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gemfibrozil and Muscle Disorders

gemfibrozil has been researched along with Muscle Disorders in 16 studies

Research Excerpts

ExcerptRelevanceReference
" We describe a case of severe myopathy and rhabdomyolysis associated with concomitant use of simvastatin and gemfibrozil."7.69Rhabdomyolysis associated with simvastatin-gemfibrozil therapy. ( Isley, W; Rajeshawari, M; Tal, A, 1997)
"The Food and Drug Administration documents the receipt of 12 case reports of severe myopathy or rhabdomyolysis associated with concomitant use of lovastatin and gemfibrozil, including 10 voluntary postmarketing, and 2 required, reports."7.68Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. ( Gross, TP; Pierce, LR; Wysowski, DK, 1990)
" We describe a case of severe myopathy and rhabdomyolysis associated with concomitant use of simvastatin and gemfibrozil."3.69Rhabdomyolysis associated with simvastatin-gemfibrozil therapy. ( Isley, W; Rajeshawari, M; Tal, A, 1997)
"The Food and Drug Administration documents the receipt of 12 case reports of severe myopathy or rhabdomyolysis associated with concomitant use of lovastatin and gemfibrozil, including 10 voluntary postmarketing, and 2 required, reports."3.68Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. ( Gross, TP; Pierce, LR; Wysowski, DK, 1990)
" Regardless of the fibric acid derivative chosen, an empiric dosage reduction of 20% and close INR monitoring are warranted in patients receiving warfarin."2.45Interaction between gemfibrozil and warfarin: case report and review of the literature. ( Dixon, DL; Williams, VG, 2009)
" The long term administration of statin and fibrate to patients with primary and secondary hyperlipidemia was considered safe on the basis of our experience and literature data."2.42[Antilipemic therapy and rhabdomyolysis]. ( Balogh, Z; Paragh, G; Romics, L, 2003)
" We reviewed gemfibrozil- and fenofibrate-associated adverse event reports (AERs) submitted to the US Food and Drug Administration over a 5-year period."1.35Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use. ( Alsheikh-Ali, AA; Holoshitz, N; Karas, RH, 2008)
"A 61-year-old woman with hyperlipidemia was treated with gemfibrozil."1.29[Gemfibrozil-induced myopathy]. ( Adler, Y; Aron, A; Weiss, P, 1993)
"Lovastatin has been used with increasing frequency over the past few years to reduce serum cholesterol."1.28Lovastatin/gemfibrozil myopathy: a clinical, histochemical, and ultrastructural study. ( Chucrallah, A; De Girolami, U; Federman, M; Freeman, R, 1992)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (62.50)18.2507
2000's5 (31.25)29.6817
2010's0 (0.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Zabihi, M1
Askarian, F1
Hekmatimoghaddam, S1
Zabihi, MS1
Vahidi, F1
Dixon, DL1
Williams, VG1
Paragh, G1
Balogh, Z1
Romics, L1
Holoshitz, N1
Alsheikh-Ali, AA1
Karas, RH1
Tobert, JA2
Aron, A1
Adler, Y1
Weiss, P1
Rosenson, RS1
Tal, A1
Rajeshawari, M1
Isley, W1
Weismantel, D1
Danis, P1
Chucrallah, A1
De Girolami, U1
Freeman, R1
Federman, M1
Magarian, GJ1
Lucas, LM1
Colley, C1
London, SF1
Gross, KF1
Ringel, SP1
Pierce, LR1
Wysowski, DK1
Gross, TP1

Reviews

4 reviews available for gemfibrozil and Muscle Disorders

ArticleYear
Interaction between gemfibrozil and warfarin: case report and review of the literature.
    Pharmacotherapy, 2009, Volume: 29, Issue:6

    Topics: Anticoagulants; Atrial Fibrillation; Drug Interactions; Follow-Up Studies; Gemfibrozil; Humans; Hypo

2009
[Antilipemic therapy and rhabdomyolysis].
    Orvosi hetilap, 2003, Mar-16, Volume: 144, Issue:11

