gdc-0449 has been researched along with Bone-Diseases--Developmental* in 1 studies
1 other study(ies) available for gdc-0449 and Bone-Diseases--Developmental
| Article | Year |
|---|---|
Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice.
The Hedgehog (Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development. Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the critical period for Hh pathway antagonist-induced frontal bone hypoplasia, we examined patterns of dysmorphology caused by Hh signalling inhibition. Pregnant mice received a single oral administration of Hh signalling inhibitor GDC-0449 at 100 mg•kg Topics: Administration, Oral; Anilides; Animals; Bone Diseases, Developmental; Cell Proliferation; Female; Frontal Bone; Hedgehog Proteins; Limb Deformities, Congenital; Mice; Micrognathism; Osteogenesis; Pregnancy; Pyridines; Signal Transduction | 2019 |