Page last updated: 2024-08-24

gemcitabine and Liver Dysfunction

gemcitabine has been researched along with Liver Dysfunction in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (38.46)29.6817
2010's7 (53.85)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Arima, F1
Bergeat, D; Coulouarn, C; De La Torre, C; Dooley, S; Ebert, MPA; Gretz, N; Li, J; Liebe, R; Lin, T; Sulpice, L; Weng, HL; Yuan, X1
Endo, I; Hata, M; Homma, Y; Ito, E; Kaizu, H; Koike, I; Kumamoto, T; Matsuyama, R; Mukai, Y; Sato, M; Sawada, Y; Sugiura, M; Takano, S; Yabushita, Y1
Beijnen, JH; Cerny, T; Gillessen, S; Hitz, F; Huitema, AD; Joerger, M; Koeberle, D; Rosing, H; Schellens, JH1
Abali, H; Köse, F; Mertsoylu, H; Muallaoğlu, S; Ozyilkan, O; Sezer, A; Sümbül, AT1
Ando, Y; Ebata, T; Fujita, K; Maeda, O; Mitsuma, A; Nagino, M; Sasaki, Y; Shibata, T; Shimokata, T1
Citro, G; Cognetti, F; Colantonio, S; Contestabile, M; Di Segni, S; Felici, A; Milella, M; Nuvoli, B; Sacconi, A; Sperduti, I; Zaratti, M1
Endo, S; Hashimoto, K; Iguchi, C; Itakura, M; Koike, M; Nio, Y; Nishi, T; Omori, H; Sato, Y; Takamura, M; Takeda, H1
Hall, PD; Teusink, AC1
Aspillaga M, A; Buttinghausen, V; Chandía C, M; Orellana, M1
Curran, MP; Plosker, GL1
Eklund, JW; Mulcahy, MF; Trifilio, S1
Budman, D; Byrd, J; Egorin, MJ; Hawkins, M; Hohl, R; Hollis, D; Mani, S; Meropol, NJ; Ratain, MJ; Rosner, GL; Venook, AP1

Reviews

2 review(s) available for gemcitabine and Liver Dysfunction

ArticleYear
Vinorelbine: a review of its use in elderly patients with advanced non-small cell lung cancer.
    Drugs & aging, 2002, Volume: 19, Issue:9

    Topics: Age Factors; Aged; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Injections, Intravenous; Liver Diseases; Lung Neoplasms; Vinblastine; Vinorelbine

2002
Chemotherapy dosing in the setting of liver dysfunction.
    Oncology (Williston Park, N.Y.), 2005, Volume: 19, Issue:8

    Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Gemcitabine; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Maximum Tolerated Dose; Neoplasms; Randomized Controlled Trials as Topic; Risk Assessment; Topotecan

2005

Trials

2 trial(s) available for gemcitabine and Liver Dysfunction

ArticleYear
Optimal dose of gemcitabine for the treatment of biliary tract or pancreatic cancer in patients with liver dysfunction.
    Cancer science, 2016, Volume: 107, Issue:2

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biliary Tract Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Female; Gemcitabine; Humans; Liver; Liver Diseases; Male; Middle Aged; Pancreatic Neoplasms

2016
Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and Leukemia Group B 9565.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:14

    Topics: Aged; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Bilirubin; Creatinine; Deoxycytidine; Female; Gemcitabine; Humans; Liver Diseases; Liver Function Tests; Male; Middle Aged; Models, Biological; Neoplasms; Renal Insufficiency

2000

Other Studies

9 other study(ies) available for gemcitabine and Liver Dysfunction

ArticleYear
[A Case of Non-Hodgkin Lymphoma with Liver Involvement and Severe Jaundice That Benefited from Therapy with Gemcitabine, Carboplatin, Dexamethasone(GCD)Therapy with Rituximab].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2023, Volume: 50, Issue:11

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Dexamethasone; Doxorubicin; Gemcitabine; Humans; Hyperbilirubinemia; Jaundice; Liver Diseases; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Rituximab; Treatment Outcome; Vincristine

2023
SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance.
    British journal of cancer, 2018, Volume: 119, Issue:11

    Topics: Antineoplastic Agents; Bile Duct Neoplasms; Biomarkers, Tumor; Cell Proliferation; Cholangiocarcinoma; Chronic Disease; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Liver Diseases; SOX9 Transcription Factor; Survival Analysis; Treatment Outcome

2018
Outcome of postoperative radiation therapy for cholangiocarcinoma and analysis of dose-volume histogram of remnant liver.
    Medicine, 2019, Volume: 98, Issue:31

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cholangiocarcinoma; Cisplatin; Combined Modality Therapy; Deoxycytidine; Drug Combinations; Gemcitabine; Hepatectomy; Humans; Kaplan-Meier Estimate; Liver Diseases; Liver Neoplasms; Middle Aged; Neoplasm Staging; Oxonic Acid; Pyridines; Radiation Injuries; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy, Adjuvant; Tegafur; Tomography, X-Ray Computed

2019
Safety and pharmacology of gemcitabine and capecitabine in patients with advanced pancreatico-biliary cancer and hepatic dysfunction.
    Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Humans; Hyperbilirubinemia; Liver Diseases; Male; Middle Aged; Pancreatic Neoplasms

2014
Gemcitabine + platinum combination chemotherapy in patients with metastatic cancer who suffer from severe and irreversible hepatic impairment: a single center experience.
    Hepato-gastroenterology, 2014, Volume: 61, Issue:135

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Deoxycytidine; Female; Gemcitabine; Humans; Liver Diseases; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Turkey

2014
Pharmacokinetics of gemcitabine at fixed-dose rate infusion in patients with normal and impaired hepatic function.
    Clinical pharmacokinetics, 2009, Volume: 48, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Biliary Tract Neoplasms; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Gemcitabine; Humans; Infusions, Intravenous; Liver Diseases; Liver Function Tests; Male; Middle Aged; Pancreatic Neoplasms; Prospective Studies; Tandem Mass Spectrometry

2009
Placement of an expandable metallic stent improves the efficacy of chemoradiotherapy for pancreatic cancer with malignant portal vein stenosis or obstruction.
    Anticancer research, 2009, Volume: 29, Issue:8

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Constriction, Pathologic; Cyclophosphamide; Deoxycytidine; Female; Gemcitabine; Humans; Hypertension, Portal; Liver Diseases; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pancreatic Neoplasms; Prognosis; Radiotherapy Dosage; Stents; Survival Rate; Tegafur; Treatment Outcome; Uracil

2009
Toxicities of gemcitabine in patients with severe hepatic dysfunction.
    The Annals of pharmacotherapy, 2010, Volume: 44, Issue:4

    Topics: Alanine Transaminase; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Bilirubin; Breast Neoplasms; Deoxycytidine; Female; Gemcitabine; Humans; Leukocyte Count; Liver Diseases; Male; Neoplasms; Pancreatic Neoplasms; Platelet Count; Retrospective Studies

2010
[Hodgkin lymphoma with hepatic involvement treated with dexametasone, gemcitabine and cisplatin as a bridge to standard therapy: report of one case].
    Revista medica de Chile, 2012, Volume: 140, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Dexamethasone; Female; Gemcitabine; Hodgkin Disease; Humans; Liver Diseases; Middle Aged; Salvage Therapy

2012