Page last updated: 2024-08-24

gemcitabine and Disease Models, Animal

gemcitabine has been researched along with Disease Models, Animal in 233 studies

Research

Studies (233)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (0.43)18.2507
2000's47 (20.17)29.6817
2010's151 (64.81)24.3611
2020's34 (14.59)2.80

Authors

AuthorsStudies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Fan, D; Fan, Y; Fang, Z; Gao, X; Li, X; Liu, J; Yan, K1
Chen, R; He, R; Hu, C; Li, G; Li, T; Li, Z; Lin, Q; Xia, R; Ye, Y; Zhang, X; Zheng, S1
Abi Jaoude, J; Delahoussaye, AM; Feng, N; Fowlkes, N; Fujimoto, TN; Garcia Garcia, CJ; Gay, JP; Green, M; Marszalek, J; Molkentine, J; Taniguchi, CM1
Hong, SS; Kang, CM; Kim, D; Kim, S; Lee, J; Lee, JH; Lee, S; Lee, SH; Park, H1
Shen, R; Sun, C; Tang, C; Tang, Z; Ying, X1
Cao, Z; Feng, M; Liu, Y; Qiu, J; Yang, G; You, L; Zhang, T1
Ding, J; Dong, L; Fu, L; Li, Z; Ma, Z; Wu, Y; Yu, G; Zhang, C; Zhu, T1
Guan, J; Guan, X; Jiang, X; Jiao, Z; Li, L; Long, B; Ma, Y; Qin, L; Shi, W; Wang, J; Wang, K; Wang, T; Yang, J; Ye, H; Yu, Z; Zhou, H1
Bai, Y; Dal, E; Li, K; Li, X; Lin, R; Liu, N; Liu, Z; Qi, R; Shi, B; Wang, H; Wang, X; Wang, Y; Xu, Y1
Cho, IR; Choi, JH; Hong, JM; Kim, YT; Lee, SH; Nam, GH; Paik, WH; Ryu, JK1
Ha Hwang, J; Khokhlova, TD; Son, H; Totten, S; Wang, YN; Whang, S1
Bai, W; Chang, A; Fu, D; Gao, S; Hao, J; Hou, X; Huang, C; Jiang, W; Li, X; Liu, J; Liu, Z; Man, Q; Sun, H; Sun, J; Wang, H; Wang, X; Wang, Y; Xie, Y; Yan, J; Yang, S; Zhang, X; Zhang, Z; Zhao, T; Zhou, T1
Agyare, E; Bulusu, R; Frimpong, E; Han, B; Inkoom, A; Ndemazie, NB; Poku, R; Smith, T; Trevino, J; Zhu, X1
Akita, H; Asaoka, T; Doki, Y; Eguchi, H; Gotoh, K; Iwagami, Y; Kobayashi, S; Nishi, H; Noda, T; Sasaki, K; Takahashi, H; Tanemura, M; Tomimaru, Y; Yamada, D1
Chen, CP; Hsiao, YT; Huang, WK; Lo, CH; Pan, YR; Wu, CE; Yeh, CN1
Cardoso, ACF; Florez Bedoya, CA; Fogelman, D; Katz, MHG; Kim, MP; Ngo-Huang, A; Park, M; Parker, N; Petzel, MQ; Romero, SG; Schadler, KL; Wang, H1
Berkenstam, A; Dai, B; DiLorenzo, S; Fleming, J; Hases, L; Ibrahim, A; Jafferali, MH; Jose Augustine, J; Kang, Y; Kim, M; Lin, CY; Mesmar, F; Wang, J; Williams, C; Zhao, Y1
Bouvet, M; Chawla, SP; Higuchi, T; Hoffman, RM; Kawaguchi, K; Miyake, K; Oshiro, H; Park, JH; Singh, SR; Sugisawa, N; Unno, M; Zhang, Z1
Digiovanni, MG; Lacomb, JF; Luo, D; Mackenzie, GG; Rigas, B; Wei, R; Williams, JL1
Hussein, A; Razavi, M; Ren, G; Rezaee, M; Thakor, AS; Ullah, M; Wang, J; Zheng, F1
Chauhan, B; Chauhan, N; Chauhan, SC; Halaweish, FT; Jaggi, M; Khan, P; Khan, S; Kumari, S; Malik, S; Sikander, M; Yallapu, MM1
Gowda, PS; Javed, A; Li, J; Lu, Y; Ponnazhagan, S; Trotter, TN; Xu, X; Yang, Y; Zhang, C1
Caprioli, R; Dai, X; Dosch, AR; Kashikar, N; Kwon, D; Mehra, S; Merchant, NB; Nagathihalli, NS; Reyzer, ML; Srinivasan, S; Willobee, BA1
Gibbs, SL; King, D; Solanki, A; Thibault, G; Wang, L1
Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; Quigg, A; Raee, E; Raibaud, P; Ramanitrahasimbola, D; Rapoport, L; Rasby, RJ; Rasoanirina, BNV; Raspini, B; Ratner, JR; Razafindrakoto, Z; Redd, MA; Ren, H; Ren, N; Rey, J; Reynolds, CP; Rich, PR; Richards, CJ; Rigol, M; Rimoldi, S; Robert, P; Rodrigues, AE; Roe, JH; Rohde, S; Rokita, JL; Roland, J; Rombaut, L; Ronkainen, J; Rothenberg, SM; Roy, SC; Ruan, Z; Rucker, PV; Rueda, D; Ruhwald, M; Rungrotmongkol, T; Rupert, AS; Rusjan, P; Ryabov, AD; Rysä, J; Saad, NES; Sabioni, P; Sadow, PM; Sahai, N; Salem, HF; Salinas, B; Salonurmi, T; Samé Guerra, D; Sánchez, J; Sanchez-González, J; Sanmamed, MF; Sansores-Peraza, P; Santoro, JC; Santschi, PH; Saritas, T; Sarkisova, Y; Savolainen, MJ; Scherberich, JE; Schlom, DG; Schmelz, EM; Schmid, MC; Schneider, MP; Schumacher, S; Schwartz, JC; Schwartzer, JJ; Schwehr, K; Schweitzer, DH; Scott, ME; Sedky, NK; See Hoe, L; Sejian, V; Selvaraju, S; Sen, SK; Seo, G; Šerý, O; Settles, JA; Sfar, S; Shaffer, J; Shan, GL; Shang, Q; Shannahan, JH; Shao, B; Shao, H; 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Di, Y; Fu, D; Hu, J; Jiang, Y; Jin, C; Li, J; Ni, Q; Wang, C; Yang, D; Yang, F1
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Reviews

4 review(s) available for gemcitabine and Disease Models, Animal

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

2016
New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review.
    International journal of molecular sciences, 2018, Aug-21, Volume: 19, Issue:9

    Topics: Activating Transcription Factor 6; Animals; Antibodies; Carcinoma, Pancreatic Ductal; Communicable Diseases; Deoxycytidine; Diabetes Complications; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Gemcitabine; Gene Expression Regulation; Heat-Shock Proteins; Humans; Pancreatic Neoplasms; Pancreatitis, Chronic; Protein Serine-Threonine Kinases; Risk Factors; RNA, Small Interfering; Sulfones

2018
Chemoprevention strategies for pancreatic cancer.
    Nature reviews. Gastroenterology & hepatology, 2010, Volume: 7, Issue:6

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; beta Carotene; Camellia sinensis; Celecoxib; Cell Transformation, Neoplastic; Chemoprevention; Curcumin; Cyclooxygenase 2 Inhibitors; Deoxycytidine; Disease Models, Animal; Down-Regulation; Drug Synergism; Gemcitabine; Humans; Isothiocyanates; Pancreatic Neoplasms; Phototherapy; Pyrazoles; Sulfonamides; Tea; Vitamin D; Vitamin E

2010
Recent advances in the use of radiosensitizing nucleosides.
    Seminars in radiation oncology, 2001, Volume: 11, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Disease Models, Animal; Fluorouracil; Gemcitabine; Humans; Neoplasms; Radiation-Sensitizing Agents

2001

Trials

4 trial(s) available for gemcitabine and Disease Models, Animal

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

2016
Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma.
    Annals of surgical oncology, 2020, Volume: 27, Issue:11

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Electrochemotherapy; Fluorouracil; Gemcitabine; Humans; Irinotecan; Leucovorin; Mice; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome

2020
SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Nov-01, Volume: 21, Issue:21

    Topics: Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Gene Expression; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Mice, Knockout; Neoplasm Metastasis; Osteonectin; Paclitaxel; Pancreatic Neoplasms; Stromal Cells; Treatment Outcome; Xenograft Model Antitumor Assays

2015
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans.
    Science (New York, N.Y.), 2011, Mar-25, Volume: 331, Issue:6024

    Topics: Adult; Aged; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; CD40 Antigens; Deoxycytidine; Disease Models, Animal; Disease-Free Survival; Female; Gemcitabine; Humans; Immunologic Surveillance; Macrophage Activation; Macrophages; Male; Mice; Middle Aged; Pancreatic Neoplasms; T-Lymphocytes; Tumor Microenvironment; Young Adult

2011

Other Studies

226 other study(ies) available for gemcitabine and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway.
    Oncology reports, 2022, Volume: 47, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Berberine; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Down-Regulation; Drug Synergism; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rad51 Recombinase; Up-Regulation; Urinary Bladder Neoplasms

2022
circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis.
    Molecular cancer, 2022, 01-19, Volume: 21, Issue:1

    Topics: Animals; Cancer-Associated Fibroblasts; Caveolin 1; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Leukemia Inhibitory Factor; Mice; MicroRNAs; Models, Biological; Pancreatic Neoplasms; Rho Guanine Nucleotide Exchange Factors; RNA Interference; RNA, Circular; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays

2022
Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.
    BMC cancer, 2022, Feb-16, Volume: 22, Issue:1

    Topics: Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Feasibility Studies; Fluorouracil; Gemcitabine; Humans; Irinotecan; Leucovorin; Mice; Oxaliplatin; Paclitaxel; Pancreatic Neoplasms

2022
Anticancer effect of locally applicable aptamer-conjugated gemcitabine-loaded atelocollagen patch in pancreatic cancer patient-derived xenograft models.
    Cancer science, 2022, Volume: 113, Issue:5

    Topics: Animals; Cell Line, Tumor; Collagen; Deoxycytidine; Disease Models, Animal; Gemcitabine; Heterografts; Humans; Pancreatic Neoplasms; Xenograft Model Antitumor Assays

2022
M1 macrophage-derived exosomes synergistically enhance the anti- bladder cancer effect of gemcitabine.
    Aging, 2022, 08-03, Volume: 14, Issue:18

    Topics: Animals; Antineoplastic Agents; bcl-2-Associated X Protein; Caspase 3; Cytokines; Deoxycytidine; Disease Models, Animal; Exosomes; Gemcitabine; Macrophages; Mice; Urinary Bladder Neoplasms

2022
mTOR inhibitor, gemcitabine and PD-L1 antibody blockade combination therapy suppresses pancreatic cancer progression via metabolic reprogramming and immune microenvironment remodeling in Trp53
    Cancer letters, 2023, 02-01, Volume: 554

    Topics: Animals; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Disease Models, Animal; Gemcitabine; Mice; Pancreatic Neoplasms; Sirolimus; TOR Serine-Threonine Kinases; Tumor Microenvironment

