genkwanin and African-Swine-Fever
genkwanin has been researched along with African-Swine-Fever* in 1 studies
Other Studies
1 other study(ies) available for genkwanin and African-Swine-Fever
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Inhibition of African swine fever virus infection by genkwanin.
African swine fever virus (ASFV) is the causative agent of an economically important disease of pigs for which no effective vaccines or antiviral drugs are available. Recent outbreaks in EU countries and China have highlighted the critical role of antiviral research in combating this disease. We have previously shown that apigenin, a naturally occurring plant flavone, possesses significant anti-ASFV activity. However, apigenin is practically insoluble in highly polar solvents and it occurs typically in derivative forms in plants. Here we screened several commercially available apigenin derivatives for their ability to inhibit ASFV Ba71V strain in Vero cells. Among them, genkwanin showed significant inhibition of ASFV, reducing viral titer from 6.5 ± 0.1 to 4.75 ± 0.25 log TCID/ml in a dose-dependent manner (IC Topics: African Swine Fever; African Swine Fever Virus; Animals; Antiviral Agents; Apigenin; Chlorocebus aethiops; Flavones; Swine; Vero Cells; Virus Internalization; Virus Release | 2019 |