Page last updated: 2024-08-24

gemcitabine and Head and Neck Neoplasms

gemcitabine has been researched along with Head and Neck Neoplasms in 85 studies

Research

Studies (85)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (17.65)18.2507
2000's43 (50.59)29.6817
2010's24 (28.24)24.3611
2020's3 (3.53)2.80

Authors

AuthorsStudies
Chang, WC; Chiu, CF; Hsieh, CY; Hua, CH; Lien, MY; Lin, CC; Lin, CY; Lo, WJ1
Feng, W; Hong, H; Huang, X; Jiang, W; Li, Z; Liang, J; Liang, L; Liu, Q; Liu, Y; Liu, ZG; Peng, Y; Xian, S; Yang, S; Zhang, Y; Zhang, Z; Zhong, G; Zhou, Y1
Hayashi, R; Hayashi, T; Katada, A; Kishibe, K; Kobayashi, H; Komatsuda, H; Kono, M; Kosaka, A; Kumai, T; Nagato, T; Ohara, K; Ohkuri, T; Sato, R; Takahara, M; Wakisaka, R; Yamaki, H1
Bartscht, T; Hakim, SG; Idel, C; Rades, D1
Clark, JI; Kucuk, O; Malhotra, B; Moon, J; Urba, SG; Wolf, GT; Worden, FP1
Chen, YW; Chou, KM; Chu, P; Liu, X; Loria, S; Wang, Y; Yen, Y; Zhou, W1
Fujisawa, T; Han, J; Husain, SR; Puri, RK1
Chen, EY; Eastman, A; Hodge, S; Hou, H; Khan, N; Kuppusamy, M; Kuppusamy, P; Swartz, HM1
Cui, L; Ji, SL; Xiong, L; Zhang, CY; Zheng, HL; Zhu, MH1
Benasso, M; Merlano, MC; Peeters, M; Specenier, P; Szturz, P; Van den Weyngaert, D; Van Gestel, D; Van Laer, C; Vanderveken, OM; Vermorken, J; Wouters, K1
Chang, CL; Chen, JH; Chen, TM; Lai, MT; Lee, FP; Lin, KC; Wu, CC; Wu, SY; Yen, YC; Yuan, KS1
Akita, H; Hokari, M; Iwasaki, Y; Kamoshima, Y; Sawamura, Y1
Awada, A; Bernier, J; Bogaerts, J; Buter, J; de Mulder, P; Lacombe, D; Licitra, L; Locati, LD; Thomas, J; van Herpen, CM; Vermorken, JB1
Chauhan, A; Manocha, KK; Sharma, T; Singh, H1
Chang, PM; Chang, SY; Chen, PM; Chu, PY; Huang, JL; Tai, SK; Tsai, TL; Tzeng, CH; Wang, HM; Wang, YF; Yang, MH1
Altintas, S; Huizing, MT; Specenier, PM; Van den Brande, J; Van den Weyngaert, D; Van Laer, C; Vermorken, JB; Weyler, J1
Baay, M; Lambrechts, HA; Lardon, F; Meijnders, P; Pattyn, GG; Pauwels, B; Vermorken, JB; Wouters, A1
Aelbrecht, K; De Boeck, G; Dyck, J; Guetens, G; Specenier, P; Van den Weyngaert, D; Vermorken, JB; Weyler, J1
Carlson, D; Fury, MG; Haque, S; Pfister, D; Shen, R; Stambuk, H1
Carron, MA; Kucuk, O; Lin, HS; Shkoukani, MA; Tulunay, O1
Sun, Q; Yu, J; Zhang, L; Zheng, X1
Abo-Elyazeed, A; El-Hadaad, HA; Halim, AA; Wahba, HA1
Aguilar Ponce, JL; Cabrera Aquino, G; Chilaca Rosas, MF; Frías Mendivil, M; Granados García, M; Lavín Lozano, AJ; Maldonado Magos, F; Montes Luis, MM; Olvera Caraza, D; Segura Pacheco, BA1
Beniwal, P; Blair, EA; Cohen, EEW; Dekker, AJ; Gomez-Abuin, G; Haraf, D; Kocherginsky, M; Langerman, A; Portugal, L; Salama, JK; Seiwert, T; Stenson, KM; Villaflor, VM; Vokes, EE; Williams, RD; Witt, ME1
Afonso, SL; da Silva, LG; Stefano, EJ; Tavares, VC; Viani, GA1
Afrin, LB; Bielawski, J; Bostick, R; Chaudhary, U; Day, TA; Garrett-Mayer, E; Gillespie, MB; Hannun, YA; O'Brien, PE; Ogretmen, B; Saddoughi, SA; Senkal, CE; Sharma, AK; Shirai, K; Simon, GR; Wilhoit, CS1
Abdelraheem, AG; Ali, EM1
Colantonio, I; Comino, A; Crook, T; Denaro, N; Gasco, M; Lattanzio, L; Lo Nigro, C; Merlano, M; Monteverde, M; Natoli, G; Russi, E; Syed, N; Vivenza, D1
El Deen, DA; El Morsy, SM; Toson, EA1
Chen, XQ; Li, YJ; Wang, KF; Wang, L; Wang, ZH; Xia, YF; Xia, ZJ1
Aguilar-Ponce, JL; Alvarez-Avitia, MA; Arrieta, O; Castillo-Hernández, C; Cruz López, JC; De la Garza-Salazar, J; González-Ramírez, I; Granados-García, M; Lara-Cruz, G; Maldonado-Magos, F; Martinez-Juárez, I; Medina-Santillan, R1
Needle, MN1
Ameye, G; Cedervall, B; Grégoire, V; Libouton, JM; Michaux, L; Octave-Prignot, M; Rosier, JF; Scalliet, P; Verellen-Dumoulin, C1
Aguilar-Ponce, J; Alvarado, A; Castillo-Henkel, C; De la Garza, J; Dueñas-González, A; Granados-García, M; Green, D; Herrera-Gómez, A; Luna-Ortiz, K; Martínez-Said, H; Poitevin-Chacón, A; Segura-Pacheco, B; Villavicencio, V1
Benasso, M; Corvò, R; Pallestrini, E; Ponzanelli, A; Ricci, I; Rosso, R; Sanguineti, G; Santelli, A; Vitale, V1
Beauduin, M; Bruniaux, M; Grégoire, V; Husson, B; Octave-Prignot, M; Rosier, JF1
Argiris, A; Eng, C; Haraf, DJ; Kozloff, MF; Milano, MT; Mittal, BB; Pelzer, H; Stenson, KM; Vokes, EE; Witt, ME1
Airoldi, M; Cagliero, E; Cattel, L; Goffredo, F; Passera, R; Stella, B1