2023
Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
    Biochemical genetics, 2023, Volume: 61, Issue:4

    Topics: 3' Untranslated Regions; Adenocarcinoma of Lung; Animals; Autophagy; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Gemcitabine; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; MicroRNAs

2023
Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress.
    Gastroenterology, 2023, Volume: 164, Issue:7

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Gemcitabine; Humans; Mice; Pancreatic Neoplasms; Tumor Suppressor Protein p53; Ubiquitin-Conjugating Enzymes

2023
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs.
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2023, Volume: 68

    Topics: Animals; Cancer-Associated Fibroblasts; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Coenzyme A Ligases; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Exosomes; Ferroptosis; Gemcitabine; Humans; Mice; MicroRNAs; Pancreatic Neoplasms

2023
Cytokine-Induced Killer Cell Immunotherapy Combined With Gemcitabine Reduces Systemic Metastasis in Pancreatic Cancer: An Analysis Using Preclinical Adjuvant Therapy-Mimicking Pancreatic Cancer Xenograft Model.
    Pancreas, 2022, 10-01, Volume: 51, Issue:9

    Topics: Animals; Cytokine-Induced Killer Cells; Disease Models, Animal; Gemcitabine; Heterografts; Humans; Immunotherapy; Immunotherapy, Adoptive; Mice; Pancreatic Neoplasms

2022
Chronic effects of pulsed high intensity focused ultrasound aided delivery of gemcitabine in a mouse model of pancreatic cancer.
    Ultrasonics, 2023, Volume: 132

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Gemcitabine; High-Intensity Focused Ultrasound Ablation; Mice; Pancreatic Neoplasms; Tumor Microenvironment

2023
Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis.
    Journal of experimental & clinical cancer research : CR, 2023, May-04, Volume: 42, Issue:1

    Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Animal; Gemcitabine; Humans; Irbesartan; Mice; Pancreatic Neoplasms; Retrospective Studies

2023
Biological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer.
    BMC cancer, 2023, May-13, Volume: 23, Issue:1

    Topics: Animals; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Heterografts; Humans; Mice; Nanoparticles; Pancreatic Neoplasms; Xenograft Model Antitumor Assays

2023
Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma.
    Cancer chemotherapy and pharmacology, 2023, Volume: 92, Issue:4

    Topics: Animals; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Humans; Mice; Pancreatic Neoplasms; Thalidomide; Xenograft Model Antitumor Assays

2023
Wee1 inhibition by MK1775 potentiates gemcitabine through accumulated replication stress leading to apoptosis in biliary tract cancer.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 166

    Topics: Animals; Apoptosis; Biliary Tract Neoplasms; Disease Models, Animal; Gemcitabine; Humans; Mice; Tumor Suppressor Protein p53

2023
Exercise during preoperative therapy increases tumor vascularity in pancreatic tumor patients.
    Scientific reports, 2019, 09-27, Volume: 9, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Exercise; Gemcitabine; Humans; Mice; Pancreatic Neoplasms; Physical Conditioning, Animal; Vascular Remodeling; Xenograft Model Antitumor Assays

2019
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.
    Cancer medicine, 2019, Volume: 8, Issue:18

    Topics: Animals; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Synergism; Female; Gemcitabine; Genistein; Humans; Mice; Models, Biological; Mucin-1; Pancreatic Neoplasms; Protein Kinase Inhibitors; Receptors, Estrogen; Signal Transduction; Xenograft Model Antitumor Assays

2019
Induction of Metastasis by Low-dose Gemcitabine in a Pancreatic Cancer Orthotopic Mouse Model: An Opposite Effect of Chemotherapy.
    Anticancer research, 2019, Volume: 39, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Green Fluorescent Proteins; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Pancreas; Pancreatic Neoplasms

2019
Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine.
    Carcinogenesis, 2020, 07-14, Volume: 41, Issue:7

    Topics: Abnormalities, Multiple; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Keratoconus; Mice; Organophosphates; Pancreatic Neoplasms; Signal Transduction; Valproic Acid; Xenograft Model Antitumor Assays

2020
A Study Comparing the Effects of Targeted Intra-Arterial and Systemic Chemotherapy in an Orthotopic Mouse Model of Pancreatic Cancer.
    Scientific reports, 2019, 11-04, Volume: 9, Issue:1

    Topics: Administration, Intravenous; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intra-Arterial; Male; Mice; Mice, Nude; Neoplasm, Residual; Pancreatic Neoplasms; Transplantation, Heterologous

2019
Novel Mechanistic Insight into the Anticancer Activity of Cucurbitacin D against Pancreatic Cancer (Cuc D Attenuates Pancreatic Cancer).
    Cells, 2019, Dec-31, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation; Humans; Mice; Models, Molecular; Mucins; Pancreatic Neoplasms; Structure-Activity Relationship; Triterpenes; Xenograft Model Antitumor Assays

2019
Runx2 Deficiency in Osteoblasts Promotes Myeloma Progression by Altering the Bone Microenvironment at New Bone Sites.
    Cancer research, 2020, 03-01, Volume: 80, Issue:5

    Topics: Animals; Bone and Bones; Bone Marrow; Bone Neoplasms; Cell Line, Tumor; Core Binding Factor Alpha 1 Subunit; Deoxycytidine; Disease Models, Animal; Female; Fluorouracil; Gemcitabine; Humans; Male; Mice; Mice, Knockout; Multiple Myeloma; Myeloid-Derived Suppressor Cells; Osteoblasts; Tumor Microenvironment

2020
Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
    Molecular cancer research : MCR, 2020, Volume: 18, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Dasatinib; Deoxycytidine; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Protein Kinase Inhibitors; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Stromal Cells; Survival Analysis; Xenograft Model Antitumor Assays

2020
Quantification of fluorophore distribution and therapeutic response in matched in vivo and ex vivo pancreatic cancer model systems.
    PloS one, 2020, Volume: 15, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Female; Fluorescent Dyes; Gemcitabine; Humans; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Middle Aged; Organoids; Pancreatic Neoplasms; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
Comparing the intra-tumoral distribution of Gemcitabine, 5-Fluorouracil, and Capecitabine in a murine model of pancreatic ductal adenocarcinoma.
    PloS one, 2020, Volume: 15, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Deoxycytidine; Diagnostic Techniques, Radioisotope; Disease Models, Animal; Fluorouracil; Gemcitabine; Mice; Mice, Inbred C57BL; Organoids; Pancreatic Neoplasms

2020
Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia.
    Leukemia, 2020, Volume: 34, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Management; Disease Models, Animal; Drug Evaluation, Preclinical; Gemcitabine; Gene Rearrangement; Genetic Predisposition to Disease; Humans; Infant; Myeloid-Lymphoid Leukemia Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Enhanced Efficacy of Combination of Gemcitabine and Phosphatidylserine-Targeted Nanovesicles against Pancreatic Cancer.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2020, 08-05, Volume: 28, Issue:8

    Topics: Animals; Antineoplastic Agents; Biomarkers; Cell Cycle; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Flow Cytometry; Gemcitabine; Gene Expression; Humans; Mice; Nanoparticles; Pancreatic Neoplasms; Phosphatidylserines; Xenograft Model Antitumor Assays

2020
Gemcitabine and checkpoint blockade exhibit synergistic anti-tumor effects in a model of murine lung carcinoma.
    International immunopharmacology, 2020, Volume: 86

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; B7-H1 Antigen; Carcinoma, Lewis Lung; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Synergism; Gemcitabine; Immune Checkpoint Inhibitors; Lymphocytes, Tumor-Infiltrating; Mice, Inbred C57BL; Neoplasm Recurrence, Local; Programmed Cell Death 1 Receptor; Tumor Microenvironment; Up-Regulation

2020
Pressure-enabled delivery of gemcitabine in an orthotopic pancreatic cancer mouse model.
    Surgery, 2020, Volume: 168, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Infusions, Intralesional; Infusions, Intravenous; Male; Mice; Pancreas; Pancreatic Neoplasms; Pressure; Tissue Distribution

2020
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
    Molecular cancer, 2020, 07-29, Volume: 19, Issue:1

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Autophagy; Autophagy-Related Proteins; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Mice; MicroRNAs; Pancreatic Neoplasms; Protein Binding; RNA Interference; RNA, Long Noncoding; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2020
Bitter melon juice intake with gemcitabine intervention circumvents resistance to gemcitabine in pancreatic patient-derived xenograft tumors.
    Molecular carcinogenesis, 2020, Volume: 59, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Humans; Mice; Mice, Nude; Momordica charantia; Neoplasm Invasiveness; Pancreatic Neoplasms; Plant Extracts; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy.
    Anticancer research, 2020, Volume: 40, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Fluorouracil; Gemcitabine; Humans; Liver Neoplasms; Mice; Oxaliplatin; Stomach; Stomach Neoplasms; Xenograft Model Antitumor Assays

2020
Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice.
    Journal for immunotherapy of cancer, 2020, Volume: 8, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Immunomodulation; Mice; Niacinamide; Vitamin B Complex

2020
Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis.
    Journal for immunotherapy of cancer, 2020, Volume: 8, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Immune Checkpoint Inhibitors; Liver Neoplasms; Macrophages; Mice; Neoplasm Metastasis; Pancreatic Neoplasms; Tumor Microenvironment

2020
EMT-Induced Gemcitabine Resistance in Pancreatic Cancer Involves the Functional Loss of Equilibrative Nucleoside Transporter 1.
    Molecular cancer therapeutics, 2021, Volume: 20, Issue:2

    Topics: Animals; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Epithelial-Mesenchymal Transition; Equilibrative Nucleoside Transporter 1; Gemcitabine; Humans; Mice

2021
Evaluation of Loading Strategies to Improve Tumor Uptake of Gemcitabine in a Murine Orthotopic Bladder Cancer Model Using Ultrasound and Microbubbles.
    Ultrasound in medicine & biology, 2021, Volume: 47, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Disease Models, Animal; Drug Delivery Systems; Female; Gemcitabine; Mice; Mice, Nude; Microbubbles; Tumor Cells, Cultured; Ultrasonic Therapy; Urinary Bladder Neoplasms

2021
Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma.
    Scientific reports, 2021, 07-07, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Agents; Axitinib; Cell Line, Tumor; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Gene Amplification; Gene Expression; Humans; Medulloblastoma; Mice; Neovascularization, Pathologic; Proto-Oncogene Proteins c-myc; Receptors, Vascular Endothelial Growth Factor; Treatment Outcome; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2021
Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2.
    Molecular cancer, 2017, 03-21, Volume: 16, Issue:1

    Topics: Angiogenic Proteins; Animals; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Mice; Pancreatic Neoplasms; Prognosis; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Ribonucleoside Diphosphate Reductase; Transcriptional Activation; Xenograft Model Antitumor Assays

2017
Tumor regression is mediated via the induction of HER263-71- specific CD8+ CTL activity in a 4T1.2/HER2 tumor model: no involvement of CD80 in tumor control.
    Oncotarget, 2017, Apr-18, Volume: 8, Issue:16

    Topics: Animals; Antigens, Neoplasm; Biomarkers; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Immunoglobulin G; Interferon-gamma; Mice; Mice, Knockout; Neoplasms; Receptor, ErbB-2; T-Cell Antigen Receptor Specificity; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Th1 Cells; Tumor Burden

