflammatory effects." | 1.37 | Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats. ( Ahmadvand, H; Tavafi, M, 2011) |
| " Our results indicated that CAPE acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GEN both at the biochemical and histological level." | 1.33 | Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. ( Acet, A; Bay-Karabulut, A; Parlakpinar, H; Polat, A; Tasdemir, S; Ucar, M; Vardi, N, 2005) |
| "and gentamicin group was injected with gentamicin in the dose of 80 mg/kg/day i." | 1.33 | Nitric oxide in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović, A; Mijanović, M; Nakas-Ićindić, E; Prasović, S; Tahirović, G; Zaciragić, A, 2005) |
| "Gentamicin-treated rats presented a transitory increase in plasma creatinine levels." | 1.33 | Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. ( Balbi, AP; Coimbra, TM; Costa, RS; Volpini, RA, 2006) |
| "Taurine treatment reduced gentamicin-induced increases in serum creatinine, 24 h urine volume, BUN and tissue lactate and TBARS levels (0." | 1.31 | The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. ( Bozkurt, A; Erdem, A; Erdem, SR; Gündoğan, NU; Kara, A; Kilinç, K; Usubütün, A, 2000) |
| "Sonography was performed before and during the onset and progression of nephrotoxicosis induced by administration of a toxic dosage of gentamicin." | 1.29 | Gray-scale sonographic characterization of aminoglycoside-induced nephrotoxicosis in a canine model. ( Finlay, DE; Holm, JC; King, VL; Letourneau, JG; O'Brien, TD; Polzin, DJ; Ritenour, ER; Rivers, BJ; Walter, PA, 1996) |
| "Gentamicin can cause proximal tubule necrosis." | 1.28 | Calcium supplementation and thyroid hormone protect against gentamicin-induced inhibition of proximal tubular Na+,K(+)-ATPase activity and other renal functional changes. ( Aperia, A; Eklöf, AC; Fukuda, Y; Malmborg, AS, 1992) |
| "Gentamicin was injected subcutaneously at 40 mg/kg body weight." | 1.28 | An electron microscopy study of urinary sediment: relationship between myeloid body excretion and gentamicin nephrotoxicity in the rat. ( Bell, RD; Caruso, DE; Hillman, NM; Mandal, AK; Saklayen, MG; Taylor, CA, 1991) |
| "Gentamicin-treated rats showed marked elevation of blood urea nitrogen, extensive tubular necrosis in the kidney and haemosiderin deposition in the spleen." | 1.28 | Effect of recombinant human erythropoietin on new anaemic model rats induced by gentamicin. ( Arai, H; Koumegawa, J; Kusaka, M; Nagano, N; Wada, M, 1990) |
| " These findings suggest that some aspects of the functional or metabolic heterogeneity within the PCT may be related to either differential rates of uptake of the drug or to differences in intrinsic susceptibility to its toxic effects." | 1.28 | Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule. ( Burke, TJ; Shanley, PF, 1990) |
