geniposide has been researched along with Disease Models, Animal in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (5.66) | 29.6817 |
| 2010's | 38 (71.70) | 24.3611 |
| 2020's | 12 (22.64) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, Y; Gao, H; Ma, WW; Wang, Y; Xie, ZL; Yao, XS; Yu, Y; Zhong, Y | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cao, Y; Chen, X; Ding, Y; Li, Q; Li, Y; Qiu, H; Yao, S; Zhu, X | 1 |
| Chen, Z; Jin, Q; Li, L; Liu, H; Ouyang, J; Shi, W; Wu, L; Xiao, Y; Xu, D; Zhang, D; Zhang, R; Zhang, S; Zheng, Y | 1 |
| da SilvaTorres, IL; de Oliveira, JDM; Medeiros, HR; Pereira, P; Pflüger, P; Picada, JN; Uczay, M; Vendruscolo, MH; von Poser, G | 1 |
| Bian, Y; Dou, DH; Gu, Y; Shi, JX; Shi, L; Yu, B; Yu, Y; Yuan, DP | 1 |
| Chae, HJ; Lee, GH; Lee, HY; Yoon, Y | 1 |
| Feng, F; Zhang, Q | 1 |
| Gao, W; Li, L; Liu, Y; Wang, X; Zhang, D; Zhang, Z | 1 |
| Han, ZF; Li, LJ; Li, LX; Yan, B | 1 |
| Cao, YG; Feng, WS; Fu, Y; Hou, Y; Ke, YY; Yuan, PP; Zhang, Q; Zhang, YL; Zheng, XK | 1 |
| Li, C; Liu, Y; Pu, Z; Xie, H; Xu, M; Zhao, J | 1 |
| Dusabimana, T; Je, J; Jeong, K; Kim, H; Kim, HJ; Park, EJ; Park, SW; Yun, SP | 1 |
| Chen, R; He, P; Li, R; Lin, Y; Liu, Y; Wen, M; Wu, F | 1 |
| Gu, J; Li, L; Liu, X; Liu, Y; Qin, B; Qiu, Z; Sang, A; Zhou, Y; Zhu, M | 1 |
| Baker, RD; Baker, SS; Chen, C; Feng, Q; Guan, L; Hu, Y; Kozielski, R; Li, H; Liu, P; Liu, Q; Liu, W; Peng, J; Tang, S; Tsompana, M; Zhu, L; Zhu, R | 1 |
| Cao, Y; Fu, Y; Li, S; Li, Y; Liu, B; Liu, J; Lu, X; Shen, P; Zhang, N; Zhang, Z | 1 |
| Feng, X; Gao, Y; Han, J; La Frano, MR; Li, C; Li, G; Li, X; Liang, A; Liu, J; Newman, JW; Pan, C; Tian, J; Wang, L; Xiang, S; Yi, Y; Zhang, Y; Zhao, Y; Zhu, J | 1 |
| Hou, J; Lei, H; Li, D; Wang, J | 1 |
| Ma, WW; Peng, IF; Tao, Y; Wang, YY | 1 |
| Li, B; Liu, J; Liu, Q; Wang, PQ; Wang, Z; Xu, WJ; Yu, YN; Zhang, YY | 1 |
| Cui, H; Deng, M; Liu, J; Yin, F; Zhang, Y | 1 |
| Dai, L; Deng, R; Fu, J; Li, F; Wang, W; Wu, H; Zhang, Y; Zhang, Z | 1 |
| Li, B; Li, H; Liu, J; Wang, J; Wang, P; Wang, Z; Yu, Y; Zhang, Y | 1 |
| Feng, F; Wang, Y | 1 |
| Bai, Y; Dai, G; Jing, W; Ju, W; Song, L; Song, S; Sun, H; Xu, M; Zhang, W; Zhang, Y | 1 |
| Cheng, W; Li, P; Liu, J; Wang, Y; Zhang, J; Zhang, Z | 1 |
| Deng, X; Deng, Y; Guan, M; Li, H; Wang, D; Wei, J; Xiang, H; Xie, X; Yang, X; Zou, L | 1 |
| Ding, J; Gao, C; Jiang, Y; Li, L; Liu, Y | 1 |
| Chen, YY; Fang, H; Jing, ZW; Li, HX; Liu, J; Wang, YY; Wang, Z; Yu, YN; Zhang, YY | 1 |
| Bai, J; Cao, YF; Du, Q; Du, SY; Guo, YW; Lu, Y; Xu, P | 1 |
| Lu, J; Pan, L; Tian, X; Wang, W; Zeng, M; Zhang, M; Zhou, J; Zhu, H | 1 |
| Chen, T; Liu, H; Liu, X; Lv, C; Zhang, W | 1 |