2017
MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX).
    Oncotarget, 2017, Jul-18, Volume: 8, Issue:29

    Topics: Animals; Antineoplastic Agents; Azetidines; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gemcitabine; Humans; Mice; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Xenograft Model Antitumor Assays

2017
Establishment of patient-derived tumor xenograft (PDTX) models using samples from CT-guided percutaneous biopsy.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017, May-18, Volume: 50, Issue:6

    Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Deoxycytidine; Disease Models, Animal; Feasibility Studies; Female; Gemcitabine; Humans; Image-Guided Biopsy; Liver Neoplasms; Lung Neoplasms; Male; Mice, Inbred Strains; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Tomography, X-Ray Computed; Xenograft Model Antitumor Assays

2017
Antiviral activity of gemcitabine against human rhinovirus in vitro and in vivo.
    Antiviral research, 2017, Volume: 145

    Topics: Animals; Antiviral Agents; Cytokines; Deoxycytidine; Disease Models, Animal; Drug Repositioning; Gemcitabine; Humans; Inflammation; Lung; Mice; Picornaviridae Infections; Rhinovirus; RNA, Viral; Viral Load; Virus Replication

2017
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
    Theranostics, 2017, Volume: 7, Issue:12

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance; Gemcitabine; Humans; Kruppel-Like Factor 4; Male; Mice, Nude; MicroRNAs; Neoplastic Stem Cells; Nuclear Factor 90 Proteins; RNA, Long Noncoding; Signal Transduction; Transforming Growth Factor beta1; Urinary Bladder Neoplasms

2017
Cytolytic virus activation therapy and treatment monitoring for Epstein-Barr virus associated nasopharyngeal carcinoma in a mouse tumor model.
    Journal of medical virology, 2017, Volume: 89, Issue:12

    Topics: Animals; Antiviral Agents; Carcinoma; Deoxycytidine; Disease Models, Animal; DNA, Viral; Epstein-Barr Virus Infections; Ganciclovir; Gemcitabine; Herpesvirus 4, Human; Humans; Mice; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Treatment Outcome; Tumor Cells, Cultured; Valproic Acid; Viral Load; Virus Activation

2017
Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment.
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:11

    Topics: Adenocarcinoma; Animals; Benzamides; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Hepatocyte Growth Factor; Humans; Imidazoles; Mice; Mice, Transgenic; Neoplasm Metastasis; Proto-Oncogene Proteins c-met; Pyridines; Triazines; Tumor Microenvironment

2017
MiR-10a-5p targets TFAP2C to promote gemcitabine resistance in pancreatic ductal adenocarcinoma.
    Journal of experimental & clinical cancer research : CR, 2018, Apr-03, Volume: 37, Issue:1

    Topics: Aged; Aged, 80 and over; Animals; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Glycoproteins; Mice; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Receptors, Immunologic; RNA Interference; Transcription Factor AP-2; Xenograft Model Antitumor Assays

2018
MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model.
    Tissue & cell, 2018, Volume: 52

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Pyridones; Pyrimidinones; Xenograft Model Antitumor Assays

2018
Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway.
    Theranostics, 2018, Volume: 8, Issue:12

    Topics: Aged; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression Profiling; Heterografts; Humans; Male; Mice, Inbred BALB C; Middle Aged; Neoplasm Transplantation; NF-kappa B; Pancreatic Neoplasms; Real-Time Polymerase Chain Reaction; Signal Transduction; Tripartite Motif Proteins; Tumor Cells, Cultured; Ubiquitin-Protein Ligases

2018
Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma.
    Cancer research, 2018, 09-15, Volume: 78, Issue:18

    Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Exosomes; Gemcitabine; Gene Transfer Techniques; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Pancreatic Neoplasms; rab27 GTP-Binding Proteins; Tumor Microenvironment; Up-Regulation

2018
Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer.
    Life sciences, 2018, Sep-01, Volume: 208

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Female; Gemcitabine; Homeodomain Proteins; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Knockout; Mutation; Neovascularization, Pathologic; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Trans-Activators; Tumor Microenvironment; Tumor Suppressor Protein p53

2018
Gemcitabine Synergizes with Immune Checkpoint Inhibitors and Overcomes Resistance in a Preclinical Model and Mesothelioma Patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 12-15, Volume: 24, Issue:24

    Topics: Animals; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Biomarkers, Tumor; Biopsy; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Gene Expression; Humans; Immunomodulation; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Positron Emission Tomography Computed Tomography; Prognosis; Treatment Outcome; Xenograft Model Antitumor Assays

2018
Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with
    International journal of molecular sciences, 2018, Sep-29, Volume: 19, Issue:10

    Topics: Animals; Antibodies, Monoclonal; Basigin; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Radioimmunotherapy; Yttrium Radioisotopes

2018
Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties.
    Molecules (Basel, Switzerland), 2018, Oct-11, Volume: 23, Issue:10

    Topics: Amino Acids; Animals; Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Chromatography, Liquid; Chromatography, Thin Layer; Deoxycytidine; Disease Models, Animal; Drug Monitoring; Drug Stability; Gemcitabine; Humans; Magnetic Resonance Spectroscopy; Pancreatic Neoplasms; Prodrugs; Tandem Mass Spectrometry; Threonine; Xenograft Model Antitumor Assays

2018
Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma.
    Science translational medicine, 2018, 10-24, Volume: 10, Issue:464

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antibodies, Neutralizing; Autocrine Communication; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Chemokines; Deoxycytidine; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Gemcitabine; Gene Silencing; Humans; Immunotherapy; Intercellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Nude; Neutralization Tests; NF-kappa B; Pancreatic Neoplasms; Pancreatic Stellate Cells; Paracrine Communication; Survival Analysis

2018
Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
    Redox biology, 2019, Volume: 20

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Proliferation; Delta-5 Fatty Acid Desaturase; Deoxycytidine; Disease Models, Animal; Drug Synergism; Fatty Acid Desaturases; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Metastasis; Neoplasm Staging; Pancreatic Neoplasms; RNA Interference; RNA, Small Interfering; Xenograft Model Antitumor Assays

2019
The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 111

    Topics: Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Mice; Mice, Nude; Middle Aged; Paclitaxel; Sarcoma; Treatment Outcome; Xenograft Model Antitumor Assays

2019
Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models.
    Cancer science, 2019, Volume: 110, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Interferon Type I; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Myeloid Cells; Pancreatic Neoplasms; Transcriptome; Xenograft Model Antitumor Assays

2019
Enhanced anti-tumor efficiency of gemcitabine prodrug by FAPα-mediated activation.
    International journal of pharmaceutics, 2019, Mar-25, Volume: 559

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Endopeptidases; Gelatinases; Gemcitabine; Humans; Lung Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; PC-3 Cells; Prodrugs; Rats, Sprague-Dawley; Serine Endopeptidases; Tumor Microenvironment

2019
Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.
    EBioMedicine, 2019, Volume: 40

    Topics: 5'-Nucleotidase; Animals; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression; Humans; Mice; Mice, Transgenic; Models, Biological; Pancreatic Neoplasms; Prognosis; Xenograft Model Antitumor Assays

2019
Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway.
    Redox biology, 2019, Volume: 22

    Topics: Animals; Apoptosis; Cell Line, Tumor; Deoxycytidine; Digoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Gene Expression Profiling; Germ Cells; Humans; Mice; Models, Biological; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcriptome; Xenograft Model Antitumor Assays

2019
aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.
    Redox biology, 2019, Volume: 22

    Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Transformation, Neoplastic; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gallbladder Neoplasms; Gemcitabine; Gene Knockdown Techniques; Humans; Kelch-Like ECH-Associated Protein 1; Mice; Models, Biological; NF-E2-Related Factor 2; Prognosis; Protein Binding; Protein Interaction Domains and Motifs; Protein Kinase C; Reactive Oxygen Species; Signal Transduction

2019
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019, Volume: 60, Issue:10

    Topics: Animals; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Copper Radioisotopes; Deoxycytidine; Disease Models, Animal; ErbB Receptors; Female; Gemcitabine; HCT116 Cells; Humans; Injections, Intraperitoneal; Liver Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Transplantation; Pancreatic Neoplasms; Radioimmunotherapy; Radiotherapy, Adjuvant; Treatment Outcome

2019
RNAi-Mediated PD-L1 Inhibition for Pancreatic Cancer Immunotherapy.
    Scientific reports, 2019, 03-18, Volume: 9, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; B7-H1 Antigen; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Drug Monitoring; Female; Gemcitabine; Humans; Immunotherapy; Magnetic Resonance Imaging; Magnetite Nanoparticles; Maximum Tolerated Dose; Mice; Pancreas; Pancreatic Neoplasms; RNA Interference; RNA, Small Interfering; Tumor Microenvironment

2019
Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC.
    International journal of molecular sciences, 2019, May-16, Volume: 20, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Deoxycytidine; Disease Models, Animal; Fendiline; Gemcitabine; Humans; Inhibitory Concentration 50; Mice; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphoproteins; Proto-Oncogene Proteins c-met; Pyrrolidinones; Quinolines; Signal Transduction; Verteporfin; YAP-Signaling Proteins

2019
HNF1A inhibition induces the resistance of pancreatic cancer cells to gemcitabine by targeting ABCB1.
    EBioMedicine, 2019, Volume: 44

    Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression; Hepatocyte Nuclear Factor 1-alpha; Humans; Immunohistochemistry; Male; Mice; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Pancreatic Neoplasms; Prognosis; Promoter Regions, Genetic; Protein Binding

2019
Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 08-15, Volume: 25, Issue:16

    Topics: Animals; Arginine; Argininosuccinate Synthase; Cell Line, Tumor; Cell Membrane; Deoxycytidine; Disease Models, Animal; Docetaxel; Equilibrative Nucleoside Transporter 1; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Models, Biological; Neoplasms; Protein Binding; Protein Transport; Proto-Oncogene Proteins c-myc; Xenograft Model Antitumor Assays

2019
Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 09-15, Volume: 25, Issue:18

    Topics: Albumins; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Cycle Checkpoints; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gemcitabine; Humans; Immunohistochemistry; Mice; Microtubules; Paclitaxel; Pancreatic Neoplasms; Protein Multimerization; Tubulin Modulators; Xenograft Model Antitumor Assays

2019
The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 117

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Docetaxel; Doxorubicin; Drug Resistance, Neoplasm; Gemcitabine; Heterografts; Humans; Indazoles; Liposarcoma; Male; Mice; Mice, Nude; Neoplasm Recurrence, Local; Pyrimidines; Sulfonamides; Tumor Burden; Xenograft Model Antitumor Assays

2019
p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 07-16, Volume: 116, Issue:29

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinogenesis; Carcinoma, Pancreatic Ductal; Class Ia Phosphatidylinositol 3-Kinase; Class Ib Phosphatidylinositol 3-Kinase; Deoxycytidine; Diet, High-Fat; Disease Models, Animal; Drug Resistance, Neoplasm; Fatty Acids, Omega-6; Female; Gemcitabine; Glucose; Humans; Lipid Metabolism; Liver; Male; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity; Pancreas; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Signal Transduction; Up-Regulation