Balm, AJ; Damen, E; Eisbruch, A; Marsh, R; Pameijer, FA; Rasch, C; Schwartz, M; Van As, CJ; Vineberg, K1
Argiris, A; Haraf, DJ; Kao, J; Milano, MT; Mittal, BB; Salama, JK; Stenson, KM; Vokes, EE; Weichselbaum, RR; Witt, ME1
Bier, J; Gath, HJ; Oettle, H; Raguse, JD; Riess, H1
Brodsky, I; Rosenbluth, JZ; Styler, MJ; Zak, D1
Chmura, SJ; Haraf, DJ; Kao, J; Milano, MT; Salama, JK; Stenson, KM; Vokes, EE; Witt, ME1
Forkert, R; Fronhoffs, S; Ko, Y; Koll, C; Neuhaus, T; Stier, S; Tuohimaa, A; Vetter, H1
Gajewski, BJ; Mayo, MS1
Chun, PY; Davis, MA; Feng, FY; Lawrence, TS; Nyati, MK; Scheurer, AM1
Guo, Y; Hong, XN; Li, J; Tang, WY; Wang, JL1
Bielawska, A; Bielawski, J; Cobanoglu, B; Day, TA; Hannun, YA; Koybasi, S; Meyer, M; Obeid, LM; Ogretmen, B; Ponnusamy, S; Rossi, MJ; Senkal, CE; Sinha, D; Sundararaj, K; Szulc, Z1
Hennemann, B1
Angouridakis, N; Aravantinos, G; Bafaloukos, D; Bamias, A; Christodoulou, C; Dafni, U; Daniilidis, J; Economopoulos, T; Fountzilas, G; Kalofonos, H; Kalogera-Fountzila, A; Karina, M; Makatsoris, T; Maniadakis, N; Nikolaou, A; Papakostas, P; Pavlidis, N; Stathopoulos, G; Syrigos, K1
Cipolat, M; Colantonio, I; Di Costanzo, G; Fea, E; Garrone, O; Gasco, M; Granetto, C; Merlano, M; Numico, G; Occelli, M; Pelissero, A; Russi, EG; Sorrentino, R; Taglianti, RV; Vitiello, R1
Boswell, JS; Flam, MS; Tashjian, DN; Tschang, TP1
Bialewski, J; Hannun, YA; Jazwinski, SM; Jiang, JC; Ogretmen, B; Ponnusamy, S; Rossi, MJ; Senkal, CE; Sinha, D1
Chun, PY; Davis, MA; Feng, FY; Lawrence, TS; Li, X; Lopez, CA; Normolle, DP; Nyati, MK; Varambally, S1
Borel, C; Calais, G; Cupissol, D; Eymard, JC; Germann, N; Kohser, F; Labourey, JL; Tourani, JM; Tubiana-Mathieu, N1
Azim, HA; Elsedewy, E1
Dyck, J; Huizing, MT; Schrijvers, D; Specenier, PM; Van den Brande, J; Van den Weyngaert, D; Van Laer, C; Vermorken, JB; Weyler, J1
Gu, Y; Guo, Y; Hong, X; Hu, X; Li, J; Tang, W; Wang, B; Wang, J1
Bacigalupo, A; Benasso, M; Corvò, R; Marcenaro, M; Margarino, G; Ponzanelli, A; Vigo, V1
Erovic, BM; Heiduschka, G; Kloimstein, P; Martinek, H; Selzer, E; Skoda, C; Thurnher, D; Vormittag, L; Wachek, V; Wrba, F1
Boven, E; Braakhuis, BJ; Peters, GJ; Ruiz van Haperen, VW; Veerman, G1
Bergman, AM; Braakhuis, BJ; Kuiper, CM; Peters, GJ; Ruiz van Haperen, VW; Veerman, G1
Bruntsch, U; Catimel, G; Clavel, M; de Mulder, P; Judson, I; Piccart, M; Sessa, C; Vermorken, JB; Verweij, J; Wanders, J1
Braakhuis, BJ; Peters, GJ; Ruiz van Haperen, VW; Welters, MJ1
Eisbruch, A; Lawrence, TS; Shewach, DS1
Devriendt, D; Klastersky, J1
Athanassiades, A; Bacoyiannis, C; Briassoulis, E; Fountzilas, G; Kalogera-Fountzila, A; Kosmidis, P; Pavlidis, N; Samantas, E; Skarlos, D1
Alvarez Vincent, JJ; Brandariz, A; Castellano, D; Cortés-Funes, H; García-Carbonero, R; Hidalgo, M; Hitt, R; Millán, JM; Peña, M1
Ferguson, PJ; Hammond, JR; Lee, S1
Beauduin, M; Bruniaux, M; de Bast, M; de Coster, B; Grégoire, V; Octave-Prignot, M; Rosier, JF; Scalliet, P1
Bacoyiannis, C; Daniilidis, J; Fountzilas, G; Kalofonos, H; Kalogera-Fountzila, A; Kosmidis, P; Nicolaides, C; Nikolaou, A; Papadimitriou, C; Pavlidis, N; Samantas, E; Stathopoulos, G1
Khattab, J; Urba, SG1
Eisbruch, A; Fields, MT; Lawrence, TS; McGinn, CJ; Shewach, DS1
Bergman, AM; Kroep, JR; Peters, GJ; Pinedo, HM; Ruiz van Haperen, VW; van Moorsel, CJ; Veerman, G; Voorn, DA1
Davis, MA; Eisbruch, A; Fields, MT; Lawrence, TS; Normolle, D; Orfali, A; Pu, AT1
Glisson, BS; Hong, WK; Khuri, FR; Lippman, SM; Shin, DM1
Bradford, CR; Chepeha, DB; Dawson, LA; Eisbruch, A; Hogikyan, ND; Lawrence, TS; Littles, JF; Marentette, LJ; Shewach, DS; Teknos, TN; Terrell, JE; Urba, S; Wolf, GT1
Davis, MA; Hough, A; Lawrence, TS; Rehemtulla, A1
Ensley, JF; Giguere, JK; Gundacker, H; Kuebler, JP; Mills, GM; Samlowski, WE; Schuller, DE1
Allegretto, M; Mackey, JR; Selkaly, H1
Benasso, M; Corvò, R; Marchetti, G; Merlano, M; Numico, G; Pallestrini, E; Ricci, I; Rosso, R; Sanguineti, G; Santelli, A; Vitale, V1
Robbins, KT1
Bradford, CR; Chepeha, DB; Dawson, LA; Eisbruch, A; Haxer, MJ; Hogikyan, ND; Lyden, T; Miller, AE; Teknos, TN; Terrell, JE; Wolf, GT1
Noordhuis, P; Peters, GJ; Ruiz van Haperen, VW; Veerman, G; Vermorken, JB1
Braakhuis, BJ; Snow, GB; van Dongen, GA; Vermorken, JB1

