gemcitabine has been researched along with Cancer of Colon in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (18.37) | 18.2507 |
| 2000's | 31 (31.63) | 29.6817 |
| 2010's | 45 (45.92) | 24.3611 |
| 2020's | 4 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Lushington, G; McAlpine, SR; McGuire, KL; Otrubova, K; Vander Velde, D | 1 |
| Aherne, GW; Box, G; Boxall, KJ; Collins, I; de Haven Brandon, AK; Eccles, SA; Eve, PD; Garrett, MD; Hayes, A; Lainchbury, M; Matthews, TP; McHardy, T; Raynaud, FI; Reader, JC; Valenti, MR; Walton, MI | 1 |
| Bhardwaj, TR; Gaba, T; Malhotra, M; Matharoo, S; Rawal, RK; Sharma, R; Singla, N | 1 |
| Han, Z; Li, Y; Liu, J; Tian, C; Wang, M; Wang, X; Yang, J; Zhang, Z | 1 |
| Dahabreh, IJ; García-Albéniz, X; Hernán, MA; Howlader, N; Logan, RW; Mariotto, AB; Petito, LC | 1 |
| Angelis De, V; Chovanec, M; Hlavčák, P; Janega, P; Jurišová, S; Macák, D; Makovník, M; Mardiak, J; Mego, M; Pinďák, D; Rejleková, K | 1 |
| Cepero, A; Martin-Guerrero, SM; Martin-Oliva, D; Melguizo, C; Munoz-Gamez, JA; Ortiz, R; Prados, J; Quinonero, F; Urbano, D | 1 |
| Chen, X; Gao, G; Guo, Y; Liang, G; Liu, J; Wang, D; Wu, FG; Wu, Y; Zhang, X; Zhao, Y | 1 |
| Avraham, R; Barshack, I; Barzily-Rokni, M; Bhatia, SN; Brandis, A; Bu, J; Chatman, K; Cooper, ZA; Danino, T; Ferrone, CR; Flaherty, KT; Fleming, J; Frederick, DT; Fuks, G; Garrett, WS; Gavert, N; Geller, LT; Gevers, D; Golan, T; Golub, TR; Gopalakrishnan, V; Gurbatri, C; Hurd, MW; Huttenhower, C; Johnston, SE; Jonas, OH; Katz, M; Kim, M; Ligorio, M; Livny, J; Maitra, A; Mandinova, A; Michaud, M; Mosher, CM; Nejman, D; Reuben, A; Sandbank, J; Shee, K; Shental, N; Skalak, M; Smith, DA; Straussman, R; Thaiss, CA; Thayer, SP; Trauger, SA; Wargo, JA; Zwang, Y | 1 |
| Fukuda, M; Hosokawa, M; Iwakawa, S; Masuda, A; Tanaka, S; Ueda, K | 1 |
| Albrecht, MH; Gruber-Rouh, T; Hammerstingl, R; Lahrsow, M; Thompson, ZM; Vogl, TJ | 1 |
| Arafat, K; Attoub, S; Iratni, R; Khalaf, T; Sulaiman, S | 1 |
| Jain, A; Jain, AK; Prajapati, SK; Shrivastava, C | 1 |
| Ali, M; Batool, F; Fatima, M; Iqbal Ahmed, MM; Munch-Petersen, B; Mutahir, Z; Riaz, A | 1 |
| Choi, MH; Kim, JS; Lim, SK; Shin, DH | 1 |
| Boulware, SB; Christensen, LA; Coghlan, L; Finch, RA; Thames, H; Vasquez, KM | 1 |
| Li, R; Li, W; Shi, L; Shuai, X; Tao, K; Wang, G; Wu, K; Yin, Y; Zhang, P; Zhao, E | 1 |
| Clements, D; Giacomantonio, CA; Gujar, SA; Hill, R; Lee, PW; Madureira, PA; Rabb, M; Waisman, DM | 1 |
| Brons, S; Combs, SE; Debus, J; Haberer, T; Schlaich, F; Weber, KJ | 1 |
| Alami, M; Boissenot, T; Brion, JD; Couvreur, P; Desmaële, D; Hamze, A; Maksimenko, A; Mougin, J; Provot, O; Pruvost, A; Zouhiri, F | 1 |
| Du, QG; Guo, XY; Han, S; Hao, ZM; Liu, GS; Lv, YF; Wang, P; Zhu, SM | 1 |
| Hirano, S; Kuroda, A; Kuwatani, T; Kyogoku, N; Maki, T; Miyauchi, K; Shichinohe, T; Takeuchi, S; Tsuchikawa, T; Wada, M; Yamamura, Y | 1 |
| Galsky, MD; Gimpel-Tetra, K; Godbold, J; Holcombe, RF; Lee, KM; Lowe, N; Misiukiewicz, K; Oh, WK; Posner, M; Soto, R; Tsao, CK | 1 |
| Faez, L; Garrido, M; Jiménez-Fonseca, P; Menendez, MD; Rodriguez, D; Ruiz, AL; Sanchez Lorenzo, ML; Solis, MP; Uriol, E; Viéitez, JM | 1 |
| Choi, MG; Jeong, D; Min, D; Na, K | 1 |
| Dai, Y; Ishibashi, O; Kondo, T; Maeda, M; Ohkohchi, N; Watanabe, M | 1 |
| Byrne, WL; Cummins, J; Lehouritis, P; McCarthy, FO; Murphy, CT; Reid, G; Stanton, M; Tangney, M; Urbaniak, C | 1 |
| Barda, D; Barnard, D; Beckmann, R; Burke, T; Diaz, HB; Donoho, G; Jones, B; King, C; Marshall, M | 1 |
| Jiang, Y; Lin, Z; Liu, G; Ren, N; Shi, Y; Xu, W | 1 |
| Kinoshita, A; Koike, K; Koyama, M; Nishino, H; Tanaka, K | 1 |
| Baidoo, KE; Brechbiel, MW; Milenic, DE; Yong, KJ | 1 |
| Cao, YQ; Jing, K; Liang, TJ; Ma, MZ; Wang, XJ; Zhou, ZM | 1 |