2019
FF-10832 enables long survival via effective gemcitabine accumulation in a lethal murine peritoneal dissemination model.
    Cancer science, 2019, Volume: 110, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Ascites; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Stability; Female; Gemcitabine; Humans; Injections, Intravenous; Kaplan-Meier Estimate; Liposomes; Mice; Mice, Inbred BALB C; Peritoneal Neoplasms; Peritoneum; Tissue Distribution; Treatment Outcome

2019
Inhibiting the growth of pancreatic adenocarcinoma in vitro and in vivo through targeted treatment with designer gold nanotherapeutics.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Fluids; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Designer Drugs; Disease Models, Animal; Gemcitabine; Gold; Humans; Immunohistochemistry; Light; Male; Metal Nanoparticles; Mice; Mice, Nude; Molecular Targeted Therapy; Nanoconjugates; Pancreatic Neoplasms; Scattering, Radiation; Static Electricity; Treatment Outcome

2013
Antibody targeting of CD24 efficiently retards growth and influences cytokine milieu in experimental carcinomas.
    British journal of cancer, 2013, Apr-16, Volume: 108, Issue:7

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ovarian Epithelial; CD24 Antigen; Cell Growth Processes; Cell Line, Tumor; Cell Proliferation; Cytokines; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Immunohistochemistry; Lung Neoplasms; Macrophages; Mice; Mice, SCID; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2013
Preclinical analyses of intravesical chemotherapy for prevention of bladder cancer progression.
    Oncotarget, 2013, Volume: 4, Issue:2

    Topics: Administration, Intravesical; Animals; Antineoplastic Agents; Cycloleucine; Deoxycytidine; Disease Models, Animal; Disease Progression; Docetaxel; Drug Screening Assays, Antitumor; Female; Gemcitabine; Mice; Mice, Inbred C57BL; Random Allocation; Taxoids; Treatment Outcome; Urinary Bladder Neoplasms

2013
Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer.
    BMC cancer, 2013, Apr-17, Volume: 13

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cytokines; Deoxycytidine; Disease Models, Animal; Gemcitabine; Immunohistochemistry; Mice; Mice, Mutant Strains; NF-kappa B; Pancreatic Neoplasms; Sesquiterpenes

2013
Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma.
    Cancer immunology, immunotherapy : CII, 2013, Volume: 62, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow Cells; Carcinoma; Cell Line, Tumor; Combined Modality Therapy; Dendritic Cells; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Immunotherapy, Adoptive; Mice; Pancreatic Neoplasms; T-Lymphocytes, Regulatory; Tumor Burden

2013
Adjuvant gemcitabine therapy improves survival in a locally induced, R0-resectable model of metastatic intrahepatic cholangiocarcinoma.
    Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Chemotherapy, Adjuvant; Cholangiocarcinoma; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Gemcitabine; Hepatectomy; Mice; Mice, Inbred Strains; Mice, Knockout; Neoplasm Recurrence, Local; Proto-Oncogene Proteins p21(ras); Risk Factors; Survival Rate; Tumor Suppressor Protein p53

2013
A bioengineered metastatic pancreatic tumor model for mechanistic investigation of chemotherapeutic drugs.
    Journal of biotechnology, 2013, Jul-20, Volume: 166, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bioengineering; Camptothecin; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Fluorouracil; Gemcitabine; Humans; Leucovorin; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Organoplatinum Compounds; Pancreatic Neoplasms; Tissue Scaffolds; Xenograft Model Antitumor Assays

2013
Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2013, Volume: 21, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genetic Therapy; Humans; Lung Neoplasms; Mice; Nanoparticles; Neovascularization, Pathologic; RNA, Small Interfering; Tumor Burden; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2013
Comparative benefits of Nab-paclitaxel over gemcitabine or polysorbate-based docetaxel in experimental pancreatic cancer.
    Carcinogenesis, 2013, Volume: 34, Issue:10

    Topics: Albumin-Bound Paclitaxel; Albumins; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Docetaxel; Female; Gemcitabine; Humans; Inhibitory Concentration 50; Neoplasms, Experimental; Paclitaxel; Pancreatic Neoplasms; Stathmin; Stromal Cells; Taxoids; Tubulin; Tumor Burden; Xenograft Model Antitumor Assays

2013
Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Aug-15, Volume: 19, Issue:16

    Topics: Animals; Cell Line, Tumor; Checkpoint Kinase 1; Chemoradiotherapy; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Humans; Inhibitory Concentration 50; Mice; Pancreatic Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Pyrazoles; Pyrimidines; Radiation-Sensitizing Agents; Recombinational DNA Repair; Xenograft Model Antitumor Assays

2013
Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Disease Models, Animal; Drug Screening Assays, Antitumor; Fluorouracil; Gemcitabine; Mice; Mice, Transgenic; Neoplasm Transplantation; Pancreatic Neoplasms; Prodrugs; Tissue Distribution

2013
Combination therapy of VEGF-trap and gemcitabine results in improved anti-tumor efficacy in a mouse lung cancer model.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Gene Expression; Genes, Reporter; Lung Neoplasms; Mice; Neovascularization, Pathologic; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Tumor Burden

2013
Stromal disrupting effects of nab-paclitaxel in pancreatic cancer.
    British journal of cancer, 2013, Aug-20, Volume: 109, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Collagen; Deoxycytidine; Disease Models, Animal; Elasticity Imaging Techniques; Endosonography; Female; Fibroblasts; Gemcitabine; Humans; Male; Mice; Middle Aged; Neoadjuvant Therapy; Paclitaxel; Pancreatic Neoplasms; Positron-Emission Tomography

2013
Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:10

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Body Weight; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Deoxycytidine; Disease Models, Animal; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Epithelial-Mesenchymal Transition; Female; Gemcitabine; Genes, ras; Genotype; Immunohistochemistry; Male; Mice; Mice, Transgenic; Pancreatic Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Poly(ADP-ribose) Polymerases; Random Allocation; Signal Transduction; Treatment Outcome; Vitamin E

2013
Aspirin prolongs survival and reduces the number of Foxp3+ regulatory T cells in a genetically engineered mouse model of pancreatic cancer.
    Langenbeck's archives of surgery, 2013, Volume: 398, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Aspirin; Carcinoma, Pancreatic Ductal; Cyclooxygenase Inhibitors; Deoxycytidine; Disease Models, Animal; Drug Therapy, Combination; Forkhead Transcription Factors; Gemcitabine; Mice; Mice, Transgenic; Pancreatic Neoplasms; T-Lymphocytes, Regulatory

2013
Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase.
    Oncogene, 2014, Jul-17, Volume: 33, Issue:29

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gemcitabine; Humans; Macrophages; Mice; Mice, Knockout; Pancreatic Neoplasms; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Xenograft Model Antitumor Assays

2014
Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.
    Gut, 2014, Volume: 63, Issue:6

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cadherins; Carcinogenesis; Caspase 3; Cell Survival; Claudin-1; Cyclin-Dependent Kinase Inhibitor p16; Deoxycytidine; Disease Models, Animal; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Gemcitabine; Gene Expression; Genes, Suppressor; Heterozygote; Immediate-Early Proteins; Life Expectancy; Mice; Mice, Knockout; Mucin-1; Neoplasm Proteins; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Signal Transduction; Transforming Growth Factor beta1; Tumor Cells, Cultured

2014
Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:12

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cellular Senescence; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Humans; Mice; Neoplasm Grading; Neoplasm Metastasis; Neovascularization, Pathologic; Pancreatic Neoplasms; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-raf; Retinoblastoma Protein; Tumor Burden; Xenograft Model Antitumor Assays

2013
Schedule-dependent therapeutic efficacy of L19mTNF-α and melphalan combined with gemcitabine.
    Cancer medicine, 2013, Volume: 2, Issue:4

    Topics: Adoptive Transfer; Animals; Antineoplastic Combined Chemotherapy Protocols; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Gemcitabine; Immunologic Memory; Lymphocyte Depletion; Lymphocytes, Tumor-Infiltrating; Melphalan; Mice; Myeloid Cells; Neoplasms; Recombinant Fusion Proteins; T-Lymphocytes, Regulatory

2013
Reduction of decoy receptor 3 enhances TRAIL-mediated apoptosis in pancreatic cancer.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Pancreatic Neoplasms; Protein Binding; Receptors, Tumor Necrosis Factor, Member 6b; RNA Interference; TNF-Related Apoptosis-Inducing Ligand; Tumor Burden; Tumor Necrosis Factor Ligand Superfamily Member 14; Xenograft Model Antitumor Assays

2013
Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer.
    BioMed research international, 2013, Volume: 2013

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Mice; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Pancreatic Neoplasms

2013
Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Adenoviridae; Animals; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Line, Tumor; Chemokines; Deoxycytidine; Disease Models, Animal; Drug Synergism; Gemcitabine; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genetic Therapy; Genetic Vectors; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms

2014
DUSP1 is a novel target for enhancing pancreatic cancer cell sensitivity to gemcitabine.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cisplatin; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Dual Specificity Phosphatase 1; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mice; Neovascularization, Pathologic; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Signal Transduction; Transcription, Genetic; Xenograft Model Antitumor Assays

2014
Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX).
    Journal of cellular biochemistry, 2014, Volume: 115, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Cisplatin; Deoxycytidine; Disease Models, Animal; Fluorouracil; Gemcitabine; Humans; Luminescent Proteins; Mice; Mice, Nude; Mice, SCID; Pancreatic Neoplasms; Red Fluorescent Protein; Salmonella Infections; Salmonella typhimurium; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2014
Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance.
    International journal of cancer, 2014, Nov-15, Volume: 135, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Movement; Cell Proliferation; Cell Survival; Deoxycytidine; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Gemcitabine; Humans; Immunoenzyme Techniques; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Pancreatic Neoplasms; Prognosis; Receptor, PAR-1; Signal Transduction; Stromal Cells; Tumor Cells, Cultured

2014
Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer.
    European journal of cancer (Oxford, England : 1990), 2014, Volume: 50, Issue:7

    Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Synergism; Gemcitabine; Glycosides; Mice; Mice, Nude; Pancreatic Neoplasms; Triterpenes

2014
Anticancer effects of gemcitabine are enhanced by co-administered iRGD peptide in murine pancreatic cancer models that overexpressed neuropilin-1.
    British journal of cancer, 2014, Mar-18, Volume: 110, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Synergism; Female; Gemcitabine; Humans; Male; Mice; Middle Aged; Neuropilin-1; Oligopeptides; Pancreatic Neoplasms; Xenograft Model Antitumor Assays

2014
Gemcitabine chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer.
    Oral oncology, 2014, Volume: 50, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Deoxycytidine; Disease Models, Animal; Gemcitabine; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred C3H; Mouth Neoplasms; Phenotype; T-Lymphocytes

2014
Gemcitabine as a molecular targeting agent that blocks the Akt cascade in platinum-resistant ovarian cancer.
    Journal of ovarian research, 2014, Apr-09, Volume: 7

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cisplatin; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Ovarian Neoplasms; Platinum; Proto-Oncogene Proteins c-akt; Signal Transduction; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2014
Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer.
    Neoplasia (New York, N.Y.), 2014, Volume: 16, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Transformation, Neoplastic; Cytokines; Deoxycytidine; Disease Models, Animal; Gemcitabine; Genes, p53; Genes, ras; Homeodomain Proteins; Mice; Mice, Transgenic; NF-kappa B; Pancreatic Neoplasms; Pancreatitis, Chronic; Phosphorylation; STAT3 Transcription Factor; Systemic Inflammatory Response Syndrome; Trans-Activators; Treatment Outcome