| " Bile duct ligated and gentamicin injected rats elicited a decline in renal function and tubular cell necrosis after 8 days of treatment whereas equal dosage regimen in sham operated rats exhibited no evidence of renal dysfunction." | 1.28 | Enhanced gentamicin nephrotoxicity after experimental biliary obstruction in rats. ( Andrade, RJ; Gonzalez-Correa, JA; Ibañez, J; Lucena, MI; Sanchez de la Cuesta, F; Torres, D, 1989) |
| " We concluded that hydrocortisone interferes with the postnecrotic cellular regeneration process, an important step that is responsible for the recovery of normal kidney structure following toxic injuries associated with aminoglycoside therapy." | 1.27 | Influence of hydrocortisone on gentamicin-induced nephrotoxicity in rats. ( Beauchamp, D; Pettigrew, M, 1988) |
| "The etiology of acute renal failure has changed in recent years due to the recognition of drug nephrotoxicity as a more common cause." | 1.26 | Pathogenesis of renal failure due to aminoglycosides and contrast media used in roentgenography. ( Bennett, WM; Luft, F; Porter, GA, 1980) |
| " An identical dosage of tobramycin was associated with only minimal morphological changes and normal concentrations of serum creatinine and blood urea nitrogen." | 1.26 | Comparative nephrotoxicity of gentamicin and tobramycin in rats. ( Bennet, WM; Gilbert, DN; Houghton, DC; Plamp, C; Porter, G; Starr, P, 1978) |
| "Rats recovering from HgCl2-induced acute renal failure were resistant to a depression in glomerular filtration when given gentamicin." | 1.26 | The effect of concomitant mercuric chloride and gentamicin on kidney function and structure in the rat. ( Kleit, SA; Luft, FC; Yum, MN, 1977) |
| " The morphologically immature regenerating cells are apparently metabolically immature as well and appear not to be susceptible to toxic effects of the drug." | 1.26 | A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. ( Bennett, W; Campbell-Boswell, M; Hartnett, M; Houghton, DC; Porter, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (41.03) | 18.7374 |
| 1990's | 23 (29.49) | 18.2507 |
| 2000's | 14 (17.95) | 29.6817 |
| 2010's | 9 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maass, C | 1 |
| Sorensen, NB | 1 |
| Himmelfarb, J | 1 |
| Kelly, EJ | 1 |
| Stokes, CL | 1 |
| Cirit, M | 1 |
| Vicente-Vicente, L | 1 |
| Sánchez-Juanes, F | 1 |
| García-Sánchez, O | 1 |
| Blanco-Gozalo, V | 1 |
| Pescador, M | 1 |
| Sevilla, MA | 1 |
| González-Buitrago, JM | 1 |
| López-Hernández, FJ | 1 |
| López-Novoa, JM | 1 |
| Morales, AI | 1 |
| Biro, A | 1 |
| Vaknine, H | 1 |
| Cohen-Armon, M | 1 |
| Matas, Z | 1 |
| Fux, A | 1 |
| Schreiber, L | 1 |
| Berger, E | 1 |
| Dan, M | 1 |
| Boaz, M | 1 |
| Gregoriev, O | 1 |
| Katzir, Z | 1 |
| Balakumar, P | 1 |
| WitnessKoe, WE | 1 |
| Gan, YS | 1 |
| JemayPuah, SM | 1 |
| Kuganesswari, S | 1 |
| Prajapati, SK | 1 |
| Varatharajan, R | 1 |
| Jayachristy, SA | 1 |
| Sundram, K | 1 |