| Correale, P; Cusi, MG; Del Vecchio, MT; Fioravanti, A; Francini, E; Francini, G; Ginanneschi, C; Martellucci, I; Montagnani, F; Remondo, C; Rotundo, MS; Tagliaferri, P; Tassone, P | 1 |
| Armesilla, AL; Brown, J; Darling, JL; Goessl, E; Guo, X; Pandey, S; Wang, W; Xu, B | 1 |
| Bao, J; Bender, DM; Dantzig, AH; Diseroad, WD; Law, KL; Magnus, NA; McCarthy, JR; Perkins, EJ; Peterson, JA; Pu, YJ; Remick, DM; Reutzel-Edens, SM; Starling, JJ; Stephenson, GA; Vaid, RK; Zhang, D | 1 |
| Atanassow, V; Braumann, C; Caldenas, S; Hartmann, J; Kilian, M; Makareinis, A; Raue, W; Schwenk, W | 1 |
| Dalgleish, AG; Fowler, DW; Liu, WM; Smith, P | 1 |
| Cercueil, JP; Chauffert, B; Ghiringhelli, F; Guiu, B; Guiu, S; Ladoire, S; Ortega-Deballon, P; Vincent, J | 1 |
| Correale, P; Del Vecchio, MT; Francini, G; Ginanneschi, C; Licchetta, A; Loiacono, L; Mannucci, S; Migali, C; Remondo, C; Rotundo, MS; Tagliaferri, P; Tassone, P; Tsang, KY | 1 |
| Abbruzzese, A; Arcuri, FP; Caraglia, M; Carducci, A; Correale, P; Del Vecchio, MT; Loiacono, L; Marra, M; Migali, C; Misso, G; Remondo, C; Tagliaferri, P; Tassone, P | 1 |
| Dalgleish, AG; Gravett, AM; Liu, WM | 1 |
| Alvarez, PJ; Aranega, A; Burgos, M; Hita, F; Melguizo, C; Ortiz, R; Prados, J; Rama, AR; Ramos, JL; Rodríguez-Serrano, F | 1 |
| Azzariti, A; Bocci, G; Chiarappa, P; Del Bufalo, D; Del Tacca, M; Fioravanti, A; Mangia, A; Paradiso, A; Porcelli, L; Quatrale, AE; Sebastian, S; Simone, GM; Sini, P | 1 |
| Moon, S; Na, K; Yang, SG | 1 |
| Benninger, K; Carson, WE; Chaudhury, AR; Guenterberg, K; Guttridge, DC; Jaime-Ramirez, AC; Khan, M; Kondadasula, SV; Kreiner, M; Kuppusamy, P; La Perle, KM; Lesinski, GB; Mundy-Bosse, BL; Young, G | 1 |
| Baker, JH; Kyle, AH; Minchinton, AI | 1 |
| Lee, JW; Na, K; Yang, SG | 1 |
| Aracil, M; Arguelaguet, E; Hernández-Losa, J; Jimeno, J; Marés, R; Pons, B; Ramón Y Cajal, S; Somoza, R; Teixidó, C | 1 |
| Downward, J; Hancock, DC; Howell, M; Kelly, G; Kuznetsov, H; Marani, M; Molina-Arcas, M; Saunders, B; Steckel, M; Warne, PH; Weigelt, B | 1 |
| Li, W; Liu, H; Qu, X; Sun, C; Yue, B; Zhao, C | 1 |
| Li, G; Li, W; Qu, X; Sun, C; Xue, X; Zhao, C | 1 |
| Baba, H; Goseki, N; Kuwabara, H; Mitsuoka, A; Nakamura, H; Sanada, T; Watanabe, S; Yamamoto, Y | 1 |
| Adjei, AA | 1 |
| Baay, MF; de Pooter, CM; Korst, AE; Lambrechts, HA; Lardon, F; Pattyn, GG; Pauwels, B; Vermorken, JB | 1 |
| Bernacki, RJ; Chaudhary, ND; Greco, W; Hoffman, RM; Kobayashi, T; Mazurchuk, R; Pera, P; Spernyak, J; Veith, J; Wu, M | 1 |
| Auditore-Hargreaves, K; Axworthy, D; Dearstyne, E; Graves, SS; Gray, D; Jones, HM; Lin, Y; Pantalias, A; Sanderson, J; Schultz, J; Zuo, Y | 1 |
| Babarina, A; Kischkel, FC; Waldenmaier, DS | 1 |
| Li, M; Rinehart, JJ; Wang, H; Zhang, R | 1 |
| Berger, MR; Leible, M; Sänger, J; Seelig, MH | 1 |
| Adrian, TE; Ding, XZ; Hennig, R; Jovanovic, BD; Tong, WG; Witt, RC | 1 |
| Aquino, A; Bonmassar, E; Caraglia, M; Correale, P; Cusi, MG; Del Vecchio, MT; Formica, V; Francini, G; Giorgi, G; La Placa, M; Micheli, L; Montagnani, F; Nencini, C; Prete, S; Prete, SP; Terrosi, C; Tsang, KY | 1 |
| Bobek, V; Boubelik, M; Douglas, J; Kolostova, K; Kovarik, J; Pavlasek, J; Pinterova, D; Teyssler, P | 1 |
| Aquino, A; Bonmassar, E; Correale, P; Cusi, MG; Del Vecchio, MT; Ferrari, F; Francini, G; Giorgi, G; Intrivici, C; Marsili, S; Micheli, L; Nencini, C; Placa, ML; Tsang, KY | 1 |
| Cheng, XC; He, QM; Hou, JM; Hu, B; Jiang, Y; Kan, B; Li, G; Li, J; Tian, L; Wang, L; Wei, YQ; Wen, YJ; Xiao, F; Yao, B; Zhang, L; Zhang, R; Zhao, X; Zhou, Q | 1 |
| Bergman, AM; Eijk, PP; Hubeek, I; Peters, GJ; Ruiz van Haperen, VW; Smid, K; van den Ijssel, P; Veerman, G; Ylstra, B | 1 |
| Bergman, AM; Costa, JL; Meijer, GA; Oudejans, CB; Peters, GJ; Smid, K; van de Wiel, MA; Ylstra, B | 1 |