2014
Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy.
    Neoplasia (New York, N.Y.), 2014, Volume: 16, Issue:6

    Topics: Adenocarcinoma; Administration, Metronomic; Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Movement; Deoxycytidine; Disease Models, Animal; Female; Gastrointestinal Hormones; Gemcitabine; Humans; Mice; Neoplasm Metastasis; Neuropeptides; Pancreatic Neoplasms; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays

2014
Monitoring oxygen levels in orthotopic human glioma xenograft following carbogen inhalation and chemotherapy by implantable resonator-based oximetry.
    International journal of cancer, 2015, Apr-01, Volume: 136, Issue:7

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carbon Dioxide; Cell Cycle; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Glioma; Humans; Hypoxia; Inhalation; Magnetic Resonance Imaging; Male; Mice; Oximetry; Oxygen; Oxygen Consumption; Pyrazoles; Pyrimidines; Xenograft Model Antitumor Assays

2015
Hyperthermia inhibits recombination repair of gemcitabine-stalled replication forks.
    Journal of the National Cancer Institute, 2014, Volume: 106, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; Deoxycytidine; Disease Models, Animal; DNA Replication; DNA-Binding Proteins; DNA, Neoplasm; Drug Resistance, Neoplasm; Exonucleases; Gemcitabine; Humans; Hyperthermia, Induced; Liver Neoplasms; Mice; Mice, SCID; MRE11 Homologue Protein; Neoplasms, Experimental; Radio Waves; Radiofrequency Therapy; Recombinational DNA Repair

2014
Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling.
    BMC cancer, 2014, Sep-20, Volume: 14

    Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Argininosuccinate Synthase; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Transformation, Neoplastic; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression; Humans; Hydrolases; Male; Mice; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; NF-kappa B; Pancreatic Neoplasms; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT3 Transcription Factor; Tumor Burden; Xenograft Model Antitumor Assays

2014
Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.
    Oncotarget, 2014, Nov-30, Volume: 5, Issue:22

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazoles; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Female; Gemcitabine; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Pancreatic Neoplasms; Signal Transduction; Xenograft Model Antitumor Assays

2014
Acute and delayed toxicity of gemcitabine administered during isolated lung perfusion: a preclinical dose-escalation study in pigs.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2015, Volume: 48, Issue:2

    Topics: Acute Disease; Acute Lung Injury; Anesthesia, General; Animals; Antimetabolites, Antineoplastic; Chemotherapy, Cancer, Regional Perfusion; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Gemcitabine; Lung; Lung Neoplasms; Sus scrofa

2015
Targeted oncolytic herpes simplex virus type 1 eradicates experimental pancreatic tumors.
    Human gene therapy, 2015, Volume: 26, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Cycle Proteins; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Gene Expression Regulation; Genetic Engineering; Herpesvirus 1, Human; Humans; Injections, Intralesional; Mice; Mice, Nude; Neoplasm Transplantation; Oncolytic Virotherapy; Pancreas; Pancreatic Neoplasms; Promoter Regions, Genetic; Trans-Activators; Tumor Burden; Viral Proteins

2015
A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.
    Anticancer research, 2014, Volume: 34, Issue:12

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cytidine; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Nude; Neoplasms; Xenograft Model Antitumor Assays

2014
Local iontophoretic administration of cytotoxic therapies to solid tumors.
    Science translational medicine, 2015, Feb-04, Volume: 7, Issue:273

    Topics: Animals; Antineoplastic Agents; Cell Death; Cell Proliferation; Cisplatin; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Dogs; Drug Delivery Systems; Equipment Design; Female; Gemcitabine; Humans; Injections, Intravenous; Iontophoresis; Mice, Inbred BALB C; Neoplasms; Skin; Survival Analysis; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays

2015
Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer.
    Biomaterials, 2015, Volume: 46

    Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Delivery Systems; Endocytosis; Female; Gemcitabine; Gene Knockdown Techniques; Gene Transfer Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interferon-alpha; Interleukin-6; Kaplan-Meier Estimate; Lipids; Lysosomes; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Pancreatic Neoplasms; Particle Size; Polymers; RNA, Small Interfering; Serum; Static Electricity

2015
Proapoptotic and antiapoptotic proteins of the Bcl-2 family regulate sensitivity of pancreatic cancer cells toward gemcitabine and T-cell-mediated cytotoxicity.
    Journal of immunotherapy (Hagerstown, Md. : 1997), 2015, Volume: 38, Issue:3

    Topics: Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Cancer Vaccines; Cell Line, Tumor; Cytotoxicity, Immunologic; Dendritic Cells; Deoxycytidine; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; fas Receptor; Female; Gemcitabine; Gene Expression; Gene Silencing; Humans; Immunotherapy; Mice; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; RNA Interference; T-Lymphocyte Subsets; Tumor Burden; Xenograft Model Antitumor Assays

2015
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance.
    EMBO molecular medicine, 2015, Volume: 7, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Cycle Proteins; Cells, Cultured; Deoxycytidine; Disease Models, Animal; Drug Resistance; Fibroblasts; Gemcitabine; Heterografts; Humans; Mice, Nude; Phosphoproteins; Somatostatin; TOR Serine-Threonine Kinases; Treatment Outcome

2015
SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
    European journal of pharmacology, 2015, Jun-15, Volume: 757

    Topics: Animals; Apoptosis; Carbazoles; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Deoxycytidine; Disease Models, Animal; Drug Synergism; Epithelial-Mesenchymal Transition; Gemcitabine; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Male; Mice; Micronucleus Tests; Pancreatic Neoplasms; Sirtuin 1

2015
Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages.
    Gastroenterology, 2015, Volume: 149, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; CD40 Antigens; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Immunohistochemistry; Immunotherapy; Macrophages; Mice; Pancreatic Neoplasms

2015
Distribution of Gemcitabine Is Nearly Homogenous in Two Orthotopic Murine Models of Pancreatic Cancer.
    Cancer biotherapy & radiopharmaceuticals, 2015, Volume: 30, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Xenograft Model Antitumor Assays

2015
AduPARE1A and gemcitabine combined treatment trigger synergistic antitumor effects in pancreatic cancer through NF-κB mediated uPAR activation.
    Molecular cancer, 2015, Jul-31, Volume: 14

    Topics: Adenoviridae; Animals; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Humans; Male; Mice; NF-kappa B; Oncolytic Virotherapy; Oncolytic Viruses; Pancreatic Neoplasms; Receptors, Urokinase Plasminogen Activator; Virus Replication; Xenograft Model Antitumor Assays

2015
The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1).
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Dec-15, Volume: 21, Issue:24

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Female; Gemcitabine; Gene Knockdown Techniques; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Niacinamide; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Ribonucleoside Diphosphate Reductase; RNA, Small Interfering; Transplantation, Isogeneic; Tumor Burden; Tumor Suppressor Proteins; Ubiquitination

2015
Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Animals; Antineoplastic Agents; Deoxycytidine; Disease Models, Animal; Gemcitabine; Indazoles; Mice; Mice, Nude; Pyrimidines; Salmonella Infections; Salmonella typhimurium; Sarcoma; Soft Tissue Neoplasms; Sulfonamides; Xenograft Model Antitumor Assays

2015
Semi-Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for the Combination Use of Dexamethasone and Gemcitabine in Breast Cancer.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:12

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Deoxycytidine; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Gemcitabine; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Xenograft Model Antitumor Assays

2015
Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer.
    Cancer research, 2015, Nov-01, Volume: 75, Issue:21

    Topics: AC133 Antigen; Animals; Antigens, CD; Antigens, Ly; Antimetabolites, Antineoplastic; Biomarkers, Tumor; CD24 Antigen; Cell Transformation, Neoplastic; Deoxycytidine; Disease Models, Animal; Gemcitabine; Glycoproteins; Luciferases; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Neoplastic Stem Cells; Pancreas; Pancreatic Neoplasms; Peptides; Phenotype; Proto-Oncogene Proteins p21(ras); Pyrans; Spheroids, Cellular; Staining and Labeling; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2015
Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling.
    Scientific reports, 2015, Sep-22, Volume: 5

    Topics: AC133 Antigen; Animals; Antigens, CD; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Gemcitabine; Gene Knockdown Techniques; Glycoproteins; Humans; Metformin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplastic Stem Cells; Pancreatic Neoplasms; Peptides; Phosphorylation; Prognosis; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Xenograft Model Antitumor Assays

2015
IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Mar-15, Volume: 22, Issue:6

    Topics: Animals; Antineoplastic Agents; Autocrine Communication; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Deoxycytidine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gemcitabine; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Male; Mice; NF-kappa B; Pancreatic Neoplasms; Receptors, Interleukin-1; Xenograft Model Antitumor Assays

2016
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.
    Nature, 2015, Nov-26, Volume: 527, Issue:7579

    Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Gemcitabine; Male; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Nucleoside Transport Proteins; Pancreatic Neoplasms; Snail Family Transcription Factors; Survival Analysis; Transcription Factors; Twist-Related Protein 1

2015
EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer.
    Biomacromolecules, 2016, Jan-11, Volume: 17, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Carriers; ErbB Receptors; Gemcitabine; Humans; Mice; Micelles; Pancreatic Neoplasms; Peptides; Polyesters; Polyethylene Glycols; Polymers

2016
Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice.
    Genetics and molecular research : GMR, 2015, Dec-02, Volume: 14, Issue:4

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Gene Expression; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Tumor Burden; Xenograft Model Antitumor Assays

2015
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Apr-01, Volume: 22, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Hepatocyte Growth Factor; Humans; Inhibitor of Differentiation Protein 1; Mice; Neoplasm Metastasis; Nicotine; Pancreatic Neoplasms; Paracrine Communication; Phosphorylation; Proto-Oncogene Proteins c-met; Signal Transduction; Smoking; Tumor Microenvironment; Xenograft Model Antitumor Assays

2016
Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2', 2'-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity.
    Neoplasia (New York, N.Y.), 2016, Volume: 18, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Survival; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Stability; Female; Gemcitabine; Humans; Mice; Mice, Transgenic; Solubility; X-Ray Diffraction; Xenograft Model Antitumor Assays

2016
SPARC-Independent Delivery of Nab-Paclitaxel without Depleting Tumor Stroma in Patient-Derived Pancreatic Cancer Xenografts.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:4

    Topics: Albumins; Animals; Antineoplastic Agents, Phytogenic; Deoxycytidine; Disease Models, Animal; Drug Synergism; Female; Gemcitabine; Humans; Mice; Microcirculation; Osteonectin; Paclitaxel; Pancreatic Neoplasms; Stromal Cells; Tumor Burden; Xenograft Model Antitumor Assays

2016
Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Gemcitabine; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heat-Shock Proteins; Humans; Immunohistochemistry; Male; Middle Aged; Proto-Oncogene Proteins c-akt; Survival Analysis; Unfolded Protein Response; Xenograft Model Antitumor Assays

2016
Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma.
    The Journal of pathology, 2016, Volume: 239, Issue:3

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Epithelial-Mesenchymal Transition; Gemcitabine; Humans; Mice; Pancreatic Neoplasms; Pancreatic Stellate Cells; Signal Transduction

