Page last updated: 2024-08-24

gemcitabine and Leukemia

gemcitabine has been researched along with Leukemia in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (34.38)	18.2507
2000's	16 (50.00)	29.6817
2010's	5 (15.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Campbell, DO; Czernin, J; Herschman, HR; Laing, RE; Phelps, ME; Radu, CG; Satyamurthy, N; Walter, MA; Witte, ON	1
Adema, AD; Kathmann, I; Losekoot, N; Myhren, F; Peters, GJ; Sandvold, ML; Smid, K	1
Bourgaux, C; Couvreur, P; Desmaële, D; Lepêtre-Mouelhi, S; Pili, B; Reddy, LH	1
Cass, CE; Damaraju, VL; Karpinski, E; Mowles, D; Nowak, I; Robins, MJ; Smith, KM; Young, JD	1
Adema, AD; Honeywell, RJ; Losekoot, N; Myhren, F; Peters, GJ; Sandvold, ML; Smid, K; Verheul, HM	1
Fritzer-Szekeres, M; Golakoti, T; Graser, G; Jaeger, W; Krupitza, G; Madlener, S; Saiko, P; Schwarz, S; Somepalli, V; Szekeres, T	1
Ames, MM; Avramis, VI; Krailo, MD; Liu-Mares, W; Reaman, GH; Reid, JM; Safgren, SL; Seibel, NL; Steinherz, PG	1
Bacher, N; Hohla, F; Konwalinka, G; Mühlmann, O; Strasser-Wozak, E; Tiefenthaler, M; Wein, W	1
Bresters, D; Broekhuizen, AJ; Faircloth, GT; Jimeno, J; Kaaijk, P; Kaspers, GJ	1
Kolb, EA; Steinherz, PG	1
Bergman, AM; Breistøl, K; Comijn, EM; Fodstad, O; Hendriks, HR; Kuiper, CM; Myhren, F; Noordhuis, P; Peters, GJ; Sandvold, ML; Smid, K; Voorn, DA	1
Bergman, AM; Hendriks, HR; Kuiper, CM; Myhren, F; Peters, GJ; Sandvold, ML	1
Dexheimer, TS; Fellows, IM; Gleason-Guzman, M; Hurley, LH; Schwaebe, M; Vankayalapati, H; Whitten, JP	1
Bodo, J; Duraj, J; Rauko, P; Sedlak, J; Sulikova, M	1
Couvreur, P; Desmaële, D; Dubernet, C; Marque, PE; Mouelhi, SL; Reddy, LH	1
Adams, DJ; Giles, F; Jacobsen, TF; Myhren, F; Rizzieri, DA; Sandvold, ML	1
Chapman, AJ; Chubb, S; Gandhi, V; Hertel, LW; Huang, P; Mineishi, S; Nowak, BJ; Plunkett, W; Yang, Y	1
Csoka, K; Larsson, R; Liliemark, J; Nygren, P	1
Hata, Y; Prajda, N; Weber, G	1
Wiley, JS	1
Huang, P; Iwasaki, H; Keating, MJ; Plunkett, W	1
Dent, P; Grant, S; Kramer, LB; Povirk, LF; Saunders, AM; Vrana, JA; Zhang, XF	1
Cvitkovic, E; Faivre, S; Raymond, E; Woynarowski, JM	1
Bergman, AM; Kroep, JR; Peters, GJ; Pinedo, HM; Ruiz van Haperen, VW; van Moorsel, CJ; Veerman, G; Voorn, DA	1
Cass, CE; Clarke, ML; Gourdeau, H; Jolivet, J; Lafrenière, RG; Lee, N; Mackey, JR; Mowles, D; Ouellet, F; Richard, A; Selner, M; Young, JD	1
Gandhi, V; Krett, N; Nabhan, C; Rosen, S	1
Adams, DJ; Bass, AJ; Davis, P; DeCastro, CM; Foster, T; Gockerman, JP; Hurwitz, H; Jacobson, R; Laughlin, MJ; Moore, JO; Petros, WP; Rizzieri, DA; Rosner, GL	1
Adams, DJ; Bass, AJ; Davis, P; DeCastro, CM; Foster, T; Gockerman, JP; Hammett, E; Moore, JO; Payne, N; Rizzieri, DA; Rosner, GL	1
Nakamura, T; Ueda, T	1
Du, M; Faucher, K; Grunewald, R; Kantarjian, H; Plunkett, W; Tarassoff, P	1
Abbruzzese, J; Grunewald, R; Kantarjian, H; Keating, MJ; Plunkett, W; Tarassoff, P	1
Gandhi, V; Plunkett, W	1