| Liu, X; Lv, C; Wang, L; Wang, Y; Yan, S; Yan, SS; Zhang, W | 1 |
| Chen, J; Chen, JY; Dai, MM; Hu, SL; Li, H; Wu, H | 1 |
| Guo, L; Liu, J; Liu, Z; Xia, Z; Yin, F; Zhang, Y; Zidichouski, J | 1 |
| Cai, L; Hu, XY; Li, R; Meng, G; Tang, WJ; Wu, TN | 1 |
| Cai, L; Hu, CM; Lei, C; Li, R; Tang, WJ; Yu, F | 1 |
| Chen, Y; Hölscher, C; Li, L; Zhang, Y | 1 |
| Liu, J; Liu, Z; Yin, F; Zhang, Y | 1 |
| Gao, X; Lu, Z; Peng, L; Qin, L; Song, Y; Wang, Q; Zhang, Q; Zhang, Z | 1 |
| Dang, H; Guo, S; Li, B; Li, H; Liu, J; Wang, L; Wang, Y; Wang, Z; Wu, H; Yu, Y; Zhang, Y | 1 |
| Lou, J; Su, C; Yang, X | 1 |
| Kong, L; Li, P; Liao, S; Lv, Y; Wang, J; Xu, D; Yang, M; Zhang, C; Zhang, Q | 1 |
| Guan, Y; Han, Y; Qiu, S; Sun, H; Wang, X; Zhang, A; Zhang, T | 1 |
| Li, H; Li, Z; Liu, X; Lv, C; Wang, Y; Xin, W; Zhang, H; Zhang, W; Zhao, C | 1 |
| He, R; Jin, Y; Wang, Y; Xie, W | 1 |
| Huang, C; Li, J; Ma, T; Meng, X; Tang, W; Zha, D; Zong, G | 1 |
| Hongyu, L; Jing, L; Jingping, H; Jingyuan, W; Lanxiang, J; Meixia, H; Miaomiao, W; Qinren, C; Xiangru, F; Xianxing, X; Xiao, C; Xiaofeng, Y; Xinxin, C; Xuming, D; Yanhong, D | 1 |
| Li, J; Meng, FY; Wang, CM; Wang, YY; Wang, Z; Wu, RG; Zhang, ZJ | 1 |
| Liu, H; Wei, SF; Yang, M; Zhang, HY | 1 |
| Li, P; Li, PT; Sun, ZH; Wang, YY; Wang, Z; Zhang, WS; Zhang, XJ; Zhang, ZJ | 1 |
| Ikeda, Y; Kondo, K; Suzuki, Y; Umemura, K | 1 |
53 other study(ies) available for geniposide and Disease Models, Animal
| Article | Year |
|---|---|
Bioactive iridoid glucosides from the fruit of Gardenia jasminoides.
Topics: Alzheimer Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila; Fruit; Gardenia; Iridoids; Memory, Short-Term; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism | 2009 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Geniposide exerts protective effects on spinal cord injury in rats by inhibiting the IKKs/NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Female; I-kappa B Kinase; Inflammation Mediators; Iridoids; Motor Activity; NF-kappa B; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Spinal Cord Regeneration | 2021 |
Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter 1; Cell Differentiation; Cholesterol; Dexamethasone; Disease Models, Animal; Eucommiaceae; Gene Expression Regulation; Glucagon-Like Peptide-1 Receptor; Iridoids; Mice; Osteoblasts; Osteoporosis; Rats; Signal Transduction | 2021 |
Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hippocampus; Iridoids; Mice; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2023 |
Geniposide promotes splenic Treg differentiation to alleviate colonic inflammation and intestinal barrier injury in ulcerative colitis mice.
