gemfibrozil has been researched along with Hypertension in 17 studies
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether lowering of plasma triglyceride concentrations using the fibrate peroxisome proliferator-activated receptor (PPAR)alpha agonist gemfibrozil would influence insulin sensitivity to various aspects of intermediary metabolism among subjects with type 2 diabetes mellitus." | 9.10 | Effects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia. ( Nattrass, M; Smith, JM; Whitelaw, DC, 2002) |
| "This study investigated the possible synergistic role of obesity in hypertension-induced cardiac remodeling and its modulation by gemfibrozil treatment in rats." | 7.77 | Impact of obesity on hypertension-induced cardiac remodeling: role of oxidative stress and its modulation by gemfibrozil treatment in rats. ( Krishan, P; Singh, AP; Singh, M; Singh, R, 2011) |
| "To report a case of rhabdomyolysis and acute renal failure associated with gemfibrozil monotherapy of hyperlipidemia." | 7.72 | Rhabdomyolysis and renal failure associated with gemfibrozil monotherapy. ( Layne, RD; Sehbai, AS; Stark, LJ, 2004) |
| "Treatment with simvastatin or gemfibrozil in hypertensive patients in hydrochlorothiazide monotherapy can reduce total cholesterol and LDL-cholesterol plasma levels, while significantly increasing HDL plasma levels compared to placebo." | 6.67 | [Simvastatin versus gemfibrozil in the treatment of primary hypercholesterolemia in hypertensive patients treated with hydrochlorothiazide]. ( Bentivoglio, M; Berioli, S; Conti, R; Corea, L; Osanna, RA; Savino, K; Zollino, L, 1990) |
| "To examine whether lowering of plasma triglyceride concentrations using the fibrate peroxisome proliferator-activated receptor (PPAR)alpha agonist gemfibrozil would influence insulin sensitivity to various aspects of intermediary metabolism among subjects with type 2 diabetes mellitus." | 5.10 | Effects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia. ( Nattrass, M; Smith, JM; Whitelaw, DC, 2002) |
| "This study investigated the possible synergistic role of obesity in hypertension-induced cardiac remodeling and its modulation by gemfibrozil treatment in rats." | 3.77 | Impact of obesity on hypertension-induced cardiac remodeling: role of oxidative stress and its modulation by gemfibrozil treatment in rats. ( Krishan, P; Singh, AP; Singh, M; Singh, R, 2011) |
| "To report a case of rhabdomyolysis and acute renal failure associated with gemfibrozil monotherapy of hyperlipidemia." | 3.72 | Rhabdomyolysis and renal failure associated with gemfibrozil monotherapy. ( Layne, RD; Sehbai, AS; Stark, LJ, 2004) |
| " The three groups were similar for age, sex and geographical region, but significantly more patients on bezafibrate had diabetes and/or hypertension than those on gemfibrozil or simvastatin." | 3.70 | A comparison of the use, effectiveness and safety of bezafibrate, gemfibrozil and simvastatin in normal clinical practice using the New Zealand Intensive Medicines Monitoring Programme (IMMP). ( Beggs, PW; Clark, DW; Coulter, DM; Williams, SM, 1999) |
| "Gemfibrozil treatment was associated with 3% to 6% decreases in the small, lipid-poor prebeta-1 HDL and in the large, lipid-rich alpha-1 and alpha-2 HDL and with increases in the small alpha-3 (3%) and prealpha-3 (16%) HDLs." | 2.73 | Relation of gemfibrozil treatment and high-density lipoprotein subpopulation profile with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial. ( Asztalos, BF; Bloomfield, HE; Collins, D; Horvath, KV; Robins, SJ; Schaefer, EJ, 2008) |
| "Treatment with simvastatin or gemfibrozil in hypertensive patients in hydrochlorothiazide monotherapy can reduce total cholesterol and LDL-cholesterol plasma levels, while significantly increasing HDL plasma levels compared to placebo." | 2.67 | [Simvastatin versus gemfibrozil in the treatment of primary hypercholesterolemia in hypertensive patients treated with hydrochlorothiazide]. ( Bentivoglio, M; Berioli, S; Conti, R; Corea, L; Osanna, RA; Savino, K; Zollino, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, R | 1 |
| Singh, AP | 1 |
| Singh, M | 1 |
| Krishan, P | 1 |
| Kervinen, H | 1 |
| Huittinen, T | 1 |
| Vaarala, O | 1 |
| Leinonen, M | 1 |
| Saikku, P | 1 |
| Manninen, V | 2 |
| Mänttäri, M | 2 |
| Layne, RD | 1 |
| Sehbai, AS | 1 |
| Stark, LJ | 1 |
| Borghi, C | 1 |
| Dormi, A | 1 |
| Veronesi, M | 1 |
| Sangiorgi, Z | 1 |
| Gaddi, A | 1 |
| Sigal, R | 2 |
| Malcolm, J | 2 |
| Meggison, H | 1 |
| Arnaout, A | 1 |
| Guzik, TJ | 1 |
| Harrison, DG | 1 |
| Asztalos, BF | 1 |
| Collins, D | 1 |
| Horvath, KV | 1 |
| Bloomfield, HE | 1 |
| Robins, SJ | 1 |
| Schaefer, EJ | 1 |
| Virkkunen, H | 1 |
| Härmä, M | 1 |
| Kauppinen, T | 1 |
| Tenkanen, L | 1 |
| Tiula, E | 1 |
| Alikoski, T | 1 |
| Van Buren, CT | 1 |
| Górriz, JL | 1 |
| Sancho, A | 1 |
| Lopez-Martin, JM | 1 |
| Alcoy, E | 1 |
| Catalán, C | 1 |
| Pallardó, LM | 1 |
| Andrews, TC | 1 |
| Whitney, EJ | 1 |
| Green, G | 1 |
| Kalenian, R | 1 |
| Personius, BE | 1 |
| Beggs, PW | 1 |
| Clark, DW | 1 |
| Williams, SM | 1 |
| Coulter, DM | 1 |
| Whitelaw, DC | 1 |
| Smith, JM | 1 |
| Nattrass, M | 1 |
| Berioli, S | 1 |
| Bentivoglio, M | 1 |
| Conti, R | 1 |
| Osanna, RA | 1 |
| Savino, K | 1 |
| Zollino, L | 1 |
| Corea, L | 1 |
| Oliver, MF | 1 |
2 reviews available for gemfibrozil and Hypertension
| Article | Year |
|---|---|
Prevention of cardiovascular events in diabetes.