| Bleichrodt, RP; Boerman, OC; Goldenberg, DM; Koppe, MJ; Oyen, WJ; Verhofstad, AA | 1 |
| Huang, FY; Jiao, CL; Wu, RL; Zheng, SJ; Zheng, SP | 1 |
| Bussom, S; Cheng, YC; Lam, W; Leung, CH | 1 |
| Chang, SY; Chang, WS; Kang, CY; Kim, YJ; Kim, YS; Ko, HJ; Ko, SY; Sakaguchi, S | 1 |
| Chaudhari, AA; Kang, HS; Kim, IS; Kim, NS; Kim, TH; Lee, YJ; Park, JH; Park, SY; Seol, DW; Seol, JW | 1 |
| Ahn, E; Flores, A; Lopes, G; Quesada, J; Ribeiro, A; Rocha-Lima, CM | 1 |
| Cavallaro, G; Cosco, D; Fresta, M; Giammona, G; Licciardi, M; Paolino, D | 1 |
| Bertoldi, I; Correale, P; Fioravanti, A; Francini, G; Miracco, C; Montagnani, F | 1 |
| Boven, E; Braakhuis, BJ; Peters, GJ; Ruiz van Haperen, VW; Veerman, G | 1 |
| Bergman, AM; Braakhuis, BJ; Kuiper, CM; Peters, GJ; Ruiz van Haperen, VW; Veerman, G | 1 |
| Bergman, AM; Kuiper, CM; Peters, GJ; Ruiz van Haperen, VW; Veerman, G | 1 |
| Findenig, G; Fritzer, M; Lhotka, C; Schön, HJ; Szekeres, T | 1 |
| Boven, E; Noordhuis, P; Peters, GJ; Ruiz van Haperen, VW; Veerman, G; Vermorken, JB | 1 |
| Fujita, F; Fujita, M; Inaba, H; Taguchi, T | 1 |
| Braakhuis, BJ; Noordhuis, P; Peters, GJ; Pinedo, HM; Ruiz van Haperen, VW; Veerman, G; Vermorken, JB | 1 |
| Alvord, WG; Gazdar, AF; Gray-Goodrich, M; Koo, HM; McWilliams, MJ; Mikheev, A; Monks, A; Oie, HK; Paull, KD; Rubinstein, LV; Vande Woude, GF; Zarbl, H | 1 |
| Boder, GB; Grindey, GB; Hertel, LW; Houghton, JA; Houghton, PJ; Merriman, RL; Rutherford, PG; Schultz, RM; Tanzer, LR | 1 |
| Eisbruch, A; Lawrence, TS; Shewach, DS | 1 |
| Peters, GJ; Ruiz van Haperen, VW; van Moorsel, CJ; Veerman, G | 1 |
| Peters, GJ; Pinedo, HM; Ruiz van Haperen, VW; Smitskamp-Wilms, E; Veerman, G | 1 |
| Chang, EY; Hahn, TM; Lawrence, TS; Shewach, DS | 1 |
| Grem, JL; Kao, V; Ren, Q | 1 |
| Cvitkovic, E; Faivre, S; Raymond, E; Woynarowski, JM | 1 |
| Mendelsohn, LG; Teng, CH; Tonkinson, JL; Worzalla, JF | 1 |
| Endo, M; Machida, H; Miura, S; Sasaki, T; Satoh, H; Yoshimura, Y | 1 |
| Aung, TT; Davis, MA; Ensminger, WD; Lawrence, TS | 1 |
| Jiang, H; Li, L; Plunkett, W; Shen, Y; Yang, LY | 1 |
| Czerniak, PM; Devenny, JJ; Gravallese, EM; Kerr, JS; Longtine, J; Slee, AM; Wexler, EJ; Wong, MK | 1 |
| Bhupalam, L; Fleming, DR; Glisson, SD; Goldsmith, GH; LaRocca, RV; Michelson, GD | 1 |
| Davis, MA; Hough, A; Lawrence, TS; Rehemtulla, A | 1 |
| Amadori, D; De Paola, F; Frassineti, GL; Ricotti, L; Tesei, A; Zoli, W | 1 |
| Noordhuis, P; Peters, GJ; Ruiz van Haperen, VW; Veerman, G; Vermorken, JB | 1 |
2 review(s) available for gemcitabine and Cancer of Colon
| Article | Year |
|---|---|
Preclinical and clinical studies with combinations of pemetrexed and gemcitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Thymidylate Synthase | 2002 |
Gemcitabine-mediated radiosensitization.
Topics: Carcinoma, Squamous Cell; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Deoxycytidine; Gemcitabine; Head and Neck Neoplasms; Humans; Radiation-Sensitizing Agents; Research Design; Tumor Cells, Cultured | 1997 |
6 trial(s) available for gemcitabine and Cancer of Colon
| Article | Year |
|---|---|
Phase Ib study of dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin in patients with advanced solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carboplatin; Cisplatin; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gemcitabine; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Quinolones; Thromboembolism; Treatment Outcome; Urinary Bladder Neoplasms; Young Adult | 2014 |
Immunity feedback and clinical outcome in colon cancer patients undergoing chemoimmunotherapy with gemcitabine + FOLFOX followed by subcutaneous granulocyte macrophage colony-stimulating factor and aldesleukin (GOLFIG-1 Trial).
