gentamicin has been researched along with Absent Iris in 3 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Congenital aniridia is a severe ocular abnormality characterized by incomplete formation of the iris and many other ocular complications." | 1.56 | Nonsense suppression induced readthrough of a novel PAX6 mutation in patient-derived cells of congenital aniridia. ( Gao, H; Liu, X; Qiu, C; Zhang, B; Zhang, Y, 2020) |
| "Aniridia is a panocular disorder that severely affects vision in early life." | 1.40 | Toward postnatal reversal of ocular congenital malformations. ( Marazova, K; Sahel, JA, 2014) |
| " Here, we used a mouse model of aniridia to test the hypothesis that manipulation of Pax6 dosage through a mutation-independent nonsense mutation suppression strategy would limit progressive, postnatal damage in the eye." | 1.40 | Postnatal manipulation of Pax6 dosage reverses congenital tissue malformation defects. ( Gregory-Evans, CY; Gregory-Evans, K; Metcalfe, AL; Wang, X; Wasan, KM; Zhao, J, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Zhang, Y | 1 |
| Zhang, B | 1 |
| Gao, H | 1 |
| Qiu, C | 1 |
| Sahel, JA | 1 |
| Marazova, K | 1 |
| Gregory-Evans, CY | 1 |
| Wang, X | 1 |
| Wasan, KM | 1 |
| Zhao, J | 1 |
| Metcalfe, AL | 1 |
| Gregory-Evans, K | 1 |
3 other studies available for gentamicin and Absent Iris
| Article | Year |
|---|---|
Nonsense suppression induced readthrough of a novel PAX6 mutation in patient-derived cells of congenital aniridia.
Topics: Adult; Aniridia; Cells, Cultured; Child; Female; Gentamicins; Haploinsufficiency; Heterozygote; Huma | 2020 |
Toward postnatal reversal of ocular congenital malformations.
Topics: Animals; Aniridia; Eye Proteins; Gentamicins; Homeodomain Proteins; Oxadiazoles; Paired Box Transcri | 2014 |
Postnatal manipulation of Pax6 dosage reverses congenital tissue malformation defects.
Topics: Animals; Aniridia; Chemistry, Pharmaceutical; Codon, Nonsense; Cornea; Eye Proteins; Gene Dosage; Ge | 2014 |