2016
PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) augments the therapeutic effect of pegfilgrastim on gemcitabine-induced neutropenia.
    Cancer letters, 2016, 07-10, Volume: 377, Issue:1

    Topics: Animals; Biomarkers; Cell Movement; Deoxycytidine; Diglycerides; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Filgrastim; Gemcitabine; Granulocyte Colony-Stimulating Factor; Leukocyte Count; Mice, Inbred BALB C; Neutropenia; Neutrophils; Polyethylene Glycols; Receptors, Interleukin-8B; Recombinant Proteins; Time Factors

2016
Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells.
    Gastroenterology, 2016, Volume: 151, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Gemcitabine; Killer Cells, Natural; Mice; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt

2016
Ex Vivo Testing of Patient-Derived Xenografts Mirrors the Clinical Outcome of Patients with Pancreatic Ductal Adenocarcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Dec-15, Volume: 22, Issue:24

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Camptothecin; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Disease-Free Survival; Female; Gemcitabine; Heterografts; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Pancreatic Neoplasms; Retrospective Studies; Xenograft Model Antitumor Assays

2016
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
    Nature medicine, 2016, Volume: 22, Issue:8

    Topics: Aminopyridines; Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; CD8-Positive T-Lymphocytes; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Disease Progression; Fibrosis; Focal Adhesion Protein-Tyrosine Kinases; Gemcitabine; Humans; Immunoblotting; Immunohistochemistry; Immunotherapy; Immunotherapy, Adoptive; Mice; Pancreatic Neoplasms; Programmed Cell Death 1 Receptor; Reverse Transcriptase Polymerase Chain Reaction; Tumor Escape; Tumor Microenvironment

2016
The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma.
    Oncotarget, 2016, 11-15, Volume: 7, Issue:46

    Topics: Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Gemcitabine; Humans; Male; Mice; Neoplastic Stem Cells; Pancreatic Neoplasms; Peptide Fragments; Telomerase; Tumor Burden; Xenograft Model Antitumor Assays

2016
Coadministration of a Gloriosa superba extract improves the in vivo antitumoural activity of gemcitabine in a murine pancreatic tumour model.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Nov-15, Volume: 23, Issue:12

    Topics: Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Colchicine; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Glycosides; Herb-Drug Interactions; Humans; Liliaceae; Mice, Inbred C57BL; Pancreas; Pancreatic Neoplasms; Phytotherapy; Plant Extracts; Seeds

2016
Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.
    Disease models & mechanisms, 2016, 12-01, Volume: 9, Issue:12

    Topics: Adenocarcinoma; Animals; Apoptosis; Carbolines; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cytidine Deaminase; Deoxycytidine; Disease Models, Animal; DNA Damage; Down-Regulation; Drug Synergism; Enzyme Activation; Female; Gemcitabine; Heterocyclic Compounds, 4 or More Rings; Humans; Macrophages; Mice, Nude; Pancreatic Neoplasms; Treatment Outcome; Xenograft Model Antitumor Assays

2016
Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.
    Cancer research, 2016, 12-15, Volume: 76, Issue:24

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Deoxycytidine; Dideoxynucleosides; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Female; Flow Cytometry; Gemcitabine; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Nude; Positron-Emission Tomography; Radiopharmaceuticals; Xenograft Model Antitumor Assays

2016
Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer.
    Neoplasia (New York, N.Y.), 2016, Volume: 18, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Coculture Techniques; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Activation; Fibroblasts; Gemcitabine; Gene Expression; GTP-Binding Proteins; Humans; Laminin; Mice; Models, Biological; Pancreatic Neoplasms; Protein Glutamine gamma Glutamyltransferase 2; Transglutaminases; Xenograft Model Antitumor Assays

2016
Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4
    Immunology letters, 2017, Volume: 181

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokine-Induced Killer Cells; Cytokines; Cytotoxicity, Immunologic; Deoxycytidine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Gemcitabine; Humans; Immunomodulation; Immunosuppressive Agents; Lymphocyte Depletion; Male; Mice; Neoplasms; Phenotype; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory

2017
Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42.
    Neoplasia (New York, N.Y.), 2016, Volume: 18, Issue:12

    Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Synergism; Female; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Kaplan-Meier Estimate; Mice, Transgenic; Muscle, Skeletal; Pancreatic Neoplasms; Phenylbutyrates; Tumor Burden; Wasting Syndrome; Xenograft Model Antitumor Assays

2016
Microdose-Induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice.
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:2

    Topics: Animals; Antineoplastic Agents; Biomarkers; Carboplatin; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Female; Gemcitabine; Humans; Mass Spectrometry; Mice; Mutation; Neoplasms; Platinum; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2017
PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
    EMBO molecular medicine, 2017, Volume: 9, Issue:2

    Topics: Adenocarcinoma; Animals; B7-H1 Antigen; Carcinoma, Pancreatic Ductal; CD8-Positive T-Lymphocytes; Deoxycytidine; Disease Models, Animal; Gemcitabine; Mice; Models, Theoretical; Radiation-Sensitizing Agents; Treatment Outcome

2017
Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma.
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:1

    Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Gemcitabine; Humans; Mice; Neoplastic Stem Cells; Organoplatinum Compounds; Oxaliplatin; p21-Activated Kinases; Pancreatic Neoplasms; Protein Kinase Inhibitors; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

2017
A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance.
    Scientific reports, 2017, 01-30, Volume: 7

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Naphthalenes; Pancreatic Neoplasms; Xenograft Model Antitumor Assays

2017
Combination of anti-L1 cell adhesion molecule antibody and gemcitabine or cisplatin improves the therapeutic response of intrahepatic cholangiocarcinoma.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Bile Duct Neoplasms; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Cisplatin; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Mice; Molecular Targeted Therapy; Neural Cell Adhesion Molecule L1; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays

2017
Establishment of combined immuno-chemotherapy with systemically administered gemcitabine and intra-portal administration of interleukin-2 in murine models of liver metastases of pancreatic cancer.
    International journal of oncology, 2008, Volume: 33, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gemcitabine; Interleukin-2; Liver Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms; Portal Vein; T-Lymphocytes

2008
Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Oct-15, Volume: 14, Issue:20

    Topics: Adenocarcinoma; Adult; Aged; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carboplatin; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cetuximab; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Etoposide; Female; Gemcitabine; Gene Expression Profiling; Genes, ras; Humans; Immunoblotting; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Middle Aged; Mutation; Oligonucleotide Array Sequence Analysis; Paclitaxel; Polymerase Chain Reaction; Prognosis; Protein Kinase Inhibitors; Quinazolines; Radiation-Sensitizing Agents; Small Cell Lung Carcinoma; Tumor Suppressor Protein p53; Vinblastine; Vinorelbine; Xenograft Model Antitumor Assays

2008
The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer.
    BMC cancer, 2008, Nov-27, Volume: 8

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Necrosis; Neoplasm Metastasis; Neovascularization, Pathologic; Pancreatic Neoplasms; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2008
Antimetastatic effects of liposomal gemcitabine and empty liposomes in an orthotopic mouse model of pancreatic cancer.
    Pancreas, 2009, Volume: 38, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Liposomes; Luciferases; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Peritoneal Neoplasms; Transduction, Genetic

2009
INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model.
    Investigational new drugs, 2010, Volume: 28, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Doxorubicin; Female; Gemcitabine; Humans; Hydrazones; Inhibitory Concentration 50; Mice; Pancreatic Neoplasms; Treatment Outcome; Xenograft Model Antitumor Assays

2010
Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour models.
    International journal of oncology, 2009, Volume: 34, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combined Modality Therapy; Cytidine; Cytidine Triphosphate; Deoxycytidine; Disease Models, Animal; Drug Synergism; Female; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Nude; Middle Aged; Pancreatic Neoplasms; Rats; Rats, Inbred BN

2009
Pancreatic cancer: translating lessons from mouse models.
    JOP : Journal of the pancreas, 2009, Mar-09, Volume: 10, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cytidine Deaminase; Deoxycytidine; Disease Models, Animal; Gemcitabine; Genotype; Humans; Mice; Pancreatic Neoplasms; Pharmacogenetics; Polymorphism, Single Nucleotide; Ribonucleotide Reductases

2009
Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma.
    Journal of translational medicine, 2009, Mar-26, Volume: 7

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Interphase; Ligands; Mice; Mice, Inbred C57BL; Paclitaxel; Pancreatic Neoplasms; Receptors, sigma; Survival Analysis

2009
Quantification of mouse pulmonary cancer models by microcomputed tomography imaging.
    Cancer science, 2009, Volume: 100, Issue:8

    Topics: Adenoviridae; Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line, Tumor; Cisplatin; Deoxycytidine; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Gemcitabine; Genes, ras; Lentivirus; Luciferases; Luminescent Measurements; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Random Allocation; Time Factors; Tumor Suppressor Protein p53; X-Ray Microtomography; Xenograft Model Antitumor Assays

2009
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
    Science (New York, N.Y.), 2009, Jun-12, Volume: 324, Issue:5933

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Pancreatic Neoplasms; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor; Stromal Cells; Veratrum Alkaloids; Zinc Finger Protein GLI1

2009
Cancer. Breaching the cancer fortress.
    Science (New York, N.Y.), 2009, Jun-12, Volume: 324, Issue:5933

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Fibroblasts; Gemcitabine; Hedgehog Proteins; Humans; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Pancreatic Neoplasms; Signal Transduction; Stromal Cells

2009
Effects of the anti-VEGF monoclonal antibody bevacizumab in a preclinical model and in patients with refractory and multiple relapsed Hodgkin lymphoma.
    Journal of immunotherapy (Hagerstown, Md. : 1997), 2009, Volume: 32, Issue:5

    Topics: Adult; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cell Growth Processes; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Hodgkin Disease; Humans; Immunotherapy; Male; Mice; Mice, SCID; Neoplasm Transplantation; Tumor Burden; Vascular Endothelial Growth Factor A

2009
Multimodal approach for treatment of peritoneal surface malignancies in a tumour-bearing rat model.
    International journal of colorectal disease, 2010, Volume: 25, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chemotherapy, Adjuvant; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Gemcitabine; Hypothermia, Induced; Infusions, Parenteral; Male; Mitomycin; Neoplasm Transplantation; Peritoneal Neoplasms; Photochemotherapy; Rats; Taurine; Therapeutic Irrigation; Thiadiazines; Time Factors; Tumor Burden

2010
Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.
    Investigational new drugs, 2011, Volume: 29, Issue:3

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Death; Cell Line, Tumor; Cell Proliferation; Cytidine Deaminase; Deoxycytidine; Disease Models, Animal; Dogs; Fatty Acids; Gemcitabine; Humans; Mice; Nucleoside Deaminases; Treatment Outcome; Xenograft Model Antitumor Assays

2011
Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model.
    PloS one, 2010, Mar-04, Volume: 5, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Male; Mice; Mice, SCID; Pancreatic Neoplasms; Piperidines; Pyridines; Thiazoles

2010
Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer.
    Journal of cellular biochemistry, 2010, Volume: 110, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Deoxycytidine; Disease Models, Animal; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Indoles; Mice; Mice, SCID; NF-kappa B; Pancreatic Neoplasms; Quinazolines; Signal Transduction; Treatment Outcome; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays

2010
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models.
    Nature biotechnology, 2010, Volume: 28, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Erlotinib Hydrochloride; Gemcitabine; Genetic Engineering; Humans; Lung Neoplasms; Mice; Mutation; Neoplasms; Proto-Oncogene Proteins p21(ras); Quinazolines; Survival Analysis; Vascular Endothelial Growth Factor A

2010
Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Cell Line, Tumor; Cell Proliferation; Curcumin; Cyclin D1; Deoxycytidine; Disease Models, Animal; Down-Regulation; Drug Synergism; Gemcitabine; Humans; Matrix Metalloproteinase 9; Mice; Nanoparticles; Neoplasm Metastasis; NF-kappa B; Pancreatic Neoplasms; Polymers; Subcutaneous Tissue; Xenograft Model Antitumor Assays

2010
Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.
    Cell cycle (Georgetown, Tex.), 2010, Aug-01, Volume: 9, Issue:15

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Calcitriol; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Synergism; Enzyme Activation; Gemcitabine; Humans; Liver; Mice; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays

2010
Finding the tumor copycat: approximating a human cancer.
    Nature medicine, 2010, Volume: 16, Issue:9

    Topics: Adenocarcinoma; Animals; Animals, Genetically Modified; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Division; Deoxycytidine; Disease Models, Animal; Gemcitabine; Mice; Neoplasms

2010
Specific targeting of tumor endothelial cells by a shiga-like toxin-vascular endothelial growth factor fusion protein as a novel treatment strategy for pancreatic cancer.
    Neoplasia (New York, N.Y.), 2010, Volume: 12, Issue:10

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Cell Movement; Cell Proliferation; Cells, Cultured; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Endothelium, Vascular; Gemcitabine; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Pancreatic Neoplasms; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shiga Toxins; Signal Transduction; Survival Rate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2010
Genexol inhibits primary tumour growth and metastases in gemcitabine-resistant pancreatic ductal adenocarcinoma.
    HPB : the official journal of the International Hepato Pancreato Biliary Association, 2011, Volume: 13, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Humans; Male; Mice; Mice, Nude; Paclitaxel; Pancreatic Neoplasms

2011
[Contribution of microCT structural imaging to preclinical evaluation of hepatocellular carcinoma chemotherapeutics on orthotopic graft in ACI rats].
    Bulletin du cancer, 2011, Volume: 98, Issue:2

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Cell Line, Tumor; Contrast Media; Deoxycytidine; Disease Models, Animal; Disease Progression; Doxorubicin; Drug Monitoring; Gemcitabine; Liver Neoplasms; Male; Niacinamide; Organoplatinum Compounds; Oxaliplatin; Phenylurea Compounds; Pyridines; Rats; Rats, Inbred ACI; Sorafenib; Survival Analysis; Tumor Burden; X-Ray Microtomography; Xenograft Model Antitumor Assays

2011
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:5

    Topics: Animals; Antineoplastic Agents; Calibration; Cytidine Triphosphate; Deoxycytidine; Disease Models, Animal; Floxuridine; Fluorine; Gemcitabine; Humans; Magnetic Resonance Spectroscopy; Mice; Reference Standards; Tandem Mass Spectrometry

2011
Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Deoxycytidine; Disease Models, Animal; Drug Carriers; Gemcitabine; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lymph Nodes; Lymphatic Metastasis; Magnetite Nanoparticles; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanotubes, Carbon; Necrosis; Pancreatic Neoplasms

2011
A conjugate of gemcitabine with bisphosphonate (Gem/BP) shows potential as a targeted bone-specific therapeutic agent in an animal model of human breast cancer bone metastases.
    Oncology research, 2011, Volume: 19, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Calcium; Creatinine; Deoxycytidine; Diphosphonates; Disease Models, Animal; Drug Delivery Systems; Female; Gemcitabine; Humans; Injections, Intralesional; Mice; Mice, Inbred BALB C; Mice, Nude; Positron-Emission Tomography; Technetium; Tumor Cells, Cultured

2011
Local control of experimental malignant pancreatic tumors by treatment with a combination of chemotherapy and intratumoral 224radium-loaded wires releasing alpha-emitting atoms.
    Translational research : the journal of laboratory and clinical medicine, 2012, Volume: 159, Issue:1

    Topics: Alpha Particles; Animals; Antimetabolites, Antineoplastic; Brachytherapy; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Deoxycytidine; Disease Models, Animal; Female; Fluorouracil; Gemcitabine; Humans; Mice; Mice, Inbred C57BL; Pancreas; Pancreatic Neoplasms; Radiation-Sensitizing Agents; Radium

2012
Combined treatment of L1CAM antibodies and cytostatic drugs improve the therapeutic response of pancreatic and ovarian carcinoma.
    Cancer letters, 2012, Jun-01, Volume: 319, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cytostatic Agents; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Mice; Mice, SCID; Neural Cell Adhesion Molecule L1; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms

2012
Novel immunocompetent murine models representing advanced local and metastatic pancreatic cancer.
    The Journal of surgical research, 2012, Volume: 176, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gemcitabine; Immunocompetence; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Pancreas; Pancreatic Neoplasms; Severity of Illness Index; Spleen; Survival Rate

2012
The therapeutic effect of histone deacetylase inhibitor PCI-24781 on gallbladder carcinoma in BK5.erbB2 mice.
    Journal of hepatology, 2012, Volume: 57, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Benzofurans; Carcinoma; Carrier Proteins; Cell Division; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Gallbladder; Gallbladder Neoplasms; Gemcitabine; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Mice; Mice, Mutant Strains; Mucin-4; Phosphorylation; RNA, Messenger

2012
nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer.
    Cancer discovery, 2012, Volume: 2, Issue:3

    Topics: Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cytidine Deaminase; Deoxycytidine; Disease Models, Animal; Drug Synergism; Gemcitabine; Mice; Paclitaxel; Pancreatic Neoplasms

2012
Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer.
    Breast cancer research : BCR, 2012, Jul-19, Volume: 14, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Cluster Analysis; Deoxycytidine; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Female; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Mice; Protein Kinase Inhibitors; Protein Kinases; Retinoblastoma Protein; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; RNA Interference; RNA, Small Interfering; Staurosporine; Triple Negative Breast Neoplasms; Tumor Burden; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2012
Development of a unique mouse model for pancreatic cancer lymphatic metastasis.
    International journal of oncology, 2012, Volume: 41, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cluster Analysis; Deoxycytidine; Disease Models, Animal; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lymph Nodes; Lymphatic Metastasis; Mice; Pancreatic Neoplasms; Transplantation, Heterologous

2012
Enhanced antitumoral activity of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models.
    International journal of cancer, 2013, Apr-01, Volume: 132, Issue:7

    Topics: Animals; Antigen Presentation; Antimetabolites, Antineoplastic; Chlorocebus aethiops; Colorectal Neoplasms; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Herpes Simplex; Injections, Intralesional; Interferon-gamma; Mice; Mice, Inbred BALB C; Oncolytic Virotherapy; Simplexvirus; Spleen; T-Lymphocytes; Vero Cells

2013
Sequence dependence of MEK inhibitor AZD6244 combined with gemcitabine for the treatment of biliary cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jan-01, Volume: 19, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Biliary Tract Neoplasms; Cell Cycle; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Gemcitabine; Humans; Male; Mice; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Tumor Burden; Xenograft Model Antitumor Assays

2013
Combined effect of dehydroxymethylepoxyquinomicin and gemcitabine in a mouse model of liver metastasis of pancreatic cancer.
    Clinical & experimental metastasis, 2013, Volume: 30, Issue:4

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blotting, Western; Cell Movement; Cell Proliferation; Cyclohexanones; Deoxycytidine; Disease Models, Animal; Fluorescent Antibody Technique; Gemcitabine; Humans; Immunoenzyme Techniques; Interleukin-8; Liver Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2013
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.
    International journal of cancer, 2013, May-15, Volume: 132, Issue:10

    Topics: Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; DNA Damage; Doxorubicin; Drug Synergism; Etoposide; Gemcitabine; Imidazoles; Immunohistochemistry; Immunoprecipitation; Indoles; Mice; Pancreatic Neoplasms; Piperazines; Proto-Oncogene Proteins c-mdm2; Pyrrolidinones; Topoisomerase II Inhibitors

2013
Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: AC133 Antigen; Aldehyde Dehydrogenase 1 Family; Alleles; Animals; Antigens, CD; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Genomic Instability; Glycoproteins; GPI-Linked Proteins; Humans; Isoenzymes; Keratins; Male; Mesothelin; Mice; Middle Aged; Mutation; Neoplasm Metastasis; Neoplastic Stem Cells; Pancreatic Neoplasms; Peptides; Polyploidy; Retinal Dehydrogenase; Transplantation, Heterologous; Tumor Microenvironment

2012
Effects of a non thermal plasma treatment alone or in combination with gemcitabine in a MIA PaCa2-luc orthotopic pancreatic carcinoma model.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Tracking; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Luciferases, Firefly; Mice; Pancreatic Neoplasms; Plasma Gases; Tumor Burden; Whole Body Imaging; Xenograft Model Antitumor Assays

2012
Stearoyl gemcitabine nanoparticles overcome obesity-induced cancer cell resistance to gemcitabine in a mouse postmenopausal breast cancer model.
    Cancer biology & therapy, 2013, Volume: 14, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Nanoparticles; Obesity; Postmenopause; Random Allocation

2013
Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:4

    Topics: Administration, Metronomic; Administration, Oral; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Deoxyuridine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Gene Expression; HCT116 Cells; Humans; Lung Neoplasms; Mice; Prodrugs; Valproic Acid; Xenograft Model Antitumor Assays

2013
The rescue of miR-148a expression in pancreatic cancer: an inappropriate therapeutic tool.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression; Humans; Mice; MicroRNAs; Pancreatic Neoplasms; Proteome; Proteomics; Xenograft Model Antitumor Assays

2013
VEGF-C ShRNA inhibits pancreatic cancer growth and lymphangiogenesis in an orthotopic fluorescent nude mouse model.
    Anticancer research, 2013, Volume: 33, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gemcitabine; Gene Silencing; Green Fluorescent Proteins; Humans; Immunohistochemistry; Lymphangiogenesis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Vascular Endothelial Growth Factor C; Xenograft Model Antitumor Assays

2013
Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model.
    Cancer research, 2003, Jan-01, Volume: 63, Issue:1

    Topics: Animals; Camptothecin; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Pancreatic Neoplasms; Tumor Cells, Cultured

2003
Synergistic effect of sequential administration of mitoguazone (MGBG) and gemcitabine in treating tissue cultured human breast cancer cells and mammary rat tumors.
    Cancer investigation, 2003, Volume: 21, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Gemcitabine; Humans; Mammary Neoplasms, Experimental; Mitoguazone; Rats; Survival Analysis; Tumor Cells, Cultured

2003
Effects of intraperitoneal administration of gemcitabine and paclitaxel on hepatic regeneration in rats.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2003, Volume: 14, Issue:1

    Topics: Animals; Biopsy, Needle; Deoxycytidine; Disease Models, Animal; Gemcitabine; Hepatectomy; Immunohistochemistry; Injections, Intraperitoneal; Liver; Liver Function Tests; Liver Regeneration; Male; Paclitaxel; Rats; Rats, Inbred Strains; Sensitivity and Specificity

2003
Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats.
    Journal of neurosurgery, 2003, Volume: 99, Issue:5