Topics: Angioplasty, Balloon; Antihypertensive Agents; Aspirin; Bezafibrate; Cardiovascular Diseases; Corona | 2004 |
Prevention of cardiovascular events in diabetes.
Topics: Angioplasty, Balloon; Antihypertensive Agents; Aspirin; Bezafibrate; Cardiovascular Diseases; Clopid | 2006 |
7 trials available for gemfibrozil and Hypertension
| Article | Year |
|---|---|
Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticholesteremic Agents; Antihype | 2004 |
Relation of gemfibrozil treatment and high-density lipoprotein subpopulation profile with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial.
Topics: Cardiovascular Diseases; Coronary Disease; Gemfibrozil; Humans; Hypertension; Hypolipidemic Agents; | 2008 |
Effects of hypertension and dyslipidemia on the decline in renal function.
Topics: Adult; Blood Pressure; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Coronary Disease; Creatin | 1995 |
Effect of gemfibrozil +/- niacin +/- cholestyramine on endothelial function in patients with serum low-density lipoprotein cholesterol levels <160 mg/dl and high-density lipoprotein cholesterol levels <40 mg/dl.
Topics: Aged; Brachial Artery; Cholestyramine Resin; Coronary Disease; Double-Blind Method; Drug Therapy, Co | 1997 |
Effects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia.
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Diet, Diabetic; Double-Blind | 2002 |
[Simvastatin versus gemfibrozil in the treatment of primary hypercholesterolemia in hypertensive patients treated with hydrochlorothiazide].
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Female; Gemfibrozil; Humans; Hydrochlorothiazide | 1990 |
Strategy, yield and risks of controlling plasma lipids in the primary prevention of coronary heart disease.
Topics: Adult; Arteriosclerosis; Cholesterol; Clinical Trials as Topic; Clofibrate; Coronary Disease; Diet; | 1985 |
8 other studies available for gemfibrozil and Hypertension
| Article | Year |
|---|---|
Impact of obesity on hypertension-induced cardiac remodeling: role of oxidative stress and its modulation by gemfibrozil treatment in rats.
Topics: Animals; Aorta, Abdominal; Blood Pressure; Cardiomegaly; Dietary Fats; Gemfibrozil; Glutathione; Hea | 2011 |
Antibodies to human heat shock protein 60, hypertension and dyslipidemia. A study of joint effects on coronary risk.
Topics: Antibodies; Chaperonin 60; Coronary Disease; Gemfibrozil; Humans; Hyperlipidemias; Hypertension; Hyp | 2003 |
Rhabdomyolysis and renal failure associated with gemfibrozil monotherapy.
Topics: Acute Kidney Injury; Adult; Creatinine; Diabetes Mellitus, Type 1; Gemfibrozil; Humans; Hyperlipidem | 2004 |
Endothelial NF-kappaB as a mediator of kidney damage: the missing link between systemic vascular and renal disease?
Topics: Albuminuria; Angiotensin II; Animals; Atherosclerosis; Endothelium, Vascular; Fibrosis; Gemfibrozil; | 2007 |
Shift work, occupational noise and physical workload with ensuing development of blood pressure and their joint effect on the risk of coronary heart disease.
Topics: Adult; Blood Pressure; Coronary Disease; Follow-Up Studies; Gemfibrozil; Humans; Hypertension; Hypol | 2007 |
Hyperlipidemia and hypertension: impact of steroid withdrawal.
Topics: Adrenal Cortex Hormones; Cholestyramine Resin; Female; Gemfibrozil; Heart Transplantation; Humans; H | 1993 |
Rhabdomyolysis and acute renal failure associated with gemfibrozil therapy.
Topics: Acute Kidney Injury; Aged; Angiotensin-Converting Enzyme Inhibitors; Bicarbonates; Diabetes Mellitus | 1996 |
A comparison of the use, effectiveness and safety of bezafibrate, gemfibrozil and simvastatin in normal clinical practice using the New Zealand Intensive Medicines Monitoring Programme (IMMP).
Topics: Bezafibrate; Cohort Studies; Comorbidity; Diabetes Complications; Female; Gemfibrozil; Humans; Hyper | 1999 |