Reviews

10 review(s) available for gemcitabine and Head and Neck Neoplasms

ArticleYear
Gemcitabine-Based Chemoradiation in the Treatment of Locally Advanced Head and Neck Cancer: Systematic Review of Literature and Meta-Analysis.
    The oncologist, 2016, Volume: 21, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Neoplasm Recurrence, Local; Radiation-Sensitizing Agents; Radiotherapy, Intensity-Modulated; Squamous Cell Carcinoma of Head and Neck

2016
Safety experience with IMC-C225, an anti-epidermal growth factor receptor antibody.
    Seminars in oncology, 2002, Volume: 29, Issue:5 Suppl 14

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Eruptions; Drug Hypersensitivity; Drug Interactions; Gemcitabine; Head and Neck Neoplasms; Humans; Irinotecan; Pancreatic Neoplasms

2002
Combination of gemcitabine and irinotecan for recurrent metastatic osteogenic sarcoma.
    Clinical advances in hematology & oncology : H&O, 2005, Volume: 3, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Cisplatin; Combined Modality Therapy; Deoxycytidine; Doxorubicin; Etoposide; Femoral Neoplasms; Gemcitabine; Head and Neck Neoplasms; Humans; Ifosfamide; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Palliative Care; Salvage Therapy; Scalp; Skin Neoplasms; Thoracotomy

2005
[Palliative chemotherapy of head and neck cancer: present status and future development].
    Laryngo- rhino- otologie, 2006, Volume: 85, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Deoxycytidine; Disease Progression; ErbB Receptors; Forecasting; Gefitinib; Gemcitabine; Head and Neck Neoplasms; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Palliative Care; Patient Selection; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Rats; Taxoids; Time Factors; Treatment Outcome; Vinblastine; Vinorelbine

2006
Imatinib in the treatment of follicular dendritic sarcoma: a case report and review of literature.
    Onkologie, 2007, Volume: 30, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Biomarkers, Tumor; Cisplatin; Dendritic Cells, Follicular; Deoxycytidine; Follow-Up Studies; Gemcitabine; Head and Neck Neoplasms; Humans; Imatinib Mesylate; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Piperazines; Positron-Emission Tomography; Proto-Oncogene Proteins c-kit; Pyrimidines; Sarcoma; Tomography, X-Ray Computed; Treatment Outcome

2007
Gemcitabine-mediated radiosensitization.
    Seminars in oncology, 1997, Volume: 24, Issue:2 Suppl 7

    Topics: Carcinoma, Squamous Cell; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Radiation-Sensitizing Agents; Research Design; Tumor Cells, Cultured

1997
New cytostatic agents for the treatment of head and neck cancer.
    Acta oto-rhino-laryngologica Belgica, 1997, Volume: 51, Issue:2