Topics: Animals; Caco-2 Cells; Cell Differentiation; Colitis, Ulcerative; Disease Models, Animal; Forkhead Transcription Factors; Humans; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Spleen; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha | 2022 |
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diet, High-Fat; Disease Models, Animal; Endoplasmic Reticulum Stress; Eucommiaceae; Fatty Liver; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Rats, Sprague-Dawley; Reactive Oxygen Species | 2019 |
The Effects of Different Varieties of
Topics: Animals; Chromatography, High Pressure Liquid; Depression; Disaccharides; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Flavanones; Hesperidin; Intestinal Absorption; Iridoids; Male; Rats; Rats, Sprague-Dawley | 2019 |
Geniposide effectively reverses cognitive impairment and inhibits pathological cerebral damage by regulating the mTOR Signal pathway in APP∕PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Iridoids; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
[Effects of Geniposide on the Neuroinflammation in Chronic Cerebral Hypoperfusion Rat Model].
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cognition Disorders; Disease Models, Animal; Hippocampus; Iridoids; Maze Learning; Random Allocation; Rats | 2020 |
Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cell Line; Disease Models, Animal; Diuresis; Diuretics; Estrogen Receptor alpha; Estrogen Receptor beta; Gardenia; Hypertension; Iridoids; Kidney Tubules, Proximal; Male; Plant Extracts; Protein Serine-Threonine Kinases; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction | 2020 |
Using Network Pharmacology for Systematic Understanding of Geniposide in Ameliorating Inflammatory Responses in Colitis Through Suppression of NLRP3 Inflammasome in Macrophage by AMPK/Sirt1 Dependent Signaling.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Colitis; Disease Models, Animal; Inflammasomes; Inflammation; Iridoids; Macrophages; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Phytotherapy; RAW 264.7 Cells; Signal Transduction; Sirtuin 1 | 2020 |
Geniposide Improves Diabetic Nephropathy by Enhancing ULK1-Mediated Autophagy and Reducing Oxidative Stress through AMPK Activation.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Autophagy; Autophagy-Related Protein-1 Homolog; Cyclic AMP-Dependent Protein Kinases; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, High-Fat; Disease Models, Animal; Fibrosis; Glycogen Synthase Kinase 3 beta; Iridoids; Mice; Mice, Inbred C57BL; Oxidative Stress | 2021 |
Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis.
Topics: Animals; Cholangitis, Sclerosing; Disease Models, Animal; Iridoids; Liver; Mice; Mice, Knockout | 2021 |
Geniposide alleviates choroidal neovascularization by downregulating HB-EGF release from RPE cells by downregulating the miR-145-5p/NF-κB axis.
Topics: Animals; Cells, Cultured; Choroidal Neovascularization; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Iridoids; Male; Mice; MicroRNAs; Retinal Pigment Epithelium | 2021 |
Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease.
Topics: Animals; Chlorogenic Acid; Colon; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Glutathione; Humans; Intestinal Mucosa; Iridoids; Lipid Metabolism; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Signal Transduction; T-Lymphocytes, Regulatory; Transcriptome | 2017 |
Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Inflammation Mediators; Intestinal Mucosa; Iridoids; Male; Mice; Mice, Inbred C57BL; NF-kappa B; PPAR gamma; Signal Transduction | 2017 |
Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Early Diagnosis; gamma-Glutamyltransferase; Gene Expression Regulation; Iridoids; Male; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2017 |
Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA‑155‑5p inhibition.
Topics: Animals; Brain; Brain Ischemia; CD11b Antigen; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Ginsenosides; Glucose; Infarction, Middle Cerebral Artery; Iridoids; Male; Microglia; MicroRNAs; Neuroprotective Agents; Panax notoginseng; Rats; Rats, Sprague-Dawley | 2018 |
Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antimicrobial Cationic Peptides; Brain; Cognition; Disease Models, Animal; Drosophila; Drosophila Proteins; Gardenia; Gene Expression Regulation; Immunity, Innate; Iridoids; Plant Extracts; Polymerase Chain Reaction | 2017 |
Pure mechanistic analysis of additive neuroprotective effects between baicalin and jasminoidin in ischemic stroke mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Hippocampus; Immunity, Innate; Infarction, Middle Cerebral Artery; Iridoids; Male; Mice; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Phenotype; RNA, Messenger; Signal Transduction; Systems Biology; Transcriptome | 2018 |
Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Iridoids; Neurons; Rats, Sprague-Dawley; Signal Transduction; Ubiquitin-Protein Ligases; Unfolded Protein Response | 2018 |
A Microdialysis in Adjuvant Arthritic Rats for Pharmacokinetics⁻Pharmacodynamics Modeling Study of Geniposide with Determination of Drug Concentration and Efficacy Levels in Dialysate.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chromatography, High Pressure Liquid; Dialysis Solutions; Dinoprostone; Disease Models, Animal; Iridoids; Knee Joint; Male; Microdialysis; Rats; Tandem Mass Spectrometry; Treatment Outcome | 2018 |
Gene Expression Profiling Confirms the Dosage-Dependent Additive Neuroprotective Effects of Jasminoidin in a Mouse Model of Ischemia-Reperfusion Injury.
