gdc-0449 and Renal-Insufficiency

gdc-0449 has been researched along with Renal-Insufficiency* in 2 studies

Other Studies

2 other study(ies) available for gdc-0449 and Renal-Insufficiency

ArticleYear
A case of a patient with severe renal failure on hemodialysis treated with vismodegib for relapsing basal cell carcinoma.
    Tumori, 2018, Volume: 104, Issue:6

    Basal cell carcinoma (BCC) is the most common skin cancer. Treatment options for metastatic or locally advanced BCC inappropriate for surgery or radiotherapy were poor until vismodegib was approved for use in this setting. This drug can be safely used in patients with mild to moderate renal impairment, but limited data are available for its use in case of severe kidney failure. We present the case of a patient with severe renal failure on hemodialysis treated with vismodegib.. An 83-year-old patient with relapsing BCC of both auricles and severe renal failure on hemodialysis was treated with vismodegib for 7 months. The treatment proved to be effective with a striking reduction of the tumor masses. The patient was on therapy with vismodegib for 7 months and no severe adverse event was observed.. Vismodegib could be used in patients with severe renal impairment, but these patients must be attentively followed and strict cooperation among healthcare professionals, such as nephrologists, dermatologists, and medical oncologists, is required.

    Topics: Aged, 80 and over; Anilides; Carcinoma, Basal Cell; Humans; Male; Neoplasm Recurrence, Local; Pyridines; Renal Dialysis; Renal Insufficiency

2018
Effective and Tolerable Treatment of Advanced Basal Cell Carcinoma With Vismodegib Despite Renal Insufficiency.
    JAMA dermatology, 2016, 12-01, Volume: 152, Issue:12

    Topics: Aged; Anilides; Biopsy; Carcinoma, Basal Cell; Dose-Response Relationship, Drug; Humans; Male; Pyridines; Renal Insufficiency; Skin; Skin Neoplasms

2016