| Bahari, MB | 1 |
| Romero, F | 1 |
| Pérez, M | 1 |
| Chávez, M | 1 |
| Parra, G | 1 |
| Durante, P | 1 |
| Ozbek, E | 1 |
| Cekmen, M | 1 |
| Ilbey, YO | 1 |
| Simsek, A | 1 |
| Polat, EC | 1 |
| Somay, A | 1 |
| Cao, J | 1 |
| Yang, XD | 1 |
| Wang, XY | 1 |
| Qu, L | 1 |
| Liu, G | 1 |
| Li, XM | 1 |
| Tavafi, M | 1 |
| Ahmadvand, H | 1 |
| Aksoy, N | 1 |
| Dogan, Y | 1 |
| Iriadam, M | 1 |
| Bitiren, M | 1 |
| Uzer, E | 1 |
| Ozgonul, A | 1 |
| Aksoy, S | 1 |
| Francescato, HD | 1 |
| Chierice, JR | 1 |
| Marin, EC | 1 |
| Cunha, FQ | 1 |
| Costa, RS | 2 |
| Silva, CG | 1 |
| Coimbra, TM | 2 |
| Liu, L | 1 |
| Chen, D | 1 |
| Yi, ZW | 1 |
| Liu, XH | 1 |
| Wu, XC | 1 |
| Dang, XQ | 1 |
| He, QN | 1 |
| He, XJ | 1 |
| Mo, SH | 1 |
| Cunha, MA | 1 |
| Schor, N | 1 |
| Fogo, AB | 1 |
| Kopple, JD | 1 |
| Ding, H | 1 |
| Letoha, A | 1 |
| Ivanyi, B | 1 |
| Qing, DP | 1 |
| Dux, L | 1 |
| Wang, HY | 1 |
| Sonkodi, S | 1 |
| Ziai, SA | 1 |
| Salehian, P | 1 |
| Mahmoudian, M | 1 |
| Parlakpinar, H | 1 |
| Tasdemir, S | 1 |
| Polat, A | 1 |
| Bay-Karabulut, A | 1 |
| Vardi, N | 1 |
| Ucar, M | 1 |
| Acet, A | 1 |
| Nakas-Ićindić, E | 2 |
| Avdagić, N | 2 |
| Mijanović, M | 1 |
| Prasović, S | 1 |
| Zaciragić, A | 2 |
| Hadzović, A | 1 |
| Tahirović, G | 1 |
| Volpini, RA | 1 |
| Balbi, AP | 1 |
| Rasić, S | 1 |
| Hadzović-Dzuvo, A | 1 |
| Valjevac, A | 1 |
| Furuhama, K | 1 |
| Onodera, T | 1 |
| Jao, W | 1 |
| Manaligod, JR | 1 |
| Gerardo, LT | 1 |
| Castillo, MM | 1 |
| Feinfeld, DA | 1 |
| Sherman, RA | 1 |
| Safirstein, R | 1 |
| Ohmi, N | 1 |
| Fuh, VL | 1 |
| Arias, IM | 1 |
| Levine, SD | 1 |
| Kojima, R | 2 |
| Suzuki, Y | 2 |
| Sugarman, A | 1 |
| Brown, RS | 1 |
| Silva, P | 1 |
| Rosen, S | 1 |
| Hirokawa, N | 1 |
| Naruse, T | 1 |
| Weinberg, EH | 1 |
| Field, WE | 1 |
| Gray, WD | 1 |
| Klein, MF | 1 |
| Robbins, GR | 1 |
| Schwartz, E | 1 |
| Belizon, IJ | 1 |
| Chou, S | 1 |
| Porush, JG | 1 |
| Gomez-Leon, G | 1 |
| Shapiro, WB | 1 |
| Bennett, WM | 4 |
| Luft, F | 1 |
| Porter, GA | 3 |
| Reimschuessel, R | 1 |
| Williams, D | 1 |
| Kishore, BK | 1 |
| Van Schepdael, A | 1 |
| Laurent, G | 4 |
| Lambricht, P | 1 |
| Claes, PJ | 1 |
| Piret, J | 1 |
| Tulkens, PM | 2 |
| Maldague, P | 2 |
| Du, XH | 2 |
| Yang, CL | 2 |
| Weir, BA | 1 |
| Mazumdar, DC | 1 |
| Nonclercq, D | 2 |
| Wrona, S | 2 |
| Toubeau, G | 2 |
| Zanen, J | 2 |
| Heuson-Stiennon, JA | 2 |
| Schaudies, RP | 2 |
| Komatsuda, A | 1 |
| Wakui, H | 1 |
| Satoh, K | 1 |
| Yasuda, T | 1 |
| Imai, H | 1 |
| Nakamoto, Y | 1 |
| Miura, AB | 1 |
| Itoh, H | 1 |
| Tashima, Y | 1 |
| Rivers, BJ | 1 |
| Walter, PA | 1 |
| Holm, JC | 1 |
| Letourneau, JG | 1 |
| Finlay, DE | 1 |
| Ritenour, ER | 1 |
| King, VL | 1 |
| O'Brien, TD | 1 |
| Polzin, DJ | 1 |
| Hayashi, M | 1 |
| Numaguchi, M | 1 |
| Watabe, H | 1 |
| Enomoto, H | 1 |
| Yaoi, Y | 1 |
| Erdem, A | 1 |