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Clinical Trials, Phase III as Topic; Deoxycytidine; Docetaxel; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Ifosfamide; Paclitaxel; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Taxoids

1997
Chemotherapy in head and neck cancer. Overview of newer agents.
    Hematology/oncology clinics of North America, 1999, Volume: 13, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Docetaxel; Gemcitabine; Head and Neck Neoplasms; Humans; Organoplatinum Compounds; Paclitaxel; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Taxoids; Topotecan; Vinblastine; Vinorelbine

1999
Radiosensitization by gemcitabine.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:10 Suppl 5

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Combined Modality Therapy; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasms; Pancreatic Neoplasms; Radiation-Sensitizing Agents; Ribonucleotide Reductases

1999
Treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck: current status and future directions.
    Seminars in oncology, 2000, Volume: 27, Issue:4 Suppl 8

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Deoxycytidine; Docetaxel; Gemcitabine; Head and Neck Neoplasms; Humans; Ifosfamide; Neoplasm Recurrence, Local; Paclitaxel; Taxoids; Vinblastine; Vinorelbine

2000

Trials

34 trial(s) available for gemcitabine and Head and Neck Neoplasms

ArticleYear
Rituximab in combination with gemcitabine plus cisplatin in patients with recurrent and metastatic head and neck squamous cell carcinoma: a phase I trial.
    BMC cancer, 2022, Feb-15, Volume: 22, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Disease-Free Survival; Drug Administration Schedule; Feasibility Studies; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Rituximab; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome

2022
Neoadjuvant toripalimab combined with gemcitabine and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoTGP01): An open label, single-arm, phase Ib clinical trial.
    Journal of experimental & clinical cancer research : CR, 2022, Oct-12, Volume: 41, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Immune Checkpoint Inhibitors; Neoadjuvant Therapy; Programmed Cell Death 1 Receptor; Receptors, Death Domain; Squamous Cell Carcinoma of Head and Neck

2022
Phase II trial of biweekly gemcitabine and paclitaxel with recurrent or metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group study S0329.
    Head & neck, 2014, Volume: 36, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Deoxycytidine; Disease-Free Survival; Drug Administration Schedule; Feasibility Studies; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome

2014
Phase II study on gemcitabine in recurrent and/or metastatic adenoid cystic carcinoma of the head and neck (EORTC 24982).
    European journal of cancer (Oxford, England : 1990), 2008, Volume: 44, Issue:17

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Adenoid Cystic; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Patient Compliance; Treatment Outcome

2008
Gemcitabine concurrent with radiation therapy for locally advanced head and neck carcinomas.
    African health sciences, 2008, Volume: 8, Issue:3

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Combined Modality Therapy; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Prospective Studies; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Treatment Outcome

2008
Promising overall survival of patients with recurrent/metastatic squamous cell carcinoma of head and neck receiving gemcitabine plus cisplatin treatment: report of a multi-center phase II study.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis

2010
A phase 2 study of pemetrexed plus gemcitabine every 2 weeks for patients with recurrent or metastatic head and neck squamous cell cancer.
    Cancer, 2011, Feb-15, Volume: 117, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinoma, Squamous Cell; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Glutamates; Guanine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms, Squamous Cell; Pemetrexed; Recurrence; Squamous Cell Carcinoma of Head and Neck

2011
Concomitant chemoradiotherapy using low-dose weekly gemcitabine versus low-dose weekly paclitaxel in locally advanced head and neck squamous cell carcinoma: a phase III study.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Chemoradiotherapy; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Paclitaxel; Young Adult

2012
Cetuximab concomitant with gemcitabine and radiotherapy in advanced squamous cell carcinomas of upper aerodigestive tract: a pilot study.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2011, Volume: 13, Issue:2

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cetuximab; Combined Modality Therapy; Deoxycytidine; Disease Progression; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Pilot Projects; Radiotherapy, Adjuvant; Survival Analysis; Treatment Outcome

2011
Phase II trial of pemetrexed-based induction chemotherapy followed by concomitant chemoradiotherapy in previously irradiated patients with squamous cell carcinoma of the head and neck.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Deoxycytidine; Female; Gemcitabine; Glutamates; Guanine; Head and Neck Neoplasms; Humans; Induction Chemotherapy; Male; Middle Aged; Neoplasm Recurrence, Local; Pemetrexed; Prospective Studies; Radiotherapy; Squamous Cell Carcinoma of Head and Neck

2011
Weekly gemcitabine and cisplatin in combination with radiotherapy in patients with locally advanced head-and-neck cancer: Phase I study.
    International journal of radiation oncology, biology, physics, 2011, Nov-15, Volume: 81, Issue:4

    Topics: Aged; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Deoxycytidine; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Prospective Studies; Radiation-Sensitizing Agents; Radiodermatitis; Radiotherapy, Conformal; Remission Induction; Stomatitis

2011
Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Sep-15, Volume: 17, Issue:18

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Carcinoma, Squamous Cell; Ceramides; Deoxycytidine; Doxorubicin; Gemcitabine; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Middle Aged; Recurrence; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome

2011
Concurrent radiotherapy and chemotherapy for locally advanced squamous cell carcinoma of the head and neck.
    Head & neck oncology, 2011, Nov-15, Volume: 3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Prospective Studies; Radiation-Sensitizing Agents; Young Adult

2011
Gemcitabine-based induction chemotherapy and concurrent with radiation in advanced head and neck cancer.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Induction Chemotherapy; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging

2012
Phase II trial of gemcitabine concurrent with radiation for locally advanced squamous cell carcinoma of the head and neck.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Radiation Injuries; Ribonucleotide Reductases; Treatment Outcome

2004
Alternating gemcitabine and cisplatin with gemcitabine and radiation in stage IV squamous cell carcinoma of the head and neck.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:4

    Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Deoxycytidine; Female; Fever; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Staging; Neoplasms, Squamous Cell; Neutropenia; Survival Analysis; Survival Rate; Thrombocytopenia; Treatment Outcome

2004
Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, gemcitabine, and twice-daily radiation in patients with poor-prognosis cancer of the head and neck.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-01, Volume: 10, Issue:15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Disease Progression; Disease-Free Survival; Female; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Paclitaxel; Prognosis; Radiometry; Time Factors; Treatment Outcome

2004
Gemcitabine plus vinorelbine chemotherapy regimens: a pharmacokinetic study of alternate administration sequences.
    Pharmacy world & science : PWS, 2004, Volume: 26, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Forecasting; Gemcitabine; Half-Life; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Italy; Kinetics; Lymphoma, Non-Hodgkin; Vinblastine; Vinorelbine

2004
Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT?
    International journal of radiation oncology, biology, physics, 2004, Dec-01, Volume: 60, Issue:5

    Topics: Antimetabolites, Antineoplastic; Combined Modality Therapy; Deglutition; Deglutition Disorders; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Hypopharynx; Image Processing, Computer-Assisted; Palatine Tonsil; Pharyngeal Muscles; Pneumonia, Aspiration; Prospective Studies; Radiotherapy, Conformal; Tongue

2004
Twice-daily reirradiation for recurrent and second primary head-and-neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy.
    International journal of radiation oncology, biology, physics, 2005, Mar-15, Volume: 61, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Paclitaxel; Radiotherapy Dosage

2005
Gemcitabine in the treatment of advanced head and neck cancer.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2005, Volume: 17, Issue:6

    Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Quality of Life; Radiotherapy; Salvage Therapy; Survival Rate; Treatment Outcome

2005
Gemcitabine and paclitaxel in metastatic or recurrent squamous cell carcinoma of the head and neck: a phase I-II study.
    Anti-cancer drugs, 2005, Volume: 16, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Paclitaxel

2005
Paclitaxel and gemcitabine vs. paclitaxel and pegylated liposomal doxorubicin in advanced non-nasopharyngeal head and neck cancer. An efficacy and cost analysis randomized study conducted by the Hellenic Cooperative Oncology Group.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cost-Benefit Analysis; Deoxycytidine; Doxorubicin; Female; Gemcitabine; Greece; Head and Neck Neoplasms; Humans; Male; Middle Aged; Paclitaxel; Patient Compliance; Polyethylene Glycols; Survival Analysis; Treatment Outcome

2006
Docetaxel plus gemcitabine in recurrent and/or metastatic squamous cell carcinoma of the head and neck: a phase II multicenter study.
    American journal of clinical oncology, 2007, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Deoxycytidine; Docetaxel; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Male; Middle Aged; Pharyngeal Neoplasms; Recurrence; Taxoids; Treatment Outcome

2007
Phase II feasibility study of concurrent radiotherapy and gemcitabine in chemonaive patients with squamous cell carcinoma of the head and neck: long-term follow up data.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:11

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Deoxycytidine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Feasibility Studies; Female; Follow-Up Studies; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Radiotherapy Dosage; Radiotherapy, Adjuvant; Risk Assessment; Survival Analysis; Time Factors

2007
A phase II trial of low-dose gemcitabine and radiation alternated to cisplatin and 5-fluorouracil: an active and manageable regimen for stage IV squamous cell carcinoma of the head and neck.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2008, Volume: 89, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Survival Rate; Treatment Outcome

2008
A phase II study of Gemcitabine (LY 188011) in patients with advanced squamous cell carcinoma of the head and neck. EORTC Early Clinical Trials Group.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1994, Volume: 5, Issue:6

    Topics: Adult; Aged; Alanine Transaminase; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Carcinoma, Squamous Cell; Deoxycytidine; Europe; Fatigue; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Liver; Male; Middle Aged; Neutropenia; Remission Induction

1994
Paclitaxel in combination with carboplatin or gemcitabine for the treatment of advanced head and neck cancer.
    Seminars in oncology, 1997, Volume: 24, Issue:6 Suppl 19

    Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Immunosuppression Therapy; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Paclitaxel

1997
Phase II trial of cisplatin and gemcitabine in advanced squamous-cell carcinoma of the head and neck.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1998, Volume: 9, Issue:12

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Bone Marrow Diseases; Carcinoma, Squamous Cell; Combined Modality Therapy; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Salvage Therapy; Treatment Outcome

1998
Paclitaxel and gemcitabine in advanced non-nasopharyngeal head and neck cancer: a phase II study conducted by the Hellenic Cooperative Oncology Group.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Greece; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Paclitaxel; Prognosis; Survival Rate

1999
Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biopsy; Combined Modality Therapy; Cytosine Nucleotides; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Radiation-Sensitizing Agents; Radiotherapy

2001
Evaluation of gemcitabine in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group phase II study.
    Investigational new drugs, 2001, Volume: 19, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Deoxycytidine; Drug Evaluation; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Ribonucleotide Reductases; Survival Rate

