gdc-0973 has been researched along with Histiocytosis--Langerhans-Cell* in 3 studies
3 other study(ies) available for gdc-0973 and Histiocytosis--Langerhans-Cell
| Article | Year |
|---|---|
Progressive nodular histiocytosis in a 9-year-old boy treated with cobimetinib.
Progressive nodular histiocytosis is a rare variant of non-Langerhans cell histiocytosis that affects the skin and mucous membranes and displays a progressive clinical course and poor response to treatment. We describe a case of severe progressive nodular histiocytosis harboring a KRAS p.G12S mutation in a 9-year-old boy, refractory to chemotherapy, who was successfully treated with the MEK inhibitor cobimetinib. This is the first report of the use of MEK inhibition for this histiocytosis subtype in a pediatric patient. Topics: Azetidines; Child; Histiocytosis; Histiocytosis, Langerhans-Cell; Humans; Male; Piperidines; Skin Diseases | 2022 |
A Novel Histiocytosis With Synovial and Skin Involvement.
Topics: Adult; Azetidines; Female; Histiocytosis, Langerhans-Cell; Humans; Piperidines; Skin; Synovial Membrane | 2021 |
Individualized treatment approaches for Langerhans cell histiocytosis.
Topics: Adrenal Cortex Hormones; Adult; Aged, 80 and over; Azetidines; Bone Diseases; Dermatologic Agents; Female; Histiocytosis, Langerhans-Cell; Humans; Male; Middle Aged; Off-Label Use; Piperidines; Skin Diseases; Thalidomide | 2018 |