Topics: Animals; Cerebrovascular Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation; Humans; Iridoids; Male; Mice; Reperfusion Injury | 2018 |
Evaluation of the Hepatotoxicity of the Zhi-Zi-Hou-Po Decoction by Combining UPLC-Q-Exactive-MS-Based Metabolomics and HPLC-MS/MS-Based Geniposide Tissue Distribution.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Computational Biology; Disease Models, Animal; Drugs, Chinese Herbal; Iridoids; Liver; Metabolic Networks and Pathways; Metabolome; Metabolomics; Rats; Reproducibility of Results; Tandem Mass Spectrometry; Tissue Distribution | 2019 |
Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi-Zi-Hou-Po decoction in normal and corticosterone-induced depressive rats.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Corticosterone; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Hesperidin; Iridoids; Lignans; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2019 |
Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats.
Topics: Alzheimer Disease; Animals; Cholic Acid; Dementia; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Flavonoids; Humans; Ibotenic Acid; Iridoids; Male; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Rats | 2013 |
Geniposide inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Iridoids; Lung; Mice; Mice, Inbred BALB C; Ovalbumin | 2013 |
Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model.
Topics: Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Apoptosis; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Iridoids; Male; Maze Learning; Memory Disorders; Microscopy, Electron, Transmission; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; tau Proteins; Vacuoles | 2014 |
Convergent and divergent pathways decoding hierarchical additive mechanisms in treating cerebral ischemia-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Therapy, Combination; Drugs, Chinese Herbal; Flavonoids; Infarction, Middle Cerebral Artery; Iridoids; Male; Mice; Mice, Inbred Strains; Microarray Analysis; Molecular Sequence Data; Principal Component Analysis; Reperfusion Injury; Signal Transduction | 2014 |
The effect of stroke and other components in Xing-Nao-Jing on the pharmacokinetics of geniposide.
Topics: Animals; Area Under Curve; Camphanes; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Gardenia; Iridoids; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Stroke | 2014 |
Study on integrated pharmacokinetics of gardenia acid and geniposide: time-antioxidant efficacy after oral administration of Huanglian-Zhizi couplet medicine from Huang-Lian-Jie-Du-Tang in MCAO rats.
Topics: Administration, Oral; Animals; Antioxidants; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Infarction, Middle Cerebral Artery; Iridoids; Phytotherapy; Rats, Sprague-Dawley; Superoxide Dismutase; Time Factors | 2014 |
Geniposide attenuates mitochondrial dysfunction and memory deficits in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Electron Transport Complex IV; Humans; Iridoids; Male; Malondialdehyde; Maze Learning; Membrane Potential, Mitochondrial; Memory Disorders; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Nootropic Agents; Oxidative Stress; Presenilin-1; Random Allocation; Reactive Oxygen Species | 2014 |
Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model.
Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; Iridoids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Treatment Outcome | 2015 |
Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Proliferation; Cells, Cultured; Colon; Cytokines; Disease Models, Animal; Fibroblasts; Freund's Adjuvant; Fruit; Gardenia; Humans; Iridoids; Male; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Rats; Rats, Sprague-Dawley; Signal Transduction; Synovial Membrane | 2015 |
Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Humans; Insulin; Iridoids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments; Presenilin-1 | 2015 |
Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis.
Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Corticotropin-Releasing Hormone; Depressive Disorder; Dietary Sucrose; Disease Models, Animal; Dose-Response Relationship, Drug; Feeding Behavior; Hypothalamo-Hypophyseal System; Iridoids; Male; Motor Activity; Pituitary-Adrenal System; Rats, Sprague-Dawley; Receptors, Glucocorticoid; RNA, Messenger; Stress, Psychological; Uncertainty | 2015 |
Apoptotic Effect of Geniposide on Fibroblast-Like Synoviocytes in Rats with Adjuvant-Induced Arthritis via Inhibiting ERK Signal Pathway In Vitro.
Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; bcl-2-Associated X Protein; Caspase 3; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flow Cytometry; Iridoids; Male; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synovial Membrane | 2016 |
Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; Iridoids; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Neuroprotective Agents; Parkinson Disease; Pars Compacta; Proto-Oncogene Proteins c-bcl-2; Psychomotor Performance; Swimming; Tyrosine 3-Monooxygenase | 2015 |
Geniposide Attenuates the Phosphorylation of Tau Protein in Cellular and Insulin-deficient APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Humans; Insulin; Iridoids; Mice; Mice, Transgenic; Phosphorylation; Presenilin-1; tau Proteins | 2016 |
Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats.
Topics: Animals; Antipyretics; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fever; Flavonoids; Iridoids; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley | 2016 |
Vertical and Horizontal Convergences of Targeting Pathways in Combination Therapy with Baicalin and Jasminoidin for Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Flavonoids; Gene Expression; Iridoids; Male; Mice; Microarray Analysis; Random Allocation; Reperfusion Injury | 2016 |
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.
Topics: alpha-Synuclein; Animals; Cell Line, Tumor; Disease Models, Animal; Dopaminergic Neurons; Humans; Iridoids; Lysosomal-Associated Membrane Protein 2; Mice; MicroRNAs; Neuroprotective Agents; Parkinson Disease; Parkinsonian Disorders; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
The components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model.
Topics: Animals; Berberine; Brain; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Flavonoids; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Iridoids; Male; Metabolomics; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Plants, Medicinal; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chromatography coupled to high resolution mass spectrometry.
Topics: Animals; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cluster Analysis; Disease Models, Animal; Ethanol; Immunohistochemistry; Iridoids; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Mice; Phenotype | 2016 |
Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Brain; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Iridoids; Male; MAP Kinase Signaling System; Memory Disorders; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Receptor for Advanced Glycation End Products | 2017 |
[Effects of geniposide on treating experimental chronic prostatitis rats].
Topics: Animals; Body Weight; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Iridoids; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Leukocyte Count; Male; Prostate; Prostatitis; Rats; Rats, Sprague-Dawley | 2010 |
Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Cytochrome P-450 CYP2E1; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Liver; Insulin; Iridoids; Lipid Metabolism; Male; Malondialdehyde; Non-alcoholic Fatty Liver Disease; PPAR alpha; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2011 |
Geniposide, an iridoid glucoside derived from Gardenia jasminoides, protects against lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Gardenia; Iridoid Glucosides; Iridoids; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Peroxidase; Plants, Medicinal; Random Allocation; Signal Transduction | 2012 |
Synergism and rules from combination of Baicalin, Jasminoidin and Desoxycholic acid in refined Qing Kai Ling for treat ischemic stroke mice model.
Topics: Animals; Cluster Analysis; Computational Biology; Deoxycholic Acid; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Iridoids; Ischemia; Male; Mice; Models, Statistical; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Principal Component Analysis; Stroke | 2012 |
Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent.
Topics: Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Aspirin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Fruit; Gardenia; Iridoids; Male; Mice; Mice, Inbred ICR; Plant Extracts; Plants, Medicinal; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Solvents; Time Factors; Venous Thrombosis; Water | 2013 |
A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury.
Topics: Analysis of Variance; Animals; Brain; Brain Ischemia; Brain-Derived Neurotrophic Factor; Caspase 3; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Drugs, Chinese Herbal; Flavonoids; Iridoids; Male; Neuroprotective Agents; Nimodipine; Pyrans; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Statistics, Nonparametric | 2006 |
Antithrombotic effect of geniposide and genipin in the mouse thrombosis model.
Topics: Animals; Disease Models, Animal; Fibrinolytic Agents; Fruit; Iridoid Glycosides; Iridoids; Male; Mice; Phospholipases A; Phytotherapy; Plant Extracts; Platelet Aggregation; Pyrans; Rubiaceae; Thrombosis | 2001 |