    Topics: Animals; Antineoplastic Agents; Basal Ganglia; Brain Neoplasms; Brain Stem; Carboplatin; Convection; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Glioma; Injections, Intralesional; Male; Rats; Rats, Inbred F344

2003
Forced expression of cytidine deaminase confers sensitivity to capecitabine.
    Oncology, 2003, Volume: 65, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Survival; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Disease Models, Animal; DNA, Complementary; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Fluorouracil; Gemcitabine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Thymidine Phosphorylase; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2003
Tumour suppression induced by the macrophage activating lipopeptide MALP-2 in an ultrasound guided pancreatic carcinoma mouse model.
    Gut, 2004, Volume: 53, Issue:3

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Female; Flow Cytometry; Gemcitabine; Lipopeptides; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oligopeptides; Pancreas; Pancreatic Neoplasms; Spleen; Survival Analysis; Ultrasonography

2004
Chemoembolization of rat liver metastasis with microspheres and gemcitabine followed by evaluation of tumor cell load by chemiluminescence.
    Oncology reports, 2004, Volume: 11, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chemoembolization, Therapeutic; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Fluorouracil; Gemcitabine; Liver Neoplasms; Male; Microspheres; Neoplasm Transplantation; Organ Size; Rats; Rats, Inbred Strains; Tumor Burden

2004
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.
    Journal of the National Cancer Institute, 2004, May-19, Volume: 96, Issue:10

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Deoxycytidine; Disease Models, Animal; DNA, Neoplasm; Docetaxel; Doxorubicin; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Epirubicin; Female; Floxuridine; Gemcitabine; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Paclitaxel; Proto-Oncogene Proteins; Receptor, ErbB-2; Taxoids; Transplantation, Heterologous; Trastuzumab; Tumor Stem Cell Assay; Up-Regulation; Vinblastine; Vinorelbine

2004
Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-15, Volume: 10, Issue:16

    Topics: Animals; Antimetabolites, Antineoplastic; Base Sequence; Cell Survival; Deoxycytidine; Disease Models, Animal; DNA Primers; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Neoplastic; Kinetics; Leukemia L1210; Mice; Polymerase Chain Reaction; Time Factors

2004
Therapeutic effects of gemcitabine on cutaneous manifestations in an Adamantiades-Behçet's disease-like mouse model.
    Experimental dermatology, 2004, Volume: 13, Issue:10

    Topics: Alanine Transaminase; Animals; Behcet Syndrome; Cytokines; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Herpes Simplex; Immunosuppressive Agents; Mice; Mice, Inbred ICR; Skin Ulcer

2004
Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model.
    Clinical & experimental metastasis, 2004, Volume: 21, Issue:4

    Topics: Animals; Carcinoma, Lewis Lung; Chick Embryo; Deoxycytidine; Disease Models, Animal; Drug Screening Assays, Antitumor; Gemcitabine; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Streptokinase

2004
Combination treatment of CC531-lac-Z rat liver metastases by chemoembolization with pemetrexed disodium and gemcitabine.
    Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Chemoembolization, Therapeutic; Colorectal Neoplasms; Combined Modality Therapy; Death; Deoxycytidine; Disease Models, Animal; Gemcitabine; Glutamates; Guanine; Liver Neoplasms; Male; Neoplasm Metastasis; Pemetrexed; Rats; Rats, Inbred Strains

2005
Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases.
    International journal of cancer, 2005, Sep-01, Volume: 116, Issue:3

    Topics: Aerosols; Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Deoxycytidine; Disease Models, Animal; fas Receptor; Gemcitabine; Lung Neoplasms; Mice; Mice, Nude; Osteosarcoma; Tumor Cells, Cultured

2005
Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models.
    Human gene therapy, 2005, Volume: 16, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autoantigens; Carcinoma, Lewis Lung; Cell Line, Tumor; Collagen Type IV; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Endothelial Cells; Gemcitabine; Genetic Therapy; Genetic Vectors; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Plasmids; Recombinant Proteins; Treatment Outcome

2005
Aerosol delivery of chemotherapy in an orthotopic model of lung cancer.
    The European respiratory journal, 2005, Volume: 26, Issue:4

    Topics: Administration, Inhalation; Animals; Antineoplastic Agents; Carcinoma, Large Cell; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude

2005
Drug Discovery Technology and Development 2005 - IBC's Tenth World Congress. Cancer mouse models and other techniques for improved prediction of efficacy.
    IDrugs : the investigational drugs journal, 2005, Volume: 8, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Boronic Acids; Bortezomib; Camptothecin; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Forecasting; Gemcitabine; Green Fluorescent Proteins; Humans; Image Enhancement; Irinotecan; Luminescent Proteins; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Pyrazines; Red Fluorescent Protein; Technology, Pharmaceutical; Treatment Outcome

2005
The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-01, Volume: 12, Issue:3 Pt 1

    Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cytarabine; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Gemcitabine; Humans; In Vitro Techniques; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Mice, SCID; Time Factors; Xenograft Model Antitumor Assays

2006
Toxicity and efficacy of isolated lung perfusion with gemcitabine in a rat model of pulmonary metastases.
    The Thoracic and cardiovascular surgeon, 2006, Volume: 54, Issue:2

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Lung; Lung Neoplasms; Male; Random Allocation; Rats; Ribonucleotide Reductases; Treatment Outcome

2006
Novel orthotopic implantation model of human malignant pleural mesothelioma (EHMES-10 cells) highly expressing vascular endothelial growth factor and its receptor.
    Cancer science, 2006, Volume: 97, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Immunohistochemistry; Male; Mesothelioma; Mice; Mice, SCID; Neoplasm Transplantation; Pleural Neoplasms; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A

2006
Adjuvant treatment of pancreatic carcinoma in a clinically adapted mouse resection model.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2006, Volume: 6, Issue:3

    Topics: Adenocarcinoma; Animals; Chemotherapy, Adjuvant; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Pancreatic Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured

2006
An in vivo platform for translational drug development in pancreatic cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Aug-01, Volume: 12, Issue:15

    Topics: Animals; Antineoplastic Agents; Benzamides; Carcinoma; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Kinetics; Mice; Mice, Nude; Pancreatic Neoplasms; Predictive Value of Tests; Sirolimus; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2006
Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Dec-01, Volume: 12, Issue:23

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Deoxycytidine; Deoxycytidine Kinase; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Gemcitabine; Gene Expression Profiling; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Piperidines; Polymerase Chain Reaction; Predictive Value of Tests; Quinazolines; Radiation, Ionizing; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Transplantation, Heterologous

2006
Consistent liver metastases in a rat model by portal injection of microencapsulated cancer cells.
    Cancer research, 2006, Dec-01, Volume: 66, Issue:23

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Injections, Intravenous; Irinotecan; Liver Neoplasms, Experimental; Mice; Mice, Nude; Microspheres; Neoplasm Transplantation; Pancreatic Neoplasms; Portal Vein; Rats; Rats, Nude; Transplantation, Heterologous

2006
Pancreatic cancer: an update on a 'stealth' cancer. Treatment advances have been slow in coming. What makes this cancer so intractable?
    Harvard health letter, 2007, Volume: 32, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Early Diagnosis; Family Health; Gemcitabine; Humans; Mice; Pancreas; Pancreatic Neoplasms

2007
Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model.
    Gut, 2007, Volume: 56, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Combined Modality Therapy; Dendritic Cells; Deoxycytidine; Disease Models, Animal; Gemcitabine; Immunologic Memory; Injections, Intraperitoneal; Injections, Subcutaneous; Lung Neoplasms; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms; Survival Analysis; T-Lymphocytes, Cytotoxic; Treatment Outcome; Vaccination

2007
Establishment of a novel orthotopic xenograft model of human gallbladder carcinoma.
    Clinical & experimental metastasis, 2007, Volume: 24, Issue:3

    Topics: Animals; Deoxycytidine; Disease Models, Animal; Gallbladder Neoplasms; Gemcitabine; Humans; Keratin-7; Keratin-8; Ki-67 Antigen; Neoplasm Transplantation; Transplantation, Heterologous

2007
Synergistic anti-tumor effect of recombinant chicken fibroblast growth factor receptor-1-mediated anti-angiogenesis and low-dose gemcitabine in a mouse colon adenocarcinoma model.
    World journal of gastroenterology, 2007, May-07, Volume: 13, Issue:17

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cancer Vaccines; Cell Proliferation; Chickens; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1; Gemcitabine; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Random Allocation; Recombinant Proteins; Survival Rate

2007
Superiority of extended neoadjuvant chemotherapy with gemcitabine in pancreatic cancer: a comparative analysis in a clinically adapted orthotopic xenotransplantation model in SCID beige mice.
    Cancer biology & therapy, 2007, Volume: 6, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Disease Models, Animal; Gemcitabine; Mice; Mice, SCID; Neoadjuvant Therapy; Neoplasm Transplantation; Pancreatectomy; Pancreatic Neoplasms; Transplantation, Heterologous

2007
Effects of tumor selective replication-competent herpes viruses in combination with gemcitabine on pancreatic cancer.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Blotting, Western; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Oncolytic Viruses; Pancreatic Neoplasms; Simplexvirus; Virus Replication

2008
Effect of Z-360, a novel orally active CCK-2/gastrin receptor antagonist on tumor growth in human pancreatic adenocarcinoma cell lines in vivo and mode of action determinations in vitro.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Female; Gastrins; Gemcitabine; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Cholecystokinin B; Survival Rate; Xenograft Model Antitumor Assays

2008
Telomerase transcriptional targeting of inducible Bax/TRAIL gene therapy improves gemcitabine treatment of pancreatic cancer.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2008, Volume: 16, Issue:2

    Topics: Adenoviridae; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Genetic Therapy; Genetic Vectors; Humans; Mice; Models, Genetic; Pancreatic Neoplasms; Promoter Regions, Genetic; Telomerase; TNF-Related Apoptosis-Inducing Ligand; Transcription, Genetic

2008
Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cells, Cultured; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Nude; Pancreatic Neoplasms

2008
The analgesic effect of gemcitabine in mice.
    Romanian journal of internal medicine = Revue roumaine de medecine interne, 2006, Volume: 44, Issue:3

    Topics: Acetic Acid; Animals; Behavior, Animal; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Hot Temperature; Male; Mice; Pain Threshold; Reaction Time

2006
An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: potential application for preclinical studies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Mice; Mice, Inbred ICR; Mice, SCID; Oligopeptides; Pancreatic Neoplasms; Transplantation, Heterologous

1998
Intraoperative and early postoperative chemotherapy into the abdominal cavity using gemcitabine may prevent postoperative occurence of peritoneal carcinomatosis.
    Journal of surgical oncology, 2002, Volume: 79, Issue:1

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Disease Models, Animal; Drug Administration Schedule; Gemcitabine; Infusions, Parenteral; Intraoperative Care; Male; Neoplasm Seeding; Peritoneal Neoplasms; Postoperative Care; Rats; Rats, Wistar

2002
[Regional intra-arterial infusion chemotherapy for pancreatic cancer: an experimental study].
    Zhonghua yi xue za zhi, 2002, Mar-25, Volume: 82, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Disease Models, Animal; Dogs; Gemcitabine; Infusions, Intra-Arterial; Kidney; Male; Pancreatic Neoplasms; Tissue Distribution

2002