2001
Gemcitabine, cisplatin, and radiation in advanced, unresectable squamous cell carcinoma of the head and neck: a feasibility study.
    American journal of clinical oncology, 2001, Volume: 24, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Deoxycytidine; Dose Fractionation, Radiation; Feasibility Studies; Female; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Remission Induction; Survival Analysis

2001
Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2002, May-01, Volume: 53, Issue:1

    Topics: Combined Modality Therapy; Deglutition; Deglutition Disorders; Deoxycytidine; Fluoroscopy; Gemcitabine; Head and Neck Neoplasms; Humans; Pneumonia, Aspiration; Prospective Studies; Radiation-Sensitizing Agents

2002

Other Studies

41 other study(ies) available for gemcitabine and Head and Neck Neoplasms

ArticleYear
Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer.
    Cancer immunology, immunotherapy : CII, 2023, Volume: 72, Issue:8

    Topics: Animals; B7-H1 Antigen; Cell Line, Tumor; Epitopes; Gemcitabine; Head and Neck Neoplasms; Immunotherapy; Mice; Programmed Cell Death 1 Receptor; Squamous Cell Carcinoma of Head and Neck

2023
Re-irradiation with 36 Gy (1.5 Gy Twice Daily) Plus Paclitaxel for Advanced Recurrent and Previously Irradiated SCCHN is Feasible.
    Anticancer research, 2018, Volume: 38, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Chemoradiotherapy; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Neoplasm Recurrence, Local; Paclitaxel; Re-Irradiation; Squamous Cell Carcinoma of Head and Neck

2018
Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Deoxycytidine; DNA-Directed DNA Polymerase; Drug Resistance, Neoplasm; Epithelial Cells; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Male; Middle Aged; Prognosis; Squamous Cell Carcinoma of Head and Neck

2013
Identification and characterization of cancer stem cells in human head and neck squamous cell carcinoma.
    BMC cancer, 2014, Mar-11, Volume: 14

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; CD24 Antigen; Cell Line, Tumor; Cisplatin; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Hyaluronan Receptors; Mice; Mice, Nude; Neoplastic Stem Cells

2014
Recurrent low-dose chemotherapy to inhibit and oxygenate head and neck tumors.
    Advances in experimental medicine and biology, 2014, Volume: 812

    Topics: Animals; Antineoplastic Agents; Deoxycytidine; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Gemcitabine; Head and Neck Neoplasms; Heterografts; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Oxygen

2014
DNA microarray reveals ZNF195 and SBF1 are potential biomarkers for gemcitabine sensitivity in head and neck squamous cell carcinoma cell lines.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:4

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Deoxycytidine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gemcitabine; Head and Neck Neoplasms; Humans; Intracellular Signaling Peptides and Proteins; Kruppel-Like Transcription Factors; Oligonucleotide Array Sequence Analysis; Treatment Outcome; Zinc Fingers

2014
Survival prognostic factors for metachronous second primary head and neck squamous cell carcinoma.
    Cancer medicine, 2017, Volume: 6, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Deoxycytidine; Docetaxel; Female; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Hydroxyurea; Male; Methotrexate; Middle Aged; Neoplasm Staging; Neoplasms, Second Primary; Paclitaxel; Prognosis; Squamous Cell Carcinoma of Head and Neck; Survival Analysis; Taxoids; Treatment Outcome; Young Adult

2017
Craniocervical paraganglioma with numerous pulmonary metastases--case report.
    Neurologia medico-chirurgica, 2008, Volume: 48, Issue:9

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cervical Vertebrae; Combined Modality Therapy; Deoxycytidine; Gemcitabine; Glomus Jugulare Tumor; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Paclitaxel; Paraganglioma; Treatment Outcome

2008
A non-randomized comparison of gemcitabine-based chemoradiation with or without induction chemotherapy for locally advanced squamous cell carcinoma of the head and neck.
    BMC cancer, 2009, Aug-06, Volume: 9

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cisplatin; Cohort Studies; Combined Modality Therapy; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Radiation-Sensitizing Agents; Treatment Outcome

2009
In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells.
    BMC cancer, 2010, Aug-19, Volume: 10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle; Cell Proliferation; Combined Modality Therapy; Deoxycytidine; Drug Interactions; Drug Synergism; Flow Cytometry; Gemcitabine; Glutamates; Guanine; Head and Neck Neoplasms; Humans; In Vitro Techniques; Lung Neoplasms; Pemetrexed; Radiotherapy Dosage; Tumor Cells, Cultured

2010
Difluorodeoxyuridine plasma concentrations after low-dose gemcitabine during chemoradiation in head and neck cancer patients.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:1

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Radiation-Sensitizing Agents

2011
Angiosarcoma of the scalp with complete response to a biweekly gemcitabine and docetaxel (GEMDOC) chemotherapy regimen.
    Ear, nose, & throat journal, 2011, Volume: 90, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Docetaxel; Female; Gemcitabine; Head and Neck Neoplasms; Hemangiosarcoma; Humans; Scalp; Skin Neoplasms; Taxoids

2011
Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-15, Volume: 17, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Biomimetic Materials; Blotting, Western; Caspase 3; Cell Line, Tumor; Cytochromes c; Deoxycytidine; Drug Synergism; Enzyme Activation; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Nude; Mitochondria; Mitochondrial Proteins; RNA Interference; Signal Transduction; Xenograft Model Antitumor Assays

2011
MDM2 309 polymorphism predicts outcome in platinum-treated locally advanced head and neck cancer.
    Oral oncology, 2012, Volume: 48, Issue:7