| Gündoğan, NU | 1 |
| Usubütün, A | 1 |
| Kilinç, K | 1 |
| Erdem, SR | 1 |
| Kara, A | 1 |
| Bozkurt, A | 1 |
| Xie, Y | 1 |
| Nishi, S | 1 |
| Iguchi, S | 1 |
| Imai, N | 1 |
| Sakatsume, M | 1 |
| Saito, A | 1 |
| Ikegame, M | 1 |
| Iino, N | 1 |
| Shimada, H | 1 |
| Ueno, M | 1 |
| Kawashima, H | 1 |
| Arakawa, M | 1 |
| Gejyo, F | 1 |
| Kalaidjieva, VC | 1 |
| Iliev, ZK | 1 |
| Yu, Y | 1 |
| Zheng, F | 1 |
| Bo, Y | 1 |
| Duan, J | 1 |
| Huang, H | 1 |
| Yazaki, T | 1 |
| Yoshiyama, Y | 1 |
| Wong, P | 1 |
| Beauchamp, D | 3 |
| Kanke, M | 1 |
| Plamp, CE | 2 |
| Parker, RA | 1 |
| Gilbert, DN | 4 |
| Houghton, DC | 4 |
| Clark, CH | 1 |
| Reger, K | 1 |
| Plamp, C | 1 |
| Starr, P | 1 |
| Bennet, WM | 1 |
| Porter, G | 2 |
| Luft, FC | 3 |
| Yum, MN | 3 |
| Kleit, SA | 3 |
| Walker, PD | 1 |
| Hautmann, R | 1 |
| Kurth, M | 1 |
| Buss, H | 1 |
| Lutzeyer, W | 1 |
| Valtonen, VV | 1 |
| Pentikäinen, PJ | 1 |
| Wellwood, JM | 1 |
| Thompson, AE | 1 |
| Tighe, JR | 1 |
| Cabanillas, F | 1 |
| Burgos, RC | 1 |
| Rodríguez, C | 1 |
| Baldizón, C | 1 |
| Sack, K | 1 |
| Wilhelm, J | 1 |
| Leisinger, HJ | 1 |
| Hartnett, M | 1 |
| Campbell-Boswell, M | 1 |
| Bennett, W | 1 |
| Fukuda, Y | 1 |
| Eklöf, AC | 1 |
| Malmborg, AS | 1 |
| Aperia, A | 1 |
| Ali, BH | 1 |
| Abdel Gayoum, AA | 1 |
| Bashir, AA | 1 |
| Chmielnicka, J | 1 |
| Szymańska, JA | 1 |
| Brzeźnicka, EA | 1 |
| Kałuzyński, A | 1 |
| Enriquez, JI | 1 |
| Schydlower, M | 1 |
| O'Hair, KC | 1 |
| Keniston, RC | 1 |
| Nadjem, MA | 1 |
| Delgado, I | 1 |
| Zou, WZ | 1 |
| Chen, W | 1 |
| Thomsen, HS | 1 |
| Golman, K | 1 |
| Larsen, S | 1 |
| Hemmingsen, L | 1 |
| Skaarup, P | 1 |
| Mandal, AK | 1 |
| Saklayen, MG | 1 |
| Taylor, CA | 1 |
| Caruso, DE | 1 |
| Hillman, NM | 1 |
| Bell, RD | 1 |
| Swan, SK | 1 |
| Kohlhepp, SJ | 1 |
| Kohnen, PW | 1 |
| Nagano, N | 1 |
| Koumegawa, J | 1 |
| Arai, H | 1 |
| Wada, M | 1 |
| Kusaka, M | 1 |
| Hackett, RL | 1 |
| Shevock, PN | 1 |
| Khan, SR | 1 |
| Shanley, PF | 1 |
| Burke, TJ | 1 |
| Wu, DF | 1 |
| Griffith, OW | 1 |
| Reidenberg, MM | 1 |
| Garry, F | 1 |
| Chew, DJ | 1 |
| Hoffsis, GF | 1 |
| Lucena, MI | 1 |
| Gonzalez-Correa, JA | 1 |
| Andrade, RJ | 1 |
| Ibañez, J | 1 |
| Torres, D | 1 |
| Sanchez de la Cuesta, F | 2 |
| Gomez, A | 1 |
| Martos, F | 1 |
| Garcia, R | 1 |
| Perez, B | 1 |
| Pettigrew, M | 1 |
| Jelkmann, W | 1 |
| Marienhoff, N | 1 |
| Giesselmann, S | 1 |
| Busch, L | 1 |
| Uzan, M | 1 |
| Volochine, L | 1 |
| Rondeau, E | 1 |
| Viron, B | 1 |
| Mougenot, B | 1 |
| Beaufils, H | 1 |
| Pourriat, JL | 1 |
| Chauveau, P | 1 |
| Aynedjian, HS | 1 |
| Nguyen, D | 1 |
| Lee, HY | 1 |
| Sablay, LB | 1 |
| Bank, N | 1 |
| Matsuda, O | 1 |
| Beck, FX | 1 |
| Dörge, A | 1 |
| Thurau, K | 1 |
1 review available for gentamicin and Acute Kidney Tubular Necrosis
| Article | Year |
|---|---|
Toxicity of aminoglycoside antibiotics.
