geldanamycin and Urinary-Bladder-Neoplasms

The 90 kD heat shock proteins (Hsp90) are molecular chaperones that are responsible for the folding of select proteins, many of which are directly associated with cancer progression. Consequently, inhibition of the Hsp90 protein folding machinery results in a combinatorial attack on numerous oncogenic pathways. Seventeen small-molecule inhibitors of Hsp90 have entered clinical trials for the treatment of cancer, all of which bind the Hsp90 N-terminus and exhibit

Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Gene Silencing; Heterocyclic Compounds, 4 or More Rings; HSP90 Heat-Shock Proteins; Humans; Models, Molecular; Molecular Conformation; Neoplasms; Protein Folding; Small Molecule Libraries; Structure-Activity Relationship; Substrate Specificity; Urinary Bladder Neoplasms