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cetuximab; Cisplatin; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Gemcitabine; Genes, p53; Head and Neck Neoplasms; Humans; Male; Middle Aged; Mutation; Paclitaxel; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Prognosis; Proto-Oncogene Proteins c-mdm2; Treatment Outcome; Young Adult

2012
First-line combination of gemcitabine, oxaliplatin, and L-asparaginase (GELOX) followed by involved-field radiation therapy for patients with stage IE/IIE extranodal natural killer/T-cell lymphoma.
    Cancer, 2013, Jan-15, Volume: 119, Issue:2

    Topics: Adult; Aged; Aluminum Hydroxide; Antineoplastic Combined Chemotherapy Protocols; Bentonite; Chemoradiotherapy; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Induction Chemotherapy; Kaplan-Meier Estimate; Lymphoma, Extranodal NK-T-Cell; Magnesium Hydroxide; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Treatment Outcome; Young Adult

2013
Alternating chemotherapy: gemcitabine and cisplatin with concurrent radiotherapy for treatment of advanced head and neck cancer.
    Oral oncology, 2013, Volume: 49, Issue:3

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Deglutition Disorders; Deoxycytidine; Disease Progression; Female; Fluorouracil; Follow-Up Studies; Gemcitabine; Head and Neck Neoplasms; Humans; Induction Chemotherapy; Leukopenia; Male; Middle Aged; Neoplasm Staging; Radiation-Sensitizing Agents; Radiodermatitis; Radiotherapy Dosage; Remission Induction; Safety; Stomatitis; Survival Rate; Treatment Outcome; Xerostomia

2013
The radioenhancement of two human head and neck squamous cell carcinomas by 2'-2' difluorodeoxycytidine (gemcitabine; dFdC) is mediated by an increase in radiation-induced residual chromosome aberrations but not residual DNA DSBs.
    Mutation research, 2003, Jun-19, Volume: 527, Issue:1-2

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Chromosome Aberrations; Combined Modality Therapy; Deoxycytidine; DNA Damage; DNA, Neoplasm; Gemcitabine; Head and Neck Neoplasms; Humans; Radiation Tolerance; Radiation-Sensitizing Agents; Radiation, Ionizing; Time Factors; Tumor Cells, Cultured

2003
Role of 2'-2' difluorodeoxycytidine (gemcitabine)-induced cell cycle dysregulation in radio-enhancement of human head and neck squamous cell carcinomas.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 70, Issue:1

    Topics: Carcinoma, Squamous Cell; Cell Cycle; Deoxycytidine; Flow Cytometry; Gemcitabine; Head and Neck Neoplasms; Humans; Radiation-Sensitizing Agents; Tumor Cells, Cultured

2004
Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma.
    International journal of radiation oncology, biology, physics, 2006, Feb-01, Volume: 64, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Camptothecin; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Hydroxyurea; Irinotecan; Male; Mandibular Diseases; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Osteoradionecrosis; Paclitaxel; Prognosis; Radiotherapy Dosage; Treatment Failure; Treatment Outcome

2006
Bayesian sample size calculations in phase II clinical trials using a mixture of informative priors.
    Statistics in medicine, 2006, Aug-15, Volume: 25, Issue:15

    Topics: Algorithms; Antineoplastic Agents; Bayes Theorem; Clinical Trials, Phase II as Topic; Computer Simulation; Deoxycytidine; Docetaxel; Gemcitabine; Head and Neck Neoplasms; Humans; Leiomyosarcoma; Organoplatinum Compounds; Oxaliplatin; Sample Size; Taxoids

2006
Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma.
    Cancer research, 2006, Jan-15, Volume: 66, Issue:2

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Deoxycytidine; Drug Administration Schedule; Drug Interactions; ErbB Receptors; Gefitinib; Gemcitabine; Head and Neck Neoplasms; Humans; Quinazolines; Tumor Cells, Cultured

2006
[Experience of gemcitabine plus cisplatin chemotherapy in 52 patients with head and neck cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2005, Volume: 27, Issue:9

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Metastasis

2005
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cations; Cell Line, Tumor; Cell Proliferation; Ceramides; Deoxycytidine; Dose-Response Relationship, Drug; Gemcitabine; Head and Neck Neoplasms; Humans; Inactivation, Metabolic; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasms, Squamous Cell; Pyridinium Compounds; Tissue Distribution; Xenograft Model Antitumor Assays

2006
Gemcitabine and cisplatin in a concomitant alternating chemoradiotherapy program for locally advanced head-and-neck cancer: a pharmacology-guided schedule.
    International journal of radiation oncology, biology, physics, 2006, Nov-01, Volume: 66, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Deoxycytidine; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Male; Middle Aged; Mouth Neoplasms; Neoplasm Recurrence, Local; Neutropenia; Pharyngeal Neoplasms; Stomatitis

2006
Basal cell carcinoma metastatic to cervical lymph nodes and lungs.
    Dermatology online journal, 2006, Oct-31, Volume: 12, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy, Fine-Needle; Carboplatin; Carcinoma, Basal Cell; Carcinoma, Papillary; Deoxycytidine; Diagnostic Errors; Docetaxel; Gemcitabine; Head and Neck Neoplasms; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neck Dissection; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Radiotherapy; Seminoma; Skin Neoplasms; Taxoids; Testicular Neoplasms; Thyroid Neoplasms; Thyroidectomy; Unnecessary Procedures