Topics: Aminoglycosides; Animals; Ataxia; Cat Diseases; Cats; Deafness; Dog Diseases; Dogs; Gentamicins; Hea | 1977 |
1 trial available for gentamicin and Acute Kidney Tubular Necrosis
| Article | Year |
|---|---|
Cisplatin-induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cross-Over Studies; Female; Fosfom | 1997 |
76 other studies available for gentamicin and Acute Kidney Tubular Necrosis
| Article | Year |
|---|---|
Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System.
Topics: Biomarkers; Cell Line; Cisplatin; Gentamicins; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney | 2019 |
Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Biomarkers; Cisplatin; Disease Models, Animal; | 2015 |
The effect of poly (ADP-ribose) polymerase inhibition on aminoglycoside-induced acute tubular necrosis in rats.
Topics: Animals; Anti-Bacterial Agents; Benzamides; Creatinine; Dilatation, Pathologic; Drug Interactions; E | 2016 |
Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Creatinine; Cytoprotection; Dipyridamole; Disease Mod | 2017 |
Effect of uric acid on gentamicin-induced nephrotoxicity in rats - role of matrix metalloproteinases 2 and 9.
Topics: Animals; Anti-Bacterial Agents; Gentamicins; Kidney; Kidney Function Tests; Kidney Tubular Necrosis, | 2009 |
Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways.
Topics: Analysis of Variance; Animals; Atorvastatin; Chi-Square Distribution; Disease Models, Animal; Free R | 2009 |
[Differential changes of intrarenal oxygenation in rat models of acute tubular necrosis caused by aristolochic acid and gentamicin].
Topics: Animals; Aristolochic Acids; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Male; Rats; Rats, | 2010 |
Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats.
Topics: Animals; Antioxidants; Biomarkers; Cinnamates; Creatinine; Depsides; Gentamicins; Glutathione; Kidne | 2011 |
Protective and therapeutic effects of licorice in rats with acute tubular necrosis.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Gentamicins; Glutathione; Glycyrrhiza; Kidne | 2012 |
Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin.
Topics: Alkynes; Animals; Anti-Bacterial Agents; Creatinine; Gentamicins; Glycine; Hydrogen Sulfide; Immunoh | 2012 |
Nephroprotective effects of subcapsular transplantation of metanephric mesenchymal cells on gentamicin-induced acute tubular necrosis in rats.
Topics: Animals; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Mesenchymal Stem Cell Transpla | 2012 |
Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calcium; Contrast Media; Disease Models, Animal; Gentamic | 2002 |
Quiz page. Mesangial lupus nephritis, WHO IIb, and severe acute tubular necrosis, secondary to gentamycin toxicity.
Topics: Adult; Diabetes Mellitus; Diagnosis, Differential; Female; Fever; Gentamicins; Glomerular Mesangium; | 2002 |
L-carnitine ameliorates gentamicin-induced renal injury in rats.
Topics: Animals; Carnitine; Dose-Response Relationship, Drug; Drug Administration Schedule; Gentamicins; Inj | 2002 |
Study of serum and tissues angiotensin converting enzyme (ACE) activity in rat with gentamicin induced renal toxicity.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Chromatography, High | 2003 |
Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats.
Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Caffeic Acids; Catalase; Female; Free Radical S | 2005 |
Nitric oxide in gentamicin-induced acute tubular necrosis in rats.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Colorimetry; Disease Models, Animal; Female; Gentamicins | 2005 |
Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Creatinine; Female; Fibrosis; Gentamicins; Immuno | 2006 |
The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats.