Reviews

2 review(s) available for gemcitabine and Leukemia

Article	Year
Role of differentiation induction in action of purine antimetabolites. Pharmacy world & science : PWS, 1994, Apr-15, Volume: 16, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Deoxycytidine; Gemcitabine; Humans; Leukemia; Oncogenes; Ribavirin	1994
Gemcitabine in hematologic malignancies. Current opinion in oncology, 2001, Volume: 13, Issue:6 Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Deoxycytidine; DNA; Gemcitabine; Hodgkin Disease; Humans; Leukemia; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Tumor Cells, Cultured	2001

Trials

5 trial(s) available for gemcitabine and Leukemia

Article	Year
Phase I study of gemcitabine (difluorodeoxycytidine) in children with relapsed or refractory leukemia (CCG-0955): a report from the Children's Cancer Group. Leukemia & lymphoma, 2002, Volume: 43, Issue:10 Topics: Adolescent; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Deoxycytidine; Female; Gemcitabine; Half-Life; Humans; Infant; Leukemia; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Salvage Therapy	2002
A new multidrug reinduction protocol with topotecan, vinorelbine, thiotepa, dexamethasone, and gemcitabine for relapsed or refractory acute leukemia. Leukemia, 2003, Volume: 17, Issue:10 Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Deoxycytidine; Dexamethasone; Drug Administration Schedule; Female; Gemcitabine; Humans; Leukemia; Male; Recurrence; Thiotepa; Topotecan; Treatment Outcome; Vinblastine; Vinorelbine	2003
Phase I evaluation of prolonged-infusion gemcitabine with mitoxantrone for relapsed or refractory acute leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Feb-01, Volume: 20, Issue:3 Topics: Acute Disease; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Gemcitabine; Humans; Infusions, Intravenous; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Mitoxantrone; Neural Tube Defects	2002
Phase I evaluation of prolonged-infusion gemcitabine with irinotecan for relapsed or refractory leukemia or lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jul-01, Volume: 20, Issue:13 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Camptothecin; Deoxycytidine; Drug Administration Schedule; Esophagitis; Evaluation Studies as Topic; Female; Gemcitabine; Humans; Infusions, Intravenous; Irinotecan; Leukemia; Lymphoma; Male; Middle Aged; Nausea; Neutropenia; Recurrence; Stomatitis; Treatment Outcome; Vomiting	2002
Gemcitabine in leukemia: a phase I clinical, plasma, and cellular pharmacology study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:3 Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Deoxycytidine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Evaluation; Gemcitabine; Humans; Leukemia; Middle Aged	1992