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunotherapy; Injections, Subcutaneous; Interleukin-2; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Recombinant Proteins; Treatment Outcome | 2008 |
Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Disease Progression; Female; Fluorouracil; Forkhead Transcription Factors; Gemcitabine; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunohistochemistry; Immunotherapy; Leucovorin; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prognosis; Recombinant Proteins; Survival Analysis; T-Lymphocytes, Regulatory | 2010 |
Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer
Topics: Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Colorectal Neoplasms; Cytotoxicity, Immunologic; Deoxycytidine; Disease Progression; Female; Flow Cytometry; Fluorouracil; Gemcitabine; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunotherapy; Infusions, Intravenous; Interleukin-2; Leucovorin; Male; Organoplatinum Compounds; Oxaliplatin; T-Lymphocytes, Regulatory; Thymidylate Synthase; Treatment Outcome | 2005 |
Oxaliplatin and fixed-rate infusional gemcitabine in the second-line treatment of patients with metastatic colon cancer: final results of a Phase II trial prematurely closed as a result of poor accrual.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Gemcitabine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Pyridines; Salvage Therapy; Survival Analysis | 2007 |
Phase I study of paclitaxel and day 1/day 8 gemcitabine in patients with solid malignancies.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Deoxycytidine; Diarrhea; Esophageal Neoplasms; Exanthema; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasm Staging; Neoplasms, Unknown Primary; Neutropenia; Paclitaxel; Pancreatic Neoplasms; Paresthesia; Urinary Bladder Neoplasms; Vomiting | 2000 |
90 other study(ies) available for gemcitabine and Cancer of Colon
| Article | Year |
|---|---|
Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Depsipeptides; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2008 |
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.
Topics: Administration, Oral; Aminopyridines; Animals; Antineoplastic Agents; Checkpoint Kinase 1; Child; Colonic Neoplasms; DNA Damage; Drug Design; Humans; Mice; Mice, Nude; Mice, Transgenic; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2012 |
Design, synthesis and ex vivo evaluation of colon-specific azo based prodrugs of anticancer agents.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Cell Line, Tumor; Colon; Colonic Neoplasms; Drug Design; Drug-Related Side Effects and Adverse Reactions; Feces; Humans; Inhibitory Concentration 50; Mesalamine; Prodrugs; Rats | 2013 |
Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstitued-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d]pyrimidine analogues as novel CHK1 inhibitors.
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Checkpoint Kinase 1; Colonic Neoplasms; Drug Screening Assays, Antitumor; HEK293 Cells; HT29 Cells; Humans; Models, Molecular; Protein Kinase Inhibitors; Purines; Pyrimidines; Structure-Activity Relationship | 2018 |
Estimates of Overall Survival in Patients With Cancer Receiving Different Treatment Regimens: Emulating Hypothetical Target Trials in the Surveillance, Epidemiology, and End Results (SEER)-Medicare Linked Database.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colonic Neoplasms; Deoxycytidine; Erlotinib Hydrochloride; Fluorouracil; Gemcitabine; Humans; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms; Retrospective Studies; SEER Program; Survival Rate; United States | 2020 |
Squamous cell carcinoma of the colon - a case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Colonic Neoplasms; Deoxycytidine; Gemcitabine; Humans; Male | 2020 |
Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Deoxycytidine; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Irinotecan; Liver Neoplasms; Mice; Neoplastic Stem Cells; Pancreatic Neoplasms; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Xenograft Model Antitumor Assays | 2021 |
Dual Gate-Controlled Therapeutics for Overcoming Bacterium-Induced Drug Resistance and Potentiating Cancer Immunotherapy.
Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Cell Line; Ciprofloxacin; Colonic Neoplasms; Deoxycytidine; Drug Resistance, Bacterial; Escherichia coli; Gemcitabine; Humans; Mice | 2021 |
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Colonic Neoplasms; Deoxycytidine; Drug Resistance, Neoplasm; Gammaproteobacteria; Gemcitabine; Humans; Male; Mice; Mice, Inbred BALB C; Mycoplasma hyorhinis; Neoplasms, Experimental; Pancreatic Neoplasms | 2017 |
Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Camptothecin; Colonic Neoplasms; Cytarabine; Decitabine; Deoxycytidine; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Etoposide; Gemcitabine; HCT116 Cells; Humans; Irinotecan; Phosphorylation | 2017 |
Survival of patients with non-resectable, chemotherapy-resistant colorectal cancer liver metastases undergoing conventional lipiodol-based transarterial chemoembolization (cTACE) palliatively versus neoadjuvantly prior to percutaneous thermal ablation.
Topics: Ablation Techniques; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoembolization, Therapeutic; Cisplatin; Colonic Neoplasms; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Ethiodized Oil; Female; Gemcitabine; Humans; Hyperthermia, Induced; Irinotecan; Laser Therapy; Liver Neoplasms; Male; Microwaves; Middle Aged; Mitomycin; Neoadjuvant Therapy; Palliative Care; Prognosis; Rectal Neoplasms; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult | 2018 |
Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Deoxycytidine; Drug Synergism; Fluorouracil; Gemcitabine; Glycosides; HCT116 Cells; HT29 Cells; Humans; Organoplatinum Compounds; Oxaliplatin; Triterpenes | 2018 |
Hyaluronic acid conjugated multi-walled carbon nanotubes for colon cancer targeting.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Folic Acid; Gemcitabine; Humans; Hyaluronic Acid; Nanotubes, Carbon; Rats | 2019 |
Recombinant deoxyribonucleoside kinase from Drosophila melanogaster can improve gemcitabine based combined gene/chemotherapy for targeting cancer cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Drosophila melanogaster; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Gemcitabine; Genetic Therapy; Genetic Vectors; HCT116 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; MCF-7 Cells; Phosphotransferases (Alcohol Group Acceptor); Recombinant Proteins; Substrate Specificity; Transfection | 2019 |
Enhanced antitumor efficacy of gemcitabine-loaded temperature-sensitive liposome by hyperthermia in tumor-bearing mice.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Caspase 7; Chromatin; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; DNA Fragmentation; Dose-Response Relationship, Drug; Gemcitabine; Hyperthermia, Induced; Inhibitory Concentration 50; Liposomes; Mice; Mice, Inbred BALB C; Temperature | 2014 |
Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chromatin Immunoprecipitation; Colonic Neoplasms; Deoxycytidine; DNA, Neoplasm; Drug Synergism; Female; Gemcitabine; Humans; Mice; Mice, Nude; Oligonucleotides; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
HMGB1 recruits myeloid derived suppressor cells to promote peritoneal dissemination of colon cancer after resection.
