gedunin and Obesity

gedunin has been researched along with Obesity* in 1 studies

Other Studies

1 other study(ies) available for gedunin and Obesity

Article	Year
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.), 2006, Sep-29, Volume: 313, Issue:5795 To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project. Topics: Alzheimer Disease; Cell Line; Cell Line, Tumor; Databases, Factual; Dexamethasone; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Gene Expression; Gene Expression Profiling; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Limonins; Obesity; Oligonucleotide Array Sequence Analysis; Phenothiazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sirolimus; Software	2006

Article

Year

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Science (New York, N.Y.), 2006, Sep-29, Volume: 313, Issue:5795

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Topics: Alzheimer Disease; Cell Line; Cell Line, Tumor; Databases, Factual; Dexamethasone; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Gene Expression; Gene Expression Profiling; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Limonins; Obesity; Oligonucleotide Array Sequence Analysis; Phenothiazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sirolimus; Software

2006