gdc-0449 and Spinal-Cord-Neoplasms

We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Punch biopsy from the fungating chest wall lesion showed a BCC with some malignant squamous differentiation (basosquamous). Histopathological examination of the metastatic lesion in T8 at the time of surgical decompression identified features identical to the punch biopsy. The patient was referred to the oncology clinic for adjuvant treatment. In light of his metastatic disease and the large area over his chest wall that could not fully be covered by radiotherapy, he was treated with the novel oral Hedgehog signalling pathway (HHSP) inhibitor vismodegib, which led to marked improvement.

Topics: Aged; Anilides; Animals; Biopsy; Carcinoma, Basal Cell; Decompression, Surgical; Hedgehog Proteins; Humans; Magnetic Resonance Imaging; Male; Pyridines; Signal Transduction; Skin; Skin Neoplasms; Spinal Cord Compression; Spinal Cord Neoplasms; Thoracic Vertebrae; Tomography, X-Ray Computed