Topics: Animals; Antimetabolites, Antineoplastic; Ascitic Fluid; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gemcitabine; HMGB1 Protein; Mice; Mice, Inbred BALB C; Myeloid Cells; Peritoneal Neoplasms; Recombinant Proteins | 2013 |
Gemcitabine-mediated tumour regression and p53-dependent gene expression: implications for colon and pancreatic cancer therapy.
Topics: 14-3-3 Proteins; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Cell Line, Tumor; Chromium; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; DNA Damage; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, SCID; Models, Biological; Pancreatic Neoplasms; Protein Biosynthesis; Proto-Oncogene Proteins; Remission Induction; Transcription, Genetic; Tumor Suppressor Protein p53 | 2013 |
Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carbon; Cell Cycle; Cell Line, Tumor; Cell Separation; Chemoradiotherapy; Cisplatin; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Glioblastoma; Humans; Ions; Lung Neoplasms; Paclitaxel; Pancreatic Neoplasms; Photons; Propidium; Radiotherapy; Relative Biological Effectiveness; Time Factors | 2013 |
Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Deoxycytidine; Drug Carriers; Drug Design; Gemcitabine; Humans; Intracellular Space; Mice; Nanocomposites; Squalene; Stilbenes; Xenograft Model Antitumor Assays | 2014 |
Paclitaxel and gemcitabine combinational drug-loaded mucoadhesive delivery system in the treatment of colon cancers.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Survival; Chitosan; Colonic Neoplasms; Deoxycytidine; Drug Carriers; Drug Liberation; Drug Therapy, Combination; Gemcitabine; Humans; Mice; Nanoparticles; Paclitaxel; Succinic Anhydrides; Survival Rate; Xenograft Model Antitumor Assays | 2015 |
The key role of calreticulin in immunomodulation induced by chemotherapeutic agents.
Topics: Animals; Antigens, Surface; Antineoplastic Agents; Apoptosis; Calreticulin; Camptothecin; Carcinoma, Lewis Lung; CD3 Complex; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Histocompatibility Antigens Class I; Humans; Immunomodulation; Lymphocyte Count; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitomycin; Mitoxantrone; Neoplasm Transplantation; Neoplasms, Experimental; Protein Transport; T-Lymphocytes; Tumor Microenvironment | 2015 |
Gemcitabine plus capecitabine (Gem-Cape) biweekly in chemorefractory metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Capecitabine; Colonic Neoplasms; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Peritoneal Neoplasms; Rectal Neoplasms; Retreatment; Retrospective Studies; Survival Rate | 2015 |
Photochemical tissue penetration via photosensitizer for effective drug penetration in a non-vascular tumor.
Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Deoxycytidine; Drug Delivery Systems; Fluorescein; Gemcitabine; Light; Male; Materials Testing; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Polyurethanes; Singlet Oxygen; Surface Properties | 2015 |
[A Case of Gastrointestinal Metastases of Breast Cancer Effectively Treated with Gemcitabine and Paclitaxel Combination Chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Deoxycytidine; Female; Gemcitabine; Humans; Intestinal Obstruction; Middle Aged; Paclitaxel; Stomach Neoplasms | 2015 |
Local bacteria affect the efficacy of chemotherapeutic drugs.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Cladribine; Colonic Neoplasms; Deoxycytidine; Escherichia coli; Female; Gemcitabine; Injections, Intralesional; Injections, Subcutaneous; Listeria; Mice; Neoplasm Transplantation; Skin; Treatment Outcome; Vidarabine | 2015 |
LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Checkpoint Kinase 1; Colonic Neoplasms; Deoxycytidine; DNA Damage; Female; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phenylurea Compounds; Protein Kinase Inhibitors; Protein Kinases; Pyrazines; Xenograft Model Antitumor Assays | 2016 |
Adenovirus-Mediated E2F-1 Gene Transfer Augments Gemcitabine-Induced Apoptosis in Human Colon Cancer Cells.
Topics: Adenoviridae; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Deoxycytidine; DNA Fragmentation; E2F1 Transcription Factor; Gemcitabine; Gene Transfer Techniques; Humans; Inhibitory Concentration 50; Microscopy, Fluorescence; Mutation; Tumor Suppressor Protein p53 | 2015 |
[A Case of Primary Cancer of the Pancreas and Colon Treated with the Combination of Gemcitabine and TS-1].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxycytidine; Gemcitabine; Humans; Male; Middle Aged; Neoplasms, Multiple Primary; Pancreatic Neoplasms; Silicates; Titanium; Treatment Outcome | 2016 |
Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; DNA Damage; DNA Repair; Gemcitabine; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Lead Radioisotopes; Mice; Trastuzumab | 2016 |
Gemcitabine-based polymer-drug conjugate for enhanced anticancer effect in colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Survival; Colonic Neoplasms; Delayed-Action Preparations; Deoxycytidine; Drug Carriers; Drug Liberation; Gemcitabine; HT29 Cells; Humans; Mice, Nude; Micelles; Polyesters; Polyethylene Glycols; Rats; Tumor Burden | 2016 |
Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Copper; Deoxycytidine; Disulfiram; Drug Resistance, Neoplasm; Drug Synergism; Electrophoretic Mobility Shift Assay; Female; Fluorouracil; Gemcitabine; Humans; NF-kappa B; Ribonucleoside Diphosphate Reductase; Thymidylate Synthase; Tumor Suppressor Proteins | 2010 |
Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Crystallization; Crystallography, X-Ray; Cytidine; Deoxycytidine; Gemcitabine; Humans; Mice; Models, Molecular; Molecular Conformation; Prodrugs; Solubility | 2009 |
Multimodal approach for treatment of peritoneal surface malignancies in a tumour-bearing rat model.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chemotherapy, Adjuvant; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Gemcitabine; Hypothermia, Induced; Infusions, Parenteral; Male; Mitomycin; Neoplasm Transplantation; Peritoneal Neoplasms; Photochemotherapy; Rats; Taurine; Therapeutic Irrigation; Thiadiazines; Time Factors; Tumor Burden | 2010 |
Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses.