Topics: Animals; Enzyme Inhibitors; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Lysine; Mal | 2007 |
[Studies on experimental renal damage in rats. II. beta 2-microglobulin: purification, radioimmunoassay, and urine and serum levels in tubular nephropathy].
Topics: Acute Kidney Injury; Animals; beta 2-Microglobulin; Beta-Globulins; Cephaloridine; Female; Gentamici | 1982 |
Myeloid bodies in drug-induced acute tubular necrosis.
Topics: Acute Kidney Injury; Adult; Chromium; Epithelium; Female; Gentamicins; Humans; Inclusion Bodies; Kid | 1983 |
Urinary ligandin in renal tubular cell injury.
Topics: Animals; Cisplatin; Contrast Media; Gentamicins; Glutathione Transferase; Humans; Kidney; Kidney Tra | 1984 |
[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (1). Nephrotoxicity of gentamicin and mercuric chloride].
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Enzymes; Gentamicins; Kidney; Kidney Tubular Necr | 1984 |
[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (2). Protective effect of latamoxef against gentamicin nephrotoxicity].
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Gen | 1984 |
Features of gentamicin nephrotoxicity and effect of concurrent cephalothin in the rat.
Topics: Acute Kidney Injury; Animals; Cephalothin; Gentamicins; Glomerular Filtration Rate; Kidney; Kidney C | 1983 |
[Clinical evaluation of urinary n-acetyl-beta-d-glucosaminidase activity in patients treated with aminoglycosides].
Topics: Acetylglucosaminidase; Acute Kidney Injury; Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial | 1982 |
Preclinical toxicologic studies of netilmicin.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Dogs; Dose-Response Relationship, Drug; Fema | 1981 |
Recovery without a diuresis after protracted acute tubular necrosis.
Topics: Acute Kidney Injury; Cephalosporins; Cephapirin; Diuresis; Female; Gentamicins; Humans; Kidney Tubul | 1980 |
Pathogenesis of renal failure due to aminoglycosides and contrast media used in roentgenography.
Topics: Acute Kidney Injury; Aminoglycosides; Animals; Contrast Media; Dogs; Gentamicins; Humans; Kidney Tub | 1980 |
Development of new nephrons in adult kidneys following gentamicin-induced nephrotoxicity.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Gentamicins; Goldfish; Immunoh | 1995 |
Co-oxydextran as a protectant against gentamicin-induced renal lysosomal phospholipidosis and focal tubular necrosis. Perspectives and limitations.
Topics: Animals; Anions; Cell Division; Dextrans; Female; Gentamicins; Kidney Diseases; Kidney Tubular Necro | 1993 |
Mechanism of gentamicin nephrotoxicity in rats and the protective effect of zinc-induced metallothionein synthesis.
Topics: Acute Kidney Injury; Animals; DNA; Free Radicals; Gentamicins; Hydroxyl Radical; In Vitro Techniques | 1994 |
Aminoglycoside nephrotoxicity following single-dose cystoscopy prophylaxis.
Topics: Aged; Aged, 80 and over; Cystoscopy; Gentamicins; Humans; Kidney Tubular Necrosis, Acute; Male; Prem | 1994 |
Immunohistochemical study of epidermal growth factor in the rat kidney after gentamicin-induced tubular injury.
Topics: Animals; Epidermal Growth Factor; Female; Gentamicins; Immunohistochemistry; Kidney Tubular Necrosis | 1993 |
Altered localization of 73-kilodalton heat-shock protein in rat kidneys with gentamicin-induced acute tubular injury.
Topics: Animals; Disease Models, Animal; Gentamicins; Heat-Shock Proteins; Kidney Tubular Necrosis, Acute; L | 1993 |
Gray-scale sonographic characterization of aminoglycoside-induced nephrotoxicosis in a canine model.
Topics: Animals; Anti-Bacterial Agents; Biopsy; Dogs; Female; Gentamicins; Image Processing, Computer-Assist | 1996 |
The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats.
Topics: Acute Disease; Animals; Creatinine; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Lac | 2000 |
Expression of osteopontin in gentamicin-induced acute tubular necrosis and its recovery process.
