genistein and Central-Nervous-System-Diseases

genistein has been researched along with Central-Nervous-System-Diseases* in 1 studies

Other Studies

1 other study(ies) available for genistein and Central-Nervous-System-Diseases

Article	Year
Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes. Journal of medicinal chemistry, 2002, Mar-28, Volume: 45, Issue:7 In an effort to identify selective ligands for the estrogen receptor subtype ERbeta, a series of aryl benzthiophenes was synthesized. In a radioligand binding assay and reporter gene assays in HeLa and SH-SY5Y cells, compounds were characterized as ERbeta-selective agonists. By targeting ERbeta in the brain, these compounds could lead to drugs able to separate the beneficial effects of estrogens on mood, learning, and memory from side effects such as the stimulation of endometrial and breast cancer. Topics: Amino Acid Motifs; Binding Sites; Central Nervous System Diseases; Crystallography, X-Ray; Estrogen Receptor beta; HeLa Cells; Humans; Ligands; Models, Chemical; Models, Molecular; Protein Structure, Tertiary; Receptors, Estrogen; Thiophenes; Tumor Cells, Cultured	2002

Article

Year

Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.

Journal of medicinal chemistry, 2002, Mar-28, Volume: 45, Issue:7

In an effort to identify selective ligands for the estrogen receptor subtype ERbeta, a series of aryl benzthiophenes was synthesized. In a radioligand binding assay and reporter gene assays in HeLa and SH-SY5Y cells, compounds were characterized as ERbeta-selective agonists. By targeting ERbeta in the brain, these compounds could lead to drugs able to separate the beneficial effects of estrogens on mood, learning, and memory from side effects such as the stimulation of endometrial and breast cancer.

Topics: Amino Acid Motifs; Binding Sites; Central Nervous System Diseases; Crystallography, X-Ray; Estrogen Receptor beta; HeLa Cells; Humans; Ligands; Models, Chemical; Models, Molecular; Protein Structure, Tertiary; Receptors, Estrogen; Thiophenes; Tumor Cells, Cultured

2002