Topics: Animals; Antigen Presentation; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Colonic Neoplasms; Culture Media, Conditioned; Cyclophosphamide; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Deoxycytidine; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; HLA-A1 Antigen; Humans; Lymphocyte Activation; Male; Mice; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Premedication; T-Lymphocytes, Cytotoxic | 2010 |
Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Catheter Ablation; Colonic Neoplasms; Deoxycytidine; Gemcitabine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Tomography, X-Ray Computed; Treatment Outcome | 2010 |
Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents; Blotting, Western; Camptothecin; Cell Line, Tumor; Cetuximab; Colonic Neoplasms; Deoxycytidine; Drug Synergism; ErbB Receptors; Fluorouracil; Gemcitabine; Genes, ras; Humans; Irinotecan; Killer Cells, Lymphokine-Activated; Mutation; Panitumumab; Up-Regulation | 2010 |
The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies.
Topics: Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Artemisinins; Artesunate; Blotting, Western; Breast Neoplasms; Cell Proliferation; Colonic Neoplasms; Deoxycytidine; Female; Flow Cytometry; Gemcitabine; Humans; Lenalidomide; Lung Neoplasms; Organoplatinum Compounds; Oxaliplatin; Thalidomide; Tumor Cells, Cultured | 2011 |
E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carboplatin; Carcinoma; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Genetic Therapy; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Paclitaxel; Transfection; Viral Proteins | 2010 |
Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aurora Kinase B; Aurora Kinases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Male; Mice; Mice, Nude; Organophosphates; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Quinazolines; Xenograft Model Antitumor Assays | 2011 |
An acetylated polysaccharide-PTFE membrane-covered stent for the delivery of gemcitabine for treatment of gastrointestinal cancer and related stenosis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Constriction, Pathologic; Deoxycytidine; Drug-Eluting Stents; Gastrointestinal Neoplasms; Gemcitabine; Male; Mice; Mice, Inbred BALB C; Polysaccharides; Polytetrafluoroethylene | 2011 |
Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice.
Topics: Adenocarcinoma; Animals; CD11b Antigen; Coculture Techniques; Colonic Neoplasms; Deoxycytidine; Female; Gemcitabine; Interferon gamma Receptor; Interferon Type I; Interferon-gamma; Interferons; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Knockout; Myeloid Cells; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Phosphorylation; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Interferon; Recombinant Proteins; Spleen; STAT1 Transcription Factor; Tumor Escape | 2011 |
Targeting quiescent tumor cells via oxygen and IGF-I supplementation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Culture Techniques; Cell Hypoxia; Cell Proliferation; Cell Survival; Colonic Neoplasms; Deoxycytidine; Drug Synergism; Gemcitabine; HCT116 Cells; HT29 Cells; Humans; Insulin; Insulin-Like Growth Factor I; Mice; Mice, Inbred NOD; Mice, SCID; Oxygen; Paclitaxel; Receptor, IGF Type 1; Xenograft Model Antitumor Assays | 2012 |
Gemcitabine-releasing polymeric films for covered self-expandable metallic stent in treatment of gastrointestinal cancer.
Topics: Alloys; Animals; Antimetabolites, Antineoplastic; Cell Count; Cell Proliferation; Cell Survival; Colonic Neoplasms; Constriction, Pathologic; Cytokines; Deoxycytidine; Drug-Eluting Stents; Gastrointestinal Neoplasms; Gemcitabine; Humans; Membranes, Artificial; Mice; p38 Mitogen-Activated Protein Kinases; Poloxamer; Polymers; Polytetrafluoroethylene; Polyurethanes | 2012 |
ErbB3 expression predicts sensitivity to elisidepsin treatment: in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung, breast and colon cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Deoxycytidine; Depsipeptides; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Gemcitabine; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mitogen-Activated Protein Kinases; Paclitaxel; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4 | 2012 |
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.
Topics: Alleles; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Deoxycytidine; DNA Topoisomerases, Type I; GATA2 Transcription Factor; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mutation; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrazines; ras Proteins; RNA Interference; RNA, Small Interfering; Topoisomerase I Inhibitors; Topotecan; Transcriptional Activation | 2012 |
SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Enzyme Activation; Female; Gemcitabine; Humans; In Situ Nick-End Labeling; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation | 2012 |
Synthesis and biological evaluation of oral prodrugs based on the structure of gemcitabine.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Biological Availability; Carcinoma, Hepatocellular; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Gemcitabine; Humans; Liver Neoplasms; Mice; Neoplasms; Prodrugs | 2012 |
[A case of simultaneous resection of pancreatic tail and transverse hematogenous metastasis].
Topics: Antimetabolites, Antineoplastic; Colonic Neoplasms; Deoxycytidine; Fatal Outcome; Gemcitabine; Humans; Male; Middle Aged; Pancreatectomy; Pancreatic Neoplasms | 2012 |
Comparison of the sulforhodamine B assay and the clonogenic assay for in vitro chemoradiation studies.
Topics: Breast Neoplasms; Colonic Neoplasms; Colony-Forming Units Assay; Colorimetry; Combined Modality Therapy; Deoxycytidine; Fluorescent Dyes; Gemcitabine; Humans; Lung Neoplasms; Radiation-Sensitizing Agents; Radiotherapy; Rhodamines; Sensitivity and Specificity; Tumor Cells, Cultured | 2003 |
High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model.