Topics: Animals; Biomarkers; Gentamicins; Hyaluronan Receptors; Kidney; Kidney Tubular Necrosis, Acute; Male | 2001 |
Plasma erythropoietin level in rats after kidney proximal tubular impairment.
Topics: Anemia; Animals; Disease Models, Animal; Erythropoiesis; Erythropoietin; Gentamicins; Hematologic Te | 2000 |
[Changes of prostaglandins in kidney tissue in gentamicin-induced acute renal tubular injury in rats].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Epidermal Growth Factor; Female; Gentamicins; K | 1998 |
Protective effect of fleroxacin against the nephrotoxicity of isepamicin in rats.
Topics: Acetylglucosaminidase; Animals; Blood Urea Nitrogen; Creatinine; Drug Therapy, Combination; Fleroxac | 2002 |
Renal transport of organic acids and bases in aminoglycoside nephrotoxicity.
Topics: Acute Kidney Injury; Aminoglycosides; Animals; Biological Transport; Gentamicins; Kidney; Kidney Fun | 1979 |
Reversibility of gentamicin nephrotoxicity in rats: recovery during continuous drug administration.
Topics: Acute Kidney Injury; Animals; Creatinine; Gentamicins; Kidney Concentrating Ability; Kidney Tubular | 1979 |
Comparative nephrotoxicity of gentamicin and tobramycin in rats.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Kidney; Kidney Tubular Necrosis | 1978 |
The effect of concomitant mercuric chloride and gentamicin on kidney function and structure in the rat.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Drug Interactions; Gentamicins; Glome | 1977 |
Gentamicin gradient patterns and morphological changes in human kidneys.
Topics: Adolescent; Adult; Aged; Female; Gentamicins; Humans; Kidney; Kidney Cortex; Kidney Medulla; Kidney | 1977 |
[Nephrotoxicity of gentamycin-cephalothin combination therapy].
Topics: Acute Kidney Injury; Animals; Cephalothin; Drug Therapy, Combination; Gentamicins; Kidney Tubular Ne | 1977 |
[Nephortoxicity of a combination of cephalotin and gentamicin].
Topics: Acute Kidney Injury; Animals; Cephalothin; Drug Synergism; Drug Therapy, Combination; Female; Furose | 1976 |
Comparative nephrotoxicities of netilmicin and gentamicin in rats.
Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Dose-Response Relationship, Drug; Gentamicins; | 1976 |
Letter: Gentamicin nephrotoxicity in patients with renal allografts.
Topics: Animals; Gentamicins; Humans; Kidney; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Lysoso | 1975 |
Nephrotoxicity of combined cephalothin-gentamicin regimen.
Topics: Acute Kidney Injury; Aged; Blood Urea Nitrogen; Bronchopneumonia; Cephalothin; Drug Synergism; Drug | 1975 |
The diagnostic value of enzymuria, cell excretion, and proteinuria in experimental renal diseases.
Topics: Animals; Clinical Enzyme Tests; Enzymes; Female; Gentamicins; Humans; Kidney Diseases; Kidney Tubula | 1975 |
[The dangers of antibiotic therapy in gram-negative pathogens (author's transl)].
Topics: Acute Kidney Injury; Adult; Anuria; Bacterial Infections; Deafness; Drug Therapy, Combination; Femal | 1976 |
A light and electron microscopic analysis of gentamicin nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Gentamicins; Kidney Tubular Necrosis, | 1976 |
Calcium supplementation and thyroid hormone protect against gentamicin-induced inhibition of proximal tubular Na+,K(+)-ATPase activity and other renal functional changes.
Topics: Acetylglucosaminidase; Animals; Calcium; Gentamicins; Glomerular Filtration Rate; Kidney Tubular Nec | 1992 |
Gentamicin nephrotoxicity in rat: some biochemical correlates.
Topics: Amine Oxidase (Copper-Containing); Animals; Body Weight; Creatinine; Dose-Response Relationship, Dru | 1992 |
Changes in concentration of essential metals in kidneys and urine as indices of gentamicin nephrotoxicity in female Wistar rats.