2006
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Caspases; Cell Line, Tumor; Ceramides; Chromatography, High Pressure Liquid; Chromatography, Liquid; Deoxycytidine; Doxorubicin; Fluorescent Antibody Technique; Gemcitabine; Head and Neck Neoplasms; Humans; Membrane Proteins; Mice; Mice, SCID; Oxidoreductases; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sphingosine N-Acyltransferase; Survival Rate

2007
Effect of epidermal growth factor receptor inhibitor class in the treatment of head and neck cancer with concurrent radiochemotherapy in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Apr-15, Volume: 13, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Combined Modality Therapy; Deoxycytidine; ErbB Receptors; Gefitinib; Gemcitabine; Head and Neck Neoplasms; Mice; Mice, Nude; Quinazolines; Rats; Transplantation, Heterologous

2007
Retrospective case series of gemcitabine plus cisplatin in the treatment of recurrent and metastatic nasopharyngeal carcinoma.
    Oral oncology, 2008, Volume: 44, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Retrospective Studies; Survival Rate; Treatment Outcome

2008
Down-regulation of Mcl-1 with antisense technology alters the effect of various cytotoxic agents used in treatment of squamous cell carcinoma of the head and neck.
    Oncology reports, 2008, Volume: 19, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Carcinoma, Squamous Cell; Cell Survival; Cetuximab; Cisplatin; Combined Modality Therapy; Deoxycytidine; Down-Regulation; Fluorouracil; Gemcitabine; Head and Neck Neoplasms; Humans; Immunoenzyme Techniques; Myeloid Cell Leukemia Sequence 1 Protein; Oligonucleotides, Antisense; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured

2008
Schedule-dependent antitumor effect of gemcitabine in in vivo model system.
    Seminars in oncology, 1995, Volume: 22, Issue:4 Suppl 11

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Carcinoma, Squamous Cell; Colonic Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Sarcoma; Soft Tissue Neoplasms

1995
Interaction between cisplatin and gemcitabine in vitro and in vivo.
    Seminars in oncology, 1995, Volume: 22, Issue:4 Suppl 11

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cisplatin; Colonic Neoplasms; Deoxycytidine; DNA Damage; DNA, Neoplasm; Drug Administration Schedule; Drug Resistance, Neoplasm; Drug Synergism; Drug Tolerance; Female; Fluorometry; Gemcitabine; Head and Neck Neoplasms; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Tumor Cells, Cultured

1995
Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts.
    European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:13-14

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Transplantation, Heterologous; Tumor Cells, Cultured

1995
[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Carrier Proteins; Deoxycytidine; Drug Resistance; Formycins; Gemcitabine; Head and Neck Neoplasms; Humans; Membrane Proteins; Nucleoside Transport Proteins; Time Factors; Tritium; Tumor Cells, Cultured; Uridine

1999
The effect of 2'-2' difluorodeoxycytidine (dFdC, gemcitabine) on radiation-induced cell lethality in two human head and neck squamous carcinoma cell lines differing in intrinsic radiosensitivity.
    International journal of radiation biology, 1999, Volume: 75, Issue:2

    Topics: Carcinoma, Squamous Cell; Cell Death; Combined Modality Therapy; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured

1999
Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.
    Biochimica et biophysica acta, 2000, Mar-06, Volume: 1474, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Leukemia; Lung Neoplasms; Mice; Ovarian Neoplasms; Rats; Ribonucleotide Reductases; Ribonucleotides; Tumor Cells, Cultured

2000
Radiosensitization produced in vivo by once- vs. twice-weekly 2'2'-difluoro-2'-deoxycytidine (gemcitabine).
    International journal of radiation oncology, biology, physics, 2000, Jun-01, Volume: 47, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Carcinoma, Squamous Cell; Combined Modality Therapy; Deoxycytidine; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Gemcitabine; Head and Neck Neoplasms; Lip; Mice; Mice, Inbred C3H; Mouth Mucosa; Radiation Tolerance; Radiation-Sensitizing Agents; Weight Loss

2000
The role of apoptosis in 2',2'-difluoro-2'-deoxycytidine (gemcitabine)-mediated radiosensitization.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:2

    Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cobalt Radioisotopes; Colonic Neoplasms; Coumarins; Deoxycytidine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Radiation; Electrophoresis, Gel, Pulsed-Field; Enzyme Activation; Gemcitabine; Head and Neck Neoplasms; Humans; Lung Neoplasms; Oligopeptides; Radiation-Sensitizing Agents; Tumor Cells, Cultured

2001
Intraoperative saline and gemcitabine irrigation improves tumour control in human squamous cell carcinoma-contaminated surgical wounds.
    The Journal of otolaryngology, 2001, Volume: 30, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Intraoperative Care; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Seeding; Neoplasm Transplantation; Sodium Chloride; Therapeutic Irrigation; Transplantation, Heterologous; Water

2001
Barriers to winning the battle with head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2002, May-01, Volume: 53, Issue:1

    Topics: Clinical Trials, Phase I as Topic; Deglutition; Deglutition Disorders; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Radiation-Sensitizing Agents

2002
Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (gemcitabine).
    Advances in experimental medicine and biology, 1991, Volume: 309A

    Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Carcinoma, Squamous Cell; Cell Division; Cell Line; Colonic Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Kinetics; Mice; Ovarian Neoplasms

1991
Preclinical in vivo activity of 2',2'-difluorodeoxycytidine (Gemcitabine) against human head and neck cancer.
    Cancer research, 1991, Jan-01, Volume: 51, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Gemcitabine; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation

1991