Topics: Animals; Antineoplastic Agents; Arabinonucleosides; Cell Division; Colonic Neoplasms; Cytosine; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Mice; Mice, Nude; Xenograft Model Antitumor Assays | 2003 |
Combination therapy with Pretarget CC49 radioimmunotherapy and gemcitabine prolongs tumor doubling time in a murine xenograft model of colon cancer more effectively than either monotherapy.
Topics: Animals; Antibodies, Neoplasm; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Cell Cycle; Colonic Neoplasms; Deoxycytidine; Female; Gemcitabine; Humans; Ligands; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Genetic; Neoplasm Transplantation; Radioimmunotherapy; Recombinant Fusion Proteins; Time Factors; Tissue Distribution | 2003 |
Rapid in vitro chemosensitivity analysis of human colon tumor cell lines.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Culture Media; Deoxycytidine; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Humans; Hydrogen-Ion Concentration; Organoplatinum Compounds; Oxaliplatin; Reproducibility of Results; Tetrazolium Salts | 2003 |
Pretreatment with dexamethasone increases antitumor activity of carboplatin and gemcitabine in mice bearing human cancer xenografts: in vivo activity, pharmacokinetics, and clinical implications for cancer chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Carboplatin; Colonic Neoplasms; Deoxycytidine; Dexamethasone; Drug Synergism; Gemcitabine; Glioma; Half-Life; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasms; Transplantation, Heterologous | 2004 |
Chemoembolization of rat liver metastasis with microspheres and gemcitabine followed by evaluation of tumor cell load by chemiluminescence.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chemoembolization, Therapeutic; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Fluorouracil; Gemcitabine; Liver Neoplasms; Male; Microspheres; Neoplasm Transplantation; Organ Size; Rats; Rats, Inbred Strains; Tumor Burden | 2004 |
Effect of LY293111 in combination with gemcitabine in colonic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzoates; Body Weight; Colonic Neoplasms; Deoxycytidine; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Receptors, Leukotriene B4; Transplantation, Heterologous; Tumor Cells, Cultured | 2004 |
Dendritic cell-mediated cross-presentation of antigens derived from colon carcinoma cells exposed to a highly cytotoxic multidrug regimen with gemcitabine, oxaliplatin, 5-fluorouracil, and leucovorin, elicits a powerful human antigen-specific CTL response
Topics: Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Coculture Techniques; Colonic Neoplasms; Cross-Priming; Cytotoxicity, Immunologic; Dendritic Cells; Deoxycytidine; Drug Evaluation, Preclinical; Fluorouracil; Gemcitabine; HLA-A Antigens; HLA-A2 Antigen; HT29 Cells; Humans; Leucovorin; Leukocytes, Mononuclear; Organoplatinum Compounds; Oxaliplatin; T-Lymphocytes, Cytotoxic | 2005 |
Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro.
Topics: Antineoplastic Agents; Cell Proliferation; Cisplatin; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Fibrinolytic Agents; Gemcitabine; HT29 Cells; Humans; Streptokinase; Time Factors | 2006 |
Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autoantigens; Carcinoma, Lewis Lung; Cell Line, Tumor; Collagen Type IV; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Endothelial Cells; Gemcitabine; Genetic Therapy; Genetic Vectors; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Plasmids; Recombinant Proteins; Treatment Outcome | 2005 |
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant.
Topics: Animals; Blotting, Western; Colonic Neoplasms; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression Profiling; Mice; Mice, Inbred BALB C; Nucleoside Deaminases; Oligonucleotide Array Sequence Analysis; Protein Subunits; Ribonucleotide Reductases | 2005 |
Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations.
Topics: Animals; Antimetabolites, Antineoplastic; Chromosome Aberrations; Colonic Neoplasms; Deoxycytidine; DNA Replication; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression; Mice; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis | 2005 |
Combination therapy using gemcitabine and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Drug Administration Schedule; Gemcitabine; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Peritoneal Neoplasms; Radiation-Sensitizing Agents; Radioimmunotherapy | 2006 |
Synergistic anti-tumor effect of recombinant chicken fibroblast growth factor receptor-1-mediated anti-angiogenesis and low-dose gemcitabine in a mouse colon adenocarcinoma model.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cancer Vaccines; Cell Proliferation; Chickens; Colonic Neoplasms; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1; Gemcitabine; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Random Allocation; Recombinant Proteins; Survival Rate | 2007 |
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Cytosine; Deoxycytidine; Dioxolanes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gemcitabine; Humans; Liver Neoplasms; Pancreatic Neoplasms; Phosphoglycerate Kinase; Rhabdomyosarcoma | 2007 |
A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model.
Topics: Adenoviridae; Animals; Antigens, CD; Antigens, Differentiation; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; CTLA-4 Antigen; Cyclophosphamide; Dendritic Cells; Deoxycytidine; Docetaxel; Doxorubicin; Female; Flow Cytometry; Galactosylceramides; Gemcitabine; Genetic Vectors; Glucocorticoid-Induced TNFR-Related Protein; Humans; Immunization; Immunotherapy; Mice; Myeloid Cells; Peptide Fragments; Receptor, ErbB-2; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Taxoids; Transfection; Vaccines, DNA | 2007 |
Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Deoxycytidine; DNA Fragmentation; Gastrointestinal Neoplasms; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Membrane Potentials; Mitochondrial Membranes; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2007 |
Polyaspartylhydrazide copolymer-based supramolecular vesicular aggregates as delivery devices for anticancer drugs.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cells, Cultured; Chromatography, Gel; Chromatography, High Pressure Liquid; Colonic Neoplasms; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Flow Cytometry; Gemcitabine; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Peptides; Polymers; Thyroid Neoplasms; Tumor Cells, Cultured | 2008 |
Occurrence of autoimmunity in a long-term survivor with metastatic colon carcinoma treated with a new chemo-immunotherapy regimen.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; Autoimmunity; Colonic Neoplasms; Deoxycytidine; Female; Flow Cytometry; Fluorouracil; Gemcitabine; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunotherapy; Interleukin-2; Leucovorin; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin | 2008 |
Schedule-dependent antitumor effect of gemcitabine in in vivo model system.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Carcinoma, Squamous Cell; Colonic Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Sarcoma; Soft Tissue Neoplasms | 1995 |
Interaction between cisplatin and gemcitabine in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cisplatin; Colonic Neoplasms; Deoxycytidine; DNA Damage; DNA, Neoplasm; Drug Administration Schedule; Drug Resistance, Neoplasm; Drug Synergism; Drug Tolerance; Female; Fluorometry; Gemcitabine; Head and Neck Neoplasms; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Tumor Cells, Cultured | 1995 |
Synergistic interaction between cisplatin and gemcitabine in ovarian and colon cancer cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Cisplatin; Colonic Neoplasms; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Drug Screening Assays, Antitumor; Drug Synergism; Female; Gemcitabine; Humans; Kinetics; Mice; Nucleoside Deaminases; Ovarian Neoplasms; Time Factors; Tumor Cells, Cultured | 1994 |
[Synergistic cytotoxic effects of chemotherapy in colon tumor cells by simultaneous inhibition of de novo and salvage energy metabolism pathways].