Topics: Animals; Copper; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proxim | 1992 |
Tubular injury and regeneration in the rat kidney following acute exposure to gentamicin: a time-course study.
Topics: Animals; Epidermal Growth Factor; Female; Gentamicins; Immunohistochemistry; Kidney Tubular Necrosis | 1992 |
Effect of vitamin B6 supplementation on gentamicin nephrotoxicity in rabbits.
Topics: Animals; Female; Gentamicins; Kidney Tubular Necrosis, Acute; Pyridoxine; Rabbits; Random Allocation | 1992 |
Protective effect of zinc-induced metallothionein synthesis on gentamicin nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Free Radical Scavengers; Gentamicins; Hydroxides; Hydroxyl Radical; Ki | 1991 |
Urine profiles and kidney histology following intravenous diatrizoate and iohexol in the degeneration phase of gentamicin nephropathy in rats. Effects on urine and serum profiles.
Topics: Animals; Diatrizoate; Enzyme-Linked Immunosorbent Assay; Gentamicins; Iohexol; Kidney; Kidney Tubula | 1991 |
An electron microscopy study of urinary sediment: relationship between myeloid body excretion and gentamicin nephrotoxicity in the rat.
Topics: Animals; Gentamicins; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Mercuric Chloride; Micro | 1991 |
Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity.
Topics: Animals; Cisplatin; Creatinine; Gentamicins; Kidney Tubular Necrosis, Acute; Male; Mercuric Chloride | 1991 |
Effect of recombinant human erythropoietin on new anaemic model rats induced by gentamicin.
Topics: Anemia; Animals; Blood Volume; Erythropoietin; Gentamicins; Hematocrit; Kidney Tubular Necrosis, Acu | 1990 |
Cell injury associated calcium oxalate crystalluria.
Topics: Animals; Calcium Oxalate; Cell Membrane; Crystallization; Ethylene Glycol; Ethylene Glycols; Gentami | 1990 |
Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule.
Topics: Animals; Gentamicins; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Male; Rats; Rats, In | 1990 |
Lack of effect of glutathione depletion by L-buthionine-S,R-sulfoximine on gentamicin nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Antimetabolites; Buthionine Sulfoximine; Creati | 1990 |
Urinary indices of renal function in sheep with induced aminoglycoside nephrotoxicosis.
Topics: Acute Kidney Injury; Animals; Blood Glucose; Electrolytes; Female; Gentamicins; Glycosuria; Hyperpla | 1990 |
Enhanced gentamicin nephrotoxicity after experimental biliary obstruction in rats.
Topics: Animals; Cholestasis; Gentamicins; Kidney; Kidney Diseases; Kidney Tubular Necrosis, Acute; Liver Fu | 1989 |
Diltiazem enhances gentamicin nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Diltiazem; Drug Synergism; Gentamicins; Kidney Tubular Necrosis, Acute | 1989 |
Influence of hydrocortisone on gentamicin-induced nephrotoxicity in rats.
Topics: Animals; DNA; DNA Repair; Female; Gentamicins; Histocytochemistry; Hydrocortisone; Infusions, Intrav | 1988 |
Lowered plasma erythropoietin in hypoxic rats with kidney tubule lesions.
Topics: Altitude; Animals; Cell Line; Erythropoietin; Gentamicins; Hydronephrosis; Hypoxia; Kidney Tubular N | 1988 |
[Renal disease associated with heroin abuse].
Topics: Adult; Endocarditis, Bacterial; Female; Gentamicins; Glomerulonephritis; Heroin; Humans; Hypertensio | 1988 |
Effects of dietary electrolyte supplementation on gentamicin nephrotoxicity.
Topics: Animals; Diet; Drinking; Drug Evaluation, Preclinical; Drug Interactions; Electrolytes; Gentamicins; | 1988 |
Electrolyte composition of renal tubular cells in gentamicin nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Electrolytes; Electron Probe Microanalysis; Freeze Drying; Gentamicins | 1988 |
Reduction of gentamicin nephrotoxicity by the concomitant administration of poly-l-aspartic acid and poly-l-asparagine in rats.
Topics: Animals; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Peptides; Phospholipids; Rats; | 1986 |