Other Studies

25 other study(ies) available for gemcitabine and Leukemia

Article	Year
Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America, 2009, Feb-24, Volume: 106, Issue:8 Topics: Animals; Antineoplastic Agents; Cytosine; Deoxycytidine; Gemcitabine; Humans; Leukemia; Mice; Positron-Emission Tomography	2009
Induction of resistance to the lipophilic cytarabine prodrug elacytarabine (CP-4055) in CEM leukemic cells. Nucleosides, nucleotides & nucleic acids, 2010, Volume: 29, Issue:4-6 Topics: Antineoplastic Agents; Cell Line, Tumor; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Nucleoside Deaminases; Polymerase Chain Reaction	2010
Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation. Nanoscale, 2010, Volume: 2, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Deoxycytidine; Gemcitabine; Leukemia; Liposomes; Mice; Particle Size; Polyethylene Glycols; Prodrugs; Scattering, Small Angle; Squalene; X-Ray Diffraction	2010
Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1. Biochemical pharmacology, 2011, Jan-01, Volume: 81, Issue:1 Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Cell Proliferation; Cytoprotection; Deoxycytidine; Dose-Response Relationship, Drug; Gemcitabine; Humans; Leukemia; Membrane Transport Proteins; Molecular Structure; Oocytes; Pyrimidine Nucleosides; Saccharomyces cerevisiae; Xenopus laevis	2011
Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126. Investigational new drugs, 2012, Volume: 30, Issue:5 Topics: Antineoplastic Agents; Cell Line; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Dipyridamole; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Nucleoside Transport Proteins; Nucleotidases	2012
Combination effects of digalloylresveratrol with arabinofuranosylcytosine and difluorodeoxycytidine in human leukemia and pancreatic cancer cells. Nucleosides, nucleotides & nucleic acids, 2011, Volume: 30, Issue:12 Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Cytarabine; Deoxycytidine; Gallic Acid; Gemcitabine; HL-60 Cells; Humans; Leukemia; Pancreatic Neoplasms; Stilbenes; Tumor Stem Cell Assay	2011
Delayed addition of deoxycytidine protects normal CD34+ cells against cytotoxicity of gemcitabine without compromising its activity against human leukemic cells. Stem cells (Dayton, Ohio), 2003, Volume: 21, Issue:3 Topics: Antigens, CD34; Antineoplastic Agents; Bone Marrow Cells; Cell Division; Coculture Techniques; Cytotoxins; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Resistance, Neoplasm; Drug Therapy, Combination; Gemcitabine; Hematopoietic Stem Cells; HL-60 Cells; Humans; Immunosuppressive Agents; Leukemia; T-Lymphocytes	2003
In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: a rational basis for clinical development. Leukemia, 2003, Volume: 17, Issue:7 Topics: Antineoplastic Agents; Blood Cells; Bone Marrow; Carnitine; Case-Control Studies; Cell Survival; Child; Deoxycytidine; Depsipeptides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Peptides, Cyclic; Podophyllotoxin	2003
Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Animals; Antimetabolites, Antineoplastic; Carbon; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cytidine Deaminase; Deoxycytidine; DNA; DNA Damage; Fatty Acids; Gemcitabine; Humans; Inhibitory Concentration 50; Leukemia; Melanoma; Mice; Mice, Nude; Models, Chemical; Neoplasm Transplantation; Nucleoside Deaminases; Phosphorylation; Rats; Time Factors	2004
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fatty Acids; Gemcitabine; Humans; Inhibitory Concentration 50; Leukemia; Mice; Neoplasms; Rats; Time Factors	2004
Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity. Molecular cancer therapeutics, 2005, Volume: 4, Issue:11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line; Cell Line, Tumor; Deoxycytidine; DNA; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Epoxy Compounds; Gemcitabine; In Vitro Techniques; Inhibitory Concentration 50; Leukemia; Lymphoma; Mice; Mice, Nude; Models, Chemical; Models, Molecular; Pancreatic Neoplasms; Stereoisomerism; Time Factors; Xanthones	2005
Diverse resveratrol sensitization to apoptosis induced by anticancer drugs in sensitive and resistant leukemia cells. Neoplasma, 2006, Volume: 53, Issue:5 Topics: Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Busulfan; Cell Cycle; Cell Line, Tumor; Cycloheximide; Deoxycytidine; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gemcitabine; Humans; Leukemia; Paclitaxel; Resveratrol; Stilbenes	2006
Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:2 Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; Drug Evaluation, Preclinical; Gemcitabine; Leukemia; Mice; Mice, Inbred DBA; Nanomedicine; Nanostructures; Squalene; Treatment Outcome	2008
Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Leukemia & lymphoma, 2008, Volume: 49, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cytarabine; Deoxycytidine; Drug Interactions; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Hydrazines; Idarubicin; Irinotecan; Leukemia; Lymphoma; Sulfonamides; Topotecan	2008
Difluorodeoxyguanosine: cytotoxicity, metabolism, and actions on DNA synthesis in human leukemia cells. Seminars in oncology, 1995, Volume: 22, Issue:4 Suppl 11 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinonucleosides; Base Sequence; Cricetinae; Deoxycytidine; Deoxyguanosine; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Gemcitabine; Humans; Leukemia; Molecular Sequence Data; Nucleotides; Peptide Chain Elongation, Translational; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); RNA, Neoplasm; Structure-Activity Relationship; Tumor Cells, Cultured	1995
Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors. Seminars in oncology, 1995, Volume: 22, Issue:4 Suppl 11 Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Cisplatin; Cladribine; Colorectal Neoplasms; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Gemcitabine; Humans; In Vitro Techniques; Leukemia; Lung Neoplasms; Lymphoma; Ribonucleotide Reductases; Tumor Cells, Cultured; Urogenital Neoplasms	1995
Seeking the nucleoside transporter. Nature medicine, 1997, Volume: 3, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Carrier Proteins; Cell Membrane; Cladribine; Cloning, Molecular; Cytarabine; Deoxycytidine; Erythrocytes; Gemcitabine; Glucose Transporter Type 1; Humans; Leukemia; Lymphoma; Membrane Proteins; Monosaccharide Transport Proteins; Nucleosides; Oocytes; Recombinant Proteins; Uridine; Vidarabine; Xenopus	1997
Differential incorporation of ara-C, gemcitabine, and fludarabine into replicating and repairing DNA in proliferating human leukemia cells. Blood, 1997, Jul-01, Volume: 90, Issue:1 Topics: Antineoplastic Agents; Binding Sites; Cytarabine; Deoxycytidine; DNA Repair; DNA Replication; DNA, Neoplasm; Gemcitabine; Humans; Leukemia; Tumor Cells, Cultured; Vidarabine	1997
Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation. Biochemical pharmacology, 1999, Jul-01, Volume: 58, Issue:1 Topics: Antimetabolites, Antineoplastic; Apoptosis; Bryostatins; Cell Cycle Proteins; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytarabine; Deoxycytidine; Drug Interactions; Enzyme Activation; Gemcitabine; Humans; Lactones; Leukemia; Macrolides; Microtubule-Associated Proteins; Mitogens; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins; U937 Cells	1999
Supraadditive effect of 2',2'-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines. Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxycytidine; DNA; Gemcitabine; Humans; Leukemia; Organoplatinum Compounds; Oxaliplatin; Tumor Cells, Cultured	1999
Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines. Biochimica et biophysica acta, 2000, Mar-06, Volume: 1474, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Leukemia; Lung Neoplasms; Mice; Ovarian Neoplasms; Rats; Ribonucleotide Reductases; Ribonucleotides; Tumor Cells, Cultured	2000
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. Cancer research, 2001, Oct-01, Volume: 61, Issue:19 Topics: Amino Acid Sequence; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cytarabine; Cytidine Deaminase; Cytosine; Deoxycytidine; Deoxycytidine Kinase; Dioxolanes; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Male; Membrane Proteins; Molecular Sequence Data; Nucleoside Transport Proteins; Phosphorylation; Prostatic Neoplasms; Sequence Homology, Amino Acid; Sodium; Stereoisomerism; Tritium; Tumor Cells, Cultured; Uridine	2001
[Clinical application of enzyme inhibitors--hematologic malignancies]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:9 Topics: Cytarabine; Deoxycytidine; DNA Topoisomerases, Type I; Etoposide; Gemcitabine; Humans; Leukemia; Mercaptopurine; Methotrexate; Purines; Pyrimidines; Thioguanine; Topoisomerase I Inhibitors	1991
Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia. Cancer research, 1990, Nov-01, Volume: 50, Issue:21 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Cytidine Triphosphate; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Leukemia; Male; Middle Aged; Neoplastic Cells, Circulating	1990
Modulatory activity of 2',2'-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer research, 1990, Jun-15, Volume: 50, Issue:12 Topics: Arabinonucleosides; Arabinonucleotides; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Leukemia; Phosphorylation; Tumor Cells, Cultured; Vidarabine	1990