Topics: Allopurinol; Antimetabolites, Antineoplastic; Benzamidines; Cell Line; Cell Survival; Colonic Neoplasms; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Gemcitabine; Humans; Hypoxanthine; Hypoxanthines; Ribavirin; Ribonucleotide Reductases; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Mice; Ovarian Neoplasms; Phosphates; Ribonucleotides; Tumor Cells, Cultured | 1994 |
[Antitumor activity of LY 188011, a new deoxycytidine analog, against human cancers xenografted into nude mice].
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Colonic Neoplasms; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Neoplasm Transplantation; Stomach Neoplasms | 1994 |
Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Gemcitabine; Infusions, Intravenous; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL | 1996 |
Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Cytarabine; Daunorubicin; Deoxycytidine; DNA Mutational Analysis; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gemcitabine; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Lung Neoplasms; Software; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models.
Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Colonic Neoplasms; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Nude; Models, Biological; Molecular Structure; Pancreatic Neoplasms; Transplantation, Heterologous; Treatment Outcome | 1996 |
Induction of in vivo resistance against gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine).
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Colonic Neoplasms; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; Kinetics; Mice; Mice, Inbred BALB C; Thymidine Kinase; Tumor Cells, Cultured | 1998 |
Postconfluent multilayered cell line cultures for selective screening of gemcitabine.
Topics: Antimetabolites, Antineoplastic; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Nucleotides; Ovarian Neoplasms; Tumor Cells, Cultured | 1998 |
Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2',2'-difluoro-2'-deoxycytidine (Gemcitabine).
Topics: Antimetabolites, Antineoplastic; Cell Survival; Cobalt Radioisotopes; Colonic Neoplasms; Deoxycytidine; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electrophoresis, Gel, Pulsed-Field; Gemcitabine; Humans; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1997 |
Cytotoxicity and DNA fragmentation associated with sequential gemcitabine and 5-fluoro-2'-deoxyuridine in HT-29 colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Colonic Neoplasms; Deoxycytidine; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Floxuridine; Gemcitabine; HT29 Cells; Humans; Thymidylate Synthase | 1998 |
Supraadditive effect of 2',2'-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxycytidine; DNA; Gemcitabine; Humans; Leukemia; Organoplatinum Compounds; Oxaliplatin; Tumor Cells, Cultured | 1999 |
Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Death; Cell Division; Colonic Neoplasms; Deoxycytidine; DNA Replication; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; HT29 Cells; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pemetrexed | 1999 |
Comparison of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine with gemcitabine in its antitumor activity.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colonic Neoplasms; Cytarabine; Deoxycytidine; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Interaction between gemcitabine and mitomycin-C in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Mitomycin; Tumor Cells, Cultured | 2000 |
Expression of ERCC1 antisense RNA abrogates gemicitabine-mediated cytotoxic synergism with cisplatin in human colon tumor cells defective in mismatch repair but proficient in nucleotide excision repair.
Topics: Antineoplastic Agents; Base Pair Mismatch; Cell Survival; Cisplatin; Colonic Neoplasms; Deoxycytidine; Deoxycytosine Nucleotides; DNA; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Endonucleases; Gemcitabine; Gene Expression; Humans; Mutation; Proteins; RNA, Antisense; Tumor Cells, Cultured | 2000 |
Tumor biology: use of tiled images in conjunction with measurements of cellular proliferation and death in response to drug treatments.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Colonic Neoplasms; Cyclophosphamide; Deoxycytidine; Female; Gemcitabine; Humans; Image Processing, Computer-Assisted; Lung Neoplasms; Mice; Mice, Nude; Mitomycin; Neoplasms, Experimental; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2000 |
The role of apoptosis in 2',2'-difluoro-2'-deoxycytidine (gemcitabine)-mediated radiosensitization.
Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cobalt Radioisotopes; Colonic Neoplasms; Coumarins; Deoxycytidine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Radiation; Electrophoresis, Gel, Pulsed-Field; Enzyme Activation; Gemcitabine; Head and Neck Neoplasms; Humans; Lung Neoplasms; Oligopeptides; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2001 |
In Vitro schedule-dependent interactions between the multitargeted antifolate LY231514 and gemcitabine in human colon adenocarcinoma cell lines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Apoptosis; Colonic Neoplasms; Deoxycytidine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Resistance, Neoplasm; Drug Therapy, Combination; Flow Cytometry; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; Humans; In Situ Nick-End Labeling; Pemetrexed; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (gemcitabine).
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Carcinoma, Squamous Cell; Cell Division; Cell Line; Colonic Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Female; Gemcitabine; Head and Neck Neoplasms; Humans; Kinetics; Mice; Ovarian Neoplasms | 1991 |