gemfibrozil has been researched along with Renal Insufficiency in 8 studies
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gemfibrozil-statin combination therapy is a well-known risk factor for myopathy and rhabdomyolysis." | 7.70 | A case with severe rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy--a case report. ( Boran, M; Gökçe, V; Koçak, B; Korkmaz, S; Ozdemir, O; Uzun, Y, 2000) |
| "Gemfibrozil-statin combination therapy is a well-known risk factor for myopathy and rhabdomyolysis." | 3.70 | A case with severe rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy--a case report. ( Boran, M; Gökçe, V; Koçak, B; Korkmaz, S; Ozdemir, O; Uzun, Y, 2000) |
| " Adverse events occur more often with the statins that are metabolized via the CYP enzyme system and its 3A4, 2C9 or 2C19 paths." | 2.41 | Lipid-lowering drugs: are adverse effects predictable and reversible? ( Muscari, A; Puddu, GM; Puddu, P, 2002) |
| "We previously verified a physiologically based pharmacokinetic (PBPK) model for mirabegron in healthy subjects using the Simcyp Simulator by incorporating data on the inhibitory effect on cytochrome P450 (CYP) 2D6 and a multi-elimination pathway mediated by CYP3A4, uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B7 and butyrylcholinesterase (BChE)." | 1.51 | Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. ( Konishi, K; Minematsu, T; Nagasaka, Y; Tabata, K, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Behiry, S | 1 |
| Rabie, A | 1 |
| Kora, M | 1 |
| Ismail, W | 1 |
| Sabry, D | 1 |
| Zahran, A | 1 |
| Konishi, K | 1 |
| Minematsu, T | 1 |
| Nagasaka, Y | 1 |
| Tabata, K | 1 |
| Farswan, M | 1 |
| Rathod, SP | 1 |
| Upaganlawar, AB | 1 |
| Semwal, A | 1 |
| Irish, AB | 1 |
| Thompson, CH | 1 |
| Pogson, GW | 1 |
| Kindred, LH | 1 |
| Carper, BG | 1 |
| Ozdemir, O | 1 |
| Boran, M | 1 |
| Gökçe, V | 1 |
| Uzun, Y | 1 |
| Koçak, B | 1 |
| Korkmaz, S | 1 |
| Tsimihodimos, V | 1 |
| Miltiadous, G | 1 |
| Bairaktari, E | 1 |
| Elisaf, M | 1 |
| Muscari, A | 1 |
| Puddu, GM | 1 |
| Puddu, P | 1 |
1 review available for gemfibrozil and Renal Insufficiency
| Article | Year |
|---|---|
Lipid-lowering drugs: are adverse effects predictable and reversible?
Topics: Aryl Hydrocarbon Hydroxylases; Bezafibrate; Cholesterol, LDL; Cytochrome P-450 Enzyme System; Digest | 2002 |
7 other studies available for gemfibrozil and Renal Insufficiency
| Article | Year |
|---|---|
Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Cisplatin; Creatinine; Disease Models, Animal | 2018 |
Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.
Topics: Acetanilides; Adolescent; Adrenergic beta-3 Receptor Agonists; Adult; Aged; Aging; Butyrylcholineste | 2019 |
Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Catalase; Coenzymes; Creatinine; Female; Gemfibrozil; Gl | 2005 |
The effects of gemfibrozil upon the hypercoagulable state in dyslipidaemic patients with chronic renal failure.
Topics: Adult; Blood Coagulation; Cholesterol, HDL; Chronic Disease; Cytokines; Female; Gemfibrozil; Humans; | 1996 |
Rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy.
Topics: Aged; Drug Interactions; Drug Therapy, Combination; Female; Gemfibrozil; Humans; Hydroxymethylglutar | 1999 |
A case with severe rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy--a case report.
Topics: Diabetes Mellitus; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Fatal Outcome; | 2000 |
Possible mechanisms of the fibrate-induced increase in serum creatinine.
Topics: Creatinine; Gemfibrozil; Humans; Hypolipidemic Agents; Renal Insufficiency; Urea | 2002 |