    Topics: Anticholesteremic Agents; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Gemfibrozil; Hu

2003
Clinical inquiries. What laboratory monitoring is appropriate to detect adverse drug reactions in patients on cholesterol-lowering agents?
    The Journal of family practice, 2001, Volume: 50, Issue:11

    Topics: Anticholesteremic Agents; Dose-Response Relationship, Drug; Drug Monitoring; Evidence-Based Medicine

2001
Gemfibrozil-induced myopathy.
    Archives of internal medicine, 1991, Volume: 151, Issue:9

    Topics: Clofibrate; Drug Therapy, Combination; Gemfibrozil; Humans; Hypertriglyceridemia; Lovastatin; Male;

1991

Other Studies

12 other studies available for gemfibrozil and Muscle Disorders

ArticleYear
Combination of atorvastatin and gemfibrozil plus physical activity: an animal model of statin/fibrate-induced myopathy.
    Somatosensory & motor research, 2021, Volume: 38, Issue:1

    Topics: Animals; Atorvastatin; Disease Models, Animal; Fibric Acids; Gemfibrozil; Hydroxymethylglutaryl-CoA

2021
Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use.
    The American journal of cardiology, 2008, Jan-01, Volume: 101, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Databases, Factual;

2008
HMG-CoA reductase inhibitors, gemfibrozil, and myopathy.
    The American journal of cardiology, 1995, Apr-15, Volume: 75, Issue:12

    Topics: Drug Combinations; Drug Interactions; Follow-Up Studies; Gemfibrozil; Humans; Lovastatin; Muscular D

1995
Lovastatin and myopathy.
    The American journal of medicine, 1994, Volume: 96, Issue:3

    Topics: Drug Synergism; Gemfibrozil; Humans; Lovastatin; Muscular Diseases; Pravastatin

1994
[Gemfibrozil-induced myopathy].
    Harefuah, 1993, Nov-01, Volume: 125, Issue:9

    Topics: Diabetes Complications; Female; Gemfibrozil; Humans; Hyperlipidemias; Kidney Failure, Chronic; Middl

1993
Gemfibrozil-lovastatin-associated myalgia.
    The American journal of cardiology, 1993, Feb-15, Volume: 71, Issue:5

    Topics: Drug Therapy, Combination; Gemfibrozil; Humans; Lovastatin; Muscular Diseases

1993
Rhabdomyolysis associated with simvastatin-gemfibrozil therapy.
    Southern medical journal, 1997, Volume: 90, Issue:5

    Topics: Anticholesteremic Agents; Drug Therapy, Combination; Female; Gemfibrozil; Humans; Hyperlipidemias; H

1997
Choice of lipid-regulating drugs.
    The Medical letter on drugs and therapeutics, 2001, May-28, Volume: 43, Issue:1105

    Topics: Apolipoproteins; Arteriosclerosis; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Drug Intera

2001
Lovastatin/gemfibrozil myopathy: a clinical, histochemical, and ultrastructural study.
    European neurology, 1992, Volume: 32, Issue:5

    Topics: Drug Therapy, Combination; Female; Gemfibrozil; Humans; Lovastatin; Microscopy, Electron; Middle Age

1992
Cholesterol-lowering agent myopathy (CLAM).
    Neurology, 1991, Volume: 41, Issue:7

    Topics: Aged; Anticholesteremic Agents; Female; Gemfibrozil; Humans; Lovastatin; Muscular Diseases

1991
Myopathy and rhabdomyolysis with lovastatin taken with gemfibrozil.
    JAMA, 1990, Dec-19, Volume: 264, Issue:23

    Topics: Adolescent; Creatine Kinase; Drug Synergism; Drug Therapy, Combination; Gemfibrozil; Humans; Isoenzy

1990
Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy.
    JAMA, 1990, Jul-04, Volume: 264, Issue:1

    Topics: Acute Kidney Injury; Adult; Aged; Creatine Kinase; Drug Interactions; Drug Therapy, Combination; Fem

1990